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Stephen H. Safe - Publications

Affiliations: 
1973-1981 University of Guelph, Guelph, Ontario, Canada 
 1981- Texas A & M University, College Station, TX, United States 
Area:
Molecular Biology, Biochemistry
Website:
https://biochemistry.tamu.edu/people/safe-steven/
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Year Citation  Score
2023 Zhang L, Martin G, Mohankumar K, Wright GA, Mariyam F, Safe S. Piperlongumine is a ligand for the orphan nuclear receptor 4A1 (NR4A1). Frontiers in Pharmacology. 14: 1223153. PMID 37808182 DOI: 10.3389/fphar.2023.1223153  0.381
2023 Zhang L, Mohankumar K, Martin G, Mariyam F, Park Y, Han SJ, Safe S. Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice. Endocrinology. PMID 37652054 DOI: 10.1210/endocr/bqad133  0.308
2022 Safe S, Zhang L. The Role of the Aryl Hydrocarbon Receptor (AhR) and Its Ligands in Breast Cancer. Cancers. 14. PMID 36428667 DOI: 10.3390/cancers14225574  0.348
2022 Schoeller A, Karki K, Jayaraman A, Chapkin RS, Safe S. Short chain fatty acids exhibit selective estrogen receptor downregulator (SERD) activity in breast cancer. American Journal of Cancer Research. 12: 3422-3436. PMID 35968335  0.324
2022 Park H, Jin UH, Martin G, Chapkin RS, Davidson LA, Lee K, Jayaraman A, Safe S. Structure-activity relationships among mono- and dihydroxy flavones as aryl hydrocarbon receptor (AhR) agonists or antagonists in CACO2 cells. Chemico-Biological Interactions. 365: 110067. PMID 35917944 DOI: 10.1016/j.cbi.2022.110067  0.328
2022 Zhang L, Martin G, Mohankumar K, Hampton JT, Liu WR, Safe S. . Molecular Pharmacology. PMID 35680166 DOI: 10.1124/molpharm.121.000481  0.33
2022 Zarei M, Shrestha R, Johnson S, Yu Z, Karki K, Vaziri-Gohar A, Epps J, Du H, Suva L, Zarei M, Safe S. Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma. Cancer Research Communications. 1: 65-78. PMID 35582016 DOI: 10.1158/2767-9764.crc-21-0073  0.336
2022 Lee HS, Kim DH, Lee IS, Park JH, Martin G, Safe S, Kim KJ, Kim JH, Jang BI, Lee SO. Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo. International Journal of Molecular Sciences. 23. PMID 35563670 DOI: 10.3390/ijms23095280  0.4
2021 Safe S, Shrestha R, Mohankumar K, Howard M, Hedrick E, Abdelrahim M. Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer. World Journal of Gastroenterology. 27: 6387-6398. PMID 34720529 DOI: 10.3748/wjg.v27.i38.6387  0.335
2021 Mohankumar K, Shrestha R, Safe S. Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells. Molecular Carcinogenesis. PMID 34699643 DOI: 10.1002/mc.23362  0.4
2021 Karki K, Mohankumar K, Schoeller A, Martin G, Shrestha R, Safe S. NR4A1 Ligands as Potent Inhibitors of Breast Cancer Cell and Tumor Growth. Cancers. 13. PMID 34072371 DOI: 10.3390/cancers13112682  0.36
2021 Lee HS, Kim SH, Kim BM, Safe S, Lee SO. Broussochalcone A Is a Novel Inhibitor of the Orphan Nuclear Receptor NR4A1 and Induces Apoptosis in Pancreatic Cancer Cells. Molecules (Basel, Switzerland). 26. PMID 33923503 DOI: 10.3390/molecules26082316  0.4
2021 Chidambara Murthy KN, Jayaprakasha GK, Safe S, Patil BS. Citrus limonoids induce apoptosis and inhibit the proliferation of pancreatic cancer cells. Food & Function. PMID 33427831 DOI: 10.1039/d0fo02740e  0.335
2020 Park H, Jin UH, Karki K, Allred C, Davidson LA, Chapkin RS, Orr AA, Nowshad F, Jayaraman A, Tamamis P, Safe S. Hydroxylated Chalcones as Aryl Hydrocarbon Receptor Agonists: Structure-Activity Effects. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 33263770 DOI: 10.1093/toxsci/kfaa179  0.357
2020 Safe S, Karki K. The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer. Molecular Cancer Research : McR. PMID 33106376 DOI: 10.1158/1541-7786.MCR-20-0707  0.343
2020 Safe S, Jin UH, Park H, Chapkin RS, Jayaraman A. Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs). International Journal of Molecular Sciences. 21. PMID 32932962 DOI: 10.3390/Ijms21186654  0.372
2020 Shrestha R, Mohankumar K, Safe S. Bis-indole derived nuclear receptor 4A1 (NR4A1) antagonists inhibit TGFβ-induced invasion of embryonal rhabdomyosarcoma cells. American Journal of Cancer Research. 10: 2495-2509. PMID 32905449  0.345
2020 Jin UH, Michelhaugh SK, Polin LA, Shrestha R, Mittal S, Safe S. Omeprazole Inhibits Glioblastoma Cell Invasion and Tumor Growth. Cancers. 12. PMID 32731514 DOI: 10.3390/Cancers12082097  0.411
2020 Safe S, Jayaraman A, Chapkin RS. Ah receptor ligands and their impacts on gut resilience: structure-activity effects. Critical Reviews in Toxicology. 1-11. PMID 32597352 DOI: 10.1080/10408444.2020.1773759  0.361
2020 Mohankumar K, Li X, Sung N, Cho YJ, Han SJ, Safe S. BIS-INDOLE DERIVED NUCLEAR RECEPTOR 4A1 (NR4A1, Nur77) LIGANDS AS INHIBITORS OF ENDOMETRIOSIS. Endocrinology. PMID 32099996 DOI: 10.1210/Endocr/Bqaa027  0.429
2020 Nottingham E, Sekar V, Mondal A, Safe S, Rishi A, Singh M. The role of Self Nano Emulsifying drug delivery systems of CDODA-Me in sensitizing Erlotinib resistant Nonsmall cell lung cancer. Journal of Pharmaceutical Sciences. PMID 31954111 DOI: 10.1016/J.Xphs.2020.01.010  0.35
2020 Karki K, Wright GA, Mohankumar K, Jin UH, Zhang XH, Safe S. A Bis-Indole-Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Anti-Tumor Immunity. Cancer Research. PMID 31911554 DOI: 10.1158/0008-5472.Can-19-2314  0.339
2020 Garcia-Villatoro EL, DeLuca JA, Callaway ES, Allred KF, Davidson LA, Hensel ME, Menon R, Ivanov I, Safe S, Jayaraman A, Chapkin RS, Allred CD. Effects Of High Fat Diet And Intestinal Aryl Hydrocarbon Receptor Deletion On Colon Carcinogenesis. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 31905023 DOI: 10.1152/Ajpgi.00268.2019  0.319
2019 Karki K, Li X, Jin UH, Mohankumar K, Zarei M, Michelhaugh SK, Mittal S, Tjalkens R, Safe S. Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas. Journal of Neuro-Oncology. PMID 31754919 DOI: 10.1007/S11060-019-03349-Y  0.326
2019 Park H, Jin UH, Orr AA, Echegaray SP, Davidson LA, Allred CD, Chapkin R, Jayaraman A, Lee K, Tamamis P, Safe SH. Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships. Chemical Research in Toxicology. PMID 31621310 DOI: 10.1021/Acs.Chemrestox.9B00352  0.449
2019 Safe S, Hedrick E, Mohankumar K, Lacey A. INHIBITION OF NR4A1 PROMOTES ROS ACCUMULATION AND IL-24 - DEPENDENT GROWTH ARREST IN RHABDOMYOSARCOMA. Molecular Cancer Research : McR. PMID 31462501 DOI: 10.1158/1541-7786.Mcr-19-0408  0.385
2019 Jin UH, Karki K, Cheng Y, Michelhaugh SK, Mittal S, Safe S. The aryl hydrocarbon receptor is a tumor suppressor-like gene in glioblastoma. The Journal of Biological Chemistry. PMID 31171720 DOI: 10.1074/Jbc.Ra119.008882  0.41
2019 Hedrick E, Li X, Cheng Y, Lacey A, Mohankumar K, Zarei M, Safe S. Potent inhibition of breast cancer by bis-indole-derived nuclear receptor 4A1 (NR4A1) antagonists. Breast Cancer Research and Treatment. PMID 31119568 DOI: 10.1007/S10549-019-05279-9  0.456
2019 Li X, Tjalkens RB, Shrestha R, Safe S. Structure-dependent Activation of Gene Expression by Bis-indole and Quinoline-derived Activators of Nuclear Receptor 4A2. Chemical Biology & Drug Design. PMID 31102570 DOI: 10.1111/Cbdd.13564  0.435
2019 Mohankumar K, Li X, Sridharan S, Karki K, Safe S. Nuclear receptor 4A1 (NR4A1) antagonists induce ROS-dependent inhibition of mTOR signaling in endometrial cancer. Gynecologic Oncology. PMID 31053403 DOI: 10.1016/J.Ygyno.2019.04.678  0.437
2019 Yoon K, Chen CC, Orr AA, Barreto PN, Tamamis P, Safe S. Activation of COUP-TFI by a Novel Diindolylmethane Derivative. Cells. 8. PMID 30866413 DOI: 10.3390/Cells8030220  0.674
2019 Kasiappan R, Jutooru I, Mohankumar K, Karki K, Lacey A, Safe S. Reactive Oxygen Species (ROS)-inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors. Molecular Cancer Research : McR. PMID 30610105 DOI: 10.1158/1541-7786.Mcr-18-1071  0.772
2019 Jin U, Karki K, Safe S. Abstract 154: Inhibition of pancreatic cancer Panc-1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-154  0.459
2019 Harishchandra S, Li X, Safe S, Zarei M. Abstract 1714: Nuclear receptor Nurr1 facilitates pancreatic ductal adenocarcinoma cell survival under metabolic stress Cancer Research. 79: 1714-1714. DOI: 10.1158/1538-7445.Am2019-1714  0.417
2018 Safe S, Han H, Goldsby J, Mohankumar K, Chapkin RS. Aryl Hydrocarbon Receptor (AhR) Ligands as Selective AhR Modulators: Genomic Studies. Current Opinion in Toxicology. 11: 10-20. PMID 31453421 DOI: 10.1016/J.Cotox.2018.11.005  0.325
2018 Karki K, Harishchandra S, Safe SH. Bortezomib Targets Sp Transcription Factors in Cancer Cells. Molecular Pharmacology. PMID 30115673 DOI: 10.1124/mol.118.112797  0.355
2018 Hedrick E, Mohankumar K, Safe S. TGFbeta-induced Lung Cancer Cell Migration is NR4A1-dependent. Molecular Cancer Research : McR. PMID 30072581 DOI: 10.1158/1541-7786.Mcr-18-0366  0.378
2018 Afzali MF, Popichak KA, Burton LH, Klochak AL, Wilson WJ, Safe S, Tjalkens RB, Legare ME. A novel diindolylmethane analog, 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor necrosis factor-induced inflammatory response in primary murine synovial fibroblasts through a Nurr1-dependent mechanism. Molecular Immunology. 101: 46-54. PMID 29870816 DOI: 10.1016/J.Molimm.2018.05.024  0.362
2018 Jin UH, Karki K, Kim SB, Safe S. Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK. Biochemical and Biophysical Research Communications. PMID 29758193 DOI: 10.1016/J.Bbrc.2018.05.061  0.45
2018 Mohankumar K, Lee J, Wu CS, Sun Y, Safe S. Bis-Indole-Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells. Endocrinology. 159: 1950-1963. PMID 29635345 DOI: 10.1210/En.2017-03049  0.366
2018 Hammond SL, Popichak KA, Li X, Hunt LG, Richman EH, Damale P, Chong E, Backos DS, Safe S, Tjalkens RB. The Nurr1 ligand,1,1-bis(3'-indolyl)-1-(p-chlorophenyl)methane, modulates glial reactivity and is neuroprotective in MPTP-induced parkinsonism. The Journal of Pharmacology and Experimental Therapeutics. PMID 29626009 DOI: 10.1124/Jpet.117.246389  0.352
2018 Draz H, Goldberg AA, Tomlinson Guns ES, Fazli L, Safe S, Sanderson JT. Autophagy inhibition improves the chemotherapeutic efficacy of cruciferous vegetable-derived diindolymethane in a murine prostate cancer xenograft model. Investigational New Drugs. PMID 29607466 DOI: 10.1007/S10637-018-0595-8  0.368
2018 Jin UH, Park H, Li X, Davidson LA, Allred C, Patil B, Jayaprakasha G, Orr AA, Mao L, Chapkin RS, Jayaraman A, Tamamis P, Safe S. Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavones. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29584932 DOI: 10.1093/Toxsci/Kfy075  0.412
2018 Safe S, Abbruzzese JL, Abdelrahim M, Hedrick E. Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development. Cancer Prevention Research (Philadelphia, Pa.). PMID 29545399 DOI: 10.1158/1940-6207.Capr-17-0407  0.476
2018 Choudhary M, Safe S, Malek G. Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor. Biochimica Et Biophysica Acta. PMID 29481912 DOI: 10.1016/J.Bbadis.2018.02.015  0.363
2018 Cheng Y, Imanirad P, Jutooru I, Hedrick E, Jin UH, Rodrigues Hoffman A, Leal de Araujo J, Morpurgo B, Golovko A, Safe S. Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer. Plos One. 13: e0192264. PMID 29389953 DOI: 10.1371/Journal.Pone.0192264  0.764
2017 Safe S, Naira V, Karki K. Metformin-induced anticancer activities: recent insights. Biological Chemistry. PMID 29272251 DOI: 10.1515/Hsz-2017-0271  0.46
2017 Li Y, Wang F, Lu L, Zhu F, Huang S, Nomie K, Zhang L, Yang DT, Huang W, Kahl BS, Safe S, Wang M, Rui L. NR4A1 inhibition synergizes with ibrutinib in killing mantle cell lymphoma cells. Blood Cancer Journal. 7: 632. PMID 29167454 DOI: 10.1038/S41408-017-0005-Z  0.343
2017 Safe S. Carbidopa: a selective Ah receptor modulator (SAhRM). The Biochemical Journal. 474: 3763-3765. PMID 29109131 DOI: 10.1042/Bcj20170728  0.433
2017 Jin UH, Cheng Y, Park H, Davidson LA, Callaway ES, Chapkin RS, Jayaraman A, Asante A, Allred C, Weaver EA, Safe S. Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells. Scientific Reports. 7: 10163. PMID 28860561 DOI: 10.1038/S41598-017-10824-X  0.411
2017 Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S. Correction for Hedrick et al., "NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration". Molecular and Cellular Biology. 37. PMID 28847971 DOI: 10.1128/Mcb.00197-17  0.346
2017 Lee HS, Safe S, Lee SO. Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells. Toxicology and Applied Pharmacology. PMID 28754437 DOI: 10.1016/J.Taap.2017.07.017  0.496
2017 Kolluri SK, Jin UH, Safe S. Erratum to: Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target. Archives of Toxicology. PMID 28695231 DOI: 10.1007/S00204-017-2026-6  0.34
2017 Hedrick E, Safe S. TGFβ/NR4A1 Inducible Breast Cancer Cell Migration and Epithelial to Mesenchymal Transition is p38α (MAPK14) Dependent. Molecular and Cellular Biology. PMID 28674186 DOI: 10.1128/Mcb.00306-17  0.411
2017 Karki K, Hedrick E, Kasiappan R, Jin UH, Safe S. Piperlongumine Induces Reactive Oxygen Species (ROS)-dependent Downregulation of Specificity Protein Transcription Factors. Cancer Prevention Research (Philadelphia, Pa.). PMID 28673967 DOI: 10.1158/1940-6207.Capr-17-0053  0.468
2017 Kolluri SK, Jin UH, Safe S. Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target. Archives of Toxicology. PMID 28508231 DOI: 10.1007/S00204-017-1981-2  0.428
2017 Safe S, Cheng Y, Jin UH. The Aryl Hydrocarbon Receptor (AhR) as a Drug Target for Cancer Chemotherapy. Current Opinion in Toxicology. 2: 24-29. PMID 28459113 DOI: 10.1016/J.Cotox.2017.01.012  0.434
2017 Hedrick E, Lee SO, Safe S. The Nuclear Orphan Receptor NR4A1 Regulates β1-Integrin Expression in Pancreatic and Colon Cancer Cells and Can Be Targeted by NR4A1 Antagonists. Molecular Carcinogenesis. PMID 28418095 DOI: 10.1002/Mc.22662  0.419
2017 Taoka R, Jinesh GG, Xue W, Safe S, Kamat AM. CF3DODA-Me induces apoptosis, degrades Sp1, and blocks the transformation phase of the blebbishield emergency program. Apoptosis : An International Journal On Programmed Cell Death. PMID 28283889 DOI: 10.1007/S10495-017-1359-1  0.385
2017 Jin U, Cheng Y, Zhou B, Safe S. The Antineoplastic Activity of Bardoxolone Methyl and a Related Triterpenoid in Leukemia Cells Is Due to Reactive Oxygen Species-Dependent Suppression of cMyc. Molecular Pharmacology. PMID 28275049 DOI: 10.1124/Mol.116.106245  0.433
2017 Draz H, Goldberg A, Sanderson T, Safe S. Abstract 3298: Diindolylmethane and its halogenated analogues induce autophagy in human prostate cancer cells via induction of the astrocyte-elevated gene-1 (AEG-1) Cancer Research. 77: 3298-3298. DOI: 10.1158/1538-7445.Am2017-3298  0.405
2016 Kasiappan R, Jutooru I, Karki K, Hedrick E, Safe SH. Benzylisothiocyanate (BITC) Induces ROS-dependent Repression of STAT3 by Downregulation of Specificity Proteins in Pancreatic Cancer. The Journal of Biological Chemistry. PMID 27875298 DOI: 10.1074/Jbc.M116.746339  0.771
2016 Lacey A, Rodrigues Hoffman A, Safe S. PAX3-FOXO1A expression in rhabdomyosarcoma is driven by the targetable nuclear receptor NR4A1. Cancer Research. PMID 27864345 DOI: 10.1158/0008-5472.Can-16-1546  0.421
2016 Cheng Y, Jin UH, Davidson LA, Chapkin RS, Jayaraman A, Tamamis P, Orr A, Allred C, Denison MS, Soshilov A, Weaver E, Safe S. Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27837168 DOI: 10.1093/Toxsci/Kfw230  0.433
2016 Bridi MS, Hawk JD, Chatterjee S, Safe S, Abel T. Pharmacological Activators of the NR4A Nuclear Receptors Enhance LTP in a CREB/CBP-Dependent Fashion. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27834392 DOI: 10.1038/Npp.2016.253  0.309
2016 Hedrick E, Li X, Safe S. Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors. Molecular Cancer Therapeutics. PMID 27811009 DOI: 10.1158/1535-7163.Mct-16-0451  0.418
2016 Safe S, Kasiappan R. Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets. Phytotherapy Research : Ptr. PMID 27384261 DOI: 10.1002/Ptr.5669  0.473
2016 Moore RW, Fritz WA, Schneider AJ, Lin TM, Branam AM, Safe S, Peterson RE. 2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice. Toxicology and Applied Pharmacology. PMID 27151233 DOI: 10.1016/J.Taap.2016.04.018  0.317
2016 Lacey A, Hedrick E, Li X, Patel K, Doddapaneni R, Singh M, Safe S. Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS). Oncotarget. PMID 27144436 DOI: 10.18632/Oncotarget.9112  0.482
2016 Takeuchi H, Taoka R, Mmeje CO, Jinesh GG, Safe S, Kamat AM. CDODA-Me decreases specificity protein transcription factors and induces apoptosis in bladder cancer cells through induction of reactive oxygen species. Urologic Oncology. PMID 27038699 DOI: 10.1016/J.Urolonc.2016.02.025  0.451
2016 Hedrick E, Cheng Y, Jin UH, Kim K, Safe S. Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells. Oncotarget. PMID 26967243 DOI: 10.18632/Oncotarget.7925  0.743
2016 Delgado E, Boisen MM, Laskey R, Chen R, Song C, Sallit J, Yochum ZA, Andersen CL, Sikora MJ, Wagner J, Safe S, Elishaev E, Lee A, Edwards RP, Haluska P, et al. High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecologic Oncology. PMID 26946093 DOI: 10.1016/J.Ygyno.2016.02.030  0.388
2016 Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S. NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration. Molecular and Cellular Biology. PMID 26929200 DOI: 10.1128/Mcb.00912-15  0.356
2016 Takeuchi H, Taoka R, Jinesh GG, Mmeje CO, Safe S, Aoyagi T, Tachibana M, Kamat AM. Mp45-02 Cdoda-Me Decreases Specificity Protein Transcription Factors And Induces Apoptosis In Bladder Cancer Cells Through Induction Of Reactive Oxygen Species The Journal of Urology. 195. DOI: 10.1016/J.Juro.2016.02.279  0.396
2015 Li X, Pathi SS, Safe S. Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors. Bmc Cancer. 15: 974. PMID 26673922 DOI: 10.1186/S12885-015-1956-8  0.787
2015 Safe S. MicroRNA-Specificity Protein (Sp) Transcription Factor Interactions and Significance in Carcinogenesis. Current Pharmacology Reports. 1: 73-78. PMID 26457240 DOI: 10.1007/S40495-014-0012-8  0.347
2015 Hammond SL, Safe S, Tjalkens RB. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neuroscience Letters. 607: 83-9. PMID 26383113 DOI: 10.1016/J.Neulet.2015.09.015  0.332
2015 Gandhy SU, Imanirad P, Jin UH, Nair V, Hedrick E, Cheng Y, Corton JC, Kim K, Safe S. Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC. Oncotarget. PMID 26317792 DOI: 10.18632/Oncotarget.4560  0.738
2015 Boakye CH, Shah PP, Doddapaneni R, Patel AR, Safe S, Singh M. Enhanced Percutaneous Delivery of 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) Methane for Skin Cancer Chemoprevention. Journal of Biomedical Nanotechnology. 11: 1269-81. PMID 26307849 DOI: 10.1166/Jbn.2015.2064  0.302
2015 Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Breast Cancer Chemotherapy. Endocrine-Related Cancer. PMID 26229035 DOI: 10.1530/Erc-15-0063  0.516
2015 Riddell N, Jin UH, Safe S, Cheng Y, Chittim B, Konstantinov A, Parette R, Pena-Abaurrea M, Reiner EJ, Poirier D, Stefanac T, McAlees AJ, McCrindle R. Characterization and Biological Potency of Mono- to Tetra-Halogenated Carbazoles. Environmental Science & Technology. 49: 10658-66. PMID 26226543 DOI: 10.1021/Acs.Est.5B02751  0.408
2015 Hedrick E, Crose L, Linardic CM, Safe S. Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors. Molecular Cancer Therapeutics. 14: 2143-53. PMID 26162688 DOI: 10.1158/1535-7163.Mct-15-0148  0.393
2015 Das Gupta S, Sae-Tan S, Wahler J, So JY, Bak MJ, Cheng LC, Lee MJ, Lin Y, Shih WJ, Shull JD, Safe S, Yang CS, Suh N. Dietary γ-Tocopherol Rich Mixture Inhibits Estrogen-Induced Mammary Tumorigenesis by Modulating Estrogen Metabolism, Antioxidant Response and PPARγ. Cancer Prevention Research (Philadelphia, Pa.). PMID 26130252 DOI: 10.1158/1940-6207.Capr-15-0154  0.417
2015 Hedrick E, Lee SO, Kim G, Abdelrahim M, Jin UH, Safe S, Abudayyeh A. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. Plos One. 10: e0128308. PMID 26035713 DOI: 10.1371/Journal.Pone.0128308  0.473
2015 Fan YY, Davidson LA, Callaway ES, Wright GA, Safe S, Chapkin RS. A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 309: G1-9. PMID 25977509 DOI: 10.1152/Ajpgi.00052.2015  0.356
2015 Safe S, Jin UH, Morpurgo B, Abudayyeh A, Singh M, Tjalkens RB. Nuclear receptor 4A (NR4A) family - orphans no more. The Journal of Steroid Biochemistry and Molecular Biology. PMID 25917081 DOI: 10.1016/J.Jsbmb.2015.04.016  0.366
2015 Cheng Y, Jutooru I, Chadalapaka G, Corton JC, Safe S. The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget. 6: 10840-52. PMID 25912306 DOI: 10.18632/Oncotarget.3450  0.76
2015 Cheng Y, Jin UH, Allred CD, Jayraman A, Chapkin RS, Safe S. Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 25873348 DOI: 10.1124/Dmd.115.063677  0.436
2015 De Miranda BR, Popichak KA, Hammond SL, Jorgensen BA, Phillips AT, Safe S, Tjalkens RB. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Molecular Pharmacology. 87: 1021-34. PMID 25858541 DOI: 10.1124/Mol.114.095398  0.419
2015 Jin UH, Kim SB, Safe S. Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway. Chemical Research in Toxicology. 28: 907-18. PMID 25826687 DOI: 10.1021/Tx5005198  0.469
2015 Safe S. Targeting apoptosis pathways in cancer--letter. Cancer Prevention Research (Philadelphia, Pa.). 8: 338. PMID 25627800 DOI: 10.1158/1940-6207.Capr-14-0405  0.385
2015 De Miranda BR, Popichak KA, Hammond SL, Miller JA, Safe S, Tjalkens RB. Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease. Toxicological Sciences : An Official Journal of the Society of Toxicology. 143: 360-73. PMID 25406165 DOI: 10.1093/Toxsci/Kfu236  0.365
2015 Safe S, Lee SO, Meng C, Zhou B. Nr4a orphan receptors as drug targets Targeted Therapy of Acute Myeloid Leukemi. 509-528. DOI: 10.1007/978-1-4939-1393-0_26  0.331
2014 Yang WS, Chadalapaka G, Cho SG, Lee SO, Jin UH, Jutooru I, Choi K, Leung YK, Ho SM, Safe S, Kim K. The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis. Neoplasia (New York, N.Y.). 16: 1059-69. PMID 25499219 DOI: 10.1016/J.Neo.2014.09.011  0.824
2014 Nair V, Sreevalsan S, Basha R, Abdelrahim M, Abudayyeh A, Rodrigues Hoffman A, Safe S. Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors. The Journal of Biological Chemistry. 289: 27692-701. PMID 25143389 DOI: 10.1074/jbc.M114.592576  0.338
2014 Lee SO, Li X, Hedrick E, Jin UH, Tjalkens RB, Backos DS, Li L, Zhang Y, Wu Q, Safe S. Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells. Molecular Endocrinology (Baltimore, Md.). 28: 1729-39. PMID 25099012 DOI: 10.1210/Me.2014-1102  0.55
2014 Jin UH, Lee SO, Pfent C, Safe S. The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis. Bmc Cancer. 14: 498. PMID 25011475 DOI: 10.1186/1471-2407-14-498  0.407
2014 Safe S, Imanirad P, Sreevalsan S, Nair V, Jutooru I. Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target. Expert Opinion On Therapeutic Targets. 18: 759-69. PMID 24793594 DOI: 10.1517/14728222.2014.914173  0.742
2014 Zhang Z, Kim K, Li X, Moreno M, Sharp T, Goodheart MJ, Safe S, Dupuy AJ, Amendt BA. MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression. Molecular Cancer Therapeutics. 13: 1942-51. PMID 24785257 DOI: 10.1158/1535-7163.Mct-13-1000  0.743
2014 Jutooru I, Guthrie AS, Chadalapaka G, Pathi S, Kim K, Burghardt R, Jin UH, Safe S. Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents. Molecular and Cellular Biology. 34: 2382-95. PMID 24732804 DOI: 10.1128/Mcb.01602-13  0.798
2014 Jin UH, Lee SO, Sridharan G, Lee K, Davidson LA, Jayaraman A, Chapkin RS, Alaniz R, Safe S. Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities. Molecular Pharmacology. 85: 777-88. PMID 24563545 DOI: 10.1124/Mol.113.091165  0.442
2014 Lee SO, Jin UH, Kang JH, Kim SB, Guthrie AS, Sreevalsan S, Lee JS, Safe S. The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Molecular Cancer Research : McR. 12: 527-38. PMID 24515801 DOI: 10.1158/1541-7786.Mcr-13-0567  0.445
2014 Safe S, Jin UH, Hedrick E, Reeder A, Lee SO. Minireview: role of orphan nuclear receptors in cancer and potential as drug targets. Molecular Endocrinology (Baltimore, Md.). 28: 157-72. PMID 24295738 DOI: 10.1210/Me.2013-1291  0.458
2014 Goldberg AA, Titorenko VI, Beach A, Abdelbaqi K, Safe S, Sanderson JT. Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells. Investigational New Drugs. 32: 25-36. PMID 23709189 DOI: 10.1007/S10637-013-9979-Y  0.397
2014 Pathi S, Li X, Safe S. Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors. Molecular Carcinogenesis. 53: E53-61. PMID 23670891 DOI: 10.1002/Mc.22010  0.817
2014 Abdelrahim M, Bilen MA, Safe S, Abudayyeh A. Abstract 4532: New tolfenamic acid's derivatives inhibit cancer cells growth and tumor progression: Pre-clinical studies update Cancer Research. 74: 4532-4532. DOI: 10.1158/1538-7445.Am2014-4532  0.483
2014 Doddapaneni R, Boakye C, Shah P, Patel AR, Godugu C, Safe S, Katiyar S, Sachdeva M. Abstract 3139: Nurr1, a novel target of 1,1-bis(3’-indolyl)-1-(p-chlorophenyl) methane for inhibition of the initiation and progression of skin cancer tumorigenesis Cancer Research. 74: 3139-3139. DOI: 10.1158/1538-7445.Am2014-3139  0.334
2013 Sreevalsan S, Safe S. REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER. Current Colorectal Cancer Reports. 9: 350-357. PMID 25584043 DOI: 10.1007/S11888-013-0190-5  0.422
2013 Sreevalsan S, Safe S. The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells. Molecular Cancer Therapeutics. 12: 2483-93. PMID 24030632 DOI: 10.1158/1535-7163.Mct-13-0486  0.449
2013 Boakye CH, Doddapaneni R, Shah PP, Patel AR, Godugu C, Safe S, Katiyar SK, Singh M. Chemoprevention of skin cancer with 1,1-Bis (3'-indolyl)-1-(aromatic) methane analog through induction of the orphan nuclear receptor, NR4A2 (Nurr1). Plos One. 8: e69519. PMID 23950896 DOI: 10.1371/Journal.Pone.0069519  0.348
2013 Andey T, Patel A, Jackson T, Safe S, Singh M. 1,1-Bis (3'-indolyl)-1-(p-substitutedphenyl)methane compounds inhibit lung cancer cell and tumor growth in a metastasis model. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 50: 227-41. PMID 23892137 DOI: 10.1016/J.Ejps.2013.07.007  0.354
2013 Nair V, Pathi S, Jutooru I, Sreevalsan S, Basha R, Abdelrahim M, Samudio I, Safe S. Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors. Carcinogenesis. 34: 2870-9. PMID 23803693 DOI: 10.1093/Carcin/Bgt231  0.831
2013 Safe S, Lee SO, Jin UH. Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target. Toxicological Sciences : An Official Journal of the Society of Toxicology. 135: 1-16. PMID 23771949 DOI: 10.1093/Toxsci/Kft128  0.417
2013 Bousquet M, Zhuang G, Meng C, Ying W, Cheruku PS, Shie AT, Wang S, Ge G, Wong P, Wang G, Safe S, Zhou B. miR-150 blocks MLL-AF9-associated leukemia through oncogene repression. Molecular Cancer Research : McR. 11: 912-22. PMID 23604034 DOI: 10.1158/1541-7786.Mcr-13-0002-T  0.31
2013 Del Follo-Martinez A, Banerjee N, Li X, Safe S, Mertens-Talcott S. Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a. Nutrition and Cancer. 65: 494-504. PMID 23530649 DOI: 10.1080/01635581.2012.725194  0.444
2013 Noratto GD, Jutooru I, Safe S, Angel-Morales G, Mertens-Talcott SU. The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis. Molecular Nutrition & Food Research. 57: 1638-48. PMID 23471840 DOI: 10.1002/Mnfr.201200609  0.772
2013 Shin JA, Jung JY, Ryu MH, Safe S, Cho SD. Mithramycin A inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of Bax and oligomerization. Molecular Pharmacology. 83: 33-41. PMID 23019217 DOI: 10.1124/Mol.112.081364  0.414
2013 Chadalapaka G, Jutooru I, Sreevalsan S, Pathi S, Kim K, Chen C, Crose L, Linardic C, Safe S. Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors. International Journal of Cancer. 132: 795-806. PMID 22815231 DOI: 10.1002/Ijc.27730  0.821
2013 Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, Kim S, Safe S. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 32: 1616-25. PMID 22614017 DOI: 10.1038/Onc.2012.193  0.828
2013 Mertens-Talcott SU, Noratto GD, Li X, Angel-Morales G, Bertoldi MC, Safe S. Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10. Molecular Carcinogenesis. 52: 591-602. PMID 22407812 DOI: 10.1002/Mc.21893  0.478
2013 Cheruku PS, Bousquet M, Zhang G, Ge G, Ying W, Meng C, Shie A, Wang S, Wong P, Wang G, Safe S, Zhou B. MiR-150 Inhibits MLL-AF9 Associated Leukemia By Suppressing Leukemic Stem Cells Blood. 122: 3764-3764. DOI: 10.1182/Blood.V122.21.3764.3764  0.315
2013 Safe S, Jin U, Lee S. The orphan receptor NR4A1 (TR3/Nur77) as a drug target for cancer chemotherapy Toxicology Letters. 221. DOI: 10.1016/J.Toxlet.2013.06.104  0.336
2012 Gandhy SU, Kim K, Larsen L, Rosengren RJ, Safe S. Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs. Bmc Cancer. 12: 564. PMID 23194063 DOI: 10.1186/1471-2407-12-564  0.758
2012 Pathi S, Jutooru I, Chadalapaka G, Nair V, Lee SO, Safe S. Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors. Plos One. 7: e48208. PMID 23110215 DOI: 10.1371/Journal.Pone.0048208  0.842
2012 Banerjee N, Talcott S, Safe S, Mertens-Talcott SU. Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation. Breast Cancer Research and Treatment. 136: 21-34. PMID 22941571 DOI: 10.1007/S10549-012-2224-0  0.447
2012 Jin UH, Lee SO, Safe S. Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cells. The Journal of Pharmacology and Experimental Therapeutics. 343: 333-41. PMID 22879383 DOI: 10.1124/jpet.112.195339  0.397
2012 Kim K, Chadalapaka G, Pathi SS, Jin UH, Lee JS, Park YY, Cho SG, Chintharlapalli S, Safe S. Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters. Molecular Cancer Therapeutics. 11: 1852-62. PMID 22752225 DOI: 10.1158/1535-7163.Mct-12-0181  0.815
2012 Safe SH, Prather PL, Brents LK, Chadalapaka G, Jutooru I. Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs. Anti-Cancer Agents in Medicinal Chemistry. 12: 1211-20. PMID 22583404 DOI: 10.2174/187152012803833099  0.762
2012 Liu X, Jutooru I, Lei P, Kim K, Lee SO, Brents LK, Prather PL, Safe S. Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer. Molecular Cancer Therapeutics. 11: 1421-31. PMID 22553354 DOI: 10.1158/1535-7163.Mct-12-0026  0.827
2012 Wilson H, Chadalapaka G, Jutooru I, Sheppard S, Pfent C, Safe S. Effect of Tolfenamic Acid on Canine Cancer Cell Proliferation, Specificity Protein (Sp) Transcription Factors, and Sp-Regulated Proteins in Canine Osteosarcoma, Mammary Carcinoma, and Melanoma Cells Journal of Veterinary Internal Medicine. 26: 977-986. PMID 22536857 DOI: 10.1111/J.1939-1676.2012.00931.X  0.769
2012 Schulz VJ, Smit JJ, Huijgen V, Bol-Schoenmakers M, van Roest M, Kruijssen LJ, Fiechter D, Hassing I, Bleumink R, Safe S, van Duursen MB, van den Berg M, Pieters RH. Non-dioxin-like AhR ligands in a mouse peanut allergy model. Toxicological Sciences : An Official Journal of the Society of Toxicology. 128: 92-102. PMID 22491429 DOI: 10.1093/Toxsci/Kfs131  0.325
2012 Sankpal UT, Abdelrahim M, Connelly SF, Lee CM, Madero-Visbal R, Colon J, Smith J, Safe S, Maliakal P, Basha R. Small molecule tolfenamic acid inhibits PC-3 cell proliferation and invasion in vitro, and tumor growth in orthotopic mouse model for prostate cancer. The Prostate. 72: 1648-58. PMID 22473873 DOI: 10.1002/Pros.22518  0.419
2012 Li X, Lee SO, Safe S. Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3'-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells. Biochemical Pharmacology. 83: 1445-55. PMID 22405837 DOI: 10.1016/J.Bcp.2012.02.021  0.456
2012 Chadalapaka G, Jutooru I, Safe S. Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells. Carcinogenesis. 33: 886-94. PMID 22334592 DOI: 10.1093/Carcin/Bgs102  0.78
2012 Park YY, Kim K, Kim SB, Hennessy BT, Kim SM, Park ES, Lim JY, Li J, Lu Y, Gonzalez-Angulo AM, Jeong W, Mills GB, Safe S, Lee JS. Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer. Embo Molecular Medicine. 4: 52-67. PMID 22174013 DOI: 10.1002/Emmm.201100187  0.746
2012 Lee SO, Andey T, Jin UH, Kim K, Singh M, Sachdeva M, Safe S. The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53. Oncogene. 31: 3265-76. PMID 22081070 DOI: 10.1038/Onc.2011.504  0.761
2012 Zhang S, Kim K, Jin UH, Pfent C, Cao H, Amendt B, Liu X, Wilson-Robles H, Safe S. Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells. Molecular Cancer Therapeutics. 11: 108-18. PMID 22034498 DOI: 10.1158/1535-7163.Mct-11-0548  0.721
2012 Li Z, Chadalapaka G, Ramesh A, Khoshbouei H, Maguire M, Safe S, Rhoades RE, Clark R, Jules G, McCallister M, Aschner M, Hood DB. PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. Toxicological Sciences : An Official Journal of the Society of Toxicology. 125: 233-47. PMID 21987461 DOI: 10.1093/Toxsci/Kfr261  0.303
2012 Kim K, Chadalapaka G, Lee SO, Yamada D, Sastre-Garau X, Defossez PA, Park YY, Lee JS, Safe S. Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer. Oncogene. 31: 1034-44. PMID 21765466 DOI: 10.1038/Onc.2011.296  0.715
2012 Maliakal P, Abdelrahim M, Sankpal UT, Maliakal C, Baker CH, Safe S, Herrera LJ, Abudayyeh A, Kaja S, Basha R. Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats. Investigational New Drugs. 30: 853-61. PMID 21197621 DOI: 10.1007/S10637-010-9622-0  0.369
2012 Yao C, Safe S. The interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in chick embryo hepatocytes. Toxicology in Vitro : An International Journal Published in Association With Bibra. 6: 373-80. PMID 20732135 DOI: 10.1016/0887-2333(92)90028-P  0.305
2012 Patel AR, Lim E, Zhang N, Francis K, Safe S, Sachdeva M. Abstract 382: In-vivo imaging of lung cancer using tumor homing peptide coated nanoparticles Cancer Research. 72: 382-382. DOI: 10.1158/1538-7445.Am2012-382  0.343
2012 Singh M, Andey T, Singh S, Patel AR, Godugu C, Safe S, Chellappan S. Abstract 3361: Sensitization of chemoresistant H1650 lung cancer stem cells to chemotherapy by combination treatment with novel diindolylmethane compounds Cancer Research. 72: 3361-3361. DOI: 10.1158/1538-7445.Am2012-3361  0.404
2012 Kim K, Safe S. Abstract 203: Hotair, a long non-coding RNA, exhibits pro-oncogenic activity in pancreatic cancer Cancer Research. 72: 203-203. DOI: 10.1158/1538-7445.Am2012-203  0.683
2011 Sreevalsan S, Joseph S, Jutooru I, Chadalapaka G, Safe SH. Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent. Anticancer Research. 31: 3799-807. PMID 22110202  0.73
2011 Pathi SS, Lei P, Sreevalsan S, Chadalapaka G, Jutooru I, Safe S. Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. Nutrition and Cancer. 63: 1133-42. PMID 21919647 DOI: 10.1080/01635581.2011.605984  0.843
2011 Chintharlapalli S, Papineni S, Lei P, Pathi S, Safe S. Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors. Bmc Cancer. 11: 371. PMID 21864401 DOI: 10.1186/1471-2407-11-371  0.834
2011 Shin JA, Shim JH, Choi ES, Leem DH, Kwon KH, Lee SO, Safe S, Cho NP, Cho SD. Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (Ecp). 20: 417-25. PMID 21597379 DOI: 10.1097/Cej.0B013E32834473C3  0.403
2011 Yoon K, Lee SO, Cho SD, Kim K, Khan S, Safe S. Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors. Carcinogenesis. 32: 836-42. PMID 21362629 DOI: 10.1093/Carcin/Bgr040  0.809
2011 Abdelbaqi K, Lack N, Guns ET, Kotha L, Safe S, Sanderson JT. Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells. The Prostate. 71: 1401-12. PMID 21321979 DOI: 10.1002/Pros.21356  0.794
2011 Chintharlapalli S, Papineni S, Lee SO, Lei P, Jin UH, Sherman SI, Santarpia L, Safe S. Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins. Molecular Carcinogenesis. 50: 655-67. PMID 21268135 DOI: 10.1002/Mc.20738  0.836
2011 Lee SO, Li X, Khan S, Safe S. Targeting NR4A1 (TR3) in cancer cells and tumors. Expert Opinion On Therapeutic Targets. 15: 195-206. PMID 21204731 DOI: 10.1517/14728222.2011.547481  0.648
2011 Basha R, Baker CH, Sankpal UT, Ahmad S, Safe S, Abbruzzese JL, Abdelrahim M. Therapeutic applications of NSAIDS in cancer: special emphasis on tolfenamic acid. Frontiers in Bioscience (Scholar Edition). 3: 797-805. PMID 21196413 DOI: 10.2741/S188  0.319
2011 Kim K, Burghardt R, Barhoumi R, Lee SO, Liu X, Safe S. MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cells. Journal of Molecular Endocrinology. 46: 67-79. PMID 21169420 DOI: 10.1677/Jme-10-0110  0.751
2011 Pathi SS, Jutooru I, Chadalapaka G, Sreevalsan S, Anand S, Thatcher GR, Safe S. GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. Molecular Cancer Research : McR. 9: 195-202. PMID 21156786 DOI: 10.1158/1541-7786.Mcr-10-0363  0.837
2011 Colon J, Basha MR, Madero-Visbal R, Konduri S, Baker CH, Herrera LJ, Safe S, Sheikh-Hamad D, Abudayyeh A, Alvarado B, Abdelrahim M. Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice. Investigational New Drugs. 29: 41-51. PMID 19851711 DOI: 10.1007/S10637-009-9331-8  0.448
2011 Lee S, Andey T, Jin U, Kim K, Singh M, Safe S. Abstract 4009: Regulation of mTOR pathway by the orphan nuclear receptor NR4A1 (TR3/Nur77) in non-small cell lung cancer: Role of TR3 in AMPK activation Cellular and Molecular Biology. 71: 4009-4009. DOI: 10.1158/1538-7445.Am2011-4009  0.725
2011 Park Y, Kim K, Kim S, Hennessy B, Kim SM, Park ES, Lim JY, Li J, Lu Y, Gonzalez-Angulo A, Mills G, Safe S, Lee J. Abstract 356: Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer Cancer Research. 71: 356-356. DOI: 10.1158/1538-7445.Am2011-356  0.44
2010 Vanderlaag K, Su Y, Frankel AE, Burghardt RC, Barhoumi R, Chadalapaka G, Jutooru I, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer. Bmc Cancer. 10: 669. PMID 21129193 DOI: 10.1186/1471-2407-10-669  0.779
2010 Ichite N, Chougule M, Patel AR, Jackson T, Safe S, Singh M. Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer. Molecular Cancer Therapeutics. 9: 3003-14. PMID 20978159 DOI: 10.1158/1535-7163.Mct-09-1104  0.332
2010 Ortholan C, Durivault J, Hannoun-Levi JM, Guyot M, Bourcier C, Ambrosetti D, Safe S, Pagès G. Bevacizumab/docetaxel association is more efficient than docetaxel alone in reducing breast and prostate cancer cell growth: a new paradigm for understanding the therapeutic effect of combined treatment. European Journal of Cancer (Oxford, England : 1990). 46: 3022-36. PMID 20729074 DOI: 10.1016/J.Ejca.2010.07.021  0.383
2010 Lee SO, Abdelrahim M, Yoon K, Chintharlapalli S, Papineni S, Kim K, Wang H, Safe S. Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth. Cancer Research. 70: 6824-36. PMID 20660371 DOI: 10.1158/0008-5472.Can-10-1992  0.835
2010 Safe S. 3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters. Toxicological Sciences : An Official Journal of the Society of Toxicology. 117: 1-3. PMID 20651249 DOI: 10.1093/Toxsci/Kfq193  0.419
2010 Pang X, Zhang L, Wu Y, Lin L, Li J, Qu W, Safe S, Liu M. Methyl 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor. The Journal of Pharmacology and Experimental Therapeutics. 335: 172-9. PMID 20631299 DOI: 10.1124/Jpet.110.171066  0.415
2010 Jutooru I, Chadalapaka G, Lei P, Safe S. Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. The Journal of Biological Chemistry. 285: 25332-44. PMID 20538607 DOI: 10.1074/Jbc.M109.095240  0.796
2010 Tsao T, Kornblau S, Safe S, Watt JC, Ruvolo V, Chen W, Qiu Y, Coombes KR, Ju Z, Abdelrahim M, Schober W, Ling X, Kardassis D, Meyer C, Schimmer A, et al. Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia. Cancer Research. 70: 4949-60. PMID 20501850 DOI: 10.1158/0008-5472.Can-09-1962  0.449
2010 Jutooru I, Chadalapaka G, Abdelrahim M, Basha MR, Samudio I, Konopleva M, Andreeff M, Safe S. Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a. Molecular Pharmacology. 78: 226-36. PMID 20488920 DOI: 10.1124/Mol.110.064451  0.832
2010 Jutooru I, Chadalapaka G, Sreevalsan S, Lei P, Barhoumi R, Burghardt R, Safe S. Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Experimental Cell Research. 316: 2174-88. PMID 20435036 DOI: 10.1016/J.Yexcr.2010.04.027  0.791
2010 Chadalapaka G, Jutooru I, Burghardt R, Safe S. Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells. Molecular Cancer Research : McR. 8: 739-50. PMID 20407012 DOI: 10.1158/1541-7786.Mcr-09-0493  0.775
2010 Li X, Mertens-Talcott SU, Zhang S, Kim K, Ball J, Safe S. MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells. Endocrinology. 151: 2462-73. PMID 20382698 DOI: 10.1210/En.2009-1150  0.724
2010 Cho SD, Lee SO, Chintharlapalli S, Abdelrahim M, Khan S, Yoon K, Kamat AM, Safe S. Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth. Molecular Pharmacology. 77: 396-404. PMID 20023005 DOI: 10.1124/Mol.109.061143  0.795
2010 Choi KH, Kim HK, Kim JH, Choi ES, Shin JA, Lee SO, Chintharlapalli S, Safe S, Abdelrahim M, Kong G, Choi HS, Jung JY, Cho HT, Cho NP, Cho SD. The p38 MAPK pathway is critical for 5,5'-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (Ecp). 19: 153-9. PMID 19949342 DOI: 10.1097/Cej.0B013E328333D088  0.729
2010 Guo J, Chintharlapalli S, Lee SO, Cho SD, Lei P, Papineni S, Safe S. Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells. Cancer Chemotherapy and Pharmacology. 66: 141-50. PMID 19823826 DOI: 10.1007/S00280-009-1144-0  0.818
2010 Mahammad RB, Madero-Visbal R, Baker CH, Colon J, Safe S, Abudayyeh A, Abdelrahim M. Abstract 4075: Tolfenamic Acid Inhibits Prostate Cancer Cells Growth and Tumor Development in Orthotopic Mice Cancer Research. 70: 4075-4075. DOI: 10.1158/1538-7445.Am10-4075  0.464
2009 Sreevalsan S, Jutooru I, Chadalapaka G, Walker M, Safe S. 1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells. International Journal of Oncology. 35: 1191-9. PMID 19787275 DOI: 10.3892/Ijo_00000436  0.761
2009 Lee SO, Chintharlapalli S, Liu S, Papineni S, Cho SD, Yoon K, Safe S. p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells. Molecular Cancer Research : McR. 7: 1169-78. PMID 19584258 DOI: 10.1158/1541-7786.Mcr-08-0473  0.841
2009 Chintharlapalli S, Papineni S, Abdelrahim M, Abudayyeh A, Jutooru I, Chadalapaka G, Wu F, Mertens-Talcott S, Vanderlaag K, Cho SD, Smith R, Safe S. Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells. International Journal of Cancer. 125: 1965-74. PMID 19582879 DOI: 10.1002/Ijc.24530  0.815
2009 Zhang S, Lei P, Liu X, Li X, Walker K, Kotha L, Rowlands C, Safe S. The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. Endocrine-Related Cancer. 16: 835-44. PMID 19447902 DOI: 10.1677/Erc-09-0054  0.845
2009 Liu X, Abdelrahim M, Abudayyeh A, Lei P, Safe S. The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression. Molecular Cancer Therapeutics. 8: 1207-17. PMID 19435870 DOI: 10.1158/1535-7163.Mct-08-1097  0.497
2009 Papineni S, Chintharlapalli S, Abdelrahim M, Lee SO, Burghardt R, Abudayyeh A, Baker C, Herrera L, Safe S. Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met. Carcinogenesis. 30: 1193-201. PMID 19406933 DOI: 10.1093/Carcin/Bgp092  0.844
2009 Konduri S, Colon J, Baker CH, Safe S, Abbruzzese JL, Abudayyeh A, Basha MR, Abdelrahim M. Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression. Molecular Cancer Therapeutics. 8: 533-42. PMID 19258429 DOI: 10.1158/1535-7163.Mct-08-0405  0.391
2009 Barhoumi R, Catania JM, Parrish AR, Awooda I, Tiffany-Castiglioni E, Safe S, Burghardt RC. Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines. The Journal of Toxicological Sciences. 34: 13-25. PMID 19182432 DOI: 10.2131/Jts.34.13  0.32
2009 Ichite N, Chougule MB, Jackson T, Fulzele SV, Safe S, Singh M. Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 543-52. PMID 19147759 DOI: 10.1158/1078-0432.Ccr-08-1558  0.386
2009 Jutooru I, Chadalapaka G, Chintharlapalli S, Papineni S, Safe S. Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative. Molecular Carcinogenesis. 48: 692-702. PMID 19125423 DOI: 10.1002/Mc.20518  0.839
2009 Wu F, Ivanov I, Xu R, Safe S. Role of SP transcription factors in hormone-dependent modulation of genes in MCF-7 breast cancer cells: microarray and RNA interference studies. Journal of Molecular Endocrinology. 42: 19-33. PMID 18952783 DOI: 10.1677/Jme-08-0088  0.48
2009 Carbone DL, Popichak KA, Moreno JA, Safe S, Tjalkens RB. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis. Molecular Pharmacology. 75: 35-43. PMID 18840677 DOI: 10.1124/Mol.108.050781  0.341
2008 Inamoto T, Papineni S, Chintharlapalli S, Cho SD, Safe S, Kamat AM. 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Molecular Cancer Therapeutics. 7: 3825-33. PMID 19074857 DOI: 10.1158/1535-7163.Mct-08-0730  0.837
2008 Lee SH, Bahn JH, Choi CK, Whitlock NC, English AE, Safe S, Baek SJ. ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells. Molecular Cancer Therapeutics. 7: 3739-50. PMID 19074849 DOI: 10.1158/1535-7163.Mct-08-0548  0.436
2008 Lei P, Abdelrahim M, Cho SD, Liu X, Liu X, Safe S. Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3'-indoly)-1-(p-substituted phenyl)methanes. Molecular Cancer Therapeutics. 7: 3363-72. PMID 18852139 DOI: 10.1158/1535-7163.Mct-08-0439  0.479
2008 Safe S, Kim K, Kim K. Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways. Journal of Molecular Endocrinology. 41: 263-75. PMID 18772268 DOI: 10.1677/Jme-08-0103  0.74
2008 Cho SD, Chintharlapalli S, Abdelrahim M, Papineni S, Liu S, Guo J, Lei P, Abudayyeh A, Safe S. 5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells. Molecular Cancer Therapeutics. 7: 2109-20. PMID 18645021 DOI: 10.1158/1535-7163.Mct-07-2311  0.828
2008 Wu F, Xu R, Kim K, Martin J, Safe S. In vivo profiling of estrogen receptor/specificity protein-dependent transactivation. Endocrinology. 149: 5696-705. PMID 18635651 DOI: 10.1210/En.2008-0720  0.763
2008 Chadalapaka G, Jutooru I, Chintharlapalli S, Papineni S, Smith R, Li X, Safe S. Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Research. 68: 5345-54. PMID 18593936 DOI: 10.1158/0008-5472.Can-07-6805  0.839
2008 Safe S, Papineni S, Chintharlapalli S. Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs. Cancer Letters. 269: 326-38. PMID 18501502 DOI: 10.1016/J.Canlet.2008.04.021  0.844
2008 Lei P, Abdelrahim M, Cho SD, Liu S, Chintharlapalli S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase. Carcinogenesis. 29: 1139-47. PMID 18460448 DOI: 10.1093/Carcin/Bgn103  0.736
2008 Wu F, Khan S, Wu Q, Barhoumi R, Burghardt R, Safe S. Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens. The Journal of Steroid Biochemistry and Molecular Biology. 110: 104-15. PMID 18400491 DOI: 10.1016/J.Jsbmb.2008.02.008  0.702
2008 Chadalapaka G, Jutooru I, McAlees A, Stefanac T, Safe S. Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. Bioorganic & Medicinal Chemistry Letters. 18: 2633-9. PMID 18359628 DOI: 10.1016/J.Bmcl.2008.03.031  0.74
2008 Hong J, Samudio I, Chintharlapalli S, Safe S. 1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines. Molecular Carcinogenesis. 47: 492-507. PMID 18085536 DOI: 10.1002/Mc.20407  0.779
2008 Zhang S, Rowlands C, Safe S. Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay. Toxicology and Applied Pharmacology. 227: 196-206. PMID 18048071 DOI: 10.1016/J.Taap.2007.10.019  0.487
2008 Tjalkens RB, Liu X, Mohl B, Wright T, Moreno JA, Carbone DL, Safe S. The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells. Journal of Neuroscience Research. 86: 618-29. PMID 18041089 DOI: 10.1002/Jnr.21524  0.399
2008 York M, Abdelrahim M, Chintharlapalli S, Lucero SD, Safe S. 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce apoptosis and inhibit renal cell carcinoma growth. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 6743-52. PMID 18006776 DOI: 10.1158/1078-0432.Ccr-07-0967  0.717
2008 Higgins KJ, Liu S, Abdelrahim M, Vanderlaag K, Liu X, Porter W, Metz R, Safe S. Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast cancer cells by estrogen receptor alpha/Sp proteins. Molecular Endocrinology (Baltimore, Md.). 22: 388-402. PMID 18006642 DOI: 10.1210/Me.2007-0319  0.845
2008 Papineni S, Chintharlapalli S, Safe S. Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells. Molecular Pharmacology. 73: 553-65. PMID 17989348 DOI: 10.1124/Mol.107.041285  0.82
2008 Cho SD, Lei P, Abdelrahim M, Yoon K, Liu S, Guo J, Papineni S, Chintharlapalli S, Safe S. 1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells. Molecular Carcinogenesis. 47: 252-63. PMID 17957723 DOI: 10.1002/Mc.20378  0.826
2008 Vanderlaag K, Su Y, Frankel AE, Grage H, Smith R, Khan S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways. Breast Cancer Research and Treatment. 109: 273-83. PMID 17624585 DOI: 10.1007/S10549-007-9648-Y  0.694
2008 Lei P, Abdelrahim M, Cho SD, Liu X, Safe S. Structure-dependent activation of endoplasmic reticulum stress_mediated apoptosis in pancreatic cancer by 1,1-bis(3′-indoly)-1-(p_substituted phenyl)methanes (Molecular Cancer Therapeutics (2008) 7, (3363-3372)) Molecular Cancer Therapeutics. 7. DOI: 10.1158/1535-7163.Mct-7-11-Cor4  0.382
2007 Mertens-Talcott SU, Chintharlapalli S, Li X, Safe S. The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Research. 67: 11001-11. PMID 18006846 DOI: 10.1158/0008-5472.Can-07-2416  0.719
2007 Khan S, Wu F, Liu S, Wu Q, Safe S. Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells. Journal of Molecular Endocrinology. 39: 289-304. PMID 17909268 DOI: 10.1677/Jme-07-0043  0.72
2007 Su Y, Vanderlaag K, Ireland C, Ortiz J, Grage H, Safe S, Frankel AE. 1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice. Breast Cancer Research : Bcr. 9: R56. PMID 17764562 DOI: 10.1186/Bcr1761  0.832
2007 Chintharlapalli S, Papineni S, Liu S, Jutooru I, Chadalapaka G, Cho SD, Murthy RS, You Y, Safe S. 2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells. Carcinogenesis. 28: 2337-46. PMID 17724373 DOI: 10.1093/Carcin/Bgm189  0.832
2007 Khan S, Liu S, Stoner M, Safe S. Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells Toxicology and Applied Pharmacology. 223: 28-38. PMID 17599377 DOI: 10.1016/J.Taap.2007.05.010  0.851
2007 Reddivari L, Vanamala J, Chintharlapalli S, Safe SH, Miller JC. Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways. Carcinogenesis. 28: 2227-35. PMID 17522067 DOI: 10.1093/Carcin/Bgm117  0.68
2007 Chintharlapalli S, Papineni S, Jutooru I, McAlees A, Safe S. Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells. Molecular Cancer Therapeutics. 6: 1588-98. PMID 17513608 DOI: 10.1158/1535-7163.Mct-07-0022  0.835
2007 Abdelrahim M, Baker CH, Abbruzzese JL, Sheikh-Hamad D, Liu S, Cho SD, Yoon K, Safe S. Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. Cancer Research. 67: 3286-94. PMID 17409437 DOI: 10.1158/0008-5472.Can-06-3831  0.491
2007 Chintharlapalli S, Papineni S, Ramaiah SK, Safe S. Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Research. 67: 2816-23. PMID 17363604 DOI: 10.1158/0008-5472.Can-06-3735  0.824
2007 Lee J, Safe S. Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150). Archives of Biochemistry and Biophysics. 461: 200-10. PMID 17306756 DOI: 10.1016/J.Abb.2006.12.030  0.458
2007 Cho SD, Yoon K, Chintharlapalli S, Abdelrahim M, Lei P, Hamilton S, Khan S, Ramaiah SK, Safe S. Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. Cancer Research. 67: 674-83. PMID 17234778 DOI: 10.1158/0008-5472.Can-06-2907  0.8
2007 Wu F, Safe S. Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 103: 1-9. PMID 17141713 DOI: 10.1016/J.Jsbmb.2006.07.007  0.461
2007 Chintharlapalli S, Papineni S, Safe S. 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes inhibit growth, induce apoptosis, and decrease the androgen receptor in LNCaP prostate cancer cells through peroxisome proliferator-activated receptor gamma-independent pathways. Molecular Pharmacology. 71: 558-69. PMID 17093136 DOI: 10.1124/Mol.106.028696  0.831
2006 Lei P, Abdelrahim M, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator-activated receptor-dependent and independent pathways. Molecular Cancer Therapeutics. 5: 2324-36. PMID 16985067 DOI: 10.1158/1535-7163.Mct-06-0184  0.497
2006 Liu S, Abdelrahim M, Khan S, Ariazi E, Jordan VC, Safe S. Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells. Biological Chemistry. 387: 1209-13. PMID 16972788 DOI: 10.1515/Bc.2006.149  0.677
2006 Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws L, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, et al. The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicological Sciences : An Official Journal of the Society of Toxicology. 93: 223-41. PMID 16829543 DOI: 10.1093/Toxsci/Kfl055  0.305
2006 Safe S, Papineni S. The role of xenoestrogenic compounds in the development of breast cancer. Trends in Pharmacological Sciences. 27: 447-54. PMID 16822555 DOI: 10.1016/J.Tips.2006.06.006  0.728
2006 Abdelrahim M, Baker CH, Abbruzzese JL, Safe S. Tolfenamic Acid and Pancreatic Cancer Growth, Angiogenesis, and Sp Protein Degradation Journal of the National Cancer Institute. 98: 855-868. PMID 16788159 DOI: 10.1093/Jnci/Djj232  0.451
2006 Khan S, Konstantinov A, Chittim B, McAlees A, Yeo B, Safe S. Structure-dependent Ah receptor agonist activities of chlorinated biphenylenes. Toxicology in Vitro : An International Journal Published in Association With Bibra. 20: 1234-7. PMID 16759834 DOI: 10.1016/J.Tiv.2006.04.003  0.704
2006 Chintharlapalli S, Papineni S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways. Molecular Cancer Therapeutics. 5: 1362-70. PMID 16731770 DOI: 10.1158/1535-7163.Mct-06-0002  0.844
2006 Higgins KJ, Abdelrahim M, Liu S, Yoon K, Safe S. Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins. Biochemical and Biophysical Research Communications. 345: 292-301. PMID 16678129 DOI: 10.1016/J.Bbrc.2006.04.111  0.831
2006 Khan S, Barhoumi R, Burghardt R, Liu S, Kim K, Safe S. Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells. Molecular Endocrinology (Baltimore, Md.). 20: 2199-214. PMID 16675542 DOI: 10.1210/Me.2006-0100  0.826
2006 Ru Lee W, Chen CC, Liu S, Safe S. 17beta-estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways. Journal of Cellular Biochemistry. 99: 209-20. PMID 16598773 DOI: 10.1002/Jcb.20902  0.684
2006 Higgins KJ, Liu S, Abdelrahim M, Yoon K, Vanderlaag K, Porter W, Metz RP, Safe S. Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins. Endocrinology. 147: 3285-95. PMID 16574784 DOI: 10.1210/En.2006-0081  0.842
2006 Konopleva M, Zhang W, Shi YX, McQueen T, Tsao T, Abdelrahim M, Munsell MF, Johansen M, Yu D, Madden T, Safe SH, Hung MC, Andreeff M. Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells. Molecular Cancer Therapeutics. 5: 317-28. PMID 16505105 DOI: 10.1158/1535-7163.Mct-05-0350  0.368
2006 Abdelrahim M, Ariazi E, Kim K, Khan S, Barhoumi R, Burghardt R, Liu S, Hill D, Finnell R, Wlodarczyk B, Jordan VC, Safe S. 3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha. Cancer Research. 66: 2459-67. PMID 16489053 DOI: 10.1158/0008-5472.Can-05-3132  0.784
2006 Li X, Zhang S, Safe S. Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds. The Journal of Steroid Biochemistry and Molecular Biology. 98: 122-32. PMID 16413991 DOI: 10.1016/J.Jsbmb.2005.08.018  0.371
2006 Kassouf W, Chintharlapalli S, Abdelrahim M, Nelkin G, Safe S, Kamat AM. Inhibition of bladder tumor growth by 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes: a new class of peroxisome proliferator-activated receptor gamma agonists. Cancer Research. 66: 412-8. PMID 16397256 DOI: 10.1158/0008-5472.Can-05-2755  0.738
2006 Samudio I, Konopleva M, Safe S, McQueen T, Andreeff M. Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure. Molecular Cancer Therapeutics. 4: 1982-92. PMID 16373713 DOI: 10.1158/1535-7163.Mct-05-0247  0.63
2006 Abdelrahim M, Newman K, Vanderlaag K, Samudio I, Safe S. 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. Carcinogenesis. 27: 717-28. PMID 16332727 DOI: 10.1093/Carcin/Bgi270  0.697
2006 Mitchell DC, Abdelrahim M, Weng J, Stafford LJ, Safe S, Bar-Eli M, Liu M. Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-2alpha and specificity protein-1. The Journal of Biological Chemistry. 281: 51-8. PMID 16260418 DOI: 10.1074/Jbc.M506245200  0.443
2005 Lee SH, Yamaguchi K, Kim JS, Eling TE, Safe S, Park Y, Baek SJ. Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis. 27: 972-81. PMID 16286461 DOI: 10.1093/Carcin/Bgi268  0.406
2005 Fleming JG, Spencer TE, Safe SH, Bazer FW. Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements. Endocrinology. 147: 899-911. PMID 16254027 DOI: 10.1210/En.2005-1120  0.342
2005 Safe S, Abdelrahim M. Sp transcription factor family and its role in cancer. European Journal of Cancer (Oxford, England : 1990). 41: 2438-48. PMID 16209919 DOI: 10.1016/J.Ejca.2005.08.006  0.419
2005 Calabrò P, Samudio I, Safe SH, Willerson JT, Yeh ET. Inhibition of tumor-necrosis-factor-alpha induced endothelial cell activation by a new class of PPAR-gamma agonists. An in vitro study showing receptor-independent effects. Journal of Vascular Research. 42: 509-16. PMID 16155367 DOI: 10.1159/000088260  0.615
2005 Chintharlapalli S, Papineni S, Baek SJ, Liu S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1. Molecular Pharmacology. 68: 1782-92. PMID 16155208 DOI: 10.1124/Mol.105.017046  0.842
2005 Samudio I, Konopleva M, Hail N, Shi YX, McQueen T, Hsu T, Evans R, Honda T, Gribble GW, Sporn M, Gilbert HF, Safe S, Andreeff M. 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. The Journal of Biological Chemistry. 280: 36273-82. PMID 16118208 DOI: 10.1074/Jbc.M507518200  0.637
2005 Vanderlaag K, Samudio I, Burghardt R, Barhoumi R, Safe S. Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM. Cancer Letters. 236: 198-212. PMID 16051428 DOI: 10.1016/J.Canlet.2005.05.036  0.694
2005 Abdelrahim M, Safe S. Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins. Molecular Pharmacology. 68: 317-29. PMID 15883203 DOI: 10.1124/mol.105.011825  0.358
2005 Chintharlapalli S, Burghardt R, Papineni S, Ramaiah S, Yoon K, Safe S. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. The Journal of Biological Chemistry. 280: 24903-14. PMID 15871945 DOI: 10.1074/Jbc.M500107200  0.849
2005 Safe S. Clinical correlates of environmental endocrine disruptors. Trends in Endocrinology and Metabolism: Tem. 16: 139-44. PMID 15860409 DOI: 10.1016/J.Tem.2005.03.004  0.304
2005 Contractor R, Samudio IJ, Estrov Z, Harris D, McCubrey JA, Safe SH, Andreeff M, Konopleva M. A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia. Cancer Research. 65: 2890-8. PMID 15805291 DOI: 10.1158/0008-5472.Can-04-3781  0.648
2005 Chintharlapalli S, Papineni S, Konopleva M, Andreef M, Samudio I, Safe S. 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways. Molecular Pharmacology. 68: 119-28. PMID 15798084 DOI: 10.1124/Mol.105.011437  0.842
2005 Abdelrahim M, Liu S, Safe S. Induction of endoplasmic reticulum-induced stress genes in Panc-1 pancreatic cancer cells is dependent on Sp proteins. The Journal of Biological Chemistry. 280: 16508-13. PMID 15760841 DOI: 10.1074/Jbc.C500030200  0.429
2005 Kim K, Barhoumi R, Burghardt R, Safe S. Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer. Molecular Endocrinology (Baltimore, Md.). 19: 843-54. PMID 15637147 DOI: 10.1210/Me.2004-0326  0.766
2005 Lee JE, Kim K, Sacchettini JC, Smith CV, Safe S. DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs. The Journal of Biological Chemistry. 280: 8819-30. PMID 15625066 DOI: 10.1074/Jbc.M413184200  0.743
2005 Samudio I, Konopleva M, Safe S, Andreeff M. Guggulsterones Induce Apoptosis and Differentiation in AML: Identification of Isomer-Specific Antileukemic Activities of the Pregnanedienedione Structure. Blood. 106: 4466-4466. DOI: 10.1182/Blood.V106.11.4466.4466  0.644
2005 Kassouf W, Safe S, Abdelrahim M, Chintharlapalli S, Nelkin GM, Kamat AM. 778: Activity of Novel Agonists of Peroxisome Proliferator-Activated Receptor Gamma (Ppargamma) Against Human Transitional Cell Tumors Journal of Urology. 173: 211-211. DOI: 10.1016/S0022-5347(18)34947-4  0.695
2004 Fretland AJ, Safe S, Hankinson O. Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7. Chemico-Biological Interactions. 150: 161-70. PMID 15535986 DOI: 10.1016/J.Cbi.2004.09.007  0.46
2004 Wu Q, Burghardt R, Safe S. Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins. The Journal of Biological Chemistry. 279: 53602-12. PMID 15471764 DOI: 10.1074/Jbc.M409778200  0.505
2004 Safe S. Endocrine disruptors and human health: is there a problem. Toxicology. 205: 3-10. PMID 15458784 DOI: 10.1016/J.Tox.2004.06.032  0.346
2004 Chen CC, Lee WR, Safe S. Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1. Journal of Cellular Biochemistry. 93: 1063-74. PMID 15449318 DOI: 10.1002/Jcb.20257  0.842
2004 Abdelrahim M, Smith R, Burghardt R, Safe S. Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells. Cancer Research. 64: 6740-9. PMID 15374992 DOI: 10.1158/0008-5472.Can-04-0713  0.463
2004 Hong J, Samudio I, Liu S, Abdelrahim M, Safe S. Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins. Endocrinology. 145: 5774-85. PMID 15345676 DOI: 10.1210/En.2004-0686  0.708
2004 Chintharlapalli S, Smith R, Samudio I, Zhang W, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome proliferator-activated receptor gamma-mediated growth inhibition, transactivation, and differentiation markers in colon cancer cells. Cancer Research. 64: 5994-6001. PMID 15342379 DOI: 10.1158/0008-5472.Can-04-0399  0.794
2004 Li X, Qin C, Burghardt R, Safe S. Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells. Biochemical and Biophysical Research Communications. 320: 625-34. PMID 15240094 DOI: 10.1016/J.Bbrc.2004.05.205  0.762
2004 Qin C, Samudio I, Ngwenya S, Safe S. Estrogen-dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways. Molecular Carcinogenesis. 40: 160-70. PMID 15224348 DOI: 10.1002/Mc.20030  0.834
2004 Safe S, Kim K. Nuclear receptor-mediated transactivation through interaction with Sp proteins. Progress in Nucleic Acid Research and Molecular Biology. 77: 1-36. PMID 15196889 DOI: 10.1016/S0079-6603(04)77001-4  0.715
2004 Pearce ST, Liu H, Radhakrishnan I, Abdelrahim M, Safe S, Jordan VC. Interaction of the aryl hydrocarbon receptor ligand 6-methyl-1,3,8-trichlorodibenzofuran with estrogen receptor alpha. Cancer Research. 64: 2889-97. PMID 15087408 DOI: 10.1158/0008-5472.Can-03-1770  0.475
2004 Qin C, Morrow D, Stewart J, Spencer K, Porter W, Smith R, Phillips T, Abdelrahim M, Samudio I, Safe S. A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. Molecular Cancer Therapeutics. 3: 247-60. PMID 15026545  0.834
2004 Morrow D, Qin C, Smith R, Safe S. Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation. The Journal of Steroid Biochemistry and Molecular Biology. 88: 27-36. PMID 15026081 DOI: 10.1016/J.Jsbmb.2003.10.005  0.777
2004 Safe S, Wormke M, Samudio I. Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells. Journal of Mammary Gland Biology and Neoplasia. 5: 295-306. PMID 14973392 DOI: 10.1023/A:1009550912337  0.855
2004 Corbin CJ, Mapes SM, Marcos J, Shackleton CH, Morrow D, Safe S, Wise T, Ford JJ, Conley AJ. Paralogues of porcine aromatase cytochrome P450: a novel hydroxylase activity is associated with the survival of a duplicated gene. Endocrinology. 145: 2157-64. PMID 14962994 DOI: 10.1210/En.2003-1595  0.328
2004 Stoner M, Wormke M, Saville B, Samudio I, Qin C, Abdelrahim M, Safe S. Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins. Oncogene. 23: 1052-63. PMID 14647449 DOI: 10.1038/Sj.Onc.1207201  0.842
2004 Safe S, Wormke M. Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action. Chemical Research in Toxicology. 16: 807-16. PMID 12870882 DOI: 10.1021/Tx034036R  0.78
2004 Contractor R, Samudio IJ, Estrov Z, Harris D, McCubrey JA, Safe SH, Andreeff M, Konopleva M. A Novel Ring-Substituted Diindolylmethane 1,1-bis [3′-(5-methoxyindolyl)]-1-(p-t-butylphenyl) Methane Abrogates ERK Activation and Induces Apoptosis in Acute Myeloid Leukemia (AML). Blood. 104: 3399-3399. DOI: 10.1182/Blood.V104.11.3399.3399  0.635
2003 Zhang S, Qin C, Safe SH. Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. Environmental Health Perspectives. 111: 1877-82. PMID 14644660 DOI: 10.1289/Ehp.6322  0.754
2003 Safe S. Cadmium's disguise dupes the estrogen receptor. Nature Medicine. 9: 1000-1. PMID 12894163 DOI: 10.1038/Nm0803-1000  0.358
2003 Abdelrahim M, Smith R, Safe S. Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells. Molecular Pharmacology. 63: 1373-81. PMID 12761348 DOI: 10.1124/Mol.63.6.1373  0.479
2003 Khan S, Abdelrahim M, Samudio I, Safe S. Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells. Endocrinology. 144: 2325-35. PMID 12746293 DOI: 10.1210/En.2002-0149  0.792
2003 Ngwenya S, Safe S. Cell context-dependent differences in the induction of E2F-1 gene expression by 17 beta-estradiol in MCF-7 and ZR-75 cells. Endocrinology. 144: 1675-85. PMID 12697671 DOI: 10.1210/En.2002-0009  0.842
2003 Castro-Rivera E, Safe S. 17 beta-estradiol- and 4-hydroxytamoxifen-induced transactivation in breast, endometrial and liver cancer cells is dependent on ER-subtype, cell and promoter context. The Journal of Steroid Biochemistry and Molecular Biology. 84: 23-31. PMID 12648521 DOI: 10.1016/S0960-0760(03)00010-4  0.437
2003 Qin C, Burghardt R, Smith R, Wormke M, Stewart J, Safe S. Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. Cancer Research. 63: 958-64. PMID 12615709  0.827
2003 Wormke M, Stoner M, Saville B, Walker K, Abdelrahim M, Burghardt R, Safe S. The aryl hydrocarbon receptor mediates degradation of estrogen receptor α through activation of proteasomes Molecular and Cellular Biology. 23: 1843-1855. PMID 12612060 DOI: 10.1128/Mcb.23.6.1843-1855.2003  0.831
2003 Safe S. Environmental estrogens: roles in male reproductive tract problems and in breast cancer. Reviews On Environmental Health. 17: 253-62. PMID 12611468 DOI: 10.1515/Reveh.2002.17.4.253  0.328
2003 Kim K, Thu N, Saville B, Safe S. Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells. Molecular Endocrinology (Baltimore, Md.). 17: 804-17. PMID 12576490 DOI: 10.1210/Me.2002-0406  0.75
2003 Vyhlidal C, Li X, Safe S. Estrogen regulation of transferrin gene expression in MCF-7 human breast cancer cells. Journal of Molecular Endocrinology. 29: 305-17. PMID 12459033 DOI: 10.1677/Jme.0.0290305  0.763
2003 Zhang W, Jiang J, Qin C, Pérez LM, Parrish AR, Safe SH, Simanek EE. Triazine Dendrimers for Drug Delivery: Evaluation of Solubilization Properties, Activity in Cell Culture, and In Vivo Toxicity of a Candidate Vehicle Supramolecular Chemistry. 15: 607-616. DOI: 10.1080/10610270310001605197  0.664
2002 Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, McDonnell D. Problems for risk assessment of endocrine-active estrogenic compounds. Environmental Health Perspectives. 110: 925-9. PMID 12634121 DOI: 10.1289/Ehp.02110S6925  0.361
2002 Stoner M, Saville B, Wormke M, Dean D, Burghardt R, Safe S. Hypoxia induces proteasome-dependent degradation of estrogen receptor α in ZR-75 breast cancer cells Molecular Endocrinology. 16: 2231-2242. PMID 12351689 DOI: 10.1210/Me.2001-0347  0.834
2002 Koliopanos A, Kleeff J, Xiao Y, Safe S, Zimmermann A, Büchler MW, Friess H. Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer. Oncogene. 21: 6059-70. PMID 12203118 DOI: 10.1038/Sj.Onc.1205633  0.459
2002 Qin C, Nguyen T, Stewart J, Samudio I, Burghardt R, Safe S. Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex. Molecular Endocrinology (Baltimore, Md.). 16: 1793-809. PMID 12145335 DOI: 10.1210/Me.2002-0006  0.826
2002 Abdelrahim M, Samudio I, Smith R, Burghardt R, Safe S. Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells. The Journal of Biological Chemistry. 277: 28815-22. PMID 12052832 DOI: 10.1074/Jbc.M203828200  0.713
2002 Duan R, Xie W, Li X, McDougal A, Safe S. Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells. Biochemical and Biophysical Research Communications. 294: 384-94. PMID 12051724 DOI: 10.1016/S0006-291X(02)00499-0  0.805
2002 Safe S, McDougal A. Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review). International Journal of Oncology. 20: 1123-8. PMID 12011988 DOI: 10.3892/Ijo.20.6.1123  0.823
2002 Mealey KL, Barhoumi R, Burghardt RC, Safe S, Kochevar DT. Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells. Antimicrobial Agents and Chemotherapy. 46: 755-61. PMID 11850258 DOI: 10.1128/Aac.46.3.755-761.2002  0.371
2002 Wang F, Samudio I, Safe S. Transcriptional activation of rat creatine kinase B by 17beta-estradiol in MCF-7 cells involves an estrogen responsive element and GC-rich sites. Journal of Cellular Biochemistry. 84: 156-72. PMID 11746525 DOI: 10.1002/Jcb.1276  0.704
2002 Saville B, Poukka H, Wormke M, Jänne OA, Palvimo JJ, Stoner M, Samudio I, Safe S. Cooperative coactivation of estrogen receptor α in ZR-75 human breast cancer cells by SNURF and TATA-binding protein Journal of Biological Chemistry. 277: 2485-2497. PMID 11696545 DOI: 10.1074/Jbc.M109021200  0.822
2001 Samudio I, Vyhlidal C, Wang F, Stoner M, Chen I, Kladde M, Barhoumi R, Burghardt R, Safe S. Transcriptional Activation of Deoxyribonucleic Acid Polymerase α Gene Expression in MCF-7 Cells by 17β-Estradiol. Endocrinology. 142: 1000-1008. PMID 28201425 DOI: 10.1210/Endo.142.3.8022  0.817
2001 Stewart DM, Johnson GA, Vyhlidal CA, Burghardt RC, Safe SH, Yu-Lee LY, Bazer FW, Spencer TE. Interferon-τ Activates Multiple Signal Transducer and Activator of Transcription Proteins and Has Complex Effects on Interferon-Responsive Gene Transcription in Ovine Endometrial Epithelial Cells* * This work was supported by NIH Grant HD-32534 (to F.W.B. and T.E.S.) and in part by NIH Grant P30-ES-09106. The publication costs of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. Endocrinology. 142: 98-107. PMID 28201367 DOI: 10.1210/endo.142.1.7891  0.678
2001 Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, Saville B, McDonnellc D. Toxicology of environmental estrogens. Reproduction, Fertility, and Development. 13: 307-15. PMID 11800169 DOI: 10.1071/Rd00108  0.375
2001 Lee JE, Safe S. Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells Biochemical Pharmacology. 62: 1113-1124. PMID 11597580 DOI: 10.1016/S0006-2952(01)00763-8  0.522
2001 Yoon K, Pallaroni L, Stoner M, Gaido K, Safe S. Differential activation of wild-type and variant forms of estrogen receptor α by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements Journal of Steroid Biochemistry and Molecular Biology. 78: 25-32. PMID 11530281 DOI: 10.1016/S0960-0760(01)00070-X  0.786
2001 Waters KM, Safe S, Gaido KW. Differential gene expression in response to methoxychlor and estradiol through ERα, ERβ, and AR in reproductive tissues of female mice Toxicological Sciences. 63: 47-56. PMID 11509743 DOI: 10.1093/Toxsci/63.1.47  0.397
2001 McDougal A, Gupta MS, Morrow D, Ramamoorthy K, Lee JE, Safe SH. Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats. Breast Cancer Research and Treatment. 66: 147-57. PMID 11437101 DOI: 10.1023/A:1010608000074  0.794
2001 Castro-Rivera E, Samudio I, Safe S. Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements. The Journal of Biological Chemistry. 276: 30853-61. PMID 11410592 DOI: 10.1074/Jbc.M103339200  0.708
2001 McDougal A, Wormke M, Calvin J, Safe S. Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator. Cancer Research. 61: 3902-7. PMID 11358803  0.347
2001 Xie W, Duan R, Safe S. Activation of adenosine deaminase in MCF-7 cells through IGF-estrogen receptor alpha crosstalk. Journal of Molecular Endocrinology. 26: 217-28. PMID 11357058 DOI: 10.1677/Jme.0.0260217  0.621
2001 Safe S. Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions. Vitamins and Hormones. 62: 231-52. PMID 11345900 DOI: 10.1016/S0083-6729(01)62006-5  0.44
2001 Safe S. Molecular biology of the Ah receptor and its role in carcinogenesis. Toxicology Letters. 120: 1-7. PMID 11323156 DOI: 10.1016/S0378-4274(01)00301-0  0.446
2001 Qin C, Wilson C, Blancher C, Taylor M, Safe S, Harris AL. Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 7: 818-23. PMID 11309328  0.746
2001 Sanderson JT, Slobbe L, Lansbergen GW, Safe S, van den Berg M. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 61: 40-8. PMID 11294972 DOI: 10.1093/Toxsci/61.1.40  0.438
2001 Chen I, Hsieh T, Thomas T, Safe S. Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization. Gene. 262: 207-14. PMID 11179685 DOI: 10.1016/S0378-1119(00)00530-8  0.496
2001 Porter W, Wang F, Duan R, Qin C, Castro-Rivera E, Kim K, Safe S. Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists. Journal of Molecular Endocrinology. 26: 31-42. PMID 11174852 DOI: 10.1677/Jme.0.0260031  0.836
2001 Wang F, Samudio I, Safe S. Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Molecular and Cellular Endocrinology. 172: 91-103. PMID 11165043 DOI: 10.1016/S0303-7207(00)00379-8  0.702
2001 Duan R, Xie W, Burghardt RC, Safe S. Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. The Journal of Biological Chemistry. 276: 11590-8. PMID 11145955 DOI: 10.1074/Jbc.M005492200  0.622
2001 Stewart MD, Stewart DM, Johnson GA, Vyhlidal CA, Burghardt RC, Safe SH, Yu-Lee LY, Bazer FW, Spencer TE. Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells. Endocrinology. 142: 98-107. PMID 11145571 DOI: 10.1210/Endo.142.1.7891  0.707
2000 Xie W, Duan R, Chen I, Samudio I, Safe S. Transcriptional Activation of Thymidylate Synthase by 17β-Estradiol in MCF-7 Human Breast Cancer Cells. Endocrinology. 141: 2439-2449. PMID 28201107 DOI: 10.1210/endo.141.7.7538  0.48
2000 Xie W, Barwick JL, Simon CM, Pierce AM, Safe S, Blumberg B, Guzelian PS, Evans RM. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes & Development. 14: 3014-23. PMID 11114890 DOI: 10.1101/Gad.846800  0.536
2000 Lee JE, Safe S. 3′, 4′-Dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells Toxicological Sciences. 58: 235-242. PMID 11099636 DOI: 10.1093/Toxsci/58.2.235  0.496
2000 Gaido KW, Maness SC, McDonnell DP, Dehal SS, Kupfer D, Safe S. Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. Molecular Pharmacology. 58: 852-8. PMID 10999957  0.306
2000 Wormke M, Stoner M, Saville B, Safe S. Crosstalk between estrogen receptor alpha and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteasomes. Febs Letters. 478: 109-12. PMID 10922479 DOI: 10.1016/S0014-5793(00)01830-5  0.846
2000 Xie W, Duan R, Chen I, Samudio I, Safe S. Transcriptional activation of thymidylate synthase by 17beta-estradiol in MCF-7 human breast cancer cells. Endocrinology. 141: 2439-49. PMID 10875244 DOI: 10.1210/Endo.141.7.7538  0.764
2000 Yoon K, Pellaroni L, Ramamoorthy K, Gaido K, Safe S. Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines. Molecular and Cellular Endocrinology. 162: 211-20. PMID 10854714 DOI: 10.1016/S0303-7207(99)00261-0  0.445
2000 Vyhlidal C, Samudio I, Kladde MP, Safe S. Transcriptional activation of transforming growth factor alpha by estradiol: requirement for both a GC-rich site and an estrogen response element half-site. Journal of Molecular Endocrinology. 24: 329-38. PMID 10828826 DOI: 10.1677/Jme.0.0240329  0.809
2000 Wormke M, Castro-Rivera E, Chen I, Safe S. Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 72: 197-207. PMID 10822009 DOI: 10.1016/S0960-0760(00)00030-3  0.842
2000 Stoner M, Wang F, Wormke M, Nguyen T, Samudio I, Vyhlidal C, Marme D, Finkenzeller G, Safe S. Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins. The Journal of Biological Chemistry. 275: 22769-79. PMID 10816575 DOI: 10.1074/Jbc.M002188200  0.835
2000 Wang F, Duan R, Chirgwin J, Safe SH. Transcriptional activation of cathepsin D gene expression by growth factors. Journal of Molecular Endocrinology. 24: 193-202. PMID 10750020 DOI: 10.1677/Jme.0.0240193  0.465
2000 McDougal A, Sethi Gupta M, Ramamoorthy K, Sun G, Safe SH. Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane. Cancer Letters. 151: 169-79. PMID 10738111 DOI: 10.1016/S0304-3835(99)00406-1  0.824
2000 Saville B, Wormke M, Wang F, Nguyen T, Enmark E, Kuiper G, Gustafsson J, Safe S. Ligand-, Cell-, and Estrogen Receptor Subtype (α/β)-dependent Activation at GC-rich (Sp1) Promoter Elements Journal of Biological Chemistry. 275: 5379-5387. PMID 10681512 DOI: 10.1074/Jbc.275.8.5379  0.803
2000 Gaido KW, Maness SC, McDonnell DP, Dehal SS, Kupfer D, Safe S. Interaction of Methoxychlor and Related Compounds with Estrogen Receptor α and β, and Androgen Receptor: Structure-Activity Studies Molecular Pharmacology. 58: 852-858. DOI: 10.1124/Mol.58.4.852  0.414
1999 Qin C, Singh P, Safe S. Transcriptional Activation of Insulin-Like Growth Factor-Binding Protein-4 by 17β-Estradiol in MCF-7 Cells: Role of Estrogen Receptor-Sp1 Complexes. Endocrinology. 140: 2501-2508. PMID 28200910 DOI: 10.1210/endo.140.6.6751  0.725
1999 Xie W, Duan R, Safe S. Estrogen Induces Adenosine Deaminase Gene Expression in MCF-7 Human Breast Cancer Cells: Role of Estrogen Receptor-Sp1 Interactions* *This work was supported by the National Institutes of Health (Grant CA-76636), the Welch Foundation, and the Texas Agricultural Experiment Station. Endocrinology. 140: 219-227. PMID 28200731 DOI: 10.1210/endo.140.1.6394  0.498
1999 Safe S, Qin C, McDougal A. Development of selective aryl hydrocarbon receptor modulators for treatment of breast cancer. Expert Opinion On Investigational Drugs. 8: 1385-96. PMID 15992156 DOI: 10.1517/13543784.8.9.1385  0.846
1999 Gaido KW, Leonard LS, Maness SC, Hall JM, McDonnell DP, Saville B, Safe S. Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. Endocrinology. 140: 5746-53. PMID 10579340 DOI: 10.1210/Endo.140.12.7191  0.439
1999 Safe S, Wargovich MJ, Lamartiniere CA, Mukhtar H. Symposium on mechanisms of action of naturally occurring anticarcinogens Toxicological Sciences. 52: 1-8. PMID 10568692 DOI: 10.1093/Toxsci/52.1.1  0.339
1999 Dong L, Wang W, Wang F, Stoner M, Reed JC, Harigai M, Samudio I, Kladde MP, Vyhlidal C, Safe S. Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells. The Journal of Biological Chemistry. 274: 32099-107. PMID 10542244 DOI: 10.1074/Jbc.274.45.32099  0.846
1999 Letcher RJ, Van Holsteijn I, Drenth HJ, Norstrom RJ, Bergman A, Safe S, Pieters R, Van Den Berg M. Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells Toxicology and Applied Pharmacology. 160: 10-20. PMID 10502498 DOI: 10.1006/Taap.1999.8746  0.416
1999 Duan R, Porter W, Samudio I, Vyhlidal C, Kladde M, Safe S. Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Molecular Endocrinology (Baltimore, Md.). 13: 1511-21. PMID 10478842 DOI: 10.1210/Mend.13.9.0338  0.826
1999 Wang F, Wang W, Safe S. Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl hydrocarbon receptor complex. Biochemistry. 38: 11490-500. PMID 10471301 DOI: 10.1021/Bi982578F  0.429
1999 Fernandez P, Wilson C, Hoivik D, Safe SH. Altered phenotypic characteristics of T47d human breast cancer cells after prolonged growth in estrogen-deficient medium. Cell Biology International. 22: 623-33. PMID 10452832 DOI: 10.1006/cbir.1998.0303  0.322
1999 Wang W, Dong L, Saville B, Safe S. Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions. Molecular Endocrinology (Baltimore, Md.). 13: 1373-87. PMID 10446910 DOI: 10.1210/Mend.13.8.0323  0.461
1999 Castro-Rivera E, Wormke M, Safe S. Estrogen and aryl hydrocarbon responsiveness of ECC-1 endometrial cancer cells. Molecular and Cellular Endocrinology. 150: 11-21. PMID 10411295 DOI: 10.1016/S0303-7207(99)00041-6  0.838
1999 Nguyen TA, Hoivik D, Lee JE, Safe S. Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. Archives of Biochemistry and Biophysics. 367: 250-7. PMID 10395741 DOI: 10.1006/Abbi.1999.1282  0.479
1999 Qin C, Singh P, Safe S. Transcriptional activation of insulin-like growth factor-binding protein-4 by 17beta-estradiol in MCF-7 cells: role of estrogen receptor-Sp1 complexes. Endocrinology. 140: 2501-8. PMID 10342835 DOI: 10.1210/Endo.140.6.6751  0.773
1999 Safe S, Connor K, Gaido K. Methods for xenoestrogen testing. Toxicology Letters. 665-70. PMID 10022332 DOI: 10.1016/S0378-4274(98)00283-5  0.404
1999 Ramamoorthy K, Gupta MS, Sun G, McDougal A, Safe SH. 3,3'4,4'-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells. Carcinogenesis. 20: 115-23. PMID 9934858 DOI: 10.1093/Carcin/20.1.115  0.849
1999 Xie W, Duan R, Safe S. Estrogen induces adenosine deaminase gene expression in MCF-7 human breast cancer cells: role of estrogen receptor-Sp1 interactions. Endocrinology. 140: 219-27. PMID 9886828 DOI: 10.1210/Endo.140.1.6394  0.615
1998 Gupta M, McDougal A, Safe S. Estrogenic and antiestrogenic activities of 16alpha- and 2-hydroxy metabolites of 17beta-estradiol in MCF-7 and T47D human breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 67: 413-9. PMID 10030690 DOI: 10.1016/S0960-0760(98)00135-6  0.794
1998 Safe S, Wang F, Porter W, Duan R, McDougal A. Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicology Letters. 102: 343-7. PMID 10022276 DOI: 10.1016/S0378-4274(98)00331-2  0.83
1998 Gaido K, Dohme L, Wang F, Chen I, Blankvoort B, Ramamoorthy K, Safe S. Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food. Environmental Health Perspectives. 106: 1347-51. PMID 9860891 DOI: 10.1289/Ehp.98106S61347  0.421
1998 Wilson CL, Safe S. Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses. Toxicologic Pathology. 26: 657-71. PMID 9789953 DOI: 10.1177/019262339802600510  0.415
1998 Chen I, McDougal A, Wang F, Safe S. Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis. 19: 1631-9. PMID 9771935 DOI: 10.1093/Carcin/19.9.1631  0.832
1998 Wang W, Smith R, Safe S. Aryl hydrocarbon receptor-mediated antiestrogenicity in MCF-7 cells: modulation of hormone-induced cell cycle enzymes. Archives of Biochemistry and Biophysics. 356: 239-48. PMID 9705214 DOI: 10.1006/Abbi.1998.0782  0.443
1998 Sun G, Porter W, Safe S. Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex. Molecular Endocrinology (Baltimore, Md.). 12: 882-90. PMID 9626663 DOI: 10.1210/Mend.12.6.0125  0.653
1998 Castro-Rivera E, Safe S. Estrogen- and antiestrogen-responsiveness of HEC1A endometrial adenocarcinoma cells in culture. The Journal of Steroid Biochemistry and Molecular Biology. 64: 287-95. PMID 9618030 DOI: 10.1016/S0960-0760(97)00202-1  0.48
1998 Wang F, Hoivik D, Pollenz R, Safe S. Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes. Nucleic Acids Research. 26: 3044-52. PMID 9611253 DOI: 10.1093/Nar/26.12.3044  0.44
1998 Duan R, Porter W, Safe S. Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: role of estrogen receptor Sp1 complex formation. Endocrinology. 139: 1981-90. PMID 9528985 DOI: 10.1210/Endo.139.4.5870  0.517
1998 Vom Saal FS, Welshons WV, Hansen LG, Talbott EO, Zborowski JV, Kuller LH, Gammon MD, Terry MB, Teitelbaum SL, Britton JA, Levin B, Bigsby RM, Steinmetz R, Verma SP, Goldin BR, ... ... Safe S, et al. Organochlorine residues and breast cancer [1] (multiple letters) New England Journal of Medicine. 338: 988-991. PMID 9527606 DOI: 10.1056/Nejm199804023381411  0.335
1998 Safe S. Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds. Teratogenesis, Carcinogenesis, and Mutagenesis. 17: 285-304. PMID 9508738 DOI: 10.1002/(Sici)1520-6866(1997)17:4/5<285::Aid-Tcm11>3.0.Co;2-B  0.309
1998 McDougal A, Safe S. Induction of 16alpha-/2-hydroxyestrone metabolite ratios in MCF-7 cells by pesticides, carcinogens, and antiestrogens does not predict mammary carcinogens. Environmental Health Perspectives. 106: 203-6. PMID 9494123 DOI: 10.1289/Ehp.98106203  0.759
1998 Porter W, Saville B, Hoivik D, Safe S. Functional synergy between the transcription factor Sp1 and the estrogen receptor. Molecular Endocrinology (Baltimore, Md.). 11: 1569-80. PMID 9328340 DOI: 10.1210/Mend.11.11.9916  0.417
1997 McDougal A, Wilson C, Safe S. Induction of estradiol 2-hydroxylase activity in MCF-7 human breast cancer cells by pesticides and carcinogens. Environmental Toxicology and Pharmacology. 3: 195-9. PMID 21781778 DOI: 10.1016/S1382-6689(97)00013-6  0.797
1997 McDougal A, Wilson C, Safe S. Inhibition of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumor growth by aryl hydrocarbon receptor agonists. Cancer Letters. 120: 53-63. PMID 9570386 DOI: 10.1016/S0304-3835(97)00299-1  0.782
1997 Hoivik D, Wilson C, Wang W, Willett K, Barhoumi R, Burghardt R, Safe S. Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells. Archives of Biochemistry and Biophysics. 348: 174-82. PMID 9390189 DOI: 10.1006/Abbi.1997.0380  0.485
1997 Hoivik D, Willett K, Wilson C, Safe S. Estrogen does not inhibit 2,3,7,8-tetrachlorodibenzo-p-dioxinmediated effects in MCF-7 and Hepa 1c1c7 cells Journal of Biological Chemistry. 272: 30270-30274. PMID 9374512 DOI: 10.1074/Jbc.272.48.30270  0.492
1997 Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155). Environmental Health Perspectives. 105: 1238-48. PMID 9370515  0.791
1997 Wang W, Smith R, Burghardt R, Safe SH. 17 beta-Estradiol-mediated growth inhibition of MDA-MB-468 cells stably transfected with the estrogen receptor: cell cycle effects. Molecular and Cellular Endocrinology. 133: 49-62. PMID 9359472 DOI: 10.1016/S0303-7207(97)00142-1  0.332
1997 Ramamoorthy K, Vyhlidal C, Wang F, Chen I, Safe S, McDonnell DP, Leonard LS, Gaido KW. Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. Toxicology and Applied Pharmacology. 147: 93-100. PMID 9356311 DOI: 10.1006/Taap.1997.8281  0.753
1997 Safe S, Connor K, Ramamoorthy K, Gaido K, Maness S. Human exposure to endocrine-active chemicals: hazard assessment problems. Regulatory Toxicology and Pharmacology : Rtp. 26: 52-8. PMID 9339480 DOI: 10.1006/Rtph.1997.1118  0.358
1997 Wilson CL, Thomsen J, Hoivik DJ, Wormke MT, Stanker L, Holtzapple C, Safe SH. Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein. Archives of Biochemistry and Biophysics. 346: 65-73. PMID 9328285 DOI: 10.1006/Abbi.1997.0289  0.818
1997 Earl Gray L, Kelce WR, Wiese T, Tyl R, Gaido K, Cook J, Klinefelter G, Desaulniers D, Wilson E, Zacharewski T, Waller C, Foster P, Laskey J, Reel J, Giesy J, ... ... Safe S, et al. Endocrine Screening Methods Workshop report: Detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms Reproductive Toxicology. 11: 719-750. PMID 9311581 DOI: 10.1016/S0890-6238(97)00025-7  0.312
1997 Connor K, Ramamoorthy K, Moore M, Mustain M, Chen I, Safe S, Zacharewski T, Gillesby B, Joyeux A, Balaguer P. Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships. Toxicology and Applied Pharmacology. 145: 111-23. PMID 9221830 DOI: 10.1006/Taap.1997.8169  0.474
1997 Sun G, Safe S. Antiestrogenic activities of alternate-substituted polychlorinated dibenzofurans in MCF-7 human breast cancer cells. Cancer Chemotherapy and Pharmacology. 40: 239-44. PMID 9219508 DOI: 10.1007/S002800050653  0.625
1997 Wang F, Porter W, Xing W, Archer TK, Safe S. Identification of a functional imperfect estrogen-responsive element in the 5'-promoter region of the human cathepsin D gene. Biochemistry. 36: 7793-801. PMID 9201922 DOI: 10.1021/bi963100j  0.309
1997 Safe SH. Is there an association between exposure to environmental estrogens and breast cancer? Environmental Health Perspectives. 675-8. PMID 9168013 DOI: 10.1289/ehp.97105s3675  0.31
1997 Gillesby BE, Stanostefano M, Porter W, Safe S, Wu ZF, Zacharewski TR. Identification of a motif within the 5' regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression Biochemistry. 36: 6080-6089. PMID 9166778 DOI: 10.1021/Bi962131B  0.678
1997 Wang WL, Porter W, Burghardt R, Safe SH. Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Carcinogenesis. 18: 925-33. PMID 9163677 DOI: 10.1093/Carcin/18.5.925  0.4
1997 Safe SH, Zacharewski T. Organochlorine exposure and risk for breast cancer. Progress in Clinical and Biological Research. 396: 133-45. PMID 9108595  0.316
1997 Ramamoorthy K, Wang F, Chen IC, Norris JD, McDonnell DP, Leonard LS, Gaido KW, Bocchinfuso WP, Korach KS, Safe S. Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. Endocrinology. 138: 1520-7. PMID 9075711 DOI: 10.1210/Endo.138.4.5056  0.464
1997 Nodland KI, Wormke M, Safe S. Inhibition of estrogen-induced activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-7 human breast cancer and other cell lines transfected with vitellogenin A2 gene promoter constructs. Archives of Biochemistry and Biophysics. 338: 67-72. PMID 9015389 DOI: 10.1006/Abbi.1996.9806  0.842
1997 Moore M, Mustain M, Daniel K, Chen I, Safe S, Zacharewski T, Gillesby B, Joyeux A, Balaguer P. Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum. Toxicology and Applied Pharmacology. 142: 160-8. PMID 9007045 DOI: 10.1006/Taap.1996.8022  0.492
1997 Ramamoorthy K, Wang F, Chen IC, Safe S, Norris JD, McDonnell DP, Gaido KW, Korach KS, McLachlan JA, Arnold SF, Klotz DM, Collins BM, Vonier PM, Guillette LJ. Potency of combined estrogenic pesticides Science. 275: 405-406. PMID 9005556 DOI: 10.1126/Science.275.5298.405  0.308
1997 Porter W, Wang F, Wang W, Duan R, Safe S. Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression. Molecular Endocrinology (Baltimore, Md.). 10: 1371-8. PMID 8923463 DOI: 10.1210/Mend.10.11.8923463  0.454
1997 Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. Examination of the Estrogenicity of 2,4,6,2 prime ,6 prime -Pentachlorobiphenyl (PCB 104), Its Hydroxylated Metabolite 2,4,6,2 prime ,6 prime -Pentachloro-4-Biphenylol (HO-PCB 104), and a Further Chlorinated Derivative, 2,4,6,2 prime ,4 prime ,6 prime -Hexachlorobiphenyl (PCB 155) Environmental Health Perspectives. 105: 1238. DOI: 10.2307/3433904  0.709
1997 Safe SH, McDougal A. Environmental factors and breast cancer Endocrine Related Cancer. 4: 113-123. DOI: 10.1677/Erc.0.0040113  0.752
1996 Lu YF, Santostefano M, Cunningham BD, Threadgill MD, Safe S. Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists. Biochemical Pharmacology. 51: 1077-87. PMID 8866830 DOI: 10.1016/0006-2952(96)00063-9  0.429
1996 Chen I, Safe S, Bjeldanes L. Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells. Biochemical Pharmacology. 51: 1069-76. PMID 8866829 DOI: 10.1016/0006-2952(96)00060-3  0.412
1996 Connor K, Howell J, Chen I, Liu H, Berhane K, Sciarretta C, Safe S, Zacharewski T. Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro Fundamental and Applied Toxicology. 30: 93-101. PMID 8812239 DOI: 10.1093/Toxsci/30.1.93  0.484
1996 Lu YF, Sun G, Wang X, Safe S. Inhibition of prolactin receptor gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 human breast cancer cells. Archives of Biochemistry and Biophysics. 332: 35-40. PMID 8806706 DOI: 10.1006/Abbi.1996.0313  0.643
1996 Hanneman WH, Legare ME, Barhoumi R, Burghardt RC, Safe S, Tiffany-Castiglioni E. Stimulation of calcium uptake in cultured rat hippocampal neurons by 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicology. 112: 19-28. PMID 8792845 DOI: 10.1016/0300-483X(96)03346-X  0.302
1996 Liu H, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on insulin-induced responses in MCF-7 human breast cancer cells. Toxicology and Applied Pharmacology. 138: 242-50. PMID 8658525 DOI: 10.1006/Taap.1996.0122  0.38
1996 Santostefano M, Safe S. Characterization of the molecular and structural properties of the transformed and nuclear aryl hydrocarbon (Ah) receptor complexes by proteolytic digestion. Chemico-Biological Interactions. 100: 221-40. PMID 8653805 DOI: 10.1016/0009-2797(96)03701-5  0.353
1996 Harper N, Steinberg M, Safe S. Immunotoxicity of a reconstituted polynuclear aromatic hydrocarbon mixture in B6C3F1 mice. Toxicology. 109: 31-8. PMID 8619250 DOI: 10.1016/0300-483X(95)03302-V  0.307
1996 Moore M, Ruh M, Steinberg M, Safe S. Isolation and characterization of variant benzo[a]pyrene-resistant T47D human breast-cancer cells. International Journal of Cancer. 66: 117-23. PMID 8608954 DOI: 10.1002/(Sici)1097-0215(19960328)66:1<117::Aid-Ijc20>3.0.Co;2-9  0.474
1996 Wang WL, Thomsen JS, Porter W, Moore M, Safe S. Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells. British Journal of Cancer. 73: 316-22. PMID 8562336 DOI: 10.1038/Bjc.1996.55  0.5
1996 Dickerson R, Keller LH, Safe S. Alkyl polychlorinated dibenzofurans and related compounds as antiestrogens in the female rat uterus: structure-activity studies. Toxicology and Applied Pharmacology. 135: 287-98. PMID 8545839 DOI: 10.1006/Taap.1995.1235  0.316
1996 Safe SH. Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Pharmacology & Therapeutics. 67: 247-81. PMID 7494865 DOI: 10.1016/0163-7258(95)00017-B  0.371
1995 Xiaohong Wang, Thomsen JS, Santostefano M, Rosengren R, Safe S, Perdew GH. Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines European Journal of Pharmacology: Environmental Toxicology And. 293: 191-205. PMID 8666036 DOI: 10.1016/0926-6917(95)00017-8  0.438
1995 Connor K, Safe S, Jefcoate CR, Larsen M. Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats Biochemical Pharmacology. 50: 1913-1920. PMID 8615872 DOI: 10.1016/0006-2952(95)02087-X  0.334
1995 Safe S, Krishnan V. Chlorinated hydrocarbons: estrogens and antiestrogens Toxicology Letters. 82: 731-736. PMID 8597135 DOI: 10.1016/0378-4274(95)03591-5  0.492
1995 Krishnan V, Porter W, Santostefano M, Wang X, Safe S. Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells Molecular and Cellular Biology. 15: 6710-6719. PMID 8524236 DOI: 10.1128/Mcb.15.12.6710  0.487
1995 Wang X, Safe S. Development of an in vitro model for investigating the formation of the nuclear Ah receptor complex in mouse Hepa 1c1c7 cells. Archives of Biochemistry and Biophysics. 315: 285-92. PMID 7986070 DOI: 10.1006/Abbi.1994.1502  0.394
1995 Santosfefano M, Liu H, Wang X, Chaloupka K, Safe S. Effect of ligand structure on formation and DNA binding properties of the transformed rat cytosolic aryl hydrocarbon receptor. Chemical Research in Toxicology. 7: 544-50. PMID 7981419 DOI: 10.1021/Tx00040A010  0.361
1995 Lu YF, Santostefano M, Cunningham BD, Threadgill MD, Safe S. Identification of 3'-methoxy-4'-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells. Archives of Biochemistry and Biophysics. 316: 470-7. PMID 7840652 DOI: 10.1006/Abbi.1995.1062  0.483
1995 Harper N, Wang X, Liu H, Safe S. Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists. Molecular and Cellular Endocrinology. 104: 47-55. PMID 7821706 DOI: 10.1016/0303-7207(94)90050-7  0.48
1995 Safe S, Krishnan V. Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression Archives of Toxicology. Supplement. Archiv Fur Toxikologie. Supplement. 17: 99-115. PMID 7786196 DOI: 10.1007/978-3-642-79451-3_8  0.511
1995 Chaloupka K, Steinberg M, Santostefano M, Rodriguez LV, Goldstein L, Safe S. Induction of Cyp1a-1 and Cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice. Chemico-Biological Interactions. 96: 207-21. PMID 7750161 DOI: 10.1016/0009-2797(94)03586-W  0.318
1995 Merchant M, Safe S. In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by α-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct Biochemical Pharmacology. 50: 663-668. PMID 7669069 DOI: 10.1016/0006-2952(95)00180-8  0.431
1995 Harper N, Steinberg M, Thomsen J, Safe S. Halogenated aromatic hydrocarbon-induced suppression of the plaque-forming cell response in B6C3F1 splenocytes cultured with allogenic mouse serum: Ah receptor structure activity relationships. Toxicology. 99: 199-206. PMID 7610466 DOI: 10.1016/0300-483X(95)03064-M  0.375
1995 Ruh MF, Zacharewski T, Connor K, Howell J, Chen I, Safe S. Naringenin: a weakly estrogenic bioflavonoid that exhibits antiestrogenic activity. Biochemical Pharmacology. 50: 1485-93. PMID 7503800 DOI: 10.1016/0006-2952(95)02061-6  0.417
1995 Willett K, Steinberg M, Thomsen J, Narasimhan TR, Safe S, McDonald S, Beatty K, Kennicutt MC. Exposure of killifish to benzo[a]pyrene: comparative metabolism, DNA adduct formation and aryl hydrocarbon (Ah) receptor agonist activities Comparative Biochemistry and Physiology -- Part B: Biochemistry And. 112: 93-103. DOI: 10.1016/0305-0491(95)00034-6  0.362
1995 HARPER N, CONNOR K, STEINBERG M, SAFE S. Immunosuppressive Activity of Polychiorinated Biphenyl Mixtures and Congeners: Nonadditive (Antagonistic) Interactions Toxicological Sciences. 27: 131-139. DOI: 10.1006/Faat.1995.1116  0.324
1994 Thomsen JS, Wang X, Hines RN, Safe S. Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor. Carcinogenesis. 15: 933-7. PMID 8200098 DOI: 10.1093/Carcin/15.5.933  0.49
1994 Fernandez P, Burghardt R, Smith R, Nodland K, Safe S. High passage T47D human breast cancer cells: altered endocrine and 2,3,7,8-tetrachlorodibenzo-p-dioxin responsiveness. European Journal of Pharmacology. 270: 53-65. PMID 8157081 DOI: 10.1016/0926-6917(94)90080-9  0.457
1994 Liu H, Santostefano M, Safe S. 2-Phenylphenanthridinone and related compounds: aryl hydrocarbon receptor agonists and suicide inactivators of P4501A1. Archives of Biochemistry and Biophysics. 313: 206-14. PMID 8080264 DOI: 10.1006/Abbi.1994.1378  0.418
1994 Lu Y, Wang X, Safe S. Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid in MCF-7 human breast cancer cells. Toxicology and Applied Pharmacology. 127: 1-8. PMID 8048042 DOI: 10.1006/Taap.1994.1132  0.422
1994 Holcomb M, Safe S. Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumor growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cancer Letters. 82: 43-7. PMID 8033067 DOI: 10.1016/0304-3835(94)90144-9  0.35
1994 Chaloupka K, Santostefano M, Goldfarb IS, Liu G, Myers MJ, Tsyrolv IB, Gelboin HV, Krishnan V, Safe S. Aryl hydrocarbon (Ah) receptor-independent induction of Cyp1a2 gene expression by acenaphthylene and related compounds in B6C3F1 mice Carcinogenesis. 15: 2835-2840. PMID 8001243 DOI: 10.1093/Carcin/15.12.2835  0.397
1994 Liu H, Wormke M, Safe SH, Bjeldanes LF. Indolo[3,2-b]carbazole: a dietary-derived factor that exhibits both antiestrogenic and estrogenic activity. Journal of the National Cancer Institute. 86: 1758-65. PMID 7966413 DOI: 10.1093/Jnci/86.23.1758  0.77
1994 Narasimhan TR, Craig A, Arellano L, Harper N, Howie L, Menache M, Birnbaum L, Safe S. Relative sensitivities of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Cyp1a-1 and Cyp1a-2 gene expression and immunotoxicity in female B6C3F1 mice. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 23: 598-607. PMID 7867912 DOI: 10.1006/Faat.1994.1146  0.32
1994 Nakai JS, Winhall MJ, Bunce NJ, Rosengren R, Safe S. Comparative kinetic study of the binding between 2,3,7,8‐tetrachlorodibenzo‐ρ‐dioxin and related ligands with the hepatic Ah receptors from several rodent species Journal of Biochemical Toxicology. 9: 199-209. PMID 7853354 DOI: 10.1002/Jbt.2570090405  0.582
1994 Carvan MJ, SANTOSTEFANO M, SAFE S, BUSBEE D. CHARACTERIZATION OF A BOTTLENOSE DOLPHIN (TURSIOPS TRUNCATUS) KIDNEY EPITHELIAL CELL LINE Marine Mammal Science. 10: 52-69. DOI: 10.1111/J.1748-7692.1994.Tb00389.X  0.385
1993 Randerath E, Randerath K, Reddy R, Narasimhan TR, Wang X, Safe S. Effects of polychlorinated dibenzofurans on compounds in hepatic DNA of female Sprague-Dawley rats: structure dependence and mechanistic considerations. Chemico-Biological Interactions. 88: 175-90. PMID 8403078 DOI: 10.1016/0009-2797(93)90090-L  0.352
1993 Moore M, Narasimhan TR, Steinberg MA, Wang X, Safe S. Potentiation of CYP1A1 gene expression in MCF-7 human breast cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate. Archives of Biochemistry and Biophysics. 305: 483-8. PMID 8396892 DOI: 10.1006/Abbi.1993.1451  0.462
1993 Merchant M, Krishnan V, Safe S. Mechanism of action of α-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells Toxicology and Applied Pharmacology. 120: 179-185. PMID 8390116 DOI: 10.1006/Taap.1993.1101  0.483
1993 Moore M, Narasimhan TR, Wang X, Krishnan V, Safe S, Williams HJ, Scott AI. Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 17 beta-estradiol in MCF-7 human breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 44: 251-61. PMID 8384872 DOI: 10.1016/0960-0760(93)90085-B  0.434
1993 Arellano LO, Wang X, Safe S. Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three human breast cancer cell lines. Carcinogenesis. 14: 219-22. PMID 8382112 DOI: 10.1093/Carcin/14.2.219  0.428
1993 Safe S. Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems. Environmental Health Perspectives. 100: 259-68. PMID 8354174 DOI: 10.1289/Ehp.93100259  0.347
1993 Harper N, Connor K, Safe S. Immunotoxic potencies of polychlorinated biphenyl (PCB), dibenzofuran (PCDF) and dibenzo-p-dioxin (PCDD) congeners in C57BL/6 and DBA/2 mice. Toxicology. 80: 217-27. PMID 8328002 DOI: 10.1016/0300-483X(93)90183-S  0.358
1993 Harper N, Howie L, Connor K, Arellano L, Craig A, Dickerson R, Safe S. Immunosuppressive and monooxygenase induction activities of highly chlorinated diphenyl ether congeners in C57BL/6 and DBA/2 mice. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 20: 496-502. PMID 8314464 DOI: 10.1006/Faat.1993.1060  0.351
1993 Harris M, Zacharewski T, Safe S. Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats--assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs). Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 20: 456-63. PMID 8314461 DOI: 10.1006/Faat.1993.1056  0.335
1993 Harper N, Howie L, Connor K, Dickerson R, Safe S. Immunosuppressive effects of highly chlorinated biphenyls and diphenyl ethers on T-cell dependent and independent antigens in mice. Toxicology. 85: 123-35. PMID 8303708 DOI: 10.1016/0300-483X(93)90037-S  0.361
1993 Wang X, Porter W, Krishnan V, Narasimhan TR, Safe S. Mechanism of 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells Molecular and Cellular Endocrinology. 96: 159-166. PMID 8276131 DOI: 10.1016/0303-7207(93)90106-T  0.444
1993 Chaloupka K, Harper N, Krishnan V, Santostefano M, Rodriguez LV, Safe S. Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists Chemico-Biological Interactions. 89: 141-158. PMID 8269543 DOI: 10.1016/0009-2797(93)90005-J  0.453
1993 Liu H, Santostefano M, Lu Y, Safe S. 6-substituted 3,4-benzocoumarins: a new structural class of inducers and inhibitors of CYP1A1-dependent activity. Archives of Biochemistry and Biophysics. 306: 223-31. PMID 8215408 DOI: 10.1006/Abbi.1993.1504  0.44
1993 Safe S. Development of bioassays and approaches for the risk assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Environmental Health Perspectives. 101: 317-325. PMID 8143638 DOI: 10.1289/Ehp.93101S3317  0.302
1993 Krishnan V, Safe S. Polychlorinated biphenyls (PCB), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: Quantitative structure-activity relationships Toxicology and Applied Pharmacology. 120: 55-61. PMID 7685553 DOI: 10.1006/Taap.1993.1086  0.483
1993 Wang X, Santostefano M, Lu Y, Safe S. A comparison of the mouse versus human aryl hydrocarbon (Ah) receptor complex: effects of proteolysis. Chemico-Biological Interactions. 85: 79-93. PMID 1333892 DOI: 10.1016/0009-2797(92)90054-O  0.352
1992 Krishnan V, Narasimhan T, Safe S. Development of gel staining techniques for detecting the secretion of procathepsin D (52-kDa protein) in MCF-7 human breast cancer cells Analytical Biochemistry. 204: 137-142. PMID 1381155 DOI: 10.1016/0003-2697(92)90152-W  0.374
1992 Chaloupka K, Krishnan V, Safe S. Polynuclear aromatic hydrocarbon carcinogens as antiestrogens m MCF-7 human breast cancer cells: Role of the Ah receptor Carcinogenesis. 13: 2233-2239. PMID 1335374 DOI: 10.1093/Carcin/13.12.2233  0.473
1992 Liu H, Biegel L, Narasimhan TR, Rowlands C, Safe S. Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Molecular and Cellular Endocrinology. 87: 19-28. PMID 1332906 DOI: 10.1016/0303-7207(92)90229-Y  0.422
1992 Merchant M, Morrison V, Santostefano M, Safe S. Mechanism of action of aryl hydrocarbon receptor antagonists: Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression Archives of Biochemistry and Biophysics. 298: 389-394. PMID 1329656 DOI: 10.1016/0003-9861(92)90426-W  0.441
1992 Rosengren R, Safe S, Bunce NJ. Kinetics of the association of several tritiated polychlorinated dibenzo-p-dioxin and dibenzofuran congeners with hepatic cytosolic Ah receptor from the Wistar rat. Chemical Research in Toxicology. 5: 376-82. PMID 1324021 DOI: 10.1021/Tx00027A009  0.596
1992 Fernandez P, Safe S. Growth inhibitory and antimitogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in T47D human breast cancer cells. Toxicology Letters. 61: 185-97. PMID 1322575 DOI: 10.1016/0378-4274(92)90145-A  0.427
1992 Santostefano M, Piskorska-Pliszczynska J, Morrison V, Safe S. Effects of ligand structure on the in vitro transformation of the rat cytosolic aryl hydrocarbon receptor. Archives of Biochemistry and Biophysics. 297: 73-9. PMID 1322114 DOI: 10.1016/0003-9861(92)90642-A  0.353
1992 Wang X, Rosengren R, Morrison V, Santostefano M, Safe S. Characterization of the aryl hydrocarbon receptor in the human C-4II cervical squamous carcinoma cell line. Biochemical Pharmacology. 43: 1635-42. PMID 1314608 DOI: 10.1016/0006-2952(92)90223-6  0.408
1992 Zacharewski T, Harris M, Biegel L, Morrison V, Merchant M, Safe S. 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor. Toxicology and Applied Pharmacology. 113: 311-8. PMID 1313996 DOI: 10.1016/0041-008X(92)90130-K  0.468
1992 Dickerson R, Howie L, Safe S. The effect of 6-nitro-1,3,8-trichlorodibenzofuran as a partial estrogen in the female rat uterus. Toxicology and Applied Pharmacology. 113: 55-63. PMID 1313194 DOI: 10.1016/0041-008X(92)90008-G  0.421
1992 Merchant M, Wang X, Kamps C, Rosengren R, Morrison V, Safe S. Mechanism of benzo[a]pyrene-induced Cyp1a-1 gene expression in mouse Hepa 1c1c7 cells: role of the nuclear 6 s and 4 s proteins. Archives of Biochemistry and Biophysics. 292: 250-7. PMID 1309295 DOI: 10.1016/0003-9861(92)90076-9  0.371
1992 Safe S, Biegel L, Harris M, Narasimhan TR, Lui H, Fernandez P. Inhibition of estrogen- and growth factor-induced proliferation of human breast cancer cell lines by TCDD: characterization and mechanistic studies Chemosphere. 25: 83-86. DOI: 10.1016/0045-6535(92)90485-A  0.463
1992 Bunce NJ, Di Diodato G, Safe S. Photolysis of nitropolychlorodibenzo--dioxins with base as potential methodology for the destruction of polychlorinated dibenzo--dioxins Chemosphere. 24: 433-438. DOI: 10.1016/0045-6535(92)90418-Q  0.506
1992 Wang X, Rosengren R, Morrison V, Safe S. Characterization of the human Ah receptor Chemosphere. 25: 997-1000. DOI: 10.1016/0045-6535(92)90098-C  0.386
1992 Rowlands C, Safe S, Langdon S, Miller WR, Lawrie S. Human ovarian cancer cells: interaction with Tetrachlorodibenzo-p-dioxin (TCDD) Chemosphere. 25: 979-983. DOI: 10.1016/0045-6535(92)90095-9  0.443
1992 Randerath K, Randerath E, Reddy R, Narasimhan T, Wang X, Safe S. Structure-dependent reduction in DNA I-compound adducts by polychlorinated dibenzofurans in female Sprague-Dawley rat liver Chemosphere. 25: 975-978. DOI: 10.1016/0045-6535(92)90094-8  0.326
1992 Merchant M, Morrison V, Safe S. Antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) - induced cyp1A1 gene expression by 6-methyl-1,3,8-trichlorodibenzofuran (MCDF): Mechanistic studies Chemosphere. 25: 967-973. DOI: 10.1016/0045-6535(92)90093-7  0.416
1992 Liu H, Narasimhan TR, Safe S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiproliferative agent in human breast cancer cells: Effects on insulin-induced cell proliferation Chemosphere. 25: 955-958. DOI: 10.1016/0045-6535(92)90091-5  0.377
1992 Liu H, Chinnah A, Kemp M, Safe S. Possible interrelationship between TCDD and interleukin-1 as antiproliferative agents in human breast cancer cells Chemosphere. 25: 951-954. DOI: 10.1016/0045-6535(92)90090-E  0.427
1992 Krishnan V, Narisimhan TR, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as an antiestrogen in MCF-7 human breast cancer cells Chemosphere. 25: 947-950. DOI: 10.1016/0045-6535(92)90089-A  0.34
1991 Astroff B, Rowlands C, Dickerson R, Safe S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17 beta-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression. Molecular and Cellular Endocrinology. 72: 247-52. PMID 2289633 DOI: 10.1016/0303-7207(90)90149-3  0.416
1991 Biegel L, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cell growth and the secretion of the estrogen-induced 34-, 52- and 160-kDa proteins in human breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 37: 725-32. PMID 2278856 DOI: 10.1016/0960-0760(90)90357-Q  0.415
1991 Astroff B, Safe S. 6-Alkyl-1,3,8-trichlorodibenzofurans as antiestrogens in female Sprague-Dawley rats. Toxicology. 69: 187-97. PMID 1949047 DOI: 10.1016/0300-483X(91)90230-X  0.392
1991 Astroff B, Eldridge B, Safe S. Inhibition of the 17 beta-estradiol-induced and constitutive expression of the cellular protooncogene c-fos by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the female rat uterus. Toxicology Letters. 56: 305-15. PMID 1903567 DOI: 10.1016/0378-4274(91)90159-4  0.334
1991 Piskorska-Pliszczynska J, Astroff B, Zacharewski T, Harris M, Rosengren R, Morrison V, Safe L, Safe S. Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes. Archives of Biochemistry and Biophysics. 284: 193-200. PMID 1846513 DOI: 10.1016/0003-9861(91)90283-O  0.374
1991 Safe S, Astroff B, Harris M, Zacharewski T, Dickerson R, Romkes M, Biegel L. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action. Pharmacology & Toxicology. 69: 400-9. PMID 1766914 DOI: 10.1111/J.1600-0773.1991.Tb01321.X  0.509
1991 Piskorska-Pliszczynska J, Morrison V, Zacharewski T, Safe S. DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells. Archives of Biochemistry and Biophysics. 290: 362-8. PMID 1656877 DOI: 10.1016/0003-9861(91)90552-T  0.386
1991 Davis D, Safe S. Halogenated aryl hydrocarbon-induced suppression of the in vitro plaque-forming cell response to sheep red blood cells is not dependent on the Ah receptor. Immunopharmacology. 21: 183-90. PMID 1655676 DOI: 10.1016/0162-3109(91)90023-R  0.412
1991 Wang X, Narasimhan TR, Morrison V, Safe S. In situ and in vitro photoaffinity labeling of the nuclear aryl hydrocarbon receptor from transformed rodent and human cell lines. Archives of Biochemistry and Biophysics. 287: 186-94. PMID 1654803 DOI: 10.1016/0003-9861(91)90405-8  0.385
1991 Zacharewski T, Harris M, Safe S. Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse Hepa 1c1c7 cells. Biochemical Pharmacology. 41: 1931-9. PMID 1645554 DOI: 10.1016/0006-2952(91)90133-P  0.429
1990 Kelley M, Womack J, Safe S. Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins. Biochemical Pharmacology. 39: 1991-8. PMID 2353939 DOI: 10.1016/0006-2952(90)90620-Z  0.316
1990 Harris M, Zacharewski T, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells. Cancer Research. 50: 3579-84. PMID 2340506  0.333
1990 Harris M, Zacharewski T, Piskorska-Pliszczynska J, Rosengren R, Safe S. Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: mechanistic studies. Toxicology and Applied Pharmacology. 105: 243-53. PMID 2219118 DOI: 10.1016/0041-008X(90)90186-X  0.382
1990 Merchant M, Arellano L, Safe S. The mechanism of action of alpha-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression. Archives of Biochemistry and Biophysics. 281: 84-9. PMID 2166479 DOI: 10.1016/0003-9861(90)90416-V  0.358
1990 Davis D, Safe S. Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: structure-activity relationships as Ah receptor agonists and partial antagonists. Toxicology. 63: 97-111. PMID 2166363 DOI: 10.1016/0300-483X(90)90072-O  0.323
1990 Randerath K, Putman KL, Randerath E, Zacharewski T, Harris M, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of Sprague-Dawley rats: sex-specific effects and structure-activity relationships. Toxicology and Applied Pharmacology. 103: 271-80. PMID 2158676 DOI: 10.1016/0041-008X(90)90229-N  0.311
1990 Astroff B, Safe S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiestrogen: effect on rat uterine peroxidase activity. Biochemical Pharmacology. 39: 485-8. PMID 2154986 DOI: 10.1016/0006-2952(90)90054-O  0.397
1990 Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Critical Reviews in Toxicology. 21: 51-88. PMID 2124811 DOI: 10.3109/10408449009089873  0.318
1990 Howie L, Dickerson R, Davis D, Safe S. Immunosuppressive and monooxygenase induction activities of polychlorinated diphenyl ether congeners in C57BL/6N mice: quantitative structure-activity relationships. Toxicology and Applied Pharmacology. 105: 254-63. PMID 2120796 DOI: 10.1016/0041-008X(90)90187-Y  0.363
1990 Bunce NJ, Landers JP, Schneider UA, Safe SH, Zacharewski TR. Chlorinated trans stilbenes: Competitive binding to the ah receptor, induction of cytochrome p-450 monooxygenase activity and partial 2, 3, 7, 8-TCDD antagonism Toxicological & Environmental Chemistry. 28: 217-229. DOI: 10.1080/02772249009357605  0.759
1990 Bunce NJ, Landers JP, Nakai JS, Winhall MJ, Safe SH. In vitro thermal inactivation of hepatic Ah receptors from several mammalian species Toxicology in Vitro. 4: 87-92. DOI: 10.1016/0887-2333(90)90028-R  0.656
1990 DICKERSON R, HOWIE L, DAVIS D, SAFE S. The Structure-Dependent Effects of Heptachlorodibenzofuran Isomers in Male C57BL/6 Mice: Immunotoxicity and onooxygenase Enzyme Induction Toxicological Sciences. 15: 298-307. DOI: 10.1016/0272-0590(90)90056-P  0.316
1990 Landers JP, Safe SH, Bunce NJ. [3H]-Tetrachlorodibenzo-p-dioxin: An efficient photoaffinity label for the Ah receptor Chemosphere. 20: 1241-1248. DOI: 10.1016/0045-6535(90)90252-O  0.631
1989 Randerath K, Putman KL, Randerath E, Mason G, Kelley M, Safe S. Organ-specific effects of long term feeding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 1,2,3,7,8-pentachlorodibenzo-p-dioxin on I-compounds in hepatic and renal DNA of female Sprague-Dawley rats. Carcinogenesis. 9: 2285-9. PMID 3191574 DOI: 10.1093/Carcin/9.12.2285  0.301
1989 Bannister R, Biegel L, Davis D, Astroff B, Safe S. 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice. Toxicology. 54: 139-50. PMID 2922766 DOI: 10.1016/0300-483X(89)90040-1  0.362
1989 Piskorska-Pliszczynska J, Safe S. Radioligand-dependent differences in the molecular properties of the mouse and rat hepatic aryl hydrocarbon receptor complexes. Archives of Biochemistry and Biophysics. 267: 372-83. PMID 2848453 DOI: 10.1016/0003-9861(88)90043-4  0.307
1989 Safe S, Mason G, Sawyer T, Zacharewski T, Harris M, Yao C, Keys B, Farrell K, Holcomb M, Davis D. Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review. Toxicology and Industrial Health. 5: 757-75. PMID 2683222 DOI: 10.1177/074823378900500513  0.343
1989 Astroff B, Safe S. 6-substituted-1,3,8-trichlorodibenzofurans as 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists in the rat: structure activity relationships. Toxicology. 59: 285-96. PMID 2631297 DOI: 10.1016/0300-483X(89)90198-4  0.39
1989 Biegel L, Harris M, Davis D, Rosengren R, Safe L, Safe S. 2,2′,4,4′,5,5′-Hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL6J mice Toxicology and Applied Pharmacology. 97: 561-571. PMID 2558429 DOI: 10.1016/0041-008X(89)90261-5  0.409
1989 Landers JP, Piskorska-Pliszczynska J, Zacharewski T, Bunce NJ, Safe S. Photoaffinity labeling of the nuclear Ah receptor from mouse Hepa 1c1c7 cells using 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin Journal of Biological Chemistry. 264: 18463-18471. PMID 2553709  0.492
1989 Zacharewski T, Harris M, Safe S. Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners. Archives of Biochemistry and Biophysics. 272: 344-55. PMID 2546497 DOI: 10.1016/0003-9861(89)90228-2  0.4
1989 Harris M, Piskorska-Pliszczynska J, Zacharewski T, Romkes M, Safe S. Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor. Cancer Research. 49: 4531-5. PMID 2545344  0.335
1989 Davis D, Safe S. Dose-response immunotoxicities of commercial polychlorinated biphenyls (PCBs) and their interaction with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology Letters. 48: 35-43. PMID 2501913 DOI: 10.1016/0378-4274(89)90183-5  0.306
1989 Safe S. Polychlorinated biphenyls (PCBs): mutagenicity and carcinogenicity. Mutation Research. 220: 31-47. PMID 2492077 DOI: 10.1016/0165-1110(89)90007-9  0.376
1989 Li SMA, Denomme MA, Leece B, Towner R, Safe* S. Hexachlorobenzene: Biochemical effects and synergistic toxic interactions with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin Toxicological & Environmental Chemistry. 22: 215-227. DOI: 10.1080/02772248909357440  0.308
1989 Wærn F, Hanberg A, Manzoor E, Safe S, Ahlborg U. Interaction of 6-methyl-1,3,8-trichlorodibenzofuran with tcdd-induced vitamin A reduction Chemosphere. 19: 1005-1008. DOI: 10.1016/0045-6535(89)90449-9  0.325
1989 Piskorska-Pliszczynska J, Safe S. Radioligand-dependent properties of the Ah receptor from rat and mouse hepatic cytosol Chemosphere. 19: 963-968. DOI: 10.1016/0045-6535(89)90441-4  0.31
1989 Landers JP, Bunce NJ, Nakai JS, Winhall MJ, Safe SH. Interspecies differences in in vitro thermal inactivation of unliganded hepatic Ah receptor Chemosphere. 19: 959-962. DOI: 10.1016/0045-6535(89)90440-2  0.643
1989 Biegel L, Howie L, Safe S. Polychlorinated biphenyl (PCB) congeners as 2,3,7,8-TCDD antagonists: Teratogenicity studies Chemosphere. 19: 955-958. DOI: 10.1016/0045-6535(89)90439-6  0.324
1989 Bannister R, Davis D, Biegel L, Astroff B, Safe S. 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-TCDD antagonist in C57BL/6 mice Chemosphere. 19: 949-953. DOI: 10.1016/0045-6535(89)90438-4  0.324
1989 Safe S, Davis D, Romkes M, Yao C, Keyes B, Piskorska-Pliszczynska J, Farrell K, Mason G, Denomme M, Safe L, Zmudzka B, Holcomb M. Development and validation of in vitro bioassays for 2,3,7,8-TCDD equivalents Chemosphere. 19: 853-860. DOI: 10.1016/0045-6535(89)90421-9  0.326
1989 Astroff B, Romkes M, Safe S. Mechanism of action of 2,3,7,8-tcdd and 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) as antiestrogens in the female rat Chemosphere. 19: 785-788. DOI: 10.1016/0045-6535(89)90409-8  0.416
1989 Harris M, Zacharewski T, Astroff B, Kamps C, Safe S. Characterization of 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-TCDD antagonist in male rats: induction of monooxygenases Chemosphere. 19: 769-772. DOI: 10.1016/0045-6535(89)90406-2  0.363
1989 Safe S. Risk assessment of PCDDs and PCDFs based on in vitro and in vivo bioassays Chemosphere. 19: 609-613. DOI: 10.1016/0045-6535(89)90379-2  0.378
1989 Safe S, Zacharewski T, Safe L, Harris M, Yao C, Holcomb M. Validation of the AHH indoction bioassay for the determination of 2,3,7,8-TCDD toxic equivalents Chemosphere. 18: 941-946. DOI: 10.1016/0045-6535(89)90221-X  0.323
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