Alan Jay Grodzinsky - Publications

Massachusetts Institute of Technology, Cambridge, MA, United States 

286 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zhang CH, Gao Y, Jadhav U, Hung HH, Holton KM, Grodzinsky AJ, Shivdasani RA, Lassar AB. Creb5 establishes the competence for Prg4 expression in articular cartilage. Communications Biology. 4: 332. PMID 33712729 DOI: 10.1038/s42003-021-01857-0  1
2020 Black RM, Wang Y, Struglics A, Lorenzo P, Tillgren V, Rydén M, Grodzinsky AJ, Önnerfjord P. Proteomic analysis reveals dexamethasone rescues matrix breakdown but not anabolic dysregulation in a cartilage injury model. Osteoarthritis and Cartilage Open. 2. PMID 34322675 DOI: 10.1016/j.ocarto.2020.100099  1
2020 Eskelinen ASA, Tanska P, Florea C, Orozco GA, Julkunen P, Grodzinsky AJ, Korhonen RK. Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus. Plos Computational Biology. 16: e1007998. PMID 32584809 DOI: 10.1371/Journal.Pcbi.1007998  0.01
2019 Black R, Grodzinsky AJ. Dexamethasone: chondroprotective corticosteroid or catabolic killer? European Cells & Materials. 38: 246-263. PMID 31755076 DOI: 10.22203/Ecm.V038A17  0.08
2019 Connizzo BK, Grodzinsky AJ. Lose-Dose Administration of Dexamethasone is Beneficial in Preventing Secondary Tendon Damage in a Stress-Deprived Joint Injury Explant Model. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 31441099 DOI: 10.1002/Jor.24451  1
2019 Connizzo BK, Piet JM, Shefelbine SJ, Grodzinsky AJ. Age-associated changes in the response of tendon explants to stress deprivation is sex-dependent. Connective Tissue Research. 1-15. PMID 31411079 DOI: 10.1080/03008207.2019.1648444  1
2019 Zanotto G, Liebesny P, Barrett M, Zlotnick H, Grodzinsky A, Frisbie D. Trypsin pre-treatment combined with growth-factor functionalized self-assembling peptide hydrogel improves cartilage repair in rabbit model. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 31318103 DOI: 10.1002/Jor.24414  1
2019 Wallace IJ, Bendele AM, Riew G, Frank EH, Hung HH, Holowka NB, Bolze AS, Venable EM, Yegian A, Dingwall HL, Carmody RN, Grodzinsky AJ, Lieberman DE. Physical inactivity and knee osteoarthritis in guinea pigs. Osteoarthritis and Cartilage. PMID 31302235 DOI: 10.1016/J.Joca.2019.07.005  1
2019 Liebesny PH, Mroszczyk KA, Zlotnick HM, Hung HH, Frank E, Kurz B, Zanotto GM, Frisbie DD, Grodzinsky AJ. Enzyme pretreatment plus locally delivered HB-IGF-1 stimulates integrative cartilage repair in vitro. Tissue Engineering. Part A. PMID 31237484 DOI: 10.1089/Ten.Tea.2019.0013  1
2019 Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, ... ... Grodzinsky AJ, et al. Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nature Biomedical Engineering. 3: 230-245. PMID 30948807 DOI: 10.1038/S41551-018-0334-7  1
2019 Sellon JB, Azadi M, Oftadeh R, Nia HT, Ghaffari R, Grodzinsky AJ, Freeman DM. Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections. Physical Review Letters. 122: 028101. PMID 30720330 DOI: 10.1103/Physrevlett.122.028101  1
2019 Frank E, Hung H-, Krishnan Y, Senter B, Bodick N, Grodzinsky A. Dose-dependent chondroprotective effects of triamcinolone acetonide on inflamed and injured cartilage using an in vitro model Osteoarthritis and Cartilage. 27. DOI: 10.1016/J.Joca.2019.02.265  1
2018 Geiger BC, Wang S, Padera RF, Grodzinsky AJ, Hammond PT. Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis. Science Translational Medicine. 10. PMID 30487252 DOI: 10.1126/Scitranslmed.Aat8800  1
2018 Orozco GA, Tanska P, Florea C, Grodzinsky AJ, Korhonen RK. A novel mechanobiological model can predict how physiologically relevant dynamic loading causes proteoglycan loss in mechanically injured articular cartilage. Scientific Reports. 8: 15599. PMID 30348953 DOI: 10.1038/S41598-018-33759-3  0.01
2018 Krishnan Y, Rees HA, Rossitto CP, Kim SE, Hung HK, Frank EH, Olsen BD, Liu DR, Hammond PT, Grodzinsky AJ. Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues. Biomaterials. 183: 218-233. PMID 30173104 DOI: 10.1016/J.Biomaterials.2018.08.050  1
2018 Krishnan Y, Grodzinsky AJ. Cartilage diseases. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 29803938 DOI: 10.1016/j.matbio.2018.05.005  1
2018 Ravindra KC, Ahrens CC, Wang Y, Ramseier JY, Wishnok JS, Griffith LG, Grodzinsky AJ, Tannenbaum SR. Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis. The Journal of Biological Chemistry. PMID 29794029 DOI: 10.1074/Jbc.M117.818542  1
2018 Kim CW, Hosseini A, Lin L, Wang Y, Torriani M, Gill T, Grodzinsky AJ, Li G. Quantitative analysis of T2 relaxation times of the patellofemoral joint cartilage 3 years after anterior cruciate ligament reconstruction. Journal of Orthopaedic Translation. 12: 85-92. PMID 29662782 DOI: 10.1016/J.Jot.2017.06.002  1
2018 Connizzo BK, Grodzinsky AJ. Release of Pro-Inflammatory Cytokines from Muscle and Bone Causes Tenocyte Death in a Novel Rotator Cuff In Vitro Explant Culture Model. Connective Tissue Research. PMID 29447021 DOI: 10.1080/03008207.2018.1439486  1
2018 Oftadeh R, Connizzo BK, Nia HT, Ortiz C, Grodzinsky AJ. Biological connective tissues exhibit viscoelastic and poroelastic behavior at different frequency regimes: application to tendon and skin biophysics. Acta Biomaterialia. PMID 29425716 DOI: 10.1016/J.Actbio.2018.01.041  1
2018 Connizzo BK, Grodzinsky AJ. Multiscale Poroviscoelastic Compressive Properties of Mouse Supraspinatus Tendons Are Altered in Young and Aged Mice. Journal of Biomechanical Engineering. 140. PMID 29238818 DOI: 10.1115/1.4038745  1
2018 Behrendt P, Feldheim M, Preusse-Prange A, Weitkamp JT, Haake M, Eglin D, Rolauffs B, Fay J, Seekamp A, Grodzinsky AJ, Kurz B. Chondrogenic potential of IL-10 in mechanically injured cartilage and cellularized collagen ACI grafts. Osteoarthritis and Cartilage. 26: 264-275. PMID 29169959 DOI: 10.1016/J.Joca.2017.11.007  1
2018 Rothdiener M, Uynuk-Ool T, Südkamp N, Aurich M, Grodzinsky AJ, Kurz B, Rolauffs B. Human osteoarthritic chondrons outnumber patient- and joint-matched chondrocytes in hydrogel culture-Future application in autologous cell-based OA cartilage repair? Journal of Tissue Engineering and Regenerative Medicine. 12: e1206-e1220. PMID 28714570 DOI: 10.1002/Term.2516  1
2018 Oftadeh R, Heilig J, Zaucke F, Niehoff A, Grodzinsky AJ. High-bandwidth atomic force microscopy (AFM) based rheology of murine cartilage reveals degeneration of collagen IX knock out mice cartilage compared to wild type cartilage in terms of equilibrium and dynamic fluid-solid interaction properties Osteoarthritis and Cartilage. 26. DOI: 10.1016/J.Joca.2018.02.132  1
2017 Han B, Nia HT, Wang C, Chandrasekaran P, Li Q, Chery DR, Li H, Grodzinsky AJ, Han L. AFM-Nanomechanical Test: An Interdisciplinary Tool That Links the Understanding of Cartilage and Meniscus Biomechanics, Osteoarthritis Degeneration, and Tissue Engineering. Acs Biomaterials Science & Engineering. 3: 2033-2049. PMID 31423463 DOI: 10.1021/Acsbiomaterials.7B00307  1
2017 Bajpayee AG, De la Vega RE, Scheu M, Varady NH, Yannatos IA, Brown LA, Krishnan Y, Fitzsimons TJ, Bhattacharya P, Frank EH, Grodzinsky AJ, Porter RM. Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis. European Cells & Materials. 34: 341-364. PMID 29205258 DOI: 10.22203/Ecm.V034A21  1
2017 Hu J, Jafari S, Han Y, Grodzinsky AJ, Cai S, Guo M. Size- and speed-dependent mechanical behavior in living mammalian cytoplasm. Proceedings of the National Academy of Sciences of the United States of America. PMID 28827333 DOI: 10.1073/Pnas.1702488114  0.32
2017 Swärd P, Wang Y, Hansson M, Lohmander LS, Grodzinsky AJ, Struglics A. Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity. Arthritis Research & Therapy. 19: 157. PMID 28679445 DOI: 10.1186/S13075-017-1318-9  1
2017 Bricca A, Juhl CB, Grodzinsky AJ, Roos EM. Impact of a daily exercise dose on knee joint cartilage - a systematic review and meta-analysis of randomized controlled trials in healthy animals. Osteoarthritis and Cartilage. 25: 1223-1237. PMID 28323138 DOI: 10.1016/J.Joca.2017.03.009  0.01
2017 Connizzo BK, Grodzinsky AJ. Tendon exhibits complex poroelastic behavior at the nanoscale as revealed by high-frequency AFM-based rheology. Journal of Biomechanics. 54: 11-18. PMID 28233551 DOI: 10.1016/J.Jbiomech.2017.01.029  1
2017 Bajpayee AG, Grodzinsky AJ. Cartilage-targeting drug delivery: can electrostatic interactions help? Nature Reviews. Rheumatology. 13: 183-193. PMID 28202920 DOI: 10.1038/Nrrheum.2016.210  1
2017 Rahbari NN, Kedrin D, Incio J, Liu H, Ho WT, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin J, Huang Y, Maimon N, Reissfelder C, ... ... Grodzinsky AJ, et al. Abstract PR06: VEGF-targeted therapy induces extracellular matrix remodeling and increases mechanical barriers to therapy in colorectal cancer liver metastases Cancer Research. 77. DOI: 10.1158/1538-7445.Epso16-Pr06  1
2017 Nia H, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan V, Jung K, Martin J, Askoxylakis V, Padera T, Fukumura D, Boucher Y, Hornicek F, ... Grodzinsky A, et al. Abstract 3987: Solid stress and elastic energy as measures of tumor mechanopathology Cancer Research. 77: 3987-3987. DOI: 10.1158/1538-7445.Am2017-3987  1
2016 Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, ... Grodzinsky AJ, et al. Solid stress and elastic energy as measures of tumour mechanopathology. Nature Biomedical Engineering. 1. PMID 28966873 DOI: 10.1038/S41551-016-0004  1
2016 Shah NJ, Geiger BC, Quadir MA, Hyder MN, Krishnan Y, Grodzinsky AJ, Hammond PT. Synthetic nanoscale electrostatic particles as growth factor carriers for cartilage repair. Bioengineering & Translational Medicine. 1: 347-356. PMID 28584879 DOI: 10.1002/btm2.10043  1
2016 Wang Y, Li Y, Khabut A, Chubinskaya S, Grodzinsky AJ, Önnerfjord P. Quantitative proteomics analysis of cartilage response to mechanical injury and cytokine treatment. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 27988350 DOI: 10.1016/J.Matbio.2016.12.004  1
2016 Kar S, Smith DW, Gardiner BS, Grodzinsky AJ. Systems Based Study of the Therapeutic Potential of Small Charged Molecules for the Inhibition of IL-1 Mediated Cartilage Degradation. Plos One. 11: e0168047. PMID 27977731 DOI: 10.1371/Journal.Pone.0168047  1
2016 Hanifi A, Palukuru U, McGoverin C, Shockley M, Frank E, Grodzinsky A, Spencer RG, Pleshko N. Near infrared spectroscopic assessment of developing engineered tissues: correlations with compositional and mechanical properties. The Analyst. PMID 27975090 DOI: 10.1039/C6An02167K  1
2016 Hajjarian Z, Nia HT, Ahn S, Grodzinsky AJ, Jain RK, Nadkarni SK. Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds. Scientific Reports. 6: 37949. PMID 27905494 DOI: 10.1038/Srep37949  1
2016 Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, ... ... Grodzinsky AJ, et al. Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Science Translational Medicine. 8: 360ra135. PMID 27733559 DOI: 10.1126/Scitranslmed.Aaf5219  1
2016 Behrendt P, Preusse-Prange A, Klüter T, Haake M, Rolauffs B, Grodzinsky AJ, Lippross S, Kurz B. IL-10 Reduces Apoptosis And Extracellular Matrix Degradation After Injurious Compression Of Mature Articular Cartilage. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. PMID 27349464 DOI: 10.1016/J.Joca.2016.06.016  1
2016 Liebesny PH, Byun S, Hung HH, Pancoast JR, Mroszczyk KA, Young W, Lee RT, Frisbie DD, Kisiday J, Grodzinsky AJ. Growth factor-mediated migration of bone marrow progenitor cells for accelerated scaffold recruitment. Tissue Engineering. Part A. PMID 27268956 DOI: 10.1089/Ten.Tea.2015.0524  1
2016 Grodzinsky AJ, Wang Y, Kakar S, Vrahas MS, Evans CH. Intra-articular dexamethasone to inhibit the development of post-traumatic osteoarthritis. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 27176565 DOI: 10.1002/Jor.23295  1
2016 Azadi M, Nia HT, Gauci SJ, Ortiz C, Fosang AJ, Grodzinsky AJ. Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse. Journal of Biomechanics. PMID 27086115 DOI: 10.1016/J.Jbiomech.2016.03.055  1
2016 Felka T, Rothdiener M, Bast S, Uynuk-Ool T, Zouhair S, Ochs BG, De Zwart P, Stoeckle U, Aicher WK, Hart ML, Shiozawa T, Grodzinsky AJ, Schenke-Layland K, Venkatesan JK, Cucchiarini M, et al. Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. PMID 26879798 DOI: 10.1016/J.Joca.2016.02.001  1
2016 Kar S, Smith DW, Gardiner BS, Li Y, Wang Y, Grodzinsky AJ. Modeling IL-1 induced degradation of articular cartilage. Archives of Biochemistry and Biophysics. PMID 26874194 DOI: 10.1016/J.Abb.2016.02.008  1
2016 Kashany ZH, Ahn S, Nia HT, Tshikudi DM, Grodzinsky A, Jain RK, Nadkarni SK. Laser speckle micro rheology for micro-mechanical mapping of bio-materials(Conference Presentation) Proceedings of Spie. 9707: 970702. DOI: 10.1117/12.2213761  1
2016 Grodzinsky AJ. Novel approaches to delivery of IA therapy in OA Osteoarthritis and Cartilage. 24. DOI: 10.1016/J.Joca.2016.01.024  0.01
2015 Scarcelli G, Polacheck WJ, Nia HT, Patel K, Grodzinsky AJ, Kamm RD, Yun SH. Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy. Nature Methods. PMID 26436482 DOI: 10.1038/Nmeth.3616  1
2015 Bajpayee AG, Quadir MA, Hammond PT, Grodzinsky AJ. Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. PMID 26211608 DOI: 10.1016/J.Joca.2015.07.010  1
2015 Gardiner BS, Woodhouse FG, Besier TF, Grodzinsky AJ, Lloyd DG, Zhang L, Smith DW. Predicting Knee Osteoarthritis. Annals of Biomedical Engineering. PMID 26206679 DOI: 10.1007/S10439-015-1393-5  1
2015 Bae JH, Hosseini A, Wang Y, Torriani M, Gill TJ, Grodzinsky AJ, Li G. Articular cartilage of the knee 3 years after ACL reconstruction. Acta Orthopaedica. 1-6. PMID 25854533 DOI: 10.3109/17453674.2015.1039426  1
2015 Li Q, Doyran B, Gamer LW, Lu XL, Qin L, Ortiz C, Grodzinsky AJ, Rosen V, Han L. Biomechanical properties of murine meniscus surface via AFM-based nanoindentation. Journal of Biomechanics. 48: 1364-70. PMID 25817332 DOI: 10.1016/J.Jbiomech.2015.02.064  1
2015 Nia HT, Han L, Bozchalooi IS, Roughley P, Youcef-Toumi K, Grodzinsky AJ, Ortiz C. Aggrecan nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties. Acs Nano. 9: 2614-25. PMID 25758717 DOI: 10.1021/Nn5062707  1
2015 Bajpayee AG, Scheu M, Grodzinsky AJ, Porter RM. A rabbit model demonstrates the influence of cartilage thickness on intra-articular drug delivery and retention within cartilage. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 33: 660-7. PMID 25627105 DOI: 10.1002/Jor.22841  1
2015 Lee B, Han L, Frank EH, Grodzinsky AJ, Ortiz C. Dynamic nanomechanics of individual bone marrow stromal cells and cell-matrix composites during chondrogenic differentiation. Journal of Biomechanics. 48: 171-5. PMID 25468666 DOI: 10.1016/J.Jbiomech.2014.11.005  1
2015 Li Y, Wang Y, Chubinskaya S, Schoeberl B, Florine E, Kopesky P, Grodzinsky AJ. Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis. Osteoarthritis and Cartilage. 23: 266-74. PMID 25450855 DOI: 10.1016/J.Joca.2014.11.006  1
2015 Nia HT, Gauci SJ, Azadi M, Hung HH, Frank E, Fosang AJ, Ortiz C, Grodzinsky AJ. High-bandwidth AFM-based rheology is a sensitive indicator of early cartilage aggrecan degradation relevant to mouse models of osteoarthritis. Journal of Biomechanics. 48: 162-5. PMID 25435386 DOI: 10.1016/J.Jbiomech.2014.11.012  1
2015 Zhang L, Miramini S, Smith DW, Gardiner BS, Grodzinsky AJ. Time evolution of deformation in a human cartilage under cyclic loading. Annals of Biomedical Engineering. 43: 1166-77. PMID 25331101 DOI: 10.1007/S10439-014-1164-8  1
2015 Nia HT, Ortiz C, Grodzinsky A. Aggrecan: approaches to study biophysical and biomechanical properties. Methods in Molecular Biology (Clifton, N.J.). 1229: 221-37. PMID 25325957 DOI: 10.1007/978-1-4939-1714-3_20  1
2015 Florine EM, Miller RE, Liebesny PH, Mroszczyk KA, Lee RT, Patwari P, Grodzinsky AJ. Delivering heparin-binding insulin-like growth factor 1 with self-assembling peptide hydrogels. Tissue Engineering. Part A. 21: 637-46. PMID 25231349 DOI: 10.1089/Ten.Tea.2013.0679  1
2015 Bajpayee AG, Scheu A, Vega RD, Varady NH, Yannatos IA, Porter RM, Grodzinsky AJ. Intra-cartilage delivery of dexamethasone from avidin, a cationic drug carrier, attenuates injury induced catabolic effects in knee joints of mature rabbits in vivo Osteoarthritis and Cartilage. 23. DOI: 10.1016/J.Joca.2015.02.877  1
2015 Gardiner BS, Woodhouse FG, Besier TF, Grodzinsky AJ, Lloyd DG, Zhang L, Smith DW. Predicting Knee Osteoarthritis Annals of Biomedical Engineering. DOI: 10.1007/s10439-015-1393-5  1
2014 Miller RE, Grodzinsky AJ, Barrett MF, Hung HH, Frank EH, Werpy NM, McIlwraith CW, Frisbie DD. Effects of the combination of microfracture and self-assembling Peptide filling on the repair of a clinically relevant trochlear defect in an equine model. The Journal of Bone and Joint Surgery. American Volume. 96: 1601-9. PMID 25274785 DOI: 10.2106/Jbjs.M.01408  1
2014 Åhrman E, Lorenzo P, Holmgren K, Grodzinsky AJ, Dahlberg LE, Saxne T, Heinegård D, Önnerfjord P. Novel cartilage oligomeric matrix protein (COMP) neoepitopes identified in synovial fluids from patients with joint diseases using affinity chromatography and mass spectrometry. The Journal of Biological Chemistry. 289: 20908-16. PMID 24917676 DOI: 10.1074/Jbc.M114.554683  1
2014 Batista MA, Nia HT, Önnerfjord P, Cox KA, Ortiz C, Grodzinsky AJ, Heinegård D, Han L. Nanomechanical phenotype of chondroadherin-null murine articular cartilage. Matrix Biology : Journal of the International Society For Matrix Biology. 38: 84-90. PMID 24892719 DOI: 10.1016/J.Matbio.2014.05.008  1
2014 Bajpayee AG, Scheu M, Grodzinsky AJ, Porter RM. Electrostatic interactions enable rapid penetration, enhanced uptake and retention of intra-articular injected avidin in rat knee joints. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 32: 1044-51. PMID 24753019 DOI: 10.1016/J.Joca.2014.02.899  1
2014 Irrechukwu ON, Thaer SV, Frank EH, Lin PC, Reiter DA, Grodzinsky AJ, Spencer RG. Prediction of cartilage compressive modulus using multiexponential analysis of T(2) relaxation data and support vector regression. Nmr in Biomedicine. 27: 468-77. PMID 24519878 DOI: 10.1002/Nbm.3083  1
2014 Rojas FP, Batista MA, Lindburg CA, Dean D, Grodzinsky AJ, Ortiz C, Han L. Molecular adhesion between cartilage extracellular matrix macromolecules. Biomacromolecules. 15: 772-80. PMID 24491174 DOI: 10.1021/Bm401611B  1
2014 Ogawa H, Kozhemyakina E, Hung HH, Grodzinsky AJ, Lassar AB. Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways. Genes & Development. 28: 127-39. PMID 24449269 DOI: 10.1101/Gad.231969.113  1
2014 Bajpayee AG, Wong CR, Bawendi MG, Frank EH, Grodzinsky AJ. Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis. Biomaterials. 35: 538-49. PMID 24120044 DOI: 10.1016/J.Biomaterials.2013.09.091  1
2014 Wagner T, Eden U, Rushmore J, Russo CJ, Dipietro L, Fregni F, Simon S, Rotman S, Pitskel NB, Ramos-Estebanez C, Pascual-Leone A, Grodzinsky AJ, Zahn M, Valero-Cabré A. Impact of brain tissue filtering on neurostimulation fields: a modeling study. Neuroimage. 85: 1048-57. PMID 23850466 DOI: 10.1016/J.Neuroimage.2013.06.079  1
2014 Kopesky PW, Byun S, Vanderploeg EJ, Kisiday JD, Frisbie DD, Grodzinsky AJ. Sustained delivery of bioactive TGF-β1 from self-assembling peptide hydrogels induces chondrogenesis of encapsulated bone marrow stromal cells. Journal of Biomedical Materials Research. Part A. 102: 1275-85. PMID 23650117 DOI: 10.1002/Jbm.A.34789  1
2014 Hansson M, Swärd P, Wang Y, Lohmander LS, Grodzinsky A, Struglics A. Does joint capsule and synovial fluid contain proteases capable of degrading aggrecan Osteoarthritis and Cartilage. 22: 136-137. DOI: 10.1016/J.Joca.2014.02.251  1
2013 Florine EM, Miller RE, Porter RM, Evans CH, Kurz B, Grodzinsky AJ. Effects of Dexamethasone on Mesenchymal Stromal Cell Chondrogenesis and Aggrecanase Activity: Comparison of Agarose and Self-Assembling Peptide Scaffolds. Cartilage. 4: 63-74. PMID 24533173 DOI: 10.1177/1947603512455196  1
2013 Byun S, Sinskey YL, Lu YC, Frank EH, Grodzinsky AJ. Transport and binding of tumor necrosis factor-α in articular cartilage depend on its quaternary structure. Archives of Biochemistry and Biophysics. 540: 1-8. PMID 24135706 DOI: 10.1016/J.Abb.2013.10.003  1
2013 Li Y, Frank EH, Wang Y, Chubinskaya S, Huang HH, Grodzinsky AJ. Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-α and interleukin-6, but accentuates degradation above a strain threshold. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 21: 1933-41. PMID 24007885 DOI: 10.1016/J.Joca.2013.08.021  1
2013 Imgenberg J, Rolauffs B, Grodzinsky AJ, Schünke M, Kurz B. Estrogen reduces mechanical injury-related cell death and proteoglycan degradation in mature articular cartilage independent of the presence of the superficial zone tissue Osteoarthritis and Cartilage. 21: 1738-1745. PMID 23863610 DOI: 10.1016/J.Joca.2013.07.007  1
2013 Zhang L, Smith DW, Gardiner BS, Grodzinsky AJ. Modeling the Insulin-Like Growth Factor System in Articular Cartilage. Plos One. 8: e66870. PMID 23840540 DOI: 10.1371/Journal.Pone.0066870  1
2013 Sankar WN, Arden N, Kim YJ, Grodzinsky AJ, Sandell L, Scanzello C, Siebenrock KA. Staging of hip osteoarthritis for clinical trials on femoroacetabular impingement Journal of the American Academy of Orthopaedic Surgeons. 21. PMID 23818189 DOI: 10.5435/Jaaos-21-07-S33  1
2013 Matheney T, Sandell L, Foucher K, Lamontagne M, Grodzinsky AJ, Peters CL. Motion analysis, cartilage mechanics, and biology in femoroacetabular impingement: current understanding and areas of future research. The Journal of the American Academy of Orthopaedic Surgeons. 21: S27-32. PMID 23818188 DOI: 10.5435/Jaaos-21-07-S27  1
2013 Rolauffs B, Kurz B, Felka T, Rothdiener M, Uynuk-Ool T, Aurich M, Frank E, Bahrs C, Badke A, Stöckle U, Aicher WK, Grodzinsky AJ. Stress-vs-time signals allow the prediction of structurally catastrophic events during fracturing of immature cartilage and predetermine the biomechanical, biochemical, and structural impairment. Journal of Structural Biology. 183: 501-11. PMID 23810923 DOI: 10.1016/J.Jsb.2013.06.011  1
2013 Smith DW, Gardiner BS, Davidson JB, Grodzinsky AJ. Computational model for the analysis of cartilage and cartilage tissue constructs. Journal of Tissue Engineering and Regenerative Medicine. PMID 23784936 DOI: 10.1002/Term.1751  1
2013 Nia HT, Bozchalooi IS, Li Y, Han L, Hung HH, Frank E, Youcef-Toumi K, Ortiz C, Grodzinsky A. High-bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment. Biophysical Journal. 104: 1529-37. PMID 23561529 DOI: 10.1016/J.Bpj.2013.02.048  1
2013 Lee CM, Kisiday JD, McIlwraith CW, Grodzinsky AJ, Frisbie DD. Synoviocytes protect cartilage from the effects of injury in vitro. Bmc Musculoskeletal Disorders. 14: 54. PMID 23374282 DOI: 10.1186/1471-2474-14-54  1
2013 Byun S, Sinskey YL, Lu YC, Ort T, Kavalkovich K, Sivakumar P, Hunziker EB, Frank EH, Grodzinsky AJ. Transport of anti-IL-6 antigen binding fragments into cartilage and the effects of injury. Archives of Biochemistry and Biophysics. 532: 15-22. PMID 23333631 DOI: 10.1016/J.Abb.2012.12.020  1
2013 Lee HY, Han L, Roughley PJ, Grodzinsky AJ, Ortiz C. Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains. Journal of Structural Biology. 181: 264-73. PMID 23270863 DOI: 10.1016/J.Jsb.2012.12.008  1
2013 Lee CM, Kisiday JD, McIlwraith CW, Grodzinsky AJ, Frisbie DD. Development of an in vitro model of injuryinduced osteoarthritis in cartilage explants from adult horses through application of single-impact compressive overload American Journal of Veterinary Research. 74: 40-47. PMID 23270344 DOI: 10.2460/Ajvr.74.1.40  1
2013 Hufeland M, Schünke M, Grodzinsky AJ, Imgenberg J, Kurz B. Response of mature meniscal tissue to a single injurious compression and interleukin-1 in vitro Osteoarthritis and Cartilage. 21: 209-216. PMID 23069857 DOI: 10.1016/J.Joca.2012.10.003  1
2013 Palukuru U, Shockley M, McGoverin C, Glenn P, Pleshko N, Spencer R, Frank E, Grodzinsky A. Assessment of changes in engineered cartilage using infrared spectroscopy and mechanical analysis Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 86-87. DOI: 10.1109/NEBEC.2013.54  1
2013 Bajpayee AG, Grodzinsky AJ. Avidin as a model for charge driven transport into cartilage: relevance to osteoarthritis drug delivery Osteoarthritis and Cartilage. 21. DOI: 10.1016/J.Joca.2013.02.607  1
2012 Ahn AC, Gow BJ, Martinsen OG, Zhao M, Grodzinsky AJ, Baikie ID. Applying the Kelvin probe to biological tissues: theoretical and computational analyses. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 85: 061901. PMID 23005121 DOI: 10.1103/Physreve.85.061901  0.04
2012 Hansson M, Swärd P, Lohmander S, Byan S, Grodzinsky A, Struglics A. Co-incubation of bovine cartilage explants with joint capsule increases aggrecan proteolysis, while mechanical injury alone does not affect the degradation Osteoarthritis and Cartilage. 20. DOI: 10.1016/J.Joca.2012.02.155  1
2011 Han L, Grodzinsky AJ, Ortiz C. Nanomechanics of the Cartilage Extracellular Matrix. Annual Review of Materials Research. 41: 133-168. PMID 22792042 DOI: 10.1146/Annurev-Matsci-062910-100431  1
2011 Nia HT, Han L, Li Y, Ortiz C, Grodzinsky A. Poroelasticity of cartilage at the nanoscale. Biophysical Journal. 101: 2304-13. PMID 22067171 DOI: 10.1016/J.Bpj.2011.09.011  1
2011 Gardiner BS, Zhang L, Smith DW, Pivonka P, Grodzinsky AJ. A mathematical model for targeting chemicals to tissues by exploiting complex degradation. Biology Direct. 6: 46. PMID 21936951 DOI: 10.1186/1745-6150-6-46  1
2011 Lu YC, Evans CH, Grodzinsky AJ. Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines. Arthritis Research & Therapy. 13: R142. PMID 21888631 DOI: 10.1186/Ar3456  1
2011 Rolauffs B, Rothdiener M, Bahrs C, Badke A, Weise K, Kuettner KE, Kurz B, Aurich M, Grodzinsky AJ, Aicher WK. Onset of preclinical osteoarthritis: the angular spatial organization permits early diagnosis. Arthritis and Rheumatism. 63: 1637-47. PMID 21630246 DOI: 10.1002/Art.30217  1
2011 Miller RE, Kopesky PW, Grodzinsky AJ. Growth factor delivery through self-assembling peptide scaffolds. Clinical Orthopaedics and Related Research. 469: 2716-24. PMID 21503788 DOI: 10.1007/S11999-011-1891-1  1
2011 Han L, Frank EH, Greene JJ, Lee HY, Hung HH, Grodzinsky AJ, Ortiz C. Time-dependent nanomechanics of cartilage. Biophysical Journal. 100: 1846-54. PMID 21463599 DOI: 10.1016/J.Bpj.2011.02.031  1
2011 Kopesky PW, Vanderploeg EJ, Kisiday JD, Frisbie DD, Sandy JD, Grodzinsky AJ. Controlled delivery of transforming growth factor β1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling. Tissue Engineering. Part A. 17: 83-92. PMID 20672992 DOI: 10.1089/Ten.Tea.2010.0198  1
2010 Miller RE, Grodzinsky AJ, Vanderploeg EJ, Lee C, Ferris DJ, Barrett MF, Kisiday JD, Frisbie DD. Effect of self-assembling peptide, chondrogenic factors, and bone marrow-derived stromal cells on osteochondral repair. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 18: 1608-19. PMID 20851201 DOI: 10.1016/J.Joca.2010.09.004  1
2010 Miller RE, Grodzinsky AJ, Cummings K, Plaas AH, Cole AA, Lee RT, Patwari P. Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate. Arthritis and Rheumatism. 62: 3686-94. PMID 20722014 DOI: 10.1002/Art.27709  1
2010 Bao G, Kamm RD, Thomas W, Hwang W, Fletcher DA, Grodzinsky AJ, Zhu C, Mofrad MR. Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function. Molecular & Cellular Biomechanics : McB. 3: 91-105. PMID 20700472 DOI: 10.1007/S12195-010-0109-Z  1
2010 Lee HY, Kopesky PW, Plaas A, Sandy J, Kisiday J, Frisbie D, Grodzinsky AJ, Ortiz C. Adult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilage. Osteoarthritis and Cartilage. 18: 1477-86. PMID 20692354 DOI: 10.1016/J.Joca.2010.07.015  1
2010 Rolauffs B, Muehleman C, Li J, Kurz B, Kuettner KE, Frank E, Grodzinsky AJ. Vulnerability of the superficial zone of immature articular cartilage to compressive injury. Arthritis and Rheumatism. 62: 3016-27. PMID 20556809 DOI: 10.1002/Art.27610  1
2010 Byun S, Tortorella MD, Malfait AM, Fok K, Frank EH, Grodzinsky AJ. Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions. Archives of Biochemistry and Biophysics. 499: 32-9. PMID 20447377 DOI: 10.1016/J.Abb.2010.04.019  1
2010 Hosseini A, Velde SKVd, Kozanek M, Gill TJ, Grodzinsky AJ, Rubash HE, Li G. In-Vivo Time-Dependent Articular Cartilage Contact Behavior Of The Tibiofemoral Joint Osteoarthritis and Cartilage. 18: 909-916. PMID 20434573 DOI: 10.1016/J.Joca.2010.04.011  1
2010 Lemke AK, Sandy JD, Voigt H, Dreier R, Lee JH, Grodzinsky AJ, Mentlein R, Fay J, Schünke M, Kurz B. Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2. Cell and Tissue Research. 340: 179-88. PMID 20217136 DOI: 10.1007/S00441-010-0941-4  1
2010 Kopesky PW, Lee HY, Vanderploeg EJ, Kisiday JD, Frisbie DD, Plaas AHK, Ortiz C, Grodzinsky AJ. Adult equine bone marrow stromal cells produce a cartilage-like ECM mechanically superior to animal-matched adult chondrocytes Matrix Biology. 29: 427-438. PMID 20153827 DOI: 10.1016/J.Matbio.2010.02.003  1
2010 Rolauffs B, Williams JM, Aurich M, Grodzinsky AJ, Kuettner KE, Cole AA. Proliferative remodeling of the spatial organization of human superficial chondrocytes distant from focal early osteoarthritis. Arthritis and Rheumatism. 62: 489-98. PMID 20112377 DOI: 10.1002/Art.27217  1
2010 Zhang L, Gardiner BS, Smith DW, Pivonka P, Grodzinsky AJ. On the role of diffusible binding partners in modulating the transport and concentration of proteins in tissues. Journal of Theoretical Biology. 263: 20-9. PMID 20005880 DOI: 10.1016/J.Jtbi.2009.11.023  1
2010 Kisiday JD, Vanderploeg EJ, McIlwraith CW, Grodzinsky AJ, Frisbie DD. Mechanical injury of explants from the articulating surface of the inner meniscus. Archives of Biochemistry and Biophysics. 494: 138-44. PMID 19944061 DOI: 10.1016/J.Abb.2009.11.022  1
2010 Lee B, Han L, Frank EH, Chubinskaya S, Ortiz C, Grodzinsky AJ. Dynamic mechanical properties of the tissue-engineered matrix associated with individual chondrocytes. Journal of Biomechanics. 43: 469-76. PMID 19889416 DOI: 10.1016/J.Jbiomech.2009.09.053  1
2010 Chai DH, Arner EC, Griggs DW, Grodzinsky AJ. Alphav and beta1 integrins regulate dynamic compression-induced proteoglycan synthesis in 3D gel culture by distinct complementary pathways. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 18: 249-56. PMID 19800448 DOI: 10.1016/J.Joca.2009.09.002  1
2010 Kopesky PW, Vanderploeg EJ, Sandy JS, Kurz B, Grodzinsky AJ. Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells. Tissue Engineering. Part A. 16: 465-77. PMID 19705959 DOI: 10.1089/Ten.Tea.2009.0158  1
2010 Miller RE, Li Y, Li J, Malfait A-, Sandy J, Plaas A, Hung H-, Frank E, Grodzinsky A. 017 Effects Of Dynamic Loading On Injured Articular Cartilage In Vitro And In Vivo Osteoarthritis and Cartilage. 18. DOI: 10.1016/S1063-4584(10)60044-1  1
2009 Sui Y, Lee JH, DiMicco MA, Vanderploeg EJ, Blake SM, Hung HH, Plaas AH, James IE, Song XY, Lark MW, Grodzinsky AJ. Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage. Arthritis and Rheumatism. 60: 2985-96. PMID 19790045 DOI: 10.1002/Art.24857  1
2009 Lee JH, Fitzgerald JB, DiMicco MA, Cheng DM, Flannery CR, Sandy JD, Plaas AH, Grodzinsky AJ. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production Archives of Biochemistry and Biophysics. 489: 118-126. PMID 19607802 DOI: 10.1016/J.Abb.2009.07.006  1
2009 Vanderploeg EJ, Grodzinsky AJ. Can the meniscus affect the nature of a chondrocyte? Osteoarthritis and Cartilage. 17: 969-970. PMID 19490964 DOI: 10.1016/J.Joca.2009.05.007  1
2009 Kisiday JD, Lee JH, Siparsky PN, Frisbie DD, Flannery CR, Sandy JD, Grodzinsky AJ. Catabolic responses of chondrocyte-seeded peptide hydrogel to dynamic compression. Annals of Biomedical Engineering. 37: 1368-75. PMID 19415495 DOI: 10.1007/S10439-009-9699-9  1
2009 Patwari P, Lin SN, Kurz B, Cole AA, Kumar S, Grodzinsky AJ. Potent inhibition of cartilage biosynthesis by coincubation with joint capsule through an IL-1-independent pathway. Scandinavian Journal of Medicine & Science in Sports. 19: 528-35. PMID 19371309 DOI: 10.1111/J.1600-0838.2009.00911.X  1
2009 Ahn AC, Grodzinsky AJ. Relevance of collagen piezoelectricity to "Wolff's Law": a critical review. Medical Engineering & Physics. 31: 733-41. PMID 19286413 DOI: 10.1016/J.Medengphy.2009.02.006  0.04
2009 Wheeler CA, Jafarzadeh SR, Rocke DM, Grodzinsky AJ. IGF-1 does not moderate the time-dependent transcriptional patterns of key homeostatic genes induced by sustained compression of bovine cartilage. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 17: 944-52. PMID 19250984 DOI: 10.1016/J.Joca.2009.02.001  1
2009 Kisiday JD, Frisbie DD, McIlwraith CW, Grodzinsky AJ. Dynamic compression stimulates proteoglycan synthesis by mesenchymal stem cells in the absence of chondrogenic cytokines. Tissue Engineering. Part A. 15: 2817-24. PMID 19243241 DOI: 10.1089/Ten.Tea.2008.0357  1
2009 Stevens AL, Wishnok JS, White FM, Grodzinsky AJ, Tannenbaum SR. Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair. Molecular & Cellular Proteomics : McP. 8: 1475-89. PMID 19196708 DOI: 10.1074/Mcp.M800181-Mcp200  1
2009 Jones AR, Chen S, Chai DH, Stevens AL, Gleghorn JP, Bonassar LJ, Grodzinsky AJ, Flannery CR. Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury. Arthritis and Rheumatism. 60: 133-42. PMID 19116897 DOI: 10.1002/Art.24143  1
2009 Kisiday JD, Frisbie DD, McIlwraith CW, Grodzinsky AJ. Dynamic compression stimulates proteoglycan synthesis by mesenchymal stem cells in the absence of chondrogenic cytokines Tissue Engineering - Part A. 15: 2817-2824. DOI: 10.1089/ten.tea.2008.0357  1
2009 Miller R, Grodzinsky A, Cummings K, Lee RT, Patwari P. 495 Heparin-Binding Igf-1 Provides Sustained Delivery Of Igf-1 To Cartilage In Vivo Osteoarthritis and Cartilage. 17. DOI: 10.1016/S1063-4584(09)60516-1  1
2008 Han L, Dean D, Daher LA, Grodzinsky AJ, Ortiz C. Cartilage aggrecan can undergo self-adhesion. Biophysical Journal. 95: 4862-70. PMID 18676640 DOI: 10.1529/Biophysj.107.128389  1
2008 Pfeiffer E, Vickers SM, Frank E, Grodzinsky AJ, Spector M. The effects of glycosaminoglycan content on the compressive modulus of cartilage engineered in type II collagen scaffolds. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 16: 1237-44. PMID 18406634 DOI: 10.1016/J.Joca.2008.02.014  1
2008 Lin Z, Fitzgerald JB, Xu J, Willers C, Wood D, Grodzinsky AJ, Zheng MH. Gene expression profiles of human chondrocytes during passaged monolayer cultivation. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 26: 1230-7. PMID 18404652 DOI: 10.1002/Jor.20523  1
2008 Rolauffs B, Williams JM, Grodzinsky AJ, Kuettner KE, Cole AA. Distinct horizontal patterns in the spatial organization of superficial zone chondrocytes of human joints. Journal of Structural Biology. 162: 335-44. PMID 18325787 DOI: 10.1016/J.Jsb.2008.01.010  1
2008 Tokunou T, Miller R, Patwari P, Davis ME, Segers VF, Grodzinsky AJ, Lee RT. Engineering insulin-like growth factor-1 for local delivery. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1886-93. PMID 18285400 DOI: 10.1096/Fj.07-100925  1
2008 Stevens AL, Wishnok JS, Chai DH, Grodzinsky AJ, Tannenbaum SR. A sodium dodecyl sulfate-polyacrylamide gel electrophoresis-liquid chromatography tandem mass spectrometry analysis of bovine cartilage tissue response to mechanical compression injury and the inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta. Arthritis and Rheumatism. 58: 489-500. PMID 18240213 DOI: 10.1002/Art.23120  1
2008 Wagner T, Eden U, Fregni F, Valero-Cabre A, Ramos-Estebanez C, Pronio-Stelluto V, Grodzinsky A, Zahn M, Pascual-Leone A. Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study. Experimental Brain Research. 186: 539-50. PMID 18193208 DOI: 10.1007/S00221-007-1258-8  1
2008 Fitzgerald JB, Jin M, Chai DH, Siparsky P, Fanning P, Grodzinsky AJ. Shear- and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants Journal of Biological Chemistry. 283: 6735-6743. PMID 18086670 DOI: 10.1074/Jbc.M708670200  1
2008 Kisiday JD, Kopesky PW, Evans CH, Grodzinsky AJ, McIlwraith CW, Frisbie DD. Evaluation of adult equine bone marrow- and adipose-derived progenitor cell chondrogenesis in hydrogel cultures. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 26: 322-31. PMID 17960654 DOI: 10.1002/Jor.20508  1
2008 Stevens AL, Wheeler CA, Tannenbaum SR, Grodzinsky AJ. Nitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-alpha but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 16: 489-97. PMID 17923423 DOI: 10.1016/J.Joca.2007.07.015  1
2008 Grodzinsky AJ, Burr DB. Twenty‐fifth anniversary of the Journal of Orthopaedic Research Journal of Orthopaedic Research. 26: 899-900. DOI: 10.1002/Jor.20705  0.01
2007 Han L, Dean D, Mao P, Ortiz C, Grodzinsky AJ. Nanoscale shear deformation mechanisms of opposing cartilage aggrecan macromolecules. Biophysical Journal. 93: L23-5. PMID 17586571 DOI: 10.1529/Biophysj.107.114025  1
2007 DiMicco MA, Kisiday JD, Gong H, Grodzinsky AJ. Structure of pericellular matrix around agarose-embedded chondrocytes Osteoarthritis and Cartilage. 15: 1207-1216. PMID 17524677 DOI: 10.1016/J.Joca.2007.03.023  1
2007 Wagner T, Fregni F, Fecteau S, Grodzinsky A, Zahn M, Pascual-Leone A. Transcranial direct current stimulation: a computer-based human model study. Neuroimage. 35: 1113-24. PMID 17337213 DOI: 10.1016/J.Neuroimage.2007.01.027  1
2007 Han L, Dean D, Ortiz C, Grodzinsky AJ. Lateral nanomechanics of cartilage aggrecan macromolecules. Biophysical Journal. 92: 1384-98. PMID 17142289 DOI: 10.1529/Biophysj.106.091397  1
2007 Zhang L, Gardiner BS, Smith DW, Pivonka P, Grodzinsky A. The effect of cyclic deformation and solute binding on solute transport in cartilage. Archives of Biochemistry and Biophysics. 457: 47-56. PMID 17107655 DOI: 10.1016/J.Abb.2006.10.007  1
2007 Ng L, Hung HH, Sprunt A, Chubinskaya S, Ortiz C, Grodzinsky A. Nanomechanical properties of individual chondrocytes and their developing growth factor-stimulated pericellular matrix. Journal of Biomechanics. 40: 1011-23. PMID 16793050 DOI: 10.1016/J.Jbiomech.2006.04.004  1
2007 Patwari P, Cheng DM, Cole AA, Kuettner KE, Grodzinsky AJ. Analysis of the relationship between peak stress and proteoglycan loss following injurious compression of human post-mortem knee and ankle cartilage. Biomechanics and Modeling in Mechanobiology. 6: 83-9. PMID 16715319 DOI: 10.1007/S10237-006-0037-Y  1
2007 Pfeiffer E, Vickers SM, Frank E, Grodzinsky A, Spector M. 15.4 The effects of glycosaminoglycan content on the compressive modulus of chondrocyte-seeded type II collagen scaffolds Osteoarthritis and Cartilage. 15. DOI: 10.1016/S1063-4584(07)61295-3  1
2007 Grodzinsky AJ, Kamm RD, Lauffenburger DA. Quantitative aspects Principles of Tissue Engineering. 251-261. DOI: 10.1016/B978-012370615-7/50022-6  1
2006 Behera AK, Hildebrand E, Szafranski J, Hung HH, Grodzinsky AJ, Lafyatis R, Koch AE, Kalish R, Perides G, Steere AC, Hu LT. Role of aggrecanase 1 in Lyme arthritis. Arthritis and Rheumatism. 54: 3319-29. PMID 17009305 DOI: 10.1002/Art.22128  1
2006 Fitzgerald JB, Jin M, Grodzinsky AJ. Shear and compression differentially regulate clusters of functionally related temporal transcription patterns in cartilage tissue. The Journal of Biological Chemistry. 281: 24095-103. PMID 16782710 DOI: 10.1074/Jbc.M510858200  1
2006 Davis ME, Hsieh PC, Takahashi T, Song Q, Zhang S, Kamm RD, Grodzinsky AJ, Anversa P, Lee RT. Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proceedings of the National Academy of Sciences of the United States of America. 103: 8155-60. PMID 16698918 DOI: 10.1073/Pnas.0602877103  1
2006 Wagner T, Fregni F, Eden U, Ramos-Estebanez C, Grodzinsky A, Zahn M, Pascual-Leone A. Transcranial magnetic stimulation and stroke: A computer-based human model study Neuroimage. 30: 857-870. PMID 16473528 DOI: 10.1016/J.Neuroimage.2005.04.046  1
2006 Dean D, Han L, Grodzinsky AJ, Ortiz C. Compressive nanomechanics of opposing aggrecan macromolecules. Journal of Biomechanics. 39: 2555-65. PMID 16289077 DOI: 10.1016/J.Jbiomech.2005.09.007  1
2006 Sui Y, Song X-, Lee JH, DiMicco M, Blake SM, Hung H-, James I, Lark MW, Grodzinsky AJ. A53 MECHANICAL INJURY POTENTIATES THE COMBINED EFFECTS OF TNF-α AND IL-6/sIL-6R ON PROTEOGLYCAN CATABOLISM IN BOVINE CARTILAGE Osteoarthritis and Cartilage. 14. DOI: 10.1016/S1063-4584(07)60506-8  1
2005 Kurz B, Lemke AK, Fay J, Pufe T, Grodzinsky AJ, Schünke M. Pathomechanisms of cartilage destruction by mechanical injury. Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft. 187: 473-85. PMID 16320827 DOI: 10.1016/J.Aanat.2005.07.003  1
2005 Bathe M, Rutledge GC, Grodzinsky AJ, Tidor B. Osmotic pressure of aqueous chondroitin sulfate solution: a molecular modeling investigation. Biophysical Journal. 89: 2357-71. PMID 16055525 DOI: 10.1529/Biophysj.105.067918  1
2005 Lee JH, Fitzgerald JB, Dimicco MA, Grodzinsky AJ. Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression. Arthritis and Rheumatism. 52: 2386-95. PMID 16052587 DOI: 10.1002/Art.21215  1
2005 Seog J, Dean D, Rolauffs B, Wu T, Genzer J, Plaas AH, Grodzinsky AJ, Ortiz C. Nanomechanics of opposing glycosaminoglycan macromolecules. Journal of Biomechanics. 38: 1789-97. PMID 16023465 DOI: 10.1016/J.Jbiomech.2004.09.010  1
2005 Davis ME, Hsieh PC, Grodzinsky AJ, Lee RT. Custom design of the cardiac microenvironment with biomaterials. Circulation Research. 97: 8-15. PMID 16002755 DOI: 10.1161/01.Res.0000173376.39447.01  1
2005 Buckwalter JA, Mankin HJ, Grodzinsky AJ. Articular cartilage and osteoarthritis. Instructional Course Lectures. 54: 465-80. PMID 15952258  0.01
2005 Bathe M, Rutledge GC, Grodzinsky AJ, Tidor B. A coarse-grained molecular model for glycosaminoglycans: application to chondroitin, chondroitin sulfate, and hyaluronic acid. Biophysical Journal. 88: 3870-87. PMID 15805173 DOI: 10.1529/Biophysj.104.058800  1
2005 Patwari P, Gao G, Lee JH, Grodzinsky AJ, Sandy JD. Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage. Osteoarthritis and Cartilage. 13: 269-77. PMID 15780640 DOI: 10.1016/J.Joca.2004.10.023  1
2005 Lu Y, Adkisson HD, Bogdanske J, Kalscheur V, Maloney W, Cheung R, Grodzinsky AJ, Hruska KA, Markel MD. In vivo transplantation of neonatal ovine neocartilage allografts: determining the effectiveness of tissue transglutaminase. The Journal of Knee Surgery. 18: 31-42. PMID 15742595  1
2005 Kisiday JD, Kurz B, DiMicco MA, Grodzinsky AJ. Evaluation of medium supplemented with insulin-transferrin-selenium for culture of primary bovine calf chondrocytes in three-dimensional hydrogel scaffolds. Tissue Engineering. 11: 141-51. PMID 15738669 DOI: 10.1089/Ten.2005.11.141  1
2005 Wheeler CA, Fitzgerald JB, Grodzinsky AJ. Cartilage mechanobiology: The response of chondrocytes to mechanical force Current Opinion in Orthopaedics. 16: 346-353. DOI: 10.1097/01.Bco.0000178255.17447.01  1
2004 Szafranski JD, Grodzinsky AJ, Burger E, Gaschen V, Hung HH, Hunziker EB. Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 12: 937-46. PMID 15564060 DOI: 10.1016/J.Joca.2004.08.004  1
2004 Bathe M, Grodzinsky AJ, Tidor B, Rutledge GC. Optimal linearized Poisson-Boltzmann theory applied to the simulation of flexible polyelectrolytes in solution. The Journal of Chemical Physics. 121: 7557-61. PMID 15485214 DOI: 10.1063/1.1808411  1
2004 Wagner TA, Zahn M, Grodzinsky AJ, Pascual-Leone A. Three-dimensional head model simulation of transcranial magnetic stimulation. Ieee Transactions On Bio-Medical Engineering. 51: 1586-98. PMID 15376507 DOI: 10.1109/Tbme.2004.827925  1
2004 Frank E, Evans R, Lee C, Treppo S, Spector M, Grodzinsky A. Quantitative electrical impedance analysis of cartilage degradation. Biorheology. 41: 195-202. PMID 15299252  1
2004 Gouze JN, Stoddart MJ, Gouze E, Palmer GD, Ghivizzani SC, Grodzinsky AJ, Evans CH. In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors. Methods in Molecular Medicine. 100: 147-64. PMID 15280594 DOI: 10.1385/1-59259-810-2:147  1
2004 Kisiday JD, Jin M, DiMicco MA, Kurz B, Grodzinsky AJ. Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds. Journal of Biomechanics. 37: 595-604. PMID 15046988 DOI: 10.1016/J.Jbiomech.2003.10.005  1
2004 DiMicco MA, Patwari P, Siparsky PN, Kumar S, Pratta MA, Lark MW, Kim YJ, Grodzinsky AJ. Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury. Arthritis and Rheumatism. 50: 840-8. PMID 15022326 DOI: 10.1002/Art.20101  1
2004 Patwari P, Gaschen V, James IE, Berger E, Blake SM, Lark MW, Grodzinsky AJ, Hunziker EB. Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilage. Osteoarthritis and Cartilage. 12: 245-52. PMID 14972342 DOI: 10.1016/J.Joca.2003.11.004  1
2004 Gouze JN, Gouze E, Palmer GD, Kaneto H, Ghivizzani SC, Grodzinsky AJ, Evans CH. Adenovirus-mediated gene transfer of glutamine: Fructose-6-phosphate amidotransferase antagonizes the effects of interluekin-1β on rat chondrocytes Osteoarthritis and Cartilage. 12: 217-224. PMID 14972338 DOI: 10.1016/J.Joca.2003.11.002  1
2004 Kisiday J, Kerin A, Grodzinsky A. Mechanical Testing of Cell-Material Constructs: A Review Methods of Molecular Biology. 238: 239-254. PMID 14970452 DOI: 10.1385/1-59259-428-X:239  1
2004 Fitzgerald JB, Jin M, Dean D, Wood DJ, Zheng MH, Grodzinsky AJ. Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP. The Journal of Biological Chemistry. 279: 19502-11. PMID 14960571 DOI: 10.1074/Jbc.M400437200  1
2004 Kurz B, Lemke A, Kehn M, Domm C, Patwari P, Frank EH, Grodzinsky AJ, Schünke M. Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression. Arthritis and Rheumatism. 50: 123-30. PMID 14730608 DOI: 10.1002/Art.11438  1
2004 Pufe T, Lemke A, Kurz B, Petersen W, Tillmann B, Grodzinsky AJ, Mentlein R. Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. The American Journal of Pathology. 164: 185-92. PMID 14695332 DOI: 10.1016/S0002-9440(10)63109-4  1
2004 Seog J, Dean DM, Frank EH, Ortiz C, Grodzinsky AJ. Preparation of end-grafted polyelectrolyte brushes on nanoscale probe tips using an electric field Macromolecules. 37: 1156-1158. DOI: 10.1021/Ma0352274  1
2004 Ng L, Grodzinsky AJ, Sandy J, Plaas A, Ortiz C. Persistence Length of Cartilage Aggrecan Macromolecules Measured via Atomic Force Microscopy Macromolecular Symposia. 214: 1-4. DOI: 10.1002/Masy.200451001  1
2003 Ng L, Grodzinsky AJ, Patwari P, Sandy J, Plaas A, Ortiz C. Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy. Journal of Structural Biology. 143: 242-57. PMID 14572479 DOI: 10.1016/J.Jsb.2003.08.006  1
2003 Fanning PJ, Emkey G, Smith RJ, Grodzinsky AJ, Szasz N, Trippel SB. Mechanical Regulation of Mitogen-activated Protein Kinase Signaling in Articular Cartilage Journal of Biological Chemistry. 278: 50940-50948. PMID 12952976 DOI: 10.1074/Jbc.M305107200  1
2003 Gouze JN, Gouze E, Palmer GD, Liew VS, Pascher A, Betz OB, Thornhill TS, Evans CH, Grodzinsky AJ, Ghivizzani SC. A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer. Arthritis Research & Therapy. 5: R301-9. PMID 12932294 DOI: 10.1186/Ar795  1
2003 Garcia AM, Szasz N, Trippel SB, Morales TI, Grodzinsky AJ, Frank EH. Transport and binding of insulin-like growth factor I through articular cartilage. Archives of Biochemistry and Biophysics. 415: 69-79. PMID 12801514 DOI: 10.1016/S0003-9861(03)00215-7  1
2003 Jin M, Emkey GR, Siparsky P, Trippel SB, Grodzinsky AJ. Combined effects of dynamic tissue shear deformation and insulin-like growth factor I on chondrocyte biosynthesis in cartilage explants. Archives of Biochemistry and Biophysics. 414: 223-31. PMID 12781774 DOI: 10.1016/S0003-9861(03)00195-4  1
2003 Patwari P, Cook MN, DiMicco MA, Blake SM, James IE, Kumar S, Cole AA, Lark MW, Grodzinsky AJ. Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines. Arthritis and Rheumatism. 48: 1292-301. PMID 12746902 DOI: 10.1002/Art.10892  1
2003 Lee JH, Kisiday J, Grodzinsky AJ. Tissue-engineered versus native cartilage: linkage between cellular mechano-transduction and biomechanical properties. Novartis Foundation Symposium. 249: 52-64; discussion 64. PMID 12708649 DOI: 10.1002/0470867973.Ch5  1
2003 Lee CR, Grodzinsky AJ, Spector M. Modulation of the contractile and biosynthetic activity of chondrocytes seeded in collagen-glycosaminoglycan matrices. Tissue Engineering. 9: 27-36. PMID 12625951 DOI: 10.1089/107632703762687500  1
2003 Lee CR, Grodzinsky AJ, Spector M. Biosynthetic response of passaged chondrocytes in a type II collagen scaffold to mechanical compression. Journal of Biomedical Materials Research. Part A. 64: 560-9. PMID 12579571 DOI: 10.1002/Jbm.A.10443  1
2003 Lee CR, Grodzinsky AJ, Hsu HP, Spector M. Effects of a cultured autologous chondrocyte-seeded type II collagen scaffold on the healing of a chondral defect in a canine model. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 21: 272-81. PMID 12568959 DOI: 10.1016/S0736-0266(02)00153-5  1
2003 Dean D, Seog J, Ortiz C, Grodzinsky AJ. Molecular-level theoretical model for electrostatic interactions within polyelectrolyte brushes: Applications to charged glycosaminoglycans Langmuir. 19: 5526-5539. DOI: 10.1021/La027001K  1
2003 Bathe M, Rutledge GC, Grodzinsky AJ, Tidor B. Towards a multi-scale model of cartilage: Coarse-graining glycosaminoglycans Computational Fluid and Solid Mechanics 2003. 1626-1630. DOI: 10.1016/B978-008044046-0.50396-1  1
2002 Quinn TM, Studer C, Grodzinsky AJ, Meister JJ. Preservation and analysis of nonequilibrium solute concentration distributions within mechanically compressed cartilage explants Journal of Biochemical and Biophysical Methods. 52: 83-95. PMID 12204413 DOI: 10.1016/S0165-022X(02)00051-9  1
2002 Kisiday J, Jin M, Kurz B, Hung H, Semino C, Zhang S, Grodzinsky AJ. Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: Implications for cartilage tissue repair Proceedings of the National Academy of Sciences of the United States of America. 99: 9996-10001. PMID 12119393 DOI: 10.1073/Pnas.142309999  1
2002 Kerin A, Patwari P, Kuettner K, Cole A, Grodzinsky A. Molecular basis of osteoarthritis: biomechanical aspects. Cellular and Molecular Life Sciences. 59: 27-35. PMID 11846029 DOI: 10.1007/S00018-002-8402-1  1
2002 Seog J, Dean D, Plaas AHK, Wong-Palms S, Grodzinsky AJ, Ortiz C. Direct measurement of glycosaminoglycan intermolecular interactions via high-resolution force spectroscopy Macromolecules. 35: 5601-5615. DOI: 10.1021/Ma0121621  1
2001 Kurz B, Jin M, Patwari P, Cheng DM, Lark MW, Grodzinsky AJ. Biosynthetic response and mechanical properties of articular cartilage after injurious compression. Journal of Orthopaedic Research. 19: 1140-1146. PMID 11781016 DOI: 10.1016/S0736-0266(01)00033-X  1
2001 Jin M, Frank EH, Quinn TM, Hunziker EB, Grodzinsky AJ. Tissue shear deformation stimulates proteoglycan and protein biosynthesis in bovine cartilage explants Archives of Biochemistry and Biophysics. 395: 41-48. PMID 11673864 DOI: 10.1006/Abbi.2001.2543  1
2001 Quinn TM, Dierickx P, Grodzinsky AJ. Glycosaminoglycan network geometry may contribute to anisotropic hydraulic permeability in cartilage under compression. Journal of Biomechanics. 34: 1483-90. PMID 11672723 DOI: 10.1016/S0021-9290(01)00103-8  1
2001 Patwari P, Fay J, Cook MN, Badger AM, Kerin AJ, Lark MW, Grodzinsky AJ. In vitro models for investigation of the effects of acute mechanical injury on cartilage. Clinical Orthopaedics and Related Research. 391. PMID 11603726 DOI: 10.1097/00003086-200110001-00007  1
2001 Lee CR, Grodzinsky AJ, Spector M. The effects of cross-linking of collagen-glycosaminoglycan scaffolds on compressive stiffness, chondrocyte-mediated contraction, proliferation and biosynthesis. Biomaterials. 22: 3145-54. PMID 11603587 DOI: 10.1016/S0142-9612(01)00067-9  1
2001 Hu LT, Eskildsen MA, Masgala C, Steere AC, Arner EC, Pratta MA, Grodzinsky AJ, Loening A, Perides G. Host metalloproteinases in lyme arthritis Arthritis and Rheumatism. 44: 1401-1410. PMID 11407701 DOI: 10.1002/1529-0131(200106)44:6<1401::Aid-Art234>3.0.Co;2-S  1
2001 Bonassar LJ, Grodzinsky AJ, Frank EH, Davila SG, Bhaktav NR, Trippel SB. The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I Journal of Orthopaedic Research. 19: 11-17. PMID 11332605 DOI: 10.1016/S0736-0266(00)00004-8  1
2001 Griffith LG, Grodzinsky AJ. Advances in biomedical engineering. Jama. 285: 556-61. PMID 11176858 DOI: 10.1001/Jama.285.5.556  0.08
2001 Jin M, Grodzinsky AJ. Effect of electrostatic interactions between glycosaminoglycans on the shear stiffness of cartilage : A molecular model and experiments Macromolecules. 34: 8330-8339. DOI: 10.1021/Ma0106604  1
2000 Grodzinsky AJ, Levenston ME, Jin M, Frank EH. Cartilage tissue remodeling in response to mechanical forces Annual Review of Biomedical Engineering. 2: 691-713. PMID 11701528 DOI: 10.1146/Annurev.Bioeng.2.1.691  1
2000 Ragan PM, Chin VI, Hung HH, Masuda K, Thonar EJ, Arner EC, Grodzinsky AJ, Sandy JD. Chondrocyte extracellular matrix synthesis and turnover are influenced by static compression in a new alginate disk culture system. Archives of Biochemistry and Biophysics. 383: 256-64. PMID 11185561 DOI: 10.1006/Abbi.2000.2060  1
2000 Lee CR, Grodzinsky AJ, Hsu HP, Martin SD, Spector M. Effects of harvest and selected cartilage repair procedures on the physical and biochemical properties of articular cartilage in the canine knee. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 18: 790-9. PMID 11117302 DOI: 10.1002/Jor.1100180517  1
2000 Treppo S, Koepp H, Quan EC, Cole AA, Kuettner KE, Grodzinsky AJ. Comparison of biomechanical and biochemical properties of cartilage from human knee and ankle pairs. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 18: 739-48. PMID 11117295 DOI: 10.1002/Jor.1100180510  1
2000 Loening AM, James IE, Levenston ME, Badger AM, Frank EH, Kurz B, Nuttall ME, Hung HH, Blake SM, Grodzinsky AJ, Lark MW. Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis. Archives of Biochemistry and Biophysics. 381: 205-12. PMID 11032407 DOI: 10.1006/Abbi.2000.1988  1
2000 Frank EH, Jin M, Loening AM, Levenston ME, Grodzinsky AJ. A versatile shear and compression apparatus for mechanical stimulation of tissue culture explants. Journal of Biomechanics. 33: 1523-7. PMID 10940414 DOI: 10.1016/S0021-9290(00)00100-7  1
2000 Bonassar LJ, Grodzinsky AJ, Srinivasan A, Davila SG, Trippel SB. Mechanical and physicochemical regulation of the action of insulin-like growth factor-I on articular cartilage Archives of Biochemistry and Biophysics. 379: 57-63. PMID 10864441 DOI: 10.1006/Abbi.2000.1820  1
2000 Bhakta NR, Garcia AM, Frank EH, Grodzinsky AJ, Morales TI. The insulin-like growth factors (IGFs) I and II bind to articular cartilage via the IGF-binding proteins. The Journal of Biological Chemistry. 275: 5860-6. PMID 10681577 DOI: 10.1074/Jbc.275.8.5860  1
2000 Patwari P, Kurz B, Sandy JD, Grodzinsky AJ. Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage. Archives of Biochemistry and Biophysics. 374: 79-85. PMID 10640399 DOI: 10.1006/Abbi.1999.1538  1
2000 Ragan PM, Badger AM, Cook M, Chin VI, Gowen M, Grodzinsky AJ, Lark MW. Down-regulation of Chondrocyte Aggrecan and Type-II Collagen Gene Expression Correlates with Increases in Static Compression Magnitude and Duration Journal of Bone and Joint Surgery, American Volume. 82: 32. DOI: 10.2106/00004623-200004000-00030  1
1999 Ragan PM, Badger AM, Cook M, Chin VI, Gowen M, Grodzinsky AJ, Lark MW. Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration. Journal of Orthopaedic Research. 17: 836-842. PMID 10632450 DOI: 10.1002/Jor.1100170608  1
1999 Quinn TM, Maung AA, Grodzinsky AJ, Hunziker EB, Sandy JD. Physical and biological regulation of proteoglycan turnover around chondrocytes in cartilage explants. Implications for tissue degradation and repair. Annals of the New York Academy of Sciences. 878: 420-41. PMID 10415746 DOI: 10.1111/J.1749-6632.1999.Tb07700.X  1
1999 Buschmann MD, Kim YJ, Wong M, Frank E, Hunziker EB, Grodzinsky AJ. Stimulation of aggrecan synthesis in cartilage explants by cyclic loading is localized to regions of high interstitial fluid flow. Archives of Biochemistry and Biophysics. 366: 1-7. PMID 10334856 DOI: 10.1006/Abbi.1999.1197  0.4
1999 Vunjak-Novakovic G, Martin I, Obradovic B, Treppo S, Grodzinsky AJ, Langer R, Freed LE. Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 17: 130-8. PMID 10073657 DOI: 10.1002/Jor.1100170119  0.32
1999 Levenston ME, Frank EH, Grodzinsky AJ, George W. Electrokinetic and poroelastic coupling during finite deformations of charged porous media Journal of Applied Mechanics, Transactions Asme. 66: 323-333. DOI: 10.1115/1.2791052  1
1998 Garcia AM, Lark MW, Trippel SB, Grodzinsky AJ. Transport of tissue inhibitor of metalloproteinases‐1 through cartilage: Contributions of fluid flow and electrical migration Journal of Orthopaedic Research. 16: 734-742. PMID 9877399 DOI: 10.1002/Jor.1100160616  1
1998 Quinn TM, Grodzinsky AJ, Hunziker EB, Sandy JD. Effects of injurious compression on matrix turnover around individual cells in calf articular cartilage explants Journal of Orthopaedic Research. 16: 490-499. PMID 9747792 DOI: 10.1002/Jor.1100160415  1
1998 Levenston ME, Frank EH, Grodzinsky AJ. Variationally derived 3-field finite element formulations for quasistatic poroelastic analysis of hydrated biological tissues Computer Methods in Applied Mechanics and Engineering. 156: 231-246. DOI: 10.1016/S0045-7825(97)00208-9  1
1998 Levenston ME, Eisenberg SR, Grodzinsky AJ. A variational formulation for coupled physicochemical flows during finite deformations of charged porous media International Journal of Solids and Structures. 35: 4999-5019. DOI: 10.1016/S0020-7683(98)00106-1  1
1997 Bonassar LJ, Sandy JD, Lark MW, Plaas AHK, Frank EH, Grodzinsky AJ. Inhibition of cartilage degradation and changes in physical properties induced by IL-1β and retinoic acid using matrix metalloproteinase inhibitors Archives of Biochemistry and Biophysics. 344: 404-412. PMID 9264555 DOI: 10.1006/Abbi.1997.0205  1
1997 Cheng GC, Briggs WH, Gerson DS, Libby P, Grodzinsky AJ, Gray ML, Lee RT. Mechanical strain tightly controls fibroblast growth factor-2 release from cultured human vascular smooth muscle cells. Circulation Research. 80: 28-36. PMID 8978319 DOI: 10.1161/01.Res.80.1.28  1
1997 Grodzinsky A, Woo S. Cartilage and soft tissue biomechanics Annals of Biomedical Engineering. 25. DOI: 10.1007/Bf02647388  0.24
1996 Whale MD, Grodzinsky AJ, Johnson M. The effect of aging and pressure on the specific hydraulic conductivity of the aortic wall Biorheology. 33: 17-44. PMID 8869342 DOI: 10.1016/0006-355X(96)00003-0  0.04
1996 Garcia AM, Frank EH, Grimshaw PE, Grodzinsky AJ. Contributions of Fluid Convection and Electrical Migration to Transport in Cartilage: Relevance to Loading Archives of Biochemistry and Biophysics. 333: 317-325. PMID 8809069 DOI: 10.1006/Abbi.1996.0397  1
1996 Kim Y, Grodzinsky AJ, Plaas AHK. Compression of Cartilage Results in Differential Effects on Biosynthetic Pathways for Aggrecan, Link Protein, and Hyaluronan Archives of Biochemistry and Biophysics. 328: 331-340. PMID 8645012 DOI: 10.1006/Abbi.1996.0181  1
1996 Sah RL, Trippel SB, Grodzinsky AJ. Differential effects of serum, insulin-like growth factor-I, and fibroblast growth factor-2 on the maintenance of cartilage physical properties during long-term culture Journal of Orthopaedic Research. 14: 44-52. PMID 8618165 DOI: 10.1002/Jor.1100140109  1
1996 Cheng GC, Libby P, Grodzinsky AJ, Lee RT. Induction of DNA synthesis by a single transient mechanical stimulus of human vascular smooth muscle cells. Role of fibroblast growth factor-2. Circulation. 93: 99-105. PMID 8616949 DOI: 10.1161/01.Cir.93.1.99  1
1995 Bonassar LJ, Jeffries KA, Paguio CG, Grodzinsky AJ. Cartilage degradation and associated changes in biomechanical and electromechanical properties Acta Orthopaedica. 66: 38-44. PMID 8553859 DOI: 10.3109/17453679509157645  1
1995 Bonassar LJ, Frank EH, Murray JC, Paguio CG, Moore VL, Lark MW, Sandy JD, Wu JJ, Eyre DR, Grodzinsky AJ. Changes in cartilage composition and physical properties due to stromelysin degradation Arthritis and Rheumatism. 38: 173-183. PMID 7848307 DOI: 10.1002/Art.1780380205  1
1995 Sachs JR, Grodzinsky AJ. Electromechanical spectroscopy of cartilage using a surface probe with applied mechanical displacement Journal of Biomechanics. 28: 963-976. PMID 7673263 DOI: 10.1016/0021-9290(94)00108-G  1
1995 Buschmann MD, Grodzinsky AJ. A Molecular Model of Proteoglycan-Associated Electrostatic Forces in Cartilage Mechanics Journal of Biomechanical Engineering-Transactions of the Asme. 117: 179-192. PMID 7666655 DOI: 10.1115/1.2796000  1
1995 Mallein-Gerin F, Ruggiero F, Quinn TM, Bard F, Grodzinsky AJ, Olsen BR, van der Rest M. Analysis of collagen synthesis and assembly in culture by immortalized mouse chondrocytes in the presence or absence of alpha 1(IX) collagen chains. Experimental Cell Research. 219: 257-65. PMID 7628541 DOI: 10.1006/Excr.1995.1226  1
1995 Kim YJ, Bonassar LJ, Grodzinsky AJ. The role of cartilage streaming potential, fluid flow and pressure in the stimulation of chondrocyte biosynthesis during dynamic compression Journal of Biomechanics. 28: 1055-1066. PMID 7559675 DOI: 10.1016/0021-9290(94)00159-2  1
1995 Bonassar LJ, Jeffries KA, Frank EH, Moore VL, Lark MW, Bayne EK, McDonnell J, Olszewski J, Hagmann W, Chapman K. In vivo effects of stromelysin on the composition and physical properties of rabbit articular cartilage in the presence and absence of a synthetic inhibitor. Arthritis and Rheumatism. 38: 1678-86. PMID 7488290 DOI: 10.1002/Art.1780381121  1
1995 Berkenblit SI, Quinn TM, Grodzinsky AJ. Molecular electromechanics of cartilaginous tissues and polyelectrolyte gels Journal of Electrostatics. 34: 307-330. DOI: 10.1016/0304-3886(95)98192-M  1
1995 Mallein‐Gerin F, Ruggiero F, Quinn TM, Bard F, Grodzinsky AJ, Olsen BR, Van der Rest M. Immortalization of chondrocytes from normal and mutant mice provides a tool to analyze cartilage matrix structure and differentiation Biology of the Cell. 84: 121-121. DOI: 10.1016/0248-4900(96)81470-5  1
1994 Sah RL, Chen AC, Grodzinsky AJ, Trippel S. Differential Effects of bFGF and IGF-I on Matrix Metabolism in Calf and Adult Bovine Cartilage Explants Archives of Biochemistry and Biophysics. 308: 137-147. PMID 8311446 DOI: 10.1006/Abbi.1994.1020  1
1994 Kim YJ, Sah RL, Grodzinsky AJ, Plaas AH, Sandy JD. Mechanical regulation of cartilage biosynthetic behavior: physical stimuli. Archives of Biochemistry and Biophysics. 311: 1-12. PMID 8185305 DOI: 10.1006/Abbi.1994.1201  0.48
1994 Macginitie LA, Gluzband YA, Grodzinsky AJ. Electric field stimulation can increase protein synthesis in articular cartilage explants Journal of Orthopaedic Research. 12: 151-160. PMID 8164086 DOI: 10.1002/Jor.1100120202  1
1994 Loree HM, Grodzinsky AJ, Park SY, Gibson LJ, Lee RT. Static circumferential tangential modulus of human atherosclerotic tissue Journal of Biomechanics. 27: 195-204. PMID 8132688 DOI: 10.1016/0021-9290(94)90209-7  1
1994 Bonassar LJ, Paguio CG, Frank EH, Jeffries KA, Moore VL, Lark MW, Caldwell CG, Hagmann WK, Grodzinsky AJ. Effects of matrix metalloproteinases on cartilage biophysical properties in vitro and in vivo Annals of the New York Academy of Sciences. 732: 439-443. PMID 7978833 DOI: 10.1111/J.1749-6632.1994.Tb24779.X  1
1994 Berkenblit SI, Frank EH, Salant EP, Grodzinsky AJ. Nondestructive Detection of Cartilage Degeneration Using Electromechanical Surface Spectroscopy Journal of Biomechanical Engineering-Transactions of the Asme. 116: 384-392. PMID 7869713 DOI: 10.1115/1.2895788  1
1993 Basser PJ, Grodzinsky AJ. The Donnan model derived from microstructure Biophysical Chemistry. 46: 57-68. PMID 8443336 DOI: 10.1016/0301-4622(93)87007-J  1
1993 Shefer A, Grodzinsky AJ, Prime KL, Busnel JP. Novel model networks of poly(acrylic acid): synthesis and characterization Macromolecules. 26: 5009-5014. DOI: 10.1021/Ma00071A004  0.01
1993 Quinn TM, Grodzinsky AJ. Longitudinal modulus and hydraulic permeability of poly(methacrylic acid) gels: effects of charge density and solvent content Macromolecules. 26: 4332-4338. DOI: 10.1021/Ma00068A040  1
1993 Shefer A, Grodzinsky AJ, Prime KL, Busnel JP. Free-radical telomerization of tert-butyl acrylate in the presence of bis(4-aminophenyl) disulfide as a useful route to amino-terminated telomers of poly(acrylic acid) Macromolecules. 26: 2240-2245. DOI: 10.1021/Ma00061A016  0.01
1992 Lee RT, Richardson SG, Loree HM, Grodzinsky AJ, Gharib SA, Schoen FJ, Pandian N. Prediction of mechanical properties of human atherosclerotic tissue by high-frequency intravascular ultrasound imaging. An in vitro study. Arteriosclerosis, Thrombosis, and Vascular Biology. 12: 1-5. PMID 1731852 DOI: 10.1161/01.Atv.12.1.1  1
1992 Edelman ER, Fiorino A, Grodzinsky A, Langer R. Mechanical deformation of polymer matrix controlled release devices modulates drug release. Journal of Biomedical Materials Research. 26: 1619-31. PMID 1484066 DOI: 10.1002/Jbm.820261207  0.12
1992 Buschmann MD, Gluzband YA, Grodzinsky AJ, Kimura JH, Hunziker EB. Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix. Journal of Orthopaedic Research. 10: 745-758. PMID 1403287 DOI: 10.1002/Jor.1100100602  1
1991 Sah RLY, Doong JYH, Grodzinsky AJ, Plaas AHK, Sandy JD. Effects of compression on the loss of newly synthesized proteoglycans and proteins from cartilage explants Archives of Biochemistry and Biophysics. 286: 20-29. PMID 1897947 DOI: 10.1016/0003-9861(91)90004-3  1
1991 Weiss AM, Adler KP, Grodzinsky AJ, Yarmush ML. Variable permeability membranes: Network structure of poly (methacrylic acid) and its relation to diffusive transport Journal of Membrane Science. 58: 153-173. DOI: 10.1016/S0376-7388(00)82453-9  1
1991 Lee RT, Richardson SG, Grodzinsky AJ, Loree HM, Gharib SA, Tong L, Pandian N. Prediction of mechanical properties of human atherosclerotic tissue by high-frequency intravascular ultrasound imaging Journal of the American College of Cardiology. 17. DOI: 10.1016/0735-1097(91)91342-C  1
1990 Sah RL, Grodzinsky AJ, Plaas AH, Sandy JD. Effects of tissue compression on the hyaluronate-binding properties of newly synthesized proteoglycans in cartilage explants. The Biochemical Journal. 267: 803-8. PMID 2339990 DOI: 10.1042/Bj2670803  0.36
1990 Grimshaw PE, Nussbaum JH, Grodzinsky AJ, Yarmush ML. Kinetics of electrically and chemically induced swelling in polyelectrolyte gels The Journal of Chemical Physics. 93: 4462-4472. DOI: 10.1063/1.458729  1
1990 Grimshaw PE, Grodzinsky AJ, Yarmush ML, Yarmush DM. Selective augmentation of macromolecular transport in gels by electrodiffusion and electrokinetics Chemical Engineering Science. 45: 2917-2929. DOI: 10.1016/0009-2509(90)80183-F  1
1989 Sah RL‐, Kim Y‐, Doong JH, Grodzinsky AJ, Plass AHK, Sandy JD. Biosynthetic response of cartilage explants to dynamic compression Journal of Orthopaedic Research. 7: 619-636. PMID 2760736 DOI: 10.1002/Jor.1100070502  1
1989 Gray ML, Pizzanelli AM, Lee RC, Grodzinsky AJ, Swann DA. Kinetics of the chondrocyte biosynthetic response to compressive load and release. Biochimica Et Biophysica Acta. 991: 415-25. PMID 2730919 DOI: 10.1016/0304-4165(89)90067-6  1
1989 Weiss AM, Grodzinsky AJ. Fluorescence techniques for the characterization of polymeric membranes whose permeability can be varied in real time Proceedings of Spie - the International Society For Optical Engineering. 1038: 36-43. DOI: 10.1117/12.951031  1
1989 Grimshaw PE, Grodzinsky AJ, Yarmush ML, Yarmush DM. Dynamic membranes for protein transport: chemical and electrical control Chemical Engineering Science. 44: 827-840. DOI: 10.1016/0009-2509(89)85256-X  1
1988 Gray ML, Pizzanelli AM, Grodzinsky AJ, Lee RC. Mechanical and physiochemical determinants of the chondrocyte biosynthetic response. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 6: 777-92. PMID 3171760 DOI: 10.1002/Jor.1100060602  1
1988 Kim YJ, Sah RLY, Doong JYH, Grodzinsky AJ. Fluorometric assay of DNA in cartilage explants using Hoechst 33258 Analytical Biochemistry. 174: 168-176. PMID 2464289 DOI: 10.1016/0003-2697(88)90532-5  1
1987 Frank EH, Grodzinsky AJ, Koob TJ, Eyre DR. Streaming potentials: a sensitive index of enzymatic degradation in articular cartilage. Journal of Orthopaedic Research. 5: 497-508. PMID 3681524 DOI: 10.1002/Jor.1100050405  1
1987 Frank EH, Grodzinsky AJ. Cartilage electromechanics—II. A continuum model of cartilage electrokinetics and correlation with experiments Journal of Biomechanics. 20: 629-639. PMID 3611138 DOI: 10.1016/0021-9290(87)90283-1  1
1987 Frank EH, Grodzinsky AJ. Cartilage electromechanics--I. Electrokinetic transduction and the effects of electrolyte pH and ionic strength. Journal of Biomechanics. 20: 615-627. PMID 3611137 DOI: 10.1016/0021-9290(87)90282-X  1
1987 Valleton J, Grodzinsky AJ, Selegny E. Theoretical study of mechano-chemical couplings in a compartmental enzyme system: I. Analytical treatment Biophysical Chemistry. 26: 29-38. PMID 3593878 DOI: 10.1016/0301-4622(87)80004-2  0.01
1987 Eisenberg SR, Grodzinsky AJ. The kinetics of chemically induced nonequilibrium swelling of articular cartilage and corneal stroma. Journal of Biomechanical Engineering. 109: 79-89. PMID 3560885 DOI: 10.1115/1.3138647  1
1987 Lavine LS, Grodzinsky AJ. Electrical stimulation of repair of bone. Journal of Bone and Joint Surgery, American Volume. 69: 626-630. DOI: 10.2106/00004623-198769040-00024  0.01
1986 Valleton J, Grodzinsky AJ. Conductivity-mediated regulation in a compartmental enzyme system. Superactivation and conductance bistability. Biophysical Chemistry. 24: 277-284. PMID 3768471 DOI: 10.1016/0301-4622(86)85032-3  0.01
1985 Eisenberg SR, Grodzinsky AJ. Swelling of articular cartilage and other connective tissues: electromechanochemical forces. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 3: 148-59. PMID 3998893 DOI: 10.1002/Jor.1100030204  1
1985 Grodzinsky AJ, Weiss AM. Electric Field Control of Membrane Transport and Separations Separation &Amp; Purification Reviews. 14: 1-40. DOI: 10.1080/03602548508068410  1
1984 Eisenberg SR, Grodzinsky AJ. Electrically modulated membrane permeability Journal of Membrane Science. 19: 173-194. DOI: 10.1016/S0376-7388(00)80207-0  1
1983 Grodzinsky AJ, Hey LA. Skeletal Tissue Electromechanics & Electrical Stimulation of Growth & Remodeling Ieee Engineering in Medicine and Biology Magazine. 2: 18-22. PMID 19493717 DOI: 10.1109/Memb.1983.5005986  0.01
1983 Hoch DH, Grodzinsky AJ, Koob TJ, Albert ML, Eyre DR. Early changes in material properties of rabbit articular cartilage after meniscectomy. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 1: 4-12. PMID 6689609 DOI: 10.1002/Jor.1100010102  1
1982 Grodzinsky AJ, Chen TL, Newton DW. Physical characterization of electrosurgical coagulation. Journal of Surgical Research. 33: 469-481. PMID 7144162 DOI: 10.1016/0022-4804(82)90064-6  0.01
1981 Lee RC, Frank EH, Grodzinsky AJ, Roylance DK. Oscillatory compressional behavior of articular cartilage and its associated electromechanical properties. Journal of Biomechanical Engineering-Transactions of the Asme. 103: 280-292. PMID 7311495 DOI: 10.1115/1.3138294  1
1981 Nussbaum JH, Grodzinsky AJ. Proton diffusion reaction in a protein polyelectrolyte membrane and the kinetics of electromechanical forces Journal of Membrane Science. 8: 193-219. DOI: 10.1016/S0376-7388(00)82090-6  1
1980 Shoenfeld NA, Grodzinsky AJ. Contribution of electrodiffusion to the dynamics of electrically stimulated changes in mechanical properties of collagen membranes. Biopolymers. 19: 241-262. PMID 7370398 DOI: 10.1002/Bip.1980.360190204  0.01
1978 Grodzinsky AJ, Lipshitz H, Glimcher MJ. Electromechanical properties of articular cartilage during compression and stress relaxation. Nature. 275: 448-50. PMID 29231 DOI: 10.1038/275448A0  1
1978 Grodzinsky AJ, Eisenberg SR. Double layer mediated energy conversion with a protein membrane using an imposed frequency and wavelength Journal of Electrostatics. 5: 33-50. DOI: 10.1016/0304-3886(78)90006-2  1
1976 Grodzinsky AJ, Melcher JR. Electromechanical transduction with charged polyelectrolyte membranes. Ieee Transactions On Bio-Medical Engineering. 23: 421-33. PMID 977010 DOI: 10.1109/Tbme.1976.324600  1
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