Alan Jay Grodzinsky - Publications

Massachusetts Institute of Technology, Cambridge, MA, United States 

94 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Connizzo BK, Grodzinsky AJ. Lose-Dose Administration of Dexamethasone is Beneficial in Preventing Secondary Tendon Damage in a Stress-Deprived Joint Injury Explant Model. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 31441099 DOI: 10.1002/jor.24451  1
2019 Connizzo BK, Piet JM, Shefelbine SJ, Grodzinsky AJ. Age-associated changes in the response of tendon explants to stress deprivation is sex-dependent. Connective Tissue Research. 1-15. PMID 31411079 DOI: 10.1080/03008207.2019.1648444  1
2019 Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, ... ... Grodzinsky AJ, et al. Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nature Biomedical Engineering. 3: 230-245. PMID 30948807 DOI: 10.1038/s41551-018-0334-7  1
2019 Sellon JB, Azadi M, Oftadeh R, Nia HT, Ghaffari R, Grodzinsky AJ, Freeman DM. Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections. Physical Review Letters. 122: 028101. PMID 30720330 DOI: 10.1103/PhysRevLett.122.028101  1
2018 Connizzo BK, Grodzinsky AJ. Release of Pro-Inflammatory Cytokines from Muscle and Bone Causes Tenocyte Death in a Novel Rotator Cuff In Vitro Explant Culture Model. Connective Tissue Research. PMID 29447021 DOI: 10.1080/03008207.2018.1439486  1
2018 Oftadeh R, Connizzo BK, Nia HT, Ortiz C, Grodzinsky AJ. Biological connective tissues exhibit viscoelastic and poroelastic behavior at different frequency regimes: application to tendon and skin biophysics. Acta Biomaterialia. PMID 29425716 DOI: 10.1016/j.actbio.2018.01.041  1
2018 Connizzo BK, Grodzinsky AJ. Multiscale Poroviscoelastic Compressive Properties of Mouse Supraspinatus Tendons Are Altered in Young and Aged Mice. Journal of Biomechanical Engineering. 140. PMID 29238818 DOI: 10.1115/1.4038745  1
2017 Han B, Nia HT, Wang C, Chandrasekaran P, Li Q, Chery DR, Li H, Grodzinsky AJ, Han L. AFM-Nanomechanical Test: An Interdisciplinary Tool That Links the Understanding of Cartilage and Meniscus Biomechanics, Osteoarthritis Degeneration, and Tissue Engineering. Acs Biomaterials Science & Engineering. 3: 2033-2049. PMID 31423463 DOI: 10.1021/acsbiomaterials.7b00307  1
2017 Connizzo BK, Grodzinsky AJ. Tendon exhibits complex poroelastic behavior at the nanoscale as revealed by high-frequency AFM-based rheology. Journal of Biomechanics. 54: 11-18. PMID 28233551 DOI: 10.1016/j.jbiomech.2017.01.029  1
2016 Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, ... Grodzinsky AJ, et al. Solid stress and elastic energy as measures of tumour mechanopathology. Nature Biomedical Engineering. 1. PMID 28966873 DOI: 10.1038/s41551-016-0004  1
2016 Hajjarian Z, Nia HT, Ahn S, Grodzinsky AJ, Jain RK, Nadkarni SK. Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds. Scientific Reports. 6: 37949. PMID 27905494 DOI: 10.1038/srep37949  1
2016 Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, ... ... Grodzinsky AJ, et al. Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Science Translational Medicine. 8: 360ra135. PMID 27733559 DOI: 10.1126/scitranslmed.aaf5219  1
2016 Liebesny PH, Byun S, Hung HH, Pancoast JR, Mroszczyk KA, Young W, Lee RT, Frisbie DD, Kisiday J, Grodzinsky AJ. Growth factor-mediated migration of bone marrow progenitor cells for accelerated scaffold recruitment. Tissue Engineering. Part A. PMID 27268956 DOI: 10.1089/ten.TEA.2015.0524  1
2016 Azadi M, Nia HT, Gauci SJ, Ortiz C, Fosang AJ, Grodzinsky AJ. Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse. Journal of Biomechanics. PMID 27086115 DOI: 10.1016/j.jbiomech.2016.03.055  1
2016 Felka T, Rothdiener M, Bast S, Uynuk-Ool T, Zouhair S, Ochs BG, De Zwart P, Stoeckle U, Aicher WK, Hart ML, Shiozawa T, Grodzinsky AJ, Schenke-Layland K, Venkatesan JK, Cucchiarini M, et al. Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. PMID 26879798 DOI: 10.1016/j.joca.2016.02.001  1
2016 Kar S, Smith DW, Gardiner BS, Li Y, Wang Y, Grodzinsky AJ. Modeling IL-1 induced degradation of articular cartilage. Archives of Biochemistry and Biophysics. PMID 26874194 DOI: 10.1016/  1
2015 Scarcelli G, Polacheck WJ, Nia HT, Patel K, Grodzinsky AJ, Kamm RD, Yun SH. Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy. Nature Methods. PMID 26436482 DOI: 10.1038/nmeth.3616  1
2015 Bae JH, Hosseini A, Wang Y, Torriani M, Gill TJ, Grodzinsky AJ, Li G. Articular cartilage of the knee 3 years after ACL reconstruction. Acta Orthopaedica. 1-6. PMID 25854533 DOI: 10.3109/17453674.2015.1039426  1
2015 Li Q, Doyran B, Gamer LW, Lu XL, Qin L, Ortiz C, Grodzinsky AJ, Rosen V, Han L. Biomechanical properties of murine meniscus surface via AFM-based nanoindentation. Journal of Biomechanics. 48: 1364-70. PMID 25817332 DOI: 10.1016/j.jbiomech.2015.02.064  1
2015 Nia HT, Han L, Bozchalooi IS, Roughley P, Youcef-Toumi K, Grodzinsky AJ, Ortiz C. Aggrecan nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties. Acs Nano. 9: 2614-25. PMID 25758717 DOI: 10.1021/nn5062707  1
2015 Bajpayee AG, Scheu M, Grodzinsky AJ, Porter RM. A rabbit model demonstrates the influence of cartilage thickness on intra-articular drug delivery and retention within cartilage. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 33: 660-7. PMID 25627105 DOI: 10.1002/jor.22841  1
2015 Lee B, Han L, Frank EH, Grodzinsky AJ, Ortiz C. Dynamic nanomechanics of individual bone marrow stromal cells and cell-matrix composites during chondrogenic differentiation. Journal of Biomechanics. 48: 171-5. PMID 25468666 DOI: 10.1016/j.jbiomech.2014.11.005  1
2015 Nia HT, Gauci SJ, Azadi M, Hung HH, Frank E, Fosang AJ, Ortiz C, Grodzinsky AJ. High-bandwidth AFM-based rheology is a sensitive indicator of early cartilage aggrecan degradation relevant to mouse models of osteoarthritis. Journal of Biomechanics. 48: 162-5. PMID 25435386 DOI: 10.1016/j.jbiomech.2014.11.012  1
2015 Zhang L, Miramini S, Smith DW, Gardiner BS, Grodzinsky AJ. Time evolution of deformation in a human cartilage under cyclic loading. Annals of Biomedical Engineering. 43: 1166-77. PMID 25331101 DOI: 10.1007/s10439-014-1164-8  1
2015 Florine EM, Miller RE, Liebesny PH, Mroszczyk KA, Lee RT, Patwari P, Grodzinsky AJ. Delivering heparin-binding insulin-like growth factor 1 with self-assembling peptide hydrogels. Tissue Engineering. Part A. 21: 637-46. PMID 25231349 DOI: 10.1089/ten.TEA.2013.0679  1
2014 Miller RE, Grodzinsky AJ, Barrett MF, Hung HH, Frank EH, Werpy NM, McIlwraith CW, Frisbie DD. Effects of the combination of microfracture and self-assembling Peptide filling on the repair of a clinically relevant trochlear defect in an equine model. The Journal of Bone and Joint Surgery. American Volume. 96: 1601-9. PMID 25274785 DOI: 10.2106/JBJS.M.01408  1
2014 Batista MA, Nia HT, Önnerfjord P, Cox KA, Ortiz C, Grodzinsky AJ, Heinegård D, Han L. Nanomechanical phenotype of chondroadherin-null murine articular cartilage. Matrix Biology : Journal of the International Society For Matrix Biology. 38: 84-90. PMID 24892719 DOI: 10.1016/j.matbio.2014.05.008  1
2014 Irrechukwu ON, Thaer SV, Frank EH, Lin PC, Reiter DA, Grodzinsky AJ, Spencer RG. Prediction of cartilage compressive modulus using multiexponential analysis of T(2) relaxation data and support vector regression. Nmr in Biomedicine. 27: 468-77. PMID 24519878 DOI: 10.1002/nbm.3083  1
2014 Rojas FP, Batista MA, Lindburg CA, Dean D, Grodzinsky AJ, Ortiz C, Han L. Molecular adhesion between cartilage extracellular matrix macromolecules. Biomacromolecules. 15: 772-80. PMID 24491174 DOI: 10.1021/bm401611b  1
2014 Ogawa H, Kozhemyakina E, Hung HH, Grodzinsky AJ, Lassar AB. Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways. Genes & Development. 28: 127-39. PMID 24449269 DOI: 10.1101/gad.231969.113  1
2014 Bajpayee AG, Wong CR, Bawendi MG, Frank EH, Grodzinsky AJ. Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis. Biomaterials. 35: 538-49. PMID 24120044 DOI: 10.1016/j.biomaterials.2013.09.091  1
2014 Wagner T, Eden U, Rushmore J, Russo CJ, Dipietro L, Fregni F, Simon S, Rotman S, Pitskel NB, Ramos-Estebanez C, Pascual-Leone A, Grodzinsky AJ, Zahn M, Valero-Cabré A. Impact of brain tissue filtering on neurostimulation fields: a modeling study. Neuroimage. 85: 1048-57. PMID 23850466 DOI: 10.1016/j.neuroimage.2013.06.079  1
2014 Kopesky PW, Byun S, Vanderploeg EJ, Kisiday JD, Frisbie DD, Grodzinsky AJ. Sustained delivery of bioactive TGF-β1 from self-assembling peptide hydrogels induces chondrogenesis of encapsulated bone marrow stromal cells. Journal of Biomedical Materials Research. Part A. 102: 1275-85. PMID 23650117 DOI: 10.1002/jbm.a.34789  1
2013 Florine EM, Miller RE, Porter RM, Evans CH, Kurz B, Grodzinsky AJ. Effects of Dexamethasone on Mesenchymal Stromal Cell Chondrogenesis and Aggrecanase Activity: Comparison of Agarose and Self-Assembling Peptide Scaffolds. Cartilage. 4: 63-74. PMID 24533173 DOI: 10.1177/1947603512455196  1
2013 Byun S, Sinskey YL, Lu YC, Frank EH, Grodzinsky AJ. Transport and binding of tumor necrosis factor-α in articular cartilage depend on its quaternary structure. Archives of Biochemistry and Biophysics. 540: 1-8. PMID 24135706 DOI: 10.1016/  1
2013 Li Y, Frank EH, Wang Y, Chubinskaya S, Huang HH, Grodzinsky AJ. Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-α and interleukin-6, but accentuates degradation above a strain threshold. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 21: 1933-41. PMID 24007885 DOI: 10.1016/j.joca.2013.08.021  1
2013 Zhang L, Smith DW, Gardiner BS, Grodzinsky AJ. Modeling the Insulin-Like Growth Factor System in Articular Cartilage. Plos One. 8: e66870. PMID 23840540 DOI: 10.1371/journal.pone.0066870  1
2013 Sankar WN, Arden N, Kim YJ, Grodzinsky AJ, Sandell L, Scanzello C, Siebenrock KA. Staging of hip osteoarthritis for clinical trials on femoroacetabular impingement Journal of the American Academy of Orthopaedic Surgeons. 21. PMID 23818189 DOI: 10.5435/JAAOS-21-07-S33  1
2013 Matheney T, Sandell L, Foucher K, Lamontagne M, Grodzinsky AJ, Peters CL. Motion analysis, cartilage mechanics, and biology in femoroacetabular impingement: current understanding and areas of future research. The Journal of the American Academy of Orthopaedic Surgeons. 21: S27-32. PMID 23818188 DOI: 10.5435/JAAOS-21-07-S27  1
2013 Rolauffs B, Kurz B, Felka T, Rothdiener M, Uynuk-Ool T, Aurich M, Frank E, Bahrs C, Badke A, Stöckle U, Aicher WK, Grodzinsky AJ. Stress-vs-time signals allow the prediction of structurally catastrophic events during fracturing of immature cartilage and predetermine the biomechanical, biochemical, and structural impairment. Journal of Structural Biology. 183: 501-11. PMID 23810923 DOI: 10.1016/j.jsb.2013.06.011  1
2013 Smith DW, Gardiner BS, Davidson JB, Grodzinsky AJ. Computational model for the analysis of cartilage and cartilage tissue constructs. Journal of Tissue Engineering and Regenerative Medicine. PMID 23784936 DOI: 10.1002/term.1751  1
2013 Nia HT, Bozchalooi IS, Li Y, Han L, Hung HH, Frank E, Youcef-Toumi K, Ortiz C, Grodzinsky A. High-bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment. Biophysical Journal. 104: 1529-37. PMID 23561529 DOI: 10.1016/j.bpj.2013.02.048  1
2013 Lee HY, Han L, Roughley PJ, Grodzinsky AJ, Ortiz C. Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains. Journal of Structural Biology. 181: 264-73. PMID 23270863 DOI: 10.1016/j.jsb.2012.12.008  1
2013 Lee CM, Kisiday JD, McIlwraith CW, Grodzinsky AJ, Frisbie DD. Development of an in vitro model of injuryinduced osteoarthritis in cartilage explants from adult horses through application of single-impact compressive overload American Journal of Veterinary Research. 74: 40-47. PMID 23270344 DOI: 10.2460/ajvr.74.1.40  1
2011 Han L, Grodzinsky AJ, Ortiz C. Nanomechanics of the Cartilage Extracellular Matrix. Annual Review of Materials Research. 41: 133-168. PMID 22792042 DOI: 10.1146/annurev-matsci-062910-100431  1
2011 Nia HT, Han L, Li Y, Ortiz C, Grodzinsky A. Poroelasticity of cartilage at the nanoscale. Biophysical Journal. 101: 2304-13. PMID 22067171 DOI: 10.1016/j.bpj.2011.09.011  1
2011 Gardiner BS, Zhang L, Smith DW, Pivonka P, Grodzinsky AJ. A mathematical model for targeting chemicals to tissues by exploiting complex degradation. Biology Direct. 6: 46. PMID 21936951 DOI: 10.1186/1745-6150-6-46  1
2011 Rolauffs B, Rothdiener M, Bahrs C, Badke A, Weise K, Kuettner KE, Kurz B, Aurich M, Grodzinsky AJ, Aicher WK. Onset of preclinical osteoarthritis: the angular spatial organization permits early diagnosis. Arthritis and Rheumatism. 63: 1637-47. PMID 21630246 DOI: 10.1002/art.30217  1
2011 Miller RE, Kopesky PW, Grodzinsky AJ. Growth factor delivery through self-assembling peptide scaffolds. Clinical Orthopaedics and Related Research. 469: 2716-24. PMID 21503788 DOI: 10.1007/s11999-011-1891-1  1
2011 Han L, Frank EH, Greene JJ, Lee HY, Hung HH, Grodzinsky AJ, Ortiz C. Time-dependent nanomechanics of cartilage. Biophysical Journal. 100: 1846-54. PMID 21463599 DOI: 10.1016/j.bpj.2011.02.031  1
2011 Kopesky PW, Vanderploeg EJ, Kisiday JD, Frisbie DD, Sandy JD, Grodzinsky AJ. Controlled delivery of transforming growth factor β1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling. Tissue Engineering. Part A. 17: 83-92. PMID 20672992 DOI: 10.1089/ten.TEA.2010.0198  1
2010 Miller RE, Grodzinsky AJ, Vanderploeg EJ, Lee C, Ferris DJ, Barrett MF, Kisiday JD, Frisbie DD. Effect of self-assembling peptide, chondrogenic factors, and bone marrow-derived stromal cells on osteochondral repair. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 18: 1608-19. PMID 20851201 DOI: 10.1016/j.joca.2010.09.004  1
2010 Miller RE, Grodzinsky AJ, Cummings K, Plaas AH, Cole AA, Lee RT, Patwari P. Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate. Arthritis and Rheumatism. 62: 3686-94. PMID 20722014 DOI: 10.1002/art.27709  1
2010 Bao G, Kamm RD, Thomas W, Hwang W, Fletcher DA, Grodzinsky AJ, Zhu C, Mofrad MR. Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function. Molecular & Cellular Biomechanics : McB. 3: 91-105. PMID 20700472 DOI: 10.1007/s12195-010-0109-z  1
2010 Kopesky PW, Lee HY, Vanderploeg EJ, Kisiday JD, Frisbie DD, Plaas AHK, Ortiz C, Grodzinsky AJ. Adult equine bone marrow stromal cells produce a cartilage-like ECM mechanically superior to animal-matched adult chondrocytes Matrix Biology. 29: 427-438. PMID 20153827 DOI: 10.1016/j.matbio.2010.02.003  1
2010 Rolauffs B, Williams JM, Aurich M, Grodzinsky AJ, Kuettner KE, Cole AA. Proliferative remodeling of the spatial organization of human superficial chondrocytes distant from focal early osteoarthritis. Arthritis and Rheumatism. 62: 489-98. PMID 20112377 DOI: 10.1002/art.27217  1
2010 Kisiday JD, Vanderploeg EJ, McIlwraith CW, Grodzinsky AJ, Frisbie DD. Mechanical injury of explants from the articulating surface of the inner meniscus. Archives of Biochemistry and Biophysics. 494: 138-44. PMID 19944061 DOI: 10.1016/  1
2010 Lee B, Han L, Frank EH, Chubinskaya S, Ortiz C, Grodzinsky AJ. Dynamic mechanical properties of the tissue-engineered matrix associated with individual chondrocytes. Journal of Biomechanics. 43: 469-76. PMID 19889416 DOI: 10.1016/j.jbiomech.2009.09.053  1
2010 Chai DH, Arner EC, Griggs DW, Grodzinsky AJ. Alphav and beta1 integrins regulate dynamic compression-induced proteoglycan synthesis in 3D gel culture by distinct complementary pathways. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 18: 249-56. PMID 19800448 DOI: 10.1016/j.joca.2009.09.002  1
2010 Kopesky PW, Vanderploeg EJ, Sandy JS, Kurz B, Grodzinsky AJ. Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells. Tissue Engineering. Part A. 16: 465-77. PMID 19705959 DOI: 10.1089/ten.TEA.2009.0158  1
2009 Sui Y, Lee JH, DiMicco MA, Vanderploeg EJ, Blake SM, Hung HH, Plaas AH, James IE, Song XY, Lark MW, Grodzinsky AJ. Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage. Arthritis and Rheumatism. 60: 2985-96. PMID 19790045 DOI: 10.1002/art.24857  1
2009 Lee JH, Fitzgerald JB, DiMicco MA, Cheng DM, Flannery CR, Sandy JD, Plaas AH, Grodzinsky AJ. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production Archives of Biochemistry and Biophysics. 489: 118-126. PMID 19607802 DOI: 10.1016/  1
2009 Patwari P, Lin SN, Kurz B, Cole AA, Kumar S, Grodzinsky AJ. Potent inhibition of cartilage biosynthesis by coincubation with joint capsule through an IL-1-independent pathway. Scandinavian Journal of Medicine & Science in Sports. 19: 528-35. PMID 19371309 DOI: 10.1111/j.1600-0838.2009.00911.x  1
2009 Wheeler CA, Jafarzadeh SR, Rocke DM, Grodzinsky AJ. IGF-1 does not moderate the time-dependent transcriptional patterns of key homeostatic genes induced by sustained compression of bovine cartilage. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 17: 944-52. PMID 19250984 DOI: 10.1016/j.joca.2009.02.001  1
2009 Stevens AL, Wishnok JS, White FM, Grodzinsky AJ, Tannenbaum SR. Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair. Molecular & Cellular Proteomics : McP. 8: 1475-89. PMID 19196708 DOI: 10.1074/mcp.M800181-MCP200  1
2009 Jones AR, Chen S, Chai DH, Stevens AL, Gleghorn JP, Bonassar LJ, Grodzinsky AJ, Flannery CR. Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury. Arthritis and Rheumatism. 60: 133-42. PMID 19116897 DOI: 10.1002/art.24143  1
2008 Han L, Dean D, Daher LA, Grodzinsky AJ, Ortiz C. Cartilage aggrecan can undergo self-adhesion. Biophysical Journal. 95: 4862-70. PMID 18676640 DOI: 10.1529/biophysj.107.128389  1
2008 Rolauffs B, Williams JM, Grodzinsky AJ, Kuettner KE, Cole AA. Distinct horizontal patterns in the spatial organization of superficial zone chondrocytes of human joints. Journal of Structural Biology. 162: 335-44. PMID 18325787 DOI: 10.1016/j.jsb.2008.01.010  1
2008 Stevens AL, Wishnok JS, Chai DH, Grodzinsky AJ, Tannenbaum SR. A sodium dodecyl sulfate-polyacrylamide gel electrophoresis-liquid chromatography tandem mass spectrometry analysis of bovine cartilage tissue response to mechanical compression injury and the inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta. Arthritis and Rheumatism. 58: 489-500. PMID 18240213 DOI: 10.1002/art.23120  1
2008 Wagner T, Eden U, Fregni F, Valero-Cabre A, Ramos-Estebanez C, Pronio-Stelluto V, Grodzinsky A, Zahn M, Pascual-Leone A. Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study. Experimental Brain Research. 186: 539-50. PMID 18193208 DOI: 10.1007/s00221-007-1258-8  1
2008 Fitzgerald JB, Jin M, Chai DH, Siparsky P, Fanning P, Grodzinsky AJ. Shear- and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants Journal of Biological Chemistry. 283: 6735-6743. PMID 18086670 DOI: 10.1074/jbc.M708670200  1
2008 Stevens AL, Wheeler CA, Tannenbaum SR, Grodzinsky AJ. Nitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-alpha but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 16: 489-97. PMID 17923423 DOI: 10.1016/j.joca.2007.07.015  1
2007 Han L, Dean D, Mao P, Ortiz C, Grodzinsky AJ. Nanoscale shear deformation mechanisms of opposing cartilage aggrecan macromolecules. Biophysical Journal. 93: L23-5. PMID 17586571 DOI: 10.1529/biophysj.107.114025  1
2007 DiMicco MA, Kisiday JD, Gong H, Grodzinsky AJ. Structure of pericellular matrix around agarose-embedded chondrocytes Osteoarthritis and Cartilage. 15: 1207-1216. PMID 17524677 DOI: 10.1016/j.joca.2007.03.023  1
2007 Han L, Dean D, Ortiz C, Grodzinsky AJ. Lateral nanomechanics of cartilage aggrecan macromolecules. Biophysical Journal. 92: 1384-98. PMID 17142289 DOI: 10.1529/biophysj.106.091397  1
2007 Patwari P, Cheng DM, Cole AA, Kuettner KE, Grodzinsky AJ. Analysis of the relationship between peak stress and proteoglycan loss following injurious compression of human post-mortem knee and ankle cartilage. Biomechanics and Modeling in Mechanobiology. 6: 83-9. PMID 16715319 DOI: 10.1007/s10237-006-0037-y  1
2006 Behera AK, Hildebrand E, Szafranski J, Hung HH, Grodzinsky AJ, Lafyatis R, Koch AE, Kalish R, Perides G, Steere AC, Hu LT. Role of aggrecanase 1 in Lyme arthritis. Arthritis and Rheumatism. 54: 3319-29. PMID 17009305 DOI: 10.1002/art.22128  1
2006 Dean D, Han L, Grodzinsky AJ, Ortiz C. Compressive nanomechanics of opposing aggrecan macromolecules. Journal of Biomechanics. 39: 2555-65. PMID 16289077 DOI: 10.1016/j.jbiomech.2005.09.007  1
2005 Bathe M, Rutledge GC, Grodzinsky AJ, Tidor B. Osmotic pressure of aqueous chondroitin sulfate solution: a molecular modeling investigation. Biophysical Journal. 89: 2357-71. PMID 16055525 DOI: 10.1529/biophysj.105.067918  1
2005 Lee JH, Fitzgerald JB, Dimicco MA, Grodzinsky AJ. Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression. Arthritis and Rheumatism. 52: 2386-95. PMID 16052587 DOI: 10.1002/art.21215  1
2005 Seog J, Dean D, Rolauffs B, Wu T, Genzer J, Plaas AH, Grodzinsky AJ, Ortiz C. Nanomechanics of opposing glycosaminoglycan macromolecules. Journal of Biomechanics. 38: 1789-97. PMID 16023465 DOI: 10.1016/j.jbiomech.2004.09.010  1
2005 Bathe M, Rutledge GC, Grodzinsky AJ, Tidor B. A coarse-grained molecular model for glycosaminoglycans: application to chondroitin, chondroitin sulfate, and hyaluronic acid. Biophysical Journal. 88: 3870-87. PMID 15805173 DOI: 10.1529/biophysj.104.058800  1
2005 Lu Y, Adkisson HD, Bogdanske J, Kalscheur V, Maloney W, Cheung R, Grodzinsky AJ, Hruska KA, Markel MD. In vivo transplantation of neonatal ovine neocartilage allografts: determining the effectiveness of tissue transglutaminase. The Journal of Knee Surgery. 18: 31-42. PMID 15742595  1
2005 Kisiday JD, Kurz B, DiMicco MA, Grodzinsky AJ. Evaluation of medium supplemented with insulin-transferrin-selenium for culture of primary bovine calf chondrocytes in three-dimensional hydrogel scaffolds. Tissue Engineering. 11: 141-51. PMID 15738669 DOI: 10.1089/ten.2005.11.141  1
2004 Bathe M, Grodzinsky AJ, Tidor B, Rutledge GC. Optimal linearized Poisson-Boltzmann theory applied to the simulation of flexible polyelectrolytes in solution. The Journal of Chemical Physics. 121: 7557-61. PMID 15485214 DOI: 10.1063/1.1808411  1
2004 Wagner TA, Zahn M, Grodzinsky AJ, Pascual-Leone A. Three-dimensional head model simulation of transcranial magnetic stimulation. Ieee Transactions On Bio-Medical Engineering. 51: 1586-98. PMID 15376507 DOI: 10.1109/TBME.2004.827925  1
2004 Gouze JN, Stoddart MJ, Gouze E, Palmer GD, Ghivizzani SC, Grodzinsky AJ, Evans CH. In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors. Methods in Molecular Medicine. 100: 147-64. PMID 15280594 DOI: 10.1385/1-59259-810-2:147  1
2004 Kisiday JD, Jin M, DiMicco MA, Kurz B, Grodzinsky AJ. Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds. Journal of Biomechanics. 37: 595-604. PMID 15046988 DOI: 10.1016/j.jbiomech.2003.10.005  1
2004 DiMicco MA, Patwari P, Siparsky PN, Kumar S, Pratta MA, Lark MW, Kim YJ, Grodzinsky AJ. Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury. Arthritis and Rheumatism. 50: 840-8. PMID 15022326 DOI: 10.1002/art.20101  1
2004 Gouze JN, Gouze E, Palmer GD, Kaneto H, Ghivizzani SC, Grodzinsky AJ, Evans CH. Adenovirus-mediated gene transfer of glutamine: Fructose-6-phosphate amidotransferase antagonizes the effects of interluekin-1β on rat chondrocytes Osteoarthritis and Cartilage. 12: 217-224. PMID 14972338 DOI: 10.1016/j.joca.2003.11.002  1
2004 Pufe T, Lemke A, Kurz B, Petersen W, Tillmann B, Grodzinsky AJ, Mentlein R. Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. The American Journal of Pathology. 164: 185-92. PMID 14695332 DOI: 10.1016/S0002-9440(10)63109-4  1
2003 Ng L, Grodzinsky AJ, Patwari P, Sandy J, Plaas A, Ortiz C. Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy. Journal of Structural Biology. 143: 242-57. PMID 14572479  1
2003 Patwari P, Cook MN, DiMicco MA, Blake SM, James IE, Kumar S, Cole AA, Lark MW, Grodzinsky AJ. Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines. Arthritis and Rheumatism. 48: 1292-301. PMID 12746902 DOI: 10.1002/art.10892  1
1976 Grodzinsky AJ, Melcher JR. Electromechanical transduction with charged polyelectrolyte membranes. Ieee Transactions On Bio-Medical Engineering. 23: 421-33. PMID 977010 DOI: 10.1109/TBME.1976.324600  1
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