Manoj T. Duraisingh - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Parasitology Biology, Genetics, Microbiology Biology

158 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Day CJ, Favuzza P, Bielfeld S, Haselhorst T, Seefeldt L, Hauser J, Shewell LK, Flueck C, Poole J, Jen FE, Schäfer A, Dangy JP, Gilberger TW, França CT, Duraisingh MT, et al. The essential malaria protein PfCyRPA targets glycans to invade erythrocytes. Cell Reports. 43: 114012. PMID 38573856 DOI: 10.1016/j.celrep.2024.114012  0.369
2024 Lappalainen R, Kumar M, Duraisingh MT. Hungry for control: metabolite signaling to chromatin in Plasmodium falciparum. Current Opinion in Microbiology. 78: 102430. PMID 38306915 DOI: 10.1016/j.mib.2024.102430  0.366
2023 Obaldía N, Da Silva Filho JL, Núñez M, Glass KA, Oulton T, Achcar F, Wirjanata G, Duraisingh M, Felgner P, Tetteh KK, Bozdech Z, Otto TD, Marti M. Sterile protection against malaria by repeated blood stage infection in the monkey model. Life Science Alliance. 7. PMID 38158220 DOI: 10.26508/lsa.202302524  0.317
2023 Dash R, Skillman KM, Pereira L, Mascarenhas A, Dass S, Walke J, Almeida A, Fernandes M, Gomes E, White J, Chery-Karschney L, Khandeparkar A, Rathod PK, Duraisingh MT, Kanjee U. Development of a Plasmodium vivax biobank for functional ex vivo assays. Malaria Journal. 22: 250. PMID 37653486 DOI: 10.1186/s12936-023-04668-2  0.316
2023 Duraisingh MT, Gubbels MJ, Zarringhalam K. A rising tide of parasite transcriptomics propels pathogen biology. Plos Biology. 21: e3001997. PMID 36696650 DOI: 10.1371/journal.pbio.3001997  0.354
2022 Chakrabarti R, Chery-Karschney L, White J, Mascarenhas A, Skillman KM, Kanjee U, Babar PH, Patrapuvich R, Mohapatra PK, Patankar S, Smith JD, Anvikar A, Valecha N, Rahi M, Duraisingh MT, et al. Diverse Malaria Presentations across National Institutes of Health South Asia International Center for Excellence in Malaria Research Sites in India. The American Journal of Tropical Medicine and Hygiene. 107: 107-117. PMID 36228910 DOI: 10.4269/ajtmh.21-1344  0.307
2022 Scully EJ, Liu W, Li Y, Ndjango JN, Peeters M, Kamenya S, Pusey AE, Lonsdorf EV, Sanz CM, Morgan DB, Piel AK, Stewart FA, Gonder MK, Simmons N, Asiimwe C, ... ... Duraisingh MT, et al. The ecology and epidemiology of malaria parasitism in wild chimpanzee reservoirs. Communications Biology. 5: 1020. PMID 36167977 DOI: 10.1038/s42003-022-03962-0  0.325
2022 Archer NM, Pasvol G, Wilson I, Duraisingh MT. Does Fetal Hemoglobin inhibit the malarial parasite Plasmodium falciparum? American Journal of Hematology. PMID 35834276 DOI: 10.1002/ajh.26661  0.336
2022 Kumar S, Li X, McDew-White M, Reyes A, Delgado E, Sayeed A, Haile MT, Abatiyow BA, Kennedy SY, Camargo N, Checkley LA, Brenneman KV, Button-Simons KA, Duraisingh MT, Cheeseman IH, et al. A Malaria Parasite Cross Reveals Genetic Determinants of Growth in Different Culture Media. Frontiers in Cellular and Infection Microbiology. 12: 878496. PMID 35711667 DOI: 10.3389/fcimb.2022.878496  0.309
2022 Groomes PV, Kanjee U, Duraisingh MT. RBC membrane biomechanics and Plasmodium falciparum invasion: probing beyond ligand-receptor interactions. Trends in Parasitology. PMID 34991983 DOI: 10.1016/j.pt.2021.12.005  0.413
2021 Olivieri A, Lee RS, Fratini F, Keutcha C, Chaand M, Mangano V, Celani F, Mochi S, Birago C, Paone S, Grasso F, Tirelli V, Falchi M, Shabani E, Bertoncini S, ... ... Duraisingh MT, et al. Structural organization of erythrocyte membrane microdomains and their relation with malaria susceptibility. Communications Biology. 4: 1375. PMID 34880413 DOI: 10.1038/s42003-021-02900-w  0.311
2021 Gnangnon B, Duraisingh MT, Buckee CO. Deconstructing the parasite multiplication rate of Plasmodium falciparum. Trends in Parasitology. PMID 34119440 DOI: 10.1016/j.pt.2021.05.001  0.304
2020 Elsworth B, Duraisingh MT. A framework for signaling throughout the life cycle of Babesia species. Molecular Microbiology. PMID 33274587 DOI: 10.1111/mmi.14650  0.311
2020 Kumar M, Skillman K, Duraisingh MT. Linking nutrient sensing and gene expression in Plasmodium falciparum blood-stage parasites. Molecular Microbiology. PMID 33236377 DOI: 10.1111/mmi.14652  0.387
2020 Kanjee U, Grüring C, Babar P, Meyers A, Dash R, Pereira L, Mascarenhas A, Chaand M, Rangel GW, Clark MA, Chery L, Gomes E, Rathod PK, Duraisingh MT. Plasmodium vivax strains use alternative pathways for invasion. The Journal of Infectious Diseases. PMID 32941614 DOI: 10.1093/Infdis/Jiaa592  0.422
2020 Paul AS, Miliu A, Paulo JA, Goldberg JM, Bonilla AM, Berry L, Seveno M, Braun-Breton C, Kosber AL, Elsworth B, Arriola JSN, Lebrun M, Gygi SP, Lamarque MH, Duraisingh MT. Co-option of Plasmodium falciparum PP1 for egress from host erythrocytes. Nature Communications. 11: 3532. PMID 32669539 DOI: 10.1038/S41467-020-17306-1  0.474
2020 Gubbels MJ, Keroack CD, Dangoudoubiyam S, Worliczek HL, Paul AS, Bauwens C, Elsworth B, Engelberg K, Howe DK, Coppens I, Duraisingh MT. Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes. Frontiers in Cellular and Infection Microbiology. 10: 269. PMID 32582569 DOI: 10.3389/Fcimb.2020.00269  0.393
2020 Cai F, DeSimone TM, Hansen E, Jennings CV, Bei AK, Ahouidi AD, Mboup S, Duraisingh MT, Buckee CO. Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains. Plos Computational Biology. 16: e1007702. PMID 32315315 DOI: 10.1371/Journal.Pcbi.1007702  0.825
2020 Rangel GW, Clark MA, Kanjee U, Goldberg JM, MacInnis B, José Menezes M, Ferreira MU, Duraisingh MT. Plasmodium vivax transcriptional profiling of low input cryopreserved isolates through the intraerythrocytic development cycle. Plos Neglected Tropical Diseases. 14: e0008104. PMID 32119669 DOI: 10.1371/Journal.Pntd.0008104  0.398
2020 Cai FY, DeSimone TM, Hansen E, Jennings CV, Bei AK, Ahouidi AD, Mboup S, Duraisingh MT, Buckee CO. Additional modeling details. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007702.S011  0.762
2020 Cai FY, DeSimone TM, Hansen E, Jennings CV, Bei AK, Ahouidi AD, Mboup S, Duraisingh MT, Buckee CO. Distribution of multiplicity used to estimate invasion profile of the Dd2Nm strain. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007702.S005  0.78
2020 Cai FY, DeSimone TM, Hansen E, Jennings CV, Bei AK, Ahouidi AD, Mboup S, Duraisingh MT, Buckee CO. Invasion strategies of field strains. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007702.S004  0.774
2020 Cai FY, DeSimone TM, Hansen E, Jennings CV, Bei AK, Ahouidi AD, Mboup S, Duraisingh MT, Buckee CO. Maximum likelihood estimate of the fraction susceptible fMLE (y-axis) and λMLE (x-axis) for six lab strains, stratified by age of red blood cell fraction. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007702.S003  0.762
2020 Cai FY, DeSimone TM, Hansen E, Jennings CV, Bei AK, Ahouidi AD, Mboup S, Duraisingh MT, Buckee CO. Relative post-invasion parasitemia versus strains. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007702.S002  0.768
2020 Cai FY, DeSimone TM, Hansen E, Jennings CV, Bei AK, Ahouidi AD, Mboup S, Duraisingh MT, Buckee CO. Comparison of Poisson and zero-inflated Poisson model fits. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007702.S001  0.79
2019 Proto WR, Siegel SV, Dankwa S, Liu W, Kemp A, Marsden S, Zenonos ZA, Unwin S, Sharp PM, Wright GJ, Hahn BH, Duraisingh MT, Rayner JC. Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand. Nature Communications. 10: 4512. PMID 31586047 DOI: 10.1038/S41467-019-12294-3  0.482
2019 Scully EJ, Shabani E, Rangel GW, Grüring C, Kanjee U, Clark MA, Chaand M, Kurita R, Nakamura Y, Ferreira MU, Duraisingh MT. Generation of an immortalized erythroid progenitor cell line from peripheral blood: a model system for the functional analysis of Plasmodium spp. invasion. American Journal of Hematology. PMID 31148215 DOI: 10.1002/Ajh.25543  0.466
2019 Elsworth B, Keroack CD, Duraisingh MT. Elucidating Host Cell Uptake by Malaria Parasites. Trends in Parasitology. PMID 31003757 DOI: 10.1016/J.Pt.2019.03.005  0.439
2019 Archer NM, Duraisingh M. Fetal Hemoglobin Promotes P. Falciparum Growth in Sickle Cell Disease Erythrocytes Blood. 134: 2252-2252. DOI: 10.1182/Blood-2019-130763  0.428
2018 Keroack CD, Elsworth B, Duraisingh MT. To kill a piroplasm: genetic technologies to advance drug discovery and target identification in Babesia. International Journal For Parasitology. PMID 30391230 DOI: 10.1016/J.Ijpara.2018.09.005  0.434
2018 Kanjee U, Rangel GW, Clark MA, Duraisingh MT. Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes. Current Opinion in Microbiology. 46: 109-115. PMID 30366310 DOI: 10.1016/J.Mib.2018.10.002  0.461
2018 Egan ES, Weekes MP, Kanjee U, Manzo J, Srinivasan A, Lomas-Francis C, Westhoff C, Takahashi J, Tanaka M, Watanabe S, Brugnara C, Gygi SP, Tani Y, Duraisingh MT. Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite . Communications Biology. 1: 45. PMID 30271928 DOI: 10.1038/s42003-018-0046-2  0.378
2018 Archer NM, Petersen N, Clark MA, Buckee CO, Childs LM, Duraisingh MT. Resistance to in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition. Proceedings of the National Academy of Sciences of the United States of America. PMID 29946035 DOI: 10.1073/Pnas.1804388115  0.416
2018 Duraisingh MT, Skillman KM. Epigenetic Variation and Regulation in Malaria Parasites. Annual Review of Microbiology. PMID 29927705 DOI: 10.1146/Annurev-Micro-090817-062722  0.483
2018 Obaldia N, Meibalan E, Sa JM, Ma S, Clark MA, Mejia P, Moraes Barros RR, Otero W, Ferreira MU, Mitchell JR, Milner DA, Huttenhower C, Wirth DF, Duraisingh MT, Wellems TE, et al. Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection. Mbio. 9. PMID 29739900 DOI: 10.1128/Mbio.00625-18  0.401
2018 Rangel GW, Clark MA, Kanjee U, Lim C, Shaw-Saliba K, Menezes MJ, Mascarenhas A, Chery L, Gomes E, Rathod PK, Ferreira MU, Duraisingh MT. Enhanced ex vivo Plasmodium vivax intraerythrocytic enrichment and maturation for rapid and sensitive parasite growth assays. Antimicrobial Agents and Chemotherapy. PMID 29378713 DOI: 10.1128/Aac.02519-17  0.416
2018 Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, ... ... Duraisingh MT, et al. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science (New York, N.Y.). 359: 48-55. PMID 29302006 DOI: 10.1126/Science.Aan1078  0.429
2018 Wong W, Huang R, Menant S, Hong C, Sandow JJ, Birkinshaw RW, Healer J, Hodder AN, Kanjee U, Tonkin CJ, Heckmann D, Soroka V, Søgaard TMM, Jørgensen T, Duraisingh MT, et al. Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex. Nature. 565: 118-121. DOI: 10.2210/Pdb6Mpv/Pdb  0.4
2018 Archer NM, Petersen N, Hankins JS, Duraisingh MT. Reduced Plasmodium Falciparum Growth in Erythrocytes Is Associated with Fetal Hemoglobin Expression Blood. 132: 1067-1067. DOI: 10.1182/Blood-2018-99-117857  0.399
2018 Rosanwo TO, Kinney M, Clark MA, Vo LT, Rowe RG, Archer NM, Heeney MM, Schlaeger T, Bauer DE, Fleming MD, Duraisingh MT, Orkin SH, Brugnara C, North T, Daley GQ. Optimized Beta-Globin Expression and Enucleation from Induced Red Blood Cells for In Vitro Modeling of Sickle Cell Disease Blood. 132: 2359-2359. DOI: 10.1182/Blood-2018-99-114136  0.307
2017 Paul AS, Duraisingh MT. Targeting Plasmodium Proteases to Block Malaria Parasite Escape and Entry. Trends in Parasitology. PMID 29269028 DOI: 10.1016/J.Pt.2017.11.012  0.498
2017 Patankar S, Sharma S, Rathod PK, Duraisingh M. Malaria in India: The Need for New Targets for Diagnosis And Detection of Plasmodium vivax. Proteomics. Clinical Applications. PMID 29193853 DOI: 10.1002/Prca.201700024  0.416
2017 Brancucci NMB, Gerdt JP, Wang C, De Niz M, Philip N, Adapa SR, Zhang M, Hitz E, Niederwieser I, Boltryk SD, Laffitte MC, Clark MA, Grüring C, Ravel D, Blancke Soares A, ... ... Duraisingh MT, et al. Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum. Cell. PMID 29129376 DOI: 10.1016/J.Cell.2017.10.020  0.421
2017 Scully EJ, Kanjee U, Duraisingh MT. Molecular interactions governing host-specificity of blood stage malaria parasites. Current Opinion in Microbiology. 40: 21-31. PMID 29096194 DOI: 10.1016/J.Mib.2017.10.006  0.512
2017 Kanjee U, Grüring C, Chaand M, Lin KM, Egan E, Manzo J, Jones PL, Yu T, Barker R, Weekes MP, Duraisingh MT. CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants of Plasmodium falciparum invasion. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078358 DOI: 10.1073/Pnas.1711310114  0.49
2017 Cowman AF, Tonkin CJ, Tham WH, Duraisingh MT. The Molecular Basis of Erythrocyte Invasion by Malaria Parasites. Cell Host & Microbe. 22: 232-245. PMID 28799908 DOI: 10.1016/J.Chom.2017.07.003  0.461
2017 Dankwa S, Chaand M, Kanjee U, Jiang RHY, Nobre LV, Goldberg JM, Bei AK, Moechtar MA, Grüring C, Ahouidi AD, Ndiaye D, Dieye TN, Mboup S, Weekes MP, Duraisingh MT. Genetic evidence for erythrocyte receptor glycophorin B expression levels defining a dominant Plasmodium falciparum invasion pathway into human erythrocytes. Infection and Immunity. PMID 28760933 DOI: 10.1128/Iai.00074-17  0.725
2017 Kumar S, Kumar M, Ekka R, Dvorin JD, Paul AS, Madugundu AK, Gilberger T, Gowda H, Duraisingh MT, Keshava Prasad TS, Sharma P. PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum. Nature Communications. 8: 63. PMID 28680058 DOI: 10.1038/S41467-017-00053-1  0.4
2017 Bei AK, Ahouidi AD, Dvorin JD, Miura K, Diouf A, Ndiaye D, Premji Z, Diakite M, Mboup S, Long CA, Duraisingh MT. Functional analysis reveals geographical variation in inhibitory immune responses against a polymorphic malaria antigen. The Journal of Infectious Diseases. PMID 28605544 DOI: 10.1093/Infdis/Jix280  0.673
2017 Lim C, Dankwa S, Paul AS, Duraisingh MT. Host Cell Tropism and Adaptation of Blood-Stage Malaria Parasites: Challenges for Malaria Elimination. Cold Spring Harbor Perspectives in Medicine. PMID 28213436 DOI: 10.1101/Cshperspect.A025494  0.477
2017 Ganter M, Goldberg JM, Dvorin JD, Paulo JA, King JG, Tripathi AK, Paul AS, Yang J, Coppens I, Jiang RH, Elsworth B, Baker DA, Dinglasan RR, Gygi SP, Duraisingh MT. Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nature Microbiology. 2: 17017. PMID 28211852 DOI: 10.1038/Nmicrobiol.2017.17  0.37
2016 Chery L, Maki JN, Mascarenhas A, Walke JT, Gawas P, Almeida A, Fernandes M, Vaz M, Ramanan R, Shirodkar D, Bernabeu M, Manoharan SK, Pereira L, Dash R, Sharma A, ... ... Duraisingh MT, et al. Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India. Malaria Journal. 15: 569. PMID 27884146 DOI: 10.1186/S12936-016-1619-5  0.381
2016 Hostetler JB, Lo E, Kanjee U, Amaratunga C, Suon S, Sreng S, Mao S, Yewhalaw D, Mascarenhas A, Kwiatkowski DP, Ferreira MU, Rathod PK, Yan G, Fairhurst RM, Duraisingh MT, et al. Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications. Plos Neglected Tropical Diseases. 10: e0005091. PMID 27798646 DOI: 10.1371/Journal.Pntd.0005091  0.468
2016 Mantel PY, Hjelmqvist D, Walch M, Kharoubi-Hess S, Nilsson S, Ravel D, Ribeiro M, Grüring C, Ma S, Padmanabhan P, Trachtenberg A, Ankarklev J, Brancucci NM, Huttenhower C, Duraisingh MT, et al. Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria. Nature Communications. 7: 12727. PMID 27721445 DOI: 10.1038/Ncomms12727  0.392
2016 Shaw-Saliba K, Thomson-Luque R, Obaldía N, Nuñez M, Dutary S, Lim C, Barnes S, Kocken CH, Duraisingh MT, Adams JH, Pasini EM. Insights into an Optimization of Plasmodium vivax Sal-1 In Vitro Culture: The Aotus Primate Model. Plos Neglected Tropical Diseases. 10: e0004870. PMID 27463518 DOI: 10.1371/Journal.Pntd.0004870  0.423
2016 Kumar S, Mudeppa D, Sharma A, Mascarenhas A, Dash R, Pereira L, Shaik RB, Maki JN, White J, Zuo W, Tuljapurkar S, Duraisingh MT, Gomes E, Chery L, Rathod PK. Distinct genomic architecture of Plasmodium falciparum populations from South Asia. Molecular and Biochemical Parasitology. PMID 27457272 DOI: 10.1016/J.Molbiopara.2016.07.005  0.368
2016 Shaw-Saliba K, Clarke D, Santos JM, Menezes MJ, Lim C, Mascarenhas A, Chery L, Gomes E, March S, Bhatia SN, Rathod PK, Ferreira MU, Catteruccia F, Duraisingh MT. Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates. International Journal For Parasitology. PMID 27456552 DOI: 10.1016/J.Ijpara.2016.06.003  0.443
2016 Lim C, Pereira L, Saliba KS, Macarenhas A, Maki J, Chery L, Gomes E, Rathod PK, Duraisingh MT. Brief Report: Reticulocyte preference and stage development of Plasmodium vivax isolates. The Journal of Infectious Diseases. PMID 27432121 DOI: 10.1093/Infdis/Jiw303  0.425
2016 Paul AS, Moreira CK, Elsworth B, Allred DR, Duraisingh MT. Extensive shared chemosensitivity between malaria and babesiosis blood-stage parasites. Antimicrobial Agents and Chemotherapy. PMID 27246780 DOI: 10.1128/Aac.00928-16  0.46
2016 Duraisingh MT, Horn D. Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa. Cell Host & Microbe. 19: 629-40. PMID 27173931 DOI: 10.1016/J.Chom.2016.04.020  0.466
2016 Dankwa S, Lim C, Bei AK, Jiang RH, Abshire JR, Patel SD, Goldberg JM, Moreno Y, Kono M, Niles JC, Duraisingh MT. Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite. Nature Communications. 7: 11187. PMID 27041489 DOI: 10.1038/Ncomms11187  0.713
2016 Joice R, Frantzreb C, Pradham A, Seydel KB, Kamiza S, Wirth DF, Duraisingh MT, Molyneux ME, Taylor TE, Marti M, Milner DA. Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. PMID 26916076 DOI: 10.1038/Modpathol.2016.27  0.308
2016 Obaldía Iii N, Dow GS, Gerena L, Kyle D, Otero W, Mantel PY, Baro N, Daniels R, Mukherjee A, Childs LM, Buckee C, Duraisingh MT, Volkman SK, Wirth DF, Marti M. Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model. Scientific Reports. 6: 21216. PMID 26880111 DOI: 10.1038/Srep21216  0.437
2015 Ahouidi AD, Amambua-Ngwa A, Awandare GA, Bei AK, Conway DJ, Diakite M, Duraisingh MT, Rayner JC, Zenonos ZA. Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN). Trends in Parasitology. PMID 26725306 DOI: 10.1016/J.Pt.2015.11.009  0.681
2015 Tubman VN, Mejia P, Shmukler BE, Bei AK, Alper SL, Mitchell JR, Brugnara C, Duraisingh MT. The clinically tested Gardos channel inhibitor, senicapoc, exhibits antimalarial activity. Antimicrobial Agents and Chemotherapy. PMID 26459896 DOI: 10.1128/Aac.01668-15  0.637
2015 Bei AK, Duraisingh MT. Measuring Plasmodium falciparum Erythrocyte Invasion Phenotypes Using Flow Cytometry. Methods in Molecular Biology (Clifton, N.J.). 1325: 167-86. PMID 26450388 DOI: 10.1007/978-1-4939-2815-6_14  0.697
2015 Assefa S, Lim C, Preston MD, Duffy CW, Nair MB, Adroub SA, Kadir KA, Goldberg JM, Neafsey DE, Divis P, Clark TG, Duraisingh MT, Conway DJ, Pain A, Singh B. Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi. Proceedings of the National Academy of Sciences of the United States of America. PMID 26438871 DOI: 10.1073/Pnas.1509534112  0.373
2015 Wassmer SC, Taylor TE, Rathod PK, Mishra SK, Mohanty S, Arevalo-Herrera M, Duraisingh MT, Smith JD. Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach. The American Journal of Tropical Medicine and Hygiene. 93: 42-56. PMID 26259939 DOI: 10.4269/Ajtmh.14-0841  0.447
2015 Paul AS, Saha S, Engelberg K, Jiang RH, Coleman BI, Kosber AL, Chen CT, Ganter M, Espy N, Gilberger TW, Gubbels MJ, Duraisingh MT. Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans. Cell Host & Microbe. PMID 26118996 DOI: 10.1016/J.Chom.2015.06.003  0.79
2015 Egan ES, Jiang RH, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C, Tani Y, Takahashi J, Watanabe S, Goldberg J, Paul AS, Brugnara C, ... ... Duraisingh MT, et al. Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion. Science (New York, N.Y.). 348: 711-4. PMID 25954012 DOI: 10.1126/Science.Aaa3526  0.435
2015 Merrick CJ, Jiang RH, Skillman KM, Samarakoon U, Moore RM, Dzikowski R, Ferdig MT, Duraisingh MT. Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains. Plos One. 10: e0118865. PMID 25780929 DOI: 10.1371/Journal.Pone.0118865  0.382
2015 Paul AS, Egan ES, Duraisingh MT. Host-parasite interactions that guide red blood cell invasion by malaria parasites. Current Opinion in Hematology. 22: 220-6. PMID 25767956 DOI: 10.1097/Moh.0000000000000135  0.49
2015 Mejia P, Treviño-Villarreal JH, Hine C, Harputlugil E, Lang S, Calay E, Rogers R, Wirth D, Duraisingh MT, Mitchell JR. Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression. Nature Communications. 6: 6050. PMID 25636003 DOI: 10.1038/Ncomms7050  0.406
2015 Kumar AA, Lim C, Moreno Y, Mace CR, Syed A, Van Tyne D, Wirth DF, Duraisingh MT, Whitesides GM. Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers. American Journal of Hematology. 90: 31-6. PMID 25263455 DOI: 10.1002/Ajh.23860  0.408
2014 Coleman BI, Skillman KM, Jiang RH, Childs LM, Altenhofen LM, Ganter M, Leung Y, Goldowitz I, Kafsack BF, Marti M, Llinás M, Buckee CO, Duraisingh MT. A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion. Cell Host & Microbe. 16: 177-86. PMID 25121747 DOI: 10.1016/J.Chom.2014.06.014  0.775
2014 Guillén N, Duraisingh M. Editorial overview: Host-microbe interactions: parasites: sensing and responding to the changing environment: the life of protozoan parasites. Current Opinion in Microbiology. 20: vii-ix. PMID 25081632 DOI: 10.1016/J.Mib.2014.07.003  0.404
2014 Niang M, Bei AK, Madnani KG, Pelly S, Dankwa S, Kanjee U, Gunalan K, Amaladoss A, Yeo KP, Bob NS, Malleret B, Duraisingh MT, Preiser PR. STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting. Cell Host & Microbe. 16: 81-93. PMID 25011110 DOI: 10.1016/J.Chom.2014.06.004  0.72
2014 Joice R, Nilsson SK, Montgomery J, Dankwa S, Egan E, Morahan B, Seydel KB, Bertuccini L, Alano P, Williamson KC, Duraisingh MT, Taylor TE, Milner DA, Marti M. Plasmodium falciparum transmission stages accumulate in the human bone marrow. Science Translational Medicine. 6: 244re5. PMID 25009232 DOI: 10.1126/Scitranslmed.3008882  0.415
2014 Grüring C, Moon RW, Lim C, Holder AA, Blackman MJ, Duraisingh MT. Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research. Cellular Microbiology. 16: 612-20. PMID 24506567 DOI: 10.1111/Cmi.12275  0.486
2014 Tubman VN, Mejia P, Shmukler BE, Alper SL, Mitchell JR, Brugnara C, Duraisingh MT. Senicapoc, a Gardos Channel Inhibitor Developed to Treat Sickle Cell Disease, Exhibits Antimalarial Activity Blood. 124: 743-743. DOI: 10.1182/Blood.V124.21.743.743  0.426
2013 Patel SD, Ahouidi AD, Bei AK, Dieye TN, Mboup S, Harrison SC, Duraisingh MT. Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans. The Journal of Infectious Diseases. 208: 1679-87. PMID 23904294 DOI: 10.1093/Infdis/Jit385  0.694
2013 Badiane AS, Bei AK, Ahouidi AD, Patel SD, Salinas N, Ndiaye D, Sarr O, Ndir O, Tolia NH, Mboup S, Duraisingh MT. Inhibitory humoral responses to the Plasmodium falciparum vaccine candidate EBA-175 are independent of the erythrocyte invasion pathway. Clinical and Vaccine Immunology : Cvi. 20: 1238-45. PMID 23761656 DOI: 10.1128/Cvi.00135-13  0.722
2013 Engelberg K, Paul AS, Prinz B, Kono M, Ching W, Heincke D, Dobner T, Spielmann T, Duraisingh MT, Gilberger TW. Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum. The Biochemical Journal. 452: 457-66. PMID 23544851 DOI: 10.1042/Bj20121694  0.382
2013 Lim C, Hansen E, DeSimone TM, Moreno Y, Junker K, Bei A, Brugnara C, Buckee CO, Duraisingh MT. Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans. Nature Communications. 4: 1638. PMID 23535659 DOI: 10.1038/Ncomms2612  0.82
2012 Coleman BI, Ribacke U, Manary M, Bei AK, Winzeler EA, Wirth DF, Duraisingh MT. Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. Cell Host & Microbe. 12: 739-50. PMID 23245319 DOI: 10.1016/J.Chom.2012.11.004  0.798
2012 Badiane AS, Sarr O, Deme AB, Ahouidi AD, Gueye PE, Ndiaye M, Seck MC, Diallo M, Bei AK, Duraisingh MT, Wirth D, Ndiaye D, Ndir O, Mboup S. Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal. Journal of Infection in Developing Countries. 6: 727-33. PMID 23103895 DOI: 10.3855/Jidc.2587  0.654
2012 Gubbels MJ, Duraisingh MT. Evolution of apicomplexan secretory organelles. International Journal For Parasitology. 42: 1071-81. PMID 23068912 DOI: 10.1016/J.Ijpara.2012.09.009  0.406
2012 Vorobjev IA, Buchholz K, Prabhat P, Ketman K, Egan ES, Marti M, Duraisingh MT, Barteneva NS. Optimization of flow cytometric detection and cell sorting of transgenic Plasmodium parasites using interchangeable optical filters. Malaria Journal. 11: 312. PMID 22950515 DOI: 10.1186/1475-2875-11-312  0.383
2012 Duraisingh MT, Lodish HF. Sickle cell microRNAs inhibit the malaria parasite. Cell Host & Microbe. 12: 127-8. PMID 22901533 DOI: 10.1016/J.Chom.2012.08.001  0.453
2012 Bei AK, Duraisingh MT. Functional analysis of erythrocyte determinants of Plasmodium infection. International Journal For Parasitology. 42: 575-82. PMID 22726752 DOI: 10.1016/J.Ijpara.2012.03.006  0.715
2012 Merrick CJ, Huttenhower C, Buckee C, Amambua-Ngwa A, Gomez-Escobar N, Walther M, Conway DJ, Duraisingh MT. Epigenetic dysregulation of virulence gene expression in severe Plasmodium falciparum malaria. The Journal of Infectious Diseases. 205: 1593-600. PMID 22448008 DOI: 10.1093/Infdis/Jis239  0.483
2012 Narayanasamy K, Chery L, Basu A, Duraisingh MT, Escalante A, Fowble J, Guler JL, Herricks T, Kumar A, Majumder P, Maki J, Mascarenhas A, Rodrigues J, Roy B, Sen S, et al. Malaria evolution in South Asia: knowledge for control and elimination. Acta Tropica. 121: 256-66. PMID 22266213 DOI: 10.1016/J.Actatropica.2012.01.008  0.405
2012 Farrell A, Thirugnanam S, Lorestani A, Dvorin JD, Eidell KP, Ferguson DJ, Anderson-White BR, Duraisingh MT, Marth GT, Gubbels MJ. A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis. Science (New York, N.Y.). 335: 218-21. PMID 22246776 DOI: 10.1126/Science.1210829  0.403
2012 Doumbia SO, Ndiaye D, Koita OA, Diakité M, Nwakanma D, Coulibaly M, Traoré SF, Keating J, Milner DA, Ndiaye JL, Sene PD, Ahouidi A, Dieye TN, Gaye O, Okebe J, ... ... Duraisingh M, et al. Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Tropica. 121: 175-83. PMID 22142790 DOI: 10.1016/J.Actatropica.2011.11.009  0.658
2012 Ceesay SJ, Bojang KA, Nwakanma D, Conway DJ, Koita OA, Doumbia SO, Ndiaye D, Coulibaly TF, Diakité M, Traoré SF, Coulibaly M, Ndiaye JL, Sarr O, Gaye O, Konaté L, ... ... Duraisingh M, et al. Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Tropica. 121: 166-74. PMID 22119584 DOI: 10.1016/J.Actatropica.2011.11.005  0.393
2011 Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH, Dvorin JD, ... Duraisingh MT, et al. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chemistry & Biology. 18: 1602-10. PMID 22195562 DOI: 10.1016/J.Chembiol.2011.09.016  0.754
2011 Crosnier C, Bustamante LY, Bartholdson SJ, Bei AK, Theron M, Uchikawa M, Mboup S, Ndir O, Kwiatkowski DP, Duraisingh MT, Rayner JC, Wright GJ. Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature. 480: 534-7. PMID 22080952 DOI: 10.1038/nature10606  0.709
2011 Broadbent KM, Park D, Wolf AR, Van Tyne D, Sims JS, Ribacke U, Volkman S, Duraisingh M, Wirth D, Sabeti PC, Rinn JL. A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biology. 12: R56. PMID 21689454 DOI: 10.1186/Gb-2011-12-6-R56  0.34
2011 Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, ... ... Duraisingh M, et al. Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 55: 2612-22. PMID 21422215 DOI: 10.1128/Aac.01714-10  0.728
2011 Comeaux CA, Coleman BI, Bei AK, Whitehurst N, Duraisingh MT. Functional analysis of epigenetic regulation of tandem RhopH1/clag genes reveals a role in Plasmodium falciparum growth. Molecular Microbiology. 80: 378-90. PMID 21320181 DOI: 10.1111/J.1365-2958.2011.07572.X  0.797
2011 Amino R, Bassat Q, Baum J, Billker O, Bogyo M, Bousema T, Christophides G, Deitsch K, Dinglasan R, Djimde A, Duraisingh M, Dzinjalamala F, Happi C, Heussler V, Kramarik J, et al. A research agenda for malaria eradication: basic science and enabling technologies Plos Medicine. 8: 1-6. PMID 21311584 DOI: 10.1371/Journal.Pmed.1000399  0.418
2010 Bei AK, Brugnara C, Duraisingh MT. In vitro genetic analysis of an erythrocyte determinant of malaria infection. The Journal of Infectious Diseases. 202: 1722-7. PMID 20958212 DOI: 10.1086/657157  0.745
2010 Booker ML, Bastos CM, Kramer ML, Barker RH, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jiménez-Díaz MB, Viera S, ... ... Duraisingh M, et al. Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. The Journal of Biological Chemistry. 285: 33054-64. PMID 20702404 DOI: 10.1074/Jbc.M110.162081  0.761
2010 Merrick CJ, Duraisingh MT. Epigenetics in Plasmodium: what do we really know? Eukaryotic Cell. 9: 1150-8. PMID 20562224 DOI: 10.1128/Ec.00093-10  0.467
2010 Dvorin JD, Bei AK, Coleman BI, Duraisingh MT. Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain. Molecular Microbiology. 75: 990-1006. PMID 20487292 DOI: 10.1111/J.1365-2958.2009.07040.X  0.811
2010 Dvorin JD, Martyn DC, Patel SD, Grimley JS, Collins CR, Hopp CS, Bright AT, Westenberger S, Winzeler E, Blackman MJ, Baker DA, Wandless TJ, Duraisingh MT. A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science (New York, N.Y.). 328: 910-2. PMID 20466936 DOI: 10.1126/Science.1188191  0.463
2010 Bei AK, Desimone TM, Badiane AS, Ahouidi AD, Dieye T, Ndiaye D, Sarr O, Ndir O, Mboup S, Duraisingh MT. A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium falciparum. American Journal of Hematology. 85: 234-7. PMID 20196166 DOI: 10.1002/Ajh.21642  0.819
2010 Artavanis-Tsakonas K, Weihofen WA, Antos JM, Coleman BI, Comeaux CA, Duraisingh MT, Gaudet R, Ploegh HL. Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. The Journal of Biological Chemistry. 285: 6857-66. PMID 20042598 DOI: 10.1074/Jbc.M109.072405  0.788
2010 Ahouidi AD, Bei AK, Neafsey DE, Sarr O, Volkman S, Milner D, Cox-Singh J, Ferreira MU, Ndir O, Premji Z, Mboup S, Duraisingh MT. Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 10: 200-6. PMID 19931645 DOI: 10.1016/J.Meegid.2009.11.008  0.686
2010 Merrick CJ, Dzikowski R, Imamura H, Chuang J, Deitsch K, Duraisingh MT. The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes. International Journal For Parasitology. 40: 35-43. PMID 19666023 DOI: 10.1016/J.Ijpara.2009.06.012  0.449
2009 Tonkin CJ, Carret CK, Duraisingh MT, Voss TS, Ralph SA, Hommel M, Duffy MF, Silva LM, Scherf A, Ivens A, Speed TP, Beeson JG, Cowman AF. Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. Plos Biology. 7: e84. PMID 19402747 DOI: 10.1371/Journal.Pbio.1000084  0.468
2009 DeSimone TM, Jennings CV, Bei AK, Comeaux C, Coleman BI, Refour P, Triglia T, Stubbs J, Cowman AF, Duraisingh MT. Cooperativity between Plasmodium falciparum adhesive proteins for invasion into erythrocytes. Molecular Microbiology. 72: 578-89. PMID 19400777 DOI: 10.1111/J.1365-2958.2009.06667.X  0.787
2009 Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. Journal of Medicinal Chemistry. 52: 2185-7. PMID 19317450 DOI: 10.1021/Jm801654Y  0.755
2009 Lantos PM, Ahouidi AD, Bei AK, Jennings CV, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT. Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum. Parasitology. 136: 1-9. PMID 19126266 DOI: 10.1017/S0031182008005167  0.73
2009 Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF. Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 972-5. PMID 19097788 DOI: 10.1016/J.Bmcl.2008.11.071  0.317
2009 DeSimone TM, Bei AK, Jennings CV, Duraisingh MT. Genetic analysis of the cytoplasmic domain of the PfRh2b merozoite invasion protein of Plasmodium falciparum. International Journal For Parasitology. 39: 399-405. PMID 18831976 DOI: 10.1016/J.Ijpara.2008.08.008  0.802
2008 Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. The Journal of Biological Chemistry. 283: 35078-85. PMID 18842591 DOI: 10.1074/Jbc.M804990200  0.437
2008 Coleman BI, Duraisingh MT. Transcriptional control and gene silencing in Plasmodium falciparum. Cellular Microbiology. 10: 1935-46. PMID 18637022 DOI: 10.1111/J.1462-5822.2008.01203.X  0.764
2008 Duraisingh MT, DeSimone T, Jennings C, Refour P, Wu C. Erythrocyte invasion by Plasmodium falciparum: multiple ligand-receptor interactions and phenotypic switching. Sub-Cellular Biochemistry. 47: 46-57. PMID 18512340 DOI: 10.1007/978-0-387-78267-6_3  0.83
2008 Zhou Y, Ramachandran V, Kumar KA, Westenberger S, Refour P, Zhou B, Li F, Young JA, Chen K, Plouffe D, Henson K, Nussenzweig V, Carlton J, Vinetz JM, Duraisingh MT, et al. Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. Plos One. 3: e1570. PMID 18270564 DOI: 10.1371/Journal.Pone.0001570  0.48
2008 Militello KT, Refour P, Comeaux CA, Duraisingh MT. Antisense RNA and RNAi in protozoan parasites: working hard or hardly working? Molecular and Biochemical Parasitology. 157: 117-26. PMID 18053590 DOI: 10.1016/J.Molbiopara.2007.10.004  0.753
2007 Comeaux CA, Duraisingh MT. Unravelling a histone code for malaria virulence. Molecular Microbiology. 66: 1291-5. PMID 18028316 DOI: 10.1111/J.1365-2958.2007.06038.X  0.767
2007 Merrick CJ, Duraisingh MT. Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity. Eukaryotic Cell. 6: 2081-91. PMID 17827348 DOI: 10.1128/Ec.00114-07  0.397
2007 Jennings CV, Ahouidi AD, Zilversmit M, Bei AK, Rayner J, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT. Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal Infection and Immunity. 75: 3531-3538. PMID 17470537 DOI: 10.1128/Iai.00122-07  0.729
2007 Bei AK, Membi CD, Rayner JC, Mubi M, Ngasala B, Sultan AA, Premji Z, Duraisingh MT. Variant merozoite protein expression is associated with erythrocyte invasion phenotypes in Plasmodium falciparum isolates from Tanzania. Molecular and Biochemical Parasitology. 153: 66-71. PMID 17303262 DOI: 10.1016/J.Molbiopara.2007.01.007  0.752
2007 Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, et al. A genome-wide map of diversity in Plasmodium falciparum. Nature Genetics. 39: 113-9. PMID 17159979 DOI: 10.1038/Ng1930  0.445
2007 Bei AK, Membi CD, Rayner JC, Mubi M, Ngasala B, Sultan AA, Premji Z, Duraisingh MT. Erratum to “Variant merozoite protein expression is associated with erythrocyte invasion phenotypes in Plasmodium falciparum isolates from Tanzania” [Mol. Biochem. Parasitol. 149 (2006) 208–215] Molecular and Biochemical Parasitology. 154: 195. DOI: 10.1016/J.Molbiopara.2007.05.006  0.677
2006 Merrick CJ, Duraisingh MT. Heterochromatin-mediated control of virulence gene expression. Molecular Microbiology. 62: 612-20. PMID 17076663 DOI: 10.1111/J.1365-2958.2006.05397.X  0.332
2006 Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT, Ploegh HL. Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum Molecular Microbiology. 61: 1187-1195. PMID 16925553 DOI: 10.1111/J.1365-2958.2006.05307.X  0.774
2005 Stubbs J, Simpson KM, Triglia T, Plouffe D, Tonkin CJ, Duraisingh MT, Maier AG, Winzeler EA, Cowman AF. Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science (New York, N.Y.). 309: 1384-7. PMID 16123303 DOI: 10.1126/Science.1115257  0.497
2005 Duraisingh MT, Refour P. Multiple drug resistance genes in malaria -- from epistasis to epidemiology. Molecular Microbiology. 57: 874-7. PMID 16091030 DOI: 10.1111/J.1365-2958.2005.04748.X  0.34
2005 Duraisingh MT, Voss TS, Marty AJ, Duffy MF, Good RT, Thompson JK, Freitas-Junior LH, Scherf A, Crabb BS, Cowman AF. Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell. 121: 13-24. PMID 15820675 DOI: 10.1016/J.Cell.2005.01.036  0.378
2005 Triglia T, Duraisingh MT, Good RT, Cowman AF. Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum. Molecular Microbiology. 55: 162-74. PMID 15612925 DOI: 10.1111/J.1365-2958.2004.04388.X  0.514
2003 Duraisingh MT, Maier AG, Triglia T, Cowman AF. Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways. Proceedings of the National Academy of Sciences of the United States of America. 100: 4796-801. PMID 12672957 DOI: 10.1073/Pnas.0730883100  0.461
2003 Duraisingh MT, Triglia T, Ralph SA, Rayner JC, Barnwell JW, McFadden GI, Cowman AF. Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes. The Embo Journal. 22: 1047-57. PMID 12606570 DOI: 10.1093/Emboj/Cdg096  0.488
2003 Gilberger TW, Thompson JK, Triglia T, Good RT, Duraisingh MT, Cowman AF. A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes. The Journal of Biological Chemistry. 278: 14480-6. PMID 12556470 DOI: 10.1074/Jbc.M211446200  0.464
2003 Sutherland CJ, Alloueche A, Curtis J, Drakeley CJ, Ord R, Duraisingh M, Greenwood BM, Pinder M, Warhurst D, Targett GA. Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes. The American Journal of Tropical Medicine and Hygiene. 67: 578-85. PMID 12518847 DOI: 10.4269/Ajtmh.2002.67.578  0.348
2003 Maier AG, Duraisingh MT, Reeder JC, Patel SS, Kazura JW, Zimmerman PA, Cowman AF. Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations. Nature Medicine. 9: 87-92. PMID 12469115 DOI: 10.1038/Nm807  0.46
2002 Baldi DL, Good R, Duraisingh MT, Crabb BS, Cowman AF. Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum. Infection and Immunity. 70: 5236-45. PMID 12183575 DOI: 10.1128/Iai.70.9.5236-5245.2002  0.37
2002 Sangster N, Batterham P, Chapman HD, Duraisingh M, Le Jambre L, Shirley M, Upcroft J, Upcroft P. Resistance to antiparasitic drugs: the role of molecular diagnosis. International Journal For Parasitology. 32: 637-53. PMID 11943235 DOI: 10.1016/S0020-7519(01)00365-4  0.357
2002 O'Donnell RA, Freitas-Junior LH, Preiser PR, Williamson DH, Duraisingh M, McElwain TF, Scherf A, Cowman AF, Crabb BS. A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes. The Embo Journal. 21: 1231-9. PMID 11867551 DOI: 10.1093/Emboj/21.5.1231  0.362
2002 Cowman AF, Baldi DL, Duraisingh M, Healer J, Mills KE, O'Donnell RA, Thompson J, Triglia T, Wickham ME, Crabb BS. Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 357: 25-33. PMID 11839179 DOI: 10.1098/Rstb.2001.1010  0.402
2002 Duraisingh MT, Triglia T, Cowman AF. Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination. International Journal For Parasitology. 32: 81-9. PMID 11796125 DOI: 10.1016/S0020-7519(01)00345-9  0.402
2002 Cowman AF, Duraisingh M, O'Donnell RA, Triglia T, Crabb BS. Functional analysis of the Plasmodium falciparum genome using transfection Methods in Microbiology. 33: 383-396. DOI: 10.1016/S0580-9517(02)33021-6  0.47
2001 Warhurst DC, Duraisingh MT. Rational use of drugs against Plasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene. 95: 345-6. PMID 11579870 DOI: 10.1016/S0035-9203(01)90177-4  0.316
2001 Cowman AF, Duraisingh MT. An old enemy, a new battle plan. Perspective on combating drug-resistant malaria. Embo Reports. 2: 77-9. PMID 11258713 DOI: 10.1093/Embo-Reports/Kve032  0.388
2000 Duraisingh MT, Roper C, Walliker D, Warhurst DC. Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum. Molecular Microbiology. 36: 955-61. PMID 10844681 DOI: 10.1046/J.1365-2958.2000.01914.X  0.345
2000 Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC. The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Molecular and Biochemical Parasitology. 108: 13-23. PMID 10802315 DOI: 10.1016/S0166-6851(00)00201-2  0.309
2000 Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC. Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study. Parasitology. 435-40. PMID 10599075 DOI: 10.1017/S0031182099004953  0.326
2000 Price RN, Cassar C, Brockman A, Duraisingh M, van Vugt M, White NJ, Nosten F, Krishna S. The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. Antimicrobial Agents and Chemotherapy. 43: 2943-9. PMID 10582887 DOI: 10.1128/Aac.43.12.2943  0.36
1999 Jelinek T, Kilian AH, Curtis J, Duraisingh MT, Kabagambe G, von Sonnenburg F, Warhurst DC. Plasmodium falciparum: selection of serine 108 of dihydrofolate reductase during treatment of uncomplicated malaria with co-trimoxazole in Ugandan children. The American Journal of Tropical Medicine and Hygiene. 61: 125-30. PMID 10432069 DOI: 10.4269/Ajtmh.1999.61.125  0.337
1998 Jelinek T, Rønn AM, Lemnge MM, Curtis J, Mhina J, Duraisingh MT, Bygbjerg IC, Warhurst DC. Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania. Tropical Medicine & International Health : Tm & Ih. 3: 605-9. PMID 9735930 DOI: 10.1046/J.1365-3156.1998.00280.X  0.367
1998 Duraisingh MT, Curtis J, Warhurst DC. Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Experimental Parasitology. 89: 1-8. PMID 9603482 DOI: 10.1006/Expr.1998.4274  0.362
1998 Curtis J, Duraisingh MT, Warhurst DC. In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. The Journal of Infectious Diseases. 177: 1429-33. PMID 9593041 DOI: 10.1086/517831  0.339
1997 Jelinek T, Rønn AM, Curtis J, Duraisingh MT, Lemnge MM, Mhina J, Bygbjerg IC, Warhurst DC. High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/pyrimethamine resistance. Tropical Medicine & International Health : Tm & Ih. 2: 1075-9. PMID 9391510 DOI: 10.1046/J.1365-3156.1997.D01-189.X  0.387
1997 von Seidlein L, Duraisingh MT, Drakeley CJ, Bailey R, Greenwood BM, Pinder M. Polymorphism of the Pfmdr1 gene and chloroquine resistance in Plasmodium falciparum in The Gambia. Transactions of the Royal Society of Tropical Medicine and Hygiene. 91: 450-3. PMID 9373652 DOI: 10.1016/S0035-9203(97)90281-9  0.308
1997 Curtis J, Duraisingh MT, Trigg JK, Mbwana H, Warhurst DC, Curtis CF. Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania. Transactions of the Royal Society of Tropical Medicine and Hygiene. 90: 678-80. PMID 9015515 DOI: 10.1016/S0035-9203(96)90432-0  0.379
1997 Adagu IS, Ogala WN, Carucci DJ, Duraisingh MT, Warhurst DC. Field chloroquine-resistance determinants Annals of Tropical Medicine & Parasitology. 91: S107-S111. DOI: 10.1080/00034983.1997.11813248  0.309
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