Nathaniel Sharp - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 

22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Bao K, Strayer BR, Braker NP, Chan AA, Sharp NP. Mutations in yeast are deleterious on average regardless of the degree of adaptation to the testing environment. Proceedings. Biological Sciences. 291: 20240064. PMID 38889780 DOI: 10.1098/rspb.2024.0064  0.511
2023 Sharp NP, Smith DR, Driscoll G, Sun K, Vickerman CM, Martin SCT. Contribution of Spontaneous Mutations to Quantitative and Molecular Variation at the Highly Repetitive rDNA Locus in Yeast. Genome Biology and Evolution. 15. PMID 37847861 DOI: 10.1093/gbe/evad179  0.519
2022 Bao K, Melde RH, Sharp NP. Are mutations usually deleterious? A perspective on the fitness effects of mutation accumulation. Evolutionary Ecology. 36: 753-766. PMID 36245676 DOI: 10.1007/s10682-022-10187-4  0.725
2022 Melde RH, Bao K, Sharp NP. Recent insights into the evolution of mutation rates in yeast. Current Opinion in Genetics & Development. 76: 101953. PMID 35834945 DOI: 10.1016/j.gde.2022.101953  0.727
2022 Sharp N. Mutations matter even if proteins stay the same. Nature. PMID 35676345 DOI: 10.1038/d41586-022-01091-6  0.371
2022 Sandell L, Sharp NP. Fitness Effects of Mutations: An Assessment of PROVEAN Predictions Using Mutation Accumulation Data. Genome Biology and Evolution. 14. PMID 35038732 DOI: 10.1093/gbe/evac004  0.429
2021 Gerstein AC, Sharp NP. The population genetics of ploidy change in unicellular fungi. Fems Microbiology Reviews. PMID 33503232 DOI: 10.1093/femsre/fuab006  0.752
2019 Sharp NP, Whitlock MC. No evidence of positive assortative mating for genetic quality in fruit flies. Proceedings. Biological Sciences. 286: 20191474. PMID 31575372 DOI: 10.1098/Rspb.2019.1474  0.637
2018 Sharp NP, Agrawal AF. An experimental test of the mutation-selection balance model for the maintenance of genetic variance in fitness components. Proceedings. Biological Sciences. 285. PMID 30404880 DOI: 10.1098/rspb.2018.1864  0.709
2018 Sharp NP, Sandell L, James CG, Otto SP. The genome-wide rate and spectrum of spontaneous mutations differ between haploid and diploid yeast. Proceedings of the National Academy of Sciences of the United States of America. PMID 29760081 DOI: 10.1073/pnas.1801040115  0.756
2018 Sharp NP, Otto SP. Evolution: Zeroing In on the Rate of Genome Doubling. Current Biology : Cb. 28: R320-R322. PMID 29614292 DOI: 10.1016/j.cub.2018.02.026  0.637
2017 Gilbert KJ, Sharp NP, Angert AL, Conte GL, Draghi JA, Guillaume F, Hargreaves AL, Matthey-Doret R, Whitlock MC. Local Adaptation Interacts with Expansion Load during Range Expansion: Maladaptation Reduces Expansion Load. The American Naturalist. 189: 368-380. PMID 28350500 DOI: 10.1086/690673  0.64
2016 Sharp NP, Otto SP. Evolution of sex: Using experimental genomics to select among competing theories. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. PMID 27315146 DOI: 10.1002/bies.201600074  0.712
2016 Sharp NP, Agrawal AF. Low Genetic Quality Alters Key Dimensions of the Mutational Spectrum. Plos Biology. 14: e1002419. PMID 27015430 DOI: 10.1371/journal.pbio.1002419  0.743
2015 Sharp NP, Agrawal AF. The decline in fitness with inbreeding: evidence for negative dominance-by-dominance epistasis in Drosophila melanogaster. Journal of Evolutionary Biology. PMID 26709722 DOI: 10.1111/jeb.12815  0.623
2014 Wang AD, Sharp NP, Agrawal AF. Sensitivity of the distribution of mutational fitness effects to environment, genetic background, and adaptedness: a case study with Drosophila. Evolution; International Journal of Organic Evolution. 68: 840-53. PMID 24206451 DOI: 10.1111/evo.12309  0.694
2013 Sharp NP, Agrawal AF. Male-biased fitness effects of spontaneous mutations in Drosophila melanogaster. Evolution; International Journal of Organic Evolution. 67: 1189-95. PMID 23550766 DOI: 10.1111/j.1558-5646.2012.01834.x  0.657
2012 Clark SC, Sharp NP, Rowe L, Agrawal AF. Relative effectiveness of mating success and sperm competition at eliminating deleterious mutations in Drosophila melanogaster. Plos One. 7: e37351. PMID 22662148 DOI: 10.1371/Journal.Pone.0037351  0.707
2012 Sharp NP, Agrawal AF. Evidence for elevated mutation rates in low-quality genotypes. Proceedings of the National Academy of Sciences of the United States of America. 109: 6142-6. PMID 22451943 DOI: 10.1073/pnas.1118918109  0.736
2009 Wang AD, Sharp NP, Spencer CC, Tedman-Aucoin K, Agrawal AF. Selection, epistasis, and parent-of-origin effects on deleterious mutations across environments in Drosophila melanogaster. The American Naturalist. 174: 863-74. PMID 19852616 DOI: 10.1086/645088  0.709
2009 Sharp NP, Agrawal AF. Sexual selection and the random union of gametes: testing for a correlation in fitness between mates in Drosophila melanogaster. The American Naturalist. 174: 613-22. PMID 19757995 DOI: 10.1086/605960  0.62
2008 Sharp NP, Agrawal AF. Mating density and the strength of sexual selection against deleterious alleles in Drosophila melanogaster. Evolution; International Journal of Organic Evolution. 62: 857-67. PMID 18221380 DOI: 10.1111/j.1558-5646.2008.00333.x  0.642
Show low-probability matches.