Fyodor Urnov - Publications

Affiliations: 
Molecular and Cell Biology University of California, Berkeley, Berkeley, CA, United States 
Area:
Engineered zinc finger DNA binding proteins

11/131 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lazar JE, Stehling-Sun S, Nandakumar V, Wang H, Chee DR, Howard NP, Acosta R, Dunn D, Diegel M, Neri F, Castillo A, Ibarrientos S, Lee K, Lescano N, Van Biber B, ... ... Urnov FD, et al. Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling. Cell Reports. 31: 107676. PMID 32460018 DOI: 10.1016/J.Celrep.2020.107676  0.32
2016 Urnov F. Genome editing: The domestication of Cas9 Nature. 529: 468-469. PMID 26819037 DOI: 10.1038/529468A  0.3
2011 Miller JC, Tan S, Qiao G, Barlow KA, Wang J, Xia DF, Meng X, Paschon DE, Leung E, Hinkley SJ, Dulay GP, Hua KL, Ankoudinova I, Cost GJ, Urnov FD, et al. A TALE nuclease architecture for efficient genome editing. Nature Biotechnology. 29: 143-8. PMID 21179091 DOI: 10.1038/Nbt.1755  0.326
2009 Brunet E, Simsek D, Tomishima M, DeKelver R, Choi VM, Gregory P, Urnov F, Weinstock DM, Jasin M. Chromosomal translocations induced at specified loci in human stem cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 10620-5. PMID 19549848 DOI: 10.1073/Pnas.0902076106  0.342
2007 Lombardo A, Genovese P, Beausejour CM, Colleoni S, Lee YL, Kim KA, Ando D, Urnov FD, Galli C, Gregory PD, Holmes MC, Naldini L. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nature Biotechnology. 25: 1298-306. PMID 17965707 DOI: 10.1016/J.Bcmd.2007.10.064  0.384
2007 Moehle EA, Moehle EA, Rock JM, Rock JM, Lee YL, Lee YL, Jouvenot Y, Jouvenot Y, DeKelver RC, Dekelver RC, Gregory PD, Gregory PD, Urnov FD, Urnov FD, Holmes MC, et al. Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases. Proceedings of the National Academy of Sciences of the United States of America. 104: 3055-60. PMID 17360608 DOI: 10.1073/Pnas.0611478104  0.32
2006 Urnov FD, Lombardo A, Rock J, Moehle E, Miller JC, Lee Y, Gregory PD, Naldini L, Holmes MC. 1003. Targeted Site-Specific Integration in Human Cells Using Designed Zinc Finger Nucleases Molecular Therapy. 13: S386-S387. DOI: 10.1016/J.Ymthe.2006.08.1097  0.3
2004 Miller JC, Holmes M, Urnov F, Jamieson AC, Pabo CO. 714. Structure-Based Engineering of the FokI DNA Cleavage Domain in the Context of a Chimeric Endonuclease: Towards Maximally Efficient |[ldquo]|Gene Editing|[rdquo]| Therapy Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.620  0.304
2004 Snowden AW, Zhang L, Urnov F, Dent C, McNamara AR, Jouvenot Y, Zhang SH, Rebar EJ, Jamieson AC, Case CC, Gregory PD. 649. Repression of Vascular Endothelial Growth Factor-A Over-Expression in Glioblastoma Cells Using Engineered Zinc-Finger Transcription Factors Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.593  0.307
2002 Reik A, Gregory PD, Urnov FD. Biotechnologies and therapeutics: chromatin as a target. Current Opinion in Genetics & Development. 12: 233-42. PMID 11893498 DOI: 10.1016/S0959-437X(02)00291-5  0.304
1999 Collingwood TN, Urnov FD, Wolffe AP. Nuclear receptors: Coactivators, corepressors and chromatin remodeling in the control of transcription Journal of Molecular Endocrinology. 23: 255-275. PMID 10601972 DOI: 10.1677/Jme.0.0230255  0.309
Low-probability matches (unlikely to be authored by this person)
2005 Urnov FD, Miller JC, Lee YL, Beausejour CM, Rock JM, Augustus S, Jamieson AC, Porteus MH, Gregory PD, Holmes MC. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature. 435: 646-51. PMID 15806097 DOI: 10.1038/nature03556  0.3
2002 Urnov F, Crane-Robinson C. Chromatin. The living genome. European Journal of Biochemistry / Febs. 269: 2267. PMID 11985606 DOI: 10.1046/J.1432-1033.2002.02884.X  0.291
2009 Hockemeyer D, Soldner F, Beard C, Gao Q, Mitalipova M, DeKelver RC, Katibah GE, Amora R, Boydston EA, Zeitler B, Meng X, Miller JC, Zhang L, Rebar EJ, Gregory PD, ... Urnov FD, et al. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nature Biotechnology. 27: 851-7. PMID 19680244 DOI: 10.1038/Nbt.1562  0.283
2002 Urnov FD, Rebar EJ. Designed transcription factors as tools for therapeutics and functional genomics. Biochemical Pharmacology. 64: 919-23. PMID 12213587 DOI: 10.1016/S0006-2952(02)01150-4  0.28
2008 Santiago Y, Chan E, Liu PQ, Orlando S, Zhang L, Urnov FD, Holmes MC, Guschin D, Waite A, Miller JC, Rebar EJ, Gregory PD, Klug A, Collingwood TN. Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases. Proceedings of the National Academy of Sciences of the United States of America. 105: 5809-14. PMID 18359850 DOI: 10.1073/pnas.0800940105  0.28
2000 Wolffe AP, Collingwood TN, Li Q, Yee J, Urnov F, Shi YB. Thyroid hormone receptor, v-erbA, and chromatin Vitamins and Hormones. 58: 449-492. PMID 10668407 DOI: 10.1016/S0083-6729(00)58033-9  0.278
2005 Lombardo A, Beausejour C, Urnov FD, Miller JC, Holmes MC, Gregory PD, Naldini L. 346. Gene Correction of X-Linked SCID Using Engineered Zinc Finger Nucleases and Integration Defective Lentiviral Delivery Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.349  0.275
2010 DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, ... ... Urnov FD, et al. Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Research. 20: 1133-42. PMID 20508142 DOI: 10.1101/Gr.106773.110  0.274
2015 Reik A, Chang K, Vierstra J, Psatha N, Stehling-Sun S, Zhou Y, O'Neil CM, Mich A, Miller JC, Lee G, Tan S, Jiang H, Stamatoyannopoulos G, Papayannopoulou T, Rebar EJ, ... ... Urnov FD, et al. 53. From GWAS To the Clinic: Genome-Editing the Human BCL11A Erythroid Enhancer for Fetal Globin Elevation in the Hemoglobinopathies Molecular Therapy. 23: S23-S24. DOI: 10.1016/S1525-0016(16)33658-9  0.273
2018 Lo Sardo V, Chubukov P, Ferguson W, Kumar A, Teng EL, Duran M, Zhang L, Cost G, Engler AJ, Urnov F, Topol EJ, Torkamani A, Baldwin KK. Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing. Cell. PMID 30528432 DOI: 10.1016/J.Cell.2018.11.014  0.272
2010 Urnov FD, Rebar EJ, Holmes MC, Zhang HS, Gregory PD. Genome editing with engineered zinc finger nucleases. Nature Reviews. Genetics. 11: 636-46. PMID 20717154 DOI: 10.1038/nrg2842  0.271
2011 Hockemeyer D, Wang H, Kiani S, Lai CS, Gao Q, Cassady JP, Cost GJ, Zhang L, Santiago Y, Miller JC, Zeitler B, Cherone JM, Meng X, Hinkley SJ, Rebar EJ, ... ... Urnov FD, et al. Genetic engineering of human pluripotent cells using TALE nucleases. Nature Biotechnology. 29: 731-4. PMID 21738127 DOI: 10.1038/Nbt.1927  0.269
2018 Urnov F. An ode to gene edits that prevent deafness Nature. 553: 162-163. PMID 29323325 DOI: 10.1038/D41586-017-08645-Z  0.269
2006 Holmes Ml, Liu L, Perez E, Li L, Shivakumar R, Allen C, Liu O, Miller JC, Urnov FD, Kim K, Rebar EJ, Ando D, Gregory PD, Riley J, Peshwa M, et al. 555. Large-Scale, Flow-Based Electroporation To Deliver Engineered Zinc Finger Protein Nucleases That Mediate High-Efficiency Disruption of the Human CCR5 Gene Molecular Therapy. 13: S214. DOI: 10.1016/J.Ymthe.2006.08.627  0.263
2009 Gargiulo G, Levy S, Bucci G, Romanenghi M, Fornasari L, Beeson KY, Goldberg SM, Cesaroni M, Ballarini M, Santoro F, Bezman N, Frigè G, Gregory PD, Holmes MC, Strausberg RL, ... ... Urnov FD, et al. NA-Seq: a discovery tool for the analysis of chromatin structure and dynamics during differentiation. Developmental Cell. 16: 466-81. PMID 19289091 DOI: 10.1016/j.devcel.2009.02.002  0.263
2003 Urnov FD. Chromatin as a tool for the study of genome function in cancer. Annals of the New York Academy of Sciences. 983: 5-21. PMID 12724208  0.26
2002 Urnov FD, Rebar EJ, Reik A, Pandolfi PP. Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo. Fourth in review series on chromatin dynamics. Embo Reports. 3: 610-5. PMID 12101091 DOI: 10.1093/Embo-Reports/Kvf140  0.259
2001 Urnov FD, Wolffe AP. A necessary good: Nuclear hormone receptors and their chromatin templates Molecular Endocrinology. 15: 1-16. PMID 11145735 DOI: 10.1210/Mend.15.1.0589  0.257
2011 Young JJ, Cherone JM, Doyon Y, Ankoudinova I, Faraji FM, Lee AH, Ngo C, Guschin DY, Paschon DE, Miller JC, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Harland RM, et al. Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases. Proceedings of the National Academy of Sciences of the United States of America. 108: 7052-7. PMID 21471457 DOI: 10.1073/pnas.1102030108  0.256
2009 Cai CQ, Doyon Y, Ainley WM, Miller JC, Dekelver RC, Moehle EA, Rock JM, Lee YL, Garrison R, Schulenberg L, Blue R, Worden A, Baker L, Faraji F, Zhang L, ... ... Urnov FD, et al. Targeted transgene integration in plant cells using designed zinc finger nucleases. Plant Molecular Biology. 69: 699-709. PMID 19112554 DOI: 10.1007/S11103-008-9449-7  0.253
2001 Urnov FD, Wolffe AP. Above and within the genome: Epigenetics past and present Journal of Mammary Gland Biology and Neoplasia. 6: 153-167. PMID 11501576 DOI: 10.1023/A:1011304606604  0.249
2013 Cristea S, Freyvert Y, Santiago Y, Holmes MC, Urnov FD, Gregory PD, Cost GJ. In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration. Biotechnology and Bioengineering. 110: 871-80. PMID 23042119 DOI: 10.1002/Bit.24733  0.247
2011 Doyon Y, Vo TD, Mendel MC, Greenberg SG, Wang J, Xia DF, Miller JC, Urnov FD, Gregory PD, Holmes MC. Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures. Nature Methods. 8: 74-9. PMID 21131970 DOI: 10.1038/nmeth.1539  0.245
1999 Li Q, Imhof A, Collingwood TN, Urnov FD, Wolffe AP. P300 stimulates transcription instigated by ligand-bound thyroid hormone receptor at a step subsequent to chromatin disruption Embo Journal. 18: 5634-5652. PMID 10523307 DOI: 10.1093/emboj/18.20.5634  0.245
2002 Urnov FD. A feel for the template: zinc finger protein transcription factors and chromatin. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 80: 321-33. PMID 12123285 DOI: 10.1139/o02-084  0.242
2006 Reik A, Holmes MC, Urnov FD, Zhou Y, Mendel M, Liu P, Moehle E, Rebar EJ, Miller JC, Ando D, Gregory PD, Jensen M. “Designer” Cells for Cellular Immunotherapy: Zinc Finger Nuclease (ZFN) Stimulated Targeted Recombination for the Simultaneous Disruption of the Endogenous Glucocorticoid Receptor and Site-Specific Addition of the IL13-Zetakine. Blood. 108: 3705-3705. DOI: 10.1182/Blood.V108.11.3705.3705  0.24
2004 Urnov FD. Chromatin targets: Reading and writing the cancer cell epigenome Drug Discovery Today: Disease Models. 1: 43-48. DOI: 10.1016/j.ddmod.2004.08.002  0.24
2011 Wood AJ, Lo TW, Zeitler B, Pickle CS, Ralston EJ, Lee AH, Amora R, Miller JC, Leung E, Meng X, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Meyer BJ. Targeted genome editing across species using ZFNs and TALENs. Science (New York, N.Y.). 333: 307. PMID 21700836 DOI: 10.1126/science.1207773  0.238
2012 Straimer J, Lee MC, Lee AH, Zeitler B, Williams AE, Pearl JR, Zhang L, Rebar EJ, Gregory PD, Llinás M, Urnov FD, Fidock DA. Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases. Nature Methods. 9: 993-8. PMID 22922501 DOI: 10.1038/Nmeth.2143  0.238
2008 Doyon Y, McCammon JM, Miller JC, Faraji F, Ngo C, Katibah GE, Amora R, Hocking TD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Amacher SL. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nature Biotechnology. 26: 702-8. PMID 18500334 DOI: 10.1038/Nbt1409  0.237
2013 Lee GK, Truong L, Wood T, Henley J, Ya-Li L, Kim K, Zhou Y, Wang J, Reik A, Urnov FD, Cannon P, Holmes MC, Ando D, Giedlin MA. Autologous Hematopoietic Stem/Progenitor Cell (HSPC) Therapy For Monogenic Blood Disorders: Scalable, cGMP-Compliant Process For Generating Highly Efficient Genome Edited HSPC Blood. 122: 4213-4213. DOI: 10.1182/Blood.V122.21.4213.4213  0.233
2012 Wang Y, Zhang WY, Hu S, Lan F, Lee AS, Huber B, Lisowski L, Liang P, Huang M, de Almeida PE, Won JH, Sun N, Robbins RC, Kay MA, Urnov FD, et al. Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging. Circulation Research. 111: 1494-503. PMID 22967807 DOI: 10.1161/Circresaha.112.274969  0.233
2001 Urnov FD, Wolffe AP. Chromatin remodeling and transcriptional activation: The cast (in order of appearance) Oncogene. 20: 2991-3006. PMID 11420714 DOI: 10.1038/Sj.Onc.1204323  0.232
2018 Urnov FD. Ctrl-Alt-inDel: genome editing to reprogram a cell in the clinic. Current Opinion in Genetics & Development. 52: 48-56. PMID 29879620 DOI: 10.1016/j.gde.2018.05.005  0.232
2015 See De Ravin S, Reik A, Liu P, Li L, Peshwa MV, Theobald N, Choi U, Lee J, Koontz S, Lee G, Gregory PD, Urnov FD, Malech HL. 54. Genome Editing of Primary Human CD34+ Hematopoietic Stem Cells Enables a Safe Harbor Targeted Gene Addition Therapeutic Strategy for Chronic Granulomatous Disease Molecular Therapy. 23: S24. DOI: 10.1016/S1525-0016(16)33659-0  0.232
2016 De Ravin SS, Reik A, Liu PQ, Li L, Wu X, Su L, Raley C, Theobald N, Choi U, Song AH, Chan A, Pearl JR, Paschon DE, Lee J, Newcombe H, ... ... Urnov FD, et al. Targeted gene addition in human CD34(+) hematopoietic cells for correction of X-linked chronic granulomatous disease. Nature Biotechnology. PMID 26950749 DOI: 10.1038/nbt.3513  0.229
2003 Urnov FD. Chromatin remodeling as a guide to transcriptional regulatory networks in mammals. Journal of Cellular Biochemistry. 88: 684-94. PMID 12577302 DOI: 10.1002/jcb.10397  0.229
2003 Snowden AW, Zhang L, Urnov F, Dent C, Jouvenot Y, Zhong X, Rebar EJ, Jamieson AC, Zhang HS, Tan S, Case CC, Pabo CO, Wolffe AP, Gregory PD. Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors. Cancer Research. 63: 8968-76. PMID 14695215  0.228
2001 Urnov FD, Wolffe AP. An Array of Positioned Nucleosomes Potentiates Thyroid Hormone Receptor Action in Vivo Journal of Biological Chemistry. 276: 19753-19761. PMID 11274156 DOI: 10.1074/jbc.M100924200  0.228
2010 Orlando SJ, Santiago Y, DeKelver RC, Freyvert Y, Boydston EA, Moehle EA, Choi VM, Gopalan SM, Lou JF, Li J, Miller JC, Holmes MC, Gregory PD, Urnov FD, Cost GJ. Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology. Nucleic Acids Research. 38: e152. PMID 20530528 DOI: 10.1093/Nar/Gkq512  0.228
2002 Urnov FD. Methylation and the genome: the power of a small amendment. The Journal of Nutrition. 132: 2450S-2456S. PMID 12163710  0.227
2018 Woo J, Stehling-Sun S, Deeg HJ, Papayannopoulou T, Urnov FD, Stamatoyannopoulos JA. Regulatory Reprogramming of Erythropoiesis By DNMT3A Mutation Blood. 132: 4343-4343. DOI: 10.1182/Blood-2018-99-120110  0.226
2012 Gupta M, DeKelver RC, Palta A, Clifford C, Gopalan S, Miller JC, Novak S, Desloover D, Gachotte D, Connell J, Flook J, Patterson T, Robbins K, Rebar EJ, Gregory PD, ... Urnov FD, et al. Transcriptional activation of Brassica napus β-ketoacyl-ACP synthase II with an engineered zinc finger protein transcription factor. Plant Biotechnology Journal. 10: 783-91. PMID 22520333 DOI: 10.1111/j.1467-7652.2012.00695.x  0.223
2013 Li J, Blue R, Zeitler B, Strange TL, Pearl JR, Huizinga DH, Evans S, Gregory PD, Urnov FD, Petolino JF. Activation domains for controlling plant gene expression using designed transcription factors. Plant Biotechnology Journal. 11: 671-80. PMID 23521778 DOI: 10.1111/pbi.12057  0.222
2015 Lanphier E, Urnov F, Haecker SE, Werner M, Smolenski J. Don't edit the human germ line. Nature. 519: 410-1. PMID 25810189 DOI: 10.1038/519410A  0.22
2014 Urnov FD. Taking it to the Clinic: Genome Editing for Blood Disorders Blood. 124: SCI-12-SCI-12. DOI: 10.1182/BLOOD.V124.21.SCI-12.SCI-12  0.22
2013 Ainley WM, Sastry-Dent L, Welter ME, Murray MG, Zeitler B, Amora R, Corbin DR, Miles RR, Arnold NL, Strange TL, Simpson MA, Cao Z, Carroll C, Pawelczak KS, Blue R, ... ... Urnov FD, et al. Trait stacking via targeted genome editing. Plant Biotechnology Journal. 11: 1126-34. PMID 23953646 DOI: 10.1111/pbi.12107  0.219
2013 Jiang J, Jing Y, Cost GJ, Chiang JC, Kolpa HJ, Cotton AM, Carone DM, Carone BR, Shivak DA, Guschin DY, Pearl JR, Rebar EJ, Byron M, Gregory PD, Brown CJ, ... Urnov FD, et al. Translating dosage compensation to trisomy 21. Nature. 500: 296-300. PMID 23863942 DOI: 10.1038/Nature12394  0.218
2015 Vierstra J, Reik A, Chang KH, Stehling-Sun S, Zhou Y, Hinkley SJ, Paschon DE, Zhang L, Psatha N, Bendana YR, O'Neil CM, Song AH, Mich AK, Liu PQ, Lee G, ... ... Urnov FD, et al. Functional footprinting of regulatory DNA. Nature Methods. PMID 26322838 DOI: 10.1038/Nmeth.3554  0.214
2006 Lombardo A, Beausejour C, Urnov FD, Miller JC, Aiuti A, Gregory PD, Holmes MC, Naldini L. 738. Towards Gene Correction of X-Linked SCID Using Engineered Zinc Finger Nucleases and Integrase Defective Lentiviral Delivery Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.819  0.213
2001 Collingwood TN, Urnov FD, Chatterjee VKK, Wolffe AP. Chromatin Remodeling by the Thyroid Hormone Receptor in Regulation of the Thyroid-stimulating Hormone α-Subunit Promoter Journal of Biological Chemistry. 276: 34227-34234. PMID 11454868 DOI: 10.1074/jbc.M105172200  0.211
2001 Archer T, Baylin S, Hansen J, Hayes J, Pelicci PG, Robertson K, Stunnenberg H, Urnov F, Wade P. Dr Alan P Wolffe 1959–2001 Oncogene. 20: 4439-4439. DOI: 10.1038/Sj.Onc.1204716  0.21
2015 Urnov FD, Reik A, Vierstra J, Chang K, Zhou Y, Mich A, Adrian J, Fox L, Psatha N, Tan S, Yannaki E, Craig S, Rebar EJ, Stamatoyannopoulos J, Papayannopoulou T, et al. Clinical-Scale Genome Editing of the Human BCL11A Erythroid Enhancer for Treatment of the Hemoglobinopathies Blood. 126: 204-204. DOI: 10.1182/Blood.V126.23.204.204  0.209
2002 Urnov F. In memoriam – Alan P. Wolffe (21.6.1959–26.5.2001) Chromosoma. 111: 289-290. DOI: 10.1007/S00412-002-0219-Z  0.209
2009 Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X, Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, ... ... Urnov FD, et al. Knockout rats via embryo microinjection of zinc-finger nucleases. Science (New York, N.Y.). 325: 433. PMID 19628861 DOI: 10.1126/Science.1172447  0.207
2011 Doyon JB, Zeitler B, Cheng J, Cheng AT, Cherone JM, Santiago Y, Lee AH, Vo TD, Doyon Y, Miller JC, Paschon DE, Zhang L, Rebar EJ, Gregory PD, Urnov FD, et al. Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells. Nature Cell Biology. 13: 331-7. PMID 21297641 DOI: 10.1038/Ncb2175  0.206
2006 Davis BR, Prokopishyn NL, Rosenberg J, DiCola M, Brosius J, Blaese RM, Metz RA, Zhang L, Xia D, Miller JC, Kim K, Urnov FD, Gregory PD, Holmes MC. 1040. Towards Gene Correction Therapy for Wiskott-Aldrich Syndrome Using Designed Zinc Finger Endonucleases Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.1136  0.205
2002 Urnov FD, Liang C, Blitzblau HG, Smith HS, Gerbi SA. A DNase I hypersensitive site flanks an origin of DNA replication and amplification in Sciara. Chromosoma. 111: 291-303. PMID 12474058 DOI: 10.1007/S00412-002-0194-4  0.203
2018 Pearl J, Urnov FD, Stamatoyannopoulos JA. Potent and Timed Epigenetic Repression of PD-1 in Human T Cells Blood. 132: 3493-3493. DOI: 10.1182/Blood-2018-99-119011  0.203
2000 Urnov FD, Yee J, Sachs L, Collingwood TN, Bauer A, Beug H, Shi YB, Wolffe AP. Targeting of N-CoR and histone deacetylase 3 by the oncoprotein v-ErbA yields a chromatin infrastructure-dependent transcriptional repression pathway Embo Journal. 19: 4074-4090. PMID 10921888 DOI: 10.1093/Emboj/19.15.4074  0.201
2000 Wolffe AP, Urnov FD, Guschin D. Co-repressor complexes and remodelling chromatin for repression Biochemical Society Transactions. 28: 379-386. PMID 10961924  0.2
2000 Wolffe AP, Urnov FD, Guschin D. Co-repressor complexes and remodelling chromatin for repression. Biochemical Society Transactions. 28: 379-386. DOI: 10.1042/Bst0280379  0.2
2014 Urnov FD. Human genome editing as a tool to establish causality. Proceedings of the National Academy of Sciences of the United States of America. 111: 1233-4. PMID 24429346 DOI: 10.1073/pnas.1322645111  0.197
2000 Urnov FD, Wolffe AP, Guschin D. Molecular mechanisms of corepressor function Current Topics in Microbiology and Immunology. 254: 1-33. PMID 11190568 DOI: 10.1007/978-3-662-10595-5_1  0.195
2014 Sexton AN, Regalado SG, Lai CS, Cost GJ, O'Neil CM, Urnov FD, Gregory PD, Jaenisch R, Collins K, Hockemeyer D. Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation. Genes & Development. 28: 1885-99. PMID 25128433 DOI: 10.1101/Gad.246819.114  0.194
2015 Chang K, Sullivan T, Liu M, Yang X, Sun C, Vieira B, Zhang M, Hong VP, Chen K, Smith S, Tan S, Reik A, Urnov FD, Rebar EJ, Danos O, et al. Clonal Analysis of Human Bone Marrow CD34+ Cells Edited By BCL11A-Targeting Zinc Finger Nucleases Reveals Clinically Relevant Levels of Fetal Globin Expression in Edited Erythroid Progeny Blood. 126: 3234-3234. DOI: 10.1182/BLOOD.V126.23.3234.3234  0.194
1996 Gerbi SA, Urnov FD. 35 Differential DNA Replication in Insects Cold Spring Harbor Monograph Archive. 31: 947-969. DOI: 10.1101/087969459.31.947  0.193
2011 Soldner F, Laganière J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Myers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu BJ, Meng X, ... Urnov FD, et al. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell. 146: 318-31. PMID 21757228 DOI: 10.1016/J.Cell.2011.06.019  0.192
2010 Goldberg AD, Banaszynski LA, Noh KM, Lewis PW, Elsaesser SJ, Stadler S, Dewell S, Law M, Guo X, Li X, Wen D, Chapgier A, DeKelver RC, Miller JC, Lee YL, ... ... Urnov FD, et al. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell. 140: 678-91. PMID 20211137 DOI: 10.1016/J.Cell.2010.01.003  0.191
2011 Cristea S, Gregory PD, Urnov FD, Cost GJ. Dissection of splicing regulation at an endogenous locus by zinc-finger nuclease-mediated gene editing. Plos One. 6: e16961. PMID 21347446 DOI: 10.1371/Journal.Pone.0016961  0.189
2017 Chang KH, Smith SE, Sullivan T, Chen K, Zhou Q, West JA, Liu M, Liu Y, Vieira BF, Sun C, Hong VP, Zhang M, Yang X, Reik A, Urnov FD, et al. Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34(+) Hematopoietic Stem and Progenitor Cells. Molecular Therapy. Methods & Clinical Development. 4: 137-148. PMID 28344999 DOI: 10.1016/j.omtm.2016.12.009  0.18
2018 Urnov FD. Genome Editing B.C. (Before CRISPR): Lasting Lessons from the "Old Testament". The Crispr Journal. 1: 34-46. PMID 31021186 DOI: 10.1089/crispr.2018.29007.fyu  0.18
2015 Miller JC, Zhang L, Xia DF, Campo JJ, Ankoudinova IV, Guschin DY, Babiarz JE, Meng X, Hinkley SJ, Lam SC, Paschon DE, Vincent AI, Dulay GP, Barlow KA, Shivak DA, ... ... Urnov FD, et al. Improved specificity of TALE-based genome editing using an expanded RVD repertoire. Nature Methods. 12: 465-71. PMID 25799440 DOI: 10.1038/nmeth.3330  0.179
2019 Zeitler B, Froelich S, Marlen K, Shivak DA, Yu Q, Li D, Pearl JR, Miller JC, Zhang L, Paschon DE, Hinkley SJ, Ankoudinova I, Lam S, Guschin D, Kopan L, ... ... Urnov FD, et al. Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease. Nature Medicine. PMID 31263285 DOI: 10.1038/S41591-019-0478-3  0.176
2020 Lazar JE, Stehling-Sun S, Nandakumar V, Wang H, Chee DR, Howard NP, Acosta R, Dunn D, Diegel M, Neri F, Castillo A, Ibarrientos S, Lee K, Lescano N, Van Biber B, ... ... Urnov FD, et al. Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling. Cell Reports. 31: 107788. PMID 32579918 DOI: 10.1016/j.celrep.2020.107788  0.175
2018 Psatha N, Reik A, Phelps S, Zhou Y, Dalas D, Yannaki E, Levasseur DN, Urnov FD, Holmes MC, Papayannopoulou T. Disruption of the BCL11A Erythroid Enhancer Reactivates Fetal Hemoglobin in Erythroid Cells of Patients with β-Thalassemia Major. Molecular Therapy. Methods & Clinical Development. 10: 313-326. PMID 30182035 DOI: 10.1016/J.Omtm.2018.08.003  0.175
2021 Urnov FD. The Cas9 Hammer-and Sickle: A Challenge for Genome Editors. The Crispr Journal. 4: 6-13. PMID 33616446 DOI: 10.1089/crispr.2021.29120.fur  0.173
2018 Urnov F. An ode to gene edits that prevent deafness. Nature. 553: 162-163. PMID 32086502 DOI: 10.1038/d41586-017-08645-z  0.169
2013 Foulk MS, Waggener JM, Johnson JM, Yamamoto Y, Liew GM, Urnov FD, Young Y, Lee G, Smith HS, Gerbi SA. Isolation and characterization of the ecdysone receptor and its heterodimeric partner ultraspiracle through development in Sciara coprophila. Chromosoma. 122: 103-19. PMID 23321980 DOI: 10.1007/S00412-012-0395-4  0.166
2009 Shukla VK, Doyon Y, Miller JC, DeKelver RC, Moehle EA, Worden SE, Mitchell JC, Arnold NL, Gopalan S, Meng X, Choi VM, Rock JM, Wu YY, Katibah GE, Zhifang G, ... ... Urnov FD, et al. Precise genome modification in the crop species Zea mays using zinc-finger nucleases. Nature. 459: 437-41. PMID 19404259 DOI: 10.1038/Nature07992  0.166
2014 Wang Y, Liang P, Lan F, Wu H, Lisowski L, Gu M, Hu S, Kay MA, Urnov FD, Shinnawi R, Gold JD, Gepstein L, Wu JC. Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing. Journal of the American College of Cardiology. 64: 451-9. PMID 25082577 DOI: 10.1016/J.Jacc.2014.04.057  0.163
2009 Phillips CM, Meng X, Zhang L, Chretien JH, Urnov FD, Dernburg AF. Identification of chromosome sequence motifs that mediate meiotic pairing and synapsis in C. elegans. Nature Cell Biology. 11: 934-42. PMID 19620970 DOI: 10.1038/ncb1904  0.16
2020 Urnov FD. Prime Time for Genome Editing? The New England Journal of Medicine. 382: 481-484. PMID 31995698 DOI: 10.1056/NEJMcibr1914271  0.159
2015 Tan S, Chang K, Smith S, Chen K, Sullivan T, Zhou Q, Reik A, Urnov FD, Rebar EJ, Danos O, Jiang H. Genome Editing of the Bcl11A Erythroid Specific Enhancer in Bone Marrow Derived Hematopoietic Stem and Progenitor Cells for the Treatment of Sickle Cell Disease Blood. 126: 203-203. DOI: 10.1182/blood.v126.23.203.203  0.154
2012 Trifonova EA, Eremina ER, Urnov FD, Stepanov VA. The Genetic Diversity and Structure of Linkage Disequilibrium of the MTHFR Gene in Populations of Northern Eurasia Acta Naturae. 4: 53-69. DOI: 10.32607/20758251-2012-4-1-53-69  0.15
2021 Wegmann S, DeVos SL, Zeitler B, Marlen K, Bennett RE, Perez-Rando M, MacKenzie D, Yu Q, Commins C, Bannon RN, Corjuc BT, Chase A, Diez L, Nguyen HB, Hinkley S, ... ... Urnov FD, et al. Persistent repression of tau in the brain using engineered zinc finger protein transcription factors. Science Advances. 7. PMID 33741591 DOI: 10.1126/sciadv.abe1611  0.149
2000 Urnov FD, Wolffe AP. Chromatin organisation and human disease Expert Opinion On Therapeutic Targets. 4: 665-685. DOI: 10.1517/14728222.4.5.665  0.148
2021 Abou-El-Enein M, Angelis A, Appelbaum FR, Andrews NC, Bates SE, Bierman AS, Brenner MK, Cavazzana M, Caligiuri MA, Clevers H, Cooke E, Daley GQ, Dzau VJ, Ellis LM, Fineberg HV, ... ... Urnov FD, et al. Evidence generation and reproducibility in cell and gene therapy research: A call to action. Molecular Therapy. Methods & Clinical Development. 22: 11-14. PMID 34377737 DOI: 10.1016/j.omtm.2021.06.012  0.147
2014 Urnov FD. Biological techniques: Edit the genome to understand it. Nature. 513: 40-1. PMID 25141180 DOI: 10.1038/nature13659  0.145
2016 Lillico SG, Proudfoot C, King TJ, Tan W, Zhang L, Mardjuki R, Paschon DE, Rebar EJ, Urnov FD, Mileham AJ, McLaren DG, Whitelaw CB. Mammalian interspecies substitution of immune modulatory alleles by genome editing. Scientific Reports. 6: 21645. PMID 26898342 DOI: 10.1038/srep21645  0.145
2014 Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GJ, Chan A, Rebar EJ, Urnov FD, Gregory PD, Pachter L, et al. Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells. Stem Cell Reports. 2: 838-52. PMID 24936470 DOI: 10.1016/J.Stemcr.2014.05.001  0.141
2018 Urnov FD. A path to efficient gene editing. Nature Medicine. 24: 899-900. PMID 29988144 DOI: 10.1038/s41591-018-0110-y  0.14
2019 Urnov FD. Hijack of CRISPR defences by selfish genes holds clinical promise. Nature. 571: 180-181. PMID 31285598 DOI: 10.1038/d41586-019-01824-0  0.133
2020 Kiem HP, Gaudelli NN, Urnov FD, Frederickson RM, Herzog RW. Call for Papers: Expanding the Scale and Scope of Therapeutic Gene Editing. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 32679031 DOI: 10.1016/j.ymthe.2020.07.007  0.133
2015 Ando D, Walters MC, Chang K, Reik A, Urnov FD, Lee G, Spratt KS, Rebar EJ, Gregory PD, Tang W, Papayannopoulou T, Stamatoyannopoulos G, Nichol G. 239. Preclinical Studies for the First Hematopoietic Stem Cell (HSC) Gene Editing Trial: Phase 1 Study of Beta-Thalassemia With Autologous Transplantation of Zinc Finger Nuclease-Treated HSC To Upregulate Fetal Hemoglobin Molecular Therapy. 23: S93-S94. DOI: 10.1016/S1525-0016(16)33844-8  0.127
2020 Stahl EC, Tsuchida CA, Hamilton JR, Lin-Shiao E, McDevitt SL, Moehle EA, Witkowsky LB, Tsui CK, Pestal K, Gildea HK, McElroy M, Keller A, Sylvain I, Williams C, Hirsh A, ... ... Urnov FD, et al. IGI-LuNER: single-well multiplexed RT-qPCR test for SARS-CoV-2. Medrxiv : the Preprint Server For Health Sciences. PMID 33330883 DOI: 10.1101/2020.12.10.20247338  0.124
2014 Sanders LH, Laganière J, Cooper O, Mak SK, Vu BJ, Huang YA, Paschon DE, Vangipuram M, Sundararajan R, Urnov FD, Langston JW, Gregory PD, Zhang HS, Greenamyre JT, Isacson O, et al. LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction. Neurobiology of Disease. 62: 381-6. PMID 24148854 DOI: 10.1016/J.Nbd.2013.10.013  0.123
2012 Trifonova EA, Spiridonova MG, Gabidulina TV, Urnov FD, Puzyrev VP, Stepanov VA. [Analysis of the MTHFR gene linkage disequilibrium structure and association of polymorphic gene variants with coronary atherosclerosis] Genetika. 48: 1207-1220. PMID 23270270  0.111
2012 Trifonova EA, Spiridonova MG, Gabidulina TV, Urnov FD, Puzyrev VP, Stepanov VA. Analysis of the MTHFR gene linkage disequilibrium structure and association of polymorphic gene variants with coronary atherosclerosis Russian Journal of Genetics. 48: 1035-1047. DOI: 10.1134/S1022795412100122  0.111
2014 Forster R, Chiba K, Schaeffer L, Regalado S, Lai C, Gao Q, Kiani S, Farin H, Clevers H, Cost G, Chan A, Rebar E, Urnov F, Gregory P, Pachter L, et al. Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells Stem Cell Reports. 3: 215. DOI: 10.1016/J.Stemcr.2014.06.014  0.111
2021 Stahl EC, Gopez AR, Tsuchida CA, Fan VB, Moehle EA, Witkowsky LB, Hamilton JR, Lin-Shiao E, McElroy M, McDevitt SL, Ciling A, Tsui CK, Pestal K, Gildea HK, Keller A, ... ... Urnov FD, et al. LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples. Plos One. 16: e0258263. PMID 34758033 DOI: 10.1371/journal.pone.0258263  0.106
1993 Gerbi SA, Liang C, Wu N, DiBartolomeis SM, Bienz-Tadmor B, Smith HS, Urnov FD. DNA amplification in DNA puff II/9A of Sciara coprophila. Cold Spring Harbor Symposia On Quantitative Biology. 58: 487-94. PMID 7956063 DOI: 10.1101/Sqb.1993.058.01.055  0.095
2008 Perez EE, Wang J, Miller JC, Jouvenot Y, Kim KA, Liu O, Wang N, Lee G, Bartsevich VV, Lee YL, Guschin DY, Rupniewski I, Waite AJ, Carpenito C, Carroll RG, ... ... Urnov FD, et al. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nature Biotechnology. 26: 808-16. PMID 18587387 DOI: 10.1038/Nbt1410  0.088
2021 Urnov FD. CRISPR-Cas9 can cause chromothripsis. Nature Genetics. 53: 768-769. PMID 34103715 DOI: 10.1038/s41588-021-00881-4  0.088
2018 Urnov FD, Ronald PC, Carroll D. A call for science-based review of the European court's decision on gene-edited crops. Nature Biotechnology. 36: 800-802. PMID 30188544 DOI: 10.1038/Nbt.4252  0.087
2016 Chiocco M, Choi V, Graham A, Klatte D, Francone O, Thomson D, Zeitler B, Froelich S, Yu Q, Paschon DE, Miller JC, Marlen K, Rebar EJ, Urnov FD, Gregory PD, et al. A7 Drug discovery approach for rare neurological diseases: using novel zinc finger protein technology to develop potential therapy for huntington’s disease Journal of Neurology, Neurosurgery & Psychiatry. 87: A2.4-A3. DOI: 10.1136/jnnp-2016-314597.7  0.067
2021 Urnov FD. Imagine CRISPR cures. Molecular Therapy : the Journal of the American Society of Gene Therapy. 29: 3103-3106. PMID 34710352 DOI: 10.1016/j.ymthe.2021.10.019  0.064
2010 Williams S, Urnov F, Zhang L, Moraes C. 34 Zinc finger nucleases targeted to the m.3243A>G mutation in mitochondrial encephalomyopathy (MELAS) Mitochondrion. 10: 209. DOI: 10.1016/J.Mito.2009.12.032  0.063
2017 Urnov FD. Cas9 in action: no more known unknowns? Nature Methods. 14: 563-564. PMID 28557979 DOI: 10.1038/nmeth.4301  0.058
2015 Straimer J, Gnädig NF, Witkowski B, Amaratunga C, Duru V, Ramadani AP, Dacheux M, Khim N, Zhang L, Lam S, Gregory PD, Urnov FD, Mercereau-Puijalon O, Benoit-Vical F, Fairhurst RM, et al. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates Science. 347: 428-431. PMID 25502314 DOI: 10.1126/Science.1260867  0.05
2020 Urnov F. SARS-Cov2 Clinical Diagnostics: Academic Scientists Take on the COVID-19 Pandemic. Med (New York, N.Y.). 1: 11-13. PMID 32838356 DOI: 10.1016/j.medj.2020.06.002  0.049
2021 Hamilton JR, Stahl EC, Tsuchida CA, Lin-Shiao E, Tsui CK, Pestal K, Gildea HK, Witkowsky LB, Moehle EA, McDevitt SL, McElroy M, Keller A, Sylvain I, Hirsh A, Ciling A, ... ... Urnov FD, et al. Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples. Plos One. 16: e0255690. PMID 34351984 DOI: 10.1371/journal.pone.0255690  0.047
2021 Hamilton JR, Stahl EC, Tsuchida CA, Lin-Shiao E, Tsui CK, Pestal K, Gildea HK, Witkowsky LB, Moehle EA, McDevitt SL, McElroy M, Keller A, Sylvain I, Hirsh A, Ciling A, ... ... Urnov FD, et al. Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples. Medrxiv : the Preprint Server For Health Sciences. PMID 33532798 DOI: 10.1101/2021.01.10.21249151  0.046
2024 Ecker DJ, Aiello CD, Arron JR, Bennett CF, Bernard A, Breakefield XO, Broderick TJ, Callier SL, Canton B, Chen JS, Fishburn CS, Garrett B, Hecht SM, Janowitz T, Kliegman M, ... ... Urnov F, et al. Opportunities and challenges for innovative and equitable healthcare. Nature Reviews. Drug Discovery. PMID 38409339 DOI: 10.1038/d41573-024-00032-4  0.038
2021 Ehrenberg AJ, Moehle EA, Brook CE, Doudna Cate AH, Witkowsky LB, Sachdeva R, Hirsh A, Barry K, Hamilton JR, Lin-Shiao E, McDevitt S, Valentin-Alvarado L, Letourneau KN, Hunter L, Keller A, ... ... Urnov FD, et al. Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus. Plos One. 16: e0251296. PMID 34038425 DOI: 10.1371/journal.pone.0251296  0.032
2023 Urnov F. : CRISPR Trials. The Crispr Journal. 6: 488. PMID 38108520 DOI: 10.1089/crispr.2023.29166.cfp2  0.031
2023 Urnov F. : CRISPR Trials. The Crispr Journal. 6: 404. PMID 37824833 DOI: 10.1089/crispr.2023.29166.cfp  0.031
2021 Packel L, Reingold A, Hunter L, Facente S, Li Y, Harte A, Nicolette G, Urnov FD, Lu M, Petersen M. Piloting an integrated SARS-CoV-2 testing and data system for outbreak containment among college students: A prospective cohort study. Plos One. 16: e0245765. PMID 33497404 DOI: 10.1371/journal.pone.0245765  0.029
2005 Daniels TJ, Winet H, Smith AA, Meiss RA, O'Hara B, Weis JS, Urnov FD, Hart AG, Friedberg F, Delcourt M, Skell P. Why we invoke Darwin [1] (multiple letters) Scientist. 19: 8+10.  0.028
2001 Urnov F. Biochemistry and molecular biology: Editorial Chemtracts. 14: vii-viii.  0.022
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