Marc W. Kirschner - Publications

Affiliations: 
Systems Biology Harvard Medical School, Boston, MA, United States 
Area:
Cell Cycle, Cytoskeleton, Systems Biology
Website:
http://kirschner.med.harvard.edu/

316 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW. Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands. Developmental Biology. 493: 67-79. PMID 36334838 DOI: 10.1016/j.ydbio.2022.10.013  0.732
2021 Li F, Rane RV, Luria V, Xiong Z, Chen J, Li Z, Catullo RA, Griffin PC, Schiffer M, Pearce S, Lee SF, McElroy K, Stocker A, Shirriffs J, Cockerell F, ... ... Kirschner MW, et al. Phylogenomic analyses of the genus Drosophila reveals genomic signals of climate adaptation. Molecular Ecology Resources. PMID 34839580 DOI: 10.1111/1755-0998.13561  0.685
2021 Prensner JR, Enache OM, Luria V, Krug K, Clauser KR, Dempster JM, Karger A, Wang L, Stumbraite K, Wang VM, Botta G, Lyons NJ, Goodale A, Kalani Z, Fritchman B, ... ... Kirschner MW, et al. Noncanonical open reading frames encode functional proteins essential for cancer cell survival. Nature Biotechnology. PMID 33510483 DOI: 10.1038/s41587-020-00806-2  0.722
2020 Liu X, Simon JM, Xie H, Hu L, Wang J, Zurlo G, Fan C, Ptacek TS, Herring L, Tan X, Li M, Baldwin AS, Kim WY, Wu T, Kirschner MW, et al. Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss. Molecular Cell. PMID 32023483 DOI: 10.1016/J.Molcel.2020.01.009  0.305
2020 Mugahid D, Kalocsay M, Liu X, Gruver JS, Peshkin L, Kirschner MW. YAP regulates cell size and growth dynamics via non-cell autonomous mediators. Elife. 9. PMID 31913124 DOI: 10.7554/Elife.53404  0.327
2019 Peshkin L, Boukhali M, Haas W, Kirschner MW, Yampolsky LY. Quantitative Proteomics Reveals Remodeling of Protein Repertoire Across Life Phases of Daphnia Pulex. Proteomics. e1900155. PMID 31697011 DOI: 10.1002/Pmic.201900155  0.385
2019 Kim HM, Weber JA, Lee N, Park SG, Cho YS, Bhak Y, Lee N, Jeon Y, Jeon S, Luria V, Karger A, Kirschner MW, Jo YJ, Woo S, Shin K, et al. The genome of the giant Nomura's jellyfish sheds light on the early evolution of active predation. Bmc Biology. 17: 28. PMID 30925871 DOI: 10.1186/S12915-019-0643-7  0.709
2018 Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, ... ... Kirschner MW, et al. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science (New York, N.Y.). 361: 290-295. PMID 30026228 DOI: 10.1126/Science.Aap8411  0.356
2018 Ginzberg MB, Chang N, D'Souza H, Patel N, Kafri R, Kirschner MW. Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity. Elife. 7. PMID 29889021 DOI: 10.7554/Elife.26957  0.314
2018 Briggs JA, Weinreb C, Wagner DE, Megason S, Peshkin L, Kirschner MW, Klein AM. The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution. Science (New York, N.Y.). PMID 29700227 DOI: 10.1126/Science.Aar5780  0.796
2018 Liu S, Ginzberg MB, Patel N, Hild M, Leung B, Li Z, Chen YC, Chang N, Wang Y, Tan C, Diena S, Trimble W, Wasserman L, Jenkins JL, Kirschner MW, et al. Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length. Elife. 7. PMID 29595474 DOI: 10.7554/Elife.26947  0.31
2018 Darras S, Fritzenwanker JH, Uhlinger KR, Farrelly E, Pani AM, Hurley IA, Norris RP, Osovitz M, Terasaki M, Wu M, Aronowicz J, Kirschner M, Gerhart JC, Lowe CJ. Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development. Plos Biology. 16: e2003698. PMID 29337984 DOI: 10.1371/Journal.Pbio.2003698  0.787
2017 Presler M, Van Itallie E, Klein AM, Kunz R, Coughlin ML, Peshkin L, Gygi SP, Wühr M, Kirschner MW. Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg. Proceedings of the National Academy of Sciences of the United States of America. 114: E10838-E10847. PMID 29183978 DOI: 10.1073/Pnas.1709207114  0.801
2017 Briggs JA, Li VC, Lee S, Woolf CJ, Klein A, Kirschner MW. Mouse embryonic stem cells can differentiate via multiple paths to the same state. Elife. 6. PMID 28990928 DOI: 10.7554/Elife.26945  0.689
2017 Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantú AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, et al. Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates. Elife. 6. PMID 28885975 DOI: 10.7554/Elife.26509  0.795
2017 Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW. Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. Cell Reports. 20: 721-736. PMID 28723573 DOI: 10.1016/J.Celrep.2017.06.074  0.56
2017 Lu Y, Wu J, Dong Y, Chen S, Sun S, Ma YB, Ouyang Q, Finley D, Kirschner MW, Mao Y. Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Molecular Cell. PMID 28689658 DOI: 10.1016/J.Molcel.2017.06.007  0.368
2017 Gujral TS, Kirschner MW. Hippo pathway mediates resistance to cytotoxic drugs. Proceedings of the National Academy of Sciences of the United States of America. PMID 28416665 DOI: 10.1073/Pnas.1703096114  0.66
2017 Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, ... ... Kirschner MW, et al. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discovery. PMID 28174173 DOI: 10.1158/2159-8290.Cd-16-0647  0.445
2017 Briggs JA, Li VC, Lee S, Woolf CJ, Klein A, Kirschner MW. Author response: Mouse embryonic stem cells can differentiate via multiple paths to the same state Elife. DOI: 10.7554/Elife.26945.028  0.668
2017 Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantú AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, et al. Author response: Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates Elife. DOI: 10.7554/Elife.26509.034  0.733
2016 Chen S, Wu J, Lu Y, Ma YB, Lee BH, Yu Z, Ouyang Q, Finley DJ, Kirschner MW, Mao Y. Structural basis for dynamic regulation of the human 26S proteasome. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791164 DOI: 10.1073/Pnas.1614614113  0.417
2016 Brown NG, VanderLinden R, Watson ER, Weissmann F, Ordureau A, Wu KP, Zhang W, Yu S, Mercredi PY, Harrison JS, Davidson IF, Qiao R, Lu Y, Dube P, Brunner MR, ... ... Kirschner MW, et al. Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell. 165: 1440-1453. PMID 27259151 DOI: 10.1016/J.Cell.2016.05.037  0.38
2016 Berg JM, Bhalla N, Bourne PE, Chalfie M, Drubin DG, Fraser JS, Greider CW, Hendricks M, Jones C, Kiley R, King S, Kirschner MW, Krumholz HM, Lehmann R, Leptin M, et al. Preprints for the life sciences. Science (New York, N.Y.). 352: 899-901. PMID 27199406 DOI: 10.1126/Science.Aaf9133  0.658
2016 Hanschen ER, Marriage TN, Ferris PJ, Hamaji T, Toyoda A, Fujiyama A, Neme R, Noguchi H, Minakuchi Y, Suzuki M, Kawai-Toyooka H, Smith DR, Sparks H, Anderson J, Bakarić R, ... ... Kirschner MW, et al. The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity. Nature Communications. 7: 11370. PMID 27102219 DOI: 10.1038/Ncomms11370  0.743
2015 Lowe CJ, Terasaki M, Wu M, Freeman RM, Runft L, Kwan K, Haigo S, Aronowicz J, Lander E, Gruber C, Smith M, Kirschner M, Gerhart J. Correction: Dorsoventral Patterning in Hemichordates: Insights into Early Chordate Evolution. Plos Biology. 13: e1002354. PMID 26714185 DOI: 10.1371/Journal.Pbio.1002354  0.779
2015 Son S, Kang JH, Oh S, Kirschner MW, Mitchison TJ, Manalis S. Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis. The Journal of Cell Biology. 211: 757-63. PMID 26598613 DOI: 10.1083/Jcb.201505058  0.629
2015 Simakov O, Kawashima T, Marlétaz F, Jenkins J, Koyanagi R, Mitros T, Hisata K, Bredeson J, Shoguchi E, Gyoja F, Yue JX, Chen YC, Freeman RM, Sasaki A, Hikosaka-Katayama T, ... ... Kirschner MW, et al. Hemichordate genomes and deuterostome origins. Nature. PMID 26580012 DOI: 10.1038/Nature16150  0.771
2015 Peshkin L, Wühr M, Pearl E, Haas W, Freeman RM, Gerhart JC, Klein AM, Horb M, Gygi SP, Kirschner MW. On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development. Developmental Cell. 35: 383-94. PMID 26555057 DOI: 10.1016/J.Devcel.2015.10.010  0.79
2015 Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ, Kirschner MW, Gygi SP. The Nuclear Proteome of a Vertebrate. Current Biology : Cb. 25: 2663-71. PMID 26441354 DOI: 10.1016/J.Cub.2015.08.047  0.793
2015 Klein AM, Mazutis L, Akartuna I, Tallapragada N, Veres A, Li V, Peshkin L, Weitz DA, Kirschner MW. Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell. 161: 1187-201. PMID 26000487 DOI: 10.1016/J.Cell.2015.04.044  0.699
2015 Lu Y, Lee BH, King RW, Finley D, Kirschner MW. Substrate degradation by the proteasome: a single-molecule kinetic analysis. Science (New York, N.Y.). 348: 1250834. PMID 25859050 DOI: 10.1126/Science.1250834  0.583
2015 Lu Y, Wang W, Kirschner MW. Specificity of the anaphase-promoting complex: a single-molecule study. Science (New York, N.Y.). 348: 1248737. PMID 25859049 DOI: 10.1126/Science.1248737  0.413
2014 Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 159: 844-56. PMID 25417160 DOI: 10.1016/J.Cell.2014.10.032  0.733
2014 Zhao R, Deibler RW, Lerou PH, Ballabeni A, Heffner GC, Cahan P, Unternaehrer JJ, Kirschner MW, Daley GQ. A nontranscriptional role for Oct4 in the regulation of mitotic entry. Proceedings of the National Academy of Sciences of the United States of America. 111: 15768-73. PMID 25324523 DOI: 10.1073/Pnas.1417518111  0.382
2014 Satoh N, Tagawa K, Lowe CJ, Yu JK, Kawashima T, Takahashi H, Ogasawara M, Kirschner M, Hisata K, Su YH, Gerhart J. On a possible evolutionary link of the stomochord of hemichordates to pharyngeal organs of chordates. Genesis (New York, N.Y. : 2000). 52: 925-34. PMID 25303744 DOI: 10.1002/Dvg.22831  0.781
2014 Wang W, Wu T, Kirschner MW. The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium. Elife. 3: e03083. PMID 25139956 DOI: 10.7554/Elife.03083  0.396
2014 Merbl Y, Kirschner MW. Post-Translational Modification Profiling-a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. 77: 27.8.1-27.8.13. PMID 25081743 DOI: 10.1002/0471140864.Ps2708S77  0.704
2014 Li VC, Kirschner MW. Molecular ties between the cell cycle and differentiation in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 9503-8. PMID 24979803 DOI: 10.1073/Pnas.1408638111  0.528
2014 Wühr M, Freeman RM, Presler M, Horb ME, Peshkin L, Gygi SP, Kirschner MW. Deep proteomics of the Xenopus laevis egg using an mRNA-derived reference database. Current Biology : Cb. 24: 1467-75. PMID 24954049 DOI: 10.1016/J.Cub.2014.05.044  0.79
2014 Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W. APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction. Developmental Cell. 29: 377-91. PMID 24871945 DOI: 10.1016/J.Devcel.2014.04.022  0.344
2014 Gujral TS, Peshkin L, Kirschner MW. Exploiting polypharmacology for drug target deconvolution. Proceedings of the National Academy of Sciences of the United States of America. 111: 5048-53. PMID 24707051 DOI: 10.1073/Pnas.1403080111  0.669
2014 Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, ... ... Kirschner MW, et al. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 508: 541-5. PMID 24670654 DOI: 10.1038/Nature13079  0.586
2014 Ortiz-Meoz RF, Merbl Y, Kirschner MW, Walker S. Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated. Journal of the American Chemical Society. 136: 4845-8. PMID 24580054 DOI: 10.1021/Ja500451W  0.684
2014 Wang W, Wu T, Kirschner MW. Author response: The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium Elife. DOI: 10.7554/Elife.03083.019  0.327
2013 Kirschner M. Beyond Darwin: Evolvability and the generation of novelty Bmc Biology. 11. PMID 24228732 DOI: 10.1186/1741-7007-11-110  0.311
2013 Sung Y, Tzur A, Oh S, Choi W, Li V, Dasari RR, Yaqoob Z, Kirschner MW. Size homeostasis in adherent cells studied by synthetic phase microscopy. Proceedings of the National Academy of Sciences of the United States of America. 110: 16687-92. PMID 24065823 DOI: 10.1073/Pnas.1315290110  0.512
2013 Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W. SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Reports. 4: 803-16. PMID 23972993 DOI: 10.1016/J.Celrep.2013.07.031  0.612
2013 Ballabeni A, Zamponi R, Moore JK, Helin K, Kirschner MW. Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proceedings of the National Academy of Sciences of the United States of America. 110: E2848-53. PMID 23836640 DOI: 10.1073/Pnas.1310677110  0.343
2013 Wang W, Kirschner MW. Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex. Nature Cell Biology. 15: 797-806. PMID 23708001 DOI: 10.1038/Ncb2755  0.31
2013 Gallop JL, Walrant A, Cantley LC, Kirschner MW. Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9. Proceedings of the National Academy of Sciences of the United States of America. 110: 7193-8. PMID 23589871 DOI: 10.1073/Pnas.1305286110  0.494
2013 Merbl Y, Refour P, Patel H, Springer M, Kirschner MW. Profiling of ubiquitin-like modifications reveals features of mitotic control. Cell. 152: 1160-72. PMID 23452859 DOI: 10.1016/J.Cell.2013.02.007  0.768
2013 Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW. Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature. 494: 480-3. PMID 23446419 DOI: 10.1038/Nature11897  0.307
2013 Xie Y, Avello M, Schirle M, McWhinnie E, Feng Y, Bric-Furlong E, Wilson C, Nathans R, Zhang J, Kirschner MW, Huang SM, Cong F. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. The Journal of Biological Chemistry. 288: 2976-85. PMID 23184937 DOI: 10.1074/Jbc.M112.430066  0.384
2012 Hernández AR, Klein AM, Kirschner MW. Kinetic responses of β-catenin specify the sites of Wnt control. Science (New York, N.Y.). 338: 1337-40. PMID 23138978 DOI: 10.1126/Science.1228734  0.614
2012 Wühr M, Haas W, McAlister GC, Peshkin L, Rad R, Kirschner MW, Gygi SP. Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster. Analytical Chemistry. 84: 9214-21. PMID 23098179 DOI: 10.1021/Ac301962S  0.757
2012 Freeman R, Ikuta T, Wu M, Koyanagi R, Kawashima T, Tagawa K, Humphreys T, Fang GC, Fujiyama A, Saiga H, Lowe C, Worley K, Jenkins J, Schmutz J, Kirschner M, et al. Identical genomic organization of two hemichordate hox clusters. Current Biology : Cb. 22: 2053-8. PMID 23063438 DOI: 10.1016/J.Cub.2012.08.052  0.767
2012 Son S, Tzur A, Weng Y, Jorgensen P, Kim J, Kirschner MW, Manalis SR. Direct observation of mammalian cell growth and size regulation. Nature Methods. 9: 910-2. PMID 22863882 DOI: 10.1038/Nmeth.2133  0.301
2012 Li VC, Ballabeni A, Kirschner MW. Gap 1 phase length and mouse embryonic stem cell self-renewal. Proceedings of the National Academy of Sciences of the United States of America. 109: 12550-5. PMID 22802651 DOI: 10.1073/Pnas.1206740109  0.531
2011 Ballabeni A, Park IH, Zhao R, Wang W, Lerou PH, Daley GQ, Kirschner MW. Cell cycle adaptations of embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 19252-7. PMID 22084091 DOI: 10.1073/Pnas.1116794108  0.358
2011 Ali F, Hindley C, McDowell G, Deibler R, Jones A, Kirschner M, Guillemot F, Philpott A. Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis. Development (Cambridge, England). 138: 4267-77. PMID 21852393 DOI: 10.1242/Dev.067900  0.725
2011 Yanai I, Peshkin L, Jorgensen P, Kirschner MW. Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility. Developmental Cell. 20: 483-96. PMID 21497761 DOI: 10.1016/J.Devcel.2011.03.015  0.306
2011 Vastag L, Jorgensen P, Peshkin L, Wei R, Rabinowitz JD, Kirschner MW. Remodeling of the metabolome during early frog development. Plos One. 6: e16881. PMID 21347444 DOI: 10.1371/Journal.Pone.0016881  0.343
2011 Darras S, Gerhart J, Terasaki M, Kirschner M, Lowe CJ. β-catenin specifies the endomesoderm and defines the posterior organizer of the hemichordate Saccoglossus kowalevskii. Development (Cambridge, England). 138: 959-70. PMID 21303849 DOI: 10.1242/Dev.059493  0.789
2011 Merbl Y, Kirschner MW. Protein microarrays for genome-wide posttranslational modification analysis. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 3: 347-56. PMID 20865779 DOI: 10.1002/Wsbm.120  0.701
2010 Kirschner M. Cell biology as a world view Molecular Biology of the Cell. 21: 3803. PMID 21079019 DOI: 10.1091/Mbc.E10-04-0343  0.313
2010 Wu S, Wang W, Kong X, Congdon LM, Yokomori K, Kirschner MW, Rice JC. Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes & Development. 24: 2531-42. PMID 20966048 DOI: 10.1101/Gad.1984210  0.36
2010 Lee K, Gallop JL, Rambani K, Kirschner MW. Self-assembly of filopodia-like structures on supported lipid bilayers. Science (New York, N.Y.). 329: 1341-5. PMID 20829485 DOI: 10.1126/Science.1191710  0.325
2010 Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape M. The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes & Development. 24: 1434-47. PMID 20595234 DOI: 10.1101/Gad.1925010  0.634
2010 Springer M, Weissman JS, Kirschner MW. A general lack of compensation for gene dosage in yeast. Molecular Systems Biology. 6: 368. PMID 20461075 DOI: 10.1038/Msb.2010.19  0.538
2010 DeLuna A, Springer M, Kirschner MW, Kishony R. Need-based up-regulation of protein levels in response to deletion of their duplicate genes. Plos Biology. 8: e1000347. PMID 20361019 DOI: 10.1371/Journal.Pbio.1000347  0.56
2010 Deibler RW, Kirschner MW. Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts. Molecular Cell. 37: 753-67. PMID 20347419 DOI: 10.1016/J.Molcel.2010.02.023  0.366
2010 Wu T, Merbl Y, Huo Y, Gallop JL, Tzur A, Kirschner MW. UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. Proceedings of the National Academy of Sciences of the United States of America. 107: 1355-60. PMID 20080579 DOI: 10.1073/Pnas.0912802107  0.685
2009 Lebensohn AM, Kirschner MW. Activation of the WAVE complex by coincident signals controls actin assembly. Molecular Cell. 36: 512-24. PMID 19917258 DOI: 10.1016/J.Molcel.2009.10.024  0.754
2009 Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, ... ... Kirschner MW, et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature. 461: 614-20. PMID 19759537 DOI: 10.1038/Nature08356  0.313
2009 Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, Kirschner M, Dyson N, Wei W. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Molecular Biology of the Cell. 20: 3305-16. PMID 19477924 DOI: 10.1091/Mbc.E09-01-0092  0.35
2009 Jorgensen P, Steen JA, Steen H, Kirschner MW. The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus. Development (Cambridge, England). 136: 1539-48. PMID 19363155 DOI: 10.1242/Dev.032425  0.562
2009 Singh S, Springer M, Steen J, Kirschner MW, Steen H. FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. Journal of Proteome Research. 8: 2201-10. PMID 19344176 DOI: 10.1021/Pr800654S  0.668
2009 Merbl Y, Kirschner MW. Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays. Proceedings of the National Academy of Sciences of the United States of America. 106: 2543-8. PMID 19181856 DOI: 10.1073/Pnas.0812892106  0.717
2008 Freeman RM, Wu M, Cordonnier-Pratt MM, Pratt LH, Gruber CE, Smith M, Lander ES, Stange-Thomann N, Lowe CJ, Gerhart J, Kirschner M. cDNA sequences for transcription factors and signaling proteins of the hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence tag (EST) approach for evolutionary and developmental studies of a new organism. The Biological Bulletin. 214: 284-302. PMID 18574105  0.779
2008 Steen JA, Steen H, Georgi A, Parker K, Springer M, Kirchner M, Hamprecht F, Kirschner MW. Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis. Proceedings of the National Academy of Sciences of the United States of America. 105: 6069-74. PMID 18420821 DOI: 10.1073/Pnas.0709807104  0.653
2007 Milo R, Hou JH, Springer M, Brenner MP, Kirschner MW. The relationship between evolutionary and physiological variation in hemoglobin. Proceedings of the National Academy of Sciences of the United States of America. 104: 16998-7003. PMID 17942680 DOI: 10.1073/Pnas.0707673104  0.486
2007 Rickmyre JL, Dasgupta S, Ooi DL, Keel J, Lee E, Kirschner MW, Waddell S, Lee LA. The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. Journal of Cell Science. 120: 3565-77. PMID 17895362 DOI: 10.1242/Jcs.016626  0.341
2007 Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. An actin-based wave generator organizes cell motility. Plos Biology. 5: e221. PMID 17696648 DOI: 10.1371/Journal.Pbio.0050221  0.626
2007 Gerhart J, Kirschner M. The theory of facilitated variation. Proceedings of the National Academy of Sciences of the United States of America. 104: 8582-9. PMID 17494755 DOI: 10.1073/Pnas.0701035104  0.656
2007 Reddy SK, Rape M, Margansky WA, Kirschner MW. Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature. 446: 921-5. PMID 17443186 DOI: 10.1038/Nature05734  0.743
2007 Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature. 446: 876-81. PMID 17443180 DOI: 10.1038/Nature05694  0.654
2007 Wang R, He G, Nelman-Gonzalez M, Ashorn CL, Gallick GE, Stukenberg PT, Kirschner MW, Kuang J. Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell. 128: 1119-32. PMID 17382881 DOI: 10.1016/J.Cell.2006.11.053  0.626
2007 Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities Nature. 447: 876-881.  0.579
2006 Lowe CJ, Terasaki M, Wu M, Freeman RM, Runft L, Kwan K, Haigo S, Aronowicz J, Lander E, Gruber C, Smith M, Kirschner M, Gerhart J. Dorsoventral patterning in hemichordates: insights into early chordate evolution. Plos Biology. 4: e291. PMID 16933975 DOI: 10.1371/Journal.Pbio.0040291  0.796
2006 Peterson JR, Lebensohn AM, Pelish HE, Kirschner MW. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chemistry & Biology. 13: 443-52. PMID 16632257 DOI: 10.1016/J.Chembiol.2006.02.009  0.759
2006 Ho HY, Rohatgi R, Lebensohn AM, Kirschner MW. In vitro reconstitution of cdc42-mediated actin assembly using purified components. Methods in Enzymology. 406: 174-90. PMID 16472658 DOI: 10.1016/S0076-6879(06)06014-9  0.803
2006 Lebensohn AM, Ma L, Ho HY, Kirschner MW. Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts. Methods in Enzymology. 406: 156-73. PMID 16472657 DOI: 10.1016/S0076-6879(06)06013-7  0.79
2006 Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. Plos Biology. 4: e38. PMID 16417406 DOI: 10.1371/Journal.Pbio.0040038  0.784
2006 Rape M, Reddy SK, Kirschner MW. The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell. 124: 89-103. PMID 16413484 DOI: 10.1016/J.Cell.2005.10.032  0.704
2006 Steen H, Jebanathirajah JA, Rush J, Morrice N, Kirschner MW. Phosphorylation analysis by mass spectrometry: myths, facts, and the consequences for qualitative and quantitative measurements. Molecular & Cellular Proteomics : McP. 5: 172-81. PMID 16204703 DOI: 10.1074/Mcp.M500135-Mcp200  0.489
2006 Kirschner MW, Walter JC. In Memoriam: John Newport (1951–2005) Developmental Cell. 10: 287-289. DOI: 10.1016/J.Devcel.2006.02.014  0.497
2006 Kirschner MW, Walter JC. John Newport 1951–2005 Cell. 124: 453-454. DOI: 10.1016/J.Cell.2006.01.024  0.497
2005 Ayad NG, Rankin S, Ooi D, Rape M, Kirschner MW. Identification of ubiquitin ligase substrates by in vitro expression cloning. Methods in Enzymology. 399: 404-14. PMID 16338372 DOI: 10.1016/S0076-6879(05)99028-9  0.602
2005 Jebanathirajah JA, Pittman JL, Thomson BA, Budnik BA, Kaur P, Rape M, Kirschner M, Costello CE, O'Connor PB. Characterization of a new qQq-FTICR mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins. Journal of the American Society For Mass Spectrometry. 16: 1985-99. PMID 16271296 DOI: 10.1016/J.Jasms.2005.08.008  0.604
2005 Kwan KM, Kirschner MW. A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis. Development (Cambridge, England). 132: 4599-610. PMID 16176947 DOI: 10.1242/Dev.02041  0.686
2005 Gerhart J, Lowe C, Kirschner M. Hemichordates and the origin of chordates. Current Opinion in Genetics & Development. 15: 461-7. PMID 15964754 DOI: 10.1016/J.Gde.2005.06.004  0.772
2005 Rankin S, Ayad NG, Kirschner MW. Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Molecular Cell. 18: 185-200. PMID 15837422 DOI: 10.1016/J.Molcel.2005.03.017  0.402
2005 Steen H, Jebanathirajah JA, Springer M, Kirschner MW. Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS. Proceedings of the National Academy of Sciences of the United States of America. 102: 3948-53. PMID 15741271 DOI: 10.1073/Pnas.0409536102  0.647
2005 Lee LA, Lee E, Anderson MA, Vardy L, Tahinci E, Ali SM, Kashevsky H, Benasutti M, Kirschner MW, Orr-Weaver TL. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Developmental Cell. 8: 435-42. PMID 15737938 DOI: 10.1016/J.Devcel.2004.12.008  0.381
2005 Rankin S, Ayad NG, Kirschner MW. Erratum: Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates (Mulecular Cell 18 (185-200)) Molecular Cell. 18. DOI: 10.1016/J.Molcel.2005.05.004  0.33
2005 Kirschner MW, Gerhart JC. The plausibility of life: Resolving Darwin's Dilemma The Plausibility of Life: Resolving Darwin's Dilemma. 1-314.  0.595
2004 Lowe CJ, Tagawa K, Humphreys T, Kirschner M, Gerhart J. Hemichordate embryos: procurement, culture, and basic methods. Methods in Cell Biology. 74: 171-94. PMID 15575607 DOI: 10.1016/S0091-679X(04)74008-X  0.776
2004 Rape M, Kirschner MW. Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature. 432: 588-95. PMID 15558010 DOI: 10.1038/Nature03023  0.645
2004 Margalit DN, Romberg L, Mets RB, Hebert AM, Mitchison TJ, Kirschner MW, RayChaudhuri D. Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proceedings of the National Academy of Sciences of the United States of America. 101: 11821-6. PMID 15289600 DOI: 10.1073/Pnas.0404439101  0.637
2004 Ho HY, Rohatgi R, Lebensohn AM, Le Ma, Li J, Gygi SP, Kirschner MW. Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell. 118: 203-16. PMID 15260990 DOI: 10.1016/J.Cell.2004.06.027  0.796
2004 Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nature Structural & Molecular Biology. 11: 747-55. PMID 15235593 DOI: 10.1038/Nsmb796  0.309
2004 Martinez-Quiles N, Ho HY, Kirschner MW, Ramesh N, Geha RS. Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Molecular and Cellular Biology. 24: 5269-80. PMID 15169891 DOI: 10.1128/Mcb.24.12.5269-5280.2004  0.311
2004 Gautreau A, Ho HY, Li J, Steen H, Gygi SP, Kirschner MW. Purification and architecture of the ubiquitous Wave complex. Proceedings of the National Academy of Sciences of the United States of America. 101: 4379-83. PMID 15070726 DOI: 10.1073/Pnas.0400628101  0.595
2004 Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature. 428: 194-8. PMID 15014503 DOI: 10.1038/Nature02381  0.371
2004 Campellone KG, Rankin S, Pawson T, Kirschner MW, Tipper DJ, Leong JM. Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. The Journal of Cell Biology. 164: 407-16. PMID 14757753 DOI: 10.1083/Jcb.200306032  0.379
2004 Song MS, Song SJ, Ayad NG, Chang JS, Lee JH, Hong HK, Lee H, Choi N, Kim J, Kim H, Kim JW, Choi EJ, Kirschner MW, Lim DS. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nature Cell Biology. 6: 129-37. PMID 14743218 DOI: 10.1038/Ncb1091  0.383
2004 Margalit DN, Romberg L, Mets RB, Hebert AM, Mitchison TJ, Kirschner MW, RayChaudhuri D. Erratum: Targeting cell division: Small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality (Proceedings of the National Academy of Sciences of the United States of America (August 10, 2004) 101, 32 (11821-11826)) Proceedings of the National Academy of Sciences of the United States of America. 101. DOI: 10.1073/Pnas.0405755101  0.601
2003 Lee E, Salic A, Krüger R, Heinrich R, Kirschner MW. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. Plos Biology. 1: E10. PMID 14551908 DOI: 10.1371/Journal.Pbio.0000010  0.679
2003 Yan C, Martinez-Quiles N, Eden S, Shibata T, Takeshima F, Shinkura R, Fujiwara Y, Bronson R, Snapper SB, Kirschner MW, Geha R, Rosen FS, Alt FW. WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. The Embo Journal. 22: 3602-12. PMID 12853475 DOI: 10.1093/Emboj/Cdg350  0.301
2003 Lowe CJ, Wu M, Salic A, Evans L, Lander E, Stange-Thomann N, Gruber CE, Gerhart J, Kirschner M. Anteroposterior patterning in hemichordates and the origins of the chordate nervous system. Cell. 113: 853-65. PMID 12837244 DOI: 10.1016/S0092-8674(03)00469-0  0.769
2003 Gerber SA, Rush J, Stemman O, Kirschner MW, Gygi SP. Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proceedings of the National Academy of Sciences of the United States of America. 100: 6940-5. PMID 12771378 DOI: 10.1073/Pnas.0832254100  0.499
2003 Ayad NG, Rankin S, Murakami M, Jebanathirajah J, Gygi S, Kirschner MW. Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell. 113: 101-13. PMID 12679038 DOI: 10.1016/S0092-8674(03)00232-0  0.485
2003 Chabes AL, Pfleger CM, Kirschner MW, Thelander L. Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 3925-9. PMID 12655059 DOI: 10.1073/Pnas.0330774100  0.32
2003 Kwan KM, Kirschner MW. Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula. Development (Cambridge, England). 130: 1961-72. PMID 12642499 DOI: 10.1242/Dev.00412  0.661
2003 Collavin L, Kirschner MW. The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm. Development (Cambridge, England). 130: 805-16. PMID 12506010 DOI: 10.1242/Dev.00306  0.358
2002 Zhu Z, Kirschner M. Regulated Proteolysis of Xom Mediates Dorsoventral Pattern Formation during Early Xenopus Development Developmental Cell. 3: 557-568. PMID 12408807 DOI: 10.1016/S1534-5807(02)00270-8  0.379
2002 Zou H, Stemman O, Anderson JS, Mann M, Kirschner MW. Anaphase specific auto-cleavage of separase. Febs Letters. 528: 246-50. PMID 12297314 DOI: 10.1016/S0014-5793(02)03238-6  0.449
2002 Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature. 418: 790-3. PMID 12181570 DOI: 10.1038/Nature00859  0.634
2002 Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO. A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. The Journal of Biological Chemistry. 277: 34727-35. PMID 12121999 DOI: 10.1074/Jbc.M204989200  0.662
2002 Farhana L, Dawson M, Rishi AK, Zhang Y, Van Buren E, Trivedi C, Reichert U, Fang G, Kirschner MW, Fontana JA. Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway. Cancer Research. 62: 3842-9. PMID 12097298  0.607
2002 Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nature Cell Biology. 4: 509-13. PMID 12080346 DOI: 10.1038/Ncb811  0.73
2002 Georgi AB, Stukenberg PT, Kirschner MW. Timing of events in mitosis. Current Biology : Cb. 12: 105-14. PMID 11818060 DOI: 10.1016/S0960-9822(01)00662-5  0.652
2002 Zou H, Stemmann O, Anderson JS, Mann M, Kirschner MW. Corrigendum to: Anaphase specific auto-cleavage of separase (FEBS 26464) Febs Letters. 531: 381-381. DOI: 10.1016/S0014-5793(02)03547-0  0.423
2001 Stemmann O, Zou H, Gerber SA, Gygi SP, Kirschner MW. Dual inhibition of sister chromatid separation at metaphase. Cell. 107: 715-26. PMID 11747808 DOI: 10.1016/S0092-8674(01)00603-1  0.489
2001 Davis RL, Turner DL, Evans LM, Kirschner MW. Molecular targets of vertebrate segmentation: two mechanisms control segmental expression of Xenopus hairy2 during somite formation. Developmental Cell. 1: 553-65. PMID 11703945 DOI: 10.1016/S1534-5807(01)00054-5  0.307
2001 Wan Y, Kirschner MW. Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities. Proceedings of the National Academy of Sciences of the United States of America. 98: 13066-71. PMID 11687641 DOI: 10.1073/Pnas.231487598  0.392
2001 Pfleger CM, Lee E, Kirschner MW. Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes & Development. 15: 2396-407. PMID 11562349 DOI: 10.1101/Gad.918201  0.336
2001 Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proceedings of the National Academy of Sciences of the United States of America. 98: 10624-9. PMID 11553809 DOI: 10.1073/Pnas.201393198  0.756
2001 Ho HY, Rohatgi R, Ma L, Kirschner MW. CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family. Proceedings of the National Academy of Sciences of the United States of America. 98: 11306-11. PMID 11553796 DOI: 10.1073/Pnas.211420498  0.677
2001 Lee E, Salic A, Kirschner MW. Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon. The Journal of Cell Biology. 154: 983-93. PMID 11524435 DOI: 10.1083/Jcb.200102074  0.659
2001 Pfleger CM, Salic A, Lee E, Kirschner MW. Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1. Genes & Development. 15: 1759-64. PMID 11459825 DOI: 10.1101/Gad.897901  0.709
2001 Stukenberg PT, Kirschner MW. Pin1 acts catalytically to promote a conformational change in Cdc25. Molecular Cell. 7: 1071-83. PMID 11389853 DOI: 10.1016/S1097-2765(01)00245-3  0.642
2001 Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ. Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. The Journal of Biological Chemistry. 276: 26448-52. PMID 11340081 DOI: 10.1074/Jbc.M103856200  0.601
2001 Roberts RJ, Varmus HE, Ashburner M, Brown PO, Eisen MB, Khosla C, Kirschner M, Nusse R, Scott M, Wold B. Information access. Building a "GenBank" of the published literature. Science (New York, N.Y.). 291: 2318-9. PMID 11269300 DOI: 10.1126/Science.1060273  0.45
2000 Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA. LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron. 28: 665-79. PMID 11163258 DOI: 10.1016/S0896-6273(00)00145-8  0.652
2000 Yamaguchi H, Miki H, Suetsugu S, Ma L, Kirschner MW, Takenawa T. Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP. Proceedings of the National Academy of Sciences of the United States of America. 97: 12631-6. PMID 11058146 DOI: 10.1073/Pnas.190351397  0.538
2000 Rohatgi R, Ho HY, Kirschner MW. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. The Journal of Cell Biology. 150: 1299-310. PMID 10995436 DOI: 10.1083/Jcb.150.6.1299  0.586
2000 Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Current Biology : Cb. 10: 758-65. PMID 10898977 DOI: 10.1016/S0960-9822(00)00571-6  0.603
2000 Salic A, Lee E, Mayer L, Kirschner MW. Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Molecular Cell. 5: 523-32. PMID 10882137 DOI: 10.1016/S1097-2765(00)80446-3  0.66
2000 Pfleger CM, Kirschner MW. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes & Development. 14: 655-65. PMID 10733526 DOI: 10.1101/Gad.14.6.655  0.39
2000 Luo X, Fang G, Coldiron M, Lin Y, Yu H, Kirschner MW, Wagner G. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Nature Structural Biology. 7: 224-9. PMID 10700282 DOI: 10.1038/73338  0.655
1999 Kroll KL, Kirschner MW. Easy passage: germline transgenesis in frogs. Proceedings of the National Academy of Sciences of the United States of America. 96: 14189-90. PMID 10588674 DOI: 10.1073/Pnas.96.25.14189  0.785
1999 Fang G, Yu H, Kirschner MW. Control of mitotic transitions by the anaphase-promoting complex. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 354: 1583-90. PMID 10582244 DOI: 10.1098/Rstb.1999.0502  0.688
1999 Zou H, McGarry TJ, Bernal T, Kirschner MW. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science (New York, N.Y.). 285: 418-22. PMID 10411507 DOI: 10.1126/Science.285.5426.418  0.391
1999 Zhou BB, Kirschner MW. Quantitative measurement of the catastrophe rate of dynamic microtubules. Cell Motility and the Cytoskeleton. 43: 43-51. PMID 10340702 DOI: 10.1002/(Sici)1097-0169(1999)43:1<43::Aid-Cm5>3.0.Co;2-A  0.325
1999 Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 97: 221-31. PMID 10219243 DOI: 10.1016/S0092-8674(00)80732-1  0.686
1999 Philpott A, Tsai L, Kirschner MW. Neuronal differentiation and patterning in Xenopus: the role of cdk5 and a novel activator xp35.2. Developmental Biology. 207: 119-32. PMID 10049569 DOI: 10.1006/Dbio.1998.9146  0.576
1998 Ma L, Rohatgi R, Kirschner MW. The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42. Proceedings of the National Academy of Sciences of the United States of America. 95: 15362-7. PMID 9860974 DOI: 10.1073/Pnas.95.26.15362  0.708
1998 Sif S, Stukenberg PT, Kirschner MW, Kingston RE. Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. Genes & Development. 12: 2842-51. PMID 9744861  0.62
1998 Mead PE, Zhou Y, Lustig KD, Huber TL, Kirschner MW, Zon LI. Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 95: 11251-6. PMID 9736722 DOI: 10.1073/Pnas.95.19.11251  0.352
1998 Fang G, Yu H, Kirschner MW. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Molecular Cell. 2: 163-71. PMID 9734353 DOI: 10.1016/S1097-2765(00)80126-4  0.674
1998 Kroll KL, Salic AN, Evans LM, Kirschner MW. Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. Development (Cambridge, England). 125: 3247-58. PMID 9671596  0.785
1998 Fang G, Yu H, Kirschner MW. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes & Development. 12: 1871-83. PMID 9637688 DOI: 10.1101/Gad.12.12.1871  0.696
1998 McGarry TJ, Kirschner MW. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell. 93: 1043-53. PMID 9635433 DOI: 10.1016/S0092-8674(00)81209-X  0.302
1998 Zhou BB, Li H, Yuan J, Kirschner MW. Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 6785-90. PMID 9618490 DOI: 10.1073/Pnas.95.12.6785  0.318
1998 Shen M, Stukenberg PT, Kirschner MW, Lu KP. The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes & Development. 12: 706-20. PMID 9499405 DOI: 10.1101/Gad.12.5.706  0.657
1998 Ma L, Cantley LC, Janmey PA, Kirschner MW. Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts. The Journal of Cell Biology. 140: 1125-36. PMID 9490725 DOI: 10.1083/Jcb.140.5.1125  0.638
1998 Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science (New York, N.Y.). 279: 1219-22. PMID 9469815 DOI: 10.1126/Science.279.5354.1219  0.609
1998 Wray GA, Gerhart J, Kirschner M. A Touch Cell Evolution. 52: 291. DOI: 10.2307/2410949  0.732
1997 Yamashita YM, Peters JM, King RW, Höög C, Kirschner MW, Zachariae W, Shin TH, Galova M, Obermaier B, Nasmyth K. BIME joins the destruction team. Trends in Cell Biology. 7: 49. PMID 17708905 DOI: 10.1016/S0962-8924(97)82669-4  0.417
1997 Forreiter C, Kirschner M, Nover L. Stable transformation of an Arabidopsis cell suspension culture with firefly luciferase providing a cellular system for analysis of chaperone activity in vivo. The Plant Cell. 9: 2171-81. PMID 9437862 DOI: 10.1105/Tpc.9.12.2171  0.306
1997 Salic AN, Kroll KL, Evans LM, Kirschner MW. Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos. Development (Cambridge, England). 124: 4739-48. PMID 9428410  0.791
1997 Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science (New York, N.Y.). 278: 1957-60. PMID 9395400 DOI: 10.1126/Science.278.5345.1957  0.685
1997 Cryns VL, Byun Y, Rana A, Mellor H, Lustig KD, Ghanem L, Parker PJ, Kirschner MW, Yuan J. Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy. The Journal of Biological Chemistry. 272: 29449-53. PMID 9368003 DOI: 10.1074/Jbc.272.47.29449  0.324
1997 Yew PR, Kirschner MW. Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle. Science (New York, N.Y.). 277: 1672-6. PMID 9287222 DOI: 10.1126/Science.277.5332.1672  0.37
1997 King RW, Lustig KD, Stukenberg PT, McGarry TJ, Kirschner MW. Expression cloning in the test tube. Science (New York, N.Y.). 277: 973-4. PMID 9281074 DOI: 10.1126/Science.277.5328.973  0.711
1997 Lustig KD, Stukenberg PT, McGarry TJ, King RW, Cryns VL, Mead PE, Zon LI, Yuan J, Kirschner MW. Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development. Methods in Enzymology. 283: 83-99. PMID 9251013 DOI: 10.1016/S0076-6879(97)83009-1  0.721
1997 Rankin S, Kirschner MW. The surface contraction waves of Xenopus eggs reflect the metachronous cell-cycle state of the cytoplasm. Current Biology : Cb. 7: 451-4. PMID 9197242 DOI: 10.1016/S0960-9822(06)00192-8  0.329
1997 Philpott A, Porro EB, Kirschner MW, Tsai LH. The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. Genes & Development. 11: 1409-21. PMID 9192869 DOI: 10.1101/Gad.11.11.1409  0.58
1997 Stukenberg PT, Lustig KD, McGarry TJ, King RW, Kuang J, Kirschner MW. Systematic identification of mitotic phosphoproteins. Current Biology : Cb. 7: 338-48. PMID 9115395 DOI: 10.1016/S0960-9822(06)00157-6  0.747
1996 Lustig KD, Kroll KL, Sun EE, Kirschner MW. Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation. Development (Cambridge, England). 122: 4001-12. PMID 9012520  0.782
1996 Cohen-Fix O, Peters JM, Kirschner MW, Koshland D. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes & Development. 10: 3081-93. PMID 8985178 DOI: 10.1101/Gad.10.24.3081  0.64
1996 King RW, Deshaies RJ, Peters JM, Kirschner MW. How proteolysis drives the cell cycle. Science (New York, N.Y.). 274: 1652-9. PMID 8939846 DOI: 10.1126/Science.274.5293.1652  0.719
1996 Peters JM, King RW, Höög C, Kirschner MW. Identification of BIME as a subunit of the anaphase-promoting complex. Science (New York, N.Y.). 274: 1199-201. PMID 8895470 DOI: 10.1126/Science.274.5290.1199  0.595
1996 King RW, Glotzer M, Kirschner MW. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. Molecular Biology of the Cell. 7: 1343-57. PMID 8885231 DOI: 10.1091/Mbc.7.9.1343  0.721
1996 Yu H, King RW, Peters JM, Kirschner MW. Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation. Current Biology : Cb. 6: 455-66. PMID 8723350 DOI: 10.1016/S0960-9822(02)00513-4  0.557
1996 Lee TH, Kirschner MW. An inhibitor of p34cdc2/cyclin B that regulates the G2/M transition in Xenopus extracts Proceedings of the National Academy of Sciences of the United States of America. 93: 352-356. PMID 8552637 DOI: 10.1073/Pnas.93.1.352  0.336
1995 Chen J, Jackson PK, Kirschner MW, Dutta A. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature. 374: 386-8. PMID 7885482 DOI: 10.1038/374386A0  0.515
1995 Deshaies RJ, Kirschner M. G1 cyclin-dependent activation of p34CDC28 (Cdc28p) in vitro. Proceedings of the National Academy of Sciences of the United States of America. 92: 1182-6. PMID 7862657 DOI: 10.1073/Pnas.92.4.1182  0.596
1995 Deshaies RJ, Chau V, Kirschner M. Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway. The Embo Journal. 14: 303-12. PMID 7835341 DOI: 10.1002/J.1460-2075.1995.Tb07004.X  0.596
1995 King RW, Peters JM, Tugendreich S, Rolfe M, Hieter P, Kirschner MW. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell. 81: 279-88. PMID 7736580 DOI: 10.1016/0092-8674(95)90338-0  0.598
1995 Brandli AW, Kirschner MW. Molecular cloning of tyrosine kinases in the early Xenopus embryo: Identification of Eck-related genes expressed in cranial neural crest cells of the second (hyoid) arch Developmental Dynamics. 203: 119-140. PMID 7655077 DOI: 10.1002/Aja.1002030202  0.334
1995 Jackson PK, Chevalier S, Philippe M, Kirschner MW. Early events in DNA replication require cyclin E and are blocked by p21CIP1. The Journal of Cell Biology. 130: 755-69. PMID 7642695 DOI: 10.1083/Jcb.130.4.755  0.532
1995 Lustig KD, Kirschner MW. Use of an oocyte expression assay to reconstitute inductive signaling Proceedings of the National Academy of Sciences of the United States of America. 92: 6234-6238. PMID 7541533 DOI: 10.1073/Pnas.92.14.6234  0.339
1994 Doxsey SJ, Stein P, Evans L, Calarco PD, Kirschner M. Pericentrin, a highly conserved centrosome protein involved in microtubule organization. Cell. 76: 639-50. PMID 8124707 DOI: 10.1016/0092-8674(94)90504-5  0.655
1994 Stearns T, Kirschner M. In vitro reconstitution of centrosome assembly and function: the central role of gamma-tubulin. Cell. 76: 623-37. PMID 8124706 DOI: 10.1016/0092-8674(94)90503-7  0.58
1994 Lee TH, Turck C, Kirschner MW. Inhibition of cdc2 activation by INH/PP2A Molecular Biology of the Cell. 5: 323-338. PMID 8049524 DOI: 10.1091/Mbc.5.3.323  0.344
1994 King RW, Jackson PK, Kirschner MW. Mitosis in transition. Cell. 79: 563-71. PMID 7954823 DOI: 10.1016/0092-8674(94)90542-8  0.601
1994 Drechsel DN, Kirschner MW. The minimum GTP cap required to stabilize microtubules Current Biology. 4: 1053-1061. PMID 7704569 DOI: 10.1016/S0960-9822(00)00243-8  0.323
1993 Booher RN, Deshaies RJ, Kirschner MW. Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. The Embo Journal. 12: 3417-26. PMID 8253069 DOI: 10.1002/J.1460-2075.1993.Tb06016.X  0.588
1992 Solomon MJ, Lee T, Kirschner MW. Role of phosphorylation in p34cdc2 activation: identification of an activating kinase. Molecular Biology of the Cell. 3: 13-27. PMID 1532335 DOI: 10.1091/Mbc.3.1.13  0.538
1992 Drechsel DN, Hyman AA, Cobb MH, Kirschner MW. Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau Molecular Biology of the Cell. 3: 1141-1154. PMID 1421571 DOI: 10.1091/Mbc.3.10.1141  0.529
1992 Kirschner M. The cell cycle then and now Trends in Biochemical Sciences. 17: 281-285. PMID 1412700 DOI: 10.1016/0968-0004(92)90435-C  0.388
1991 Butner KA, Kirschner MW. Tau protein binds to microtubules through a flexible array of distributed weak sites Journal of Cell Biology. 115: 717-730. PMID 1918161 DOI: 10.1083/Jcb.115.3.717  0.328
1991 Sabry JH, O'Connor TP, Evans L, Toroian-Raymond A, Kirschner M, Bentley D. Microtubule behavior during guidance of pioneer neuron growth cones in situ Journal of Cell Biology. 115: 381-395. PMID 1918146 DOI: 10.1083/Jcb.115.2.381  0.3
1991 Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell. 67: 197-211. PMID 1913817 DOI: 10.1016/0092-8674(91)90583-K  0.726
1991 Lee TH, Solomon MJ, Mumby MC, Kirschner MW. INH, a negative regulator of MPF, is a form of protein phosphatase 2A. Cell. 64: 415-23. PMID 1846321 DOI: 10.1016/0092-8674(91)90649-J  0.582
1991 Glotzer M, Murray AW, Kirschner MW. Cyclin is degraded by the ubiquitin pathway. Nature. 349: 132-8. PMID 1846030 DOI: 10.1038/349132A0  0.713
1991 Stearns T, Evans L, Kirschner M. Gamma-tubulin is a highly conserved component of the centrosome. Cell. 65: 825-36. PMID 1840506 DOI: 10.1016/0092-8674(91)90390-K  0.576
1991 Solomon MJ, Gautier J, Lee T, Kirschner MW. Control of p34cdc2 activation. Cold Spring Harbor Symposia On Quantitative Biology. 56: 427-35. PMID 1840256 DOI: 10.1101/Sqb.1991.056.01.050  0.649
1991 Murray AW, Kirschner MW. What controls the cell cycle? Scientific American. 264: 56-63. PMID 1828616 DOI: 10.1038/Scientificamerican0391-56  0.473
1991 Reinsch SS, Mitchison TJ, Kirschner M. Microtubule polymer assembly and transport during axonal elongation. The Journal of Cell Biology. 115: 365-79. PMID 1717484 DOI: 10.1083/Jcb.115.2.365  0.59
1991 Lundgren K, Walworth N, Booher R, Dembski M, Kirschner M, Beach D. mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell. 64: 1111-22. PMID 1706223 DOI: 10.1016/0092-8674(91)90266-2  0.329
1990 Mitchison T, Kirschner M. Cytoskeletal dynamics and nerve growth. Neuron. 1: 761-72. PMID 3078414 DOI: 10.1016/0896-6273(88)90124-9  0.568
1990 Ward GE, Kirschner MW. Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C Cell. 61: 561-577. PMID 2188730 DOI: 10.1016/0092-8674(90)90469-U  0.349
1990 Solomon MJ, Glotzer M, Lee TH, Philippe M, Kirschner MW. Cyclin activation of p34cdc2. Cell. 63: 1013-24. PMID 2147872 DOI: 10.1016/0092-8674(90)90504-8  0.731
1990 Steiner B, Mandelkow EM, Biernat J, Gustke N, Meyer HE, Schmidt B, Mieskes G, Söling HD, Drechsel D, Kirschner MW. Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles. The Embo Journal. 9: 3539-44. PMID 2120043 DOI: 10.1002/J.1460-2075.1990.Tb07563.X  0.339
1989 Murray AW, Kirschner MW. Dominoes and clocks: the union of two views of the cell cycle. Science (New York, N.Y.). 246: 614-21. PMID 2683077 DOI: 10.1126/Science.2683077  0.492
1989 Murray AW, Solomon MJ, Kirschner MW. The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature. 339: 280-6. PMID 2566918 DOI: 10.1038/339280A0  0.641
1989 Murray AW, Kirschner MW. Cyclin synthesis drives the early embryonic cell cycle. Nature. 339: 275-80. PMID 2566917 DOI: 10.1038/339275A0  0.529
1989 Himmler A, Drechsel D, Kirschner MW, Martin DW. Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains. Molecular and Cellular Biology. 9: 1381-8. PMID 2498649 DOI: 10.1128/Mcb.9.4.1381  0.329
1988 Gard DL, Kirschner MW. Microtubule assembly in cytoplasmic extracts of Xenopus oocytes and eggs. The Journal of Cell Biology. 105: 2191-201. PMID 3680377 DOI: 10.1083/Jcb.105.5.2191  0.333
1988 Schulze E, Kirschner M. New features of microtubule behaviour observed in vivo. Nature. 334: 356-359. PMID 3393227 DOI: 10.1038/334356A0  0.335
1988 Koshland DE, Mitchison TJ, Kirschner MW. Polewards chromosome movement driven by microtubule depolymerization in vitro. Nature. 331: 499-504. PMID 3340202 DOI: 10.1038/331499A0  0.716
1988 Huitorel P, Kirschner MW. The polarity and stability of microtubule capture by the kinetochore. The Journal of Cell Biology. 106: 151-9. PMID 3339086 DOI: 10.1083/Jcb.106.1.151  0.304
1988 Kimelman D, Abraham JA, Haaparanta T, Palisi TM, Kirschner MW. The presence of fibroblast growth factor in the frog egg: Its role as a natural mesoderm inducer Science. 242: 1053-1056. PMID 3194757 DOI: 10.1126/Science.3194757  0.359
1988 Drubin D, Kobayashi S, Kellogg D, Kirschner M. Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells. Journal of Cell Biology. 106: 1583-1591. PMID 3131347 DOI: 10.1083/Jcb.106.5.1583  0.322
1988 Lee G, Cowan N, Kirschner M. The primary structure and heterogeneity of tau protein from mouse brain. Science (New York, N.Y.). 239: 285-8. PMID 3122323 DOI: 10.1126/Science.3122323  0.324
1988 Cyert MS, Scherson T, Kirschner MW. Monoclonal antibodies specific for thiophosphorylated proteins recognize Xenopus MPF. Developmental Biology. 129: 209-16. PMID 3044877 DOI: 10.1016/0012-1606(88)90175-3  0.651
1988 Solomon M, Booher R, Kirschner M, Beach D. Cyclin in fission yeast Cell. 54: 738-740. PMID 2900688 DOI: 10.1016/S0092-8674(88)90933-6  0.527
1988 Gard DL, Kirschner MW. A microtubule-associated protein from Xenopus eggs that specifically promotes assembly at the plus-end. The Journal of Cell Biology. 105: 2203-15. PMID 2890645 DOI: 10.1083/Jcb.105.5.2203  0.387
1988 Cyert MS, Kirschner MW. Regulation of MPF activity in vitro. Cell. 53: 185-95. PMID 2834064 DOI: 10.1016/0092-8674(88)90380-7  0.685
1987 Karsenti E, Bravo R, Kirschner M. Phosphorylation changes associated with the early cell cycle in Xenopus eggs Developmental Biology. 119: 442-453. PMID 3803713 DOI: 10.1016/0012-1606(87)90048-0  0.587
1987 Kimelman D, Kirschner M, Scherson T. The events of the midblastula transition in Xenopus are regulated by changes in the cell cycle Cell. 48: 399-407. PMID 3802197 DOI: 10.1016/0092-8674(87)90191-7  0.358
1987 Schulze E, Kirschner M. Dynamic and stable populations of microtubules in cells. Journal of Cell Biology. 104: 277-288. PMID 3543024 DOI: 10.1083/Jcb.104.2.277  0.317
1987 Kimelman D, Kirschner M. Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo Cell. 51: 869-877. PMID 3479265 DOI: 10.1016/0092-8674(87)90110-3  0.308
1987 Wolin SL, Krohne G, Kirschner MW. A new lamin in Xenopus somatic tissues displays strong homology to human lamin A. The Embo Journal. 6: 3809-18. PMID 3428277 DOI: 10.1002/J.1460-2075.1987.Tb02717.X  0.351
1987 Krohne G, Wolin SL, McKeon FD, Franke WW, Kirschner MW. Nuclear lamin LI of Xenopus laevis: cDNA cloning, amino acid sequence and binding specificity of a member of the lamin B subfamily. The Embo Journal. 6: 3801-8. PMID 3428276 DOI: 10.1002/J.1460-2075.1987.Tb02716.X  0.558
1987 Schulze E, Asai DJ, Bulinski JC, Kirschner M. Posttranslational modification and microtubule stability. The Journal of Cell Biology. 105: 2167-77. PMID 3316248 DOI: 10.1083/Jcb.105.5.2167  0.349
1987 Drubin D, Kirschner M. Purification of tau protein from brain. Methods in Enzymology. 134: 156-60. PMID 3102900 DOI: 10.1016/0076-6879(86)34084-9  0.512
1987 Mitchison TJ, Kirschner MW. Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability. Cell Biophysics. 11: 35-55. PMID 2450668  0.567
1986 Mitchison TJ, Kirschner MW. Isolation of mammalian centrosomes. Methods in Enzymology. 134: 261-8. PMID 3821566 DOI: 10.1016/0076-6879(86)34094-1  0.525
1986 Caron JM, Kirschner MW. Autoregulation of tubulin synthesis Bioessays. 5: 211-216. PMID 3814112 DOI: 10.1002/Bies.950050506  0.315
1986 Mitchison T, Evans L, Schulze E, Kirschner M. Sites of microtubule assembly and disassembly in the mitotic spindle. Cell. 45: 515-527. PMID 3708686 DOI: 10.1016/0092-8674(86)90283-7  0.63
1986 Kirschner M, Mitchison T. Beyond self-assembly: from microtubules to morphogenesis. Cell. 45: 329-42. PMID 3516413 DOI: 10.1016/0092-8674(86)90318-1  0.588
1986 Schulze E, Kirschner M. Microtubule dynamics in interphase cells. Journal of Cell Biology. 102: 1020-1031. PMID 3512576 DOI: 10.1083/Jcb.102.3.1020  0.326
1986 Kirschner M, Schulze E. Morphogenesis and the Control of Microtubule Dynamics in Cells Journal of Cell Science. 1986: 293-310. PMID 3477556 DOI: 10.1242/Jcs.1986.Supplement_5.19  0.333
1986 McKeon FD, Kirschner MW, Caput D. Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature. 319: 463-8. PMID 3453101 DOI: 10.1038/319463A0  0.573
1986 Drubin DG, Kirschner MW. Tau protein function in living cells. The Journal of Cell Biology. 103: 2739-46. PMID 3098742 DOI: 10.1083/Jcb.103.6.2739  0.589
1986 Kristofferson D, Mitchison T, Kirschner M. Direct observation of steady-state microtubule dynamics. The Journal of Cell Biology. 102: 1007-19. PMID 3005332 DOI: 10.1083/Jcb.102.3.1007  0.615
1986 Drubin D, Kobayashi S, Kirschner M. Association of Tau Protein with Microtubules in Living Cells Annals of the New York Academy of Sciences. 466: 257-268. PMID 2873777 DOI: 10.1111/J.1749-6632.1986.Tb38398.X  0.348
1986 KRISTOFFERSON D, MITCHISON T, KIRSCHNER M. Direct Visualization of Steady State Microtubule Dynamics in Vitro Annals of the New York Academy of Sciences. 466: 664-665. DOI: 10.1111/J.1749-6632.1986.Tb38447.X  0.584
1985 Caron JM, Jones AL, Rall LB, Kirschner MW. Autoregulation of tubulin synthesis in enucleated cells Nature. 317: 648-651. PMID 4058574 DOI: 10.1038/317648A0  0.359
1985 Evans L, Mitchison T, Kirschner M. Influence of the centrosome on the structure of nucleated microtubules. The Journal of Cell Biology. 100: 1185-91. PMID 4038981 DOI: 10.1083/Jcb.100.4.1185  0.622
1985 Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation. The Journal of Cell Biology. 101: 766-77. PMID 4030894 DOI: 10.1083/Jcb.101.3.766  0.628
1985 Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. I. Microtubule nucleation and tubulin binding. The Journal of Cell Biology. 101: 755-65. PMID 4030893 DOI: 10.1083/Jcb.101.3.755  0.639
1985 Caron JM, Jones AL, Kirschner MW. Autoregulation of tubulin synthesis in hepatocytes and fibroblasts Journal of Cell Biology. 101: 1763-1772. PMID 3902854 DOI: 10.1083/Jcb.101.5.1763  0.308
1985 Miake-Lye R, Kirschner MW. Induction of early mitotic events in a cell-free system. Cell. 41: 165-75. PMID 3888406 DOI: 10.1016/0092-8674(85)90071-6  0.359
1985 Drubin DG, Feinstein SC, Shooter EM, Kirschner MW. Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors. The Journal of Cell Biology. 101: 1799-807. PMID 2997236 DOI: 10.1083/Jcb.101.5.1799  0.56
1985 Gard DL, Kirschner MW. A polymer-dependent increase in phosphorylation of beta-tubulin accompanies differentiation of a mouse neuroblastoma cell line. The Journal of Cell Biology. 100: 764-74. PMID 2857724 DOI: 10.1083/Jcb.100.3.764  0.341
1985 Kirschner M, Newport J, Gerhart J. The timing of early developmental events in Xenopus Trends in Genetics. 1: 41-47. DOI: 10.1016/0168-9525(85)90021-6  0.756
1984 Karsenti E, Kobayashi S, Mitchison T, Kirschner M. Role of the centrosome in organizing the interphase microtubule array: Properties of cytoplasts containing or lacking centrosomes Journal of Cell Biology. 98: 1763-1776. PMID 6725398 DOI: 10.1083/Jcb.98.5.1763  0.732
1984 Karsenti E, Newport J, Hubble R, Kirschner M. Interconversion of metaphase and interphase microtubule arrays, as studied by the injection of centrosomes and nuclei into Xenopus eggs. The Journal of Cell Biology. 98: 1730-45. PMID 6725396 DOI: 10.1083/Jcb.98.5.1730  0.728
1984 Lee G, Hynes R, Kirschner M. Temporal and spatial regulation of fibronectin in early Xenopus development Cell. 36: 729-740. PMID 6697394 DOI: 10.1016/0092-8674(84)90353-2  0.33
1984 Calarco-Gillam PD, Siebert MC, Hubble R, Mitchison T, Kirschner M. Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material. Cell. 35: 621-9. PMID 6652679 DOI: 10.1016/0092-8674(83)90094-6  0.645
1984 Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature. 312: 237-42. PMID 6504138 DOI: 10.1038/312237A0  0.612
1984 Mitchison T, Kirschner M. Microtubule assembly nucleated by isolated centrosomes. Nature. 312: 232-7. PMID 6504137 DOI: 10.1038/312232A0  0.642
1984 Gerhart J, Wu M, Kirschner M. Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs. The Journal of Cell Biology. 98: 1247-55. PMID 6425302 DOI: 10.1083/Jcb.98.4.1247  0.706
1984 Drubin DG, Caput D, Kirschner MW. Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes. The Journal of Cell Biology. 98: 1090-7. PMID 6421824 DOI: 10.1083/Jcb.98.3.1090  0.55
1984 McKeon FD, Tuffanelli DL, Kobayashi S, Kirschner MW. The redistribution of a conserved nuclear envelope protein during the cell cycle suggests a pathway for chromosome condensation. Cell. 36: 83-92. PMID 6420073 DOI: 10.1016/0092-8674(84)90076-X  0.601
1984 Newport JW, Kirschner MW. Regulation of the cell cycle during early Xenopus development. Cell. 37: 731-42. PMID 6378387 DOI: 10.1016/0092-8674(84)90409-4  0.642
1984 Karsenti E, Newport J, Kirschner M. Respective roles of centrosomes and chromatin in the conversion of microtubule arrays from interphase to metaphase. The Journal of Cell Biology. 99: 47s-54s. PMID 6235234 DOI: 10.1083/Jcb.99.1.47S  0.718
1984 Forbes DJ, Kirschner MW, Caput D, Dahlberg JE, Lund E. Differential expression of multiple U1 small nuclear RNAs in oocytes and embryos of Xenopus laevis. Cell. 38: 681-9. PMID 6207932 DOI: 10.1016/0092-8674(84)90263-0  0.506
1983 Hill TL, Kirschner MW. Regulation of microtubule and actin filament assembly-disassembly by associated small and large molecules International Review of Cytology. 185-234. PMID 6358104 DOI: 10.1016/S0074-7696(08)61018-9  0.353
1983 Miake-Lye R, Newport J, Kirschner M. Maturation-promoting factor induces nuclear envelope breakdown in cycloheximide-arrested embryos of Xenopus laevis. The Journal of Cell Biology. 97: 81-91. PMID 6345556 DOI: 10.1083/Jcb.97.1.81  0.647
1983 Forbes DJ, Kirschner MW, Newport JW. Spontaneous formation of nucleus-like structures around bacteriophage DNA microinjected into Xenopus eggs. Cell. 34: 13-23. PMID 6224569 DOI: 10.1016/0092-8674(83)90132-0  0.695
1983 McKeon FD, Tuffanelli DL, Fukuyama K, Kirschner MW. Autoimmune response directed against conserved determinants of nuclear envelope proteins in a patient with linear scleroderma. Proceedings of the National Academy of Sciences of the United States of America. 80: 4374-8. PMID 6192431 DOI: 10.1073/Pnas.80.14.4374  0.564
1983 Forbes DJ, Kornberg TB, Kirschner MW. Small nuclear RNA transcription and ribonucleoprotein assembly in early Xenopus development. The Journal of Cell Biology. 97: 62-72. PMID 6190822 DOI: 10.1083/Jcb.97.1.62  0.55
1982 Newport J, Kirschner M. A major developmental transition in early Xenopus embryos: II. Control of the onset of transcription. Cell. 30: 687-96. PMID 7139712 DOI: 10.1016/0092-8674(82)90273-2  0.62
1982 Ring D, Hubble R, Kirschner M. Mitosis in a cell with multiple centrioles. Journal of Cell Biology. 94: 549-556. PMID 7130271 DOI: 10.1083/Jcb.94.3.549  0.345
1982 Cleveland D, Kirschner M. Autoregulatory control of the expression of α- and β-tubulins: Implications for microtubule assembly Cold Spring Harbor Symposia On Quantitative Biology. 46: 171-183. PMID 6286212 DOI: 10.1101/Sqb.1982.046.01.020  0.503
1982 Newport J, Kirschner M. A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage. Cell. 30: 675-86. PMID 6183003 DOI: 10.1016/0092-8674(82)90272-0  0.637
1982 Hill TL, Kirschner MW. Bioenergetics and kinetics of microtubule and actin filament assembly-disassembly. International Review of Cytology-a Survey of Cell Biology. 78: 1-125. DOI: 10.1016/S0074-7696(08)60105-9  0.306
1981 Valenzuela P, Quiroga M, Zaldivar J, Rutter WJ, Kirschner MW, Cleveland DW. Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. Nature. 289: 650-5. PMID 7464932 DOI: 10.1038/289650A0  0.459
1981 Gerhart J, Ubbels G, Black S, Hara K, Kirschner M. A reinvestigation of the role of the grey crescent in axis formation in xenopus laevis. Nature. 292: 511-6. PMID 7195987 DOI: 10.1038/292511A0  0.673
1981 Cleveland DW, Hughes SH, Stubblefield E, Kirschner MW, Varmus HE. Multiple alpha and beta tubulin genes represent unlinked and dispersed gene families. The Journal of Biological Chemistry. 256: 3130-4. PMID 6259149  0.39
1981 Cleveland DW, Lopata MA, Sherline P, Kirschner MW. Unpolymerized tubulin modulates the level of tubulin mRNAs. Cell. 25: 537-46. PMID 6116546 DOI: 10.1016/0092-8674(81)90072-6  0.523
1981 Kirschner MW, Gerhart JC. Spatial and Temporal Changes in the Amphibian Egg Bioscience. 31: 381-388. DOI: 10.2307/1308403  0.341
1980 Hara K, Tydeman P, Kirschner M. A cytoplasmic clock with the same period as the division cycle in Xenopus eggs. Proceedings of the National Academy of Sciences of the United States of America. 77: 462-6. PMID 6928638 DOI: 10.1073/Pnas.77.1.462  0.312
1980 Kirschner MW. Implications of treadmilling for the stability and polarity of actin and tubulin polymers in vivo. The Journal of Cell Biology. 86: 330-4. PMID 6893454 DOI: 10.1083/Jcb.86.1.330  0.307
1980 Heuser JE, Kirschner MW. Filament organization revealed in platinum replicas of freeze-dried cytoskeletons. The Journal of Cell Biology. 86: 212-34. PMID 6893451 DOI: 10.1083/Jcb.86.1.212  0.332
1980 Cleveland DW, Lopata MA, MacDonald RJ, Cowan NJ, Rutter WJ, Kirschner MW. Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 20: 95-105. PMID 6893015 DOI: 10.1016/0092-8674(80)90238-X  0.471
1980 Sánchez F, Natzle JE, Cleveland DW, Kirschner MW, McCarthy BJ. A dispersed multigene family encoding tubulin in Drosophila melanogaster. Cell. 22: 845-54. PMID 6780200 DOI: 10.1016/0092-8674(80)90561-9  0.466
1980 Summers K, Kirschner MW. Characteristics of the polar assembly and disassembly of microtubules observed in vitro by darkfield light microscopy. The Journal of Cell Biology. 83: 205-17. PMID 511939 DOI: 10.1083/Jcb.83.1.205  0.317
1980 Kirschner MW. Microtubule assembly and nucleation. International Review of Cytology. 54: 1-71. PMID 391755 DOI: 10.1016/S0074-7696(08)60164-3  0.358
1980 Kirschner MW, Butner KA, Newport JW, Black SD, Scharf SR, Gerhart JC. Spatial and temporal changes in early amphibian development Netherlands Journal of Zoology. 31: 50-77. DOI: 10.1163/002829680X00195  0.778
1979 Spiegelman BM, Lopata MA, Kirschner MW. Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells. Cell. 16: 253-63. PMID 455435 DOI: 10.1016/0092-8674(79)90003-5  0.538
1979 Spiegelman BM, Lopata MA, Kirschner MW. Multiple sites for the initiation of microtubule assembly in mammalian cells. Cell. 16: 239-52. PMID 455434 DOI: 10.1016/0092-8674(79)90002-3  0.511
1979 Cleveland DW, Spiegelman BM, Kirschner MW. Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. The Journal of Biological Chemistry. 254: 12670-8. PMID 227904  0.579
1978 Cleveland DW, Kirschner MW, Cowan NJ. Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products. Cell. 15: 1021-31. PMID 728983 DOI: 10.1016/0092-8674(78)90286-6  0.493
1978 Heidemann SR, Kirschner MW. Induced formation of asters and cleavage furrows in oocytes of Xenopus laevis during in vitro maturation. The Journal of Experimental Zoology. 204: 431-44. PMID 660144 DOI: 10.1002/Jez.1402040314  0.338
1978 Connolly JA, Kalnins VI, Cleveland DW, Kirschner MW. Intracellular localization of the high molecular weight microtubule accessory protein by indirect immunofluorescence. The Journal of Cell Biology. 76: 781-6. PMID 344329 DOI: 10.1083/Jcb.76.3.781  0.541
1977 Cleveland DW, Hwo SY, Kirschner MW. Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. Journal of Molecular Biology. 116: 207-25. PMID 599557 DOI: 10.1016/0022-2836(77)90213-3  0.521
1977 Spiegelman BM, Penningroth SM, Kirschner MW. Turnover of tubulin and the N site GTP in Chinese hamster ovary cells. Cell. 12: 587-600. PMID 562716 DOI: 10.1016/0092-8674(77)90259-8  0.53
1977 Connolly JA, Kalnins VI, Cleveland DW, Kirschner MW. Immunoflourescent staining of cytoplasmic and spindle microtubules in mouse fibroblasts with antibody to tau protein. Proceedings of the National Academy of Sciences of the United States of America. 74: 2437-40. PMID 329285 DOI: 10.1073/Pnas.74.6.2437  0.523
1977 Cleveland DW, Fischer SG, Kirschner MW, Laemmli UK. Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. The Journal of Biological Chemistry. 252: 1102-6. PMID 320200  0.399
1977 Penningroth SM, Kirschner MW. Nucleotide binding and phosphorylation in microtubule assembly in vitro. Journal of Molecular Biology. 115: 643-73. PMID 201762 DOI: 10.1016/0022-2836(77)90108-5  0.324
1977 Cleveland DW, Hwo SY, Kirschner MW. Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. Journal of Molecular Biology. 116: 227-47. PMID 146092 DOI: 10.1016/0022-2836(77)90214-5  0.513
1976 Witman GB, Cleveland DW, Weingarten MD, Kirschner MW. Tubulin requires tau for growth onto microtubule initiating sites. Proceedings of the National Academy of Sciences of the United States of America. 73: 4070-4. PMID 1069293 DOI: 10.1073/Pnas.73.11.4070  0.516
1975 Kirschner MW, Williams RC. The mechanism of microtubule assembly in vitro. Journal of Supramolecular Structure. 2: 412-28. PMID 4474574 DOI: 10.1002/Jss.400020229  0.331
1975 Heidemann SR, Kirschner MW. Aster formation in eggs of Xenopus laevis. Induction by isolated basal bodies. The Journal of Cell Biology. 67: 105-17. PMID 1236852 DOI: 10.1083/Jcb.67.1.105  0.336
1975 Kirschner MW, Honig LS, Williams RC. Quantitative electron microscopy of microtubule assembly in vitro. Journal of Molecular Biology. 99: 263-76. PMID 1206704 DOI: 10.1016/S0022-2836(75)80144-6  0.342
1975 Weingarten MD, Lockwood AH, Hwo SY, Kirschner MW. A protein factor essential for microtubule assembly. Proceedings of the National Academy of Sciences of the United States of America. 72: 1858-62. PMID 1057175 DOI: 10.1073/Pnas.72.5.1858  0.34
1974 Springer MS, Kirschner MW, Schachman HK. A difference sedimentation equilibrium technique for measuring small changes in molecular weight. I. Theory and computer simulation. Biochemistry. 13: 3718-26. PMID 4850196 DOI: 10.1021/Bi00715A016  0.466
1974 Kirschner MW, Williams RC, Weingarten M, Gerhart JC. Microtubules from mammalian brain: some properties of their depolymerization products and a proposed mechanism of assembly and disassembly. Proceedings of the National Academy of Sciences of the United States of America. 71: 1159-63. PMID 4524627 DOI: 10.1073/Pnas.71.4.1159  0.665
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