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Kevan Michael Shokat - Publications

Affiliations: 
1994-1999 Chemistry and Molecular Biology Princeton University, Princeton, NJ 
 1999- Chemistry University of California, Berkeley, Berkeley, CA, United States 
 1999- Cellular and Molecular Pharmacology University of California, San Francisco, San Francisco, CA 
Area:
Chemical Biology, Kinases, Gtpases, drug discovery
Website:
http://chemistry.berkeley.edu/faculty/chem/shokat
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Year Citation  Score
2024 Leyte-Vidal A, DeFilippis R, Outhwaite IR, Kwan I, Lee JY, Leavitt C, Miller KB, Rea D, Rangwala AM, Lou K, Patel S, Alvarez A, Shokat KM, Bahar I, Seeliger MA, et al. Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib. Leukemia. PMID 39085402 DOI: 10.1038/s41375-024-02353-0  0.777
2024 Ostrem JML, Peters U, Shokat KM. Direct RAS inhibitors turn 10. Nature Chemical Biology. PMID 39060392 DOI: 10.1038/s41589-024-01691-5  0.711
2024 Zheng Q, Zhang Z, Guiley KZ, Shokat KM. Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D. Nature Chemical Biology. PMID 38443470 DOI: 10.1038/s41589-024-01565-w  0.453
2023 Malakoutikhah M, Mahran R, Gooran N, Masoumi A, Lundell K, Liljeblad A, Guiley K, Dai S, Zheng Q, Zhu L, Shokat KM, Kopra K, Härmä H. Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes. Analytical Chemistry. PMID 38060502 DOI: 10.1021/acs.analchem.3c02844  0.439
2023 Dugan M, Ferguson L, Hertz N, Chalkley R, Burlingame A, Shokat K, Parker P, Messing R. Chemical Genetic Identification of Protein Kinase C Epsilon Substrates in Mouse Brain. Molecular & Cellular Proteomics : McP. 100522. PMID 36863607 DOI: 10.1016/j.mcpro.2023.100522  0.727
2023 Ruiz-Saenz A, Atreya CE, Wang C, Pan B, Dreyer CA, Brunen D, Prahallad A, Muñoz DP, Ramms DJ, Burghi V, Spassov DS, Fewings E, Hwang YC, Cowdrey C, Moelders C, ... ... Shokat K, et al. A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF colorectal tumors. Nature Cancer. PMID 36759733 DOI: 10.1038/s43018-022-00508-5  0.664
2022 Lou K, Wassarman DR, Yang T, Paung Y, Zhang Z, O'Loughlin TA, Moore MK, Egan RK, Greninger P, Benes CH, Seeliger MA, Taunton J, Gilbert LA, Shokat KM. IFITM proteins assist cellular uptake of diverse linked chemotypes. Science (New York, N.Y.). 378: 1097-1104. PMID 36480603 DOI: 10.1126/science.abl5829  0.783
2022 Dai SA, Hu Q, Gao R, Blythe EE, Touhara KK, Peacock H, Zhang Z, von Zastrow M, Suga H, Shokat KM. State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides. Cell. PMID 36170854 DOI: 10.1016/j.cell.2022.09.019  0.557
2022 Zhang Z, Fan Q, Luo X, Lou K, Weiss WA, Shokat KM. Brain-restricted mTOR inhibition with binary pharmacology. Nature. 609: 822-828. PMID 36104566 DOI: 10.1038/s41586-022-05213-y  0.816
2022 Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, ... Shokat KM, et al. Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor. Science Translational Medicine. 14: eabj8670. PMID 36103516 DOI: 10.1126/scitranslmed.abj8670  0.755
2022 Wassarman DR, Bankapalli K, Pallanck LJ, Shokat KM. Tissue-restricted inhibition of mTOR using chemical genetics. Proceedings of the National Academy of Sciences of the United States of America. 119: e2204083119. PMID 36095197 DOI: 10.1073/pnas.2204083119  0.446
2022 Vasta JD, Peacock DM, Zheng Q, Walker JA, Zhang Z, Zimprich CA, Thomas MR, Beck MT, Binkowski BF, Corona CR, Robers MB, Shokat KM. KRAS is vulnerable to reversible switch-II pocket engagement in cells. Nature Chemical Biology. PMID 35314814 DOI: 10.1038/s41589-022-00985-w  0.538
2022 Werr L, Plenker D, Dammert MA, Lorenz C, Brägelmann J, Tumbrink HL, Klein S, Schmitt A, Büttner R, Persigehl T, Shokat KM, Wunderlich FT, Schram AM, Peifer M, Sos ML, et al. CD74-NRG1 fusions are oncogenic in vivo and induce therapeutically tractable ERBB2:ERBB3 heterodimerization. Molecular Cancer Therapeutics. PMID 35247925 DOI: 10.1158/1535-7163.MCT-21-0820  0.592
2022 Zheng Q, Peacock DM, Shokat KM. Drugging the Next Undruggable KRAS Allele-Gly12Asp. Journal of Medicinal Chemistry. PMID 35167298 DOI: 10.1021/acs.jmedchem.2c00099  0.443
2022 Melnyk JE, Steri V, Nguyen HG, Hwang YC, Gordan JD, Hann B, Feng FY, Shokat KM. Targeting a splicing-mediated drug resistance mechanism in prostate cancer by inhibiting transcriptional regulation by PKCβ1. Oncogene. PMID 35087237 DOI: 10.1038/s41388-022-02179-z  0.591
2021 Parker N, Laychur A, Sukwani M, Orwig KE, Oatley JM, Zhang C, Rutaganira FU, Shokat K, Wright WW. Spermatogonial Stem Cell Numbers Are Reduced by Transient Inhibition of GDNF Signaling but Restored by Self-Renewing Replication when Signaling Resumes. Stem Cell Reports. PMID 33636117 DOI: 10.1016/j.stemcr.2021.01.015  0.722
2021 Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GM, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, ... ... Shokat KM, et al. Drugging the 'undruggable' MYCN oncogenic transcription factor: Overcoming previous obstacles to impact childhood cancers. Cancer Research. PMID 33509943 DOI: 10.1158/0008-5472.CAN-20-3108  0.488
2020 Zhang Z, Gao R, Hu Q, Peacock H, Peacock DM, Dai S, Shokat KM, Suga H. GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf. Acs Central Science. 6: 1753-1761. PMID 33145412 DOI: 10.1021/acscentsci.0c00514  0.407
2020 Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, ... ... Shokat KM, et al. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. PMID 32645325 DOI: 10.1016/J.Cell.2020.06.034  0.435
2020 Coles GL, Cristea S, Webber JT, Levin RS, Moss SM, He A, Sangodkar J, Hwang YC, Arand J, Drainas AP, Mooney NA, Demeter J, Spradlin JN, Mauch B, Le V, ... ... Shokat KM, et al. Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells. Cancer Cell. PMID 32531271 DOI: 10.1016/J.Ccell.2020.05.003  0.835
2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, ... ... Shokat K, et al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. Biorxiv : the Preprint Server For Biology. PMID 32511329 DOI: 10.1101/2020.03.22.002386  0.789
2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, ... ... Shokat KM, et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. PMID 32353859 DOI: 10.1038/S41586-020-2286-9  0.798
2020 Tan X, Banerjee P, Pham EA, Rutaganira FUN, Basu K, Bota-Rabassedas N, Guo HF, Grzeskowiak CL, Liu X, Yu J, Shi L, Peng DH, Rodriguez BL, Zhang J, Zheng V, ... ... Shokat K, et al. PI4KIIIβ is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma. Science Translational Medicine. 12. PMID 31969487 DOI: 10.1126/Scitranslmed.Aax3772  0.747
2019 Guiley KZ, Stevenson JW, Lou K, Barkovich KJ, Kumarasamy V, Wijeratne TU, Bunch KL, Tripathi S, Knudsen ES, Witkiewicz AK, Shokat KM, Rubin SM. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science (New York, N.Y.). 366. PMID 31831640 DOI: 10.1126/Science.Aaw2106  0.845
2019 Wong RA, Luo X, Lu M, An Z, Haas-Kogan DA, Philips JJ, Shokat KM, Weiss WA, Fan QW. Cooperative blockade of PKCα and JAK2 drives apoptosis in glioblastoma. Cancer Research. PMID 31806641 DOI: 10.1158/0008-5472.Can-18-2808  0.634
2019 Fan Q, An Z, Wong RA, Luo X, Lu E, Baldwin A, Mayekar MK, Haderk F, Shokat KM, Bivona TG, Weiss WA. Betacellulin drives therapy-resistance in glioblastoma. Neuro-Oncology. PMID 31678994 DOI: 10.1093/Neuonc/Noz206  0.498
2019 Loonat AA, Martin ED, Sarafraz-Shekary N, Tilgner K, Hertz NT, Levin R, Shokat KM, Burlingame AL, Arabacilar P, Uddin S, Thomas M, Marber MS, Clark JE. p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701545R. PMID 31638431 DOI: 10.1096/Fj.201701545R  0.795
2019 Lou K, Gilbert LA, Shokat KM. A Bounty of New Challenging Targets in Oncology for Chemical Discovery. Biochemistry. PMID 31343870 DOI: 10.1021/Acs.Biochem.9B00570  0.746
2019 Lou K, Steri V, Ge AY, Hwang YC, Yogodzinski CH, Shkedi AR, Choi ALM, Mitchell DC, Swaney DL, Hann B, Gordan JD, Shokat KM, Gilbert LA. KRAS inhibition produces a driver-limited state revealing collateral dependencies. Science Signaling. 12. PMID 31138768 DOI: 10.1126/Scisignal.Aaw9450  0.827
2019 Hernández-Ortega S, Sánchez-Botet A, Quandt E, Masip N, Gasa L, Verde G, Jiménez J, Levin RS, Rutaganira FU, Burlingame AL, Wolfgeher D, Ribeiro MPC, Kron SJ, Shokat KM, Clotet J. Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex. Experimental & Molecular Medicine. 51: 44. PMID 30992425 DOI: 10.1038/S12276-019-0242-2  0.834
2019 Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, Mukherjee S. A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis. Cell Host & Microbe. PMID 30827827 DOI: 10.1016/J.Chom.2019.01.006  0.662
2019 Katsuno Y, Meyer DS, Zhang Z, Shokat KM, Akhurst RJ, Miyazono K, Derynck R. Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition. Science Signaling. 12. PMID 30808819 DOI: 10.1126/Scisignal.Aau8544  0.3
2019 Wong AW, Urisman A, Burlingame AL, Shokat KM. Chemically reprogramming the phospho-transfer reaction to crosslink protein kinases to their substrates. Protein Science : a Publication of the Protein Society. PMID 30636329 DOI: 10.1002/Pro.3570  0.802
2019 Wen Fan Q, Lorenzana E, Luo X, Lea R, Aksoy O, An Z, Ozawa T, Wassarman D, Shokat K, Aggen J, Smith JAM, Singh M, Butowski N, Raleigh D, Weiss W. DDIS-33. SELECTIVE AND COMPLETE INHIBITION OF mTORC1 BY BI-STERIC mTOR INHIBITORS DRIVES THERAPEUTIC RESPONSE IN GLIOBLASTOMA Neuro-Oncology. 21: vi70-vi70. DOI: 10.1093/Neuonc/Noz175.284  0.643
2019 Luo X, Fan Q, Shokat KM, Weiss WA. THER-08. RAPLINK-1 COOPERATES WITH INHIBITORS OF Bcl-2/Bcl-xl TO INDUCE APOPTOSIS IN GLIOBLASTOMA Neuro-Oncology. 21: ii115-ii115. DOI: 10.1093/Neuonc/Noz036.215  0.503
2018 Chamberlain CE, German MS, Yang K, Wang J, VanBrocklin H, Regan M, Shokat KM, Ducker GS, Kim GE, Hann B, Donner DB, Warren RS, Venook AP, Bergsland EK, Lee D, et al. A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-Resistant Tumors. Molecular Cancer Therapeutics. PMID 30254185 DOI: 10.1158/1535-7163.Mct-17-1204  0.692
2018 Ocasio CA, Warkentin AA, McIntyre PJ, Barkovich KJ, Vesely C, Spencer J, Shokat KM, Bayliss R. Type II kinase inhibitors targeting Cys-gatekeeper kinases display orthogonality with wild type and Ala/Gly-gatekeeper kinases. Acs Chemical Biology. PMID 30239186 DOI: 10.1021/Acschembio.8B00592  0.854
2018 Chorba JS, Galvan AM, Shokat KM. A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9. Journal of Visualized Experiments : Jove. PMID 30222160 DOI: 10.3791/58265  0.77
2018 Barkovich KJ, Moore MK, Hu Q, Shokat KM. Chemical genetic inhibition of DEAD-box proteins using covalent complementarity. Nucleic Acids Research. PMID 30102385 DOI: 10.1093/Nar/Gky706  0.813
2018 Donnella HJ, Webber JT, Levin RS, Camarda R, Momcilovic O, Bayani N, Shah KN, Korkola JE, Shokat KM, Goga A, Gordan JD, Bandyopadhyay S. Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer. Nature Chemical Biology. PMID 29942081 DOI: 10.1038/S41589-018-0081-9  0.811
2018 Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP. Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy. Plos One. 13: e0193849. PMID 29799846 DOI: 10.1371/Journal.Pone.0193849  0.745
2018 Chorba JS, Galvan AM, Shokat KM. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. The Journal of Biological Chemistry. 293: 6692. PMID 29728531 DOI: 10.1074/Jbc.Aac118.003335  0.776
2018 Hu Q, Shokat KM. Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP. Cell. PMID 29628140 DOI: 10.1016/J.Cell.2018.03.018  0.499
2018 Nnadi CI, Jenkins ML, Gentile DR, Bateman LA, Zaidman D, Balius TE, Nomura DK, Burke JE, Shokat KM, London N. Novel K-Ras G12C Switch-II covalent binders destabilize Ras and accelerate nucleotide exchange. Journal of Chemical Information and Modeling. PMID 29320178 DOI: 10.1021/Acs.Jcim.7B00399  0.802
2018 Donnella H, Webber J, Shokat K, Goga A, Gordan J, Bandyopadhyay S. Abstract A45: Kinome rewiring reveals AURKA is a molecular barrier to the efficacy of PI3K/mTOR-pathway inhibitors in breast cancer Molecular Cancer Research. 16. DOI: 10.1158/1557-3125.Advbc17-A45  0.683
2017 Chorba JS, Galvan AM, Shokat KM. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. The Journal of Biological Chemistry. PMID 29259136 DOI: 10.1074/jbc.RA117.000754  0.757
2017 Gentile DR, Rathinaswamy MK, Jenkins ML, Moss SM, Siempelkamp BD, Renslo AR, Burke JE, Shokat KM. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. Cell Chemical Biology. PMID 29033317 DOI: 10.1016/J.Chembiol.2017.08.025  0.786
2017 Rutaganira FU, Barks J, Dhason MS, Wang Q, Lopez MS, Long S, Radke JB, Jones NG, Maddirala AR, Janetka JW, El Bakkouri M, Hui R, Shokat KM, Sibley LD. Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii. Journal of Medicinal Chemistry. PMID 28933846 DOI: 10.1021/Acs.Jmedchem.7B01192  0.829
2017 Morisot N, Novotny CJ, Shokat KM, Ron D. A new generation of mTORC1 inhibitor attenuates alcohol intake and reward in mice. Addiction Biology. PMID 28681511 DOI: 10.1111/Adb.12528  0.769
2017 Dang CV, Reddy EP, Shokat KM, Soucek L. Drugging the 'undruggable' cancer targets. Nature Reviews. Cancer. PMID 28643779 DOI: 10.1038/Nrc.2017.36  0.316
2017 McGregor LM, Jenkins ML, Kerwin C, Burke JE, Shokat KM. Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes. Biochemistry. PMID 28621541 DOI: 10.1021/Acs.Biochem.7B00271  0.759
2017 Plenker D, Riedel M, Brägelmann J, Dammert MA, Chauhan R, Knowles PP, Lorenz C, Keul M, Bührmann M, Pagel O, Tischler V, Scheel AH, Schütte D, Song Y, Stark J, ... ... Shokat KM, et al. Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors. Science Translational Medicine. 9. PMID 28615362 DOI: 10.1126/Scitranslmed.Aah6144  0.71
2017 Hoppmann C, Wong A, Yang B, Li S, Hunter T, Shokat KM, Wang L. Site-specific incorporation of phosphotyrosine using an expanded genetic code. Nature Chemical Biology. PMID 28604697 DOI: 10.1038/Nchembio.2406  0.782
2017 Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. The Journal of Clinical Investigation. 127: 2438. PMID 28569734 DOI: 10.1172/JCI95182  0.648
2017 Novotny CJ, Hamilton GL, McCormick F, Shokat K. Farnesyltransferase-mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras. Acs Chemical Biology. PMID 28530791 DOI: 10.1021/Acschembio.7B00374  0.786
2017 Liu KH, Niu Y, Konishi M, Wu Y, Du H, Sun Chung H, Li L, Boudsocq M, McCormack M, Maekawa S, Ishida T, Zhang C, Shokat K, Yanagisawa S, Sheen J. Discovery of nitrate-CPK-NLP signalling in central nutrient-growth networks. Nature. PMID 28489820 DOI: 10.1038/Nature22077  0.385
2017 Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat KM, Nakamura K. Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease. Neurochemistry International. PMID 28434973 DOI: 10.1016/J.Neuint.2017.04.006  0.785
2017 Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA. A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. Cancer Cell. 31: 424-435. PMID 28292440 DOI: 10.1016/J.Ccell.2017.01.014  0.851
2017 Reed DE, Shokat KM. INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC. Molecular Cancer Research : McR. PMID 28196852 DOI: 10.1158/1541-7786.Mcr-16-0183  0.819
2017 Uchida Y, Rutaganira FU, Jullié D, Shokat KM, von Zastrow M. Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling. Molecular Pharmacology. 91: 65-73. PMID 27821547 DOI: 10.1124/Mol.116.106252  0.77
2017 Lazarus MB, Levin RS, Shokat KM. Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response. Cellular Signalling. 29: 78-83. PMID 27760376 DOI: 10.1016/J.Cellsig.2016.10.006  0.824
2017 Shokat KM. Abstract IA25: Third-generation inhibitors of mTOR Cancer Research. 77. DOI: 10.1158/1538-7445.Transcontrol16-Ia25  0.46
2017 Aksoy O, Fan Q, Shokat K, Ruggero D, Weiss W. CSIG-42. UNDERSTANDING THE ROLE OF TRANSLATIONAL CONTROL IN MYCN-DRIVEN MEDULLOBLASTOMA Neuro-Oncology. 19: vi58-vi58. DOI: 10.1093/Neuonc/Nox168.236  0.453
2016 Urisman A, Levin RS, Gordan JD, Webber JT, Hernandez H, Ishihama Y, Shokat KM, Burlingame AL. An optimized chromatographic strategy for multiplexing in parallel reaction monitoring mass spectrometry: Insights from quantitation of activated kinases. Molecular & Cellular Proteomics : McP. PMID 27940637 DOI: 10.1074/Mcp.M116.058172  0.837
2016 Novotny CJ, Pollari S, Park JH, Lemmon MA, Shen W, Shokat KM. Overcoming resistance to HER2 inhibitors through state-specific kinase binding. Nature Chemical Biology. 12: 923-930. PMID 27595329 DOI: 10.1038/Nchembio.2171  0.651
2016 Levin RS, Hertz NT, Burlingame AL, Shokat KM, Mukherjee S. Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen. Proceedings of the National Academy of Sciences of the United States of America. 113: E4776-83. PMID 27482120 DOI: 10.1073/Pnas.1608355113  0.836
2016 Ostrem JM, Shokat KM. Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design. Nature Reviews. Drug Discovery. 15: 771-785. PMID 27469033 DOI: 10.1038/Nrd.2016.139  0.787
2016 Miller RE, Brough R, Bajrami I, Williamson CT, McDade S, Campbell J, Kigozi A, Rafiq R, Pemberton H, Natrajan R, Joel J, Astley H, Mahoney C, Moore JD, Torrance C, ... ... Shokat KM, et al. Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib. Molecular Cancer Therapeutics. 15: 1472-84. PMID 27364904 DOI: 10.1158/1535-7163.Mct-15-0554  0.816
2016 Rodrik-Outmezguine VS, Okaniwa M, Yao Z, Novotny CJ, McWhirter C, Banaji A, Won H, Wong W, Berger M, de Stanchina E, Barratt DG, Cosulich S, Klinowska T, Rosen N, Shokat KM. Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor. Nature. 534: 272-6. PMID 27279227 DOI: 10.1038/Nature17963  0.83
2016 Saha SK, Gordan JD, Kleinstiver BP, Vu P, Najem MS, Yeo JC, Shi L, Kato Y, Levin RS, Webber JT, Damon LJ, Egan RK, Greninger P, McDermott U, Garnett MJ, ... ... Shokat KM, et al. Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. Cancer Discovery. 6: 727-39. PMID 27231123 DOI: 10.1158/2159-8290.Cd-15-1442  0.835
2016 Tabaei SR, Guo F, Rutaganira FU, Vafaei S, Choong I, Shokat KM, Glenn JS, Cho NJ. Multistep Compositional Remodeling of Supported Lipid Membranes by Interfacially Active Phosphatidylinositol Kinases. Analytical Chemistry. 88: 5042-5. PMID 27118725 DOI: 10.1021/Acs.Analchem.6B01293  0.783
2016 Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, et al. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 29: 536-47. PMID 27050099 DOI: 10.1016/J.Ccell.2016.03.001  0.714
2016 Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. Cell Chemical Biology: Home of Exciting Chemical Biology. Cell Chemical Biology. 23: 1-2. PMID 26933730 DOI: 10.1016/J.Chembiol.2016.01.001  0.365
2016 Rutaganira FU, Fowler ML, McPhail JA, Gelman MA, Nguyen K, Xiong A, Dornan GL, Tavshanjian B, Glenn JS, Shokat KM, Burke JE. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. Journal of Medicinal Chemistry. 59: 1830-9. PMID 26885694 DOI: 10.1021/Acs.Jmedchem.5B01311  0.822
2016 Fowler ML, McPhail JA, Jenkins ML, Masson GR, Rutaganira FU, Shokat KM, Williams RL, Burke JE. Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11. Protein Science : a Publication of the Protein Society. 25: 826-39. PMID 26756197 DOI: 10.1002/Pro.2879  0.752
2016 Sansó M, Levin RS, Lipp JJ, Wang VY, Greifenberg AK, Quezada EM, Ali A, Ghosh A, Larochelle S, Rana TM, Geyer M, Tong L, Shokat KM, Fisher RP. P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates. Genes & Development. 30: 117-31. PMID 26728557 DOI: 10.1101/Gad.269589.115  0.809
2016 Floor SN, Barkovich KJ, Condon KJ, Shokat KM, Doudna JA. Analog sensitive chemical inhibition of the DEAD-box protein DDX3. Protein Science : a Publication of the Protein Society. 25: 638-49. PMID 26650549 DOI: 10.1002/Pro.2857  0.809
2016 Samson S, Zhou AY, Martins M, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan J, Levin R, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemens P, ... ... Shokat K, et al. Abstract C88: Genomics, advocacy, and emerging therapeutics to address triple-negative breast cancer (TNBC) outcome disparities. Cancer Epidemiology, Biomarkers & Prevention. 25. DOI: 10.1158/1538-7755.Disp15-C88  0.778
2016 Novotny CJ, Pollari S, Park JH, Lemmon MA, Schultz PG, Shen W, Shokat KM. Abstract 3904: Overcoming resistance to HER2 inhibitors through cell based screening Cancer Research. 76: 3904-3904. DOI: 10.1158/1538-7445.Am2016-3904  0.677
2016 Rodrik-Outmezguine VS, Okaniwa M, Yao Z, Novotny C, McWhirter C, Banaji A, Won H, Wong W, Berger M, Stanchina Ed, Barratt DG, Cosulich S, Klinowska T, Rosen N, Shokat KM. Abstract 2147: Overcoming mTOR resistance mutations with a new generation mTOR inhibitor Cancer Research. 76: 2147-2147. DOI: 10.1158/1538-7445.Am2016-2147  0.809
2015 Kuhlenschmidt TB, Rutaganira FU, Long S, Tang K, Shokat KM, Kuhlenschmidt MS, Sibley LD. Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1) In Vitro by Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture. Antimicrobial Agents and Chemotherapy. 60: 570-9. PMID 26552986 DOI: 10.1128/Aac.01915-15  0.785
2015 Costa HA, Leitner MG, Sos ML, Mavrantoni A, Rychkova A, Johnson JR, Newton BW, Yee MC, De La Vega FM, Ford JM, Krogan NJ, Shokat KM, Oliver D, Halaszovich CR, Bustamante CD. Discovery and functional characterization of a neomorphic PTEN mutation. Proceedings of the National Academy of Sciences of the United States of America. 112: 13976-81. PMID 26504226 DOI: 10.1073/Pnas.1422504112  0.696
2015 Schaffer BE, Levin RS, Hertz NT, Maures TJ, Schoof ML, Hollstein PE, Benayoun BA, Banko MR, Shaw RJ, Shokat KM, Brunet A. Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction. Cell Metabolism. 22: 907-21. PMID 26456332 DOI: 10.1016/J.Cmet.2015.09.009  0.826
2015 Manz BN, Tan YX, Courtney AH, Rutaganira F, Palmer E, Shokat KM, Weiss A. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. 4. PMID 26302204 DOI: 10.7554/Elife.08088  0.78
2015 Lazarus MB, Shokat KM. Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1. Bioorganic & Medicinal Chemistry. 23: 5483-8. PMID 26275681 DOI: 10.1016/J.Bmc.2015.07.034  0.676
2015 Lipp JJ, Marvin MC, Shokat KM, Guthrie C. SR protein kinases promote splicing of nonconsensus introns. Nature Structural & Molecular Biology. 22: 611-7. PMID 26167880 DOI: 10.1038/Nsmb.3057  0.827
2015 Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I. WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science Signaling. 8: ra65. PMID 26126716 DOI: 10.1126/Scisignal.Aaa0354  0.727
2015 Cage TA, Chanthery Y, Chesler L, Grimmer M, Knight Z, Shokat K, Weiss WA, Gustafson WC. Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer. Frontiers in Oncology. 5: 111. PMID 26029667 DOI: 10.3389/Fonc.2015.00111  0.773
2015 Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife. 4. PMID 25986605 DOI: 10.7554/Elife.05434  0.843
2015 Martin H, Shales M, Fernandez-Piñar P, Wei P, Molina M, Fiedler D, Shokat KM, Beltrao P, Lim W, Krogan NJ. Differential genetic interactions of yeast stress response MAPK pathways. Molecular Systems Biology. 11: 800. PMID 25888283 DOI: 10.15252/Msb.20145606  0.564
2015 Bailey FP, Byrne DP, Oruganty K, Eyers CE, Novotny CJ, Shokat KM, Kannan N, Eyers PA. The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner. The Biochemical Journal. 467: 47-62. PMID 25583260 DOI: 10.1042/Bj20141441  0.842
2015 Lazarus MB, Novotny CJ, Shokat KM. Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors. Acs Chemical Biology. 10: 257-61. PMID 25551253 DOI: 10.1021/Cb500835Z  0.832
2015 Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Molecular Cancer Therapeutics. 14: 419-28. PMID 25522764 DOI: 10.1158/1535-7163.Mct-14-0526  0.694
2015 Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, ... ... Shokat KM, et al. Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discovery. 5: 154-67. PMID 25501949 DOI: 10.1158/2159-8290.Cd-14-0552  0.788
2015 Manz BN, Tan YX, Courtney AH, Rutaganira F, Palmer E, Shokat KM, Weiss A. Author response: Small molecule inhibition of Csk alters affinity recognition by T cells Elife. DOI: 10.7554/Elife.08088.012  0.729
2015 Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Author response: Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic Elife. DOI: 10.7554/Elife.05434.022  0.73
2015 Cage TA, Chanthery Y, Chesler L, Grimmer M, Knight Z, Shokat K, Weiss WA, Gustafson WC. Downregulation of MYCN through PI3K inhibition in mouse models of pediatric neural cancer Frontiers in Oncology. 5. DOI: 10.3389/fonc.2015.00111  0.668
2015 Martin H, Shales M, Fernandez-Piñar P, Wei P, Molina M, Fiedler D, Shokat KM, Beltrao P, Lim W, Krogan NJ. Differential genetic interactions of yeast stress response MAPK pathways Molecular Systems Biology. 11: 1-13. DOI: 10.15252/msb.20145606  0.498
2015 Zhou AY, Martins MM, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, ... ... Shokat KM, et al. Abstract B48: Identification of novel drug interactions with MYC via a quantitative chemical-genetic interaction map Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-B48  0.346
2015 Reed DE, Shokat KM. Abstract PR01: Inhibitory role of phosphatidylinositol-3,4-bisphosphate in triple-negative breast cancers Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-Pr01  0.436
2015 Zhou AY, Martins MM, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, ... ... Shokat KM, et al. Abstract B44: A systems approach combining genomics, advocacy, and emerging novel therapeutics to address triple-negative breast cancer (TNBC) outcomes disparities Cancer Epidemiology, Biomarkers & Prevention. 24. DOI: 10.1158/1538-7755.Disp14-B44  0.33
2015 Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, ... ... Shokat KM, et al. Abstract PR15: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-Pr15  0.358
2015 Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, ... ... Shokat KM, et al. Abstract PR07: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-Pr07  0.356
2015 Ramkumar P, Levin RS, Sansó M, Jatiani S, Dar AC, Fisher RP, Shokat KM, Reddy EP. Abstract 2450: Identifying novel substrates of PLK2 using a chemical genetics approach Cancer Research. 75: 2450-2450. DOI: 10.1158/1538-7445.Am2015-2450  0.785
2015 Fan Q, Wong R, Novotny C, Okaniwa M, Nicolaides T, Shokat K, Weiss W. ATPS-94THIRD GENERATION mTOR INHIBITORS IN GLIOBLASTOMA Neuro-Oncology. 17: v39.2-v39. DOI: 10.1093/Neuonc/Nov204.94  0.848
2015 Li JJ, Cao C, Fixsen SM, Young JM, Ono C, Bando H, Elde NC, Katsuma S, Dever TE, Sicheri F, Shokat KM. Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe Proceedings of the National Academy of Sciences of the United States of America. 112: E4364-E4373. DOI: 10.1073/pnas.1505481112  0.62
2015 Lazarus MB, Novotny CJ, Shokat KM. Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors Acs Chemical Biology. 10: 257-261. DOI: 10.1021/cb500835z  0.642
2014 Warkentin AA, Lopez MS, Lasater EA, Lin K, He BL, Leung AY, Smith CC, Shah NP, Shokat KM. Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy. Elife. 3. PMID 25531068 DOI: 10.7554/Elife.03445  0.804
2014 Reed DE, Shokat KM. Targeting osteosarcoma. Proceedings of the National Academy of Sciences of the United States of America. 111: 18100-1. PMID 25512494 DOI: 10.1073/Pnas.1420596111  0.824
2014 Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN. MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. Neuron. 84: 968-82. PMID 25456499 DOI: 10.1016/J.Neuron.2014.10.025  0.769
2014 Shokat KM. Methods in Enzymology. Protein kinase inhibitors in research and medicine. Preface. Methods in Enzymology. 548: xi-xii. PMID 25399648 DOI: 10.1016/B978-0-12-397918-6.09986-9  0.455
2014 Lopez MS, Kliegman JI, Shokat KM. The logic and design of analog-sensitive kinases and their small molecule inhibitors. Methods in Enzymology. 548: 189-213. PMID 25399647 DOI: 10.1016/B978-0-12-397918-6.00008-2  0.856
2014 Chorba JS, Shokat KM. The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis. The Journal of Biological Chemistry. 289: 29030-43. PMID 25210046 DOI: 10.1074/Jbc.M114.594861  0.791
2014 Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell. 26: 414-27. PMID 25175806 DOI: 10.1016/J.Ccr.2014.07.015  0.846
2014 Mantilla CB, Stowe JM, Sieck DC, Ermilov LG, Greising SM, Zhang C, Shokat KM, Sieck GC. TrkB kinase activity maintains synaptic function and structural integrity at adult neuromuscular junctions. Journal of Applied Physiology (Bethesda, Md. : 1985). 117: 910-20. PMID 25170066 DOI: 10.1152/Japplphysiol.01386.2013  0.47
2014 Parker N, Falk H, Singh D, Fidaleo A, Smith B, Lopez MS, Shokat KM, Wright WW. Responses to glial cell line-derived neurotrophic factor change in mice as spermatogonial stem cells form progenitor spermatogonia which replicate and give rise to more differentiated progeny. Biology of Reproduction. 91: 92. PMID 25165119 DOI: 10.1095/Biolreprod.114.119099  0.62
2014 Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat KM, Ibanez CF. Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Elife. 3: e03245. PMID 25161195 DOI: 10.7554/Elife.03245  0.322
2014 Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. 111: E3679-88. PMID 25136127 DOI: 10.1073/Pnas.1413726111  0.354
2014 Sos ML, Levin RS, Gordan JD, Oses-Prieto JA, Webber JT, Salt M, Hann B, Burlingame AL, McCormick F, Bandyopadhyay S, Shokat KM. Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors. Cell Reports. 8: 1037-48. PMID 25127139 DOI: 10.1016/J.Celrep.2014.07.010  0.818
2014 Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, ... ... Shokat KM, et al. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proceedings of the National Academy of Sciences of the United States of America. 111: 9983-8. PMID 24961373 DOI: 10.1073/Pnas.1314939111  0.764
2014 Burke JE, Inglis AJ, Perisic O, Masson GR, McLaughlin SH, Rutaganira F, Shokat KM, Williams RL. Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors. Science (New York, N.Y.). 344: 1035-8. PMID 24876499 DOI: 10.1126/Science.1253397  0.772
2014 Riel-Mehan MM, Shokat KM. A crosslinker based on a tethered electrophile for mapping kinase-substrate networks. Chemistry & Biology. 21: 585-90. PMID 24746561 DOI: 10.1016/J.Chembiol.2014.02.022  0.838
2014 Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nature Immunology. 15: 186-94. PMID 24317039 DOI: 10.1038/Ni.2772  0.521
2014 Davies JM, Robinson AE, Cowdrey C, Mummaneni PV, Ducker GS, Shokat KM, Bollen A, Hann B, Phillips JJ. Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. Journal of Neurosurgery. 120: 331-6. PMID 24286145 DOI: 10.3171/2013.10.Jns13598  0.665
2014 Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat KM, Warren RS. Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors. Oncogene. 33: 1590-600. PMID 23542178 DOI: 10.1038/Onc.2013.92  0.814
2014 Warkentin AA, Lopez MS, Lasater EA, Lin K, He B, Leung AY, Smith CC, Shah NP, Shokat KM. Author response: Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy Elife. DOI: 10.7554/Elife.03445.010  0.737
2014 Gustafson WC, Meyerowitz JG, Nekritz EA, Charron E, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA. Abstract PR08: Drugging MYCN protein stability through an allosteric transition in Aurora kinase A Cancer Research. 74. DOI: 10.1158/1538-7445.Pedcan-Pr08  0.855
2014 Meyerowitz JG, Gustafson WC, Nekritz E, Swartling F, Shokat KM, Ruggero D, Weiss WA. Abstract B78: Targeting the translational apparatus in MYCN-driven medulloblastoma Cancer Research. 74. DOI: 10.1158/1538-7445.Pedcan-B78  0.797
2014 Sos ML, Levin R, Gordan J, Oses-Prieto J, Webber J, Salt M, Hann B, Burlingame A, Mccormick F, Bandyopadhyay S, Shokat K. Abstract LB-216: Integrated analysis of differential pathway resiliency in response to MAPK inhibition in BRAF-mutant cancer Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-216  0.818
2014 Maas NL, Levin R, Singh N, Shokat K, Diehl JA. Abstract 486: Uncovering novel PERK signaling pathways through chemical-genetic screening Cancer Research. 74: 486-486. DOI: 10.1158/1538-7445.Am2014-486  0.748
2014 Gustafson WC, Meyerowitz JG, Nekritz EA, Charron EA, Chanthery Y, Simonds E, Matthay K, Hertz N, Shokat K, Weiss WA. Abstract 2688: Drugging MYCN through an allosteric transition in Aurora A kinase Cancer Research. 74: 2688-2688. DOI: 10.1158/1538-7445.Am2014-2688  0.85
2014 Loonat A, Hunt F, Choi SH, Martin ED, Hertz NT, Levin B, Shokat KM, Burlingame AL, Marber MS, Clark JE. ELUCIDATING THE ROLE OF P38γ IN PATHOLOGICAL CARDIAC HYPERTROPHY Heart. 100: A18.2-A18. DOI: 10.1136/heartjnl-2014-306916.54  0.652
2014 Weiss W, Fan Q, Baldwin A, Wong R, Shokat K. ET-63 * TARGETING THE EGFR-STAT-NF- B AXIS IN GLIOBLASTOMA Neuro-Oncology. 16: v93-v93. DOI: 10.1093/Neuonc/Nou255.60  0.542
2014 Weiss WA, Wong R, Fan Q, Ilkhanizadeh S, Lu M, Beyer J, Dube N, Forsayeth J, Kells A, Xu T, Bankiewicz K, Ducker G, Feldman M, Shokat K. MTOR KINASE INHIBITORS AND APOPTOSIS IN GLIOBLASTOMA Neuro-Oncology. 16: iii31-iii31. DOI: 10.1093/Neuonc/Nou208.31  0.675
2014 Reed DE, Shokat KM. Targeting osteosarcoma Proceedings of the National Academy of Sciences of the United States of America. 111: 18100-18101. DOI: 10.1073/pnas.1420596111  0.776
2014 Sos M, Levin R, Gordan J, Oses-Prieto J, Webber J, Salt M, Hann B, Burlingame A, McCormick F, Bandyopadhyay S, Shokat K. 73 Differential pathway resiliency in response to MAPK inhibition in BRAF-mutant cancer European Journal of Cancer. 50: 28-29. DOI: 10.1016/S0959-8049(14)70199-6  0.799
2013 Kliegman JI, Fiedler D, Ryan CJ, Xu YF, Su XY, Thomas D, Caccese MC, Cheng A, Shales M, Rabinowitz JD, Krogan NJ, Shokat KM. Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae. Cell Reports. 5: 1725-36. PMID 24360963 DOI: 10.1016/J.Celrep.2013.11.040  0.831
2013 Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, et al. PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. Science Signaling. 6: ra105. PMID 24300897 DOI: 10.1126/Scisignal.2004125  0.821
2013 Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 503: 548-51. PMID 24256730 DOI: 10.1038/Nature12796  0.795
2013 Lopez MS, Choy JW, Peters U, Sos ML, Morgan DO, Shokat KM. Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. Journal of the American Chemical Society. 135: 18153-9. PMID 24171479 DOI: 10.1021/Ja408704U  0.861
2013 Atreya CE, Sangale Z, Xu N, Matli MR, Tikishvili E, Welbourn W, Stone S, Shokat KM, Warren RS. PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival. Cancer Medicine. 2: 496-506. PMID 24156022 DOI: 10.1002/Cam4.97  0.605
2013 Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA. EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. 24: 438-49. PMID 24135280 DOI: 10.1016/J.Ccr.2013.09.004  0.591
2013 Hertz NT, Berthet A, Sos ML, Thorn KS, Burlingame AL, Nakamura K, Shokat KM. A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell. 154: 737-47. PMID 23953109 DOI: 10.1016/J.Cell.2013.07.030  0.815
2013 Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM. Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. Acs Chemical Biology. 8: 1931-8. PMID 23841803 DOI: 10.1021/Cb400376P  0.848
2013 Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proceedings of the National Academy of Sciences of the United States of America. 110: 11988-93. PMID 23803853 DOI: 10.1073/Pnas.1310230110  0.748
2013 Schachter MM, Merrick KA, Larochelle S, Hirschi A, Zhang C, Shokat KM, Rubin SM, Fisher RP. A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression. Molecular Cell. 50: 250-60. PMID 23622515 DOI: 10.1016/J.Molcel.2013.04.003  0.501
2013 Lourido S, Zhang C, Lopez MS, Tang K, Barks J, Wang Q, Wildman SA, Shokat KM, Sibley LD. Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. Journal of Medicinal Chemistry. 56: 3068-77. PMID 23470217 DOI: 10.1021/Jm4001314  0.699
2013 Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptáček LJ, Fu YH. Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metabolism. 17: 291-302. PMID 23395175 DOI: 10.1016/J.Cmet.2012.12.017  0.597
2013 Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D. Abstract A46: Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-A46  0.763
2013 Shokat KM. Abstract SY19-01: Chemical genetic investigations of protein and lipid kinase signaling. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Sy19-01  0.413
2013 Ostrem JM, Peters U, Ren P, Liu Y, Wells JA, Shokat KM. Abstract LB-311: Development of mutant-specific small molecule inhibitors of K-Ras. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-311  0.803
2013 Amin DN, Ahuja D, Ducker GS, Yaswen P, Shokat K, Moasser M. Abstract 3043: Akt-mTorc2 signaling underlies cellular addiction to HER3 signaling in HER2-amplified cancers. Cancer Research. 73: 3043-3043. DOI: 10.1158/1538-7445.Am2013-3043  0.716
2013 Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. Abstract PL04-03: Selective inhibition of K-Ras G12C through allosteric control of GTP affinity and effector interactions. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-Pl04-03  0.798
2013 Sos ML, Gordan JD, Shokat KM. Abstract PR15: Primary resistance to MAPK inhibition in BRAF-mutant cancer is determined by kinetics of feedback release Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-Pr15  0.469
2013 Agarwal M, Nitta R, Dovat S, Li G, Arita H, Narita Y, Fukushima S, Tateishi K, Matsushita Y, Yoshida A, Miyakita Y, Ohno M, Collins VP, Kawahara N, Shibui S, ... ... Shokat K, et al. CELL BIOLOGY AND SIGNALING Neuro-Oncology. 15: iii12-iii31. DOI: 10.1093/Neuonc/Not174  0.486
2012 Ducker GS, Atreya CE, Simko J, Nakakura EK, Bergsland EK, Donner DB, Shokat KM, Warren RS. Effect of PIK3CA and KRAS mutations on sensitivity to ATP-competitive mTOR inhibitors in a primary xenograft model of colorectal carcinoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 483. PMID 27982970 DOI: 10.1200/Jco.2012.30.4_Suppl.483  0.802
2012 Soskis MJ, Ho HY, Bloodgood BL, Robichaux MA, Malik AN, Ataman B, Rubin AA, Zieg J, Zhang C, Shokat KM, Sharma N, Cowan CW, Greenberg ME. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nature Neuroscience. 15: 1645-54. PMID 23143520 DOI: 10.1038/Nn.3249  0.519
2012 Larochelle S, Amat R, Glover-Cutter K, Sansó M, Zhang C, Allen JJ, Shokat KM, Bentley DL, Fisher RP. Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II. Nature Structural & Molecular Biology. 19: 1108-15. PMID 23064645 DOI: 10.1038/Nsmb.2399  0.648
2012 Wohlbold L, Merrick KA, De S, Amat R, Kim JH, Larochelle S, Allen JJ, Zhang C, Shokat KM, Petrini JH, Fisher RP. Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. Plos Genetics. 8: e1002935. PMID 22927831 DOI: 10.1371/Journal.Pgen.1002935  0.688
2012 Simon MD, Shokat KM. A method to site-specifically incorporate methyl-lysine analogues into recombinant proteins. Methods in Enzymology. 512: 57-69. PMID 22910202 DOI: 10.1016/B978-0-12-391940-3.00003-2  0.558
2012 Sansó M, Lee KM, Viladevall L, Jacques PÉ, Pagé V, Nagy S, Racine A, St Amour CV, Zhang C, Shokat KM, Schwer B, Robert F, Fisher RP, Tanny JC. A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. Plos Genetics. 8: e1002822. PMID 22876190 DOI: 10.1371/Journal.Pgen.1002822  0.632
2012 Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proceedings of the National Academy of Sciences of the United States of America. 109: 12722-7. PMID 22802621 DOI: 10.1073/Pnas.1202492109  0.849
2012 Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D. Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing. The Journal of Clinical Investigation. 122: 2916-27. PMID 22772469 DOI: 10.1172/Jci60387  0.715
2012 Cibrián Uhalte E, Kirchner M, Hellwig N, Allen JJ, Donat S, Shokat KM, Selbach M, Abdelilah-Seyfried S. In vivo conditions to identify Prkci phosphorylation targets using the analog-sensitive kinase method in zebrafish. Plos One. 7: e40000. PMID 22768194 DOI: 10.1371/Journal.Pone.0040000  0.71
2012 Young ET, Zhang C, Shokat KM, Parua PK, Braun KA. The AMP-activated protein kinase Snf1 regulates transcription factor binding, RNA polymerase II activity, and mRNA stability of glucose-repressed genes in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 287: 29021-34. PMID 22761425 DOI: 10.1074/Jbc.M112.380147  0.409
2012 Jang M, Kim Y, Won H, Lim S, K R J, Dashdorj A, Min YH, Kim SY, Shokat KM, Ha J, Kim SS. Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Research. 72: 4214-24. PMID 22719067 DOI: 10.1158/0008-5472.Can-12-1110  0.335
2012 Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, ... ... Shokat KM, et al. Hierarchical modularity and the evolution of genetic interactomes across species. Molecular Cell. 46: 691-704. PMID 22681890 DOI: 10.1016/J.Molcel.2012.05.028  0.779
2012 Dar AC, Das TK, Shokat KM, Cagan RL. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 486: 80-4. PMID 22678283 DOI: 10.1038/Nature11127  0.767
2012 Barkovich KJ, Hariono S, Garske AL, Zhang J, Blair JA, Fan QW, Shokat KM, Nicolaides T, Weiss WA. Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers. Cancer Discovery. 2: 450-7. PMID 22588882 DOI: 10.1158/2159-8290.Cd-11-0287  0.816
2012 Sun Y, Miao Y, Yamane Y, Zhang C, Shokat KM, Takematsu H, Kozutsumi Y, Drubin DG. Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. Molecular Biology of the Cell. 23: 2388-98. PMID 22535525 DOI: 10.1091/Mbc.E12-03-0209  0.45
2012 St Amour CV, Sansó M, Bösken CA, Lee KM, Larochelle S, Zhang C, Shokat KM, Geyer M, Fisher RP. Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition. Molecular and Cellular Biology. 32: 2372-83. PMID 22508988 DOI: 10.1128/Mcb.06657-11  0.456
2012 Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ, Shokat KM, Fisher RP, Goga A. Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways. Proceedings of the National Academy of Sciences of the United States of America. 109: E1019-27. PMID 22474407 DOI: 10.1073/Pnas.1111317109  0.554
2012 Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Neuron. 73: 1127-42. PMID 22445341 DOI: 10.1016/J.Neuron.2012.01.019  0.752
2012 Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, ... ... Shokat KM, et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 485: 55-61. PMID 22367541 DOI: 10.1038/Nature10912  0.68
2012 Atreya CE, Ducker GS, Feldman ME, Bergsland EK, Warren RS, Shokat KM. Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer. Investigational New Drugs. 30: 2219-25. PMID 22270257 DOI: 10.1007/S10637-012-9793-Y  0.81
2012 Hengeveld RC, Hertz NT, Vromans MJ, Zhang C, Burlingame AL, Shokat KM, Lens SM. Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex. Molecular & Cellular Proteomics : McP. 11: 47-59. PMID 22267324 DOI: 10.1074/Mcp.M111.013912  0.787
2012 Savitt J, Singh D, Zhang C, Chen LC, Folmer J, Shokat KM, Wright WW. The in vivo response of stem and other undifferentiated spermatogonia to the reversible inhibition of glial cell line-derived neurotrophic factor signaling in the adult. Stem Cells (Dayton, Ohio). 30: 732-40. PMID 22232066 DOI: 10.1002/Stem.1028  0.402
2012 Statsuk AV, Shokat KM. Covalent cross-linking of kinases with their corresponding peptide substrates. Methods in Molecular Biology (Clifton, N.J.). 795: 179-90. PMID 21960223 DOI: 10.1007/978-1-61779-337-0_12  0.503
2012 Dorsey SG, Lovering RM, Renn CL, Leitch CC, Liu X, Tallon LJ, Sadzewicz LD, Pratap A, Ott S, Sengamalay N, Jones KM, Barrick C, Fulgenzi G, Becker J, Voelker K, ... ... Shokat K, et al. Genetic deletion of trkB.T1 increases neuromuscular function. American Journal of Physiology. Cell Physiology. 302: C141-53. PMID 21865582 DOI: 10.1152/Ajpcell.00469.2010  0.375
2012 Shuman M, Wells J, Shokat K, Bernales S, Walter P, Shultz L, Goodwin N. A quaternary equation for interdisciplinary medical research (IMR) Journal of Translational Medicine. 10. DOI: 10.1186/1479-5876-10-S2-A49  0.356
2012 Ducker GS, Atreya CE, Shokat KM, Warren RS. Abstract PR4: Incomplete inhibition of phosphorylation of 4EBP1 is a mechanism for KRAS driven resistance to the ATP-competitive mTOR inhibitor PP242 in colorectal cancer Clinical Cancer Research. 18: PR4-PR4. DOI: 10.1158/1078-0432.Mechres-Pr4  0.806
2012 Henderson MN, Malecek KE, Makino DL, Cao XX, Shokat KM, Kuriyan J. Crystal Structure of the Kinase Domain of ABL in Complex with a Potent Rationally-Designed Derivative of the PP1 Inhibitor, AB129 Biophysical Journal. 102: 61a. DOI: 10.1016/J.Bpj.2011.11.363  0.515
2011 Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, Brunet A. Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Molecular Cell. 44: 878-92. PMID 22137581 DOI: 10.1016/J.Molcel.2011.11.005  0.794
2011 Cipak L, Zhang C, Kovacikova I, Rumpf C, Miadokova E, Shokat KM, Gregan J. Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombe. Cell Cycle (Georgetown, Tex.). 10: 3527-32. PMID 22030861 DOI: 10.4161/Cc.10.20.17792  0.56
2011 Artz JD, Wernimont AK, Allali-Hassani A, Zhao Y, Amani M, Lin YH, Senisterra G, Wasney GA, Fedorov O, King O, Roos A, Lunin VV, Qiu W, Finerty P, Hutchinson A, ... ... Shokat K, et al. The Cryptosporidium parvum kinome. Bmc Genomics. 12: 478. PMID 21962082 DOI: 10.1186/1471-2164-12-478  0.548
2011 Schoenborn JR, Tan YX, Zhang C, Shokat KM, Weiss A. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Science Signaling. 4: ra59. PMID 21917715 DOI: 10.1126/Scisignal.2001893  0.488
2011 Wang BT, Ducker GS, Barczak AJ, Barbeau R, Erle DJ, Shokat KM. The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. Proceedings of the National Academy of Sciences of the United States of America. 108: 15201-6. PMID 21876130 DOI: 10.1073/Pnas.1103746108  0.81
2011 Garske AL, Peters U, Cortesi AT, Perez JL, Shokat KM. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proceedings of the National Academy of Sciences of the United States of America. 108: 15046-52. PMID 21852571 DOI: 10.1073/Pnas.1111239108  0.859
2011 Yoshii A, Murata Y, Kim J, Zhang C, Shokat KM, Constantine-Paton M. TrkB and protein kinase Mζ regulate synaptic localization of PSD-95 in developing cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 11894-904. PMID 21849550 DOI: 10.1523/Jneurosci.2190-11.2011  0.402
2011 Salomon D, Zhang C, Shokat KM, Sessa G. Sensitizing plant protein kinases to specific inhibition by ATP-competitive molecules. Methods in Molecular Biology (Clifton, N.J.). 779: 185-97. PMID 21837567 DOI: 10.1007/978-1-61779-264-9_10  0.564
2011 Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. Bmc Biology. 9: 48. PMID 21729334 DOI: 10.1186/1741-7007-9-48  0.487
2011 Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Structural and functional basis for RNA cleavage by Ire1. Bmc Biology. 9: 47. PMID 21729333 DOI: 10.1186/1741-7007-9-47  0.421
2011 Mirzoeva OK, Hann B, Hom YK, Debnath J, Aftab D, Shokat K, Korn WM. Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma Journal of Molecular Medicine. 89: 877-889. PMID 21678117 DOI: 10.1007/S00109-011-0774-Y  0.445
2011 Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP. Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation. Molecular Cell. 42: 624-36. PMID 21658603 DOI: 10.1016/J.Molcel.2011.03.031  0.706
2011 Dar AC, Shokat KM. The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling. Annual Review of Biochemistry. 80: 769-95. PMID 21548788 DOI: 10.1146/Annurev-Biochem-090308-173656  0.807
2011 Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature. 472: 366-9. PMID 21441910 DOI: 10.1038/Nature09860  0.852
2011 Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Research. 71: 106-15. PMID 21199799 DOI: 10.1158/0008-5472.Can-10-2732  0.752
2011 Brennan DF, Dar AC, Hertz NT, Chao W, Burlingame AL, Shokat KM, Barford D. A Raf-Induced Allosteric Transition of Ksr Stimulates Ksr and Raf Phosphorylation of Mek Nature. 472: 366. DOI: 10.2210/Pdb2Y4I/Pdb  0.807
2011 Barkovich KJ, Nicolaides T, Hariono S, Garske A, Fan QW, Shokat K, Weiss WA. Abstract 2314: Erlotinib response in lung- and glioma-derived EGFR alleles: Correlating kinase site occupancy with efficacy Cancer Research. 71: 2314-2314. DOI: 10.1158/1538-7445.Am2011-2314  0.829
2010 Hertz NT, Wang BT, Allen JJ, Zhang C, Dar AC, Burlingame AL, Shokat KM. Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry. Current Protocols in Chemical Biology. 2: 15-36. PMID 23836541 DOI: 10.1002/9780470559277.Ch090201  0.823
2010 Bodenmiller B, Wanka S, Kraft C, Urban J, Campbell D, Pedrioli PG, Gerrits B, Picotti P, Lam H, Vitek O, Brusniak MY, Roschitzki B, Zhang C, Shokat KM, Schlapbach R, et al. Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Science Signaling. 3: rs4. PMID 21177495 DOI: 10.1126/Scisignal.2001182  0.545
2010 Bandyopadhyay S, Mehta M, Kuo D, Sung MK, Chuang R, Jaehnig EJ, Bodenmiller B, Licon K, Copeland W, Shales M, Fiedler D, Dutkowski J, Guénolé A, van Attikum H, Shokat KM, et al. Rewiring of genetic networks in response to DNA damage. Science (New York, N.Y.). 330: 1385-9. PMID 21127252 DOI: 10.1126/Science.1195618  0.589
2010 Chuluunbaatar U, Roller R, Feldman ME, Brown S, Shokat KM, Mohr I. Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication. Genes & Development. 24: 2627-39. PMID 21123650 DOI: 10.1101/Gad.1978310  0.709
2010 Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Science Signaling. 3: ra81. PMID 21062993 DOI: 10.1126/Scisignal.2001017  0.808
2010 Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nature Immunology. 11: 1085-92. PMID 21037577 DOI: 10.1038/Ni.1955  0.497
2010 Su T, Bryant DM, Luton F, Vergés M, Ulrich SM, Hansen KC, Datta A, Eastburn DJ, Burlingame AL, Shokat KM, Mostov KE. A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nature Cell Biology. 12: 1143-53. PMID 21037565 DOI: 10.1038/Ncb2118  0.74
2010 Chou WH, Wang D, McMahon T, Qi ZH, Song M, Zhang C, Shokat KM, Messing RO. GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13955-65. PMID 20962217 DOI: 10.1523/Jneurosci.0270-10.2010  0.377
2010 Gomez-Sjoberg R, Leyrat AA, Houseman BT, Shokat K, Quake SR. Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications. Analytical Chemistry. 82: 8954-60. PMID 20936785 DOI: 10.1021/Ac101870S  0.712
2010 Tietjen JR, Zhang DW, Rodríguez-Molina JB, White BE, Akhtar MS, Heidemann M, Li X, Chapman RD, Shokat K, Keles S, Eick D, Ansari AZ. Chemical-genomic dissection of the CTD code Nature Structural and Molecular Biology. 17: 1154-1161. PMID 20802488 DOI: 10.1038/Nsmb.1900  0.304
2010 Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. The Journal of Cell Biology. 190: 89-100. PMID 20624902 DOI: 10.1083/Jcb.201001050  0.54
2010 Okuzumi T, Ducker GS, Zhang C, Aizenstein B, Hoffman R, Shokat KM. Synthesis and evaluation of indazole based analog sensitive Akt inhibitors. Molecular Biosystems. 6: 1389-402. PMID 20582381 DOI: 10.1039/C003917A  0.861
2010 Feldman ME, Shokat KM. New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs). Current Topics in Microbiology and Immunology. 347: 241-62. PMID 20549474 DOI: 10.1007/82_2010_64  0.762
2010 Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, Sibley LD. Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma. Nature. 465: 359-62. PMID 20485436 DOI: 10.1038/Nature09022  0.482
2010 Sliedrecht T, Zhang C, Shokat KM, Kops GJ. Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. Plos One. 5: e10251. PMID 20422024 DOI: 10.1371/Journal.Pone.0010251  0.343
2010 Shokat KM. A drug-drug interaction crystallizes a new entry point into the UPR. Molecular Cell. 38: 161-3. PMID 20417596 DOI: 10.1016/J.Molcel.2010.04.011  0.303
2010 Amin DN, Sergina N, Ahuja D, McMahon M, Blair JA, Wang D, Hann B, Koch KM, Shokat KM, Moasser MM. Resiliency and vulnerability in the HER2-HER3 tumorigenic driver. Science Translational Medicine. 2: 16ra7. PMID 20371474 DOI: 10.1126/Scitranslmed.3000389  0.699
2010 Miller S, Tavshanjian B, Oleksy A, Perisic O, Houseman BT, Shokat KM, Williams RL. Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science (New York, N.Y.). 327: 1638-42. PMID 20339072 DOI: 10.1126/science.1184429  0.835
2010 Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D. mTOR complex-2 activates ENaC by phosphorylating SGK1. Journal of the American Society of Nephrology : Jasn. 21: 811-8. PMID 20338997 DOI: 10.1681/Asn.2009111168  0.731
2010 Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, Meyuhas O, Shokat KM, Ruggero D. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell. 17: 249-61. PMID 20227039 DOI: 10.1016/J.Ccr.2010.01.021  0.712
2010 Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K. Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents. Proceedings of the National Academy of Sciences of the United States of America. 107: 5106-11. PMID 20194733 DOI: 10.1073/Pnas.1001064107  0.422
2010 Williams O, Houseman BT, Kunkel EJ, Aizenstein B, Hoffman R, Knight ZA, Shokat KM. Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs. Chemistry & Biology. 17: 123-34. PMID 20189103 DOI: 10.1016/J.Chembiol.2010.01.010  0.808
2010 Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature. 464: 427-30. PMID 20179705 DOI: 10.1038/Nature08902  0.533
2010 An S, Kyoung M, Allen JJ, Shokat KM, Benkovic SJ. Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2. The Journal of Biological Chemistry. 285: 11093-9. PMID 20157113 DOI: 10.1074/Jbc.M110.101139  0.707
2010 Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat KM, Shaw JP, et al. The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nature Chemical Biology. 6: 244. PMID 20154668 DOI: 10.1038/Nchembio0310-244B  0.799
2010 Knight ZA, Lin H, Shokat KM. Targeting the cancer kinome through polypharmacology. Nature Reviews. Cancer. 10: 130-7. PMID 20094047 DOI: 10.1038/Nrc2787  0.737
2010 Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat KM, Shaw JP, et al. The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nature Chemical Biology. 6: 117-24. PMID 20081827 DOI: 10.1038/Nchembio.293  0.819
2010 Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF. Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. The Journal of Biological Chemistry. 285: 4278-90. PMID 19996317 DOI: 10.1074/Jbc.M109.036731  0.709
2010 Carlson HK, Plate L, Price MS, Allen JJ, Shokat KM, Marletta MA. Use of a semisynthetic epitope to probe histidine kinase activity and regulation. Analytical Biochemistry. 397: 139-43. PMID 19819215 DOI: 10.1016/J.Ab.2009.10.009  0.684
2010 Poulikakos PI, Zhang C, Joseph EW, Persaud Y, Pratilas CA, Bollag G, Solit DB, Shokat KM, Rosen N. Abstract LB-190: RAF inhibitors transactivate RAF dimers and ERK signaling in a wild-type BRAF-dependent manner Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-190  0.382
2010 Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Roose J, Shokat K, Braun B, Shannon K. Abstract 3837: PI-3 kinase acts upstream of oncogenic Ras in hematopoietic cells through a cytokine-PLCγ-RasGRP pathway Cancer Research. 70: 3837-3837. DOI: 10.1158/1538-7445.Am10-3837  0.48
2010 Nicolaides TP, Barkovich K, Hariono S, Garske A, Fan QW, Shokat K, Weiss WA. Abstract 1973: Targeting activated alleles of EGFR derived from glioma and lung cancer: Correlating kinase active-site occupancy with efficacy Cancer Research. 70: 1973-1973. DOI: 10.1158/1538-7445.Am10-1973  0.827
2010 Amin DN, Sergina N, Ahuja D, McMahon M, Wang D, Hann B, Shokat K, Moasser MM. Abstract 1653: Highly effective treatment of HER2-amplified breast cancers through the complete inactivation of the HER2-HER3 tumorigenic driver Cancer Research. 70: 1653-1653. DOI: 10.1158/1538-7445.Am10-1653  0.393
2010 BISHOP AC, MOORE D, SCANLAN TS, SHOKAT KM. ChemInform Abstract: Screening a Hydroxystilbene Library for Selective Inhibition of the B Cell Antigen Receptor Kinase Cascade. Cheminform. 28: no-no. DOI: 10.1002/chin.199750103  0.646
2010 SHOKAT KM, KO MK, SCANLAN TS, KOCHERSPERGER L, YONKOVICH S, THAISRIVONGS S, SCHULTZ PG. ChemInform Abstract: Catalytic Antibodies: A New Class of Transition-State Analogues Used to Elicit Hydrolytic Antibodies Cheminform. 22: no-no. DOI: 10.1002/chin.199108378  0.538
2009 Niu H, Wan L, Busygina V, Kwon Y, Allen JA, Li X, Kunz RC, Kubota K, Wang B, Sung P, Shokat KM, Gygi SP, Hollingsworth NM. Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation. Molecular Cell. 36: 393-404. PMID 19917248 DOI: 10.1016/J.Molcel.2009.09.029  0.708
2009 Herbert SP, Huisken J, Kim TN, Feldman ME, Houseman BT, Wang RA, Shokat KM, Stainier DY. Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science (New York, N.Y.). 326: 294-8. PMID 19815777 DOI: 10.1126/Science.1178577  0.759
2009 Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stückrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, ... ... Shokat KM, et al. Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proceedings of the National Academy of Sciences of the United States of America. 106: 18351-6. PMID 19805051 DOI: 10.1073/Pnas.0907325106  0.768
2009 Glover-Cutter K, Larochelle S, Erickson B, Zhang C, Shokat K, Fisher RP, Bentley DL. TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. Molecular and Cellular Biology. 29: 5455-64. PMID 19667075 DOI: 10.1128/Mcb.00637-09  0.474
2009 Lartigue Jd, Polson H, Feldman M, Shokat K, Tooze SA, Urbé S, Clague MJ. PIKfyve Regulation of Endosome‐Linked Pathways Traffic. 10: 883-893. PMID 19582903 DOI: 10.1111/J.1600-0854.2009.00915.X  0.421
2009 Liu Y, Warfield L, Zhang C, Luo J, Allen J, Lang WH, Ranish J, Shokat KM, Hahn S. Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. Molecular and Cellular Biology. 29: 4852-63. PMID 19581288 DOI: 10.1128/Mcb.00609-09  0.725
2009 Beltrao P, Trinidad JC, Fiedler D, Roguev A, Lim WA, Shokat KM, Burlingame AL, Krogan NJ. Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. Plos Biology. 7: e1000134. PMID 19547744 DOI: 10.1371/Journal.Pbio.1000134  0.659
2009 Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. Plos Biology. 7: e1000111. PMID 19468302 DOI: 10.1371/Journal.Pbio.1000111  0.512
2009 Okuzumi T, Fiedler D, Zhang C, Gray DC, Aizenstein B, Hoffman R, Shokat KM. Inhibitor hijacking of Akt activation. Nature Chemical Biology. 5: 484-93. PMID 19465931 DOI: 10.1038/Nchembio.183  0.858
2009 Justman QA, Serber Z, Ferrell JE, El-Samad H, Shokat KM. Tuning the activation threshold of a kinase network by nested feedback loops. Science (New York, N.Y.). 324: 509-12. PMID 19390045 DOI: 10.1126/Science.1169498  0.764
2009 Salomon D, Bonshtien A, Mayrose M, Zhang C, Shokat KM, Sessa G. Bypassing kinase activity of the tomato Pto resistance protein with small molecule ligands. The Journal of Biological Chemistry. 284: 15289-98. PMID 19332544 DOI: 10.1074/Jbc.M809724200  0.581
2009 Viladevall L, St Amour CV, Rosebrock A, Schneider S, Zhang C, Allen JJ, Shokat KM, Schwer B, Leatherwood JK, Fisher RP. TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. Molecular Cell. 33: 738-51. PMID 19328067 DOI: 10.1016/J.Molcel.2009.01.029  0.776
2009 Niedermeier M, Hennessy BT, Knight ZA, Henneberg M, Hu J, Kurtova AV, Wierda WG, Keating MJ, Shokat KM, Burger JA. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood. 113: 5549-57. PMID 19318683 DOI: 10.1182/Blood-2008-06-165068  0.737
2009 Wong CH, Baehner FL, Spassov DS, Ahuja D, Wang D, Hann B, Blair J, Shokat K, Welm AL, Moasser MM. Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 2311-22. PMID 19318475 DOI: 10.1158/1078-0432.Ccr-08-2533  0.647
2009 Fiedler D, Braberg H, Mehta M, Chechik G, Cagney G, Mukherjee P, Silva AC, Shales M, Collins SR, van Wageningen S, Kemmeren P, Holstege FC, Weissman JS, Keogh MC, Koller D, ... Shokat KM, et al. Functional organization of the S. cerevisiae phosphorylation network. Cell. 136: 952-63. PMID 19269370 DOI: 10.1016/J.Cell.2008.12.039  0.645
2009 Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. Plos Biology. 7: e38. PMID 19209957 DOI: 10.1371/Journal.Pbio.1000038  0.835
2009 Wang H, Kakaradov B, Collins SR, Karotki L, Fiedler D, Shales M, Shokat KM, Walther TC, Krogan NJ, Koller D. A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Molecular & Cellular Proteomics : McP. 8: 1361-81. PMID 19176519 DOI: 10.1074/Mcp.M800490-Mcp200  0.544
2009 Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. EGFR signals to mTOR through PKC and independently of Akt in glioma. Science Signaling. 2: ra4. PMID 19176518 DOI: 10.1126/Scisignal.2000014  0.781
2009 Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, ... ... Shokat KM, et al. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Research. 69: 565-72. PMID 19147570 DOI: 10.1158/0008-5472.Can-08-3389  0.74
2009 Sly LM, Hamilton MJ, Kuroda E, Ho VW, Antignano FL, Omeis SL, van Netten-Thomas CJ, Wong D, Brugger HK, Williams O, Feldman ME, Houseman BT, Fiedler D, Shokat KM, Krystal G. SHIP prevents lipopolysaccharide from triggering an antiviral response in mice. Blood. 113: 2945-54. PMID 19139077 DOI: 10.1182/Blood-2008-06-166082  0.786
2009 Li S, Makovets S, Matsuguchi T, Blethrow JD, Shokat KM, Blackburn EH. Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell. 136: 50-61. PMID 19135888 DOI: 10.1016/J.Cell.2008.11.027  0.77
2009 Miller AL, Zhang C, Shokat KM, Lowell CA. Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 988-98. PMID 19124742 DOI: 10.4049/Jimmunol.182.2.988  0.538
2009 Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P. The unfolded protein response signals through high-order assembly of Ire1. Nature. 457: 687-93. PMID 19079236 DOI: 10.1038/Nature07661  0.496
2009 Beltrao P, Trinidad JC, Fiedler D, Roguev A, Lim WA, Shokat KM, Burlingame AL, Krogan NJ. Correction: Evolution of Phosphoregulation: Comparison of Phosphorylation Patterns across Yeast Species Plos Biology. 7. DOI: 10.1371/Annotation/66479889-5E57-4213-Bf25-C4E8Cf3D933B  0.55
2009 Diaz-Flores E, Goldschmidt HL, Depeille P, Ng V, Roose J, Shokat K, Braun BS, Shannon K. PI3 Kinase, Phospholipase C (PLC)-γ, and RasGRPs Act Cooperatively to Activate the Ras-Extracellular-Related Kinase (ERK) Pathway in Response to Cytokines in Normal and Kras Mutant Myeloid Cells. Blood. 114: 2512-2512. DOI: 10.1182/Blood.V114.22.2512.2512  0.487
2009 Huskey NE, Horiuchi D, Kusdra L, Zhang C, Shokat K, Goga A. Abstract C68: Using a chemical genetic approach to define the role of CDK2 in normal and transformed cell lines Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-C68  0.482
2009 Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. Erratum: EGFR signals to mTOR through PKC and independently of Akt in glioma (Science Signaling (2009) 2:60 (er4)) Science Signaling. 2. DOI: 10.1126/Scisignal.260Er4  0.711
2008 Morgan DJ, Weisenhaus M, Shum S, Su T, Zheng R, Zhang C, Shokat KM, Hille B, Babcock DF, McKnight GS. Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation. Proceedings of the National Academy of Sciences of the United States of America. 105: 20740-5. PMID 19074277 DOI: 10.1073/Pnas.0810971105  0.524
2008 Merrick KA, Larochelle S, Zhang C, Allen JJ, Shokat KM, Fisher RP. Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells. Molecular Cell. 32: 662-72. PMID 19061641 DOI: 10.1016/J.Molcel.2008.10.022  0.711
2008 Statsuk AV, Maly DJ, Seeliger MA, Fabian MA, Biggs WH, Lockhart DJ, Zarrinkar PP, Kuriyan J, Shokat KM. Tuning a three-component reaction for trapping kinase substrate complexes. Journal of the American Chemical Society. 130: 17568-74. PMID 19053485 DOI: 10.1021/Ja807066F  0.708
2008 Papakonstanti EA, Zwaenepoel O, Bilancio A, Burns E, Nock GE, Houseman B, Shokat K, Ridley AJ, Vanhaesebroeck B. Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages. Journal of Cell Science. 121: 4124-33. PMID 19033389 DOI: 10.1242/Jcs.032763  0.783
2008 Zhang TT, Okkenhaug K, Nashed BF, Puri KD, Knight ZA, Shokat KM, Vanhaesebroeck B, Marshall AJ. Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. The Journal of Allergy and Clinical Immunology. 122: 811-819.e2. PMID 19014771 DOI: 10.1016/J.Jaci.2008.08.008  0.687
2008 Choi DS, Wei W, Deitchman JK, Kharazia VN, Lesscher HM, McMahon T, Wang D, Qi ZH, Sieghart W, Zhang C, Shokat KM, Mody I, Messing RO. Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11890-9. PMID 19005054 DOI: 10.1523/Jneurosci.3156-08.2008  0.312
2008 Kang J, Yang M, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H. Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Molecular Cell. 32: 394-405. PMID 18995837 DOI: 10.1016/J.Molcel.2008.09.017  0.526
2008 Shirra MK, McCartney RR, Zhang C, Shokat KM, Schmidt MC, Arndt KM. A chemical genomics study identifies Snf1 as a repressor of GCN4 translation. The Journal of Biological Chemistry. 283: 35889-98. PMID 18955495 DOI: 10.1074/Jbc.M805325200  0.479
2008 Dar AC, Lopez MS, Shokat KM. Small molecule recognition of c-Src via the Imatinib-binding conformation. Chemistry & Biology. 15: 1015-22. PMID 18940662 DOI: 10.1016/J.Chembiol.2008.09.007  0.816
2008 Chaisuparat R, Hu J, Jham BC, Knight ZA, Shokat KM, Montaner S. Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma. Cancer Research. 68: 8361-8. PMID 18922908 DOI: 10.1158/0008-5472.Can-08-0878  0.691
2008 Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, Hoffman R, Williams RL, Shokat KM, Knight ZA. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nature Chemical Biology. 4: 691-9. PMID 18849971 DOI: 10.1038/Nchembio.117  0.851
2008 Kurischko C, Kuravi VK, Wannissorn N, Nazarov PA, Husain M, Zhang C, Shokat KM, McCaffery JM, Luca FC. The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion. Molecular Biology of the Cell. 19: 5559-78. PMID 18843045 DOI: 10.1091/Mbc.E08-05-0455  0.457
2008 Oda K, Okada J, Timmerman L, Rodriguez-Viciana P, Stokoe D, Shoji K, Taketani Y, Kuramoto H, Knight ZA, Shokat KM, McCormick F. PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation. Cancer Research. 68: 8127-36. PMID 18829572 DOI: 10.1158/0008-5472.Can-08-0755  0.662
2008 Bateman RL, Rauh D, Tavshanjian B, Shokat KM. Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. The Journal of Biological Chemistry. 283: 35756-62. PMID 18826943 DOI: 10.1074/Jbc.M807125200  0.786
2008 Kim JS, Lilley BN, Zhang C, Shokat KM, Sanes JR, Zhen M. A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation. Neural Development. 3: 23. PMID 18808695 DOI: 10.1186/1749-8104-3-23  0.4
2008 Lu X, Simon MD, Chodaparambil JV, Hansen JC, Shokat KM, Luger K. The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure. Nature Structural & Molecular Biology. 15: 1122-4. PMID 18794842 DOI: 10.1038/Nsmb.1489  0.556
2008 Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. The Journal of Clinical Investigation. 118: 3038-50. PMID 18704194 DOI: 10.1172/Jci33337  0.698
2008 Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat KM. Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha. Cancer Cell. 14: 180-92. PMID 18691552 DOI: 10.1016/J.Ccr.2008.06.014  0.811
2008 Johnson AW, Chen X, Crombag HS, Zhang C, Smith DR, Shokat KM, Gallagher M, Holland PC, Ginty DD. The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value. The European Journal of Neuroscience. 28: 997-1002. PMID 18671735 DOI: 10.1111/J.1460-9568.2008.06383.X  0.336
2008 Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D. Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. American Journal of Physiology. Renal Physiology. 295: F843-50. PMID 18653476 DOI: 10.1152/Ajprenal.90348.2008  0.819
2008 Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, Proctor M, Shokat KM, Zhang C, Davis RW, Giaever G, St Onge RP, StOnge RP, Nislow C. An integrated platform of genomic assays reveals small-molecule bioactivities. Nature Chemical Biology. 4: 498-506. PMID 18622389 DOI: 10.1038/Nchembio.100  0.426
2008 Kim HH, Abdelmohsen K, Lal A, Pullmann R, Yang X, Galban S, Srikantan S, Martindale JL, Blethrow J, Shokat KM, Gorospe M. Nuclear HuR accumulation through phosphorylation by Cdk1. Genes & Development. 22: 1804-15. PMID 18593881 DOI: 10.1101/Gad.1645808  0.784
2008 Sordet O, Larochelle S, Nicolas E, Stevens EV, Zhang C, Shokat KM, Fisher RP, Pommier Y. Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I. Journal of Molecular Biology. 381: 540-9. PMID 18588899 DOI: 10.1016/J.Jmb.2008.06.028  0.391
2008 Park S, Chapuis N, Bardet V, Tamburini J, Gallay N, Willems L, Knight ZA, Shokat KM, Azar N, Viguié F, Ifrah N, Dreyfus F, Mayeux P, Lacombe C, Bouscary D. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. Leukemia. 22: 1698-706. PMID 18548104 DOI: 10.1038/Leu.2008.144  0.713
2008 Tamgüney T, Zhang C, Fiedler D, Shokat K, Stokoe D. Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells. Experimental Cell Research. 314: 2299-312. PMID 18514190 DOI: 10.1016/J.Yexcr.2008.04.006  0.738
2008 Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, Knight ZA, Cobb BS, Cantrell D, O'Connor E, Shokat KM, Fisher AG, Merkenschlager M. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proceedings of the National Academy of Sciences of the United States of America. 105: 7797-802. PMID 18509048 DOI: 10.1073/Pnas.0800928105  0.675
2008 Torbett NE, Luna-Moran A, Knight ZA, Houk A, Moasser M, Weiss W, Shokat KM, Stokoe D. A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. The Biochemical Journal. 415: 97-110. PMID 18498248 DOI: 10.1042/Bj20080639  0.781
2008 Chen JS, Zhou LJ, Entin-Meer M, Yang X, Donker M, Knight ZA, Weiss W, Shokat KM, Haas-Kogan D, Stokoe D. Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Molecular Cancer Therapeutics. 7: 841-50. PMID 18413797 DOI: 10.1158/1535-7163.Mct-07-0393  0.764
2008 Levin SE, Zhang C, Kadlecek TA, Shokat KM, Weiss A. Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. The Journal of Biological Chemistry. 283: 15419-30. PMID 18378687 DOI: 10.1074/Jbc.M709000200  0.488
2008 Wan L, Niu H, Futcher B, Zhang C, Shokat KM, Boulton SJ, Hollingsworth NM. Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. Genes & Development. 22: 386-97. PMID 18245450 DOI: 10.1101/Gad.1626408  0.472
2008 Blethrow JD, Glavy JS, Morgan DO, Shokat KM. Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proceedings of the National Academy of Sciences of the United States of America. 105: 1442-7. PMID 18234856 DOI: 10.1073/Pnas.0708966105  0.803
2008 Balla A, Tuymetova G, Toth B, Szentpetery Z, Zhao X, Knight ZA, Shokat K, Steinbach PJ, Balla T. Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling. Biochemistry. 47: 1599-607. PMID 18205404 DOI: 10.1021/Bi7017927  0.696
2008 Balla A, Kim YJ, Varnai P, Szentpetery Z, Knight Z, Shokat KM, Balla T. Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Molecular Biology of the Cell. 19: 711-21. PMID 18077555 DOI: 10.1091/Mbc.E07-07-0713  0.656
2008 Rubenstein EM, McCartney RR, Zhang C, Shokat KM, Shirra MK, Arndt KM, Schmidt MC. Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. The Journal of Biological Chemistry. 283: 222-30. PMID 17991748 DOI: 10.1074/Jbc.M707957200  0.458
2008 Kasap C, Hertz N, Makino D, Shokat K, Kuriyan J, Shah NP. Beyond the Gatekeeper: Imatinib- and Dasatinib-Resistant BCR-ABL/F317 Mutations Confer Cross-Resistance to VX-680 but Are Sensitive to a Structural Derivative of VX-680 Blood. 112: 725-725. DOI: 10.1182/Blood.V112.11.725.725  0.783
2008 Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, Proctor M, Shokat KM, Zhang C, Davis RW, Giaever G, St Onge RP, Nislow C. An integrated platform of genomic assays reveals small-molecule bioactivities (Nature Chemical Biology (2008) 4, (498-506)) Nature Chemical Biology. 4: 632. DOI: 10.1038/Nchembio1008-632  0.301
2008 Juris SJ, Shah K, Shokat K, Dixon JE, Vacratsis PO. Corrigendum to "Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry" [FEBS Lett. 580 (2006) 179-183] (DOI:10.1016/j.febslet.2005.11.071) Febs Letters. 582: 3159. DOI: 10.1016/J.Febslet.2008.07.053  0.584
2008 Simon MD, Shokat KM. Engineering Control Over Protein Function Using Chemistry: Revealing Biological Specificity by Engineering Protein-Ligand Interactions Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 1: 115-139. DOI: 10.1002/9783527619375.ch3a  0.528
2007 Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chemistry & Biology. 14: 1261-72. PMID 18022565 DOI: 10.1016/J.Chembiol.2007.09.011  0.857
2007 Weiss WA, Taylor SS, Shokat KM. Recognizing and exploiting differences between RNAi and small-molecule inhibitors. Nature Chemical Biology. 3: 739-44. PMID 18007642 DOI: 10.1038/Nchembio1207-739  0.511
2007 Gregan J, Zhang C, Rumpf C, Cipak L, Li Z, Uluocak P, Nasmyth K, Shokat KM. Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe. Nature Protocols. 2: 2996-3000. PMID 18007635 DOI: 10.1038/Nprot.2007.447  0.577
2007 Hung CH, Thomas L, Ruby CE, Atkins KM, Morris NP, Knight ZA, Scholz I, Barklis E, Weinberg AD, Shokat KM, Thomas G. HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. Cell Host & Microbe. 1: 121-33. PMID 18005690 DOI: 10.1016/J.Chom.2007.03.004  0.697
2007 Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM, Walter P. IRE1 signaling affects cell fate during the unfolded protein response. Science (New York, N.Y.). 318: 944-9. PMID 17991856 DOI: 10.1126/Science.1146361  0.464
2007 Knight ZA, Feldman ME, Balla A, Balla T, Shokat KM. A membrane capture assay for lipid kinase activity. Nature Protocols. 2: 2459-66. PMID 17947987 DOI: 10.1038/Nprot.2007.361  0.805
2007 Bateman R, Rauh D, Shokat KM. Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct. Organic & Biomolecular Chemistry. 5: 3363-7. PMID 17912391 DOI: 10.1039/B707602A  0.773
2007 Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. A surface on the androgen receptor that allosterically regulates coactivator binding. Proceedings of the National Academy of Sciences of the United States of America. 104: 16074-9. PMID 17911242 DOI: 10.1073/Pnas.0708036104  0.795
2007 Das M, Jiang F, Sluss HK, Zhang C, Shokat KM, Flavell RA, Davis RJ. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 15759-64. PMID 17893331 DOI: 10.1073/Pnas.0707782104  0.41
2007 Qi ZH, Song M, Wallace MJ, Wang D, Newton PM, McMahon T, Chou WH, Zhang C, Shokat KM, Messing RO. Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. The Journal of Biological Chemistry. 282: 33052-63. PMID 17875639 DOI: 10.1074/Jbc.M707233200  0.387
2007 Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA. A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Research. 67: 7960-5. PMID 17804702 DOI: 10.1158/0008-5472.Can-07-2154  0.759
2007 Knight ZA, Garrison JL, Chan K, King DS, Shokat KM. A remodelled protease that cleaves phosphotyrosine substrates. Journal of the American Chemical Society. 129: 11672-3. PMID 17803306 DOI: 10.1021/Ja073875N  0.648
2007 Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick SM, Shokat KM. A semisynthetic epitope for kinase substrates. Nature Methods. 4: 511-6. PMID 17486086 DOI: 10.1038/Nmeth1048  0.847
2007 Kanin EI, Kipp RT, Kung C, Slattery M, Viale A, Hahn S, Shokat KM, Ansari AZ. Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 5812-7. PMID 17392431 DOI: 10.1073/Pnas.0611505104  0.455
2007 Larochelle S, Merrick KA, Terret ME, Wohlbold L, Barboza NM, Zhang C, Shokat KM, Jallepalli PV, Fisher RP. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molecular Cell. 25: 839-50. PMID 17386261 DOI: 10.1016/J.Molcel.2007.02.003  0.509
2007 Knight ZA, Shokat KM. Chemically targeting the PI3K family. Biochemical Society Transactions. 35: 245-9. PMID 17371250 DOI: 10.1042/Bst0350245  0.716
2007 Burkard ME, Randall CL, Larochelle S, Zhang C, Shokat KM, Fisher RP, Jallepalli PV. Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 4383-8. PMID 17360533 DOI: 10.1073/Pnas.0701140104  0.506
2007 Simon MD, Chu F, Racki LR, de la Cruz CC, Burlingame AL, Panning B, Narlikar GJ, Shokat KM. The site-specific installation of methyl-lysine analogs into recombinant histones. Cell. 128: 1003-12. PMID 17350582 DOI: 10.1016/j.cell.2006.12.041  0.515
2007 Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat KM. Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nature Chemical Biology. 3: 229-38. PMID 17334377 DOI: 10.1038/Nchembio866  0.857
2007 Knight ZA, Shokat KM. Chemical genetics: where genetics and pharmacology meet. Cell. 128: 425-30. PMID 17289560 DOI: 10.1016/J.Cell.2007.01.021  0.616
2007 Sergina NV, Rausch M, Wang D, Blair J, Hann B, Shokat KM, Moasser MM. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature. 445: 437-41. PMID 17206155 DOI: 10.1038/Nature05474  0.72
2007 Rauh D, Blair J, Shokat K. Structure guided Development of Functional Probes for Protein Kinases using Chemical Genetics Gbm Fall Meeting Hamburg 2007. 2007. DOI: 10.1240/sav_gbm_2007_h_002053  0.589
2007 Park S, Chapuis N, Bardet V, Willems L, Tamburini J, Knight ZA, Shokat KM, Azar N, Ifrah N, Dreyfus F, Mayeux P, Lacombe C, Bouscary D. PI-103, a Dual Inhibitor of Class I Phosphatidylinositide 3-Kinase and mTOR, Has Anti-Leukemic Activity in Acute Myeloid Leukemia. Blood. 110: 876-876. DOI: 10.1182/Blood.V110.11.876.876  0.726
2007 Niedermeier MT, Rawluk J, Knight Z, Shokat K, Wierda WG, Keating MJ, Burger JA. Importance of PI3 Kinase Family for Crosstalk between Chronic Lymphocytic Leukemia B Cells and the Stromal Microenvironment: Therapeutic Implications. Blood. 110: 1125-1125. DOI: 10.1182/Blood.V110.11.1125.1125  0.684
2007 Estébanez-Perpiñá E, Arnold LA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. Erratum: A surface on the androgen receptor that allosterically regulates coactivator binding (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, 41, (16074-16079) DOI: 10.1073/pnas. 0708036104) Proceedings of the National Academy of Sciences of the United States of America. 104. DOI: 10.1073/Pnas.0709913104  0.766
2007 Zhang C, Shokat KM. Enhanced selectivity for inhibition of analog-sensitive protein kinases through scaffold optimization Tetrahedron. 63: 5832-5838. DOI: 10.1016/J.Tet.2007.02.089  0.587
2006 Simon MD, Feldman ME, Rauh D, Maris AE, Wemmer DE, Shokat KM. Structure and properties of a re-engineered homeodomain protein-DNA interface. Acs Chemical Biology. 1: 755-60. PMID 17240973 DOI: 10.1021/Cb6003756  0.781
2006 Allen JJ, Shokat KM. Chemical genomics: dialed in transcriptional network control with non-steroidal glucocorticoid receptor modulators. Acs Chemical Biology. 1: 139-40. PMID 17163659 DOI: 10.1021/Cb600137R  0.567
2006 Wan L, Zhang C, Shokat KM, Hollingsworth NM. Chemical inactivation of cdc7 kinase in budding yeast results in a reversible arrest that allows efficient cell synchronization prior to meiotic recombination. Genetics. 174: 1767-74. PMID 17057233 DOI: 10.1534/Genetics.106.064303  0.503
2006 Tóth B, Balla A, Ma H, Knight ZA, Shokat KM, Balla T. Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi. The Journal of Biological Chemistry. 281: 36369-77. PMID 17003043 DOI: 10.1074/Jbc.M604935200  0.716
2006 Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat KM, Davis RJ. JNK2 is a positive regulator of the cJun transcription factor. Molecular Cell. 23: 899-911. PMID 16973441 DOI: 10.1016/J.Molcel.2006.07.028  0.463
2006 Van Keymeulen A, Wong K, Knight ZA, Govaerts C, Hahn KM, Shokat KM, Bourne HR. To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. The Journal of Cell Biology. 174: 437-45. PMID 16864657 DOI: 10.1083/Jcb.200604113  0.662
2006 Brodersen P, Petersen M, Bjørn Nielsen H, Zhu S, Newman MA, Shokat KM, Rietz S, Parker J, Mundy J. Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4. The Plant Journal : For Cell and Molecular Biology. 47: 532-46. PMID 16813576 DOI: 10.1111/J.1365-313X.2006.02806.X  0.324
2006 Wei F, Wang GD, Zhang C, Shokat KM, Wang H, Tsien JZ, Liauw J, Zhuo M. Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia. Molecular Pain. 2: 21. PMID 16776832 DOI: 10.1186/1744-8069-2-21  0.385
2006 Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 9: 341-9. PMID 16697955 DOI: 10.1016/J.Ccr.2006.03.029  0.797
2006 Sturgeon CM, Knight ZA, Shokat KM, Roberge M. Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage. Molecular Cancer Therapeutics. 5: 885-92. PMID 16648558 DOI: 10.1158/1535-7163.Mct-05-0358  0.641
2006 Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 125: 733-47. PMID 16647110 DOI: 10.1016/J.Cell.2006.03.035  0.814
2006 Kung C, Kenski DM, Krukenberg K, Madhani HD, Shokat KM. Selective kinase inhibition by exploiting differential pathway sensitivity. Chemistry & Biology. 13: 399-407. PMID 16632252 DOI: 10.1016/J.Chembiol.2006.02.004  0.823
2006 Wohlbold L, Larochelle S, Liao JC, Livshits G, Singer J, Shokat KM, Fisher RP. The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity. Cell Cycle (Georgetown, Tex.). 5: 546-54. PMID 16552187 DOI: 10.4161/Cc.5.5.2541  0.458
2006 Ventura JJ, Hübner A, Zhang C, Flavell RA, Shokat KM, Davis RJ. Chemical genetic analysis of the time course of signal transduction by JNK. Molecular Cell. 21: 701-10. PMID 16507367 DOI: 10.1016/J.Molcel.2006.01.018  0.406
2006 Juris SJ, Shah K, Shokat K, Dixon JE, Vacratsis PO. Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry. Febs Letters. 580: 179-83. PMID 16364312 DOI: 10.1016/J.Febslet.2005.11.071  0.591
2006 Larochelle S, Batliner J, Gamble MJ, Barboza NM, Kraybill BC, Blethrow JD, Shokat KM, Fisher RP. Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nature Structural & Molecular Biology. 13: 55-62. PMID 16327805 DOI: 10.1038/Nsmb1028  0.832
2006 Pinsky BA, Kung C, Shokat KM, Biggins S. The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores. Nature Cell Biology. 8: 78-83. PMID 16327780 DOI: 10.1038/Ncb1341  0.4
2006 Knight ZA, Shokat KM. Knock-outs and inhibitors: One and the same? Blood. 107: 420-421. DOI: 10.1182/Blood-2005-10-4264  0.714
2006 Wei W, Bateman R, Rauh D, Li B, Shokat KM, Liu L. P0119. Pharmacological inhibitors of S-nitroso-glutathione reductase Nitric Oxide. 14: 55-56. DOI: 10.1016/J.Niox.2006.04.185  0.792
2006 Bateman R, Rauh D, Shokat K. Progress Toward the Development of Inhibitors of 11beta-Hydroxysteroid dehydrogenase 2: Inhibition of Cortisol Catabolism in the Lung Journal of Allergy and Clinical Immunology. 117: S91. DOI: 10.1016/J.Jaci.2005.12.363  0.555
2005 Dephoure N, Howson RW, Blethrow JD, Shokat KM, O'Shea EK. Combining chemical genetics and proteomics to identify protein kinase substrates. Proceedings of the National Academy of Sciences of the United States of America. 102: 17940-5. PMID 16330754 DOI: 10.1073/Pnas.0509080102  0.818
2005 Kenski DM, Zhang C, von Zastrow M, Shokat KM. Chemical genetic engineering of G protein-coupled receptor kinase 2. The Journal of Biological Chemistry. 280: 35051-61. PMID 16081410 DOI: 10.1074/Jbc.M507594200  0.8
2005 D'Aquino KE, Monje-Casas F, Paulson J, Reiser V, Charles GM, Lai L, Shokat KM, Amon A. The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Molecular Cell. 19: 223-34. PMID 16039591 DOI: 10.1016/J.Molcel.2005.06.005  0.755
2005 Knight ZA, Shokat KM. Features of selective kinase inhibitors. Chemistry & Biology. 12: 621-37. PMID 15975507 DOI: 10.1016/J.Chembiol.2005.04.011  0.737
2005 Cohen MS, Zhang C, Shokat KM, Taunton J. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science (New York, N.Y.). 308: 1318-21. PMID 15919995 DOI: 10.1126/Science1108367  0.516
2005 Zhang C, Kenski DM, Paulson JL, Bonshtien A, Sessa G, Cross JV, Templeton DJ, Shokat KM. A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases. Nature Methods. 2: 435-41. PMID 15908922 DOI: 10.1038/Nmeth764  0.856
2005 Allen JJ, Lazerwith SE, Shokat KM. Bio-orthogonal affinity purification of direct kinase substrates. Journal of the American Chemical Society. 127: 5288-9. PMID 15826144 DOI: 10.1021/Ja050727T  0.839
2005 Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 46: 13-21. PMID 15820690 DOI: 10.1016/J.Neuron.2005.03.009  0.488
2005 Tanaka M, Bateman R, Rauh D, Vaisberg E, Ramachandani S, Zhang C, Hansen KC, Burlingame AL, Trautman JK, Shokat KM, Adams CL. An unbiased cell morphology-based screen for new, biologically active small molecules. Plos Biology. 3: e128. PMID 15799708 DOI: 10.1371/Journal.Pbio.0030128  0.844
2005 Alaimo PJ, Knight ZA, Shokat KM. Targeting the gatekeeper residue in phosphoinositide 3-kinases. Bioorganic & Medicinal Chemistry. 13: 2825-36. PMID 15781393 DOI: 10.1016/J.Bmc.2005.02.021  0.857
2005 Kung C, Kenski DM, Dickerson SH, Howson RW, Kuyper LF, Madhani HD, Shokat KM. Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 102: 3587-92. PMID 15738404 DOI: 10.1073/Pnas.0407170102  0.827
2005 Kung C, Shokat KM. Small-molecule kinase-inhibitor target assessment. Chembiochem : a European Journal of Chemical Biology. 6: 523-6. PMID 15696508 DOI: 10.1002/Cbic.200400393  0.509
2005 Jones MH, Huneycutt BJ, Pearson CG, Zhang C, Morgan G, Shokat K, Bloom K, Winey M. Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis. Current Biology : Cb. 15: 160-5. PMID 15668173 DOI: 10.1016/J.Cub.2005.01.010  0.46
2004 Blethrow J, Zhang C, Shokat KM, Weiss EL. Design and use of analog-sensitive protein kinases. Current Protocols in Molecular Biology. Unit 18.11. PMID 18265343 DOI: 10.1002/0471142727.Mb1811S66  0.833
2004 Wong S, McLaughlin J, Cheng D, Zhang C, Shokat KM, Witte ON. Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations. Proceedings of the National Academy of Sciences of the United States of America. 101: 17456-61. PMID 15505216 DOI: 10.1073/Pnas.0407061101  0.507
2004 Knight ZA, Chiang GG, Alaimo PJ, Kenski DM, Ho CB, Coan K, Abraham RT, Shokat KM. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorganic & Medicinal Chemistry. 12: 4749-59. PMID 15358300 DOI: 10.1016/J.Bmc.2004.06.022  0.829
2004 Kunkel EJ, Plavec I, Nguyen D, Melrose J, Rosler ES, Kao LT, Wang Y, Hytopoulos E, Bishop AC, Bateman R, Shokat KM, Butcher EC, Berg EL. Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models. Assay and Drug Development Technologies. 2: 431-41. PMID 15357924 DOI: 10.1089/Adt.2004.2.431  0.836
2004 Maly DJ, Allen JA, Shokat KM. A mechanism-based cross-linker for the identification of kinase-substrate pairs. Journal of the American Chemical Society. 126: 9160-1. PMID 15281787 DOI: 10.1021/Ja048659I  0.687
2004 Sato K, Simon MD, Levin AM, Shokat KM, Weiss GA. Dissecting the Engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning. Chemistry & Biology. 11: 1017-23. PMID 15271360 DOI: 10.1016/J.Chembiol.2004.05.008  0.583
2004 Simon MD, Sato K, Weiss GA, Shokat KM. A phage display selection of engrailed homeodomain mutants and the importance of residue Q50. Nucleic Acids Research. 32: 3623-31. PMID 15247345 DOI: 10.1093/Nar/Gkh690  0.586
2004 Simon MD, Shokat KM. Adaptability at a protein-DNA interface: re-engineering the engrailed homeodomain to recognize an unnatural nucleotide. Journal of the American Chemical Society. 126: 8078-9. PMID 15225024 DOI: 10.1021/Ja048113W  0.566
2004 Provance DW, Gourley CR, Silan CM, Cameron LC, Shokat KM, Goldenring JR, Shah K, Gillespie PG, Mercer JA. Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic. Proceedings of the National Academy of Sciences of the United States of America. 101: 1868-73. PMID 14766983 DOI: 10.1073/Pnas.0305895101  0.536
2004 Liu Y, Kung C, Fishburn J, Ansari AZ, Shokat KM, Hahn S. Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex. Molecular and Cellular Biology. 24: 1721-35. PMID 14749387 DOI: 10.1128/Mcb.24.4.1721-1735.2004  0.756
2004 Hindley AD, Park S, Wang L, Shah K, Wang Y, Hu X, Shokat KM, Kolch W, Sedivy JM, Yeung KC. Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position. Febs Letters. 556: 26-34. PMID 14706820 DOI: 10.1016/S0014-5793(03)01352-8  0.659
2004 Wan L, de los Santos T, Zhang C, Shokat K, Hollingsworth NM. Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast. Molecular Biology of the Cell. 15: 11-23. PMID 14595109 DOI: 10.1091/Mbc.E03-07-0499  0.56
2003 Fan QW, Specht KM, Zhang C, Goldenberg DD, Shokat KM, Weiss WA. Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. Cancer Research. 63: 8930-8. PMID 14695210  0.85
2003 Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO. Targets of the cyclin-dependent kinase Cdk1. Nature. 425: 859-64. PMID 14574415 DOI: 10.1038/Nature02062  0.832
2003 Papa FR, Zhang C, Shokat K, Walter P. Bypassing a kinase activity with an ATP-competitive drug. Science (New York, N.Y.). 302: 1533-7. PMID 14564015 DOI: 10.1126/Science.1090031  0.542
2003 Sekiya-Kawasaki M, Groen AC, Cope MJ, Kaksonen M, Watson HA, Zhang C, Shokat KM, Wendland B, McDonald KL, McCaffery JM, Drubin DG. Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. The Journal of Cell Biology. 162: 765-72. PMID 12952930 DOI: 10.1083/Jcb.200305077  0.389
2003 Knight ZA, Schilling B, Row RH, Kenski DM, Gibson BW, Shokat KM. Phosphospecific proteolysis for mapping sites of protein phosphorylation. Nature Biotechnology. 21: 1047-54. PMID 12923550 DOI: 10.1038/Nbt863  0.811
2003 Sreenivasan A, Bishop AC, Shokat KM, Kellogg DR. Specific inhibition of Elm1 kinase activity reveals functions required for early G1 events. Molecular and Cellular Biology. 23: 6327-37. PMID 12917352 DOI: 10.1128/Mcb.23.17.6327-6337.2003  0.712
2003 Denzel A, Hare KJ, Zhang C, Shokat K, Jenkinson EJ, Anderson G, Hayday A. Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development. Journal of Immunology (Baltimore, Md. : 1950). 171: 519-23. PMID 12847211 DOI: 10.4049/Jimmunol.171.2.519  0.545
2003 Shah K, Shokat KM. A chemical genetic approach for the identification of direct substrates of protein kinases. Methods in Molecular Biology (Clifton, N.J.). 233: 253-71. PMID 12840513 DOI: 10.1385/1-59259-397-6:253  0.596
2003 Ulrich SM, Kenski DM, Shokat KM. Engineering a "methionine clamp" into Src family kinases enhances specificity toward unnatural ATP analogues. Biochemistry. 42: 7915-21. PMID 12834343 DOI: 10.1021/Bi030042A  0.84
2003 Benjamin KR, Zhang C, Shokat KM, Herskowitz I. Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. Genes & Development. 17: 1524-39. PMID 12783856 DOI: 10.1101/Gad.1101503  0.491
2003 Wang H, Shimizu E, Tang YP, Cho M, Kyin M, Zuo W, Robinson DA, Alaimo PJ, Zhang C, Morimoto H, Zhuo M, Feng R, Shokat KM, Tsien JZ. Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain. Proceedings of the National Academy of Sciences of the United States of America. 100: 4287-92. PMID 12646704 DOI: 10.1073/Pnas.0636870100  0.797
2003 Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ. Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. The Journal of Biological Chemistry. 278: 14926-35. PMID 12594221 DOI: 10.1074/Jbc.M300485200  0.672
2003 Abeliovich H, Zhang C, Dunn WA, Shokat KM, Klionsky DJ. Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Molecular Biology of the Cell. 14: 477-90. PMID 12589048 DOI: 10.1091/Mbc.E02-07-0413  0.488
2003 Shokat K, Velleca M. Novel chemical genetic approaches to the discovery of signal transduction inhibitors. Drug Discovery Today. 7: 872-9. PMID 12546954 DOI: 10.1016/S1359-6446(02)02391-7  0.375
2002 Alaimo PJ, Shogren-Knaak MA, Shokat KM. Chemical Genetic Analysis of Protein Kinase Cascades. Thescientificworldjournal. 2: 108-110. PMID 29973826 DOI: 10.1100/Tsw.2002.51  0.809
2002 Ulrich SM, Sallee NA, Shokat KM. Conformational restraint is a critical determinant of unnatural nucleotide recognition by protein kinases. Bioorganic & Medicinal Chemistry Letters. 12: 3223-7. PMID 12372539 DOI: 10.1016/S0960-894X(02)00616-9  0.693
2002 Kraybill BC, Elkin LL, Blethrow JD, Morgan DO, Shokat KM. Inhibitor scaffolds as new allele specific kinase substrates. Journal of the American Chemical Society. 124: 12118-28. PMID 12371851 DOI: 10.1021/Ja0264798  0.838
2002 Buzko O, Shokat KM. A kinase sequence database: sequence alignments and family assignment. Bioinformatics (Oxford, England). 18: 1274-5. PMID 12217924 DOI: 10.1093/Bioinformatics/18.9.1274  0.806
2002 Weiss EL, Kurischko C, Zhang C, Shokat K, Drubin DG, Luca FC. The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. The Journal of Cell Biology. 158: 885-900. PMID 12196508 DOI: 10.1083/Jcb.200203094  0.442
2002 Fan QW, Zhang C, Shokat KM, Weiss WA. Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling. Current Biology : Cb. 12: 1386-94. PMID 12194819 DOI: 10.1016/S0960-9822(02)01070-9  0.703
2002 Buzko OV, Bishop AC, Shokat KM. Modified AutoDock for accurate docking of protein kinase inhibitors. Journal of Computer-Aided Molecular Design. 16: 113-27. PMID 12188021 DOI: 10.1023/A:1016366013656  0.844
2002 Ulrich S, Shokat K. Green fluorescent protein-based protein kinase biosensor substrates Methods in Molecular Biology (Clifton, N.J.). 183: 275-285. PMID 12136762 DOI: 10.1385/1-59259-280-5:275  0.689
2002 Niswender CM, Ishihara RW, Judge LM, Zhang C, Shokat KM, McKnight GS. Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity. The Journal of Biological Chemistry. 277: 28916-22. PMID 12034735 DOI: 10.1074/Jbc.M203327200  0.576
2002 Specht KM, Shokat KM. The emerging power of chemical genetics. Current Opinion in Cell Biology. 14: 155-9. PMID 11891113 DOI: 10.1016/S0955-0674(02)00317-4  0.815
2002 Holt JR, Gillespie SK, Provance DW, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PG. A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Cell. 108: 371-81. PMID 11853671 DOI: 10.1016/S0092-8674(02)00629-3  0.504
2002 Shah K, Shokat KM. A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. Chemistry & Biology. 9: 35-47. PMID 11841937 DOI: 10.1016/S1074-5521(02)00086-8  0.595
2002 Witucki LA, Huang X, Shah K, Liu Y, Kyin S, Eck MJ, Shokat KM. Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chemistry & Biology. 9: 25-33. PMID 11841936 DOI: 10.1016/S1074-5521(02)00091-1  0.843
2001 Ting AY, Witte K, Shah K, Kraybill B, Shokat KM, Schultz PG. Phage-display evolution of tyrosine kinases with altered nucleotide specificity. Biopolymers. 60: 220-8. PMID 11774228 DOI: 10.1002/1097-0282(2001)60:3<220::Aid-Bip10035>3.0.Co;2-C  0.846
2001 Shogren-Knaak MA, Alaimo PJ, Shokat KM. Recent advances in chemical approaches to the study of biological systems. Annual Review of Cell and Developmental Biology. 17: 405-33. PMID 11687495 DOI: 10.1146/Annurev.Cellbio.17.1.405  0.789
2001 Carroll AS, Bishop AC, DeRisi JL, Shokat KM, O'Shea EK. Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response. Proceedings of the National Academy of Sciences of the United States of America. 98: 12578-83. PMID 11675494 DOI: 10.1073/Pnas.211195798  0.713
2001 Alaimo PJ, Shogren-Knaak MA, Shokat KM. Chemical genetic approaches for the elucidation of signaling pathways. Current Opinion in Chemical Biology. 5: 360-7. PMID 11470597 DOI: 10.1016/S1367-5931(00)00215-5  0.802
2001 Bishop AC, Buzko O, Shokat KM. Magic bullets for protein kinases. Trends in Cell Biology. 11: 167-72. PMID 11306297 DOI: 10.1016/S0962-8924(01)01928-6  0.858
2001 Habelhah H, Shah K, Huang L, Burlingame AL, Shokat KM, Ronai Z. Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue. The Journal of Biological Chemistry. 276: 18090-5. PMID 11259409 DOI: 10.1074/Jbc.M011396200  0.595
2001 Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, Hentze MW, Ronai Z. ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. Nature Cell Biology. 3: 325-30. PMID 11231586 DOI: 10.1038/35060131  0.584
2000 Liu Y, Witucki LA, Shah K, Bishop AC, Shokat KM. Src-Abl tyrosine kinase chimeras: replacement of the adenine binding pocket of c-Abl with v-Src to swap nucleotide and inhibitor specificities. Biochemistry. 39: 14400-8. PMID 11087392 DOI: 10.1021/Bi000437J  0.841
2000 Weiss EL, Bishop AC, Shokat KM, Drubin DG. Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p. Nature Cell Biology. 2: 677-85. PMID 11025657 DOI: 10.1038/35036300  0.71
2000 Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J, Shimizu E, Tsien JZ, Schultz PG, Rose MD, Wood JL, Morgan DO, Shokat KM. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 407: 395-401. PMID 11014197 DOI: 10.1038/35030148  0.861
2000 Bishop A, Buzko O, Heyeck-Dumas S, Jung I, Kraybill B, Liu Y, Shah K, Ulrich S, Witucki L, Yang F, Zhang C, Shokat KM. Unnatural ligands for engineered proteins: new tools for chemical genetics. Annual Review of Biophysics and Biomolecular Structure. 29: 577-606. PMID 10940260 DOI: 10.1146/Annurev.Biophys.29.1.577  0.807
2000 Weintraub BC, Jun JE, Bishop AC, Shokat KM, Thomas ML, Goodnow CC. Entry of B cell receptor into signaling domains is inhibited in tolerant B cells. The Journal of Experimental Medicine. 191: 1443-8. PMID 10770810 DOI: 10.1084/Jem.191.8.1443  0.733
2000 Armstrong JI, Portley AR, Chang YT, Nierengarten DM, Cook BN, Bowman KG, Bishop A, Gray NS, Shokat KM, Schultz PG, Bertozzi CR. Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library We thank Sharon Long and Dave Keating for providing both the NodH sulfotransferase and APS Kinase during our preliminary experiments and Jack Kirsch for numerous helpful conversations. J.I.A. and K.G.B were supported by NIH Molecular Biophysics Training Grant (No. T32GM0895). This research was funded by grants to C.R.B. from the Pew Scholars Program, the W. M. Keck Foundation and the American Cancer Society (Grant No. RPG9700501BE). Angewandte Chemie (International Ed. in English). 39: 1303-1306. PMID 10767039 DOI: 10.1002/(Sici)1521-3773(20000403)39:7<1303::Aid-Anie1303>3.0.Co;2-0  0.767
2000 Taylorl V, Wong M, Olsen S, Felcher J, Shah K, Shokat K, Stokoe D. IDENTIFICATION OF NOVEL SUBSTRATES AND A PROTEIN INHIBITOR OF PHOSPHOINOSITIDE-DEPENDENT KINASE-1 Biochemical Society Transactions. 28: A283-A283. DOI: 10.1042/Bst028A283B  0.519
2000 Ulrich SM, Buzko O, Shah K, Shokat KM. Towards the Engineering of an Orthogonal Protein Kinase/Nucleotide Triphosphate Pair Tetrahedron. 56: 9495-9502. DOI: 10.1016/S0040-4020(00)00834-6  0.848
1999 Gillespie PG, Gillespie SK, Mercer JA, Shah K, Shokat KM. Engineering of the myosin-ibeta nucleotide-binding pocket to create selective sensitivity to N(6)-modified ADP analogs. The Journal of Biological Chemistry. 274: 31373-81. PMID 10531338 DOI: 10.1074/Jbc.274.44.31373  0.481
1999 Buzko OV, Shokat KM. Blocking HIV entry. Nature Structural Biology. 6: 906-8. PMID 10504719 DOI: 10.1038/13266  0.759
1999 Liu Y, Bishop A, Witucki L, Kraybill B, Shimizu E, Tsien J, Ubersax J, Blethrow J, Morgan DO, Shokat KM. Structural basis for selective inhibition of Src family kinases by PP1. Chemistry & Biology. 6: 671-8. PMID 10467133 DOI: 10.1016/S1074-5521(99)80118-5  0.845
1999 Bishop AC, Shokat KM. Acquisition of inhibitor-sensitive protein kinases through protein design. Pharmacology & Therapeutics. 82: 337-46. PMID 10454210 DOI: 10.1016/S0163-7258(98)00060-6  0.759
1999 Yang F, Liu Y, Bixby SD, Friedman JD, Shokat KM. Highly efficient green fluorescent protein-based kinase substrates. Analytical Biochemistry. 266: 167-73. PMID 9888972 DOI: 10.1006/Abio.1998.2885  0.555
1999 Bishop AC, Kung CY, Shah K, Witucki L, Shokat KM, Liu Y. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach Journal of the American Chemical Society. 121: 627-631. DOI: 10.1021/Ja983267V  0.861
1998 Liu Y, Shah K, Yang F, Witucki L, Shokat KM. A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src. Bioorganic & Medicinal Chemistry. 6: 1219-26. PMID 9784863 DOI: 10.1016/S0968-0896(98)00099-6  0.813
1998 Surrey T, Elowitz MB, Wolf PE, Yang F, Nédélec F, Shokat K, Leibler S. Chromophore-assisted light inactivation and self-organization of microtubules and motors. Proceedings of the National Academy of Sciences of the United States of America. 95: 4293-8. PMID 9539730 DOI: 10.1073/Pnas.95.8.4293  0.389
1998 Bishop AC, Shah K, Liu Y, Witucki L, Kung C, Shokat KM. Design of allele-specific inhibitors to probe protein kinase signaling. Current Biology : Cb. 8: 257-66. PMID 9501066 DOI: 10.1016/S0960-9822(98)70198-8  0.85
1998 Liu Y, Shah K, Yang F, Witucki L, Shokat KM. Engineering Src family protein kinases with unnatural nucleotide specificity. Chemistry & Biology. 5: 91-101. PMID 9495830 DOI: 10.1016/S1074-5521(98)90143-0  0.842
1998 Bishop AC, Moore D, Scanlan TS, Shokat KM. Corrigendum to “Screening a hydroxystilbene library for selective inhibition of the B cell antigen receptor kinase cascade” [Tetrahedron 53 (1997) 11995] Tetrahedron. 54: 1953. DOI: 10.1016/S0040-4020(97)10425-2  0.755
1997 Shah K, Liu Y, Deirmengian C, Shokat KM. Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proceedings of the National Academy of Sciences of the United States of America. 94: 3565-70. PMID 9108016 DOI: 10.1073/Pnas.94.8.3565  0.666
1997 Bishop AC, Moore D, Scanlan TS, Shokat KM. Screening a hydroxystilbene library for selective inhibition of the B cell antigen receptor kinase cascade Tetrahedron. 53: 11995-12004. DOI: 10.1016/S0040-4020(97)00712-6  0.797
1996 Liblau RS, Tisch R, Shokat K, Yang XD, Dumont N, Goodnow CC, Mcdevitt HO. Intravenous injection of soluble antigen induces thymic and peripheral T-cell apoptosis Proceedings of the National Academy of Sciences of the United States of America. 93: 3031-3036. PMID 8610163 DOI: 10.1073/Pnas.93.7.3031  0.483
1995 Shokat KM. Tyrosine kinases: modular signaling enzymes with tunable specificities. Chemistry & Biology. 2: 509-14. PMID 9383454 DOI: 10.1016/1074-5521(95)90183-3  0.452
1995 Shokat KM, Goodnow CC. Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature. 375: 334-8. PMID 7753200 DOI: 10.1038/375334A0  0.488
1994 Cooke MP, Heath AW, Shokat KM, Zeng Y, Finkelman FD, Linsley PS, Howard M, Goodnow CC. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. The Journal of Experimental Medicine. 179: 425-38. PMID 8294858 DOI: 10.1084/Jem.179.2.425  0.518
1994 Shokat K, Uno T, Schultz PG. Mechanistic Studies of an Antibody-Catalyzed Elimination Reaction Journal of the American Chemical Society. 116: 2261-2270. DOI: 10.1021/Ja00085A004  0.408
1991 Shokat KM, Schultz PG. The generation of antibody combining sites containing catalytic residues. Ciba Foundation Symposium. 159: 118-28; discussion 1. PMID 1959444 DOI: 10.1002/9780470514108.ch9  0.338
1991 Shokat KM, Schultz PG. Catalytic antibodies. Methods in Enzymology. 203: 327-51. PMID 1762563 DOI: 10.1016/0076-6879(91)03019-D  0.415
1991 Shokat KM, Schultz PG. Redirecting the immune response: ligand-mediated immunogenicity Journal of the American Chemical Society. 113: 1861-1862. DOI: 10.1021/Ja00005A077  0.389
1990 Shokat KM, Ko MK, Scanlan TS, Kochersperger L, Yonkovich S, Thaisrivongs S, Schultz PG. Catalytic Antibodies: A New Class of Transition-State Analogues Used to Elicit Hydrolytic Antibodies Angewandte Chemie International Edition in English. 29: 1296-1303. DOI: 10.1002/Anie.199012961  0.604
1990 Shokat KM, Ko MK, Scanlan TS, Kochersperger L, Yonkovich S, Thaisrivongs S, Schultz PG. Katalytische Antikörper: Eine neue Klasse von Übergangszustands-Analoga zur Erzeugung hydrolytischer Antikörper Angewandte Chemie. 102: 1339-1346. DOI: 10.1002/Ange.19901021116  0.565
1989 Shokat KM, Leumann CJ, Sugasawara R, Schultz PG. A new strategy for the generation of catalytic antibodies. Nature. 338: 269-71. PMID 2922053 DOI: 10.1038/338269A0  0.595
1988 Shokat KM, Leumann CJ, Sugasawara R, Schultz PG. An Antibody-Mediated Redox Reaction Angewandte Chemie International Edition in English. 27: 1172-1174. DOI: 10.1002/Anie.198811721  0.565
1988 Shokat KM, Leumann CH, Sugasawara R, Schultz PG. Eine über Antikörper gesteuerte Redoxreaktion Angewandte Chemie. 100: 1227-1229. DOI: 10.1002/Ange.19881000925  0.385
1987 McClard RW, Shokat KM. Does the bifunctional uridylate synthase channel orotidine 5'-phosphate? Kinetics of orotate phosphoribosyltransferase and orotidylate decarboxylase activities fit a noninteracting sites model. Biochemistry. 26: 3378-84. PMID 3651388 DOI: 10.1021/Bi00386A020  0.696
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