| Year |
Citation |
Score |
| 2023 |
Gorski PA, Lee A, Lee P, Oh JG, Vangheluwe P, Ishikawa K, Hajjar R, Kho C. Identification and Characterization of p300-Mediated Lysine Residues in Cardiac SERCA2a. International Journal of Molecular Sciences. 24. PMID 36834924 DOI: 10.3390/ijms24043502 |
0.348 |
|
| 2023 |
Kumar M, Haghighi K, Koch S, Rubinstein J, Stillitano F, Hajjar RJ, Kranias EG, Sadayappan S. Myofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy. International Journal of Molecular Sciences. 24. PMID 36768995 DOI: 10.3390/ijms24032675 |
0.366 |
|
| 2022 |
Rogalska ME, Vafiadaki E, Erpapazoglou Z, Haghighi K, Green L, Mantzoros CS, Hajjar RJ, Tranter M, Karakikes I, Kranias EG, Stillitano F, Kafasla P, Sanoudou D. Isoform changes of action potential regulators in the ventricles of arrhythmogenic phospholamban-R14del humanized mouse hearts. Metabolism: Clinical and Experimental. 155344. PMID 36375644 DOI: 10.1016/j.metabol.2022.155344 |
0.414 |
|
| 2022 |
Main A, Boguslavskyi A, Howie J, Kuo CW, Rankin A, Burton FL, Smith GL, Hajjar R, Baillie GS, Campbell KS, Shattock MJ, Fuller W. Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies. Frontiers in Physiology. 13: 1023237. PMID 36277202 DOI: 10.3389/fphys.2022.1023237 |
0.364 |
|
| 2022 |
Dave J, Raad N, Mittal N, Zhang L, Fargnoli A, Oh JG, Savoia ME, Hansen J, Fava M, Yin X, Theofilatos K, Ceholski D, Kohlbrenner E, Jeong D, Wills L, ... ... Hajjar RJ, et al. Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modeling a European cardiomyopathy with global impact. Cardiovascular Research. PMID 35191471 DOI: 10.1093/cvr/cvac021 |
0.301 |
|
| 2021 |
Kaur K, Hadas Y, Kurian AA, Żak MM, Yoo J, Mahmood A, Girard H, Komargodski R, Io T, Santini MP, Sultana N, Kabir Sharkar MT, Magadum A, Fargnoli A, Yoon S, ... ... Hajjar RJ, et al. Direct Reprogramming Induces Vascular Regeneration Post Muscle Ischemic Injury. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 34332145 DOI: 10.1016/j.ymthe.2021.07.014 |
0.659 |
|
| 2021 |
Magadum A, Singh N, Kurian AA, Sharkar MTK, Sultana N, Chepurko E, Kaur K, Żak MM, Hadas Y, Lebeche D, Sahoo S, Hajjar R, Zangi L. Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 8: 2004661. PMID 34026458 DOI: 10.1002/advs.202004661 |
0.676 |
|
| 2020 |
Wong AO, Gurung B, Wong WS, Mak SY, Tse WW, Li CM, Lieu DK, Costa KD, Li RA, Hajjar RJ. Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues. Journal of Molecular and Cellular Cardiology. PMID 33373642 DOI: 10.1016/j.yjmcc.2020.12.014 |
0.327 |
|
| 2020 |
Lee MA, Raad N, Song MH, Yoo J, Lee M, Jang SP, Kwak TH, Kook H, Choi EK, Cha TJ, Hajjar RJ, Jeong D, Park WJ. The matricellular protein CCN5 prevents adverse atrial structural and electrical remodelling. Journal of Cellular and Molecular Medicine. PMID 32885578 DOI: 10.1111/jcmm.15789 |
0.335 |
|
| 2020 |
Magadum A, Singh N, Kurian AA, Munir I, Mehmood T, Brown K, Sharkar MTK, Chepurko E, Sassi Y, Oh JG, Lee P, Santos CXC, Gaziel-Sovran A, Zhang G, Cai CL, ... ... Hajjar RJ, et al. Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration. Circulation. PMID 32078387 DOI: 10.1161/CIRCULATIONAHA.119.043067 |
0.311 |
|
| 2020 |
Hadas Y, Vincek AS, Youssef E, Żak MM, Chepurko E, Sultana N, Sharkar MTK, Guo N, Komargodski R, Kurian AA, Kaur K, Magadum A, Fargnoli A, Katz MG, Hossain N, ... ... Hajjar R, et al. Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response after Myocardial Infarction. Circulation. PMID 31992066 DOI: 10.1161/Circulationaha.119.041882 |
0.312 |
|
| 2020 |
Mougenot N, Mika D, Czibik G, Marcos E, Abid S, Houssaini A, Vallin B, Guellich A, Mehel H, Sawaki D, Vandecasteele G, Fischmeister R, Hajjar RJ, Dubois-Randé JL, Limon I, et al. Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction. Cardiovascular Research. 115: 1778-1790. PMID 30605506 DOI: 10.1093/cvr/cvy306 |
0.313 |
|
| 2019 |
Chow MZ, Sadrian SN, Keung W, Geng L, Ren L, Kong CW, Wong AO, Hulot JS, Chen CS, Costa KD, Hajjar RJ, Li RA. Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues. Scientific Reports. 9: 7502. PMID 31097748 DOI: 10.1038/S41598-019-42953-W |
0.307 |
|
| 2019 |
Chen J, Strauss B, Liang L, Hajjar RJ. Animal model of left atrial thrombus in congestive heart failure in rats. American Journal of Physiology. Heart and Circulatory Physiology. PMID 31074653 DOI: 10.1152/ajpheart.00086.2019 |
0.317 |
|
| 2019 |
LaRocca TJ, Altman P, Jarrah AA, Gordon R, Wang E, Hadri L, Burke MW, Haddad GE, Hajjar RJ, Tarzami ST. CXCR4 Cardiac Specific Knockout Mice Develop a Progressive Cardiomyopathy. International Journal of Molecular Sciences. 20. PMID 31071921 DOI: 10.3390/Ijms20092267 |
0.411 |
|
| 2019 |
Santos-Gallego CG, Requena-Ibanez JA, San Antonio R, Ishikawa K, Watanabe S, Picatoste B, Flores E, Garcia-Ropero A, Sanz J, Hajjar RJ, Fuster V, Badimon JJ. Empagliflozin Ameliorates Adverse Left Ventricular Remodeling in Nondiabetic Heart Failure by Enhancing Myocardial Energetics. Journal of the American College of Cardiology. 73: 1931-1944. PMID 30999996 DOI: 10.1016/j.jacc.2019.01.056 |
0.316 |
|
| 2019 |
Gorski PA, Jang SP, Jeong D, Lee A, Lee P, Oh JG, Chepurko V, Yang DK, Kwak TH, Eom SH, Park ZY, Yoo YJ, Kim DH, Kook H, Sunagawa Y, ... ... Hajjar RJ, et al. Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca-ATPase in Heart Failure. Circulation Research. PMID 30786847 DOI: 10.1161/CIRCRESAHA.118.313865 |
0.329 |
|
| 2019 |
Oh JG, Jang SP, Yoo J, Lee MA, Lee SH, Lim T, Jeong E, Kho C, Kook H, Hajjar RJ, Park WJ, Jeong D. Role of the PRC2-Six1-miR-25 signaling axis in heart failure. Journal of Molecular and Cellular Cardiology. PMID 30771307 DOI: 10.1016/j.yjmcc.2019.01.017 |
0.317 |
|
| 2019 |
Chaanine AH, Joyce LD, Stulak JM, Maltais S, Joyce DL, Dearani JA, Klaus K, Nair KS, Hajjar RJ, Redfield MM. Mitochondrial Morphology, Dynamics, and Function in Human Pressure Overload or Ischemic Heart Disease With Preserved or Reduced Ejection Fraction. Circulation. Heart Failure. 12: e005131. PMID 30744415 DOI: 10.1161/Circheartfailure.118.005131 |
0.317 |
|
| 2018 |
Oh JG, Watanabe S, Lee A, Gorski PA, Lee P, Jeong D, Liang L, Liang Y, Baccarini A, Sahoo S, Brown BD, Hajjar RJ, Kho C. miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy. Circulation Research. 123: 673-685. PMID 30355233 DOI: 10.1161/CIRCRESAHA.118.312751 |
0.379 |
|
| 2018 |
Singh R, Moreno P, Hajjar RJ, Lebeche D. A role for calcium in resistin transcriptional activation in diabetic hearts. Scientific Reports. 8: 15633. PMID 30353146 DOI: 10.1038/s41598-018-34112-4 |
0.675 |
|
| 2018 |
Katz MG, Fargnoli AS, Yarnall C, Perez A, Isidro A, Hajjar RJ, Bridges CR. Technique of Complete Heart Isolation with Continuous Cardiac Perfusion During Cardiopulmonary Bypass: New Opportunities for Gene Therapy. The Journal of Extra-Corporeal Technology. 50: 193-198. PMID 30250349 |
0.319 |
|
| 2018 |
Mathiyalagan P, Adamiak M, Mayourian J, Sassi Y, Liang Y, Agarwal N, Jha D, Zhang S, Kohlbrenner E, Chepurko E, Chen J, Trivieri MG, Singh R, Bouchareb R, Fish K, ... ... Hajjar RJ, et al. FTO-Dependent m6A Regulates Cardiac Function During Remodeling and Repair. Circulation. PMID 29997116 DOI: 10.1161/CIRCULATIONAHA.118.033794 |
0.717 |
|
| 2018 |
Watanabe S, Bikou O, Hajjar RJ, Ishikawa K. Swine Model of Mitral Regurgitation Induced Heart Failure. Methods in Molecular Biology (Clifton, N.J.). 1816: 327-335. PMID 29987831 DOI: 10.1007/978-1-4939-8597-5_25 |
0.327 |
|
| 2018 |
Bikou O, Watanabe S, Hajjar RJ, Ishikawa K. A Pig Model of Myocardial Infarction: Catheter-Based Approaches. Methods in Molecular Biology (Clifton, N.J.). 1816: 281-294. PMID 29987828 DOI: 10.1007/978-1-4939-8597-5_22 |
0.318 |
|
| 2018 |
Yoo J, Chepurko V, Hajjar RJ, Jeong D. Conventional Method of Transverse Aortic Constriction in Mice. Methods in Molecular Biology (Clifton, N.J.). 1816: 183-193. PMID 29987820 DOI: 10.1007/978-1-4939-8597-5_14 |
0.34 |
|
| 2018 |
Asensio-Lopez MDC, Lax Perez A, Fernandez Del Palacio MJ, Sassi Y, Hajjar RJ, Pascual-Figal DA. Pharmacological inhibition of the mitochondrial NADPH oxidase 4/PKCα/Gal-3 pathway reduces left ventricular fibrosis following myocardial infarction. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 29753686 DOI: 10.1016/j.trsl.2018.04.004 |
0.375 |
|
| 2018 |
Gordon HP, Katz MG, Fargnoli AS, Gillespie VL, Hajjar RJ, Bridges CR. Scar Size and Other Parameters for Tracking Left Ventricular Dysfunction after Induction of Myocardial Infarcts in Sheep (Ovis aries). Comparative Medicine. PMID 29747722 DOI: 10.30802/Aalas-Cm-17-000040 |
0.353 |
|
| 2018 |
Rodriguez P, Sassi Y, Troncone L, Benard L, Ishikawa K, Gordon RE, Lamas S, Laborda J, Hajjar RJ, Lebeche D. Deletion of delta-like 1 homologue accelerates fibroblast-myofibroblast differentiation and induces myocardial fibrosis. European Heart Journal. PMID 29668883 DOI: 10.1093/eurheartj/ehy188 |
0.681 |
|
| 2018 |
Chamberlain K, Riyad JM, Garnett T, Kohlbrenner E, Mookerjee A, Elmastour F, Benard L, Chen J, VandenDriessche T, Chuah MKL, Marian AJ, Hajjar R, Gurha P, Weber T. A calsequestrin cis-regulatory motif coupled to a cardiac troponin T promoter improves cardiac AAV9 transduction specificity. Human Gene Therapy. PMID 29641321 DOI: 10.1089/hum.2017.188 |
0.333 |
|
| 2018 |
Watanabe S, Fish K, Kovacic JC, Bikou O, Leonardson L, Nomoto K, Aguero J, Kapur NK, Hajjar RJ, Ishikawa K. Left Ventricular Unloading Using an Impella CP Improves Coronary Flow and Infarct Zone Perfusion in Ischemic Heart Failure. Journal of the American Heart Association. 7. PMID 29514806 DOI: 10.1161/JAHA.117.006462 |
0.315 |
|
| 2018 |
Kawai H, Chaudhry F, Shekhar A, Petrov A, Nakahara T, Tanimoto T, Kim D, Chen J, Lebeche D, Blankenberg FG, Pak KY, Kolodgie FD, Virmani R, Sengupta P, Narula N, ... Hajjar RJ, et al. Molecular Imaging of Apoptosis in Ischemia Reperfusion Injury With Radiolabeled Duramycin Targeting Phosphatidylethanolamine: Effective Target Uptake and Reduced Nontarget Organ Radiation Burden. Jacc. Cardiovascular Imaging. PMID 29454770 DOI: 10.1016/j.jcmg.2017.11.037 |
0.577 |
|
| 2018 |
Mayourian J, Ceholski DK, Gonzalez DM, Cashman TJ, Sahoo S, Hajjar RJ, Costa KD. Physiologic, Pathologic, and Therapeutic Paracrine Modulation of Cardiac Excitation-Contraction Coupling. Circulation Research. 122: 167-183. PMID 29301848 DOI: 10.1161/Circresaha.117.311589 |
0.347 |
|
| 2018 |
Jarrah AA, Schwarskopf M, Wang ER, LaRocca T, Dhume A, Zhang S, Hadri L, Hajjar RJ, Schecter AD, Tarzami ST. SDF-1 induces TNF-mediated apoptosis in cardiac myocytes. Apoptosis : An International Journal On Programmed Cell Death. 23: 79-91. PMID 29236198 DOI: 10.1007/S10495-017-1438-3 |
0.301 |
|
| 2018 |
Hajjar RJ, Ishikawa K. Introducing Genes to the Heart: All About Delivery. Circulation Research. 120: 33-35. PMID 28057788 DOI: 10.1161/CIRCRESAHA.116.310039 |
0.304 |
|
| 2017 |
Katz MG, Fargnoli AS, Hajjar RJ, Bridges CR. Heart Isolation Featuring Closed Loop Recirculation: The Gold Standard for Optimum Cardiac Gene Transfer? Advanced Techniques in Biology & Medicine. 5. PMID 29682631 DOI: 10.4172/2379-1764.1000241 |
0.347 |
|
| 2017 |
Bidwell PA, Liu GS, Nagarajan N, Lam CK, Haghighi K, Gardner G, Cai WF, Zhao W, Mugge L, Vafiadaki E, Sanoudou D, Rubinstein J, Lebeche D, Hajjar R, Sadoshima J, et al. HAX-1 regulates SERCA2a oxidation and degradation. Journal of Molecular and Cellular Cardiology. PMID 29169992 DOI: 10.1016/J.Yjmcc.2017.11.014 |
0.666 |
|
| 2017 |
Watanabe S, Ishikawa K, Fish K, Oh JG, Motloch LJ, Kohlbrenner E, Lee P, Xie C, Lee A, Liang L, Kho C, Leonardson L, McIntyre M, Wilson S, Samulski RJ, ... ... Hajjar RJ, et al. Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure. Journal of the American College of Cardiology. 70: 1744-1756. PMID 28958332 DOI: 10.1016/J.Jacc.2017.08.013 |
0.369 |
|
| 2017 |
Motloch LJ, Ishikawa K, Xie C, Hu J, Aguero J, Fish KM, Hajjar RJ, Akar FG. Increased afterload following myocardial infarction promotes conduction-dependent arrhythmias that are unmasked by hypokalemia. Jacc. Basic to Translational Science. 2: 258-269. PMID 28798965 DOI: 10.1016/j.jacbts.2017.02.002 |
0.32 |
|
| 2017 |
Katz MG, Fargnoli AS, Weber T, Hajjar R, Bridges C. Use of Adeno-Associated Virus Vector for Cardiac Gene Delivery in Large Animal Surgical Models of Heart Failure. Human Gene Therapy. Clinical Development. PMID 28726495 DOI: 10.1089/Humc.2017.070 |
0.334 |
|
| 2017 |
Hammoudi N, Jeong D, Singh R, Farhat A, Komajda M, Mayoux E, Hajjar R, Lebeche D. Empagliflozin Improves Left Ventricular Diastolic Dysfunction in a Genetic Model of Type 2 Diabetes. Cardiovascular Drugs and Therapy. PMID 28643218 DOI: 10.1007/s10557-017-6734-1 |
0.665 |
|
| 2017 |
Mayourian J, Cashman TJ, Ceholski DK, Johnson BV, Sachs D, Kaji DA, Sahoo S, Hare JM, Hajjar RJ, Sobie EA, Costa KD. Experimental and Computational Insight into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity. Circulation Research. PMID 28642329 DOI: 10.1161/Circresaha.117.310796 |
0.313 |
|
| 2017 |
Hulot JS, Salem JE, Redheuil A, Collet JP, Varnous S, Jourdain P, Logeart D, Gandjbakhch E, Bernard C, Hatem SN, Isnard R, Cluzel P, Le Feuvre C, Leprince P, Hammoudi N, ... ... Hajjar RJ, et al. Effect of intracoronary administration of AAV1/SERCA2a on ventricular remodelling in patients with advanced systolic heart failure: results from the AGENT-HF randomized phase 2 trial. European Journal of Heart Failure. PMID 28393439 DOI: 10.1002/ejhf.826 |
0.378 |
|
| 2017 |
Sultana N, Magadum A, Hadas Y, Kondrat J, Singh N, Youssef E, Calderon D, Chepurko E, Dubois N, Hajjar RJ, Zangi L. Optimizing Cardiac Delivery of Modified mRNA. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28389322 DOI: 10.1016/j.ymthe.2017.03.016 |
0.358 |
|
| 2017 |
Lebeche D, Hajjar R. Candesartan abrogates G protein-coupled receptors agonist-induced MAPK activation and cardiac myocyte hypertrophy. Journal of the Renin-Angiotensin-Aldosterone System : Jraas. 2: S154-S161. PMID 28095237 DOI: 10.1177/14703203010020012701 |
0.628 |
|
| 2016 |
Chen J, Hammoudi N, Benard L, Ceholski DK, Zhang S, Lebeche D, Hajjar RJ. The Probability of Inconstancy in Assessment of Cardiac Function Post-Myocardial Infarction in Mice. Cardiovascular Pharmacology: Open Access. 5. PMID 27917392 |
0.658 |
|
| 2016 |
Chaanine AH, Kohlbrenner E, Gamb SI, Guenzel AJ, Klaus KA, Fayyaz AU, Nair KS, Hajjar RJ, Redfield MM. FOXO3a Regulates BNIP3 and Modulates Mitochondrial Calcium, Dynamics and Function in Cardiac Stress. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00549.2016. PMID 27694219 DOI: 10.1152/Ajpheart.00549.2016 |
0.313 |
|
| 2016 |
Yan J, Zhang L, Sultana N, Oh JG, Wu B, Hajjar RJ, Zhou B, Cai CL. A series of robust genetic indicators for definitive identification of cardiomyocytes. Journal of Molecular and Cellular Cardiology. PMID 27266388 DOI: 10.1016/j.yjmcc.2016.06.003 |
0.372 |
|
| 2016 |
Jeong D, Lee MA, Li Y, Yang DK, Kho C, Oh JG, Hong G, Lee A, Song MH, LaRocca TJ, Chen J, Liang L, Mitsuyama S, D'Escamard V, Kovacic JC, ... ... Hajjar RJ, et al. Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis. Journal of the American College of Cardiology. 67: 1556-68. PMID 27150688 DOI: 10.1016/J.Jacc.2016.01.030 |
0.368 |
|
| 2016 |
Bénard L, Oh JG, Cacheux M, Lee A, Nonnenmacher M, Matasic DS, Kohlbrenner E, Kho C, Pavoine C, Hajjar RJ, Hulot JS. Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling. Circulation. PMID 26936863 DOI: 10.1161/CIRCULATIONAHA.115.020678 |
0.344 |
|
| 2015 |
Lee A, Oh JG, Gorski PA, Hajjar RJ, Kho C. Post-translational Modifications in Heart Failure: Small Changes, Big Impact. Heart, Lung & Circulation. PMID 26795636 DOI: 10.1016/j.hlc.2015.11.008 |
0.335 |
|
| 2015 |
Katz MG, Brandon-Warner E, Fargnoli AS, Williams RD, Kendle AP, Hajjar RJ, Schrum LW, Bridges CR. Mitigation of myocardial fibrosis by molecular cardiac surgery-mediated gene overexpression. The Journal of Thoracic and Cardiovascular Surgery. PMID 26769537 DOI: 10.1016/J.Jtcvs.2015.11.031 |
0.38 |
|
| 2015 |
Katz MG, Fargnoli AS, Kendle AP, Hajjar RJ, Bridges CR. The Role of microRNAs in Cardiac Development and Regenerative Capacity. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00181.2015. PMID 26702142 DOI: 10.1152/Ajpheart.00181.2015 |
0.33 |
|
| 2015 |
Kang S, Dahl R, Hsieh W, Shin AC, Zsebo KM, Buettner C, Hajjar RJ, Lebeche D. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders. The Journal of Biological Chemistry. PMID 26702054 DOI: 10.1074/Jbc.M115.705012 |
0.618 |
|
| 2015 |
Sultana N, Zhang L, Yan J, Chen J, Cai W, Razzaque S, Jeong D, Sheng W, Bu L, Xu M, Huang GY, Hajjar RJ, Zhou B, Moon A, Cai CL. Resident c-kit(+) cells in the heart are not cardiac stem cells. Nature Communications. 6: 8701. PMID 26515110 DOI: 10.1038/ncomms9701 |
0.334 |
|
| 2015 |
Turnbull IC, Eltoukhy AA, Fish KM, Nonnenmacher M, Ishikawa K, Chen J, Hajjar RJ, Anderson DG, Costa KD. Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26471463 DOI: 10.1038/Mt.2015.193 |
0.318 |
|
| 2015 |
Haghighi K, Pritchard TJ, Liu GS, Singh VP, Bidwell P, Lam CK, Vafiadaki E, Das P, Ma J, Kunduri S, Sanoudou D, Florea S, Vanderbilt E, Wang HS, Rubinstein J, ... Hajjar RJ, et al. Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias. Journal of Molecular and Cellular Cardiology. PMID 26455482 DOI: 10.1016/J.Yjmcc.2015.10.004 |
0.354 |
|
| 2015 |
Ramos-Kuri M, Rapti K, Mehel H, Zhang S, Dhandapany PS, Liang L, García-Carrancá A, Bobe R, Fischmeister R, Adnot S, Lebeche D, Hajjar RJ, Lipskaia L, Chemaly ER. Dominant negative Ras attenuates pathological ventricular remodeling in pressure overload cardiac hypertrophy. Biochimica Et Biophysica Acta. PMID 26260012 DOI: 10.1016/j.bbamcr.2015.08.006 |
0.605 |
|
| 2015 |
Cai WF, Liu GS, Lam CK, Florea S, Qian J, Zhao W, Pritchard T, Haghighi K, Lebeche D, Lu LJ, Deng J, Fan GC, Hajjar RJ, Kranias EG. Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility. European Journal of Heart Failure. 17: 782-93. PMID 26177627 DOI: 10.1002/Ejhf.323 |
0.657 |
|
| 2015 |
Chaanine AH, Gordon RE, Nonnenmacher M, Kohlbrenner E, Benard L, Hajjar RJ. High-dose chloroquine is metabolically cardiotoxic by inducing lysosomes and mitochondria dysfunction in a rat model of pressure overload hypertrophy. Physiological Reports. 3. PMID 26152691 DOI: 10.14814/phy2.12413 |
0.301 |
|
| 2015 |
Kho C, Lee A, Jeong D, Oh JG, Gorski PA, Fish K, Sanchez R, DeVita RJ, Christensen G, Dahl R, Hajjar RJ. Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nature Communications. 6: 7229. PMID 26068603 DOI: 10.1038/Ncomms8229 |
0.382 |
|
| 2015 |
Ishikawa K, Aguero J, Tilemann L, Ladage D, Hammoudi N, Kawase Y, Santos-Gallego CG, Fish K, Levine RA, Hajjar RJ. Reply to "Letter to the editor: Characterizing preclinical model of ischemic heart failure: difference between LAD and LCx infarctions". American Journal of Physiology. Heart and Circulatory Physiology. 308: H365-6. PMID 25684739 DOI: 10.1152/Ajpheart.00855.2014 |
0.32 |
|
| 2015 |
Ishikawa K, Fish K, Aguero J, Yaniz-Galende E, Jeong D, Kho C, Tilemann L, Fish L, Liang L, Eltoukhy AA, Anderson DG, Zsebo K, Costa KD, Hajjar RJ. Stem cell factor gene transfer improves cardiac function after myocardial infarction in swine. Circulation. Heart Failure. 8: 167-74. PMID 25342737 DOI: 10.1161/Circheartfailure.114.001711 |
0.331 |
|
| 2014 |
Lipskaia L, Keuylian Z, Blirando K, Mougenot N, Jacquet A, Rouxel C, Sghairi H, Elaib Z, Blaise R, Adnot S, Hajjar RJ, Chemaly ER, Limon I, Bobe R. Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis. Biochimica Et Biophysica Acta. 1843: 2705-18. PMID 25110346 DOI: 10.1016/j.bbamcr.2014.08.002 |
0.305 |
|
| 2014 |
Ishikawa K, Fish KM, Tilemann L, Rapti K, Aguero J, Santos-Gallego CG, Lee A, Karakikes I, Xie C, Akar FG, Shimada YJ, Gwathmey JK, Asokan A, McPhee S, Samulski J, ... ... Hajjar RJ, et al. Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 2038-45. PMID 25023328 DOI: 10.1038/Mt.2014.127 |
0.377 |
|
| 2014 |
Lee A, Jeong D, Mitsuyama S, Oh JG, Liang L, Ikeda Y, Sadoshima J, Hajjar RJ, Kho C. The role of SUMO-1 in cardiac oxidative stress and hypertrophy. Antioxidants & Redox Signaling. 21: 1986-2001. PMID 24893265 DOI: 10.1089/ars.2014.5983 |
0.369 |
|
| 2014 |
Dhandapany PS, Razzaque MA, Muthusami U, Kunnoth S, Edwards JJ, Mulero-Navarro S, Riess I, Pardo S, Sheng J, Rani DS, Rani B, Govindaraj P, Flex E, Yokota T, Furutani M, ... ... Hajjar RJ, et al. RAF1 mutations in childhood-onset dilated cardiomyopathy. Nature Genetics. 46: 635-9. PMID 24777450 DOI: 10.1038/Ng.2963 |
0.623 |
|
| 2014 |
Wahlquist C, Jeong D, Rojas-Muñoz A, Kho C, Lee A, Mitsuyama S, van Mil A, Park WJ, Sluijter JP, Doevendans PA, Hajjar RJ, Mercola M. Inhibition of miR-25 improves cardiac contractility in the failing heart. Nature. 508: 531-5. PMID 24670661 DOI: 10.1038/Nature13073 |
0.334 |
|
| 2014 |
Greenberg B, Yaroshinsky A, Zsebo KM, Butler J, Felker GM, Voors AA, Rudy JJ, Wagner K, Hajjar RJ. Design of a phase 2b trial of intracoronary administration of AAV1/SERCA2a in patients with advanced heart failure: the CUPID 2 trial (calcium up-regulation by percutaneous administration of gene therapy in cardiac disease phase 2b). Jacc. Heart Failure. 2: 84-92. PMID 24622121 DOI: 10.1016/j.jchf.2013.09.008 |
0.319 |
|
| 2014 |
Chaanine AH, Nonnenmacher M, Kohlbrenner E, Jin D, Kovacic JC, Akar FG, Hajjar RJ, Weber T. Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure. Gene Therapy. 21: 379-86. PMID 24572786 DOI: 10.1038/gt.2014.7 |
0.348 |
|
| 2014 |
Akar FG, Hajjar RJ. Gene therapies for arrhythmias in heart failure. PflüGers Archiv : European Journal of Physiology. 466: 1211-7. PMID 24566976 DOI: 10.1007/s00424-014-1485-3 |
0.317 |
|
| 2014 |
Turnbull IC, Karakikes I, Serrao GW, Backeris P, Lee JJ, Xie C, Senyei G, Gordon RE, Li RA, Akar FG, Hajjar RJ, Hulot JS, Costa KD. Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 644-54. PMID 24174427 DOI: 10.1096/Fj.13-228007 |
0.32 |
|
| 2014 |
Yerevanian A, Yerevanian A, Hajjar RJ. Progress in gene therapy for heart failure. Journal of Cardiovascular Pharmacology. 63: 95-106. PMID 23921315 DOI: 10.1097/FJC.0b013e3182a2e8b8 |
0.342 |
|
| 2013 |
Pritchard TJ, Kawase Y, Haghighi K, Anjak A, Cai W, Jiang M, Nicolaou P, Pylar G, Karakikes I, Rapti K, Rubinstein J, Hajjar RJ, Kranias EG. Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts. Plos One. 8: e80717. PMID 24312496 DOI: 10.1371/Journal.Pone.0080717 |
0.407 |
|
| 2013 |
Tilemann L, Lee A, Ishikawa K, Aguero J, Rapti K, Santos-Gallego C, Kohlbrenner E, Fish KM, Kho C, Hajjar RJ. SUMO-1 gene transfer improves cardiac function in a large-animal model of heart failure. Science Translational Medicine. 5: 211ra159. PMID 24225946 DOI: 10.1126/scitranslmed.3006487 |
0.405 |
|
| 2013 |
Chemaly ER, Kang S, Zhang S, McCollum L, Chen J, Bénard L, Purushothaman KR, Hajjar RJ, Lebeche D. Differential patterns of replacement and reactive fibrosis in pressure and volume overload are related to the propensity for ischaemia and involve resistin. The Journal of Physiology. 591: 5337-55. PMID 24018949 DOI: 10.1113/jphysiol.2013.258731 |
0.645 |
|
| 2013 |
Fargnoli AS, Katz MG, Yarnall C, Isidro A, Petrov M, Steuerwald N, Ghosh S, Richardville KC, Hillesheim R, Williams RD, Kohlbrenner E, Stedman HH, Hajjar RJ, Bridges CR. Cardiac surgical delivery of the sarcoplasmic reticulum calcium ATPase rescues myocytes in ischemic heart failure. The Annals of Thoracic Surgery. 96: 586-95. PMID 23773730 DOI: 10.1016/J.Athoracsur.2013.04.021 |
0.385 |
|
| 2013 |
Karakikes I, Chaanine AH, Kang S, Mukete BN, Jeong D, Zhang S, Hajjar RJ, Lebeche D. Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling. Journal of the American Heart Association. 2: e000078. PMID 23612897 DOI: 10.1161/JAHA.113.000078 |
0.662 |
|
| 2013 |
Chaanine AH, Gordon RE, Kohlbrenner E, Benard L, Jeong D, Hajjar RJ. Potential role of BNIP3 in cardiac remodeling, myocardial stiffness, and endoplasmic reticulum: mitochondrial calcium homeostasis in diastolic and systolic heart failure. Circulation. Heart Failure. 6: 572-83. PMID 23508759 DOI: 10.1161/CIRCHEARTFAILURE.112.000200 |
0.372 |
|
| 2013 |
Chemaly ER, Hajjar RJ, Lipskaia L. Molecular targets of current and prospective heart failure therapies. Heart (British Cardiac Society). 99: 992-1003. PMID 23349349 DOI: 10.1136/heartjnl-2012-302970 |
0.3 |
|
| 2013 |
Naim C, Yerevanian A, Hajjar RJ. Gene therapy for heart failure: where do we stand? Current Cardiology Reports. 15: 333. PMID 23307169 DOI: 10.1007/s11886-012-0333-3 |
0.314 |
|
| 2013 |
Hajjar RJ. Potential of gene therapy as a treatment for heart failure. The Journal of Clinical Investigation. 123: 53-61. PMID 23281410 DOI: 10.1172/JCI62837 |
0.314 |
|
| 2013 |
Fish KM, Ladage D, Kawase Y, Karakikes I, Jeong D, Ly H, Ishikawa K, Hadri L, Tilemann L, Muller-Ehmsen J, Samulski RJ, Kranias EG, Hajjar RJ. AAV9.I-1c delivered via direct coronary infusion in a porcine model of heart failure improves contractility and mitigates adverse remodeling. Circulation. Heart Failure. 6: 310-7. PMID 23271792 DOI: 10.1161/Circheartfailure.112.971325 |
0.418 |
|
| 2013 |
Kratlian RG, Hajjar RJ. Cardiac gene therapy: from concept to reality. Current Heart Failure Reports. 9: 33-9. PMID 22143928 DOI: 10.1007/s11897-011-0077-1 |
0.324 |
|
| 2012 |
Balderman JA, Lee HY, Mahoney CE, Handy DE, White K, Annis S, Lebeche D, Hajjar RJ, Loscalzo J, Leopold JA. Bone morphogenetic protein-2 decreases microRNA-30b and microRNA-30c to promote vascular smooth muscle cell calcification. Journal of the American Heart Association. 1: e003905. PMID 23316327 DOI: 10.1161/Jaha.112.003905 |
0.578 |
|
| 2012 |
Kho C, Lee A, Hajjar RJ. Altered sarcoplasmic reticulum calcium cycling--targets for heart failure therapy. Nature Reviews. Cardiology. 9: 717-33. PMID 23090087 DOI: 10.1038/nrcardio.2012.145 |
0.303 |
|
| 2012 |
Cutler MJ, Wan X, Plummer BN, Liu H, Deschenes I, Laurita KR, Hajjar RJ, Rosenbaum DS. Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart. Circulation. 126: 2095-104. PMID 23019291 DOI: 10.1161/Circulationaha.111.071480 |
0.399 |
|
| 2012 |
Park CS, Cha H, Kwon EJ, Jeong D, Hajjar RJ, Kranias EG, Cho C, Park WJ, Kim DH. AAV-Mediated Knock-Down of HRC Exacerbates Transverse Aorta Constriction-Induced Heart Failure Plos One. 7. PMID 22952658 DOI: 10.1371/Journal.Pone.0043282 |
0.393 |
|
| 2012 |
Kranias EG, Hajjar RJ. Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome. Circulation Research. 110: 1646-60. PMID 22679139 DOI: 10.1161/Circresaha.111.259754 |
0.364 |
|
| 2012 |
Larocca TJ, Jeong D, Kohlbrenner E, Lee A, Chen J, Hajjar RJ, Tarzami ST. CXCR4 gene transfer prevents pressure overload induced heart failure. Journal of Molecular and Cellular Cardiology. 53: 223-32. PMID 22668785 DOI: 10.1016/J.Yjmcc.2012.05.016 |
0.438 |
|
| 2012 |
LaRocca TJ, Fabris F, Chen J, Benhayon D, Zhang S, McCollum L, Schecter AD, Cheung JY, Sobie EA, Hajjar RJ, Lebeche D. Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway. American Journal of Physiology. Heart and Circulatory Physiology. 303: H353-67. PMID 22610174 DOI: 10.1152/Ajpheart.01198.2011 |
0.716 |
|
| 2012 |
Kairouz V, Lipskaia L, Hajjar RJ, Chemaly ER. Molecular targets in heart failure gene therapy: current controversies and translational perspectives. Annals of the New York Academy of Sciences. 1254: 42-50. PMID 22548568 DOI: 10.1111/j.1749-6632.2012.06520.x |
0.302 |
|
| 2012 |
Sun N, Yazawa M, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S, Chen R, Hajjar RJ, Snyder MP, et al. Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Science Translational Medicine. 4: 130ra47. PMID 22517884 DOI: 10.1126/Scitranslmed.3003552 |
0.326 |
|
| 2012 |
Tilemann L, Ishikawa K, Weber T, Hajjar RJ. Gene therapy for heart failure. Circulation Research. 110: 777-93. PMID 22383712 DOI: 10.1161/CIRCRESAHA.111.252981 |
0.311 |
|
| 2012 |
Kumarswamy R, Lyon AR, Volkmann I, Mills AM, Bretthauer J, Pahuja A, Geers-Knörr C, Kraft T, Hajjar RJ, Macleod KT, Harding SE, Thum T. SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway. European Heart Journal. 33: 1067-75. PMID 22362515 DOI: 10.1093/Eurheartj/Ehs043 |
0.397 |
|
| 2012 |
Karakikes I, Hadri L, Rapti K, Ladage D, Ishikawa K, Tilemann L, Yi GH, Morel C, Gwathmey JK, Zsebo K, Weber T, Kawase Y, Hajjar RJ. Concomitant intravenous nitroglycerin with intracoronary delivery of AAV1.SERCA2a enhances gene transfer in porcine hearts Molecular Therapy. 20: 565-571. PMID 22215018 DOI: 10.1038/mt.2011.268 |
0.346 |
|
| 2012 |
Lee SH, Kim J, Ryu JY, Lee S, Yang DK, Jeong D, Kim J, Lee SH, Kim JM, Hajjar RJ, Park WJ. Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy. Journal of Molecular and Cellular Cardiology. 52: 718-26. PMID 22197309 DOI: 10.1016/j.yjmcc.2011.12.002 |
0.305 |
|
| 2011 |
Ladage D, Tilemann L, Ishikawa K, Correll RN, Kawase Y, Houser SR, Molkentin JD, Hajjar RJ. Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury. Circulation Research. 109: 1396-400. PMID 21998327 DOI: 10.1161/Circresaha.111.255687 |
0.411 |
|
| 2011 |
Kho C, Lee A, Jeong D, Oh JG, Chaanine AH, Kizana E, Park WJ, Hajjar RJ. SUMO1-dependent modulation of SERCA2a in heart failure. Nature. 477: 601-5. PMID 21900893 DOI: 10.1038/nature10407 |
0.443 |
|
| 2011 |
Shin JH, Bostick B, Yue Y, Hajjar R, Duan D. SERCA2a gene transfer improves electrocardiographic performance in aged mdx mice. Journal of Translational Medicine. 9: 132. PMID 21834967 DOI: 10.1186/1479-5876-9-132 |
0.322 |
|
| 2011 |
Chaanine AH, Hajjar RJ. AKT signalling in the failing heart. European Journal of Heart Failure. 13: 825-9. PMID 21724622 DOI: 10.1093/eurjhf/hfr080 |
0.321 |
|
| 2011 |
Jessup M, Greenberg B, Mancini D, Cappola T, Pauly DF, Jaski B, Yaroshinsky A, Zsebo KM, Dittrich H, Hajjar RJ. Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation. 124: 304-13. PMID 21709064 DOI: 10.1161/CIRCULATIONAHA.111.022889 |
0.306 |
|
| 2011 |
Chen J, Chemaly ER, Liang LF, LaRocca TJ, Yaniz-Galende E, Hajjar RJ. A new model of congestive heart failure in rats. American Journal of Physiology. Heart and Circulatory Physiology. 301: H994-1003. PMID 21685270 DOI: 10.1152/Ajpheart.00245.2011 |
0.363 |
|
| 2011 |
Ishikawa K, Ladage D, Tilemann L, Fish K, Kawase Y, Hajjar RJ. Gene transfer for ischemic heart failure in a preclinical model Journal of Visualized Experiments : Jove. PMID 21633324 DOI: 10.3791/2778 |
0.359 |
|
| 2011 |
Rapti K, Chaanine AH, Hajjar RJ. Targeted gene therapy for the treatment of heart failure. The Canadian Journal of Cardiology. 27: 265-83. PMID 21601767 DOI: 10.1016/j.cjca.2011.02.005 |
0.341 |
|
| 2011 |
Chemaly ER, Hadri L, Zhang S, Kim M, Kohlbrenner E, Sheng J, Liang L, Chen J, K-Raman P, Hajjar RJ, Lebeche D. Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats. Journal of Molecular and Cellular Cardiology. 51: 144-55. PMID 21549710 DOI: 10.1016/j.yjmcc.2011.04.006 |
0.628 |
|
| 2011 |
Kang S, Chemaly ER, Hajjar RJ, Lebeche D. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. The Journal of Biological Chemistry. 286: 18465-73. PMID 21478152 DOI: 10.1074/jbc.M110.200022 |
0.66 |
|
| 2011 |
Dhandapany PS, Fabris F, Tonk R, Illaste A, Karakikes I, Sorourian M, Sheng J, Hajjar RJ, Tartaglia M, Sobie EA, Lebeche D, Gelb BD. Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes. Journal of Molecular and Cellular Cardiology. 51: 4-15. PMID 21440552 DOI: 10.1016/J.Yjmcc.2011.03.001 |
0.663 |
|
| 2011 |
Lyon AR, Bannister ML, Collins T, Pearce E, Sepehripour AH, Dubb SS, Garcia E, O'Gara P, Liang L, Kohlbrenner E, Hajjar RJ, Peters NS, Poole-Wilson PA, Macleod KT, Harding SE. SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure. Circulation. Arrhythmia and Electrophysiology. 4: 362-72. PMID 21406682 DOI: 10.1161/Circep.110.961615 |
0.349 |
|
| 2011 |
Kawase Y, Ladage D, Hajjar RJ. Rescuing the failing heart by targeted gene transfer. Journal of the American College of Cardiology. 57: 1169-80. PMID 21371634 DOI: 10.1016/j.jacc.2010.11.023 |
0.316 |
|
| 2010 |
Gwathmey JK, Yerevanian AI, Hajjar RJ. Cardiac gene therapy with SERCA2a: from bench to bedside. Journal of Molecular and Cellular Cardiology. 50: 803-12. PMID 21093451 DOI: 10.1016/j.yjmcc.2010.11.011 |
0.345 |
|
| 2010 |
Njeim MT, Hajjar RJ. Gene therapy for heart failure. Archives of Cardiovascular Diseases. 103: 477-85. PMID 21074127 DOI: 10.1016/j.acvd.2010.04.004 |
0.326 |
|
| 2010 |
Peña JR, Szkudlarek AC, Warren CM, Heinrich LS, Gaffin RD, Jagatheesan G, del Monte F, Hajjar RJ, Goldspink PH, Solaro RJ, Wieczorek DF, Wolska BM. Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology. 49: 993-1002. PMID 20854827 DOI: 10.1016/J.Yjmcc.2010.09.010 |
0.35 |
|
| 2010 |
Chen G, Zhou X, Florea S, Qian J, Cai W, Zhang Z, Fan GC, Lorenz J, Hajjar RJ, Kranias EG. Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis. Basic Research in Cardiology. 105: 573-81. PMID 20512582 DOI: 10.1007/S00395-010-0106-3 |
0.305 |
|
| 2010 |
Hadri L, Bobe R, Kawase Y, Ladage D, Ishikawa K, Atassi F, Lebeche D, Kranias EG, Leopold JA, Lompré AM, Lipskaia L, Hajjar RJ. SERCA2a gene transfer enhances eNOS expression and activity in endothelial cells Molecular Therapy. 18: 1284-1292. PMID 20461063 DOI: 10.1038/Mt.2010.77 |
0.656 |
|
| 2010 |
Yoon PO, Lee MA, Cha H, Jeong MH, Kim J, Jang SP, Choi BY, Jeong D, Yang DK, Hajjar RJ, Park WJ. The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis. Journal of Molecular and Cellular Cardiology. 49: 294-303. PMID 20430035 DOI: 10.1016/j.yjmcc.2010.04.010 |
0.321 |
|
| 2010 |
Chen J, Chemaly E, Liang L, Kho C, Lee A, Park J, Altman P, Schecter AD, Hajjar RJ, Tarzami ST. Effects of CXCR4 gene transfer on cardiac function after ischemia-reperfusion injury. The American Journal of Pathology. 176: 1705-15. PMID 20133817 DOI: 10.2353/Ajpath.2010.090451 |
0.35 |
|
| 2010 |
Lipskaia L, Chemaly ER, Hadri L, Lompre AM, Hajjar RJ. Sarcoplasmic reticulum Ca(2+) ATPase as a therapeutic target for heart failure. Expert Opinion On Biological Therapy. 10: 29-41. PMID 20078230 DOI: 10.1517/14712590903321462 |
0.364 |
|
| 2010 |
Jin H, Hadri L, Palomeque J, Morel C, Karakikes I, Kaprielian R, Hajjar R, Lebeche D. KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular calcium signaling. Journal of Molecular and Cellular Cardiology. 48: 1169-79. PMID 20051248 DOI: 10.1016/J.Yjmcc.2009.12.019 |
0.717 |
|
| 2010 |
Jin H, Chemaly ER, Lee A, Kho C, Hadri L, Hajjar RJ, Akar FG. Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 451-63. PMID 19825979 DOI: 10.1096/fj.09-136622 |
0.32 |
|
| 2009 |
Cutler MJ, Wan X, Laurita KR, Hajjar RJ, Rosenbaum DS. Targeted SERCA2a gene expression identifies molecular mechanism and therapeutic target for arrhythmogenic cardiac alternans. Circulation. Arrhythmia and Electrophysiology. 2: 686-94. PMID 19948504 DOI: 10.1161/CIRCEP.109.863118 |
0.328 |
|
| 2009 |
Karakikes I, Kim M, Hadri L, Sakata S, Sun Y, Zhang W, Chemaly ER, Hajjar RJ, Lebeche D. Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a. Plos One. 4: e6474. PMID 19649297 DOI: 10.1371/Journal.Pone.0006474 |
0.673 |
|
| 2009 |
Nicolaou P, Hajjar RJ, Kranias EG. Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology. Journal of Molecular and Cellular Cardiology. 47: 365-71. PMID 19481088 DOI: 10.1016/J.Yjmcc.2009.05.010 |
0.374 |
|
| 2009 |
Nicolaou P, Rodriguez P, Ren X, Zhou X, Qian J, Sadayappan S, Mitton B, Pathak A, Robbins J, Hajjar RJ, Jones K, Kranias EG. Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. Circulation Research. 104: 1012-20. PMID 19299645 DOI: 10.1161/Circresaha.108.189811 |
0.378 |
|
| 2009 |
Lee SH, Yang DK, Choi BY, Lee YH, Kim SY, Jeong D, Hajjar RJ, Park WJ. The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling. Journal of Molecular and Cellular Cardiology. 46: 596-605. PMID 19272299 DOI: 10.1016/j.yjmcc.2008.12.021 |
0.402 |
|
| 2009 |
Suckau L, Fechner H, Chemaly E, Krohn S, Hadri L, Kockskämper J, Westermann D, Bisping E, Ly H, Wang X, Kawase Y, Chen J, Liang L, Sipo I, Vetter R, ... ... Hajjar RJ, et al. Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy. Circulation. 119: 1241-52. PMID 19237664 DOI: 10.1161/CIRCULATIONAHA.108.783852 |
0.683 |
|
| 2009 |
Haider N, Arbustini E, Gupta S, Liu H, Narula N, Hajjar R, Moorjani N, Westaby S, Semigran MJ, Dec GW, Chandrashekhar Y, Narula J. Concurrent upregulation of endogenous proapoptotic and antiapoptotic factors in failing human hearts. Nature Clinical Practice. Cardiovascular Medicine. 6: 250-61. PMID 19234503 DOI: 10.1038/Ncpcardio1452 |
0.349 |
|
| 2009 |
Takewa Y, Chemaly ER, Takaki M, Liang LF, Jin H, Karakikes I, Morel C, Taenaka Y, Tatsumi E, Hajjar RJ. Mechanical work and energetic analysis of eccentric cardiac remodeling in a volume overload heart failure in rats. American Journal of Physiology. Heart and Circulatory Physiology. 296: H1117-24. PMID 19201995 DOI: 10.1152/ajpheart.01120.2008 |
0.372 |
|
| 2008 |
Cha H, Kim JM, Oh JG, Jeong MH, Park CS, Park J, Jeong HJ, Park BK, Lee YH, Jeong D, Yang DK, Bernecker OY, Kim DH, Hajjar RJ, Park WJ. PICOT is a critical regulator of cardiac hypertrophy and cardiomyocyte contractility. Journal of Molecular and Cellular Cardiology. 45: 796-803. PMID 18929570 DOI: 10.1016/j.yjmcc.2008.09.124 |
0.365 |
|
| 2008 |
Lebeche D, Davidoff AJ, Hajjar RJ. Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy. Nature Clinical Practice. Cardiovascular Medicine. 5: 715-24. PMID 18813212 DOI: 10.1038/ncpcardio1347 |
0.655 |
|
| 2008 |
Refaat M, Chemaly E, Lebeche D, Gwathmey JK, Hajjar RJ. Ventricular arrhythmias after left ventricular assist device implantation. Pacing and Clinical Electrophysiology : Pace. 31: 1246-52. PMID 18811803 DOI: 10.1111/j.1540-8159.2008.01173.x |
0.662 |
|
| 2008 |
Kawase Y, Hajjar RJ. The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases. Nature Clinical Practice. Cardiovascular Medicine. 5: 554-65. PMID 18665137 DOI: 10.1038/ncpcardio1301 |
0.357 |
|
| 2008 |
Kim M, Oh JK, Sakata S, Liang I, Park W, Hajjar RJ, Lebeche D. Role of resistin in cardiac contractility and hypertrophy. Journal of Molecular and Cellular Cardiology. 45: 270-80. PMID 18597775 DOI: 10.1016/j.yjmcc.2008.05.006 |
0.717 |
|
| 2008 |
Misra P, Lebeche D, Ly H, Schwarzkopf M, Diaz G, Hajjar RJ, Schecter AD, Frangioni JV. Quantitation of CXCR4 expression in myocardial infarction using 99mTc-labeled SDF-1alpha. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 49: 963-9. PMID 18483105 DOI: 10.2967/Jnumed.107.050054 |
0.601 |
|
| 2008 |
Kawase Y, Ly HQ, Prunier F, Lebeche D, Shi Y, Jin H, Hadri L, Yoneyama R, Hoshino K, Takewa Y, Sakata S, Peluso R, Zsebo K, Gwathmey JK, Tardif JC, ... ... Hajjar RJ, et al. Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure. Journal of the American College of Cardiology. 51: 1112-9. PMID 18342232 DOI: 10.1016/J.Jacc.2007.12.014 |
0.693 |
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| 2008 |
Jeong D, Kim JM, Cha H, Oh JG, Park J, Yun SH, Ju ES, Jeon ES, Hajjar RJ, Park WJ. PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT signaling. Circulation Research. 102: 711-9. PMID 18258855 DOI: 10.1161/CIRCRESAHA.107.165985 |
0.345 |
|
| 2008 |
Beeri R, Yosefy C, Guerrero JL, Nesta F, Abedat S, Chaput M, del Monte F, Handschumacher MD, Stroud R, Sullivan S, Pugatsch T, Gilon D, Vlahakes GJ, Spinale FG, Hajjar RJ, et al. Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation. Journal of the American College of Cardiology. 51: 476-86. PMID 18222360 DOI: 10.1016/J.Jacc.2007.07.093 |
0.324 |
|
| 2007 |
Sakata S, Liang L, Sakata N, Sakata Y, Chemaly ER, Lebeche D, Takewa Y, Chen J, Park WJ, Kawase Y, Hajjar RJ. Preservation of mechanical and energetic function after adenoviral gene transfer in normal rat hearts. Clinical and Experimental Pharmacology & Physiology. 34: 1300-6. PMID 17973872 DOI: 10.1111/j.1440-1681.2007.04742.x |
0.694 |
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| 2007 |
Kühn B, del Monte F, Hajjar RJ, Chang YS, Lebeche D, Arab S, Keating MT. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nature Medicine. 13: 962-9. PMID 17632525 DOI: 10.1038/nm1619 |
0.679 |
|
| 2007 |
Kaye DM, Preovolos A, Marshall T, Byrne M, Hoshijima M, Hajjar R, Mariani JA, Pepe S, Chien KR, Power JM. Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals. Journal of the American College of Cardiology. 50: 253-60. PMID 17631218 DOI: 10.1016/J.Jacc.2007.03.047 |
0.383 |
|
| 2007 |
Yang DK, Choi BY, Lee YH, Kim YG, Cho MC, Hong SE, Kim DH, Hajjar RJ, Park WJ. Gene profiling during regression of pressure overload-induced cardiac hypertrophy. Physiological Genomics. 30: 1-7. PMID 17327491 DOI: 10.1152/physiolgenomics.00246.2006 |
0.386 |
|
| 2007 |
Sakata S, Lebeche D, Sakata N, Sakata Y, Chemaly ER, Liang LF, Tsuji T, Takewa Y, del Monte F, Peluso R, Zsebo K, Jeong D, Park WJ, Kawase Y, Hajjar RJ. Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins. Journal of Molecular and Cellular Cardiology. 42: 852-61. PMID 17300800 DOI: 10.1016/j.yjmcc.2007.01.003 |
0.63 |
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| 2007 |
Sakata S, Lebeche D, Sakata N, Sakata Y, Chemaly ER, Liang LF, Takewa Y, Jeong D, Park WJ, Kawase Y, Hajjar RJ. Targeted gene transfer increases contractility and decreases oxygen cost of contractility in normal rat hearts. American Journal of Physiology. Heart and Circulatory Physiology. 292: H2356-63. PMID 17220178 DOI: 10.1152/ajpheart.01310.2006 |
0.672 |
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| 2007 |
Sakata S, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang L, Nakajima-Takenaka C, Tsuji T, Konishi N, del Monte F, Hajjar RJ, Takaki M. Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model. American Journal of Physiology. Heart and Circulatory Physiology. 292: H1204-7. PMID 17012346 DOI: 10.1152/ajpheart.00892.2006 |
0.655 |
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| 2006 |
Pyo RT, Sui J, Dhume A, Palomeque J, Blaxall BC, Diaz G, Tunstead J, Logothetis DE, Hajjar RJ, Schecter AD. CXCR4 modulates contractility in adult cardiac myocytes. Journal of Molecular and Cellular Cardiology. 41: 834-44. PMID 17010372 DOI: 10.1016/J.Yjmcc.2006.08.008 |
0.387 |
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| 2006 |
Prunier F, Pfister O, Hadri L, Liang L, Del Monte F, Liao R, Hajjar RJ. Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells. American Journal of Physiology. Heart and Circulatory Physiology. 292: H522-9. PMID 16997893 DOI: 10.1152/ajpheart.00357.2006 |
0.301 |
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| 2006 |
Jeong D, Cha H, Kim E, Kang M, Yang DK, Kim JM, Yoon PO, Oh JG, Bernecker OY, Sakata S, Le TT, Cui L, Lee YH, Kim do H, Woo SH, ... ... Hajjar RJ, et al. PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility. Circulation Research. 99: 307-14. PMID 16809552 DOI: 10.1161/01.Res.0000234780.06115.2C |
0.446 |
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| 2006 |
Gianni D, Chan J, Gwathmey JK, del Monte F, Hajjar RJ. SERCA2a in heart failure: role and therapeutic prospects. Journal of Bioenergetics and Biomembranes. 37: 375-80. PMID 16691468 DOI: 10.1007/s10863-005-9474-z |
0.308 |
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| 2006 |
Lebeche D, Kaprielian R, Hajjar R. Modulation of action potential duration on myocyte hypertrophic pathways. Journal of Molecular and Cellular Cardiology. 40: 725-35. PMID 16600293 DOI: 10.1016/J.Yjmcc.2006.01.018 |
0.671 |
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| 2006 |
Sakata S, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang LF, Padmanabhan P, Konishi N, Takaki M, del Monte F, Hajjar RJ. Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 987-96. PMID 16503203 DOI: 10.1016/j.ymthe.2006.01.002 |
0.676 |
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| 2006 |
Hajjar RJ, Leopold JA. Xanthine oxidase inhibition and heart failure: novel therapeutic strategy for ventricular dysfunction? Circulation Research. 98: 169-71. PMID 16456108 DOI: 10.1161/01.RES.0000204557.09610.01 |
0.332 |
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| 2006 |
Dally S, Bredoux R, Corvazier E, Andersen JP, Clausen JD, Dode L, Fanchaouy M, Gelebart P, Monceau V, Del Monte F, Gwathmey JK, Hajjar R, Chaabane C, Bobe R, Raies A, et al. Ca2+-ATPases in non-failing and failing heart: Evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c) Biochemical Journal. 395: 249-258. PMID 16402920 DOI: 10.1042/BJ20051427 |
0.331 |
|
| 2005 |
Lebeche D, Dalal R, Jang M, del Monte F, Hajjar RJ. Transgenic models of heart failure: elucidation of the molecular mechanisms of heart disease. Heart Failure Clinics. 1: 219-36. PMID 17386848 DOI: 10.1016/j.hfc.2005.03.005 |
0.659 |
|
| 2005 |
Schmidt U, Zhu X, Lebeche D, Huq F, Guerrero JL, Hajjar RJ. In vivo gene transfer of parvalbumin improves diastolic function in aged rat hearts. Cardiovascular Research. 66: 318-23. PMID 15820200 DOI: 10.1016/j.cardiores.2004.06.028 |
0.698 |
|
| 2005 |
Zhu X, Bernecker OY, Manohar NS, Hajjar RJ, Hellman J, Ichinose F, Valdivia HH, Schmidt U. Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis Critical Care Medicine. 33: 598-604. PMID 15753753 DOI: 10.1097/01.CCM.0000152223.27176.A6 |
0.33 |
|
| 2005 |
Pathak A, del Monte F, Zhao W, Schultz JE, Lorenz JN, Bodi I, Weiser D, Hahn H, Carr AN, Syed F, Mavila N, Jha L, Qian J, Marreez Y, Chen G, ... ... Hajjar RJ, et al. Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. Circulation Research. 96: 756-66. PMID 15746443 DOI: 10.1161/01.Res.0000161256.85833.Fa |
0.42 |
|
| 2005 |
Jain M, Pfister O, Hajjar RJ, Liao R. Mesenchymal stem cells in the infarcted heart. Coronary Artery Disease. 16: 93-7. PMID 15735401 DOI: 10.1097/00019501-200503000-00003 |
0.335 |
|
| 2005 |
del Monte F, Kizana E, Tabchy A, Hajjar RJ. Targeted gene transfer in heart failure: implications for novel gene identification. Current Opinion in Molecular Therapeutics. 6: 381-94. PMID 15468597 |
0.319 |
|
| 2004 |
Lebeche D, Kaprielian R, del Monte F, Tomaselli G, Gwathmey JK, Schwartz A, Hajjar RJ. In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis. Circulation. 110: 3435-43. PMID 15557376 DOI: 10.1161/01.Cir.0000148176.33730.3F |
0.682 |
|
| 2004 |
Boecker W, Bernecker OY, Wu JC, Zhu X, Sawa T, Grazette L, Rosenzweig A, del Monte F, Schmidt U, Hajjar RJ. Cardiac-specific gene expression facilitated by an enhanced myosin light chain promoter. Molecular Imaging. 3: 69-75. PMID 15296671 DOI: 10.1162/1535350041464847 |
0.334 |
|
| 2004 |
Del Monte F, Dalal R, Tabchy A, Couget J, Bloch KD, Peterson R, Hajjar RJ. Transcriptional changes following restoration of SERCA2a levels in failing rat hearts. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1474-6. PMID 15247151 DOI: 10.1096/Fj.04-1714Fje |
0.357 |
|
| 2004 |
Huq F, Lebeche D, Iyer V, Liao R, Hajjar RJ. Gene transfer of parvalbumin improves diastolic dysfunction in senescent myocytes. Circulation. 109: 2780-5. PMID 15173024 DOI: 10.1161/01.CIR.0000131764.62242.96 |
0.653 |
|
| 2004 |
Chaudhri BB, Del Monte F, Harding SE, Hajjar RJ. Gene transfer in cardiac myocytes Surgical Clinics of North America. 84: 141-159. PMID 15053187 DOI: 10.1016/S0039-6109(03)00209-3 |
0.303 |
|
| 2004 |
del Monte F, Lebeche D, Guerrero JL, Tsuji T, Doye AA, Gwathmey JK, Hajjar RJ. Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. Proceedings of the National Academy of Sciences of the United States of America. 101: 5622-7. PMID 15044708 DOI: 10.1073/pnas.0305778101 |
0.693 |
|
| 2004 |
Bernecker OY, del Monte F, Hajjar RJ. Gene therapy for the treatment of heart failure--calcium signaling. Seminars in Thoracic and Cardiovascular Surgery. 15: 268-76. PMID 12973704 DOI: 10.1016/s1043-0679(03)70006-9 |
0.349 |
|
| 2003 |
Bernecker OY, Huq F, Heist EK, Podesser BK, Hajjar RJ. Apoptosis in heart failure and the senescent heart. Cardiovascular Toxicology. 3: 183-90. PMID 14555785 DOI: 10.1385/CT:3:3:183 |
0.313 |
|
| 2003 |
Okafor CC, Perreault-Micale C, Hajjar RJ, Lebeche D, Skiroman K, Jabbour G, Doye AA, Lee MX, Laste N, Gwathmey JK. Chronic treatment with carvedilol improves ventricular function and reduces myocyte apoptosis in an animal model of heart failure Bmc Physiology [Electronic Resource]. 3: 6. PMID 12873352 DOI: 10.1186/1472-6793-3-1 |
0.667 |
|
| 2003 |
MacNeill BD, Hayase M, Hajjar RJ. Targeting signaling pathways in heart failure by gene transfer. Current Atherosclerosis Reports. 5: 178-85. PMID 12667429 DOI: 10.1007/s11883-003-0021-2 |
0.305 |
|
| 2003 |
Communal C, Huq F, Lebeche D, Mestel C, Gwathmey JK, Hajjar RJ. Decreased efficiency of adenovirus-mediated gene transfer in aging cardiomyocytes. Circulation. 107: 1170-5. PMID 12615797 |
0.607 |
|
| 2003 |
del Monte F, Hajjar RJ. Targeting calcium cycling proteins in heart failure through gene transfer. The Journal of Physiology. 546: 49-61. PMID 12509478 DOI: 10.1113/jphysiol.2002.026732 |
0.39 |
|
| 2003 |
Okafor CC, Saunders L, Li X, Ito T, Dixon M, Stepenek A, Hajjar RJ, Wood JR, Doye AA, Gwathmey JK. Myofibrillar responsiveness to cAMP, PKA, and caffeine in an animal model of heart failure. Biochemical and Biophysical Research Communications. 300: 592-9. PMID 12504124 DOI: 10.1016/S0006-291X(02)02885-1 |
0.309 |
|
| 2002 |
Huq F, Del Monte F, Hajjar RJ. Modulating signaling pathways in hypertrophy and heart failure by gene transfer. Journal of Cardiac Failure. 8: S389-400. PMID 12555151 DOI: 10.1054/jcaf.2002.129249 |
0.357 |
|
| 2002 |
Kaprielian R, del Monte F, Hajjar RJ. Targeting Ca2+ cycling proteins and the action potential in heart failure by gene transfer. Basic Research in Cardiology. 97: I136-45. PMID 12479247 DOI: 10.1007/S003950200042 |
0.338 |
|
| 2002 |
Neagoe C, Kulke M, del Monte F, Gwathmey JK, de Tombe PP, Hajjar RJ, Linke WA. Titin isoform switch in ischemic human heart disease. Circulation. 106: 1333-41. PMID 12221049 DOI: 10.1161/01.CIR.0000029803.93022.93 |
0.395 |
|
| 2002 |
Carr AN, Schmidt AG, Suzuki Y, del Monte F, Sato Y, Lanner C, Breeden K, Jing SL, Allen PB, Greengard P, Yatani A, Hoit BD, Grupp IL, Hajjar RJ, DePaoli-Roach AA, et al. Type 1 phosphatase, a negative regulator of cardiac function. Molecular and Cellular Biology. 22: 4124-35. PMID 12024026 DOI: 10.1128/Mcb.22.12.4124-4135.2002 |
0.39 |
|
| 2002 |
Communal C, Sumandea M, de Tombe P, Narula J, Solaro RJ, Hajjar RJ. Functional consequences of caspase activation in cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 99: 6252-6. PMID 11972044 DOI: 10.1073/Pnas.092022999 |
0.302 |
|
| 2002 |
Del Monte F, Butler K, Boecker W, Gwathmey JK, Hajjar RJ. Novel technique of aortic banding followed by gene transfer during hypertrophy and heart failure. Physiological Genomics. 9: 49-56. PMID 11948290 DOI: 10.1152/physiolgenomics.00035.2001 |
0.379 |
|
| 2002 |
del Monte F, Harding SE, Dec GW, Gwathmey JK, Hajjar RJ. Targeting phospholamban by gene transfer in human heart failure. Circulation. 105: 904-7. PMID 11864915 DOI: 10.1161/hc0802.105564 |
0.357 |
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