| Year |
Citation |
Score |
| 2022 |
Dhillon RS, Qin YA, van Ginkel PR, Fu VX, Vann JM, Lawton AJ, Green CL, Manchado-Gobatto FB, Gobatto CA, Lamming DW, Prolla TA, Denu JM. SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction. Aging Cell. e13721. PMID 36199173 DOI: 10.1111/acel.13721 |
0.329 |
|
| 2020 |
Kuroki R, Murata Y, Fuke S, Nakachi Y, Nakashima J, Kujoth GC, Prolla TA, Bundo M, Kato T, Iwamoto K. Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition. Frontiers in Genetics. 11: 519206. PMID 33193604 DOI: 10.3389/Fgene.2020.519206 |
0.382 |
|
| 2020 |
Serna E, Mastaloudis A, Martorell P, Wood SM, Hester SN, Bartlett M, Prolla TA, Viña J. A Novel Micronutrient Blend Mimics Calorie Restriction Transcriptomics in Multiple Tissues of Mice and Increases Lifespan and Mobility in . Nutrients. 12. PMID 32075050 DOI: 10.3390/Nu12020486 |
0.37 |
|
| 2020 |
Geurts J, Nasi S, Distel P, Müller-Gerbl M, Prolla TA, Kujoth GC, Walker UA, Hügle T. Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis features. Scientific Reports. 10: 1296. PMID 31992827 DOI: 10.1038/S41598-020-58385-W |
0.453 |
|
| 2019 |
Kim MJ, Haroon S, Chen GD, Ding D, Wanagat J, Liu L, Zhang Y, White K, Park HJ, Han C, Boyd K, Caicedo I, Evans K, Linser PJ, Tanokura M, ... Prolla T, et al. Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice. Experimental Gerontology. 110675. PMID 31344454 DOI: 10.1016/J.Exger.2019.110675 |
0.481 |
|
| 2019 |
Scariot PPM, Manchado-Gobatto FB, Prolla TA, Masselli Dos Reis IG, Gobatto CA. Housing conditions modulate spontaneous physical activity, feeding behavior, aerobic running capacity and adiposity in C57BL/6J mice. Hormones and Behavior. PMID 31310763 DOI: 10.1016/J.Yhbeh.2019.07.004 |
0.312 |
|
| 2019 |
Kuroki R, Murata Y, Fuke S, Kujoth GC, Prolla TA, Kato T, Bundo M, Iwamoto K. M50 Establishment Of Qpcr Protocol For Quantifying The Copy Number Of Active Line-1 Subfamilies In Mice And Its Application To The Aging Mice European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2019.08.150 |
0.384 |
|
| 2018 |
Delic V, Noble K, Zivkovic S, Phan TA, Reynes C, Zhang Y, Phillips O, Claybaker C, Ta Y, Dinh VB, Cruz J, Prolla TA, Bradshaw PC. The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts. Biology Open. PMID 30177551 DOI: 10.1242/Bio.033852 |
0.791 |
|
| 2018 |
Geurts J, Nasi S, Prolla TA, Kujoth GC, Walker UA, Hügle T. SAT0071 Subchondral osteopenia but not cartilage damage is prevalent in knee joints of prematurely ageing mitochondrial dna mutator mice Annals of the Rheumatic Diseases. 77: 898-898. DOI: 10.1136/Annrheumdis-2018-Eular.1065 |
0.425 |
|
| 2018 |
Mastaloudis A, Serna E, Wood S, Hester S, Weindruch R, Prolla T, Viña J. A novel nutrient blend mimics calorie restriction transcriptomics in multiple tissues of mice and increases vitality and lifespan in C. elegans Free Radical Biology and Medicine. 120: S15. DOI: 10.1016/J.Freeradbiomed.2018.04.066 |
0.671 |
|
| 2017 |
Barger JL, Vann JM, Cray NL, Pugh TD, Mastaloudis A, Hester SN, Wood SM, Newton MA, Weindruch R, Prolla TA. Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics. Aging Cell. PMID 28556428 DOI: 10.1111/Acel.12608 |
0.633 |
|
| 2017 |
Someya S, Kujoth GC, Kim MJ, Hacker TA, Vermulst M, Weindruch R, Prolla TA. Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice. Plos One. 12: e0171159. PMID 28158260 DOI: 10.1371/Journal.Pone.0171159 |
0.668 |
|
| 2017 |
Han C, Linser P, Park H, Kim M, White K, Vann JM, Ding D, Prolla TA, Someya S. Note in reference to “Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice” [Neurobiol. Aging 43 (2016) 58–71] Neurobiology of Aging. 59: 222. DOI: 10.1016/J.Neurobiolaging.2017.09.015 |
0.422 |
|
| 2017 |
Mastaloudis A, Serna E, Wood SM, Hester S, Weindruch R, Prolla TA, Vina J. A novel nutrient blend mimics calorie restriction transcriptomics differentially in multiple tissues of mice Free Radical Biology and Medicine. 108: S99. DOI: 10.1016/J.Freeradbiomed.2017.04.320 |
0.684 |
|
| 2016 |
Han C, Linser P, Park HJ, Kim MJ, White K, Vann JM, Ding D, Prolla TA, Someya S. Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice. Neurobiology of Aging. 43: 58-71. PMID 27255815 DOI: 10.1016/J.Neurobiolaging.2016.03.023 |
0.455 |
|
| 2015 |
Safdar A, Khrapko K, Flynn JM, Saleem A, De Lisio M, Johnston AP, Kratysberg Y, Samjoo IA, Kitaoka Y, Ogborn DI, Little JP, Raha S, Parise G, Akhtar M, Hettinga BP, ... ... Prolla TA, et al. Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice. Skeletal Muscle. 6: 7. PMID 26834962 DOI: 10.1186/S13395-016-0075-9 |
0.375 |
|
| 2015 |
Orogo AM, Gonzalez ER, Kubli DA, Baptista IL, Ong SB, Prolla TA, Sussman MA, Murphy AN, Gustafsson ÅB. Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival. The Journal of Biological Chemistry. PMID 26183775 DOI: 10.1074/Jbc.M115.649657 |
0.393 |
|
| 2015 |
Dittenhafer-Reed KE, Richards AL, Fan J, Smallegan MJ, Fotuhi Siahpirani A, Kemmerer ZA, Prolla TA, Roy S, Coon JJ, Denu JM. SIRT3 mediates multi-tissue coupling for metabolic fuel switching. Cell Metabolism. 21: 637-46. PMID 25863253 DOI: 10.1016/J.Cmet.2015.03.007 |
0.386 |
|
| 2015 |
Barger JL, Anderson RM, Newton MA, da Silva C, Vann JA, Pugh TD, Someya S, Prolla TA, Weindruch R. A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3. Plos One. 10: e0120738. PMID 25830335 DOI: 10.1371/Journal.Pone.0120738 |
0.673 |
|
| 2015 |
Li-Harms X, Milasta S, Lynch J, Wright C, Joshi A, Iyengar R, Neale G, Wang X, Wang YD, Prolla TA, Thompson JE, Opferman JT, Green DR, Schuetz J, Kundu M. Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice. Blood. 125: 162-74. PMID 25411424 DOI: 10.1182/Blood-2014-07-586396 |
0.415 |
|
| 2015 |
Geurts J, Distel P, Müller-Gerbl M, Prolla T, Kujoth G, Walker U, Hügle T. AB0109 Increased Subchondral Bone Resorption in the Absence of Osteoarthritis in a Mtdna Mutator Mouse Model of Premature Aging Annals of the Rheumatic Diseases. 74: 927.1-927. DOI: 10.1136/Annrheumdis-2015-Eular.4579 |
0.435 |
|
| 2014 |
Fuke S, Kametani M, Yamada K, Kasahara T, Kubota-Sakashita M, Kujoth GC, Prolla TA, Hitoshi S, Kato T. Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions. Annals of Clinical and Translational Neurology. 1: 909-20. PMID 25540805 DOI: 10.1002/Acn3.133 |
0.472 |
|
| 2014 |
Dai Y, Clark J, Zheng K, Kujoth GC, Prolla TA, Simon DK. Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice. Neurotoxicology and Teratology. 46: 62-7. PMID 25450660 DOI: 10.1016/J.Ntt.2014.10.004 |
0.45 |
|
| 2014 |
Kukreja L, Kujoth GC, Prolla TA, Van Leuven F, Vassar R. Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Molecular Neurodegeneration. 9: 16. PMID 24885175 DOI: 10.1186/1750-1326-9-16 |
0.438 |
|
| 2014 |
Prolla TA, Denu JM. NAD+ deficiency in age-related mitochondrial dysfunction. Cell Metabolism. 19: 178-80. PMID 24506863 DOI: 10.1016/J.Cmet.2014.01.005 |
0.46 |
|
| 2014 |
Taylor SD, Ericson NG, Burton JN, Prolla TA, Silber JR, Shendure J, Bielas JH. Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain Aging Cell. 13: 29-38. PMID 23911137 DOI: 10.1111/Acel.12146 |
0.432 |
|
| 2014 |
Barger J, Vann J, Mastaloudis A, Wood S, Bartlett M, Prolla T, Weindruch R. Identification of transcriptional targets of healthspan in adipose tissue and modulation by resveratrol Nutrition and Aging. 2: 157-163. DOI: 10.3233/NUA-130018 |
0.477 |
|
| 2014 |
Xiao R, Spangler L, Routt K, Lan Z, Johnson C, Prolla TA, Power RF. Supplementation of selenium-enriched yeast attenuates age-dependent transcriptional changes of heart in mitochondrial DNA mutator mice Functional Foods in Health and Disease. 4: 98. DOI: 10.31989/Ffhd.V4I3.22 |
0.523 |
|
| 2013 |
Collino S, Martin FP, Montoliu I, Barger JL, Da Silva L, Prolla TA, Weindruch R, Kochhar S. Transcriptomics and Metabonomics Identify Essential Metabolic Signatures in Calorie Restriction (CR) Regulation across Multiple Mouse Strains. Metabolites. 3: 881-911. PMID 24958256 DOI: 10.3390/Metabo3040881 |
0.629 |
|
| 2013 |
Joseph AM, Adhihetty PJ, Wawrzyniak NR, Wohlgemuth SE, Picca A, Kujoth GC, Prolla TA, Leeuwenburgh C. Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging. Plos One. 8: e69327. PMID 23935986 DOI: 10.1371/Journal.Pone.0069327 |
0.459 |
|
| 2013 |
Perier C, Bender A, García-Arumí E, Melià MJ, Bové J, Laub C, Klopstock T, Elstner M, Mounsey RB, Teismann P, Prolla T, Andreu AL, Vila M. Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms. Brain : a Journal of Neurology. 136: 2369-78. PMID 23884809 DOI: 10.1093/Brain/Awt196 |
0.358 |
|
| 2013 |
Dai Y, Kiselak T, Clark J, Clore E, Zheng K, Cheng A, Kujoth GC, Prolla TA, Maratos-Flier E, Simon DK. Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice. Mitochondrion. 13: 282-91. PMID 23542163 DOI: 10.1016/J.Mito.2013.03.006 |
0.421 |
|
| 2013 |
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, et al. Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Molecular Cell. 49: 186-99. PMID 23201123 DOI: 10.1016/J.Molcel.2012.10.024 |
0.371 |
|
| 2012 |
Dillon LM, Hida A, Garcia S, Prolla TA, Moraes CT. Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse. Plos One. 7: e44335. PMID 22962610 DOI: 10.1371/Journal.Pone.0044335 |
0.467 |
|
| 2012 |
Dillon LM, Williams SL, Hida A, Peacock JD, Prolla TA, Lincoln J, Moraes CT. Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse. Human Molecular Genetics. 21: 2288-97. PMID 22357654 DOI: 10.1093/Hmg/Dds049 |
0.445 |
|
| 2012 |
Fox RG, Magness S, Kujoth GC, Prolla TA, Maeda N. Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G914-24. PMID 22345551 DOI: 10.1152/Ajpgi.00402.2011 |
0.417 |
|
| 2012 |
Ahlqvist KJ, Hämäläinen RH, Yatsuga S, Uutela M, Terzioglu M, Götz A, Forsström S, Salven P, Angers-Loustau A, Kopra OH, Tyynismaa H, Larsson NG, Wartiovaara K, Prolla T, Trifunovic A, et al. Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. Cell Metabolism. 15: 100-9. PMID 22225879 DOI: 10.1016/J.Cmet.2011.11.012 |
0.432 |
|
| 2012 |
Barger JL, Kayo T, Pugh TD, Vann JA, Power R, Dawson K, Weindruch R, Prolla TA. Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse. Genes & Nutrition. 7: 155-65. PMID 21847681 DOI: 10.1007/S12263-011-0243-9 |
0.642 |
|
| 2012 |
Mastaloudis⁎ A, Barger J, Prolla T, Weindruch R, Wood S. A unique blend of natural compounds opposes age-related changes in gene expression related to dysregulation of cellular detoxification and antioxidant protection Free Radical Biology and Medicine. 53: S83. DOI: 10.1016/J.Freeradbiomed.2012.08.173 |
0.647 |
|
| 2011 |
Fox R, Kim HS, Reddick RL, Kujoth GC, Prolla TA, Tsutsumi S, Wada Y, Smithies O, Maeda N. Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite. Proceedings of the National Academy of Sciences of the United States of America. 108: 8779-84. PMID 21555558 DOI: 10.1073/Pnas.1106344108 |
0.436 |
|
| 2011 |
Safdar A, Bourgeois JM, Ogborn DI, Little JP, Hettinga BP, Akhtar M, Thompson JE, Melov S, Mocellin NJ, Kujoth GC, Prolla TA, Tarnopolsky MA. Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 4135-40. PMID 21368114 DOI: 10.1073/Pnas.1019581108 |
0.437 |
|
| 2011 |
Dai DF, Johnson SC, Villarin JJ, Chin MT, Nieves-Cintrón M, Chen T, Marcinek DJ, Dorn GW, Kang YJ, Prolla TA, Santana LF, Rabinovitch PS. Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure. Circulation Research. 108: 837-46. PMID 21311045 DOI: 10.1161/Circresaha.110.232306 |
0.325 |
|
| 2011 |
Hallows WC, Yu W, Smith BC, Devries MK, Devires MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Molecular Cell. 41: 139-49. PMID 21255725 DOI: 10.1016/J.Molcel.2011.01.002 |
0.381 |
|
| 2011 |
Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA. The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell. 10: 55-65. PMID 21040401 DOI: 10.1111/J.1474-9726.2010.00641.X |
0.347 |
|
| 2011 |
Antolic A, Safdar A, Bourgeois JM, Hettinga BP, Wohl GR, Kujoth GC, Prolla TA, Tarnopolsky MA. Endurance Training Improves Vertebral mtDNA Copy Number In Polymerase Gamma Mutator Mouse Model Of Aging Medicine & Science in Sports & Exercise. 43: 245-246. DOI: 10.1249/01.Mss.0000400670.44810.7F |
0.363 |
|
| 2011 |
Tan N, Barger JL, Zhang Y, Ferguson SB, Wu Z, Prolla TA, Bartlett M, Zhu J. The lifespan‐extending effect of Cordyceps sinensis Cs‐4 in normal mice and its molecular mechanisms The Faseb Journal. 25. DOI: 10.1096/Fasebj.25.1_Supplement.599.1 |
0.451 |
|
| 2011 |
Tan N, Barger JL, Zhang Y, Ferguson SB, Wu Z, Prolla TA, Bartlett M, Zhu J. Cordyceps sinensis Cs‐4 restores aging‐associated changes in gene expression and extends lifespan in normal aged mice The Faseb Journal. 25. DOI: 10.1096/Fasebj.25.1_Supplement.1090.13 |
0.464 |
|
| 2011 |
Safdar⁎ A, Melov S, Akhtar M, Kujoth GC, Prolla TA, Hettinga BP, Tarnopolsky MA. Endurance exercise reduces mitochondrial DNA random point mutations and reverses the premature aging transcriptome in PolG mutator mouse: I believe in miracle! Mitochondrion. 11: 665-666. DOI: 10.1016/J.Mito.2011.03.089 |
0.381 |
|
| 2011 |
Chen ML, Logan TD, Hochberg M, Wilding GE, Tan W, Kujoth G, Prolla TA, Carroll M, Thompson⁎ JE. Mitochondrial DNA mutations provide selective advantage in hematopoietic stem cell niche Mitochondrion. 11: 661. DOI: 10.1016/J.Mito.2011.03.077 |
0.305 |
|
| 2011 |
Dillon⁎ LM, Prolla TA, Moraes CT. The effect of increased mitochondrial biogenesis on premature aging Mitochondrion. 11: 646. DOI: 10.1016/J.Mito.2011.03.036 |
0.433 |
|
| 2010 |
Williams SL, Huang J, Edwards YJ, Ulloa RH, Dillon LM, Prolla TA, Vance JM, Moraes CT, Züchner S. The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers. Cell Metabolism. 12: 675-82. PMID 21109200 DOI: 10.1016/J.Cmet.2010.11.012 |
0.392 |
|
| 2010 |
Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell. 143: 802-12. PMID 21094524 DOI: 10.1016/J.Cell.2010.10.002 |
0.476 |
|
| 2010 |
Prolla TA, Bohr VA, de Souza-Pinto NC. Mitochondria and aging. Mechanisms of Ageing and Development. 131: 449-50. PMID 20643157 DOI: 10.1016/J.Mad.2010.07.002 |
0.465 |
|
| 2010 |
Hiona A, Sanz A, Kujoth GC, Pamplona R, Seo AY, Hofer T, Someya S, Miyakawa T, Nakayama C, Samhan-Arias AK, Servais S, Barger JL, Portero-OtÃn M, Tanokura M, Prolla TA, et al. Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. Plos One. 5: e11468. PMID 20628647 DOI: 10.1371/Journal.Pone.0011468 |
0.398 |
|
| 2010 |
Dai DF, Chen T, Wanagat J, Laflamme M, Marcinek DJ, Emond MJ, Ngo CP, Prolla TA, Rabinovitch PS. Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging Cell. 9: 536-44. PMID 20456298 DOI: 10.1111/J.1474-9726.2010.00581.X |
0.48 |
|
| 2010 |
Xu J, Marzetti E, Seo AY, Kim JS, Prolla TA, Leeuwenburgh C. The emerging role of iron dyshomeostasis in the mitochondrial decay of aging. Mechanisms of Ageing and Development. 131: 487-93. PMID 20434480 DOI: 10.1016/J.Mad.2010.04.007 |
0.338 |
|
| 2010 |
Someya S, Prolla TA. Mitochondrial oxidative damage and apoptosis in age-related hearing loss. Mechanisms of Ageing and Development. 131: 480-6. PMID 20434479 DOI: 10.1016/J.Mad.2010.04.006 |
0.461 |
|
| 2010 |
Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell. 141: 280-9. PMID 20403324 DOI: 10.1016/J.Cell.2010.02.026 |
0.356 |
|
| 2010 |
Someya S, Tanokura M, Weindruch R, Prolla TA, Yamasoba T. Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys. Current Aging Science. 3: 20-5. PMID 20298166 DOI: 10.2174/1874609811003010020 |
0.658 |
|
| 2010 |
Safdar A, Abadi A, Akhtar M, Kujoth GC, Prolla TA, Hettinga BP, Tarnopolsky MA. 121 Mitochondrial aging countermeasure—Endurance exercise confers complete phenotypic protection in PolG mutator mouse Mitochondrion. 10: 233-234. DOI: 10.1016/J.Mito.2009.12.112 |
0.398 |
|
| 2009 |
Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, Rabinovitch PS, Weindruch R, Leeuwenburgh C, Tanokura M, Prolla TA. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 106: 19432-7. PMID 19901338 DOI: 10.1073/Pnas.0908786106 |
0.656 |
|
| 2009 |
Chen ML, Logan TD, Hochberg ML, Shelat SG, Yu X, Wilding GE, Tan W, Kujoth GC, Prolla TA, Selak MA, Kundu M, Carroll M, Thompson JE. Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction. Blood. 114: 4045-53. PMID 19734452 DOI: 10.1182/Blood-2008-08-169474 |
0.428 |
|
| 2009 |
Park SK, Kim K, Page GP, Allison DB, Weindruch R, Prolla TA. Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants. Aging Cell. 8: 484-95. PMID 19555370 DOI: 10.1111/J.1474-9726.2009.00496.X |
0.771 |
|
| 2009 |
Anderson R, Prolla T. PGC-1alpha in aging and anti-aging interventions. Biochimica Et Biophysica Acta. 1790: 1059-66. PMID 19371772 DOI: 10.1016/J.Bbagen.2009.04.005 |
0.453 |
|
| 2008 |
Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, ... Prolla TA, et al. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 135: 907-18. PMID 19041753 DOI: 10.1016/J.Cell.2008.10.025 |
0.655 |
|
| 2008 |
Loerch PM, Lu T, Dakin KA, Vann JM, Isaacs A, Geula C, Wang J, Pan Y, Gabuzda DH, Li C, Prolla TA, Yankner BA. Evolution of the aging brain transcriptome and synaptic regulation. Plos One. 3: e3329. PMID 18830410 DOI: 10.1371/Journal.Pone.0003329 |
0.518 |
|
| 2008 |
Barger JL, Kayo T, Pugh TD, Prolla TA, Weindruch R. Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart Experimental Gerontology. 43: 859-866. PMID 18657603 DOI: 10.1016/J.Exger.2008.06.013 |
0.672 |
|
| 2008 |
Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. Plos One. 3: e2264. PMID 18523577 DOI: 10.1371/Journal.Pone.0002264 |
0.675 |
|
| 2008 |
Park SK, Page GP, Kim K, Allison DB, Meydani M, Weindruch R, Prolla TA. alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice. The Journal of Nutrition. 138: 1010-8. PMID 18492827 DOI: 10.1093/Jn/138.6.1010 |
0.769 |
|
| 2008 |
Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice Nature Genetics. 40: 392-394. PMID 18311139 DOI: 10.1038/Ng.95 |
0.45 |
|
| 2008 |
Kujoth GC, Prolla TA. Evolving insight into the role of mitochondrial DNA mutations in aging. Experimental Gerontology. 43: 20-3. PMID 18054193 DOI: 10.1016/J.Exger.2007.09.010 |
0.466 |
|
| 2008 |
Anderson RM, Barger JL, Edwards MG, Braun KH, O'Connor CE, Prolla TA, Weindruch R. Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response. Aging Cell. 7: 101-11. PMID 18031569 DOI: 10.1111/J.1474-9726.2007.00357.X |
0.55 |
|
| 2008 |
Someya S, Yamasoba T, Kujoth GC, Pugh TD, Weindruch R, Tanokura M, Prolla TA. The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma. Neurobiology of Aging. 29: 1080-92. PMID 17363114 DOI: 10.1016/J.Neurobiolaging.2007.01.014 |
0.658 |
|
| 2008 |
Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA. Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice Plos One. 3. DOI: 10.1371/annotation/c54ef754-1962-4125-bf19-76d3ec6f19e5 |
0.582 |
|
| 2008 |
Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA. Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice Plos One. 3. DOI: 10.1371/annotation/8333176c-b08c-4dfb-a829-6331c0fc6064 |
0.582 |
|
| 2008 |
Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA. Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice Plos One. 3. DOI: 10.1371/annotation/7d56e94e-3582-413d-b987-fccd0da79081 |
0.582 |
|
| 2007 |
Someya S, Yamasoba T, Prolla TA, Tanokura M. Genes encoding mitochondrial respiratory chain components are profoundly down-regulated with aging in the cochlea of DBA/2J mice. Brain Research. 1182: 26-33. PMID 17964557 DOI: 10.1016/J.Brainres.2007.08.090 |
0.515 |
|
| 2007 |
Ran Q, Liang H, Ikeno Y, Qi W, Prolla TA, Roberts LJ, Wolf N, Van Remmen H, VanRemmen H, Richardson A. Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 62: 932-42. PMID 17895430 DOI: 10.1093/Gerona/62.9.932 |
0.409 |
|
| 2007 |
Edwards MG, Anderson RM, Yuan M, Kendziorski CM, Weindruch R, Prolla TA. Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program. Bmc Genomics. 8: 80. PMID 17381838 DOI: 10.1186/1471-2164-8-80 |
0.684 |
|
| 2007 |
Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA. Mitochondrial point mutations do not limit the natural lifespan of mice Nature Genetics. 39: 540-543. PMID 17334366 DOI: 10.1038/Ng1988 |
0.431 |
|
| 2007 |
Kujoth GC, Bradshaw PC, Haroon S, Prolla TA. The role of mitochondrial DNA mutations in mammalian aging. Plos Genetics. 3: e24. PMID 17319745 DOI: 10.1371/Journal.Pgen.0030024 |
0.698 |
|
| 2007 |
Sanz A, Hiona A, Kujoth GC, Seo AY, Hofer T, Kouwenhoven E, Kalani R, Prolla TA, Barja G, Leeuwenburgh C. Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice Experimental Gerontology. 42: 173-182. PMID 17118599 DOI: 10.1016/J.Exger.2006.10.003 |
0.372 |
|
| 2007 |
Someya S, Yamasoba T, Weindruch R, Prolla TA, Tanokura M. Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis. Neurobiology of Aging. 28: 1613-22. PMID 16890326 DOI: 10.1016/J.Neurobiolaging.2006.06.024 |
0.636 |
|
| 2007 |
Yamasoba T, Someya S, Yamada C, Weindruch R, Prolla TA, Tanokura M. Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss. Hearing Research. 226: 185-93. PMID 16870370 DOI: 10.1016/J.Heares.2006.06.004 |
0.653 |
|
| 2007 |
Chen M, Kundu M, Shelat S, Kujoth G, Zediak VP, Bhandoola A, Prolla T, Thompson JE. Animal Model of Mitochondrial Dysfunction Generating Macrocytic Anemia and Myelodysplastic Bone Marrow Failure. Blood. 110: 402-402. DOI: 10.1182/Blood.V110.11.402.402 |
0.453 |
|
| 2006 |
Han SN, Adolfsson O, Lee CK, Prolla TA, Ordovas J, Meydani SN. Age and vitamin E-induced changes in gene expression profiles of T cells. Journal of Immunology (Baltimore, Md. : 1950). 177: 6052-61. PMID 17056531 DOI: 10.4049/Jimmunol.177.9.6052 |
0.707 |
|
| 2006 |
Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 126: 941-54. PMID 16959573 DOI: 10.1016/J.Cell.2006.06.057 |
0.567 |
|
| 2006 |
Kujoth GC, Leeuwenburgh C, Prolla TA. Mitochondrial DNA mutations and apoptosis in mammalian aging Cancer Research. 66: 7386-7389. PMID 16885331 DOI: 10.1158/0008-5472.Can-05-4670 |
0.487 |
|
| 2006 |
Leeuwenburgh C, Prolla TA. Genetics, redox signaling, oxidative stress, and apoptosis in mammalian aging Antioxidants and Redox Signaling. 8: 503-505. PMID 16677094 DOI: 10.1089/Ars.2006.8.503 |
0.339 |
|
| 2006 |
Higami Y, Barger JL, Page GP, Allison DB, Smith SR, Prolla TA, Weindruch R. Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue. The Journal of Nutrition. 136: 343-52. PMID 16424110 DOI: 10.1093/Jn/136.2.343 |
0.643 |
|
| 2006 |
Hansen AB, Griner NB, Anderson JP, Kujoth GC, Prolla TA, Loeb LA, Glick E. Mitochondrial DNA integrity is not dependent on DNA polymerase-β activity Dna Repair. 5: 71-79. PMID 16165404 DOI: 10.1016/J.Dnarep.2005.07.009 |
0.356 |
|
| 2006 |
Prolla TA. Gene Expression Profiling of Cardiac Aging: Impact of Caloric Restriction and Other Nutritional Interventions Journal of Cardiac Failure. 12: S153. DOI: 10.1016/J.Cardfail.2006.08.042 |
0.451 |
|
| 2005 |
Scimeca MS, Lisk DJ, Prolla T, Lei XG. Effects of gpx4 haploid insufficiency on GPx4 activity, selenium concentration, and paraquat-induced protein oxidation in murine tissues. Experimental Biology and Medicine (Maywood, N.J.). 230: 709-14. PMID 16246897 DOI: 10.1177/153537020523001003 |
0.358 |
|
| 2005 |
Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, ... ... Prolla TA, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science (New York, N.Y.). 309: 481-4. PMID 16020738 DOI: 10.1126/Science.1112125 |
0.668 |
|
| 2005 |
Park SK, Prolla TA. Gene expression profiling studies of aging in cardiac and skeletal muscles. Cardiovascular Research. 66: 205-12. PMID 15820189 DOI: 10.1016/J.Cardiores.2005.01.005 |
0.688 |
|
| 2005 |
Prolla TA. Multiple roads to the aging phenotype: insights from the molecular dissection of progerias through DNA microarray analysis. Mechanisms of Ageing and Development. 126: 461-5. PMID 15722104 DOI: 10.1016/J.Mad.2004.10.003 |
0.412 |
|
| 2005 |
Park SK, Prolla TA. Lessons learned from gene expression profile studies of aging and caloric restriction. Ageing Research Reviews. 4: 55-65. PMID 15619470 DOI: 10.1016/J.Arr.2004.09.003 |
0.697 |
|
| 2004 |
Han SN, Adolfsson O, Lee CK, Prolla TA, Ordovas J, Meydani SN. Vitamin E and gene expression in immune cells. Annals of the New York Academy of Sciences. 1031: 96-101. PMID 15753137 DOI: 10.1196/Annals.1331.010 |
0.702 |
|
| 2004 |
Bronikowski AM, Rhodes JS, Garland T, Prolla TA, Awad TA, Gammie SC. The evolution of gene expression in mouse hippocampus in response to selective breeding for increased locomotor activity. Evolution; International Journal of Organic Evolution. 58: 2079-86. PMID 15521463 DOI: 10.1111/J.0014-3820.2004.Tb00491.X |
0.445 |
|
| 2004 |
Edwards MG, Sarkar D, Klopp R, Morrow JD, Weindruch R, Prolla TA. Impairment of the transcriptional responses to oxidative stress in the heart of aged C57BL/6 mice. Annals of the New York Academy of Sciences. 1019: 85-95. PMID 15246999 DOI: 10.1196/Annals.1297.017 |
0.704 |
|
| 2004 |
Spach KM, Pedersen LB, Nashold FE, Kayo T, Yandell BS, Prolla TA, Hayes CE. Gene expression analysis suggests that 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by stimulating inflammatory cell apoptosis. Physiological Genomics. 18: 141-51. PMID 15138306 DOI: 10.1152/Physiolgenomics.00003.2004 |
0.36 |
|
| 2004 |
Lee CK, Pugh TD, Klopp RG, Edwards J, Allison DB, Weindruch R, Prolla TA. The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Free Radical Biology & Medicine. 36: 1043-57. PMID 15059645 DOI: 10.1016/J.Freeradbiomed.2004.01.015 |
0.806 |
|
| 2004 |
Higami Y, Pugh TD, Page GP, Allison DB, Prolla TA, Weindruch R. Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 415-7. PMID 14688200 DOI: 10.1096/Fj.03-0678Fje |
0.668 |
|
| 2004 |
Gadbury GL, Page GP, Edwards J, Kayo T, Prolla TA, Weindruch R, Permana PA, Mountz JD, Allison DB. Power and sample size estimation in high dimensional biology Statistical Methods in Medical Research. 13: 325-338. DOI: 10.1191/0962280204Sm369Ra |
0.525 |
|
| 2004 |
Higami Y, Weindruch R, Prolla TA, Shimokawa I. Altered lipid metabolism in rodents subjected to calorie restriction Geriatrics and Gerontology International. 4: S155-S157. DOI: 10.1111/J.1447-0594.2004.00185.X |
0.521 |
|
| 2004 |
Gadbury GL, Page GP, Edwards J, Kayo T, Prolla TA, Weindruch R, Permana PA, Mountz JD, Allison DB. Power and sample size estimation in high dimensional biology Statistical Methods in Medical Research. 13: 325-338. |
0.473 |
|
| 2003 |
Ran Q, Van Remmen H, Gu M, Qi W, Roberts LJ, Prolla T, Richardson A. Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes. Free Radical Biology & Medicine. 35: 1101-9. PMID 14572612 DOI: 10.1016/S0891-5849(03)00466-0 |
0.384 |
|
| 2003 |
Edwards MG, Sarkar D, Klopp R, Morrow JD, Weindruch R, Prolla TA. Age-related impairment of the transcriptional responses to oxidative stress in the mouse heart. Physiological Genomics. 13: 119-27. PMID 12595580 DOI: 10.1152/Physiolgenomics.00172.2002 |
0.705 |
|
| 2003 |
Yant LJ, Ran Q, Rao L, Van Remmen H, Shibatani T, Belter JG, Motta L, Richardson A, Prolla TA. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radical Biology & Medicine. 34: 496-502. PMID 12566075 DOI: 10.1016/S0891-5849(02)01360-6 |
0.384 |
|
| 2003 |
Bronikowski AM, Carter PA, Morgan TJ, Garland T, Ung N, Pugh TD, Weindruch R, Prolla TA. Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart. Physiological Genomics. 12: 129-38. PMID 12429864 DOI: 10.1152/Physiolgenomics.00082.2002 |
0.675 |
|
| 2002 |
Weindruch R, Kayo T, Lee CK, Prolla TA. Effects of caloric restriction on gene expression. Nestlé Nutrition Workshop Series. Clinical & Performance Programme. 6: 17-28; discussion 28. PMID 16969964 |
0.744 |
|
| 2002 |
Weindruch R, Prolla TA. Gene expression profile of the aging brain. Archives of Neurology. 59: 1712-4. PMID 12433256 DOI: 10.1001/Archneur.59.11.1712 |
0.659 |
|
| 2002 |
Lee CK, Allison DB, Brand J, Weindruch R, Prolla TA. Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proceedings of the National Academy of Sciences of the United States of America. 99: 14988-93. PMID 12419851 DOI: 10.1073/Pnas.232308999 |
0.816 |
|
| 2002 |
Prolla TA. DNA microarray analysis of the aging brain. Chemical Senses. 27: 299-306. PMID 11923192 DOI: 10.1093/Chemse/27.3.299 |
0.543 |
|
| 2002 |
Prolla TA, Mattson MP. Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restriction. Trends in Neurosciences. 24: S21-31. PMID 11881742 DOI: 10.1016/S0166-2236(00)01957-3 |
0.43 |
|
| 2002 |
Rao L, Puschner B, Prolla TA. Gene expression profiling of low selenium status in the mouse intestine: transcriptional activation of genes linked to DNA damage, cell cycle control and oxidative stress. The Journal of Nutrition. 131: 3175-81. PMID 11739862 DOI: 10.1093/Jn/131.12.3175 |
0.447 |
|
| 2002 |
Weindruch R, Kayo T, Lee CK, Prolla TA. Gene expression profiling of aging using DNA microarrays. Mechanisms of Ageing and Development. 123: 177-93. PMID 11718811 DOI: 10.1016/S0047-6374(01)00344-X |
0.808 |
|
| 2001 |
Lee CK, Prolla TA, Weindruch R. Caloric Intake, Oxidative Stress and Aging. Thescientificworldjournal. 1: 85. PMID 30147557 DOI: 10.1100/Tsw.2001.117 |
0.822 |
|
| 2001 |
Prolla TA, Allison DB, Weindruch R. Response to "Interpretation, design, and analysis of gene array expression experiments". The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 56: B327-30. PMID 11487590 DOI: 10.1093/GERONA/56.8.B327 |
0.531 |
|
| 2001 |
Kayo T, Allison DB, Weindruch R, Prolla TA. Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proceedings of the National Academy of Sciences of the United States of America. 98: 5093-8. PMID 11309484 DOI: 10.1073/Pnas.081061898 |
0.717 |
|
| 2001 |
Weindruch R, Kayo T, Lee CK, Prolla TA. Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice. The Journal of Nutrition. 131: 918S-923S. PMID 11238786 DOI: 10.1093/Jn/131.3.918S |
0.819 |
|
| 2000 |
Lee CK, Weindruch R, Prolla TA. Gene-expression profile of the ageing brain in mice. Nature Genetics. 25: 294-7. PMID 10888876 DOI: 10.1038/77046 |
0.793 |
|
| 1999 |
Lee CK, Klopp RG, Weindruch R, Prolla TA. Gene expression profile of aging and its retardation by caloric restriction. Science (New York, N.Y.). 285: 1390-3. PMID 10464095 DOI: 10.1126/Science.285.5432.1390 |
0.815 |
|
| 1999 |
Yao X, Buermeyer AB, Narayanan L, Tran D, Baker SM, Prolla TA, Glazer PM, Liskay RM, Arnheim N. Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 6850-5. PMID 10359802 DOI: 10.1073/Pnas.96.12.6850 |
0.363 |
|
| 1998 |
Prolla TA. DNA mismatch repair and cancer. Current Opinion in Cell Biology. 10: 311-6. PMID 9640530 DOI: 10.1016/S0955-0674(98)80005-7 |
0.348 |
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