| Year |
Citation |
Score |
| 2019 |
Rodríguez Y, Gerona-Navarro G, Osman R, Zhou MM. In Silico Design and Molecular Basis for the Selectivity of Olinone Towards the First over the Second Bromodomain of BRD4. Proteins. PMID 31587361 DOI: 10.1002/Prot.25818 |
0.346 |
|
| 2018 |
Brown MC, Abdine A, Chavez J, Schaffner A, Torres-Arancivia C, Lada B, JiJi RD, Osman R, Cooley JW, Ubarretxena-Belandia I. Unwinding of the Substrate Transmembrane Helix in Intramembrane Proteolysis. Biophysical Journal. 114: 1579-1589. PMID 29642028 DOI: 10.1016/J.Bpj.2018.01.043 |
0.36 |
|
| 2016 |
Brown M, Abdine A, Chavez J, Lada B, JiJi RD, Osman R, Cooley JW, Ubarretxena-Bilandia I. Transmembrane Substrate Unfolding in Intramembrane Proteolysis Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.2129 |
0.303 |
|
| 2015 |
Osman R, Mezei M, Engel S. The role of protein "Stability patches" in molecular recognition: A case study of the human growth hormone-receptor complex. Journal of Computational Chemistry. PMID 26691434 DOI: 10.1002/Jcc.24276 |
0.342 |
|
| 2015 |
Maillet EL, Cui M, Jiang P, Mezei M, Hecht E, Quijada J, Margolskee RF, Osman R, Max M. Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor. Chemical Senses. 40: 577-86. PMID 26377607 DOI: 10.1093/Chemse/Bjv045 |
0.313 |
|
| 2015 |
Osman R, Gomez JC, Mezei M, Barak D, Cordomi A, Pardo L. Ligand-G Protein Allosteric Communication through Internal Waters in GPCR Complexes Biophysical Journal. 108: 3-3. DOI: 10.1016/J.Bpj.2014.11.1993 |
0.322 |
|
| 2014 |
Pasi M, Maddocks JH, Beveridge D, Bishop TC, Case DA, Cheatham T, Dans PD, Jayaram B, Lankas F, Laughton C, Mitchell J, Osman R, Orozco M, Pérez A, Petkevi?i?t? D, et al. μABC: a systematic microsecond molecular dynamics study of tetranucleotide sequence effects in B-DNA. Nucleic Acids Research. 42: 12272-83. PMID 25260586 DOI: 10.1093/Nar/Gku855 |
0.382 |
|
| 2013 |
Osman R, Mezei M, Barak D, Cordomi A, Pardo L. The Role of Internal Water in GPCR Complexes Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.266 |
0.322 |
|
| 2012 |
Joseph TT, Osman R. Convergent transmission of RNAi guide-target mismatch information across Argonaute internal allosteric network. Plos Computational Biology. 8: e1002693. PMID 23028290 DOI: 10.1371/Journal.Pcbi.1002693 |
0.564 |
|
| 2012 |
Joseph TT, Osman R. Thermodynamic basis of selectivity in guide-target-mismatched RNA interference. Proteins. 80: 1283-98. PMID 22275138 DOI: 10.1002/Prot.24025 |
0.592 |
|
| 2011 |
Gerona-Navarro G, Yoel-Rodríguez, Mujtaba S, Frasca A, Patel J, Zeng L, Plotnikov AN, Osman R, Zhou MM. Rational design of cyclic peptide modulators of the transcriptional coactivator CBP: a new class of p53 inhibitors. Journal of the American Chemical Society. 133: 2040-3. PMID 21271695 DOI: 10.1021/Ja107761H |
0.311 |
|
| 2011 |
Osman R, Cordomi A, Lazaridis T, Mezei M, Pardo L. Role of Water in Transmembrane Domain of G Protein-Coupled Receptors Biophysical Journal. 100: 20a. DOI: 10.1016/J.Bpj.2010.12.320 |
0.314 |
|
| 2010 |
Menconi F, Osman R, Monti MC, Greenberg DA, Concepcion ES, Tomer Y. Shared molecular amino acid signature in the HLA-DR peptide binding pocket predisposes to both autoimmune diabetes and thyroiditis. Proceedings of the National Academy of Sciences of the United States of America. 107: 16899-903. PMID 20837527 DOI: 10.1073/Pnas.1009511107 |
0.306 |
|
| 2010 |
Lavery R, Zakrzewska K, Beveridge D, Bishop TC, Case DA, Cheatham T, Dixit S, Jayaram B, Lankas F, Laughton C, Maddocks JH, Michon A, Osman R, Orozco M, Perez A, et al. A systematic molecular dynamics study of nearest-neighbor effects on base pair and base pair step conformations and fluctuations in B-DNA. Nucleic Acids Research. 38: 299-313. PMID 19850719 DOI: 10.1093/Nar/Gkp834 |
0.408 |
|
| 2010 |
Eichenbaum KD, Rodríguez Y, Mezei M, Osman R. The energetics of the acetylation switch in p53-mediated transcriptional activation. Proteins. 78: 447-56. PMID 19731376 DOI: 10.1002/Prot.22565 |
0.33 |
|
| 2009 |
Pardo L, Mazurek AP, Osman R, Weinstein H. Theoretical studies of the activation mechanism of histamine H2-receptors: Dimaprit and the receptor model International Journal of Quantum Chemistry. 36: 281-290. DOI: 10.1002/Qua.560360722 |
0.307 |
|
| 2009 |
Weinstein H, Osman R, Edwards WD, Green JP. Theoretical models for molecular mechanisms in biological systems: Tryptamine congeners acting on an LSD—Serotonin receptor International Journal of Quantum Chemistry. 14: 449-461. DOI: 10.1002/Qua.560140742 |
0.311 |
|
| 2008 |
Cui M, Mezei M, Osman R. Prediction of protein loop structures using a local move Monte Carlo approach and a grid-based force field. Protein Engineering, Design & Selection : Peds. 21: 729-35. PMID 18957407 DOI: 10.1093/Protein/Gzn056 |
0.322 |
|
| 2008 |
Menconi F, Monti MC, Greenberg DA, Oashi T, Osman R, Davies TF, Ban Y, Jacobson EM, Concepcion ES, Li CW, Tomer Y. Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 14034-9. PMID 18779568 DOI: 10.1073/Pnas.0806584105 |
0.614 |
|
| 2008 |
Yamoah K, Oashi T, Sarikas A, Gazdoiu S, Osman R, Pan ZQ. Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail. Proceedings of the National Academy of Sciences of the United States of America. 105: 12230-5. PMID 18723677 DOI: 10.1073/Pnas.0806155105 |
0.627 |
|
| 2008 |
Cui M, Mezei M, Osman R. Modeling dimerizations of transmembrane proteins using Brownian dynamics simulations. Journal of Computer-Aided Molecular Design. 22: 553-61. PMID 18338226 DOI: 10.1007/S10822-008-9198-3 |
0.301 |
|
| 2007 |
Kentsis A, Gindin T, Mezei M, Osman R. Calculation of the free energy and cooperativity of protein folding Plos One. 2. PMID 17505540 DOI: 10.1371/Journal.Pone.0000446 |
0.764 |
|
| 2005 |
Kentsis A, Mezei M, Osman R. Origin of the sequence-dependent polyproline II structure in unfolded peptides Proteins: Structure, Function and Genetics. 61: 769-776. PMID 16193481 DOI: 10.1002/Prot.20655 |
0.614 |
|
| 2005 |
Dixit SB, Beveridge DL, Case DA, Cheatham TE, Giudice E, Lankas F, Lavery R, Maddocks JH, Osman R, Sklenar H, Thayer KM, Varnai P. Molecular dynamics simulations of the 136 unique tetranucleotide sequences of DNA oligonucleotides. II: sequence context effects on the dynamical structures of the 10 unique dinucleotide steps. Biophysical Journal. 89: 3721-40. PMID 16169978 DOI: 10.1529/Biophysj.105.067397 |
0.406 |
|
| 2005 |
Fuxreiter M, Mezei M, Simon I, Osman R. Interfacial water as a "hydration fingerprint" in the noncognate complex of BamHI. Biophysical Journal. 89: 903-11. PMID 15894630 DOI: 10.1529/Biophysj.105.063263 |
0.342 |
|
| 2005 |
Jiang P, Cui M, Ji Q, Snyder L, Liu Z, Benard L, Margolskee RF, Osman R, Max M. Molecular mechanisms of sweet receptor function. Chemical Senses. 30: i17-8. PMID 15738096 DOI: 10.1093/Chemse/Bjh091 |
0.3 |
|
| 2005 |
Huang W, Osman R, Gershengorn MC. Agonist-induced conformational changes in thyrotropin-releasing hormone receptor type I: disulfide cross-linking and molecular modeling approaches. Biochemistry. 44: 2419-31. PMID 15709754 DOI: 10.1021/Bi048808+ |
0.344 |
|
| 2005 |
Miller F, Kentsis A, Osman R, Pan ZQ. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL·hypoxia-inducible transcription factor-1α complex Journal of Biological Chemistry. 280: 7985-7996. PMID 15611064 DOI: 10.1074/Jbc.M413160200 |
0.543 |
|
| 2004 |
Beveridge DL, Barreiro G, Byun KS, Case DA, Cheatham TE, Dixit SB, Giudice E, Lankas F, Lavery R, Maddocks JH, Osman R, Seibert E, Sklenar H, Stoll G, Thayer KM, et al. Molecular dynamics simulations of the 136 unique tetranucleotide sequences of DNA oligonucleotides. I. Research design and results on d(CpG) steps. Biophysical Journal. 87: 3799-813. PMID 15326025 DOI: 10.1529/Biophysj.104.045252 |
0.652 |
|
| 2004 |
Lu X, Huang W, Worthington S, Drabik P, Osman R, Gershengorn MC. A model of inverse agonist action at thyrotropin-releasing hormone receptor type 1: role of a conserved tryptophan in helix 6. Molecular Pharmacology. 66: 1192-200. PMID 15306657 DOI: 10.1124/Mol.104.000349 |
0.322 |
|
| 2004 |
Kentsis A, Mezei M, Gindin T, Osman R. Unfolded State of Polyalanine Is a Segmented Polyproline II Helix Proteins: Structure, Function and Genetics. 55: 493-501. PMID 15103613 DOI: 10.1002/Prot.20051 |
0.759 |
|
| 2004 |
Ban Y, Davies TF, Greenberg DA, Concepcion ES, Osman R, Oashi T, Tomer Y. Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves' disease. Genes and Immunity. 5: 203-8. PMID 15029234 DOI: 10.1038/Sj.Gene.6364059 |
0.624 |
|
| 2003 |
Seibert E, Ross JB, Osman R. Contribution of opening and bending dynamics to specific recognition of DNA damage. Journal of Molecular Biology. 330: 687-703. PMID 12850140 DOI: 10.1016/S0022-2836(03)00598-9 |
0.668 |
|
| 2003 |
Kentsis A, Mezei M, Osman R. MC-PHS: A Monte Carlo implementation of the primary hydration shell for protein folding and design Biophysical Journal. 84: 805-815. PMID 12547765 DOI: 10.1016/S0006-3495(03)74900-5 |
0.587 |
|
| 2003 |
Seibert E, Chin AS, Pfleiderer W, Hawkins ME, Laws WR, Osman R, Ross JBA. pH-dependent spectroscopy and electronic structure of the guanine analogue 6,8-dimethylisoxanthopterin Journal of Physical Chemistry A. 107: 178-185. DOI: 10.1021/Jp026904J |
0.653 |
|
| 2003 |
Fuxreiter M, Osman R, Simon I. Computational approaches to restriction endonucleases Journal of Molecular Structure: Theochem. 666: 469-479. DOI: 10.1016/J.Theochem.2003.08.071 |
0.36 |
|
| 2002 |
Fuxreiter M, Luo N, Jedlovszky P, Simon I, Osman R. Role of base flipping in specific recognition of damaged DNA by repair enzymes. Journal of Molecular Biology. 323: 823-34. PMID 12417196 DOI: 10.1016/S0022-2836(02)00999-3 |
0.368 |
|
| 2002 |
Seibert E, Ross JB, Osman R. Role of DNA flexibility in sequence-dependent activity of uracil DNA glycosylase. Biochemistry. 41: 10976-84. PMID 12206669 DOI: 10.1021/Bi026121O |
0.662 |
|
| 2002 |
Seibert E, Ross JBA, Osman R. Quantum mechanical investigation of the electronic structure and spectral properties of 6,8-dimethylisoxanthopterin International Journal of Quantum Chemistry. 88: 28-33. DOI: 10.1002/Qua.10075 |
0.662 |
|
| 2001 |
Rachofsky EL, Ross JB, Osman R. Conformation and dynamics of normal and damaged DNA. Combinatorial Chemistry & High Throughput Screening. 4: 675-706. PMID 11812262 DOI: 10.2174/1386207013330706 |
0.771 |
|
| 2001 |
Rachofsky EL, Seibert E, Stivers JT, Osman R, Ross JB. Conformation and dynamics of abasic sites in DNA investigated by time-resolved fluorescence of 2-aminopurine. Biochemistry. 40: 957-67. PMID 11170417 DOI: 10.1021/Bi001665G |
0.768 |
|
| 2001 |
Rachofsky EL, Osman R, Ross JB. Probing structure and dynamics of DNA with 2-aminopurine: effects of local environment on fluorescence. Biochemistry. 40: 946-56. PMID 11170416 DOI: 10.1021/Bi001664O |
0.762 |
|
| 2001 |
Gershengorn MC, Osman R. Minireview: Insights into G protein-coupled receptor function using molecular models. Endocrinology. 142: 2-10. PMID 11145559 DOI: 10.1210/Endo.142.1.7919 |
0.313 |
|
| 2001 |
Ho HH, Ganeshalingam N, Rosenhouse-Dantsker A, Osman R, Gershengorn MC. Charged residues at the intracellular boundary of transmembrane helices 2 and 3 independently affect constitutive activity of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. The Journal of Biological Chemistry. 276: 1376-82. PMID 11031271 DOI: 10.1074/Jbc.M007885200 |
0.302 |
|
| 2001 |
Rachofsky EL, Ross JBA, Krauss M, Osman R. CASSCF investigation of electronic excited states of 2-aminopurine Journal of Physical Chemistry A. 105: 190-197. DOI: 10.1021/Jp002413S |
0.771 |
|
| 2000 |
Rosenhouse-Dantsker A, Osman R. Application of the primary hydration shell approach to locally enhanced sampling simulated annealing: computer simulation of thyrotropin-releasing hormone in water. Biophysical Journal. 79: 66-79. PMID 10866938 DOI: 10.1016/S0006-3495(00)76274-6 |
0.309 |
|
| 1999 |
Fuxreiter M, Warshel A, Osman R. Role of active site residues in the glycosylase step of T4 endonuclease V. Computer simulation studies on ionization states. Biochemistry. 38: 9577-89. PMID 10423235 DOI: 10.1021/Bi9901937 |
0.363 |
|
| 1999 |
Luo N, Mehler E, Osman R. Specificity and catalysis of uracil DNA glycosylase. A molecular dynamics study of reactant and product complexes with DNA. Biochemistry. 38: 9209-20. PMID 10413495 DOI: 10.1021/Bi990262H |
0.399 |
|
| 1998 |
Yamaguchi H, van Aalten DM, Pinak M, Furukawa A, Osman R. Essential dynamics of DNA containing a cis.syn cyclobutane thymine dimer lesion. Nucleic Acids Research. 26: 1939-46. PMID 9518486 DOI: 10.1093/Nar/26.8.1939 |
0.35 |
|
| 1998 |
Colson AO, Perlman JH, Smolyar A, Gershengorn MC, Osman R. Static and dynamic roles of extracellular loops in G-protein-coupled receptors: a mechanism for sequential binding of thyrotropin-releasing hormone to its receptor. Biophysical Journal. 74: 1087-100. PMID 9512011 DOI: 10.1016/S0006-3495(98)77827-0 |
0.326 |
|
| 1998 |
Rachofsky EL, Ross JBA, Krauss M, Osman R. Spectroscopy of 2-aminopurine: An MCSCF study Acta Physica Polonica A. 94: 735-748. |
0.713 |
|
| 1997 |
Soirat AJA, Wong CF, Osman R, Weinstein H. Brownian dynamics simulations of the reactions of hydrated electrons with components of DNAs and a DNA double-helix Journal of Computational Chemistry. 18: 888-901. DOI: 10.1002/(Sici)1096-987X(199705)18:7<888::Aid-Jcc3>3.0.Co;2-N |
0.369 |
|
| 1996 |
Pinak M, Yamaguchi H, Osman R. Molecular dynamics (MD) simulation of DNA dodecamer with 5-hydroxy-6-cytosinyl radical. Journal of Radiation Research. 37: 20-8. PMID 8699393 DOI: 10.1269/Jrr.37.20 |
0.367 |
|
| 1996 |
Laakkonen LJ, Guarnieri F, Perlman JH, Gershengorn MC, Osman R. A refined model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Novel mixed mode Monte Carlo/stochastic dynamics simulations of the complex between TRH and TRH receptor. Biochemistry. 35: 7651-63. PMID 8672466 DOI: 10.1021/Bi952203J |
0.341 |
|
| 1996 |
Perlman JH, Laakkonen LJ, Guarnieri F, Osman R, Gershengorn MC. A refined model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Experimental analysis and energy minimization of the complex between TRH and TRH receptor. Biochemistry. 35: 7643-50. PMID 8672465 DOI: 10.1021/Bi952202R |
0.302 |
|
| 1996 |
Miaskiewicz K, Miller J, Cooney M, Osman R. Computational simulations of DNA distortions by a cis,syn-cyclobutane thymine dimer lesion Journal of the American Chemical Society. 118: 9156-9163. DOI: 10.1021/Ja9611304 |
0.333 |
|
| 1995 |
Miaskiewicz K, Miller J, Ornstein R, Osman R. Molecular dynamics simulations of the effects of ring-saturated thymine lesions on DNA structure. Biopolymers. 35: 113-24. PMID 7696552 DOI: 10.1002/Bip.360350112 |
0.342 |
|
| 1995 |
Krauss M, Osman R. Electronic spectra of H and OH adducts to benzene Chemical Physics Letters. 239: 258-262. DOI: 10.1016/0009-2614(95)00463-E |
0.319 |
|
| 1994 |
Miller J, Miaskiewicz K, Osman R. Structure-function studies of DNA damage using ab initio quantum mechanics and molecular dynamics simulation. Annals of the New York Academy of Sciences. 726: 71-91. PMID 8092709 DOI: 10.1111/J.1749-6632.1994.Tb52799.X |
0.357 |
|
| 1994 |
Miaskiewicz K, Miller J, Osman R. Energetic basis for structural preferences in 5/6-hydroxy-5,6-dihydropyrimidines: products of ionizing and ultraviolet radiation action on DNA bases. Biochimica Et Biophysica Acta. 1218: 283-91. PMID 8049253 DOI: 10.1016/0167-4781(94)90179-1 |
0.343 |
|
| 1993 |
Pardo L, Osman R, Weinstein H, Rabinowitz JR. Mechanisms of nucleophilic addition to activated double bonds: 1,2- and 1,4-Michael addition of ammonia Journal of the American Chemical Society. 115: 8263-8269. DOI: 10.1021/Ja00071A039 |
0.318 |
|
| 1993 |
Miaskiewicz K, Osman R, Weinstein H. Molecular dynamics simulation of the hydrated d(CGCGAATTCGCG)2 dodecamer Journal of the American Chemical Society. 115: 1526-1537. DOI: 10.1021/Ja00057A045 |
0.378 |
|
| 1992 |
Pardo L, Ballesteros JA, Osman R, Weinstein H. On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three-dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors. Proceedings of the National Academy of Sciences of the United States of America. 89: 4009-12. PMID 1315046 DOI: 10.1073/Pnas.89.9.4009 |
0.369 |
|
| 1992 |
Pardo L, Banfelder JR, Osman R. Theoretical studies of the kinetics, thermochemistry, and mechanism of H-abstraction from methanol and ethanol Journal of the American Chemical Society. 114: 2382-2390. DOI: 10.1021/Ja00033A013 |
0.311 |
|
| 1988 |
Mercier GA, Osman R, Weinstein H. Role of primary and secondary protein structure in neurotransmitter receptor activation mechanisms Protein Engineering, Design and Selection. 2: 261-270. PMID 3074305 DOI: 10.1093/Protein/2.4.261 |
0.337 |
|
| 1985 |
Weinstein H, Rabinowitz J, Liebman MN, Osman R. Determinants of molecular reactivity as criteria for predicting toxicity: problems and approaches. Environmental Health Perspectives. 61: 147-162. PMID 3905371 DOI: 10.1289/Ehp.8561147 |
0.315 |
|
| 1984 |
Topiol S, Weinstein H, Osman R. A theoretical investigation of histamine tautomerism Journal of Medicinal Chemistry. 27: 1531-1533. PMID 6492081 DOI: 10.1021/Jm00377A023 |
0.308 |
|
| 1979 |
Kang S, Ernst L, Weinstein H, Osman R. [13C]NMR Chemical Shifts and Calculated Electronic Structures of Serotonin Congeners: Relation to Biological Activity Molecular Pharmacology. 16: 1031-1039. DOI: 10.1016/B978-0-08-023768-8.52245-3 |
0.326 |
|
| 1977 |
Weinstein H, Osman R. Models for molecular mechanisms in drug—receptor interactions. Serotonin and 5‐hydroxyindole complexes with imidazolium cation International Journal of Quantum Chemistry. 12: 253-268. DOI: 10.1002/Qua.560120726 |
0.318 |
|
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