Kimberly K. Vines, Ph.D.

Affiliations: 
2001 University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Organic Chemistry, Pharmaceutical Chemistry
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Donald D. Muccio grad student 2001 UAB
 (Design of conformationally defined retinoids: Synthesis, nuclear receptor binding, and transcriptional activity of derivatives of (9Z)-UAB30.)
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Desphande A, Xia G, Boerma LJ, et al. (2014) Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. Bioorganic & Medicinal Chemistry. 22: 178-85
Grubbs CJ, Hill DL, Bland KI, et al. (2003) 9cUAB30, an RXR specific retinoid, and/or tamoxifen in the prevention of methylnitrosourea-induced mammary cancers. Cancer Letters. 201: 17-24
Atigadda VR, Vines KK, Grubbs CJ, et al. (2003) Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30). Journal of Medicinal Chemistry. 46: 3766-9
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