James C. Alwine

University of Pennsylvania, Philadelphia, PA, United States 
Molecular Biology, Microbiology Biology
"James Alwine"


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Holly H. Henry grad student 2000 Penn
Newman J. Sund grad student 2001 Penn
Sagar B. Kudchodkar grad student 2007 Penn
Nicholas J. Buchkovich grad student 2010 Penn
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Walton ZE, Patel CH, Brooks RC, et al. (2018) Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Cell
Ochocki JD, Khare S, Hess M, et al. (2018) Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity. Cell Metabolism
Vysochan A, Sengupta A, Weljie AM, et al. (2017) ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection. Proceedings of the National Academy of Sciences of the United States of America
Yu Y, Maguire TG, Alwine JC. (2014) ChREBP, a glucose-responsive transcriptional factor, enhances glucose metabolism to support biosynthesis in human cytomegalovirus-infected cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 1951-6
Yu Y, Pierciey FJ, Maguire TG, et al. (2013) PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection. Plos Pathogens. 9: e1003266
Yu Y, Maguire TG, Alwine JC. (2012) Human cytomegalovirus infection induces adipocyte-like lipogenesis through activation of sterol regulatory element binding protein 1. Journal of Virology. 86: 2942-9
Tilton C, Clippinger AJ, Maguire T, et al. (2011) Human cytomegalovirus induces multiple means to combat reactive oxygen species. Journal of Virology. 85: 12585-93
Yu Y, Clippinger AJ, Pierciey FJ, et al. (2011) Viruses and metabolism: alterations of glucose and glutamine metabolism mediated by human cytomegalovirus. Advances in Virus Research. 80: 49-67
Clippinger AJ, Maguire TG, Alwine JC. (2011) Human cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivation. Journal of Virology. 85: 9369-76
Yu Y, Clippinger AJ, Alwine JC. (2011) Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection. Trends in Microbiology. 19: 360-7
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