Jonathan C. Kagan, Ph.D.
Affiliations: | 2003 | Yale University, New Haven, CT | |
| 2010- | Boston Children's Hospital, Boston, MA, United States |
Area:
Toll-like receptors, myddosomes, signaling, innate immunityWebsite:
https://kaganlab.com/Google:
"Jonathan Kagan"Bio:
Kagan's work identified subdomains of the plasma membrane that permit Toll-like Receptor 4 (TLR4) signaling and identified endosomes as a key site from which TLR4 signaling occurs. These discoveries led to the identification of a novel means by which TLR4 is transported between the cell surface and endosomes via CD14 and MD-2, and in the process revealed endocytosis as a TLR4-independent cellular response to bacterial lipopolysaccharides (LPS).
His lab characterized the endogenous myddosome, a receptor-proximal signaling complex used by most TLRs to stimulate inflammation. The myddosome was proposed to exist from analysis of recombinant death domains derived from the protein MyD88 and the IRAK family kinases in vitro, but whether this complex existed within cells was unclear. Kagan's studies demonstrated that the myddosome is not present in resting cells but is assembled rapidly upon microbial detection by multiple TLRs.
Parents
Sign in to add mentor| Craig R. Roy | grad student | 2003 | Yale | |
| (Cellular and molecular aspects of Legionella pneumophila transport to the endoplasmic reticulum.) | ||||
| Ruslan Medzhitov | post-doc | 2004-2008 | Yale (Chemistry Tree) | |
| (TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta) | ||||
Children
Sign in to add trainee| Karen Jane Kieser | post-doc | Harvard | |
| Daniel Fisch | post-doc | 2023 | Boston Children's Hospital |
Publications
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| Holley CL, Monteleone M, Fisch D, et al. (2024) Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells. Nature Immunology |
| Wang Y, Zhang Y, Kim K, et al. (2024) A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control. Immunity |
| Fisch D, Zhang T, Sun H, et al. (2024) Molecular definition of the endogenous Toll-like receptor signalling pathways. Nature. 631: 635-644 |
| Landau LM, Chaudhary N, Tien YC, et al. (2024) pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism. Molecular Cell |
| Wu Z, Pope SD, Ahmed NS, et al. (2024) Control of Inflammatory Response by Tissue Microenvironment. Biorxiv : the Preprint Server For Biology |
| Jastrab JB, Kagan JC. (2024) Strategies of bacterial detection by inflammasomes. Cell Chemical Biology |
| Brown Harding H, Kwaku GN, Reardon CM, et al. (2024) Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING. Nature Microbiology |
| Cao LL, Kagan JC. (2023) Targeting innate immune pathways for cancer immunotherapy. Immunity |
| Landau LM, Kagan JC. (2023) Beyond natural biology: rewiring cellular networks to study innate immunity. Current Opinion in Immunology. 83: 102349 |
| Gauthier AE, Rotjan RD, Kagan JC. (2022) Lipopolysaccharide detection by the innate immune system may be an uncommon defence strategy used in nature. Open Biology. 12: 220146 |