Martijn Fenaux, Ph.D.

Affiliations: 
2004 Virginia Polytechnic Institute and State University, Blacksburg, VA, United States 
Area:
Veterinary Science Biology, Molecular Biology
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"Martijn Fenaux"

Parents

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Xiang-Jin Meng grad student 2004 Virginia Tech
 (Molecular pathogenesis and development of a genetically engineered vaccine for type-2 porcine circovirus.)
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Publications

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Kirschberg TA, Jones CT, Xu Y, et al. (2020) Selective Thyroid Hormone Receptor β Agonists with Oxadiazolone Acid Isosteres. Bioorganic & Medicinal Chemistry Letters. 127465
Romero FA, Jones C, Xu Y, et al. (2020) The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. Journal of Medicinal Chemistry
Feng JY, Wang T, Park Y, et al. (2018) Non-proteinogenic Amino Acid Containing Nucleotide Prodrug to Improve Oral Delivery of a Hepatitis C Virus Treatment. Antimicrobial Agents and Chemotherapy
Kirschberg TA, Mish MR, Zhang L, et al. (2015) Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 1040-3
Mish MR, Cho A, Kirschberg T, et al. (2014) Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 3092-5
Feng JY, Cheng G, Perry J, et al. (2014) Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrobial Agents and Chemotherapy. 58: 1930-42
Boyce SE, Tirunagari N, Niedziela-Majka A, et al. (2014) Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors. Plos One. 9: e84808
Lazerwith SE, Lew W, Zhang J, et al. (2014) Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection. Journal of Medicinal Chemistry. 57: 1893-901
Cho A, Zhang L, Xu J, et al. (2014) Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients. Journal of Medicinal Chemistry. 57: 1812-25
Fenaux M, Eng S, Leavitt SA, et al. (2013) Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase. Antimicrobial Agents and Chemotherapy. 57: 804-10
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