Kenneth B. Margulies - Publications

Affiliations: 
Bioengineering University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biomedical Engineering

240 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Selvaraj S, Patel S, Sauer AJ, McGarrah RW, Jones P, Kwee LC, Windsor SL, Ilkayeva O, Muehlbauer MJ, Newgard CB, Borlaug BA, Kitzman DW, Shah SJ, Margulies KB, Husain M, et al. Metabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction. Circulation. Heart Failure. e011980. PMID 39421941 DOI: 10.1161/CIRCHEARTFAILURE.124.011980  0.303
2024 Doan KV, Luongo TS, Ts'olo TT, Lee WD, Frederick DW, Mukherjee S, Adzika GK, Perry CE, Gaspar RB, Walker N, Blair MC, Bye N, Davis JG, Holman CD, Chu Q, ... ... Margulies KB, et al. Cardiac NAD depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics. Nature Cardiovascular Research. PMID 39294272 DOI: 10.1038/s44161-024-00542-9  0.302
2024 Lu F, Liou C, Ma Q, Wu Z, Xue B, Xia Y, Xia S, Trembley MA, Ponek A, Xie W, Shani K, Bortolin RH, Prondzynski M, Berkson P, Zhang X, ... ... Margulies KB, et al. Virally delivered CMYA5 enhances the assembly of cardiac dyads. Nature Biomedical Engineering. PMID 39237710 DOI: 10.1038/s41551-024-01253-z  0.334
2024 Tamayo I, Lee HJ, Aslam MI, Liu JJ, Ragi N, Karanam V, Maity S, Saliba A, Treviño E, Zheng H, Lim SC, Lanzer JD, Bjornstad P, Tuttle K, Bedi KC, ... Margulies KB, et al. Endogenous adenine is a potential driver of the cardiovascular-kidney-metabolic syndrome. Medrxiv : the Preprint Server For Health Sciences. PMID 39228698 DOI: 10.1101/2024.08.19.24312277  0.384
2024 Fayyaz AU, Eltony M, Prokop LJ, Koepp KE, Borlaug BA, Dasari S, Bois MC, Margulies KB, Maleszewski JJ, Wang Y, Redfield MM. Pathophysiological insights into HFpEF from studies of human cardiac tissue. Nature Reviews. Cardiology. PMID 39198624 DOI: 10.1038/s41569-024-01067-1  0.351
2024 Forelli N, Eaton D, Patel J, Bowman CE, Kawakami R, Kuznetsov IA, Li K, Brady C, Bedi K, Yang Y, Koya K, Megill E, Kanter DS, Smith LG, Bowman GR, ... ... Margulies K, et al. SGLT2 inhibitors activate pantothenate kinase in the human heart. Biorxiv : the Preprint Server For Biology. PMID 39091820 DOI: 10.1101/2024.07.26.605401  0.332
2024 Eaton DM, Lee BW, Caporizzo MA, Iyengar A, Chen CY, Uchida K, Marcellin G, Lannay Y, Vite A, Bedi KC, Brady CF, Smolyak JN, Meldrum D, Dominic J, Weingarten N, ... ... Margulies KB, et al. Vasohibin inhibition improves myocardial relaxation in a rat model of heart failure with preserved ejection fraction. Science Translational Medicine. 16: eadm8842. PMID 39018366 DOI: 10.1126/scitranslmed.adm8842  0.317
2023 Jani V, Aslam MI, Fenwick AJ, Ma W, Gong H, Milburn G, Nissen D, Salazar IC, Hanselman O, Mukherjee M, Halushka MK, Margulies KB, Campbell K, Irving TC, Kass DA, et al. Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure with Pulmonary Hypertension. Biorxiv : the Preprint Server For Biology. PMID 36945606 DOI: 10.1101/2023.03.09.531988  0.311
2023 Ozcan M, Guo Z, Valenzuela Ripoll C, Diab A, Picataggi A, Rawnsley D, Lotfinaghsh A, Bergom C, Szymanski J, Hwang D, Asnani A, Kosiborod M, Zheng J, Hayashi RJ, Woodard PK, ... ... Margulies KB, et al. Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity. Cell Metabolism. PMID 36868222 DOI: 10.1016/j.cmet.2023.02.006  0.342
2023 Hahn VS, Petucci C, Kim MS, Bedi KC, Wang H, Mishra S, Koleini N, Yoo EJ, Margulies KB, Arany Z, Kelly DP, Kass DA, Sharma K. Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction. Circulation. PMID 36856044 DOI: 10.1161/CIRCULATIONAHA.122.061846  0.351
2023 Simonson B, Chaffin M, Hill MC, Atwa O, Guedira Y, Bhasin H, Hall AW, Hayat S, Baumgart S, Bedi KC, Margulies KB, Klattenhoff CA, Ellinor PT. Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure. Cell Reports. 42: 112086. PMID 36790929 DOI: 10.1016/j.celrep.2023.112086  0.36
2023 Nollet EE, Duursma I, Rozenbaum A, Eggelbusch M, Wüst RCI, Schoonvelde SAC, Michels M, Jansen M, van der Wel NN, Bedi KC, Margulies KB, Nirschl J, Kuster DWD, van der Velden J. Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration. European Heart Journal. PMID 36734059 DOI: 10.1093/eurheartj/ehad028  0.689
2022 Flam E, Jang C, Murashige D, Yang Y, Morley MP, Jung S, Kantner DS, Pepper H, Bedi KC, Brandimarto J, Prosser BL, Cappola T, Snyder NW, Rabinowitz JD, Margulies KB, et al. Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy. Nature Cardiovascular Research. 1: 817-829. PMID 36776621 DOI: 10.1038/s44161-022-00117-6  0.31
2022 Levin MG, Tsao NL, Singhal P, Liu C, Vy HMT, Paranjpe I, Backman JD, Bellomo TR, Bone WP, Biddinger KJ, Hui Q, Dikilitas O, Satterfield BA, Yang Y, Morley MP, ... ... Margulies KB, et al. Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure. Nature Communications. 13: 6914. PMID 36376295 DOI: 10.1038/s41467-022-34216-6  0.348
2022 Murashige D, Jung JW, Neinast MD, Levin MG, Chu Q, Lambert JP, Garbincius JF, Kim B, Hoshino A, Marti-Pamies I, McDaid KS, Shewale SV, Flam E, Yang S, Roberts E, ... ... Margulies KB, et al. Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure. Cell Metabolism. PMID 36223763 DOI: 10.1016/j.cmet.2022.09.008  0.309
2022 Spurrell CH, Barozzi I, Kosicki M, Mannion BJ, Blow MJ, Fukuda-Yuzawa Y, Slaven N, Afzal SY, Akiyama JA, Afzal V, Tran S, Plajzer-Frick I, Novak CS, Kato M, Lee EA, ... ... Margulies KB, et al. Genome-wide fetalization of enhancer architecture in heart disease. Cell Reports. 40: 111400. PMID 36130500 DOI: 10.1016/j.celrep.2022.111400  0.336
2022 Margulies KB. DELIVERing Progress in Heart Failure with Preserved Ejection Fraction. The New England Journal of Medicine. PMID 36027566 DOI: 10.1056/NEJMe2210177  0.354
2022 Chaffin M, Papangeli I, Simonson B, Akkad AD, Hill MC, Arduini A, Fleming SJ, Melanson M, Hayat S, Kost-Alimova M, Atwa O, Ye J, Bedi KC, Nahrendorf M, Kaushik VK, ... ... Margulies KB, et al. Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy. Nature. PMID 35732739 DOI: 10.1038/s41586-022-04817-8  0.398
2022 Gibb AA, Murray EK, Huynh AT, Gaspar RB, Ploesch TL, Bedi K, Lombardi AA, Lorkiewicz PK, Roy R, Arany Z, Kelly DP, Margulies KB, Hill BG, Elrod JW. Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure. Circulation. 145: 1625-1628. PMID 35605036 DOI: 10.1161/CIRCULATIONAHA.121.057879  0.373
2022 Phyo SA, Uchida K, Chen CY, Caporizzo MA, Bedi K, Griffin J, Margulies K, Prosser BL. Transcriptional, Post-Transcriptional, and Post-Translational Mechanisms Rewrite the Tubulin Code During Cardiac Hypertrophy and Failure. Frontiers in Cell and Developmental Biology. 10: 837486. PMID 35433678 DOI: 10.3389/fcell.2022.837486  0.348
2021 Ma X, Rawnsley DR, Kovacs A, Islam M, Murphy JT, Zhao C, Kumari M, Foroughi L, Liu H, Qi K, Diwan A, Hyrc K, Evans S, Satoh T, French BA, ... Margulies KB, et al. TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis. Jacc. Basic to Translational Science. 7: 223-243. PMID 35411325 DOI: 10.1016/j.jacbts.2021.12.002  0.314
2021 Selvaraj S, Hu R, Vidula MK, Dugyala S, Tierney A, Ky B, Margulies KB, Shah SH, Kelly DP, Bravo PE. Acute Echocardiographic Effects of Exogenous Ketone Administration in Healthy Participants. Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography. PMID 34798244 DOI: 10.1016/j.echo.2021.10.017  0.381
2021 Mann DL, Givertz MM, Vader JM, Starling RC, Shah P, McNulty SE, Anstrom KJ, Margulies KB, Kiernan MS, Mahr C, Gupta D, Redfield MM, Lala A, Lewis GD, DeVore AD, et al. Effect of Treatment With Sacubitril/Valsartan in Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial. Jama Cardiology. PMID 34730769 DOI: 10.1001/jamacardio.2021.4567  0.328
2021 Lumbers RT, Shah S, Lin H, Czuba T, Henry A, Swerdlow DI, Mälarstig A, Andersson C, Verweij N, Holmes MV, Ärnlöv J, Svensson P, Hemingway H, Sallah N, Almgren P, ... ... Margulies KB, et al. The genomics of heart failure: design and rationale of the HERMES consortium. Esc Heart Failure. PMID 34480422 DOI: 10.1002/ehf2.13517  0.317
2021 Sharma A, Greene S, Vaduganathan M, Fudim M, Ambrosy AP, Sun JL, McNulty SE, Hernandez AF, Borlaug BA, Velazquez EJ, Mentz RJ, DeVore AD, Alhanti B, Margulies K, Felker GM. Growth differentiation factor-15, treatment with liraglutide, and clinical outcomes among patients with heart failure. Esc Heart Failure. PMID 34061470 DOI: 10.1002/ehf2.13348  0.334
2021 Zamani P, Proto EA, Wilson N, Fazelinia H, Ding H, Spruce LA, Davila A, Hanff TC, Mazurek JA, Prenner SB, Desjardins B, Margulies KB, Kelly DP, Arany Z, Doulias PT, et al. Multimodality assessment of heart failure with preserved ejection fraction skeletal muscle reveals differences in the machinery of energy fuel metabolism. Esc Heart Failure. PMID 33991175 DOI: 10.1002/ehf2.13329  0.517
2021 Yang N, Parker L, Yu J, Jones JW, Liu T, Papanicolaou KN, Talbot CC, Margulies KB, O'Rourke B, Kane M, Foster DB. Cardiac retinoic acid levels decline in heart failure. Jci Insight. PMID 33724958 DOI: 10.1172/jci.insight.137593  0.379
2021 Liu CF, Ni Y, Moravec CS, Morley M, Ashley EA, Cappola TP, Margulies KB, Tang WHW. Whole-Transcriptome Profiling of Human Heart Tissues Reveals the Potential Novel Players and Regulatory Networks in Different Cardiomyopathy Subtypes of Heart Failure. Circulation. Genomic and Precision Medicine. CIRCGEN120003142. PMID 33517678 DOI: 10.1161/CIRCGEN.120.003142  0.35
2020 Selvaraj S, Margulies KB. Exogenous Ketones In The Healthy Heart: The Plot Thickens. Cardiovascular Research. PMID 33070197 DOI: 10.1093/cvr/cvaa283  0.362
2020 Anene-Nzelu CG, Tan WLW, Lee CJM, Wenhao Z, Perrin A, Dashi A, Tiang Z, Autio MI, Lim B, Wong E, Tan HS, Pan B, Morley MP, Margulies KB, Cappola TP, et al. Assigning Distal Genomic Enhancers to Cardiac Disease-Causing Genes. Circulation. 142: 910-912. PMID 32866060 DOI: 10.1161/Circulationaha.120.046040  0.314
2020 Wilcox JE, Fang JC, Margulies KB, Mann DL. Heart Failure With Recovered Left Ventricular Ejection Fraction: JACC Scientific Expert Panel. Journal of the American College of Cardiology. 76: 719-734. PMID 32762907 DOI: 10.1016/J.Jacc.2020.05.075  0.454
2020 Zhang X, Li Y, Zhang X, Piacentino V, Harris DM, Berretta R, Margulies KB, Houser SR, Chen X. A low voltage activated Ca current found in a subset of human ventricular myocytes. Channels (Austin, Tex.). 14: 231-245. PMID 32684070 DOI: 10.1080/19336950.2020.1794420  0.446
2020 Tan WLW, Anene-Nzelu CG, Wong E, Lee M, Tan HS, Tang SJ, Perrin AMY, Wu KX, Zheng WH, Ashburn RJ, Pan B, Lee MY, Autio MI, Morley M, Tam WL, ... ... Margulies KB, et al. Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype. Circulation Research. PMID 32529949 DOI: 10.1161/Circresaha.120.317254  0.439
2020 Selvaraj S, Kelly DP, Margulies KB. Implications of Altered Ketone Metabolism and Therapeutic Ketosis in Heart Failure. Circulation. 141: 1800-1812. PMID 32479196 DOI: 10.1161/Circulationaha.119.045033  0.438
2020 Tucker NR, Chaffin M, Fleming SJ, Hall AW, Parsons VA, Bedi KC, Akkad AD, Herndon CN, Arduini A, Papangeli I, Roselli C, Aguet F, Choi SH, Ardlie KG, Babadi M, ... Margulies KB, et al. Transcriptional and Cellular Diversity of the Human Heart. Circulation. PMID 32403949 DOI: 10.1161/Circulationaha.119.045401  0.333
2020 Redouane B, Greene SJ, Fudim M, Vaduganathan M, Ambrosy AP, Sun JL, DeVore AD, McNulty SE, Mentz RJ, Hernandez AF, Felker GM, Cooper LB, Borlaug BA, Velazquez EJ, Margulies KB, et al. Effects of Liraglutide on Worsening Renal Function Among Patients With Heart Failure With Reduced Ejection Fraction: Insights From the FIGHT Trial. Circulation. Heart Failure. 13: e006758. PMID 32362166 DOI: 10.1161/CIRCHEARTFAILURE.119.006758  0.321
2020 Chen CY, Salomon AK, Caporizzo MA, Curry S, Kelly NA, Bedi KC, Bogush AI, Krämer E, Schlossarek S, Janiak P, Moutin MJ, Carrier L, Margulies KB, Prosser BL. Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes. Circulation Research. PMID 32272864 DOI: 10.1161/Circresaha.119.315947  0.31
2020 Caporizzo MA, Chen CY, Bedi K, Margulies KB, Prosser BL. Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium. Circulation. PMID 31941365 DOI: 10.1161/Circulationaha.119.043930  0.318
2020 Shah S, Henry A, Roselli C, Lin H, Sveinbjörnsson G, Fatemifar G, Hedman ÅK, Wilk JB, Morley MP, Chaffin MD, Helgadottir A, Verweij N, Dehghan A, Almgren P, Andersson C, ... ... Margulies KB, et al. Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Nature Communications. 11: 163. PMID 31919418 DOI: 10.1038/S41467-019-13690-5  0.307
2019 Nassif ME, Windsor S, Tang F, Khariton Y, Husain M, Inzucchi SE, McGuire D, Pitt B, Scirica BM, Austin B, Drazner M, Fong M, Givertz MM, Gordon R, Jermyn R, ... ... Margulies KB, et al. Dapagliflozin Effects on Biomarkers, Symptoms, and Functional Status in Patients With Heart Failure With Reduced Ejection Fraction: The DEFINE-HF Trial. Circulation. PMID 31524498 DOI: 10.1161/Circulationaha.119.042929  0.404
2019 Aghajanian H, Kimura T, Rurik JG, Hancock AS, Leibowitz MS, Li L, Scholler J, Monslow J, Lo A, Han W, Wang T, Bedi K, Morley MP, Linares Saldana RA, Bolar NA, ... ... Margulies KB, et al. Targeting cardiac fibrosis with engineered T cells. Nature. PMID 31511695 DOI: 10.1038/S41586-019-1546-Z  0.438
2019 Ma Y, Su KN, Pfau D, Rao VS, Wu X, Hu X, Leng L, Du X, Piecychna M, Bedi K, Campbell SG, Eichmann A, Testani JM, Margulies KB, Bucala R, et al. Cardiomyocyte d-dopachrome tautomerase protects against heart failure. Jci Insight. 4. PMID 31484822 DOI: 10.1172/Jci.Insight.128900  0.494
2019 Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J, Bedi KC, Margulies KB, Sanz-Moreno V, Hobbs A, Hodivala-Dilke K. Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease. The Journal of Pathology. PMID 31424556 DOI: 10.1002/Path.5340  0.473
2019 Cordero P, Parikh VN, Chin ET, Erbilgin A, Gloudemans MJ, Shang C, Huang Y, Chang AC, Smith KS, Dewey F, Zaleta K, Morley M, Brandimarto J, Glazer N, Waggott D, ... ... Margulies KB, et al. Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure. Nature Communications. 10: 2760. PMID 31235787 DOI: 10.1038/S41467-019-10591-5  0.338
2019 Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS, Hobbs AJ. C-type natriuretic peptide co-ordinates cardiac structure and function. European Heart Journal. PMID 30903134 DOI: 10.1093/Eurheartj/Ehz093  0.378
2019 Xiong Y, Bedi KC, Berritt S, Brooks TG, Attipoe BK, Wang K, Margulies KB, Field J. Targeting MRTF/SRF in CAP2-dependent dilated cardiomyopathy delays disease onset. Jci Insight. PMID 30762586 DOI: 10.1172/Jci.Insight.124629  0.403
2019 Ma Y, Hu X, Wu X, Pfau D, Leng L, Bedi K, Margulies K, Bucala R, Young L. Abstract 875: Cardiomyocyte Derived DDT Protects Against Myocardial Infarction Induced Heart Failure Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.875  0.467
2019 Flam E, Jang C, Bedi K, Margulies K, Arany Z. Abstract 850: Metabolic Landscape of Human Heart Failure Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.850  0.422
2019 Livingston C, Ramachandran A, Corbin E, Vite A, Bennett A, Margulies KB. Abstract 756: Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model With Dynamically Tunable Afterload Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.756  0.32
2019 Caporizzo MA, Chen CY, Bedi K, Margulies KB, Prosser BL. Abstract 613: Isolating the Pathological Contribution of Detyrosinated Microtubules in Human Myocardial Mechanics Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.613  0.312
2019 Gibb AA, Lombardi AA, Murray EK, Tan Y, Lorkiewicz PK, Huynh AT, Kolmetzky DW, Arany Z, Kelly DP, Margulies KB, Hill BG, Elrod JW. Abstract 517: Glutaminolysis is Required to Initiate Myofibroblast Differentiation and Persistence During Stress Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.517  0.433
2019 Nzelu CGA, Tan W, Wong E, Lee M, Autio MI, Tan S, Bangfen P, Morley M, Margulies K, Cappola T, Loh M, Chambers J, Prabhakar S, Foo R. Abstract 368: Disease and Phenotype-relevant Genetic Variants Identified From Histone Acetylomes in Human Hearts Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.368  0.347
2019 McAfee Q, Brandimarto J, Rhoades J, Bede K, Margulies K, Arany Z. Abstract 335: Titin Truncations in Human Heart Tissue Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.335  0.404
2019 Bedi KC, Motta CC, Fink MJ, Nicklas T, Margulies KB. Effects of Orthostatic Position in Point of Care Lung Ultrasound in Acute Decompensated Heart Failure; a Potential for Simple Interventions Journal of Cardiac Failure. 25. DOI: 10.1016/J.Cardfail.2019.07.383  0.365
2019 Vite A, Bedi K, Margulies K. Effect of Substrate on Adult Human Cardiomyocytes Contractility Journal of Cardiac Failure. 25: S113. DOI: 10.1016/J.Cardfail.2019.07.322  0.42
2019 Troutman GS, Grandin EW, Birati EY, Zamani PL, Pedrotty DM, Chirinos JA, Margulies KB, Atluri P, Rame JE, Mazurek JA, Fox A. Doppler-Derived Pulmonary Arterial Compliance (PAC) Correlates with Invasively Measured PAC in Patients with Advanced Heart Failure and Reduced Ejection Fraction Journal of Cardiac Failure. 25. DOI: 10.1016/J.Cardfail.2019.07.187  0.393
2019 Ramirez GL, Nicklas T, Fink M, Margulies K. Potential Markers of Sacubitril-Valsartan Tolerance Journal of Cardiac Failure. 25. DOI: 10.1016/J.Cardfail.2019.07.175  0.317
2019 Ramachandran A, Livingston C, Corbin E, Vite A, Bennett A, Margulies KB. Cardiac Microtissue Platform with Dynamically Tunable Afterload Control to Show Contractile Reserve and Pathologic Hypertrophy Journal of Cardiac Failure. 25: S34. DOI: 10.1016/J.Cardfail.2019.07.093  0.391
2019 Aslam MI, Lin B, Bedi K, Margulies KB, Kass DA, Hsu S. Right Ventricular Sarcomere Dysfunction Underlies Right-Sided Hemodynamic Decompensation in Pulmonary Hypertension Secondary to End-Stage Human Heart Failure Journal of Cardiac Failure. 25. DOI: 10.1016/J.Cardfail.2019.07.014  0.405
2019 Caporizzo MA, Chen CY, Bedi K, Margulies KB, Prosser BL. Isolating the Pathological Contribution of Detyrosinated Microtubules in Human Myocardial Mechanics Biophysical Journal. 116: 264a. DOI: 10.1016/J.Bpj.2018.11.1435  0.314
2018 Borlaug BA, Anstrom KJ, Lewis GD, Shah SJ, Levine JA, Koepp GA, Givertz MM, Felker GM, LeWinter MM, Mann DL, Margulies KB, Smith AL, Tang WHW, Whellan DJ, Chen HH, et al. Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial. Jama. 320: 1764-1773. PMID 30398602 DOI: 10.1001/Jama.2018.14852  0.421
2018 Wang Y, Chen B, Huang CK, Guo A, Wu J, Zhang X, Chen R, Chen C, Kutschke W, Weiss RM, Boudreau RL, Margulies KB, Hong J, Song LS. Targeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models. Jacc. Basic to Translational Science. 3: 503-517. PMID 30175274 DOI: 10.1016/J.Jacbts.2018.05.004  0.484
2018 Sharma A, Ambrosy AP, DeVore AD, Margulies KB, McNulty SE, Mentz RJ, Hernandez AF, Michael Felker G, Cooper LB, Lala A, Vader J, Groake JD, Borlaug BA, Velazquez EJ. Liraglutide and weight loss among patients with advanced heart failure and a reduced ejection fraction: insights from the FIGHT trial. Esc Heart Failure. PMID 30120812 DOI: 10.1002/ehf2.12334  0.364
2018 Truitt R, Mu A, Corbin EA, Vite A, Brandimarto J, Ky B, Margulies KB. Increased Afterload Augments Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model. Jacc. Basic to Translational Science. 3: 265-276. PMID 30062212 DOI: 10.1016/J.Jacbts.2017.12.007  0.387
2018 Chen CY, Caporizzo MA, Bedi K, Vite A, Bogush AI, Robison P, Heffler JG, Salomon AK, Kelly NA, Babu A, Morley MP, Margulies KB, Prosser BL. Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nature Medicine. PMID 29892068 DOI: 10.1038/S41591-018-0046-2  0.472
2018 Nirschl JJ, Janowczyk A, Peyster EG, Frank R, Margulies KB, Feldman MD, Madabhushi A. A deep-learning classifier identifies patients with clinical heart failure using whole-slide images of H&E tissue. Plos One. 13: e0192726. PMID 29614076 DOI: 10.1371/Journal.Pone.0192726  0.764
2018 Peyster EG, Madabhushi A, Margulies KB. Advanced Morphologic Analysis for Diagnosing Allograft Rejection: The Case of Cardiac Transplant Rejection. Transplantation. PMID 29570167 DOI: 10.1097/Tp.0000000000002189  0.302
2018 Kiernan MS, Stevens SR, Tang WHW, Butler J, Anstrom KJ, Birati EY, Grodin JL, Gupta D, Margulies KB, LaRue S, Dávila-Román VG, Hernandez AF, de Las Fuentes L. Determinants of Diuretic Responsiveness and Associated Outcomes during Acute Heart Failure Hospitalization: an Analysis From the NHLBI Heart Failure Network Clinical Trials. Journal of Cardiac Failure. PMID 29482026 DOI: 10.1016/J.Cardfail.2018.02.002  0.402
2018 Zhang X, Yoon JY, Morley M, McLendon JM, Mapuskar KA, Gutmann R, Mehdi H, Bloom HL, Dudley SC, Ellinor PT, Shalaby AA, Weiss R, Tang WHW, Moravec CS, Singh M, ... ... Margulies KB, et al. A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality. The Journal of Clinical Investigation. PMID 29457789 DOI: 10.1172/Jci95710  0.379
2018 Baggio LL, Yusta B, Mulvihill EE, Cao X, Streutker CJ, Butany J, Cappola TP, Margulies KB, Drucker DJ. GLP-1 receptor expression within the human heart. Endocrinology. PMID 29444223 DOI: 10.1210/En.2018-00004  0.373
2018 Hsu S, Kokkonen-Simon KM, Kirk JA, Kolb TM, Damico RL, Mathai SC, Mukherjee M, Shah AA, Wigley FM, Margulies KB, Hassoun PM, Halushka MK, Tedford RJ, Kass DA. Right Ventricular Myofilament Functional Differences in Humans with Systemic Sclerosis-associated versus Idiopathic Pulmonary Arterial Hypertension. Circulation. PMID 29352073 DOI: 10.1161/Circulationaha.117.033147  0.338
2018 Birks E, Drakos S, Lowes B, Patel S, Selzman C, Slaughter M, Alturi P, Goldstein D, Um J, Cunningham C, Margulies K, Stehlik J, Starling R, Farrar D, Rame E. Outcome and Primary Endpoint Results From a Prospective Multi-center Study of Myocardial Recovery Using LVADs: Remission from Stage D Heart Failure (RESTAGE-HF) The Journal of Heart and Lung Transplantation. 37: S142. DOI: 10.1016/J.Healun.2018.01.342  0.413
2018 Yingxian Chen C, Caporizzo MA, Bedi K, Morley MP, Margulies KB, Prosser BL. Suppressing Detyrosinated Microtubules Improves My-Cute Function in Human Heart Failure Biophysical Journal. 114: 139a. DOI: 10.1016/J.Bpj.2017.11.786  0.439
2018 Robison P, Yingxian Chen C, Caporizzo MA, Bedi K, Margulies KB, Prosser BL. Ultrastructural Surveys of Cardiomyocytes Isolated from Failing Human Hearts Biophysical Journal. 114: 497a-498a. DOI: 10.1016/J.Bpj.2017.11.2724  0.429
2017 Zhao SD, Cai TT, Cappola TP, Margulies KB, Li H. Sparse simultaneous signal detection for identifying genetically controlled disease genes. Journal of the American Statistical Association. 112: 1032-1046. PMID 29375169 DOI: 10.1080/01621459.2016.1270825  0.303
2017 LeWinter MM, Taatjes D, Ashikaga T, Palmer B, Bishop N, VanBuren P, Bell S, Donaldson C, Meyer M, Margulies KB, Redfield M, Bull DA, Zile M. Abundance, localization, and functional correlates of the advanced glycation end-product carboxymethyl lysine in human myocardium. Physiological Reports. 5. PMID 29066596 DOI: 10.14814/Phy2.13462  0.334
2017 Gopal DJ, Hanff TC, Mazurek JA, Grandin WE, Howard J, Forde-McLean R, Wald J, King K, Acker MA, Goldberg LR, Jessup M, Atluri P, Margulies KB, Rame EJ, Birati EY. Prognostic Implications of Changes in Albumin Following Left Ventricular Assist Device Implantation in Patients With Severe Heart Failure. The American Journal of Cardiology. PMID 28947307 DOI: 10.1016/J.Amjcard.2017.08.005  0.32
2017 Sharifi-Sanjani M, Oyster NM, Tichy ED, Bedi KC, Harel O, Margulies KB, Mourkioti F. Cardiomyocyte-Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans. Journal of the American Heart Association. 6. PMID 28882819 DOI: 10.1161/Jaha.116.005086  0.469
2017 Butler J, Anstrom KJ, Felker GM, Givertz MM, Kalogeropoulos AP, Konstam MA, Mann DL, Margulies KB, McNulty SE, Mentz RJ, Redfield MM, Tang WHW, Whellan DJ, Shah M, Desvigne-Nickens P, et al. Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial. Jama Cardiology. PMID 28700781 DOI: 10.1001/Jamacardio.2017.2198  0.404
2017 Chirinos JA, Londono-Hoyos F, Zamani P, Beraun M, Haines P, Vasim I, Varakantam S, Phan TS, Cappola TP, Margulies KB, Townsend RR, Segers P. Effects of organic and inorganic nitrate on aortic and carotid haemodynamics in heart failure with preserved ejection fraction. European Journal of Heart Failure. PMID 28547861 DOI: 10.1002/Ejhf.885  0.43
2017 Chen CW, Sprys MH, Gaffey AC, Chung JJ, Margulies KB, Acker MA, Atluri P. Low ejection fraction in donor hearts is not directly associated with increased recipient mortality. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. PMID 28314504 DOI: 10.1016/J.Healun.2017.02.001  0.401
2017 Vikram A, Lewarchik CM, Yoon JY, Naqvi A, Kumar S, Morgan GM, Jacobs JS, Li Q, Kim YR, Kassan M, Liu J, Gabani M, Kumar A, Mehdi H, Zhu X, ... ... Margulies KB, et al. Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel. Nature Medicine. PMID 28191886 DOI: 10.1038/Nm.4284  0.375
2017 Rowe GC, Asimaki A, Graham EL, Martin KD, Margulies KB, Das S, Saffitz JE, Arany Z. Development of Dilated Cardiomyopathy and Impaired Calcium Homeostasis with Cardiac-Specific Deletion of ESRRβ. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00446.2016. PMID 28130335 DOI: 10.1152/Ajpheart.00446.2016  0.417
2017 Narayan HK, Finkelman BS, French B, Plappert T, Hyman D, Smith AM, Margulies KB, Ky B. Detailed Echocardiographic Phenotyping in Breast Cancer Patients: Associations with Ejection Fraction Decline, Recovery, and Heart Failure Symptoms over 3 Years of Followup. Circulation. PMID 28104715 DOI: 10.1161/Circulationaha.116.023463  0.431
2017 Seigerman M, Molina M, Hanff T, Mazurek J, Padegimas A, Menachem J, Wald J, Rame JE, Horsnby N, Acker M, Atluri P, Bermudez C, Margulies K, Jessup M, Forde-Mclean R, et al. Short and Long Term Outcomes of Combined Heart and Kidney Transplantation: A Single-Center Experience Journal of Cardiac Failure. 23: S130. DOI: 10.1016/J.Cardfail.2017.07.383  0.308
2016 Margulies KB, McNulty SE, Cappola TP. Lack of Benefit for Liraglutide in Heart Failure-Reply. Jama. 316: 2429-2430. PMID 27959992 DOI: 10.1001/Jama.2016.15394  0.455
2016 Zamani P, Tan VX, Soto-Calderon H, Beraun M, Brandimarto J, Trieu L, Varakantam S, Doulias PT, Townsend RR, Chittams J, Margulies KB, Cappola TP, Poole DC, Ischiropoulos H, Chirinos JA. Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction. Circulation Research. PMID 27927683 DOI: 10.1161/Circresaha.116.309832  0.449
2016 Butler J, Epstein SE, Greene SJ, Quyyumi AA, Sikora S, Kim RJ, Anderson AS, Wilcox JE, Tankovich NI, Lipinski MJ, Ko YA, Margulies KB, Cole RT, Skopicki HA, Gheorghiade M. Intravenous Allogeneic Mesenchymal Stem Cells for Non-Ischemic Cardiomyopathy: Safety and Efficacy Results of a Phase II-A Randomized Trial. Circulation Research. PMID 27856497 DOI: 10.1161/Circresaha.116.309717  0.354
2016 Chirinos JA, Akers SR, Trieu L, Ischiropoulos H, Doulias PT, Tariq A, Vassim I, Koppula MR, Syed AA, Soto-Calderon H, Townsend RR, Cappola TP, Margulies KB, Zamani P. Heart Failure, Left Ventricular Remodeling, and Circulating Nitric Oxide Metabolites. Journal of the American Heart Association. 5. PMID 27742619 DOI: 10.1161/Jaha.116.004133  0.337
2016 Zamani P, French B, Brandimarto JA, Doulias PT, Javaheri A, Chirinos JA, Margulies KB, Townsend RR, Sweitzer NK, Fang JC, Ischiropoulos H, Cappola TP. Effect of Heart Failure With Preserved Ejection Fraction on Nitric Oxide Metabolites. The American Journal of Cardiology. PMID 27742422 DOI: 10.1016/J.Amjcard.2016.08.077  0.394
2016 Margulies KB, Hernandez AF, Redfield MM, Givertz MM, Oliveira GH, Cole R, Mann DL, Whellan DJ, Kiernan MS, Felker GM, McNulty SE, Anstrom KJ, Shah MR, Braunwald E, Cappola TP, et al. Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial. Jama. 316: 500-508. PMID 27483064 DOI: 10.1001/Jama.2016.10260  0.466
2016 Grandin EW, Zamani P, Mazurek JA, Troutman GS, Birati EY, Vorovich E, Chirinos JA, Tedford RJ, Margulies KB, Atluri P, Rame JE. Right ventricular response to pulsatile load is associated with early right heart failure and mortality after left ventricular assist device. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. PMID 27469015 DOI: 10.1016/J.Healun.2016.06.015  0.38
2016 Liu M, Verma N, Peng X, Srodulski S, Morris A, Chow M, Hersh LB, Chen J, Zhu H, Netea MG, Margulies KB, Despa S, Despa F. Hyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury. Diabetes. PMID 27335231 DOI: 10.2337/Db16-0044  0.341
2016 Hou N, Ye B, Li X, Margulies KB, Xu H, Wang X, Li F. Transcription Factor 7-like 2 Mediates Canonical Wnt/β-Catenin Signaling and c-Myc Upregulation in Heart Failure. Circulation. Heart Failure. 9. PMID 27301468 DOI: 10.1161/CIRCHEARTFAILURE.116.003010 e003010  0.407
2016 Margulies KB. Evolving Challenges for Targeting Metabolic Abnormalities in Heart Failure. Jacc. Heart Failure. PMID 27179826 DOI: 10.1016/J.Jchf.2016.03.008  0.416
2016 Smith JG, Felix JF, Morrison AC, Kalogeropoulos A, Trompet S, Wilk JB, Gidlöf O, Wang X, Morley M, Mendelson M, Joehanes R, Ligthart S, Shan X, Bis JC, Wang YA, ... ... Margulies KB, et al. Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure. Plos Genetics. 12: e1006034. PMID 27149122 DOI: 10.1371/Journal.Pgen.1006034  0.306
2016 Horton JL, Martin OJ, Lai L, Riley NM, Richards AL, Vega RB, Leone TC, Pagliarini DJ, Muoio DM, Bedi KC, Margulies KB, Coon JJ, Kelly DP. Mitochondrial protein hyperacetylation in the failing heart. Jci Insight. 2. PMID 26998524 DOI: 10.1172/Jci.Insight.84897  0.442
2016 Birati EY, Mathelier H, Molina M, Hanff TC, Mazurek JA, Atluri P, Acker MA, Rame JE, Margulies KB, Goldberg LR, Jessup M. Comparison of Causes of Death After Heart Transplantation in Patients With Left Ventricular Ejection Fractions ≤35% Versus >35. The American Journal of Cardiology. PMID 26899490 DOI: 10.1016/J.Amjcard.2016.01.028  0.337
2016 Bedi KC, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth A, Wang L, Javaheri A, Blair IA, Margulies K, Rame JE. Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure. Circulation. PMID 26819374 DOI: 10.1161/Circulationaha.115.017545  0.323
2016 Grandin EW, Gulati AA, Troutman GS, Zamani P, Mazurek JA, Birati EY, Wald JW, Margulies KB, Atluri P, Rame JE. Mitral Regurgitation Is Associated with Right Ventricular Pulsatile Loading and Early Right Heart Failure After Left Ventricular Assist Device Journal of Heart and Lung Transplantation. 35. DOI: 10.1016/J.Healun.2016.01.455  0.411
2016 Chen C, Gaffey A, Sprys M, Chung J, Margulies K, Acker M, Atluri P. Low Ejection Fraction in Young Donor Hearts Is Not Associated with Increased Recipient Mortality The Journal of Heart and Lung Transplantation. 35: S58. DOI: 10.1016/J.Healun.2016.01.160  0.375
2016 Telukuntla K, Hanff T, Grandin E, Mazurek J, Howard J, Wald J, Goldberg L, Jessup M, Acker M, Margulies K, Atluri P, Rame J, Birati E. Changes in Lipid Profile Following Durable Mechanical Circulatory Support: Confirming the “Lipid Paradox” in Heart Failure The Journal of Heart and Lung Transplantation. 35: S387-S388. DOI: 10.1016/J.Healun.2016.01.1117  0.418
2016 Grandin E, Troutman G, Gulati A, Zamani P, Mazurek J, Birati E, Wald J, Margulies K, Atluri P, Rame J. Clinical Outcomes Reveal a Spectrum of Early Right Heart Failure after Left Ventricular Assist Device The Journal of Heart and Lung Transplantation. 35: S10. DOI: 10.1016/J.Healun.2016.01.028  0.409
2016 Javaheri A, Shewale S, Frej C, Liu M, Bedi K, Brandimarto J, Mu A, Wang T, Chen CY, Ma X, Zamani P, French B, Margulies KB, Cappola TP, Prosser BL, et al. Apolipoprotein M Improves Survival in Congestive Heart Failure via Enhanced Akt Signaling Journal of Cardiac Failure. 22: S1. DOI: 10.1016/J.Cardfail.2016.06.016  0.392
2015 Chirico EN, Ding D, Muthukumaran G, Houser SR, Starosta T, Mu A, Margulies KB, Libonati JR. Acute aerobic exercise increases exogenously infused bone marrow cell retention in the heart. Physiological Reports. 3. PMID 26486160 DOI: 10.14814/Phy2.12566  0.358
2015 Borlaug BA, Chen H, Lin G, Redfield MM, Lewis GD, Semigran MJ, McNulty SE, LeWinter M, Deswal A, Margulies KB. Response to Letter Regarding Article, “Effects of Sildenafil on Ventricular and Vascular Function in Heart Failure With Preserved Ejection Fraction”. Circulation. Heart Failure. 8: 840. PMID 26405727 DOI: 10.1161/Circheartfailure.115.002372  0.468
2015 Lambert R, Srodulski S, Peng X, Margulies KB, Despa F, Despa S. Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport. Journal of the American Heart Association. 4. PMID 26316524 DOI: 10.1161/Jaha.115.002183  0.331
2015 Grodin JL, Stevens SR, Lisa LF, Kiernan M, Birati EY, Gupta D, Bart BA, Felker GM, Chen HH, Butler J, Dávila-Román VG, Margulies KB, Hernandez AF, Anstrom KJ, Tang WH. Intensification of Medication Therapy for Cardiorenal Syndrome in Acute Decompensated Heart Failure. Journal of Cardiac Failure. PMID 26209004 DOI: 10.1016/J.Cardfail.2015.07.007  0.449
2015 Givertz MM, Anstrom KJ, Redfield MM, Deswal A, Haddad H, Butler J, Tang WH, Dunlap ME, LeWinter MM, Mann DL, Felker GM, O'Connor CM, Goldsmith SR, Ofili EO, Saltzberg MT, ... Margulies KB, et al. Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study. Circulation. 131: 1763-71. PMID 25986447 DOI: 10.1161/Circulationaha.114.014536  0.434
2015 Herren AW, Weber DM, Rigor RR, Margulies KB, Phinney BS, Bers DM. CaMKII Phosphorylation of NaV1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure. Journal of Proteome Research. 14: 2298-311. PMID 25815641 DOI: 10.1021/Acs.Jproteome.5B00107  0.36
2015 Lee DI, Zhu G, Sasaki T, Cho GS, Hamdani N, Holewinski R, Jo SH, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Kwon C, ... Margulies KB, et al. Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Nature. 519: 472-6. PMID 25799991 DOI: 10.1038/Nature14332  0.367
2015 Borlaug BA, Lewis GD, McNulty SE, Semigran MJ, LeWinter M, Chen H, Lin G, Deswal A, Margulies KB, Redfield MM. Effects of sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction. Circulation. Heart Failure. 8: 533-41. PMID 25782985 DOI: 10.1161/Circheartfailure.114.001915  0.451
2015 Masterson Creber RM, Lee CS, Margulies K, Riegel B. Identifying biomarker patterns and predictors of inflammation and myocardial stress. Journal of Cardiac Failure. 21: 439-45. PMID 25727486 DOI: 10.1016/J.Cardfail.2015.02.006  0.347
2015 Zamani P, Rawat D, Shiva-Kumar P, Geraci S, Bhuva R, Konda P, Doulias PT, Ischiropoulos H, Townsend RR, Margulies KB, Cappola TP, Poole DC, Chirinos JA. Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction. Circulation. 131: 371-80; discussion 3. PMID 25533966 DOI: 10.1161/Circulationaha.114.012957  0.367
2015 Liu Y, Morley M, Brandimarto J, Hannenhalli S, Hu Y, Ashley EA, Tang WH, Moravec CS, Margulies KB, Cappola TP, Li M. RNA-Seq identifies novel myocardial gene expression signatures of heart failure. Genomics. 105: 83-9. PMID 25528681 DOI: 10.1016/J.Ygeno.2014.12.002  0.417
2015 Borlaug BA, Chen H, Lin G, Redfield MM, Lewis GD, Semigran MJ, McNulty SE, LeWinter M, Deswal A, Margulies KB. Response to letter regarding article, Effects of Sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction Circulation: Heart Failure. 8: 840. DOI: 10.1161/CIRCHEARTFAILURE.115.002372  0.342
2015 Grandin E, Mazurek J, Zamani P, Troutman G, Vorovich E, Birati E, Banerji S, Pedrotty D, Kirkpatrick J, Margulies K, Atluri P, Rame J. Decreased Pulmonary Artery Compliance Is Associated With Right Heart Failure and Reduced 6-Month Survival After Left Ventricular Assist Device The Journal of Heart and Lung Transplantation. 34: S209. DOI: 10.1016/J.Healun.2015.01.575  0.39
2015 Rame J, Bedi K, Snyder N, Brandimarto J, Mesaros C, Birati E, Blair I, Margulies K. Myocardial Lipid Metabolism in the End-Stage Failing: Heart: Evidence for an Energy-Starved State The Journal of Heart and Lung Transplantation. 34: S89-S90. DOI: 10.1016/J.Healun.2015.01.239  0.347
2014 Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F. Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. Journal of the American Heart Association. 3. PMID 25146704 DOI: 10.1161/Jaha.114.001015  0.418
2014 Fargnoli AS, Katz MG, Williams RD, Walling TL, Margulies KB, Bridges CR. An Innovative Needleless Liquid Jet Injection Delivery Method for Heart Failure Gene Therapy: Preliminary Study Featuring AAV9 Demonstrates Greater Cardiac Specificity Versus Standard Approaches Journal of Cardiac Failure. 20. PMID 25106956 DOI: 10.1016/J.Cardfail.2014.06.009  0.416
2014 Alvarez RM, Margulies KB. Epigenetic memory and cardiac cell therapy. Journal of the American College of Cardiology. 64: 449-50. PMID 25082576 DOI: 10.1016/J.Jacc.2014.05.021  0.474
2014 Margulies KB, Anstrom KJ, Hernandez AF, Redfield MM, Shah MR, Braunwald E, Cappola TP. GLP-1 agonist therapy for advanced heart failure with reduced ejection fraction: design and rationale for the functional impact of GLP-1 for heart failure treatment study. Circulation. Heart Failure. 7: 673-9. PMID 25028349 DOI: 10.1161/Circheartfailure.114.000346  0.378
2014 Cohen JE, Purcell BP, MacArthur JW, Mu A, Shudo Y, Patel JB, Brusalis CM, Trubelja A, Fairman AS, Edwards BB, Davis MS, Hung G, Hiesinger W, Atluri P, Margulies KB, et al. A bioengineered hydrogel system enables targeted and sustained intramyocardial delivery of neuregulin, activating the cardiomyocyte cell cycle and enhancing ventricular function in a murine model of ischemic cardiomyopathy. Circulation. Heart Failure. 7: 619-26. PMID 24902740 DOI: 10.1161/Circheartfailure.113.001273  0.302
2014 Birati EY, Kirkpatrick JN, Rame JE, Bala R, Margulies KB. Dynamic left ventricular assist device inflow obstruction. Circulation. Heart Failure. 7: 225-6. PMID 24449814 DOI: 10.1161/Circheartfailure.113.000941  0.395
2013 Chen HH, Anstrom KJ, Givertz MM, Stevenson LW, Semigran MJ, Goldsmith SR, Bart BA, Bull DA, Stehlik J, LeWinter MM, Konstam MA, Huggins GS, Rouleau JL, O'Meara E, Tang WH, ... ... Margulies KB, et al. Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. Jama. 310: 2533-43. PMID 24247300 DOI: 10.1001/Jama.2013.282190  0.369
2013 Anand P, Brown JD, Lin CY, Qi J, Zhang R, Artero PC, Alaiti MA, Bullard J, Alazem K, Margulies KB, Cappola TP, Lemieux M, Plutzky J, Bradner JE, Haldar SM. BET bromodomains mediate transcriptional pause release in heart failure Cell. 154: 569-582. PMID 23911322 DOI: 10.1016/J.Cell.2013.07.013  0.422
2013 Ahuja P, Wanagat J, Wang Z, Wang Y, Liem DA, Ping P, Antoshechkin IA, Margulies KB, Maclellan WR. Divergent mitochondrial biogenesis responses in human cardiomyopathy. Circulation. 127: 1957-67. PMID 23589024 DOI: 10.1161/Circulationaha.112.001219  0.414
2013 Pedrotty DM, Rame JE, Margulies KB. Management of ventricular arrhythmias in patients with ventricular assist devices. Current Opinion in Cardiology. 28: 360-8. PMID 23549232 DOI: 10.1097/Hco.0B013E32835Fb7Dc  0.332
2013 Fargnoli AS, Katz MG, Williams RD, Dvorak J, Walling T, Margulies KB, Bridges CR. A Novel Needleless Liquid Jet Injection System for Heart Failure Gene Therapy: Feasibility Study Demonstrates Enhanced Myocardial Distribution and Safety Profile in the Rodent Model Journal of Cardiac Failure. 19: S1-S2. DOI: 10.1016/J.Cardfail.2013.06.011  0.395
2012 Elser JA, Margulies KB. Hybrid Mathematical Model of Cardiomyocyte Turnover in the Adult Human Heart Plos One. 7. PMID 23284740 DOI: 10.1371/Journal.Pone.0051683  0.759
2012 Purcell BP, Elser JA, Mu A, Margulies KB, Burdick JA. Synergistic effects of SDF-1α chemokine and hyaluronic acid release from degradable hydrogels on directing bone marrow derived cell homing to the myocardium. Biomaterials. 33: 7849-57. PMID 22835643 DOI: 10.1016/J.Biomaterials.2012.07.005  0.754
2012 Houser SR, Margulies KB, Murphy AM, Spinale FG, Francis GS, Prabhu SD, Rockman HA, Kass DA, Molkentin JD, Sussman MA, Koch WJ, Koch W. Animal models of heart failure: a scientific statement from the American Heart Association. Circulation Research. 111: 131-50. PMID 22595296 DOI: 10.1161/Res.0B013E3182582523  0.405
2012 Despa S, Margulies KB, Chen L, Knowlton AA, Havel PJ, Taegtmeyer H, Bers DM, Despa F. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circulation Research. 110: 598-608. PMID 22275486 DOI: 10.1161/Circresaha.111.258285  0.416
2012 Shan X, Quaile MP, Monk JK, French B, Cappola TP, Margulies KB. Differential expression of PDE5 in failing and nonfailing human myocardium. Circulation. Heart Failure. 5: 79-86. PMID 22135403 DOI: 10.1161/Circheartfailure.111.961706  0.482
2012 Dickey DM, Dries DL, Margulies KB, Potter LR. Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human hearts: GC-A is inactive in the failed cardiomyocyte. Journal of Molecular and Cellular Cardiology. 52: 727-32. PMID 22133375 DOI: 10.1016/J.Yjmcc.2011.11.007  0.359
2012 Boudou T, Legant WR, Mu A, Borochin MA, Thavandiran N, Radisic M, Zandstra PW, Epstein JA, Margulies KB, Chen CS. A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. Tissue Engineering. Part A. 18: 910-9. PMID 22092279 DOI: 10.1089/Ten.Tea.2011.0341  0.38
2012 Elser JA, Purcell BP, Allana IA, Burdick JA, Margulies KB. Ischemia induces P-selectin-mediated selective progenitor cell engraftment in the isolated-perfused heart. Journal of Molecular and Cellular Cardiology. 52: 105-12. PMID 22047808 DOI: 10.1016/J.Yjmcc.2011.10.009  0.772
2012 Hellawell JL, Margulies KB. Myocardial reverse remodeling. Cardiovascular Therapeutics. 30: 172-81. PMID 21108773 DOI: 10.1111/J.1755-5922.2010.00247.X  0.41
2011 Margulies KB, Rame JE. Adaptations to pulsatile versus nonpulsatile ventricular assist device support. Circulation. Heart Failure. 4: 535-7. PMID 21934088 DOI: 10.1161/Circheartfailure.111.963777  0.496
2011 Belmonte SL, Margulies KB, Blaxall BC. S100A1: Another Step Toward Therapeutic Development for Heart Failure. Journal of the American College of Cardiology. 58: 974-6. PMID 21851888 DOI: 10.1016/J.Jacc.2011.04.032  0.445
2011 Barth AS, Kumordzie A, Frangakis C, Margulies KB, Cappola TP, Tomaselli GF. Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure. Circulation. Cardiovascular Genetics. 4: 475-83. PMID 21828333 DOI: 10.1161/Circgenetics.110.957571  0.427
2011 Shan X, Margulies KB. Differential regulation of PDE5 expression in left and right ventricles of feline hypertrophy models. Plos One. 6: e19922. PMID 21625548 DOI: 10.1371/Journal.Pone.0019922  0.303
2011 Walker JS, Walker LA, Margulies K, Buttrick P, de Tombe P. Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils. American Journal of Physiology. Heart and Circulatory Physiology. 301: H138-46. PMID 21498779 DOI: 10.1152/Ajpheart.00838.2010  0.309
2011 Norman HS, Oujiri J, Larue SJ, Chapman CB, Margulies KB, Sweitzer NK. Decreased cardiac functional reserve in heart failure with preserved systolic function. Journal of Cardiac Failure. 17: 301-8. PMID 21440868 DOI: 10.1016/J.Cardfail.2010.11.004  0.474
2011 Trivedi CM, Cappola TP, Margulies KB, Epstein JA. Homeodomain only protein x is down-regulated in human heart failure. Journal of Molecular and Cellular Cardiology. 50: 1056-8. PMID 21382376 DOI: 10.1016/J.Yjmcc.2011.02.015  0.485
2011 Dean AS, Libonati JR, Madonna D, Ratcliffe SJ, Margulies KB. Resistance training improves vasoreactivity in end-stage heart failure patients on inotropic support. The Journal of Cardiovascular Nursing. 26: 218-23. PMID 21263349 DOI: 10.1097/00005768-200405001-01154  0.39
2011 Lee CS, Moser DK, Lennie TA, Tkacs NC, Margulies KB, Riegel B. Biomarkers of myocardial stress and systemic inflammation in patients who engage in heart failure self-care management. The Journal of Cardiovascular Nursing. 26: 321-8. PMID 21263344 DOI: 10.1097/Jcn.0B013E31820344Be  0.357
2011 Guo D, Lian J, Liu T, Cox R, Margulies KB, Kowey PR, Yan GX. Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 8: 762-9. PMID 21184845 DOI: 10.1016/J.Hrthm.2010.12.026  0.304
2011 Methvin AB, Owens AT, Emmi AG, Allen M, Wiegers SE, Dries DL, Margulies KB, Forfia PR. Ventilatory inefficiency reflects right ventricular dysfunction in systolic heart failure. Chest. 139: 617-25. PMID 20688926 DOI: 10.1378/Chest.10-0318  0.44
2011 Margulies KB, Houser SR. Cellular Basis for Heart Failure Heart Failure. 32-47. DOI: 10.1016/B978-1-4160-5895-3.10003-8  0.352
2010 Codina M, Elser J, Margulies KB. Current status of stem cell therapy in heart failure Current Cardiology Reports. 12: 199-208. PMID 20424962 DOI: 10.1007/S11886-010-0098-5  0.799
2010 Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, Shimizu K, Kuivaniemi H, Sadoshima J, Margulies KB, Cappola TP, et al. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Science Translational Medicine. 2: 26ra26. PMID 20375365 DOI: 10.1126/Scitranslmed.3000502  0.41
2010 Despa S, Andronic F, Thai P, Walton JH, Margulies KB, Bers DM, Despa F. Iapp Preamyloid Oligomers Accumulate in the Heart and Contribute to Cardiac Dysfunction in Type-2 Diabetes Biophysical Journal. 98: 255a. DOI: 10.1016/J.Bpj.2009.12.1386  0.388
2009 Putt ME, Hannenhalli S, Lu Y, Haines P, Chandrupatla HR, Morrisey EE, Margulies KB, Cappola TP. Evidence for coregulation of myocardial gene expression by MEF2 and NFAT in human heart failure. Circulation. Cardiovascular Genetics. 2: 212-9. PMID 20031589 DOI: 10.1161/Circgenetics.108.816686  0.472
2009 Levin MD, Lu MM, Petrenko NB, Hawkins BJ, Gupta TH, Lang D, Buckley PT, Jochems J, Liu F, Spurney CF, Yuan LJ, Jacobson JT, Brown CB, Huang L, Beermann F, ... Margulies KB, et al. Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. The Journal of Clinical Investigation. 119: 3420-36. PMID 19855129 DOI: 10.1172/Jci39109  0.4
2009 Quaile MP, Kubo H, Kimbrough CL, Douglas SA, Margulies KB. Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium. Circulation. Heart Failure. 2: 39-46. PMID 19808314 DOI: 10.1161/Circheartfailure.107.748343  0.354
2009 Margulies KB. MicroRNAs as novel myocardial biomarkers. Clinical Chemistry. 55: 1897-9. PMID 19696114 DOI: 10.1373/Clinchem.2009.131649  0.388
2009 Margulies KB, Bednarik DP, Dries DL. Genomics, transcriptional profiling, and heart failure. Journal of the American College of Cardiology. 53: 1752-9. PMID 19422981 DOI: 10.1016/J.Jacc.2008.12.064  0.368
2009 Matkovich SJ, Van Booven DJ, Youker KA, Torre-Amione G, Diwan A, Eschenbacher WH, Dorn LE, Watson MA, Margulies KB, Dorn GW. Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Circulation. 119: 1263-71. PMID 19237659 DOI: 10.1161/Circulationaha.108.813576  0.386
2009 Elser JA, Bantly A, Margulies KB. Preferential Recruitment of Progenitors Following Myocardial Injury Journal of Cardiac Failure. 15: S20. DOI: 10.1016/J.Cardfail.2009.06.373  0.739
2009 Shan X, Haleem K, Margulies KB. Failing Human Hearts Display Elevated PDE5 Expression Levels in Right Ventricle Journal of Cardiac Failure. 15: S43. DOI: 10.1016/J.Cardfail.2009.06.307  0.408
2008 Fermin DR, Barac A, Lee S, Polster SP, Hannenhalli S, Bergemann TL, Grindle S, Dyke DB, Pagani F, Miller LW, Tan S, Dos Remedios C, Cappola TP, Margulies KB, Hall JL. Sex and age dimorphism of myocardial gene expression in nonischemic human heart failure. Circulation. Cardiovascular Genetics. 1: 117-25. PMID 20031553 DOI: 10.1161/Circgenetics.108.802652  0.398
2008 Shan X, Wang H, Margulies KB. Apoptosis signal-regulating kinase 1 attenuates atrial natriuretic peptide secretion. Biochemistry. 47: 10041-8. PMID 18759454 DOI: 10.1021/Bi800972Z  0.352
2008 Kubo H, Jaleel N, Kumarapeli A, Berretta RM, Bratinov G, Shan X, Wang H, Houser SR, Margulies KB. Increased cardiac myocyte progenitors in failing human hearts. Circulation. 118: 649-57. PMID 18645055 DOI: 10.1016/J.Cardfail.2008.06.102  0.483
2008 Mays TA, Binkley PF, Lesinski A, Doshi AA, Quaile MP, Margulies KB, Janssen PM, Rafael-Fortney JA. Claudin-5 levels are reduced in human end-stage cardiomyopathy. Journal of Molecular and Cellular Cardiology. 45: 81-7. PMID 18513742 DOI: 10.1016/J.Yjmcc.2008.04.005  0.349
2008 Chen X, Zhang X, Harris DM, Piacentino V, Berretta RM, Margulies KB, Houser SR. Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation. American Journal of Physiology. Heart and Circulatory Physiology. 294: H2257-67. PMID 18359894 DOI: 10.1152/Ajpheart.01335.2007  0.318
2008 Matkovich SJ, Margulies KB, Youker KA, Torre-Amione G, Van Booven DJ, Dorn GW. Reversibility of Signature miRNA Dysregulation in Failing Human Hearts by Mechanical Unloading Journal of Cardiac Failure. 14: S40. DOI: 10.1016/J.Cardfail.2008.06.286  0.33
2007 Quaile MP, Rossman EI, Berretta RM, Bratinov G, Kubo H, Houser SR, Margulies KB. Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload. Journal of Molecular and Cellular Cardiology. 43: 552-63. PMID 17931654 DOI: 10.1016/J.Yjmcc.2007.08.013  0.39
2007 Li J, Wei H, Chesley A, Moon C, Krawczyk M, Volkova M, Ziman B, Margulies KB, Talan M, Crow MT, Boheler KR. The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity. The Journal of Biological Chemistry. 282: 34984-93. PMID 17925408 DOI: 10.1074/Jbc.M703513200  0.409
2007 McGinley JC, Berretta RM, Chaudhary K, Rossman E, Bratinov GD, Gaughan JP, Houser S, Margulies KB. Impaired contractile reserve in severe mitral valve regurgitation with a preserved ejection fraction. European Journal of Heart Failure. 9: 857-64. PMID 17594913 DOI: 10.1016/J.Ejheart.2007.05.013  0.334
2007 Maybaum S, Mancini D, Xydas S, Starling RC, Aaronson K, Pagani FD, Miller LW, Margulies K, McRee S, Frazier OH, Torre-Amione G. Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group. Circulation. 115: 2497-505. PMID 17485581 DOI: 10.1161/Circulationaha.106.633180  0.401
2007 Pfister R, Acksteiner C, Baumgarth J, Burst V, Geissler HJ, Margulies KB, Houser S, Bloch W, Flesch M. Loss of beta1D-integrin function in human ischemic cardiomyopathy. Basic Research in Cardiology. 102: 257-64. PMID 17186162 DOI: 10.1007/S00395-006-0640-1  0.311
2007 Boateng SY, Belin RJ, Geenen DL, Margulies KB, Martin JL, Hoshijima M, de Tombe PP, Russell B. Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein. American Journal of Physiology. Heart and Circulatory Physiology. 292: H259-69. PMID 16963613 DOI: 10.1152/Ajpheart.00766.2006  0.461
2007 Kubo H, Juleel N, Chen X, Baretta R, Bratinov G, Shan X, Houser SR, Margulies KB. Endogenous Cardiac Repair in Human Hearts Journal of Cardiac Failure. 13: S81. DOI: 10.1016/J.Cardfail.2007.06.328  0.464
2006 Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstein JA, Morrisey EE, Margulies KB, Cappola TP. Transcriptional genomics associates FOX transcription factors with human heart failure. Circulation. 114: 1269-76. PMID 16952980 DOI: 10.1161/Circulationaha.106.632430  0.445
2006 Margulies KB, Burnett JC. Visualizing the basis for paracrine natriuretic peptide signaling in human heart. Circulation Research. 99: 113-5. PMID 16857970 DOI: 10.1161/01.Res.0000234911.22854.D9  0.331
2006 Grzywacz FW, Piacentino V, Marble J, Bozorgnia B, Gaughan JP, Rothman SA, Margulies KB. Effect of acute unloading via head-up tilt on QTc prolongation in patients with ischemic or non-ischemic cardiomyopathy. The American Journal of Cardiology. 97: 412-5. PMID 16442407 DOI: 10.1016/J.Amjcard.2005.08.064  0.424
2006 Litvin J, Blagg A, Mu A, Matiwala S, Montgomery M, Berretta R, Houser S, Margulies K. Periostin and periostin-like factor in the human heart: possible therapeutic targets. Cardiovascular Pathology : the Official Journal of the Society For Cardiovascular Pathology. 15: 24-32. PMID 16414453 DOI: 10.1016/J.Carpath.2005.09.001  0.425
2006 Jung AS, Kubo H, Wilson R, Houser SR, Margulies KB. Modulation of contractility by myocyte-derived arginase in normal and hypertrophied feline myocardium. American Journal of Physiology. Heart and Circulatory Physiology. 290: H1756-62. PMID 16327014 DOI: 10.1152/Ajpheart.01104.2005  0.448
2006 Boateng S, Belin R, Geenen D, Margulies K, deTombe P, Russell B. A47. Decreased levels of non-nuclear muscle LIM protein are associated with cardiac dysfunction and heart failure Journal of Molecular and Cellular Cardiology. 40: 864. DOI: 10.1016/J.Yjmcc.2006.03.285  0.411
2006 Quaile MP, Margulies KB. Urotensin-II Upregulation in Human Heart Failure: Direct Effects on Contractility and Sarcoplasmic Reticulum Calcium Load Journal of Cardiac Failure. 12: S12. DOI: 10.1016/J.Cardfail.2006.06.047  0.351
2005 Petre RE, Quaile MP, Wendt K, Houser SR, Wald J, Goldman BI, Margulies KB. Regionally heterogeneous tissue mechanics in cardiac amyloidosis. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 12: 246-50. PMID 16399650 DOI: 10.1080/13506120500386824  0.432
2005 Iaccarino G, Barbato E, Cipolletta E, De Amicis V, Margulies KB, Leosco D, Trimarco B, Koch WJ. Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. European Heart Journal. 26: 1752-8. PMID 16055494 DOI: 10.1093/Eurheartj/Ehi429  0.405
2005 Dean AS, Margulies KB, Nicholas JJ, Rubin S, Gaughan JP, Libonati JR. Impaired vasoreactivity in end-stage heart failure patients on intravenous inotropic support. Journal of Cardiac Failure. 11: 351-7. PMID 15948085 DOI: 10.1016/J.Cardfail.2004.12.002  0.461
2005 McGinley JC, Berretta RM, Bratinov GD, Dhar S, Gaughan JP, Margulies KB. Subvalvular alterations promote increased mitral valve regurgitation in progressive dilated cardiomyopathy. Journal of Cardiac Failure. 11: 343-50. PMID 15948084 DOI: 10.1016/J.Cardfail.2004.12.003  0.366
2005 Harding JD, Piacentino V, Rothman S, Chambers S, Jessup M, Margulies KB. Prolonged repolarization after ventricular assist device support is associated with arrhythmias in humans with congestive heart failure. Journal of Cardiac Failure. 11: 227-32. PMID 15812752 DOI: 10.1016/J.Cardfail.2004.08.158  0.45
2005 Margulies KB, Matiwala S, Cornejo C, Olsen H, Craven WA, Bednarik D. Mixed messages: transcription patterns in failing and recovering human myocardium. Circulation Research. 96: 592-9. PMID 15718504 DOI: 10.1161/01.Res.0000159390.03503.C3  0.476
2004 Matiwala S, Margulies KB. Mechanical approaches to alter remodeling. Current Heart Failure Reports. 1: 14-8. PMID 16036020 DOI: 10.1007/S11897-004-0012-9  0.452
2004 Chaudhary KW, Rossman EI, Piacentino V, Kenessey A, Weber C, Gaughan JP, Ojamaa K, Klein I, Bers DM, Houser SR, Margulies KB. Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart. Journal of the American College of Cardiology. 44: 837-45. PMID 15312868 DOI: 10.1016/J.Jacc.2004.05.049  0.447
2004 Rossman EI, Petre RE, Chaudhary KW, Piacentino V, Janssen PM, Gaughan JP, Houser SR, Margulies KB. Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium. Journal of Molecular and Cellular Cardiology. 36: 33-42. PMID 14734045 DOI: 10.1016/J.Yjmcc.2003.09.001  0.397
2004 McGinley JC, Berretta RM, Margulies KB. A CANINE MODEL OF CHRONIC MITRAL VALVE REGURGITATION WITH PRESERVATION OF RESTING CARDIAC FUNCTION Asaio Journal. 50: 112. DOI: 10.1097/00002480-200403000-00005  0.358
2004 Cappola TP, Matiwala S, Cornejo C, Epstein JA, Margulies K. Downregulation of homeodomain only protein (Hop) in human heart failure Journal of Cardiac Failure. 10: S55. DOI: 10.1016/J.Cardfail.2004.06.132  0.434
2004 Matiwala SN, Margulies KB. Identification of Beta-Blocker Responsive Genes in Human Heart Failure with a Multi-Comparison Pharmacogenomic Analysis Journal of Cardiac Failure. 10: S26. DOI: 10.1016/J.Cardfail.2004.06.030  0.409
2004 Margulies KB, Fiss DM, Jung AS, Bratinov G, Marble J. Abnormal rate-dependent contractile reserve in heart failure-with normal ejection fraction Journal of Cardiac Failure. 10: S25. DOI: 10.1016/J.Cardfail.2004.06.025  0.443
2003 Margulies KB. Blocking stretch-induced myocardial remodeling. Circulation Research. 93: 1020-2. PMID 14645132 DOI: 10.1161/01.Res.0000105922.61310.D4  0.495
2003 Fedalen PA, Piacentino V, Jeevanandam V, Fisher C, Greene J, Margulies KB, Houser SR, Furukawa S, Singhal AK, Goldman BI. Pharmacologic pre-conditioning and controlled reperfusion prevent ischemia-reperfusion injury after 30 minutes of hypoxia/ischemia in porcine hearts. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 22: 1234-44. PMID 14585385 DOI: 10.1016/S1053-2498(02)01237-8  0.442
2003 Kashem A, Kashem S, Santamore WP, Crabbe DL, Margulies KB, Melvin DB, Goldman BI. Early and late results of left ventricular reshaping by passive cardiac-support device in canine heart failure. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 22: 1046-53. PMID 12957615 DOI: 10.1016/S1053-2498(02)01162-2  0.408
2003 Houser SR, Margulies KB. Is depressed myocyte contractility centrally involved in heart failure? Circulation Research. 92: 350-8. PMID 12623873 DOI: 10.1161/01.Res.0000060027.40275.A6  0.469
2003 Boheler KR, Volkova M, Morrell C, Garg R, Zhu Y, Margulies K, Seymour AM, Lakatta EG. Sex- and age-dependent human transcriptome variability: implications for chronic heart failure. Proceedings of the National Academy of Sciences of the United States of America. 100: 2754-9. PMID 12601168 DOI: 10.1073/Pnas.0436564100  0.398
2003 Crabbe DL, Dipla K, Ambati S, Zafeiridis A, Gaughan JP, Houser SR, Margulies KB. Gender differences in post-infarction hypertrophy in end-stage failing hearts. Journal of the American College of Cardiology. 41: 300-6. PMID 12535826 DOI: 10.1016/S0735-1097(02)02710-9  0.481
2003 Rossman EI, Berretta RM, Petre RE, Chaudhary KW, Gaughan JP, Houser SR, Margulies KB. Sarcomere length-tension relationship in failing human myocardium Journal of Cardiac Failure. 9: S15. DOI: 10.1016/S1071-9164(03)00283-5  0.427
2003 Maybaum S, Frazier O, Starling RC, Miller L, Aaronson K, Murali S, Margulies K, McRee SC, Torre G. Cardiac recovery during support with a left ventricular assist device. Results from the LVAD working group Journal of Cardiac Failure. 9: S9. DOI: 10.1016/S1071-9164(03)00210-0  0.364
2003 Maybaum S, Frazier O, Starling RC, Miller L, Murali S, Aaronson KD, Margulies K, McRee S, Torre G. Cardiac recovery during 30 days of support with a left ventricular assist device. Preliminary results from the LVAD working group Journal of the American College of Cardiology. 41: 165-166. DOI: 10.1016/S0735-1097(03)81813-2  0.358
2002 Margulies KB. Reversal mechanisms of left ventricular remodeling: lessons from left ventricular assist device experiments. Journal of Cardiac Failure. 8: S500-5. PMID 12555165 DOI: 10.1054/Jcaf.2002.129264  0.5
2002 Weber CR, Piacentino V, Margulies KB, Bers DM, Houser SR. Calcium influx via I(NCX) is favored in failing human ventricular myocytes. Annals of the New York Academy of Sciences. 976: 478-9. PMID 12502599 DOI: 10.1111/J.1749-6632.2002.Tb04779.X  0.304
2002 Piacentino V, Weber CR, Gaughan JP, Margulies KB, Bers DM, Houser SR. Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange. Annals of the New York Academy of Sciences. 976: 466-71. PMID 12502596 DOI: 10.1111/J.1749-6632.2002.Tb04776.X  0.304
2002 Margulies KB. Contractile protein abnormalities in failing hearts. Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology. 9: 413-8. PMID 12161718 DOI: 10.1067/Mnc.2002.125812  0.425
2002 Kashem A, Santamore WP, Hassan S, Crabbe DL, Margulies KB, Melvin DB. CardioClasp: A new passive device to reshape cardiac enlargement Asaio Journal. 48: 253-259. PMID 12058999 DOI: 10.1097/00002480-200205000-00010  0.459
2002 Hassan S, Kashem A, Santamore WP, Crabee DL, Daley AM, Margulies KB, Melvin DB. CONTRACTILE RECOVERY BY CARDIOCLASP DEVICE IN HEART FAILURE Asaio Journal. 48: 167. DOI: 10.1097/00002480-200203000-00171  0.423
2002 Kashem A, Hassan S, Santamore WP, Crabbe DL, Margulies KB, Coldman B, Melvin DB. CHRONIC IMPLANT CARDIOCLASP CAN MAINTAIN IMPROVED MYOCARDIAL FUNCTION IN EXPERIMENTAL HEART FAILURE Asaio Journal. 48: 161. DOI: 10.1097/00002480-200203000-00145  0.421
2002 Kashem A, Hassan S, Santamore W, Crabbe D, Margulies K, Melvin D, Goldman B. Left ventricular reshaping by cardioclasp device enhances contractility and improves systolic function in dilated cardiomyopathy The Journal of Heart and Lung Transplantation. 21: 126. DOI: 10.1016/S1053-2498(01)00631-3  0.339
2001 Flesch M, Margulies KB, Mochmann HC, Engel D, Sivasubramanian N, Mann DL. Differential regulation of mitogen-activated protein kinases in the failing human heart in response to mechanical unloading. Circulation. 104: 2273-6. PMID 11696464 DOI: 10.1161/Hc4401.099449  0.415
2001 Harding JD, Piacentino V, Gaughan JP, Houser SR, Margulies KB. Electrophysiological alterations after mechanical circulatory support in patients with advanced cardiac failure. Circulation. 104: 1241-7. PMID 11551874 DOI: 10.1161/Hc3601.095718  0.473
2001 Kubo H, Margulies KB, Piacentino V, Gaughan JP, Houser SR. Patients with end-stage congestive heart failure treated with beta-adrenergic receptor antagonists have improved ventricular myocyte calcium regulatory protein abundance. Circulation. 104: 1012-8. PMID 11524394 DOI: 10.1161/Hc3401.095073  0.356
2001 Welsh DC, Dipla K, McNulty PH, Mu A, Ojamaa KM, Klein I, Houser SR, Margulies KB. Preserved contractile function despite atrophic remodeling in unloaded rat hearts American Journal of Physiology - Heart and Circulatory Physiology. 281. PMID 11514279 DOI: 10.1152/Ajpheart.2001.281.3.H1131  0.403
2000 Margulies KB. Ventricular unloading and myocyte recovery: Insight gained into the pathophysiology of congestive heart failure Current Cardiology Reports. 2: 181-188. PMID 10980891 DOI: 10.1007/S11886-000-0067-5  0.503
2000 Yang Y, Chen X, Margulies K, Jeevanandam V, Pollack P, Bailey BA, Houser SR. L-type Ca2+ channel α(1c) subunit isoform switching in failing human ventricular myocardium Journal of Molecular and Cellular Cardiology. 32: 973-984. PMID 10888251 DOI: 10.1006/Jmcc.2000.1138  0.419
1999 Gaughan JP, Furukawa S, Jeevanandam V, Hefner CA, Kubo H, Margulies KB, McGowan BS, Mattiello JA, Dipla K, Piacentino V, Li S, Houser SR. Sodium/calcium exchange contributes to contraction and relaxation in failed human ventricular myocytes. The American Journal of Physiology. 277: H714-24. PMID 10444498 DOI: 10.1152/Ajpheart.1999.277.2.H714  0.337
1999 Margulies KB, Jaffer S, Pollack PS, Ennis KJ. Physiological significance of early deceleration time prolongation in asymptomatic elderly subjects. Journal of Cardiac Failure. 5: 92-9. PMID 10404348 DOI: 10.1016/S1071-9164(99)90031-3  0.306
1998 Zafeiridis A, Jeevanandam V, Houser SR, Margulies KB. Regression of cellular hypertrophy after left ventricular assist device support Circulation. 98: 656-662. PMID 9715858 DOI: 10.1161/01.Cir.98.7.656  0.484
1998 Dipla K, Mattiello JA, Jeevanandam V, Houser SR, Margulies KB. Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure. Circulation. 97: 2316-22. PMID 9639375 DOI: 10.1161/01.Cir.97.23.2316  0.468
1998 Goldman BI, Fisher CA, Johnston E, Margulies KB, Wurzel J, Martin JL. Caspase-3 expression in failing human hearts Journal of Cardiac Failure. 4: 22. DOI: 10.1016/S1071-9164(98)90081-1  0.398
1998 Zafeiridis A, Dipla K, Filate W, Houser S, Margulies K. Cellular hypertrophy in pacing-induced cardiomyopathy Journal of the American College of Cardiology. 31: 243-244. DOI: 10.1016/S0735-1097(98)81698-7  0.34
1997 Altemose GT, Gritsus V, Jeevanandam V, Goldman B, Margulies KB. Altered myocardial phenotype after mechanical support in human beings with advanced cardiomyopathy Journal of Heart and Lung Transplantation. 16: 765-773. PMID 9257259  0.314
1996 Mather PJ, Jeevanandam V, Piña IL, Margulies KB, Eisen HJ, Bove AA. Two year follow-up of the functional and morphologic adaptation of undersized donor hearts following cardiac transplantation Journal of the American College of Cardiology. 27: 145. DOI: 10.1016/S0735-1097(96)80801-1  0.393
1996 Altemose G, Gritsus V, Goldman B, Jeevanandam V, Margulies K. Altered myocardial phenotype following mechanical support in humans with advanced cardiomyopathy Journal of the American College of Cardiology. 27: 88. DOI: 10.1016/S0735-1097(96)80555-9  0.368
1995 Margulies KB, Barclay PL, Burnett JC. The role of neutral endopeptidase in dogs with evolving congestive heart failure. Circulation. 91: 2036-42. PMID 7895362 DOI: 10.1161/01.Cir.91.7.2036  0.442
1995 Mather PJ, Jeevanandam V, Eisen HJ, Piña IL, Margulies KB, McClurken J, Furakawa S, Bove AA. Functional and morphologic adaptation of undersized donor hearts after heart transplantation. Journal of the American College of Cardiology. 26: 737-42. PMID 7642868 DOI: 10.1016/0735-1097(95)00216-Q  0.366
1994 Margulies KB, Burnett JC. Inhibition of cyclic GMP phosphodiesterases augments renal responses to atrial natriuretic factor in congestive heart failure Journal of Cardiac Failure. 1: 71-80. PMID 9420635 DOI: 10.1016/1071-9164(94)90010-8  0.35
1991 Perrella MA, Margulies KB, Wei CM, Aarhus LL, Heublein DM, Burnett JC. Pulmonary and urinary clearance of atrial natriuretic factor in acute congestive heart failure in dogs Journal of Clinical Investigation. 87: 1649-1655. PMID 1850758 DOI: 10.1172/Jci115180  0.334
1991 Perrella MA, Margulies KB, Burnett JC. Pathophysiology of congestive heart failure: Role of atrial natriuretic factor and therapeutic implications Canadian Journal of Physiology and Pharmacology. 69: 1576-1581. PMID 1838025 DOI: 10.1139/Y91-234  0.436
1991 Margulies KB, Perrella MA, McKinley LJ, Burnett JC. Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure Journal of Clinical Investigation. 88: 1636-1642. PMID 1658047 DOI: 10.1172/Jci115477  0.308
1991 Margulies KB, McKinley LJ, Schirger JA, Burnett JC. Attenuated ANF-mediated nephrogenous cyclic GMP gensation in advanced congestive heart failure Journal of the American College of Cardiology. 17: A22. DOI: 10.1016/0735-1097(91)91053-H  0.454
1990 Margulies KB, Hildebrand FL, Lerman A, Perrella MA, Burnett JC. Increased endothelin in experimental heart failure Circulation. 82: 2226-2230. PMID 2242543 DOI: 10.1161/01.Cir.82.6.2226  0.387
1990 Cavero PG, Miller WL, Heublein DM, Margulies KB, Burnett JC. Endothelin in experimental congestive heart failure in the anesthetized dog American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 259. PMID 2201206 DOI: 10.1152/Ajprenal.1990.259.2.F312  0.313
1990 Margulies KB, McKinley LJ, Cavero PG, Burnett JC. Induction and prevention of radiocontrast-induced nephropathy in dogs with heart failure Kidney International. 38: 1101-1108. PMID 2150085 DOI: 10.1038/Ki.1990.319  0.359
1990 Margulies KB, Burnett JC. Atrial natriuretic factor modulates whole kidney tubuloglomerular feedback American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 259. PMID 2142863 DOI: 10.1152/Ajpregu.1990.259.1.R97  0.435
1990 Cavero PG, Margulies KB, Winaver J, Seymour AA, Delaney NG, Burnett JC. Cardiorenal actions of neutral endopeptidase inhibition in experimental congestive heart failure. Circulation. 82: 196-201. PMID 2142023 DOI: 10.1161/01.Cir.82.1.196  0.356
1990 Margulies KB, Burnett JC. Inappropriate renal hemodynamic response to hypertonic saline in dogs with experimental acute congestive heart failure Journal of the American College of Cardiology. 15: A150. DOI: 10.1016/0735-1097(90)92316-T  0.404
1990 Margulies KB, Schirger JA, Burnett JC. Atrial natriuretic factor prevents radiocontrast-induced nephropathy in dogs with experimental heart failure Journal of the American College of Cardiology. 15: A77. DOI: 10.1016/0735-1097(90)92025-W  0.438
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