| Year |
Citation |
Score |
| 2020 |
Valderrama-Gómez MÁ, Lomnitz JG, Fasani RA, Savageau MA. Mechanistic Modeling of Biochemical Systems without A Priori Parameter Values Using the Design Space Toolbox v.3.0. Iscience. 23: 101200. PMID 32531747 DOI: 10.1016/J.Isci.2020.101200 |
0.787 |
|
| 2016 |
Lomnitz JG, Savageau MA. Rapid Discrimination Among Putative Mechanistic Models of Biochemical Systems. Scientific Reports. 6: 32375. PMID 27578053 DOI: 10.1038/Srep32375 |
0.408 |
|
| 2016 |
Lomnitz JG, Savageau MA. Design Space Toolbox V2: Automated Software Enabling a Novel Phenotype-Centric Modeling Strategy for Natural and Synthetic Biological Systems. Frontiers in Genetics. 7: 118. PMID 27462346 DOI: 10.3389/Fgene.2016.00118 |
0.429 |
|
| 2015 |
Fasani RA, Savageau MA. Unrelated toxin-antitoxin systems cooperate to induce persistence. Journal of the Royal Society, Interface / the Royal Society. 12: 20150130. PMID 26063817 DOI: 10.1098/Rsif.2015.0130 |
0.782 |
|
| 2015 |
Tolla DA, Kiley PJ, Lomnitz JG, Savageau MA. Design principles of a conditional futile cycle exploited for regulation. Molecular Biosystems. 11: 1841-9. PMID 25851148 DOI: 10.1039/C5Mb00055F |
0.763 |
|
| 2014 |
Fasani RA, Savageau MA. Evolution of a genome-encoded bias in amino acid biosynthetic pathways is a potential indicator of amino acid dynamics in the environment. Molecular Biology and Evolution. 31: 2865-78. PMID 25118252 DOI: 10.1093/Molbev/Msu225 |
0.769 |
|
| 2014 |
Lomnitz JG, Savageau MA. Strategy revealing phenotypic differences among synthetic oscillator designs. Acs Synthetic Biology. 3: 686-701. PMID 25019938 DOI: 10.1021/Sb500236E |
0.42 |
|
| 2013 |
Lomnitz JG, Savageau MA. Phenotypic deconstruction of gene circuitry. Chaos (Woodbury, N.Y.). 23: 025108. PMID 23822506 DOI: 10.1063/1.4809776 |
0.418 |
|
| 2013 |
Fasani RA, Savageau MA. Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype. Proceedings of the National Academy of Sciences of the United States of America. 110: E2528-37. PMID 23781105 DOI: 10.1073/Pnas.1301023110 |
0.784 |
|
| 2013 |
Williams K, Savageau MA, Blumenthal RM. A bistable hysteretic switch in an activator-repressor regulated restriction-modification system. Nucleic Acids Research. 41: 6045-57. PMID 23630319 DOI: 10.1093/Nar/Gkt324 |
0.376 |
|
| 2012 |
Martínez-Antonio A, Lomnitz JG, Sandoval S, Aldana M, Savageau MA. Regulatory design governing progression of population growth phases in bacteria. Plos One. 7: e30654. PMID 22363461 DOI: 10.1371/Journal.Pone.0030654 |
0.327 |
|
| 2011 |
Savageau MA. Design of the lac gene circuit revisited. Mathematical Biosciences. 231: 19-38. PMID 21414326 DOI: 10.1016/J.Mbs.2011.03.008 |
0.453 |
|
| 2011 |
Savageau MA. Biomedical engineering strategies in system design space. Annals of Biomedical Engineering. 39: 1278-95. PMID 21203848 DOI: 10.1007/S10439-010-0220-2 |
0.43 |
|
| 2011 |
Tolla DA, Savageau MA. Phenotypic repertoire of the FNR regulatory network in Escherichia coli. Molecular Microbiology. 79: 149-65. PMID 21166900 DOI: 10.1111/J.1365-2958.2010.07437.X |
0.77 |
|
| 2010 |
Coelho PM, Salvador A, Savageau MA. Relating mutant genotype to phenotype via quantitative behavior of the NADPH redox cycle in human erythrocytes. Plos One. 5. PMID 20927393 DOI: 10.1371/Journal.Pone.0013031 |
0.383 |
|
| 2010 |
Fasani RA, Savageau MA. Automated construction and analysis of the design space for biochemical systems. Bioinformatics (Oxford, England). 26: 2601-9. PMID 20823298 DOI: 10.1093/Bioinformatics/Btq479 |
0.781 |
|
| 2010 |
Tolla DA, Savageau MA. Regulation of aerobic-to-anaerobic transitions by the FNR cycle in Escherichia coli. Journal of Molecular Biology. 397: 893-905. PMID 20156450 DOI: 10.1016/J.Jmb.2010.02.015 |
0.757 |
|
| 2010 |
Reams AB, Kofoid E, Savageau M, Roth JR. Duplication frequency in a population of Salmonella enterica rapidly approaches steady state with or without recombination. Genetics. 184: 1077-94. PMID 20083614 DOI: 10.1534/Genetics.109.111963 |
0.321 |
|
| 2009 |
Savageau MA, Fasani RA. Qualitatively distinct phenotypes in the design space of biochemical systems. Febs Letters. 583: 3914-22. PMID 19879266 DOI: 10.1016/J.Febslet.2009.10.073 |
0.784 |
|
| 2009 |
Coelho PM, Salvador A, Savageau MA. Quantifying global tolerance of biochemical systems: design implications for moiety-transfer cycles. Plos Computational Biology. 5: e1000319. PMID 19300483 DOI: 10.1371/Journal.Pcbi.1000319 |
0.375 |
|
| 2009 |
Savageau MA, Coelho PM, Fasani RA, Tolla DA, Salvador A. Phenotypes and tolerances in the design space of biochemical systems. Proceedings of the National Academy of Sciences of the United States of America. 106: 6435-40. PMID 19279208 DOI: 10.1073/Pnas.0809869106 |
0.739 |
|
| 2008 |
Igoshin OA, Alves R, Savageau MA. Hysteretic and graded responses in bacterial two-component signal transduction. Molecular Microbiology. 68: 1196-215. PMID 18363790 DOI: 10.1111/J.1365-2958.2008.06221.X |
0.349 |
|
| 2007 |
Igoshin OA, Brody MS, Price CW, Savageau MA. Distinctive topologies of partner-switching signaling networks correlate with their physiological roles. Journal of Molecular Biology. 369: 1333-52. PMID 17498739 DOI: 10.1016/J.Jmb.2007.04.021 |
0.32 |
|
| 2006 |
Igoshin OA, Price CW, Savageau MA. Signalling network with a bistable hysteretic switch controls developmental activation of the sigma transcription factor in Bacillus subtilis. Molecular Microbiology. 61: 165-84. PMID 16824103 DOI: 10.1111/J.1365-2958.2006.05212.X |
0.327 |
|
| 2006 |
Salvador A, Savageau MA. Evolution of enzymes in a series is driven by dissimilar functional demands. Proceedings of the National Academy of Sciences of the United States of America. 103: 2226-31. PMID 16461898 DOI: 10.1073/Pnas.0510776103 |
0.351 |
|
| 2004 |
Wall ME, Hlavacek WS, Savageau MA. Design of gene circuits: lessons from bacteria. Nature Reviews. Genetics. 5: 34-42. PMID 14708014 DOI: 10.1038/Nrg1244 |
0.59 |
|
| 2003 |
Salvador A, Savageau MA. Quantitative evolutionary design of glucose 6-phosphate dehydrogenase expression in human erythrocytes. Proceedings of the National Academy of Sciences of the United States of America. 100: 14463-8. PMID 14614139 DOI: 10.1073/Pnas.2335687100 |
0.403 |
|
| 2003 |
Wall ME, Hlavacek WS, Savageau MA. Design principles for regulator gene expression in a repressible gene circuit. Journal of Molecular Biology. 332: 861-76. PMID 12972257 DOI: 10.1016/S0022-2836(03)00948-3 |
0.599 |
|
| 2003 |
Atkinson MR, Savageau MA, Myers JT, Ninfa AJ. Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli. Cell. 113: 597-607. PMID 12787501 DOI: 10.1016/S0092-8674(03)00346-5 |
0.362 |
|
| 2003 |
Alves R, Savageau MA. Comparative analysis of prototype two-component systems with either bifunctional or monofunctional sensors: differences in molecular structure and physiological function. Molecular Microbiology. 48: 25-51. PMID 12657043 DOI: 10.1046/J.1365-2958.2003.03344.X |
0.309 |
|
| 2002 |
Savageau MA. Alternative designs for a genetic switch: analysis of switching times using the piecewise power-law representation. Mathematical Biosciences. 180: 237-53. PMID 12387925 DOI: 10.1016/S0025-5564(02)00113-X |
0.357 |
|
| 2002 |
Oosawa C, Savageau MA. Statistical Properties of Randomly Constructed Boolean Networks that Resemble the Transcription Factor Network of Escherichia coli Genome Informatics. 13: 375-376. DOI: 10.11234/Gi1990.13.375 |
0.332 |
|
| 2001 |
Savageau MA. Design principles for elementary gene circuits: Elements, methods, and examples. Chaos (Woodbury, N.Y.). 11: 142-159. PMID 12779449 DOI: 10.1063/1.1349892 |
0.374 |
|
| 2000 |
Alves R, Savageau MA. Effect of overall feedback inhibition in unbranched biosynthetic pathways Biophysical Journal. 79: 2290-2304. PMID 11053109 DOI: 10.1016/S0006-3495(00)76475-7 |
0.346 |
|
| 2000 |
Alves R, Savageau MA. Systemic properties of ensembles of metabolic networks: Application of graphical and statistical methods to simple unbranched pathways Bioinformatics. 16: 534-547. PMID 10980151 DOI: 10.1093/Bioinformatics/16.6.534 |
0.366 |
|
| 2000 |
Alves R, Savageau MA. Comparing systemic properties of ensembles of biological networks by graphical and statistical methods Bioinformatics. 16: 527-533. PMID 10980150 DOI: 10.1093/Bioinformatics/16.6.527 |
0.346 |
|
| 1998 |
Savageau MA. Development of fractal kinetic theory for enzyme-catalysed reactions and implications for the design of biochemical pathways Biosystems. 47: 9-36. PMID 9715749 DOI: 10.1016/S0303-2647(98)00020-3 |
0.326 |
|
| 1997 |
Hlavacek WS, Savageau MA. Completely uncoupled and perfectly coupled gene expression in repressible systems. Journal of Molecular Biology. 266: 538-58. PMID 9067609 DOI: 10.1006/Jmbi.1996.0811 |
0.635 |
|
| 1996 |
Ni TC, Savageau MA. Model assessment and refinement using strategies from biochemical systems theory: application to metabolism in human red blood cells. Journal of Theoretical Biology. 179: 329-68. PMID 8763353 DOI: 10.1006/Jtbi.1996.0072 |
0.373 |
|
| 1996 |
Ni TC, Savageau MA. Application of biochemical systems theory to metabolism in human red blood cells: Signal propagation and accuracy of representation Journal of Biological Chemistry. 271: 7927-7941. PMID 8626472 DOI: 10.1074/Jbc.271.14.7927 |
0.376 |
|
| 1996 |
Hlavacek WS, Savageau MA. Rules for coupled expression of regulator and effector genes in inducible circuits. Journal of Molecular Biology. 255: 121-39. PMID 8568860 DOI: 10.1006/Jmbi.1996.0011 |
0.614 |
|
| 1995 |
Hlavacek WS, Savageau MA. Subunit structure of regulator proteins influences the design of gene circuitry: analysis of perfectly coupled and completely uncoupled circuits. Journal of Molecular Biology. 248: 739-55. PMID 7752237 DOI: 10.1006/Jmbi.1995.0257 |
0.622 |
|
| 1994 |
Reilly SL, Sing CF, Savageau MA, Turner ST. Analysis of systems influencing renal hemodynamics and sodium excretion. I. Biochemical systems theory Integrative Physiological and Behavioral Science. 29: 55-73. PMID 8018552 DOI: 10.1007/Bf02691281 |
0.318 |
|
| 1993 |
Savageau MA. Influence of fractal kinetics on molecular recognition Journal of Molecular Recognition : Jmr. 6: 149-157. PMID 7917410 DOI: 10.1002/Jmr.300060403 |
0.308 |
|
| 1991 |
Savageau MA. Biochemical systems theory: Operational differences among variant representations and their significance Journal of Theoretical Biology. 151: 509-530. PMID 1943154 DOI: 10.1016/S0022-5193(05)80367-4 |
0.37 |
|
| 1989 |
Savageau MA, Sorribas A. Constraints among molecular and systemic properties: Implications for physiological genetics Journal of Theoretical Biology. 141: 93-115. PMID 2634164 DOI: 10.1016/S0022-5193(89)80011-6 |
0.381 |
|
| 1989 |
Sorribas A, Savageau MA. Strategies for representing metabolic pathways within biochemical systems theory: Reversible pathways Mathematical Biosciences. 94: 239-269. PMID 2520170 DOI: 10.1016/0025-5564(89)90066-7 |
0.399 |
|
| 1989 |
Sorribas A, Savageau MA. A comparison of variant theories of intact biochemical systems. II. flux-oriented and metabolic control theories Mathematical Biosciences. 94: 195-238. PMID 2520169 DOI: 10.1016/0025-5564(89)90065-5 |
0.311 |
|
| 1989 |
Sorribas A, Savageau MA. A comparison of variant theories of intact biochemical systems. I. enzyme-enzyme interactions and biochemical systems theory Mathematical Biosciences. 94: 161-193. PMID 2520168 DOI: 10.1016/0025-5564(89)90064-3 |
0.323 |
|
| 1988 |
Savageau MA. Introduction to S-systems and the underlying power-law formalism Mathematical and Computer Modelling. 11: 546-551. DOI: 10.1016/0895-7177(88)90553-5 |
0.33 |
|
| 1987 |
Voit EO, Savageau MA. Accuracy of alternative representations for integrated biochemical systems Biochemistry. 26: 6869-6880. PMID 3427048 DOI: 10.1021/Bi00395A042 |
0.547 |
|
| 1987 |
Savageau MA, Voit EO. Recasting nonlinear differential equations as S-systems: a canonical nonlinear form Mathematical Biosciences. 87: 83-115. DOI: 10.1016/0025-5564(87)90035-6 |
0.526 |
|
| 1987 |
Savageau MA, Voit EO, Irvine DH. Biochemical systems theory and metabolic control theory: 2. the role of summation and connectivity relationships Mathematical Biosciences. 86: 147-169. DOI: 10.1016/0025-5564(87)90008-3 |
0.579 |
|
| 1987 |
Savageau MA, Voit EO, Irvine DH. Biochemical systems theory and metabolic control theory: 1. fundamental similarities and differences Mathematical Biosciences. 86: 127-145. DOI: 10.1016/0025-5564(87)90007-1 |
0.591 |
|
| 1986 |
Savageau MA. Integrated function of a kinetic proofreading mechanism: Double-stage proofreading by isoleucyl-tRNA synthetase Biochemistry. 25: 1969-1975. PMID 3518797 DOI: 10.1021/Bi00356A020 |
0.302 |
|
| 1986 |
Voit EO, Savageau MA. Equivalence between S-systems and Volterra systems Mathematical Biosciences. 78: 47-55. DOI: 10.1016/0025-5564(86)90030-1 |
0.562 |
|
| 1984 |
Okamoto M, Savageau MA. Integrated function of a kinetic proofreading mechanism: Steady-state analysis testing internal consistency of data obtained in vivo and in vitro and predicting parameter values Biochemistry. 23: 1701-1709. PMID 6372860 DOI: 10.1021/Bi00303A019 |
0.332 |
|
| 1984 |
Voit EO, Savageau MA. Analytical solutions to a generalized growth equation Journal of Mathematical Analysis and Applications. 103: 380-386. DOI: 10.1016/0022-247X(84)90135-5 |
0.525 |
|
| 1983 |
Savageau MA. Regulation of differentiated cell-specific functions Proceedings of the National Academy of Sciences of the United States of America. 80: 1411-1415. PMID 6219393 DOI: 10.1073/Pnas.80.5.1411 |
0.321 |
|
| 1983 |
Savageau MA. Escherichia coli habitats, cell types, and molecular mechanisms of gene control American Naturalist. 122: 732-744. DOI: 10.1086/284168 |
0.31 |
|
| 1981 |
Savageau MA, Lapointe DS. Optimization of kinetic proofreading: a general method for derivation of the constraint relations and an exploration of a specific case. Journal of Theoretical Biology. 93: 157-77. PMID 7334818 DOI: 10.1016/0022-5193(81)90062-X |
0.32 |
|
| 1980 |
Freter RR, Savageau MA. Proofreading systems of multiple stages for improved accuracy of biological discrimination Journal of Theoretical Biology. 85: 99-123. PMID 7464165 DOI: 10.1016/0022-5193(80)90284-2 |
0.33 |
|
| 1980 |
Savageau MA. Growth equations: A general equation and a survey of special cases Mathematical Biosciences. 48: 267-278. DOI: 10.1016/0025-5564(80)90061-9 |
0.3 |
|
| 1979 |
Savageau MA. Feedforward inhibition in biosynthetic pathways: inhibition of the aminoacyl-tRNA synthetase by the penultimate product Journal of Theoretical Biology. 77: 385-404. PMID 491687 DOI: 10.1016/0022-5193(79)90016-X |
0.311 |
|
| 1979 |
Savageau MA. Allometric morphogenesis of complex systems: Derivation of the basic equations from first principles Proceedings of the National Academy of Sciences of the United States of America. 76: 6023-6025. DOI: 10.1073/Pnas.76.12.6023 |
0.336 |
|
| 1979 |
Savageau MA. Growth of complex systems can be related to the properties of their underlying determinants Proceedings of the National Academy of Sciences of the United States of America. 76: 5413-5417. DOI: 10.1073/Pnas.76.11.5413 |
0.324 |
|
| 1977 |
Bochner BR, Savageau MA. Generalized indicator plate for genetic, metabolic, and taxonomic studies with microorganisms Applied and Environmental Microbiology. 33: 434-444. PMID 322611 DOI: 10.1128/Aem.33.2.434-444.1977 |
0.308 |
|
| 1977 |
Savageau MA. Design of molecular control mechanisms and the demand for gene expression Proceedings of the National Academy of Sciences of the United States of America. 74: 5647-5651. PMID 271992 DOI: 10.1073/Pnas.74.12.5647 |
0.367 |
|
| 1975 |
Savageau MA. Optimal design of feedback control by inhibition - Dynamic Considerations Journal of Molecular Evolution. 5: 199-222. PMID 1159800 DOI: 10.1007/Bf01741242 |
0.358 |
|
| 1975 |
Savageau MA. Significance of autogenously regulated and constitutive synthesis of regulatory proteins in repressible biosynthetic systems Nature. 258: 208-214. PMID 1105191 DOI: 10.1038/258208A0 |
0.356 |
|
| 1974 |
Savageau MA. Genetic regulatory mechanisms and the ecological niche of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 71: 2453-2455. PMID 4601590 DOI: 10.1073/Pnas.71.6.2453 |
0.312 |
|
| 1974 |
Savageau MA. Optimal design of feedback control by inhibition - steady state considerations Journal of Molecular Evolution. 4: 139-156. PMID 4469274 DOI: 10.1007/Bf01732019 |
0.342 |
|
| 1974 |
Savageau MA. Comparison of classical and autogenous systems of regulation in inducible operons Nature. 252: 546-549. PMID 4431516 DOI: 10.1038/252546A0 |
0.356 |
|
| 1973 |
Kotre AM, Sullivan SJ, Savageau MA. Metabolic regulation by homoserine in Escherichia coli B/r Journal of Bacteriology. 116: 663-672. PMID 4147650 DOI: 10.1128/Jb.116.2.663-672.1973 |
0.311 |
|
| 1972 |
Savageau MA. The Behavior of Intact Biochemical Control Systems Current Topics in Cellular Regulation. 6: 63-130. DOI: 10.1016/B978-0-12-152806-5.50010-2 |
0.379 |
|
| 1971 |
Savageau MA. Parameter sensitivity as a criterion for evaluating and comparing the performance of biochemical systems Nature. 229: 542-544. PMID 4925348 DOI: 10.1038/229542A0 |
0.335 |
|
| 1971 |
Savageau MA. Concepts relating the behavior of biochemical systems to their underlying molecular properties Archives of Biochemistry and Biophysics. 145: 612-621. PMID 4332048 DOI: 10.1016/S0003-9861(71)80021-8 |
0.4 |
|
| 1971 |
Savageau MA. Erratum: "Parameter sensitivity as a criterion for evaluating and comparing the performance of biochemical systems" (Nature (1971) 229 (542)) Nature. 230: 264-265. DOI: 10.1038/230264E0 |
0.317 |
|
| 1970 |
Savageau MA. Biochemical systems analysis. III. Dynamic solutions using a power-law approximation Journal of Theoretical Biology. 26: 215-226. PMID 5434343 DOI: 10.1016/S0022-5193(70)80013-3 |
0.306 |
|
| 1970 |
Savageau MA, Steward JP. Repression of the threonine synthetase system in Escherichia coli. Archives of Biochemistry and Biophysics. 137: 181-4. PMID 4907804 DOI: 10.1016/0003-9861(70)90425-X |
0.639 |
|
| 1969 |
Seraydarian MW, Sato E, Savageau M, Harary I. In vitro studies of beating heart cells in culture. XII. The utilization of ATP and phosphocreatine in oligomycin and 2-deoxyglucose inhibited cells. Biochimica Et Biophysica Acta. 180: 264-70. PMID 5795469 DOI: 10.1016/0005-2728(69)90113-3 |
0.584 |
|
| 1969 |
Savageau MA. Biochemical systems analysis. I. Some mathematical properties of the rate law for the component enzymatic reactions Journal of Theoretical Biology. 25: 365-369. PMID 5387046 DOI: 10.1016/S0022-5193(69)80026-3 |
0.348 |
|
| 1968 |
Passeron S, Savageau MA, Harary I. Optimal conditions for palmitate oxidation by rat heart homogenates. UCLA-12-686 Ucla [Reports]. U. S. Atomic Energy Commission. 15. PMID 5732269 |
0.555 |
|
| 1968 |
Passeron S, Savageau MA, Harary I. Optimal conditions for palmitate oxidation by rat heart homogenates. Archives of Biochemistry and Biophysics. 128: 124-8. PMID 5677171 DOI: 10.1016/0003-9861(68)90014-3 |
0.577 |
|
| 1968 |
Savageau MA. A mathematical model of the contraction rate of myocardial cells Currents in Modern Biology. 2: 29-42. PMID 5656320 DOI: 10.1016/0303-2647(68)90030-0 |
0.346 |
|
| 1967 |
Savageau MA, Steward JP. Contraction rate of rat cardiac cells in culture: responses to prolonged perfusion Currents in Modern Biology. 1: 159-164. PMID 6060170 DOI: 10.1016/0303-2647(67)90047-0 |
0.599 |
|
| Show low-probability matches. |