| Year |
Citation |
Score |
| 2023 |
Spiller L, Manjula R, Leissing F, Basquin J, Bourilhon P, Sinitski D, Brandhofer M, Levecque S, Gerra S, Sabelleck B, Zhang L, Feederle R, Flatley A, Hoffmann A, Panstruga R, ... ... Lolis E, et al. Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells. Science Signaling. 16: eadg2621. PMID 37988455 DOI: 10.1126/scisignal.adg2621 |
0.309 |
|
| 2023 |
Chen E, Widjaja V, Kyro G, Allen B, Das P, Prahaladan VM, Bhandari V, Lolis EJ, Batista VS, Lisi GP. Mapping N- to C-terminal Allosteric Coupling through Disruption of a Putative CD74 Activation Site in D-dopachrome Tautomerase. The Journal of Biological Chemistry. 104729. PMID 37080391 DOI: 10.1016/j.jbc.2023.104729 |
0.311 |
|
| 2022 |
Shillingford S, Zhang L, Surovtseva Y, Dorry S, Lolis E, Bennett AM. A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding. The Journal of Biological Chemistry. 102617. PMID 36272649 DOI: 10.1016/j.jbc.2022.102617 |
0.315 |
|
| 2022 |
Skeens E, Pantouris G, Shah D, Manjula R, Ombrello MJ, Maluf NK, Bhandari V, Lisi GP, Lolis EJ. A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies. Frontiers in Molecular Biosciences. 9: 783669. PMID 35252348 DOI: 10.3389/fmolb.2022.783669 |
0.343 |
|
| 2021 |
Chen E, Reiss K, Shah D, Manjula R, Allen B, Murphy EL, Murphy JW, Batista VS, Bhandari V, Lolis EJ, Lisi GP. A Structurally Preserved Allosteric Site in the MIF Superfamily Affects Enzymatic Activity and CD74 Activation in D-dopachrome Tautomerase. The Journal of Biological Chemistry. 101061. PMID 34384784 DOI: 10.1016/j.jbc.2021.101061 |
0.347 |
|
| 2020 |
Gannam ZTK, Min K, Shillingford SR, Zhang L, Herrington J, Abriola L, Gareiss PC, Pantouris G, Tzouvelekis A, Kaminski N, Zhang X, Yu J, Jamali H, Ellman JA, Lolis E, et al. An allosteric site on MKP5 reveals a strategy for small-molecule inhibition. Science Signaling. 13. PMID 32843541 DOI: 10.1126/Scisignal.Aba3043 |
0.37 |
|
| 2020 |
Murphy JW, Rajasekaran D, Merkel J, Skeens E, Keeler C, Hodsdon ME, Lisi GP, Lolis E. High-Throughput Screening of a Functional Human CXCL12-CXCR4 Signaling Axis in a Genetically Modified : Discovery of a Novel Up-Regulator of CXCR4 Activity. Frontiers in Molecular Biosciences. 7: 164. PMID 32766282 DOI: 10.3389/Fmolb.2020.00164 |
0.376 |
|
| 2019 |
Tilstam PV, Pantouris G, Corman M, Andreoli M, Mahboubi K, Davis G, Du X, Leng L, Lolis E, Bucala R. A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity. The Journal of Biological Chemistry. PMID 31578280 DOI: 10.1074/Jbc.Ra119.009860 |
0.446 |
|
| 2018 |
Pantouris G, Bucala R, Lolis EJ. Structural Plasticity at the C-terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective inhibitor. Biochemistry. PMID 29847104 DOI: 10.1021/Acs.Biochem.8B00344 |
0.327 |
|
| 2018 |
Lacy M, Kontos C, Brandhofer M, Hille K, Gröning S, Sinitski D, Bourilhon P, Rosenberg E, Krammer C, Thavayogarajah T, Pantouris G, Bakou M, Weber C, Lolis E, Bernhagen J, et al. Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4. Scientific Reports. 8: 5171. PMID 29581527 DOI: 10.1038/S41598-018-23554-5 |
0.446 |
|
| 2016 |
Meza-Romero R, Benedek G, Jordan K, Leng L, Pantouris G, Lolis E, Bucala R, Vandenbark AA. Modeling of both shared and distinct interactions between MIF and its homologue D-DT with their common receptor CD74. Cytokine. 88: 62-70. PMID 27573366 DOI: 10.1016/J.Cyto.2016.08.024 |
0.314 |
|
| 2016 |
Rajasekaran D, Gröning S, Schmitz C, Zierow S, Drucker N, Bakou M, Kohl K, Mertens A, Lue H, Weber C, Xiao A, Luker G, Kapurniotu A, Lolis EJ, Bernhagen J. Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: Evidence for Partial Allosteric Agonism in Comparison to CXCL12. The Journal of Biological Chemistry. PMID 27226569 DOI: 10.1074/jbc.M116.717751 |
0.326 |
|
| 2014 |
Pantouris G, Rajasekaran D, Garcia AB, Ruiz VG, Leng L, Jorgensen WL, Bucala R, Lolis EJ. Crystallographic and receptor binding characterization of Plasmodium falciparum macrophage migration inhibitory factor complexed to two potent inhibitors. Journal of Medicinal Chemistry. 57: 8652-6. PMID 25268646 DOI: 10.1021/Jm501168Q |
0.334 |
|
| 2013 |
Fan C, Rajasekaran D, Syed MA, Leng L, Loria JP, Bhandari V, Bucala R, Lolis EJ. MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proceedings of the National Academy of Sciences of the United States of America. 110: 10994-9. PMID 23776208 DOI: 10.1073/Pnas.1221817110 |
0.338 |
|
| 2012 |
Crichlow GV, Fan C, Keeler C, Hodsdon M, Lolis EJ. Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates. Biochemistry. 51: 7506-14. PMID 22931430 DOI: 10.1021/Bi3005494 |
0.3 |
|
| 2012 |
Rajasekaran D, Keeler C, Syed MA, Jones MC, Harrison JK, Wu D, Bhandari V, Hodsdon ME, Lolis EJ. A model of GAG/MIP-2/CXCR2 interfaces and its functional effects. Biochemistry. 51: 5642-54. PMID 22686371 DOI: 10.1021/Bi3001566 |
0.324 |
|
| 2011 |
Cho Y, Vermeire JJ, Merkel JS, Leng L, Du X, Bucala R, Cappello M, Lolis E. Drug repositioning and pharmacophore identification in the discovery of hookworm MIF inhibitors. Chemistry & Biology. 18: 1089-101. PMID 21944748 DOI: 10.1016/J.Chembiol.2011.07.011 |
0.388 |
|
| 2011 |
Merk M, Zierow S, Leng L, Das R, Du X, Schulte W, Fan J, Lue H, Chen Y, Xiong H, Chagnon F, Bernhagen J, Lolis E, Mor G, Lesur O, et al. The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proceedings of the National Academy of Sciences of the United States of America. 108: E577-85. PMID 21817065 DOI: 10.1073/Pnas.1102941108 |
0.357 |
|
| 2011 |
Leng L, Chen L, Fan J, Greven D, Arjona A, Du X, Austin D, Kashgarian M, Yin Z, Huang XR, Lan HY, Lolis E, Nikolic-Paterson D, Bucala R. A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice. Journal of Immunology (Baltimore, Md. : 1950). 186: 527-38. PMID 21106847 DOI: 10.4049/Jimmunol.1001767 |
0.382 |
|
| 2010 |
Cho Y, Crichlow GV, Vermeire JJ, Leng L, Du X, Hodsdon ME, Bucala R, Cappello M, Gross M, Gaeta F, Johnson K, Lolis EJ. Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proceedings of the National Academy of Sciences of the United States of America. 107: 11313-8. PMID 20534506 DOI: 10.1073/Pnas.1002716107 |
0.354 |
|
| 2009 |
Crichlow GV, Lubetsky JB, Leng L, Bucala R, Lolis EJ. Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions. Biochemistry. 48: 132-9. PMID 19090677 DOI: 10.1021/Bi8014423 |
0.805 |
|
| 2008 |
Winner M, Meier J, Zierow S, Rendon BE, Crichlow GV, Riggs R, Bucala R, Leng L, Smith N, Lolis E, Trent JO, Mitchell RA. A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Research. 68: 7253-7. PMID 18794110 DOI: 10.1158/0008-5472.Can-07-6227 |
0.443 |
|
| 2008 |
Kamir D, Zierow S, Leng L, Cho Y, Diaz Y, Griffith J, McDonald C, Merk M, Mitchell RA, Trent J, Chen Y, Kwong YK, Xiong H, Vermeire J, Cappello M, ... ... Lolis E, et al. A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses. Journal of Immunology (Baltimore, Md. : 1950). 180: 8250-61. PMID 18523291 DOI: 10.4049/Jimmunol.180.12.8250 |
0.441 |
|
| 2008 |
Zhang W, Cho Y, Lolis E, Howe JR. Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 932-43. PMID 18216201 DOI: 10.1523/Jneurosci.3309-07.2008 |
0.3 |
|
| 2008 |
Crichlow GV, Zhou H, Hsiao HH, Frederick KB, Debrosse M, Yang Y, Folta-Stogniew EJ, Chung HJ, Fan C, De la Cruz EM, Levens D, Lolis E, Braddock D. Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition. The Embo Journal. 27: 277-89. PMID 18059478 DOI: 10.1038/Sj.Emboj.7601936 |
0.34 |
|
| 2007 |
Cho Y, Jones BF, Vermeire JJ, Leng L, DiFedele L, Harrison LM, Xiong H, Kwong YK, Chen Y, Bucala R, Lolis E, Cappello M. Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74. The Journal of Biological Chemistry. 282: 23447-56. PMID 17567581 DOI: 10.1074/Jbc.M702950200 |
0.458 |
|
| 2007 |
Crichlow GV, Cheng KF, Dabideen D, Ochani M, Aljabari B, Pavlov VA, Miller EJ, Lolis E, Al-Abed Y. Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. The Journal of Biological Chemistry. 282: 23089-95. PMID 17526494 DOI: 10.1074/Jbc.M701825200 |
0.473 |
|
| 2007 |
Murphy JW, Cho Y, Sachpatzidis A, Fan C, Hodsdon ME, Lolis E. Structural and functional basis of CXCL12 (stromal cell-derived factor-1 alpha) binding to heparin. The Journal of Biological Chemistry. 282: 10018-27. PMID 17264079 DOI: 10.1074/Jbc.M608796200 |
0.778 |
|
| 2005 |
Bucala R, Lolis E. Macrophage migration inhibitory factor: a critical component of autoimmune inflammatory diseases. Drug News & Perspectives. 18: 417-26. PMID 16362080 DOI: 10.1358/Dnp.2005.18.7.939345 |
0.317 |
|
| 2005 |
Wilson JM, Coletta PL, Cuthbert RJ, Scott N, MacLennan K, Hawcroft G, Leng L, Lubetsky JB, Jin KK, Lolis E, Medina F, Brieva JA, Poulsom R, Markham AF, Bucala R, et al. Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Gastroenterology. 129: 1485-503. PMID 16285950 DOI: 10.1053/J.Gastro.2005.07.061 |
0.751 |
|
| 2003 |
Scheuermann TH, Lolis E, Hodsdon ME. Tertiary structure of thiopurine methyltransferase from Pseudomonas syringae, a bacterial orthologue of a polymorphic, drug-metabolizing enzyme. Journal of Molecular Biology. 333: 573-85. PMID 14556746 DOI: 10.1016/J.Jmb.2003.08.039 |
0.773 |
|
| 2003 |
Lolis E, Bucala R. Macrophage migration inhibitory factor. Expert Opinion On Therapeutic Targets. 7: 153-64. PMID 12667094 DOI: 10.1517/14728222.7.2.153 |
0.457 |
|
| 2003 |
Sachpatzidis A, Benton BK, Manfredi JP, Wang H, Hamilton A, Dohlman HG, Lolis E. Identification of allosteric peptide agonists of CXCR4. The Journal of Biological Chemistry. 278: 896-907. PMID 12417595 DOI: 10.1074/Jbc.M204667200 |
0.752 |
|
| 2002 |
Dios A, Mitchell RA, Aljabari B, Lubetsky J, O'Connor K, Liao H, Senter PD, Manogue KR, Lolis E, Metz C, Bucala R, Callaway DJ, Al-Abed Y. Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity. Journal of Medicinal Chemistry. 45: 2410-6. PMID 12036350 DOI: 10.1021/Jm010534Q |
0.796 |
|
| 2002 |
Wang D, Sai J, Carter G, Sachpatzidis A, Lolis E, Richmond A. PAK1 kinase is required for CXCL1-induced chemotaxis. Biochemistry. 41: 7100-7. PMID 12033944 DOI: 10.1021/Bi025902M |
0.769 |
|
| 2002 |
Lubetsky JB, Dios A, Han J, Aljabari B, Ruzsicska B, Mitchell R, Lolis E, Al-Abed Y. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. The Journal of Biological Chemistry. 277: 24976-82. PMID 11997397 DOI: 10.1074/Jbc.M203220200 |
0.794 |
|
| 2002 |
Fernandez EJ, Lolis E. Structure, function, and inhibition of chemokines. Annual Review of Pharmacology and Toxicology. 42: 469-99. PMID 11807180 DOI: 10.1146/Annurev.Pharmtox.42.091901.115838 |
0.421 |
|
| 2001 |
Lolis E. Glucocorticoid counter regulation: Macrophage migration inhibitory factor as a target for drug discovery Current Opinion in Pharmacology. 1: 662-668. PMID 11757824 DOI: 10.1016/S1471-4892(01)00112-6 |
0.402 |
|
| 2001 |
de Jong YP, Abadia-Molina AC, Satoskar AR, Clarke K, Rietdijk ST, Faubion WA, Mizoguchi E, Metz CN, Alsahli M, ten Hove T, Keates AC, Lubetsky JB, Farrell RJ, Michetti P, van Deventer SJ, ... Lolis E, et al. Development of chronic colitis is dependent on the cytokine MIF. Nature Immunology. 2: 1061-6. PMID 11668338 DOI: 10.1038/Ni720 |
0.745 |
|
| 2001 |
Shao W, Fernandez E, Sachpatzidis A, Wilken J, Thompson DA, Schweitzer BI, Lolis E. CCR2 and CCR5 receptor-binding properties of herpesvirus-8 vMIP-II based on sequence analysis and its solution structure. European Journal of Biochemistry / Febs. 268: 2948-59. PMID 11358512 DOI: 10.1046/J.1432-1327.2001.02184.X |
0.767 |
|
| 2000 |
Fernandez EJ, Wilken J, Thompson DA, Peiper SC, Lolis E. Comparison of the structure of vMIP-II with eotaxin-1, RANTES, and MCP-3 suggests a unique mechanism for CCR3 activation Biochemistry. 39: 12837-12844. PMID 11041848 DOI: 10.1021/Bi001166F |
0.343 |
|
| 1999 |
Sachpatzidis A, Dealwis C, Lubetsky JB, Liang PH, Anderson KS, Lolis E. Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase. Biochemistry. 38: 12665-74. PMID 10504236 DOI: 10.1021/Bi9907734 |
0.724 |
|
| 1999 |
Swope MD, Lolis E. Macrophage migration inhibitory factor: cytokine, hormone, or enzyme? Reviews of Physiology, Biochemistry and Pharmacology. 139: 1-32. PMID 10453691 DOI: 10.1007/Bfb0033647 |
0.37 |
|
| 1999 |
Lubetsky JB, Swope M, Dealwis C, Blake P, Lolis E. Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity. Biochemistry. 38: 7346-54. PMID 10353846 DOI: 10.1021/Bi990306M |
0.795 |
|
| 1998 |
Shao W, Fernandez E, Wilken J, Thompson DA, Siani MA, West J, Lolis E, Schweitzer BI. Accessibility of selenomethionine proteins by total chemical synthesis: Structural studies of human herpesvirus-8 MIP-II Febs Letters. 441: 77-82. PMID 9877169 DOI: 10.1016/S0014-5793(98)01520-8 |
0.342 |
|
| 1998 |
Swope M, Sun HW, Blake PR, Lolis E. Direct link between cytokine activity and a catalytic site for macrophage migration inhibitory factor. The Embo Journal. 17: 3534-41. PMID 9649424 DOI: 10.1093/Emboj/17.13.3534 |
0.502 |
|
| 1998 |
Shao W, Jerva LF, West J, Lolis E, Schweitzer BI. Solution structure of murine macrophage inflammatory protein-2 Biochemistry. 37: 8303-8313. PMID 9622482 DOI: 10.1021/Bi980112R |
0.359 |
|
| 1998 |
Dealwis C, Fernandez EJ, Thompson DA, Simon RJ, Siani MA, Lolis E. Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor. Proceedings of the National Academy of Sciences of the United States of America. 95: 6941-6. PMID 9618518 DOI: 10.1073/Pnas.95.12.6941 |
0.332 |
|
| 1998 |
Swope MD, Sun HW, Klockow B, Blake P, Lolis E. Macrophage migration inhibitory factor interactions with glutathione and S-hexylglutathione. The Journal of Biological Chemistry. 273: 14877-84. PMID 9614090 DOI: 10.1074/Jbc.273.24.14877 |
0.404 |
|
| 1996 |
Sun HW, Swope M, Cinquina C, Bedarkar S, Bernhagen J, Bucala R, Lolis E. The subunit structure of human macrophage migration inhibitory factor: Evidence for a trimer Protein Engineering. 9: 631-635. PMID 8875640 DOI: 10.1093/Protein/9.8.631 |
0.331 |
|
| 1996 |
Sun HW, Bernhagen J, Bucala R, Lolis E. Crystal structure at 2.6-Å resolution of human macrophage migration inhibitory factor Proceedings of the National Academy of Sciences of the United States of America. 93: 5191-5196. PMID 8643551 DOI: 10.1073/Pnas.93.11.5191 |
0.368 |
|
| 1994 |
Joseph-McCarthy D, Lolis E, Komives EA, Petsko GA. Crystal structure of the K12M/G15A triosephosphate isomerase double mutant and electrostatic analysis of the active site. Biochemistry. 33: 2815-23. PMID 8130194 DOI: 10.1021/Bi00176A010 |
0.582 |
|
| 1993 |
Petsko G, Ringe D, Allen K, Lavie A, Gerhart-Mueller E, Clifton J, Hasson M, Fujita S, Sugio S, Xhang X, Davenport R, Lolis E, Neidhart D, Kenyon G, Gerlt J, et al. The structural enzymology of proton-transfer reactions Protein Engineering, Design and Selection. 6: 37. DOI: 10.1093/Protein/6.Supplement.37-A |
0.712 |
|
| 1992 |
Lolis E, Sweet RM, Cousens LS, Tekamp-Olson P, Sherry BA, Cerami A. Preliminary crystallographic analysis of murine macrophage inflammatory protein 2 Journal of Molecular Biology. 225: 913-915. PMID 1602491 DOI: 10.1016/0022-2836(92)90411-C |
0.308 |
|
| 1991 |
Komives EA, Chang LC, Lolis E, Tilton RF, Petsko GA, Knowles JR. Electrophilic catalysis in triosephosphate isomerase: the role of histidine-95. Biochemistry. 30: 3011-9. PMID 2007138 DOI: 10.1021/Bi00226A005 |
0.545 |
|
| 1990 |
Lolis E. Crystallographic analysis of the complex between triosephosphate isomerase and 2-phosphoglycolate at 2.5-Å resolution: Implications for catalysis Biochemistry®. 29: 6619-6625. PMID 2204418 DOI: 10.1021/Bi00480A010 |
0.43 |
|
| 1990 |
Lolis E. Structure of yeast triosephosphate isomerase at 1.9-Å resolution Biochemistry®. 29: 6609-6618. PMID 2204417 DOI: 10.1021/Bi00480A009 |
0.435 |
|
| 1990 |
Lolis E, Petsko GA. Transition-state analogues in protein crystallography: probes of the structural source of enzyme catalysis. Annual Review of Biochemistry. 59: 597-630. PMID 2197984 DOI: 10.1146/Annurev.Bi.59.070190.003121 |
0.508 |
|
| 1987 |
Alber TC, Davenport RC, Giammona DA, Lolis E, Petsko GA, Ringe D. Crystallography and site-directed mutagenesis of yeast triosephosphate isomerase: what can we learn about catalysis from a "simple" enzyme? Cold Spring Harbor Symposia On Quantitative Biology. 52: 603-13. PMID 3331346 DOI: 10.1101/Sqb.1987.052.01.069 |
0.651 |
|
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