| Year |
Citation |
Score |
| 2023 |
Proffitt MR, Liu X, Ortlund EA, Smith GT. Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes. Molecular and Cellular Endocrinology. 112068. PMID 37714403 DOI: 10.1016/j.mce.2023.112068 |
0.307 |
|
| 2023 |
Mays SG, Hercules D, Ortlund EA, Okafor CD. The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits. Protein Science : a Publication of the Protein Society. e4754. PMID 37572334 DOI: 10.1002/pro.4754 |
0.653 |
|
| 2023 |
Cato ML, D'Agostino EH, Spurlin RM, Flynn AR, Cornelison JL, Johnson AM, Fujita RA, Abraham SM, Jui NT, Ortlund EA. Comparison of Activity, Structure, and Dynamics of SF-1 and LRH-1 Complexed with Small Molecule Modulators. The Journal of Biological Chemistry. 104921. PMID 37328104 DOI: 10.1016/j.jbc.2023.104921 |
0.394 |
|
| 2023 |
Mays SG, Hercules D, Ortlund EA, Okafor CD. The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits. Biorxiv : the Preprint Server For Biology. PMID 36747705 DOI: 10.1101/2023.01.27.525934 |
0.652 |
|
| 2022 |
Cato ML, Cornelison JL, Spurlin RM, Courouble VV, Patel AB, Flynn AR, Johnson AM, Okafor CD, Frank F, D'Agostino EH, Griffin PR, Jui NT, Ortlund EA. Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket. Journal of Medicinal Chemistry. PMID 35503419 DOI: 10.1021/acs.jmedchem.2c00235 |
0.665 |
|
| 2022 |
Mays SG, D'Agostino EH, Flynn AR, Huang X, Wang G, Liu X, Millings EJ, Okafor CD, Patel A, Cato ML, Cornelison JL, Melchers D, Houtman R, Moore DD, Calvert JW, ... ... Ortlund EA, et al. A phospholipid mimetic targeting LRH-1 ameliorates colitis. Cell Chemical Biology. PMID 35316658 DOI: 10.1016/j.chembiol.2022.03.001 |
0.671 |
|
| 2021 |
Frank F, Ortlund EA, Liu X. Structural insights into glucocorticoid receptor function. Biochemical Society Transactions. PMID 34709368 DOI: 10.1042/BST20210419 |
0.316 |
|
| 2021 |
Frank F, Liu X, Ortlund EA. Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34285072 DOI: 10.1073/pnas.2024685118 |
0.358 |
|
| 2021 |
Bruno NE, Nwachukwu JC, Srinivasan S, Nettles CC, Izard T, Jin Z, Nowak J, Cameron MD, Boregowda SV, Phinney DG, Elemento O, Liu X, Ortlund EA, Houtman R, Stavreva DA, et al. Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling. Nature Chemical Biology. PMID 33510451 DOI: 10.1038/s41589-020-00719-w |
0.338 |
|
| 2020 |
Mays SG, Stec J, Liu X, D'Agostino EH, Whitby RJ, Ortlund EA. Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist. Scientific Reports. 10: 22279. PMID 33335203 DOI: 10.1038/s41598-020-79251-9 |
0.377 |
|
| 2020 |
Moody JC, Qadota H, Reedy AR, Okafor CD, Shanmugan N, Matsunaga Y, Christian CJ, Ortlund EA, Benian GM. The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells. Nature Communications. 11: 5010. PMID 33024114 DOI: 10.1038/s41467-020-18852-4 |
0.518 |
|
| 2020 |
Liu X, Wang Y, Gutierrez JS, Damsker JM, Nagaraju K, Hoffman EP, Ortlund EA. Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment. Proceedings of the National Academy of Sciences of the United States of America. PMID 32917814 DOI: 10.1073/Pnas.2006890117 |
0.407 |
|
| 2020 |
Tillman MC, Imai N, Li Y, Khadka M, Okafor CD, Juneja P, Adhiyaman A, Hagen SJ, Cohen DE, Ortlund EA. Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine. Proceedings of the National Academy of Sciences of the United States of America. PMID 32820071 DOI: 10.1073/Pnas.2003877117 |
0.608 |
|
| 2020 |
Frank F, Kavousi N, Bountali A, Dammer EB, Mourtada-Maarabouni M, Ortlund EA. The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions. Cell Reports. 32: 107933. PMID 32697996 DOI: 10.1016/J.Celrep.2020.107933 |
0.336 |
|
| 2020 |
Cornelison JL, Cato ML, Johnson AM, D'Agostino EH, Melchers D, Patel AB, Mays SG, Houtman R, Ortlund EA, Jui NT. Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition. Bioorganic & Medicinal Chemistry Letters. 30: 127293. PMID 32631515 DOI: 10.1016/J.Bmcl.2020.127293 |
0.484 |
|
| 2020 |
D'Agostino EH, Flynn AR, Cornelison JL, Mays SG, Patel A, Jui NT, Ortlund EA. Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors. Acs Medicinal Chemistry Letters. 11: 365-370. PMID 32184971 DOI: 10.1021/Acsmedchemlett.9B00442 |
0.489 |
|
| 2020 |
Druzak SA, Mays S, Ortlund E. SAT-LB124 Phosphatidylcholine Transfer Protein Interacts With PPARδ to Modulate Activity Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.2334 |
0.401 |
|
| 2020 |
Frank F, Kavousi N, Bountali A, Dammer E, Mourtada-Maarabouni M, Ortlund E. SAT-LB138 The LncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules With Independent Functions Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.2327 |
0.366 |
|
| 2020 |
Tillman MC, Li Y, Khadka MC, Imai N, Adhiyaman AC, Juneja PC, Hagen SJ, Cohen DE, Ortlund EA. Them1 Binds to Free Fatty Acids and is Allosterically Regulated by Lysophosphatidylcholine to Control Fatty Acyl‐CoA Hydrolysis in Brown Adipose Tissue The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07311 |
0.328 |
|
| 2020 |
Baqai M, Li Y, Tillman M, Ortlund EA, Cohen DE, Hagen SJ. The Them1 START Domain Regulates Nuclear Trafficking in Brown Adipocytes The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04590 |
0.302 |
|
| 2020 |
Cato ML, Cornelison J, Flynn A, D’Agostino E, Jui N, Ortlund E. Development of picomolar liver receptor homolog‐1 agonist The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02884 |
0.351 |
|
| 2019 |
Okafor CD, Hercules D, Kell SA, Ortlund EA. Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors. Structure (London, England : 1993). PMID 31831214 DOI: 10.1016/J.Str.2019.11.012 |
0.641 |
|
| 2019 |
Mays S, Flynn AR, Cornelison J, Okafor CD, Wang H, Wang G, Huang X, Donaldson H, Millings E, Polavarapu R, Moore D, Calvert J, Jui NT, Ortlund EA. Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design. Journal of Medicinal Chemistry. PMID 31419141 DOI: 10.1021/Acs.Jmedchem.9B00753 |
0.664 |
|
| 2019 |
Liu X, Wang Y, Ortlund EA. First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-PGC1lower case Greek alpha Complex with Endogenous and Synthetic Glucocorticoids. Molecular Pharmacology. PMID 31391291 DOI: 10.1124/Mol.119.116806 |
0.512 |
|
| 2019 |
Tillman MC, Khadka M, Duffy J, Wang MC, Ortlund EA. Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8. Scientific Reports. 9: 9966. PMID 31292465 DOI: 10.1038/S41598-019-46230-8 |
0.476 |
|
| 2019 |
Okafor CD, Colucci JK, Ortlund EA. Ligand-Induced Allosteric Effects Governing SR Signaling Nuclear Receptor Research. 6. DOI: 10.32527/2019/101382 |
0.706 |
|
| 2018 |
Flynn AR, Mays SG, Ortlund EA, Jui NT. Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1. Acs Medicinal Chemistry Letters. 9: 1051-1056. PMID 30344916 DOI: 10.1021/Acsmedchemlett.8B00361 |
0.463 |
|
| 2018 |
Frank F, Okafor CD, Ortlund EA. The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor. Scientific Reports. 8: 13497. PMID 30201977 DOI: 10.1038/S41598-018-31812-9 |
0.66 |
|
| 2018 |
Weikum ER, Liu X, Ortlund EA. The nuclear receptor superfamily: A structural perspective. Protein Science : a Publication of the Protein Society. PMID 30109749 DOI: 10.1002/Pro.3496 |
0.474 |
|
| 2018 |
Hudson WH, Vera IMS, Nwachukwu JC, Weikum ER, Herbst AG, Yang Q, Bain DL, Nettles KW, Kojetin DJ, Ortlund EA. Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements. Nature Communications. 9: 1337. PMID 29626214 DOI: 10.1038/S41467-018-03780-1 |
0.416 |
|
| 2018 |
Okafor CD, Pathak MC, Fagan CE, Bauer NC, Cole MF, Gaucher EA, Ortlund EA. Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus. Structure (London, England : 1993). 26: 118-129.e3. PMID 29276038 DOI: 10.1016/J.Str.2017.11.018 |
0.6 |
|
| 2017 |
Weikum ER, de Vera IMS, Nwachukwu JC, Hudson WH, Nettles KW, Kojetin DJ, Ortlund EA. Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes. Nucleic Acids Research. PMID 28591827 DOI: 10.1093/Nar/Gkx509 |
0.456 |
|
| 2017 |
Weikum ER, Okafor DC, D'Agostino EH, Colucci JK, Ortlund EA. Structural analysis of the glucocorticoid receptor ligand-binding domain in complex with triamcinolone acetonide and a fragment of the atypical coregulator, SHP. Molecular Pharmacology. PMID 28396564 DOI: 10.1124/Mol.117.108506 |
0.535 |
|
| 2017 |
Mays SG, Okafor CD, Tuntland ML, Whitby RJ, Dharmarajan V, Stec J, Griffin PR, Ortlund EA. Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex. Molecular Pharmacology. PMID 28363985 DOI: 10.1124/Mol.117.108514 |
0.702 |
|
| 2017 |
Weikum ER, Knuesel MT, Ortlund EA, Yamamoto KR. Glucocorticoid receptor control of transcription: precision and plasticity via allostery. Nature Reviews. Molecular Cell Biology. PMID 28053348 DOI: 10.1038/Nrm.2016.152 |
0.408 |
|
| 2017 |
Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec J, Flynn AR, Dugan MC, Jui NT, Griffin PR, Ortlund EA. Targeting the nuclear receptor LRH-1 with synthetic agonists Acta Crystallographica Section a Foundations and Advances. 73: a98-a98. DOI: 10.1107/S0108767317099020 |
0.616 |
|
| 2016 |
Weikum ER, Tuntland ML, Murphy MN, Ortlund EA. A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF) and Liver Receptor Homolog-1 (LRH-1). Journal of Molecular Biology. PMID 27984042 DOI: 10.1016/J.Jmb.2016.10.025 |
0.458 |
|
| 2016 |
Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec JO, Flynn AR, Dugan MC, Jui NT, Griffin PR, Ortlund EA. Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of Activation. The Journal of Biological Chemistry. PMID 27694446 DOI: 10.1074/Jbc.M116.753541 |
0.715 |
|
| 2016 |
Musille PM, Kossmann BR, Kohn JA, Ivanov I, Ortlund EA. Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity. The Journal of Biological Chemistry. 291: 1411-26. PMID 26553876 DOI: 10.1074/Jbc.M115.662874 |
0.532 |
|
| 2015 |
Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proceedings of the National Academy of Sciences of the United States of America. PMID 26715749 DOI: 10.1073/Pnas.1518960113 |
0.467 |
|
| 2015 |
Yu K, Whitlock JM, Lee K, Ortlund EA, Yuan Cui Y, Hartzell HC. Identification of a lipid scrambling domain in ANO6/TMEM16F. Elife. 4. PMID 26057829 DOI: 10.7554/Elife.06901 |
0.301 |
|
| 2015 |
Brown NE, Goswami D, Branch MR, Ramineni S, Ortlund EA, Griffin PR, Hepler JR. Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14). The Journal of Biological Chemistry. 290: 9037-49. PMID 25666614 DOI: 10.1074/Jbc.M114.634329 |
0.405 |
|
| 2015 |
Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC. Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. Science (New York, N.Y.). 347: 83-6. PMID 25554789 DOI: 10.1126/Science.1258857 |
0.382 |
|
| 2014 |
Hudson WH, Pickard MR, de Vera IM, Kuiper EG, Mourtada-Maarabouni M, Conn GL, Kojetin DJ, Williams GT, Ortlund EA. Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate. Nature Communications. 5: 5395. PMID 25377354 DOI: 10.1038/Ncomms6395 |
0.389 |
|
| 2014 |
Hudson WH, Ortlund EA. The structure, function and evolution of proteins that bind DNA and RNA. Nature Reviews. Molecular Cell Biology. 15: 749-60. PMID 25269475 DOI: 10.1038/Nrm3884 |
0.369 |
|
| 2014 |
McKeown AN, Bridgham JT, Anderson DW, Murphy MN, Ortlund EA, Thornton JW. Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module. Cell. 159: 58-68. PMID 25259920 DOI: 10.1016/J.Cell.2014.09.003 |
0.422 |
|
| 2014 |
Hudson WH, Youn C, Ortlund EA. Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. Plos One. 9: e107000. PMID 25188500 DOI: 10.1371/Journal.Pone.0107000 |
0.478 |
|
| 2014 |
Armstrong EH, Goswami D, Griffin PR, Noy N, Ortlund EA. Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway. The Journal of Biological Chemistry. 289: 14941-54. PMID 24692551 DOI: 10.1074/Jbc.M113.514646 |
0.425 |
|
| 2014 |
Musille P, Ortlund E. Structure of glycerol dehydrogenase from Serratia. Acta Crystallographica. Section F, Structural Biology Communications. 70: 166-72. PMID 24637749 DOI: 10.1107/S2053230X13034444 |
0.315 |
|
| 2014 |
Kratzer JT, Lanaspa MA, Murphy MN, Cicerchi C, Graves CL, Tipton PA, Ortlund EA, Johnson RJ, Gaucher EA. Evolutionary history and metabolic insights of ancient mammalian uricases Proceedings of the National Academy of Sciences of the United States of America. 111: 3763-3768. PMID 24550457 DOI: 10.1073/Pnas.1320393111 |
0.331 |
|
| 2014 |
Bridgham JT, Keay J, Ortlund EA, Thornton JW. Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor. Plos Genetics. 10: e1004058. PMID 24415950 DOI: 10.1371/Journal.Pgen.1004058 |
0.501 |
|
| 2014 |
Ren J, Pei-Chen Lin C, Pathak MC, Temple BR, Nile AH, Mousley CJ, Duncan MC, Eckert DM, Leiker TJ, Ivanova PT, Myers DS, Murphy RC, Brown HA, Verdaasdonk J, Bloom KS, ... Ortlund EA, et al. A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis. Molecular Biology of the Cell. 25: 712-27. PMID 24403601 DOI: 10.1091/Mbc.E13-11-0634 |
0.336 |
|
| 2014 |
Armstrong EH, Goswami D, Griffin PR, Noy N, Ortlund E. Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta / delta (FABP5-PPAR beta / delta ) signaling pathway. Journal of Biological Chemistry. 289: 14941-14954. DOI: 10.2210/Pdb4Lkp/Pdb |
0.417 |
|
| 2013 |
Colucci JK, Ortlund EA. X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface. Plos One. 8: e80761. PMID 24260475 DOI: 10.1371/Journal.Pone.0080761 |
0.547 |
|
| 2013 |
Colucci JK, Ortlund EA. Expression, purification and crystallization of the ancestral androgen receptor-DHT complex. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 994-6. PMID 23989146 DOI: 10.1107/S1744309113018745 |
0.477 |
|
| 2013 |
Harms MJ, Eick GN, Goswami D, Colucci JK, Griffin PR, Ortlund EA, Thornton JW. Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors. Proceedings of the National Academy of Sciences of the United States of America. 110: 11475-80. PMID 23798447 DOI: 10.1073/Pnas.1303930110 |
0.426 |
|
| 2013 |
Musille PM, Pathak M, Lauer JL, Griffin PR, Ortlund EA. Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors Journal of Biological Chemistry. 288: 20702-20712. PMID 23737522 DOI: 10.1074/Jbc.M113.472837 |
0.509 |
|
| 2013 |
Musille PM, Kohn JA, Ortlund EA. Phospholipid--driven gene regulation. Febs Letters. 587: 1238-46. PMID 23333623 DOI: 10.1016/J.Febslet.2013.01.004 |
0.353 |
|
| 2013 |
Hudson WH, Youn C, Ortlund EA. The structural basis of direct glucocorticoid-mediated transrepression. Nature Structural & Molecular Biology. 20: 53-8. PMID 23222642 DOI: 10.1038/Nsmb.2456 |
0.46 |
|
| 2012 |
Eick GN, Colucci JK, Harms MJ, Ortlund EA, Thornton JW. Evolution of minimal specificity and promiscuity in steroid hormone receptors. Plos Genetics. 8: e1003072. PMID 23166518 DOI: 10.1371/Journal.Pgen.1003072 |
0.489 |
|
| 2012 |
Rey J, Hu H, Kyle F, Lai CF, Buluwela L, Coombes RC, Ortlund EA, Ali S, Snyder JP, Barrett AG. Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation. Chemmedchem. 7: 1909-14. PMID 22961990 DOI: 10.1002/Cmdc.201200307 |
0.412 |
|
| 2012 |
Musille PM, Pathak MC, Lauer JL, Hudson WH, Griffin PR, Ortlund EA. Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation. Nature Structural & Molecular Biology. 19: 532-7, S1-2. PMID 22504882 DOI: 10.1038/Nsmb.2279 |
0.483 |
|
| 2012 |
Kohn JA, Deshpande K, Ortlund EA. Deciphering modern glucocorticoid cross-pharmacology using ancestral corticosteroid receptors. The Journal of Biological Chemistry. 287: 16267-75. PMID 22437833 DOI: 10.1074/Jbc.M112.346411 |
0.521 |
|
| 2012 |
Rey J, Hu H, Kyle F, Lai C, Buluwela L, Coombes RC, Ortlund EA, Ali S, Snyder JP, Barrett AGM. Back Cover: Discovery of a New Class of Liver Receptor Homolog-1 (LRH-1) Antagonists: Virtual Screening, Synthesis and Biological Evaluation (ChemMedChem 11/2012) Chemmedchem. 7: 2044-2044. DOI: 10.1002/Cmdc.201290058 |
0.325 |
|
| 2011 |
Ren J, Schaaf G, Bankaitis VA, Ortlund EA, Pathak MC. Crystallization and preliminary X-ray diffraction analysis of Sfh3, a member of the Sec14 protein superfamily. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1239-43. PMID 22102037 DOI: 10.1107/S1744309111027096 |
0.385 |
|
| 2011 |
Carroll SM, Ortlund EA, Thornton JW. Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor. Plos Genetics. 7: e1002117. PMID 21698144 DOI: 10.1371/Journal.Pgen.1002117 |
0.41 |
|
| 2011 |
Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, Pathak MC, Ortlund EA, Moore DD. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature. 474: 506-10. PMID 21614002 DOI: 10.1038/Nature10111 |
0.394 |
|
| 2011 |
Schaaf G, Dynowski M, Mousley CJ, Shah SD, Yuan P, Winklbauer EM, de Campos MK, Trettin K, Quinones MC, Smirnova TI, Yanagisawa LL, Ortlund EA, Bankaitis VA. Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution. Molecular Biology of the Cell. 22: 892-905. PMID 21248202 DOI: 10.1091/Mbc.E10-11-0903 |
0.438 |
|
| 2011 |
Thiruchelvam PT, Lai CF, Hua H, Thomas RS, Hurtado A, Hudson W, Bayly AR, Kyle FJ, Periyasamy M, Photiou A, Spivey AC, Ortlund EA, Whitby RJ, Carroll JS, Coombes RC, et al. The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells. Breast Cancer Research and Treatment. 127: 385-96. PMID 20607599 DOI: 10.1007/S10549-010-0994-9 |
0.326 |
|
| 2010 |
Bridgham JT, Eick GN, Larroux C, Deshpande K, Harms MJ, Gauthier ME, Ortlund EA, Degnan BM, Thornton JW. Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor. Plos Biology. 8. PMID 20957188 DOI: 10.1371/Journal.Pbio.1000497 |
0.5 |
|
| 2010 |
Chen F, Gaucher EA, Leal NA, Hutter D, Havemann SA, Govindarajan S, Ortlund EA, Benner SA. Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection. Proceedings of the National Academy of Sciences of the United States of America. 107: 1948-53. PMID 20080675 DOI: 10.1073/Pnas.0908463107 |
0.32 |
|
| 2009 |
Bridgham JT, Ortlund EA, Thornton JW. An epistatic ratchet constrains the direction of glucocorticoid receptor evolution. Nature. 461: 515-9. PMID 19779450 DOI: 10.1038/Nature08249 |
0.394 |
|
| 2008 |
Schaaf G, Ortlund EA, Tyeryar KR, Mousley CJ, Ile KE, Garrett TA, Ren J, Woolls MJ, Raetz CR, Redinbo MR, Bankaitis VA. Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily. Molecular Cell. 29: 191-206. PMID 18243114 DOI: 10.1016/J.Molcel.2007.11.026 |
0.633 |
|
| 2007 |
Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW. Crystal structure of an ancient protein: evolution by conformational epistasis. Science (New York, N.Y.). 317: 1544-8. PMID 17702911 DOI: 10.1126/Science.1142819 |
0.644 |
|
| 2007 |
Chiswell B, Lovelace LL, Brannen C, Ortlund EA, Lebioda L, Sodetz JM. Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family. Biochimica Et Biophysica Acta. 1774: 637-44. PMID 17452033 DOI: 10.1016/J.Bbapap.2007.03.004 |
0.776 |
|
| 2005 |
Solomon IH, Hager JM, Safi R, McDonnell DP, Redinbo MR, Ortlund EA. Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. Journal of Molecular Biology. 354: 1091-102. PMID 16289203 DOI: 10.1016/J.Jmb.2005.10.009 |
0.651 |
|
| 2005 |
Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nature Structural & Molecular Biology. 12: 357-63. PMID 15723037 DOI: 10.1038/Nsmb910 |
0.688 |
|
| 2003 |
Chruszcz M, Laidler P, Monkiewicz M, Ortlund E, Lebioda L, Lewinski K. Crystal structure of a covalent intermediate of endogenous human arylsulfatase A. Journal of Inorganic Biochemistry. 96: 386-92. PMID 12888274 DOI: 10.1016/S0162-0134(03)00176-4 |
0.587 |
|
| 2003 |
Ortlund E, LaCount MW, Lebioda L. Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design. Biochemistry. 42: 383-9. PMID 12525165 DOI: 10.1021/Bi0265067 |
0.619 |
|
| 2002 |
Ortlund E, Parker CL, Schreck SF, Ginell S, Minor W, Sodetz JM, Lebioda L. Crystal structure of human complement protein C8γ at 1.2 Å resolution reveals a lipocalin fold and a distinct ligand binding site Biochemistry. 41: 7030-7037. PMID 12033936 DOI: 10.1021/Bi025696I |
0.678 |
|
| 2000 |
Ortlund E, Lacount MW, Lewinski K, Lebioda L. Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu. Biochemistry. 39: 1199-204. PMID 10684596 DOI: 10.1021/Bi991797D |
0.566 |
|
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