| Year |
Citation |
Score |
| 2024 |
Choi S, Kang JG, Tran YTH, Jeong SH, Park KY, Shin H, Kim YH, Park M, Nahmgoong H, Seol T, Jeon H, Kim Y, Park S, Kim HJ, Kim MS, ... ... Moore DD, et al. Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass. Nature Metabolism. 6: 847-860. PMID 38811804 DOI: 10.1038/s42255-024-01045-4 |
0.448 |
|
| 2024 |
Lee SH, Suh JH, Heo MJ, Choi JM, Yang Y, Jung HJ, Gao Z, Yongmei Y, Jung SY, Kolonin MG, Cox AR, Hartig SM, Eltzschig HK, Ju C, Moore DD, et al. The hepatokine orosomucoid 2 mediates beneficial metabolic effects of bile acids. Diabetes. PMID 38320268 DOI: 10.2337/db23-0520 |
0.649 |
|
| 2023 |
Masschelin PM, Saha P, Ochsner SA, Cox AR, Kim KH, Felix JB, Sharp R, Li X, Tan L, Park JH, Wang L, Putluri V, Lorenzi PL, Nuotio-Antar AM, Sun Z, ... ... Moore DD, et al. Vitamin B2 enables regulation of fasting glucose availability. Elife. 12. PMID 37417957 DOI: 10.7554/eLife.84077 |
0.662 |
|
| 2023 |
Heo MJ, Suh JH, Lee SH, Poulsen KL, An YA, Moorthy B, Hartig SM, Moore DD, Kim KH. Aryl Hydrocarbon Receptor Maintains Hepatic Mitochondrial Homeostasis in Mice. Molecular Metabolism. 101717. PMID 37004989 DOI: 10.1016/j.molmet.2023.101717 |
0.653 |
|
| 2022 |
Shen T, Dong B, Meng Y, Moore DD, Yang F. A COP1-GATA2 axis suppresses AR signaling and prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 119: e2205350119. PMID 36251994 DOI: 10.1073/pnas.2205350119 |
0.695 |
|
| 2022 |
Cox AR, Masschelin PM, Saha PK, Felix JB, Sharp R, Lian Z, Xia Y, Chernis N, Bader DA, Kim KH, Li X, Yoshino J, Li X, Li G, Sun Z, ... ... Moore DD, et al. The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice. Cell Metabolism. PMID 36243005 DOI: 10.1016/j.cmet.2022.09.019 |
0.592 |
|
| 2022 |
Suh JH, Kim KH, Conner ME, Moore DD, Preidis GA. Hepatic PPARα Is Destabilized by SIRT1 Deacetylase in Undernourished Male Mice. Frontiers in Nutrition. 9: 831879. PMID 35419389 DOI: 10.3389/fnut.2022.831879 |
0.576 |
|
| 2022 |
Mays SG, D'Agostino EH, Flynn AR, Huang X, Wang G, Liu X, Millings EJ, Okafor CD, Patel A, Cato ML, Cornelison JL, Melchers D, Houtman R, Moore DD, Calvert JW, et al. A phospholipid mimetic targeting LRH-1 ameliorates colitis. Cell Chemical Biology. PMID 35316658 DOI: 10.1016/j.chembiol.2022.03.001 |
0.727 |
|
| 2022 |
Wang W, Han D, Cai Q, Shen T, Dong B, Lewis MT, Wang R, Meng Y, Zhou W, Yi P, Creighton CJ, Moore DD, Yang F. MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade. Nature Communications. 13: 245. PMID 35017531 DOI: 10.1038/s41467-021-27921-1 |
0.682 |
|
| 2021 |
Cai Q, Zhou W, Wang W, Dong B, Han D, Shen T, Creighton CJ, Moore DD, Yang F. MAPK6-AKT signaling promotes tumor growth and resistance to mTOR kinase blockade. Science Advances. 7: eabi6439. PMID 34767444 DOI: 10.1126/sciadv.abi6439 |
0.658 |
|
| 2021 |
Chen ML, Huang X, Wang H, Hegner C, Liu Y, Shang J, Eliason A, Diao H, Park H, Frey B, Wang G, Mosure SA, Solt LA, Kojetin DJ, Rodriguez-Palacios A, ... ... Moore DD, et al. CAR directs T cell adaptation to bile acids in the small intestine. Nature. PMID 33828301 DOI: 10.1038/s41586-021-03421-6 |
0.72 |
|
| 2021 |
Cox AR, Chernis N, Kim KH, Masschelin PM, Saha PK, Briley SM, Sharp R, Li X, Felix JB, Sun Z, Moore DD, Pangas SA, Hartig SM. Ube2i deletion in adipocytes causes lipoatrophy in mice. Molecular Metabolism. 101221. PMID 33771728 DOI: 10.1016/j.molmet.2021.101221 |
0.61 |
|
| 2021 |
Shen T, Wang W, Zhou W, Coleman I, Cai Q, Dong B, Ittmann MM, Creighton CJ, Bian Y, Meng Y, Rowley DR, Nelson PS, Moore DD, Yang F. MAPK4 promotes prostate cancer by concerted activation of androgen receptor and AKT. The Journal of Clinical Investigation. 131. PMID 33586682 DOI: 10.1172/JCI135465 |
0.697 |
|
| 2021 |
Ding L, Zhang E, Yang Q, Jin L, Sousa KM, Dong B, Wang Y, Tu J, Ma X, Tian J, Zhang H, Fang Z, Guan A, Zhang Y, Wang Z, ... Moore DD, et al. Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33526687 DOI: 10.1073/pnas.2019388118 |
0.736 |
|
| 2020 |
Preidis GA, Soni KG, Suh JH, Halder T, Kim KH, Choi JM, Li F, Devaraj S, Conner ME, Coarfa C, Jung SY, Moore DD. Coagulopathy in Malnourished Mice Is Sexually Dimorphic and Regulated by Nutrient-Sensing Nuclear Receptors. Hepatology Communications. 4: 1835-1850. PMID 33305154 DOI: 10.1002/hep4.1622 |
0.769 |
|
| 2020 |
Lee SH, Choi JM, Jung SY, Cox AR, Hartig SM, Moore DD, Kim KH. The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation. Biochemical and Biophysical Research Communications. PMID 33168190 DOI: 10.1016/j.bbrc.2020.10.086 |
0.637 |
|
| 2020 |
Himes RW, Mojarrad M, Eslahi A, Finegold MJ, Maroofian R, Moore DD. NR1H4-related Progressive Familial Intrahepatic Cholestasis 5: Further Evidence for Rapidly Progressive Liver Failure. Journal of Pediatric Gastroenterology and Nutrition. 70: e111-e113. PMID 32443034 DOI: 10.1097/Mpg.0000000000002670 |
0.354 |
|
| 2020 |
Pastore N, Huynh T, Herz NJ, Calcagni' A, Klisch TJ, Brunetti L, Kim KH, De Giorgi M, Hurley A, Carissimo A, Mutarelli M, Aleksieva N, D'Orsi L, Lagor WR, Moore DD, et al. TFEB regulates murine liver cell fate during development and regeneration. Nature Communications. 11: 2461. PMID 32424153 DOI: 10.1038/S41467-020-16300-X |
0.38 |
|
| 2020 |
Ko MS, Yun JY, Baek IJ, Jang JE, Hwang JJ, Lee SE, Heo SH, Bader DA, Lee CH, Han J, Moon JS, Lee JM, Hong EG, Lee IK, Kim SW, ... ... Moore DD, et al. Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice. Autophagy. 1-17. PMID 32400277 DOI: 10.1080/15548627.2020.1753002 |
0.405 |
|
| 2020 |
Treviño LS, Dong J, Kaushal A, Katz TA, Jangid RK, Robertson MJ, Grimm SL, Ambati CSR, Putluri V, Cox AR, Kim KH, May TD, Gallo MR, Moore DD, Hartig SM, et al. Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood. Nature Communications. 11: 2316. PMID 32385268 DOI: 10.1038/S41467-020-15847-Z |
0.513 |
|
| 2020 |
Li X, Yang L, Mao Z, Pan X, Zhao Y, Gu X, Eckel-Mahan K, Zuo Z, Tong Q, Hartig SM, Cheng X, Du G, Moore DD, Bellen HJ, Sesaki H, et al. Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32294302 DOI: 10.1096/Fj.201903100Rr |
0.324 |
|
| 2020 |
Panzitt K, Jungwirth E, Krones E, Lee JM, Pollheimer M, Thallinger GG, Kolb-Lenz D, Xiao R, Thorell A, Trauner M, Fickert P, Marschall HU, Moore DD, Wagner M. FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis. Journal of Hepatology. PMID 32001325 DOI: 10.1016/J.Jhep.2020.01.014 |
0.433 |
|
| 2020 |
Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, Nuotio-Antar AM. Metabolic dysregulation in the Wilson's disease mouse model. Proceedings of the National Academy of Sciences of the United States of America. PMID 31924743 DOI: 10.1073/Pnas.1914267117 |
0.794 |
|
| 2019 |
Dong B, Zhou Y, Wang W, Scott J, Kim KH, Sun Z, Guo Q, Lu Y, Gonzales NM, Wu H, Hartig S, York RB, Yang F, Moore DD. Vitamin D receptor activation in liver macrophages ameliorates hepatic inflammation, steatosis, and insulin resistance in mice. Hepatology (Baltimore, Md.). PMID 31506976 DOI: 10.1002/Hep.30937 |
0.755 |
|
| 2019 |
Mays S, Flynn AR, Cornelison J, Okafor CD, Wang H, Wang G, Huang X, Donaldson H, Millings E, Polavarapu R, Moore D, Calvert J, Jui NT, Ortlund EA. Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design. Journal of Medicinal Chemistry. PMID 31419141 DOI: 10.1021/Acs.Jmedchem.9B00753 |
0.761 |
|
| 2019 |
Zhou Y, Dong B, Kim KH, Choi S, Sun Z, Wu N, Wu Y, Scott J, Moore DD. Vitamin D receptor activation in liver macrophages protects against hepatic endoplasmic reticulum stress in mice. Hepatology (Baltimore, Md.). PMID 31381163 DOI: 10.1002/Hep.30887 |
0.763 |
|
| 2019 |
Choi S, Dong B, Lin CJ, Heo MJ, Kim KH, Sun Z, Wagner M, Suh JM, Wang MC, Moore DD. Methyl-sensing nuclear receptor Liver Receptor Homolog-1 regulates mitochondrial function in mouse hepatocytes. Hepatology (Baltimore, Md.). PMID 31355949 DOI: 10.1002/Hep.30884 |
0.771 |
|
| 2019 |
Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, Shi Q, Zhou H, Zhang Y, Moore DD, Yang F. MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling. The Journal of Clinical Investigation. PMID 30688659 DOI: 10.1172/Jci97712 |
0.703 |
|
| 2019 |
Kim KH, Choi JM, Li F, Dong B, Wooton-Kee CR, Arizpe A, Anakk S, Jung SY, Hartig SM, Moore DD. Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis. Hepatology Communications. 3: 147-159. PMID 30620001 DOI: 10.1002/hep4.1274 |
0.809 |
|
| 2019 |
Wooton-Kee R, Nuotio-Antar A, Moore D. SAT-407-The Wilson’s disease mouse (Atp7b-/-) has profound alterations in the hepatic metabolome and improved insulin sensitivity Journal of Hepatology. 70: e813. DOI: 10.1016/S0618-8278(19)31626-3 |
0.323 |
|
| 2019 |
Wang H, Chen ML, Sundrud M, Moore DD. Mo1873 – The Constitutive Androstane Receptor (CAR) Acts in T Cells to Prevent Bile Acid Driven-Ileitis in Inflammatory Bowel Disease (IBD) Gastroenterology. 156: S-871. DOI: 10.1016/S0016-5085(19)39140-1 |
0.315 |
|
| 2018 |
Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KD. Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. Gastroenterology. PMID 30170115 DOI: 10.1053/J.Gastro.2018.08.037 |
0.807 |
|
| 2018 |
Eblimit Z, Thevananther S, Karpen SJ, Taegtmeyer H, Moore DD, Adorini L, Penny DJ, Desai MS. TGR5 activation induces cytoprotective changes in the heart and improves myocardial adaptability to physiologic, inotropic and pressure induced stress in mice. Cardiovascular Therapeutics. e12462. PMID 30070769 DOI: 10.1111/1755-5922.12462 |
0.349 |
|
| 2018 |
Koh EH, Chernis N, Saha PK, Xiao L, Bader DA, Zhu B, Rajapakshe K, Hamilton MP, Liu X, Perera D, Chen X, York B, Trauner M, Coarfa C, Bajaj M, ... Moore DD, et al. miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity. Diabetes. PMID 30002134 DOI: 10.2337/Db17-1378 |
0.338 |
|
| 2018 |
Kim KH, Choi JM, Li F, Arizpe A, Wooton-Kee CR, Anakk S, Jung SY, Finegold MJ, Moore DD. Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis. Endocrinology. PMID 29718219 DOI: 10.1210/En.2018-00110 |
0.809 |
|
| 2018 |
Bissig K, Moore D, Marini J, Elsea S, Bissig B, Legras X, Pankowicz F, Kim K, Martins C, Barzi M, Wooton-Kee R, Lagor W. Rapid generation of somatic liver knockouts using multiplex CRISPR/Cas9 editing Journal of Hepatology. 68: S128. DOI: 10.1016/S0168-8278(18)30467-7 |
0.38 |
|
| 2017 |
Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, Saha PK, Lee ME, Phillips KJ, Jain M, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, ... ... Moore DD, et al. Asprosin is a centrally acting orexigenic hormone. Nature Medicine. PMID 29106398 DOI: 10.1038/Nm.4432 |
0.351 |
|
| 2017 |
Wang W, Meng Y, Dong B, Dong J, Ittmann MM, Creighton CJ, Yang L, Zhang H, Shen T, Wang J, Rowley DR, Li Y, Chen F, Moore DD, Yang F. A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis. Neoplasia (New York, N.Y.). 19: 421-428. PMID 28433771 DOI: 10.1016/J.Neo.2017.03.003 |
0.705 |
|
| 2017 |
Kim KH, Choi S, Zhou Y, Kim EY, Lee JM, Saha PK, Anakk S, Moore DD. Hepatic FXR/SHP Axis Modulates Systemic Glucose and Fatty Acid Homeostasis in Aged Mice. Hepatology (Baltimore, Md.). PMID 28378930 DOI: 10.1002/Hep.29199 |
0.628 |
|
| 2017 |
Kumar R, Mota LC, Litoff EJ, Rooney JP, Boswell WT, Courter E, Henderson CM, Hernandez JP, Corton JC, Moore DD, Baldwin WS. Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice. Plos One. 12: e0174355. PMID 28350814 DOI: 10.1371/Journal.Pone.0174355 |
0.43 |
|
| 2017 |
Preidis GA, Kim KH, Moore DD. Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance. The Journal of Clinical Investigation. PMID 28287408 DOI: 10.1172/Jci88893 |
0.782 |
|
| 2017 |
Kim KH, Moore DD. Regulation of Liver Energy Balance by the Nuclear Receptors Farnesoid X Receptor and Peroxisome Proliferator Activated Receptor α. Digestive Diseases (Basel, Switzerland). 35: 203-209. PMID 28249296 DOI: 10.1159/000450912 |
0.574 |
|
| 2017 |
Wang H, Lee JM, Zhou Y, Moore DD. Targeting the Nuclear Receptor LRH-1 to Treat Inflammatory Bowel Disease in Mice Gastroenterology. 152: S90. DOI: 10.1016/S0016-5085(17)30651-0 |
0.363 |
|
| 2016 |
Kettner NM, Voicu H, Finegold MJ, Coarfa C, Sreekumar A, Putluri N, Katchy CA, Lee C, Moore DD, Fu L. Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis. Cancer Cell. PMID 27889186 DOI: 10.1016/J.Ccell.2016.10.007 |
0.461 |
|
| 2016 |
Desai M, Mathur B, Eblimit Z, Vasquez H, Taegtmeyer H, Karpen S, Penny DJ, Moore DD, Anakk S. Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart. Hepatology (Baltimore, Md.). PMID 27774647 DOI: 10.1002/Hep.28890 |
0.337 |
|
| 2016 |
Wu N, Ho Kim K, Zhou Y, Man Lee J, Kettner NM, Mamrosh JL, Choi S, Fu L, Moore DD. Small Heterodimer Partner (NR0B2) Coordinates Nutrient Signaling and the Circadian Clock in Mice. Molecular Endocrinology (Baltimore, Md.). me20151295. PMID 27427832 DOI: 10.1210/Me.2015-1295 |
0.457 |
|
| 2016 |
Ho Kim K, Lee JM, Zhou Y, Harpavat S, Moore DD. Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells. Molecular Endocrinology (Baltimore, Md.). me20161029. PMID 27355192 DOI: 10.1210/Me.2016-1029 |
0.417 |
|
| 2016 |
Ding L, Sousa KM, Jin L, Dong B, Kim BW, Ramirez R, Xiao Z, Gu Y, Yang Q, Wang J, Yu D, Pigazzi A, Schones D, Yang L, Moore D, et al. Vertical Sleeve Gastrectomy Activates GPBAR-1/TGR5 to Sustain Weight Loss, Improve Fatty Liver, and Remit Insulin Resistance in Mice. Hepatology (Baltimore, Md.). PMID 27312543 DOI: 10.1002/Hep.28689 |
0.755 |
|
| 2016 |
Gomez-Ospina N, Potter CJ, Xiao R, Manickam K, Kim MS, Kim KH, Shneider BL, Picarsic JL, Jacobson TA, Zhang J, He W, Liu P, Knisely AS, Finegold MJ, Muzny DM, ... ... Moore DD, et al. Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. Nature Communications. 7: 10713. PMID 26888176 DOI: 10.1038/Ncomms10713 |
0.587 |
|
| 2015 |
Ahn HY, Kim HH, Kim YA, Kim M, Ohn JH, Chung SS, Lee YK, Park DJ, Park KS, Moore DD, Park YJ. Thyroid Hormone Regulates the mRNA Expression of Small Heterodimer Partner through Liver Receptor Homolog-1. Endocrinology and Metabolism (Seoul, Korea). PMID 26485468 DOI: 10.3803/Enm.2015.30.4.584 |
0.426 |
|
| 2015 |
Rich AJ, Lachowsky NJ, Cui Z, Sereda P, Lal A, Birch R, Montaner J, Moore D, Hogg RS, Roth EA. Substance use, sexual behaviour and prevention strategies of Vancouver gay and bisexual men who recently attended group sex events. Culture, Health & Sexuality. 1-16. PMID 26443295 DOI: 10.1080/13691058.2015.1084649 |
0.306 |
|
| 2015 |
Carter A, Lachowsky N, Rich A, Forrest JI, Sereda P, Cui Z, Roth E, Kaida A, Moore D, Montaner JS, Hogg RS. Gay and bisexual men's awareness and knowledge of treatment as prevention: findings from the Momentum Health Study in Vancouver, Canada. Journal of the International Aids Society. 18: 20039. PMID 26268817 DOI: 10.7448/Ias.18.1.20039 |
0.303 |
|
| 2015 |
Wagner M, Choi S, Panzitt K, Mamrosh JL, Man Lee J, Zaufel A, Xiao R, Wooton-Kee R, Ståhlman M, Newgard CB, Borén J, Moore DD. LRH-1 is a critical determinant of methyl-pool metabolism. Hepatology (Baltimore, Md.). PMID 26267291 DOI: 10.1002/Hep.28124 |
0.416 |
|
| 2015 |
Wooton-Kee CR, Jain AK, Wagner M, Grusak MA, Finegold MJ, Lutsenko S, Moore DD. Elevated copper impairs hepatic nuclear receptor function in Wilson's disease. The Journal of Clinical Investigation. PMID 26241054 DOI: 10.1172/Jci78991 |
0.803 |
|
| 2015 |
Yuk JM, Kim TS, Kim SY, Lee HM, Han J, Dufour CR, Kim JK, Jin HS, Yang CS, Park KS, Lee CH, Kim JM, Kweon GR, Choi HS, Vanacker JM, ... Moore DD, et al. Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation. Immunity. 43: 80-91. PMID 26200012 DOI: 10.1016/J.Immuni.2015.07.003 |
0.395 |
|
| 2015 |
Hartig SM, Bader DA, Abadie KV, Motamed M, Hamilton MP, Long W, York B, Mueller M, Wagner M, Trauner M, Chan L, Bajaj M, Moore DD, Mancini MA, McGuire SE. Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes. Molecular Endocrinology (Baltimore, Md.). 29: 1320-33. PMID 26192107 DOI: 10.1210/Me.2015-1084 |
0.35 |
|
| 2015 |
Kettner NM, Mayo SA, Hua J, Lee C, Moore DD, Fu L. Circadian Dysfunction Induces Leptin Resistance in Mice. Cell Metabolism. PMID 26166747 DOI: 10.1016/J.Cmet.2015.06.005 |
0.342 |
|
| 2015 |
Fu X, Dong B, Tian Y, Lefebvre P, Meng Z, Wang X, Pattou F, Han W, Wang X, Lou F, Jove R, Staels B, Moore DD, Huang W. MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids. The Journal of Clinical Investigation. 125: 2497-509. PMID 25961460 DOI: 10.1172/Jci75438 |
0.709 |
|
| 2015 |
Tseng HT, Park YJ, Lee YK, Moore DD. The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice. Journal of Biomedical Science. 22: 30. PMID 25951943 DOI: 10.1186/S12929-015-0133-3 |
0.468 |
|
| 2015 |
Dong B, Lee JS, Park YY, Yang F, Xu G, Huang W, Finegold MJ, Moore DD. Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis. Nature Communications. 6: 5944. PMID 25661872 DOI: 10.1038/Ncomms6944 |
0.734 |
|
| 2015 |
Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC. Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. Science (New York, N.Y.). 347: 83-6. PMID 25554789 DOI: 10.1126/Science.1258857 |
0.352 |
|
| 2015 |
Desai MS, Eblimit Z, Thevananther S, Kosters A, Moore DD, Penny DJ, Karpen SJ. Cardiomyopathy reverses with recovery of liver injury, cholestasis and cholanemia in mouse model of biliary fibrosis. Liver International : Official Journal of the International Association For the Study of the Liver. 35: 1464-77. PMID 24330504 DOI: 10.1111/Liv.12438 |
0.372 |
|
| 2015 |
Wang W, Ren J, Dong B, Ittmann MM, Moore DD, Yang F. Abstract 2280: A novel c-Myc transgenic model for human cancers Cancer Research. 75: 2280-2280. DOI: 10.1158/1538-7445.Am2015-2280 |
0.708 |
|
| 2014 |
Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, Moore DD. Nutrient-sensing nuclear receptors coordinate autophagy. Nature. 516: 112-5. PMID 25383539 DOI: 10.1038/Nature13961 |
0.618 |
|
| 2014 |
Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS. Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol. Gastroenterology. 146: 1048-59. PMID 24365583 DOI: 10.1053/J.Gastro.2013.12.027 |
0.434 |
|
| 2014 |
Shah P, Guo T, Moore DD, Ghose R. Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 172-81. PMID 24194512 DOI: 10.1124/Dmd.113.053850 |
0.41 |
|
| 2014 |
Jung D, York JP, Wang L, Yang C, Zhang A, Francis HL, Webb P, McKeehan WL, Alpini G, Lesage GD, Moore DD, Xia X. FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway. Pflã¼Gers Archiv : European Journal of Physiology. 466: 1011-9. PMID 24068255 DOI: 10.1007/S00424-013-1364-3 |
0.414 |
|
| 2014 |
Kim SC, Kim CK, Axe D, Cook A, Lee M, Li T, Smallwood N, Chiang JY, Hardwick JP, Moore DD, Lee YK. All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade. Hepatology (Baltimore, Md.). 59: 1750-60. PMID 24038081 DOI: 10.1002/Hep.26699 |
0.467 |
|
| 2014 |
Kerr TA, Matsumoto Y, Matsumoto H, Xie Y, Hirschberger LL, Stipanuk MH, Anakk S, Moore DD, Watanabe M, Kennedy S, Davidson NO. Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolism. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 44: E218-28. PMID 24033844 DOI: 10.1111/Hepr.12230 |
0.449 |
|
| 2014 |
Burrin D, Stoll B, Moore D. Digestive physiology of the pig symposium: intestinal bile acid sensing is linked to key endocrine and metabolic signaling pathways. Journal of Animal Science. 91: 1991-2000. PMID 23729782 DOI: 10.2527/Jas.2013-6331 |
0.413 |
|
| 2014 |
Kettner NM, Moore DD, Fu L. Abstract A32: Studying circadian disruption as a novel risk factor of hepatocellular carcinoma using mouse models Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Modorg-A32 |
0.383 |
|
| 2014 |
Wagner M, Mamrosh J, Wooton-Kee R, Lee J, Xiao R, Putluri N, Stahlman M, Boren J, Sreekumar A, Moore D. P275 THE NUCLEAR RECEPTOR LRH-1 IS A KEY REGULATOR OF THE HEPATIC METHYL-POOL AND PHOSPHATIDYLCHOLINE METABOLISM Journal of Hepatology. 60: S157. DOI: 10.1016/S0168-8278(14)60437-2 |
0.379 |
|
| 2013 |
Anakk S, Bhosale M, Schmidt VA, Johnson RL, Finegold MJ, Moore DD. Bile acids activate YAP to promote liver carcinogenesis. Cell Reports. 5: 1060-9. PMID 24268772 DOI: 10.1016/J.Celrep.2013.10.030 |
0.477 |
|
| 2013 |
Moore DD. Physiology: A metabolic minuet. Nature. 502: 454-5. PMID 24153294 DOI: 10.1038/502454A |
0.428 |
|
| 2013 |
Lee J, Moulik M, Fang Z, Saha P, Zou F, Xu Y, Nelson DL, Ma K, Moore DD, Yechoor VK. Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Molecular and Cellular Biology. 33: 2327-38. PMID 23547261 DOI: 10.1128/Mcb.01421-12 |
0.345 |
|
| 2013 |
Jiang Y, Iakova P, Jin J, Sullivan E, Sharin V, Hong IH, Anakk S, Mayor A, Darlington G, Finegold M, Moore D, Timchenko NA. Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology (Baltimore, Md.). 57: 1098-106. PMID 23172628 DOI: 10.1002/Hep.26146 |
0.44 |
|
| 2012 |
Xia X, Jung D, Webb P, Zhang A, Zhang B, Li L, Ayers SD, Gabbi C, Ueno Y, Gustafsson JÅ, Alpini G, Moore DD, Lesage GD. Liver X receptor β and peroxisome proliferator-activated receptor δ regulate cholesterol transport in murine cholangiocytes. Hepatology (Baltimore, Md.). 56: 2288-96. PMID 22729460 DOI: 10.1002/Hep.25919 |
0.428 |
|
| 2012 |
Park YJ, Lee EK, Lee YK, Park do J, Jang HC, Moore DD. Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice. Toxicology and Applied Pharmacology. 263: 131-7. PMID 22503787 DOI: 10.1016/J.Taap.2012.03.017 |
0.417 |
|
| 2012 |
Chen WD, Fu X, Dong B, Wang YD, Shiah S, Moore DD, Huang W. Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver. Hepatology (Baltimore, Md.). 56: 1499-509. PMID 22488010 DOI: 10.1002/Hep.25766 |
0.746 |
|
| 2012 |
Xiao R, Sun D, Ayers S, Xi Y, Li W, Baxter JD, Moore DD. Research resource: The estrogen receptor α cistrome defined by damIP Molecular Endocrinology. 26: 349-357. PMID 22207717 DOI: 10.1210/Me.2011-1080 |
0.314 |
|
| 2012 |
Reese VC, Moore DD, McLachlan A. Limited effects of bile acids and small heterodimer partner on hepatitis B virus biosynthesis in vivo. Journal of Virology. 86: 2760-8. PMID 22171277 DOI: 10.1128/Jvi.06742-11 |
0.443 |
|
| 2012 |
Jain AK, Stoll B, Burrin DG, Holst JJ, Moore DD. Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G218-24. PMID 22094603 DOI: 10.1152/Ajpgi.00280.2011 |
0.378 |
|
| 2012 |
Kerr TA, Matsumoto Y, Matsumoto H, Xie Y, Anakk S, Kennedy S, Moore DD, Davidson NO. 829 Cysteine Sulfinic Acid Decarboxylase Regulation by Bile Acids: A Role for FXR and SHP in Hepatic Taurine Metabolism Gastroenterology. 142: S-930. DOI: 10.1016/S0016-5085(12)63606-3 |
0.363 |
|
| 2011 |
Lee J, Kim MS, Li R, Liu VY, Fu L, Moore DD, Ma K, Yechoor VK. Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells. Islets. 3: 381-8. PMID 22045262 DOI: 10.4161/Isl.3.6.18157 |
0.338 |
|
| 2011 |
Park YJ, Kim SC, Kim J, Anakk S, Lee JM, Tseng HT, Yechoor V, Park J, Choi JS, Jang HC, Lee KU, Novak CM, Moore DD, Lee YK. Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. Journal of Lipid Research. 52: 2234-44. PMID 21949050 DOI: 10.1194/Jlr.M016048 |
0.442 |
|
| 2011 |
Sberna AL, Assem M, Xiao R, Ayers S, Gautier T, Guiu B, Deckert V, Chevriaux A, Grober J, Le Guern N, Pais de Barros JP, Moore DD, Lagrost L, Masson D. Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 2232-9. PMID 21778422 DOI: 10.1161/Atvbaha.110.222497 |
0.392 |
|
| 2011 |
Yuk JM, Shin DM, Lee HM, Kim JJ, Kim SW, Jin HS, Yang CS, Park KA, Chanda D, Kim DK, Huang SM, Lee SK, Lee CH, Kim JM, Song CH, ... ... Moore DD, et al. The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nature Immunology. 12: 742-51. PMID 21725320 DOI: 10.1038/Ni.2064 |
0.389 |
|
| 2011 |
Smetanina MA, Pakharukova MY, Kurinna SM, Dong B, Hernandez JP, Moore DD, Merkulova TI. Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes. Toxicology and Applied Pharmacology. 255: 76-85. PMID 21672546 DOI: 10.1016/J.Taap.2011.05.019 |
0.762 |
|
| 2011 |
Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, Pathak MC, Ortlund EA, Moore DD. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature. 474: 506-10. PMID 21614002 DOI: 10.1038/Nature10111 |
0.348 |
|
| 2011 |
Dwivedi SK, Singh N, Kumari R, Mishra JS, Tripathi S, Banerjee P, Shah P, Kukshal V, Tyagi AM, Gaikwad AN, Chaturvedi RK, Mishra DP, Trivedi AK, Sanyal S, Chattopadhyay N, ... ... Moore DD, et al. Bile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor α. Molecular Endocrinology (Baltimore, Md.). 25: 922-32. PMID 21493670 DOI: 10.1210/Me.2010-0512 |
0.401 |
|
| 2011 |
Moore DD. Physiology. Crise de foie, redux? Science (New York, N.Y.). 331: 1275-6. PMID 21393533 DOI: 10.1126/Science.1203194 |
0.412 |
|
| 2011 |
Chopra AR, Kommagani R, Saha P, Louet JF, Salazar C, Song J, Jeong J, Finegold M, Viollet B, DeMayo F, Chan L, Moore DD, O'Malley BW. Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metabolism. 13: 35-43. PMID 21195347 DOI: 10.1016/J.Cmet.2010.12.001 |
0.334 |
|
| 2011 |
Anakk S, Watanabe M, Ochsner SA, McKenna NJ, Finegold MJ, Moore DD. Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. The Journal of Clinical Investigation. 121: 86-95. PMID 21123943 DOI: 10.1172/Jci42846 |
0.363 |
|
| 2011 |
Moore DD. Commentary: The Year in Orphan Nuclear Receptors and Their Coregulators Molecular Endocrinology. 25: 1983-1988. DOI: 10.1210/Me.2011-1228 |
0.307 |
|
| 2010 |
Gupte AA, Liu JZ, Ren Y, Minze LJ, Wiles JR, Collins AR, Lyon CJ, Pratico D, Finegold MJ, Wong ST, Webb P, Baxter JD, Moore DD, Hsueh WA. Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology (Baltimore, Md.). 52: 2001-11. PMID 20938947 DOI: 10.1002/Hep.23941 |
0.457 |
|
| 2010 |
Lee S, Donehower LA, Herron AJ, Moore DD, Fu L. Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. Plos One. 5: e10995. PMID 20539819 DOI: 10.1371/Journal.Pone.0010995 |
0.346 |
|
| 2009 |
Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD. Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 18831-6. PMID 19850873 DOI: 10.1073/Pnas.0909731106 |
0.743 |
|
| 2009 |
Margolis RN, Moore DD, Willson TM, Guy RK. Chemical approaches to nuclear receptors in metabolism. Science Signaling. 2: mr5. PMID 19654413 DOI: 10.1126/Scisignal.282Mr5 |
0.36 |
|
| 2009 |
Del Bas JM, Ricketts ML, Vaqué M, Sala E, Quesada H, Ardevol A, Salvadó MJ, Blay M, Arola L, Moore DD, Pujadas G, Fernandez-Larrea J, Bladé C. Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner. Molecular Nutrition & Food Research. 53: 805-14. PMID 19496086 DOI: 10.1002/mnfr.200800364 |
0.379 |
|
| 2009 |
Dong B, Qatanani M, Moore DD. Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes. Hepatology (Baltimore, Md.). 50: 622-9. PMID 19489075 DOI: 10.1002/Hep.23025 |
0.728 |
|
| 2009 |
Li T, Ma H, Park YJ, Lee YK, Strom S, Moore DD, Chiang JY. Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice. Biochimica Et Biophysica Acta. 1791: 991-6. PMID 19463968 DOI: 10.1016/J.Bbalip.2009.05.004 |
0.419 |
|
| 2009 |
McKenna NJ, Cooney AJ, DeMayo FJ, Downes M, Glass CK, Lanz RB, Lazar MA, Mangelsdorf DJ, Moore DD, Qin J, Steffen DL, Tsai MJ, Tsai SY, Yu R, Margolis RN, et al. Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Molecular Endocrinology (Baltimore, Md.). 23: 740-6. PMID 19423650 DOI: 10.1210/Me.2009-0135 |
0.322 |
|
| 2009 |
Li Y, Ross-Viola JS, Shay NF, Moore DD, Ricketts ML. Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner. The Journal of Nutrition. 139: 898-904. PMID 19297428 DOI: 10.3945/Jn.108.103572 |
0.418 |
|
| 2009 |
Zhang L, Huang X, Meng Z, Dong B, Shiah S, Moore DD, Huang W. Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration. Molecular Endocrinology (Baltimore, Md.). 23: 137-45. PMID 19056864 DOI: 10.1210/Me.2008-0198 |
0.755 |
|
| 2009 |
Hernandez JP, Mota LC, Huang W, Moore DD, Baldwin WS. Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR) Toxicology. 256: 53-64. PMID 19041682 DOI: 10.1016/J.Tox.2008.11.002 |
0.324 |
|
| 2008 |
Chopra AR, Louet JF, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science (New York, N.Y.). 322: 1395-9. PMID 19039140 DOI: 10.1126/Science.1164847 |
0.381 |
|
| 2008 |
Wang YD, Chen WD, Moore DD, Huang W. FXR: a metabolic regulator and cell protector. Cell Research. 18: 1087-95. PMID 18825165 DOI: 10.1038/Cr.2008.289 |
0.397 |
|
| 2008 |
Blanco-Bose WE, Murphy MJ, Ehninger A, Offner S, Dubey C, Huang W, Moore DD, Trumpp A. C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia. Hepatology (Baltimore, Md.). 48: 1302-11. PMID 18798339 DOI: 10.1002/Hep.22475 |
0.387 |
|
| 2008 |
Kleiner HE, Xia X, Sonoda J, Zhang J, Pontius E, Abey J, Evans RM, Moore DD, DiGiovanni J. Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice. Toxicology and Applied Pharmacology. 232: 337-50. PMID 18692084 DOI: 10.1016/J.Taap.2008.07.004 |
0.438 |
|
| 2008 |
Zhang Y, Xu P, Park K, Choi Y, Moore DD, Wang L. Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology (Baltimore, Md.). 48: 289-98. PMID 18537191 DOI: 10.1002/Hep.22342 |
0.424 |
|
| 2008 |
Lee YK, Moore DD. Liver receptor homolog-1, an emerging metabolic modulator. Frontiers in Bioscience : a Journal and Virtual Library. 13: 5950-8. PMID 18508634 DOI: 10.2741/3128 |
0.47 |
|
| 2008 |
Merrell MD, Jackson JP, Augustine LM, Fisher CD, Slitt AL, Maher JM, Huang W, Moore DD, Zhang Y, Klaassen CD, Cherrington NJ. The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1716-21. PMID 18474683 DOI: 10.1124/Dmd.108.020867 |
0.469 |
|
| 2008 |
Masson D, Qatanani M, Sberna AL, Xiao R, Pais de Barros JP, Grober J, Deckert V, Athias A, Gambert P, Lagrost L, Moore DD, Assem M. Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice. Journal of Lipid Research. 49: 1682-91. PMID 18441373 DOI: 10.1194/Jlr.M700374-Jlr200 |
0.429 |
|
| 2008 |
Park YJ, Qatanani M, Chua SS, LaRey JL, Johnson SA, Watanabe M, Moore DD, Lee YK. Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis. Hepatology (Baltimore, Md.). 47: 1578-86. PMID 18393320 DOI: 10.1002/hep.22196 |
0.381 |
|
| 2008 |
Roth A, Looser R, Kaufmann M, Blättler SM, Rencurel F, Huang W, Moore DD, Meyer UA. Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression. Molecular Pharmacology. 73: 1282-9. PMID 18187584 DOI: 10.1124/Mol.107.041012 |
0.457 |
|
| 2008 |
Jain AK, Ma K, Moore DD. W1870 Replacement of Zinc By Copper in Nuclear Receptors May Contribute to the Pathogenesis of Wilson's Disease Gastroenterology. 134: A-842. DOI: 10.1016/S0016-5085(08)63937-2 |
0.302 |
|
| 2007 |
Carter BA, Taylor OA, Prendergast DR, Zimmerman TL, Von Furstenberg R, Moore DD, Karpen SJ. Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. Pediatric Research. 62: 301-6. PMID 17622954 DOI: 10.1203/Pdr.0B013E3181256492 |
0.408 |
|
| 2007 |
Huang J, Iqbal J, Saha PK, Liu J, Chan L, Hussain MM, Moore DD, Wang L. Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology (Baltimore, Md.). 46: 147-57. PMID 17526026 DOI: 10.1002/Hep.21632 |
0.484 |
|
| 2007 |
Amador-Noguez D, Dean A, Huang W, Setchell K, Moore D, Darlington G. Alterations in xenobiotic metabolism in the long-lived Little mice. Aging Cell. 6: 453-70. PMID 17521389 DOI: 10.1111/J.1474-9726.2007.00300.X |
0.463 |
|
| 2007 |
Hernandez JP, Huang W, Chapman LM, Chua S, Moore DD, Baldwin WS. The environmental estrogen, nonylphenol, activates the constitutive androstane receptor. Toxicological Sciences : An Official Journal of the Society of Toxicology. 98: 416-26. PMID 17483497 DOI: 10.1093/Toxsci/Kfm107 |
0.307 |
|
| 2007 |
Ricketts ML, Boekschoten MV, Kreeft AJ, Hooiveld GJ, Moen CJ, Müller M, Frants RR, Kasanmoentalib S, Post SM, Princen HM, Porter JG, Katan MB, Hofker MH, Moore DD. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Molecular Endocrinology (Baltimore, Md.). 21: 1603-16. PMID 17456796 DOI: 10.1210/Me.2007-0133 |
0.38 |
|
| 2007 |
Yang F, Huang X, Yi T, Yen Y, Moore DD, Huang W. Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Research. 67: 863-7. PMID 17283114 DOI: 10.1158/0008-5472.Can-06-1078 |
0.48 |
|
| 2007 |
Farhana L, Dawson MI, Leid M, Wang L, Moore DD, Liu G, Xia Z, Fontana JA. Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor. Cancer Research. 67: 318-25. PMID 17210713 DOI: 10.1158/0008-5472.Can-06-2164 |
0.332 |
|
| 2007 |
Anakk S, Huang W, Staudinger JL, Tan K, Cole TJ, Moore DD, Strobel HW. Gender dictates the nuclear receptor-mediated regulation of CYP3A44. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 36-42. PMID 17020958 DOI: 10.1124/Dmd.106.011270 |
0.424 |
|
| 2006 |
Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, Kliewer SA. International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Pharmacological Reviews. 58: 742-59. PMID 17132852 DOI: 10.1124/Pr.58.4.6 |
0.362 |
|
| 2006 |
Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Molecular Endocrinology (Baltimore, Md.). 20: 2671-81. PMID 16803864 DOI: 10.1210/Me.2006-0224 |
0.387 |
|
| 2006 |
Baskin-Bey ES, Huang W, Ishimura N, Isomoto H, Bronk SF, Braley K, Craig RW, Moore DD, Gores GJ. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology (Baltimore, Md.). 44: 252-62. PMID 16799968 DOI: 10.1002/Hep.21236 |
0.446 |
|
| 2006 |
Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, Dong B, Huang X, Moore DD. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science (New York, N.Y.). 312: 233-6. PMID 16614213 DOI: 10.1126/Science.1121435 |
0.75 |
|
| 2006 |
Slitt AL, Cherrington NJ, Dieter MZ, Aleksunes LM, Scheffer GL, Huang W, Moore DD, Klaassen CD. trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors. Molecular Pharmacology. 69: 1554-63. PMID 16449384 DOI: 10.1124/Mol.105.014571 |
0.486 |
|
| 2006 |
Lee YK, Choi YH, Chua S, Park YJ, Moore DD. Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation. The Journal of Biological Chemistry. 281: 7850-5. PMID 16439367 DOI: 10.1074/Jbc.M509115200 |
0.368 |
|
| 2006 |
Datta S, Wang L, Moore DD, Osborne TF. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake. The Journal of Biological Chemistry. 281: 807-12. PMID 16282330 DOI: 10.1074/Jbc.M511050200 |
0.406 |
|
| 2005 |
Columbano A, Ledda-Columbano GM, Pibiri M, Cossu C, Menegazzi M, Moore DD, Huang W, Tian J, Locker J. Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia. Hepatology (Baltimore, Md.). 42: 1118-26. PMID 16231353 DOI: 10.1002/Hep.20883 |
0.442 |
|
| 2005 |
Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, Moore DD. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metabolism. 2: 227-38. PMID 16213225 DOI: 10.1016/J.Cmet.2005.08.010 |
0.334 |
|
| 2005 |
Qatanani M, Moore DD. CAR, the continuously advancing receptor, in drug metabolism and disease. Current Drug Metabolism. 6: 329-39. PMID 16101572 DOI: 10.2174/1389200054633899 |
0.3 |
|
| 2005 |
Ricketts ML, Moore DD, Banz WJ, Mezei O, Shay NF. Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors. A review. The Journal of Nutritional Biochemistry. 16: 321-30. PMID 15936643 DOI: 10.1016/J.Jnutbio.2004.11.008 |
0.374 |
|
| 2005 |
Huang W, Zhang J, Washington M, Liu J, Parant JM, Lozano G, Moore DD. Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Molecular Endocrinology (Baltimore, Md.). 19: 1646-53. PMID 15831521 DOI: 10.1210/Me.2004-0520 |
0.418 |
|
| 2005 |
Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nature Structural & Molecular Biology. 12: 357-63. PMID 15723037 DOI: 10.1038/Nsmb910 |
0.367 |
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| 2005 |
Stedman CA, Liddle C, Coulter SA, Sonoda J, Alvarez JG, Moore DD, Evans RM, Downes M. Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. Proceedings of the National Academy of Sciences of the United States of America. 102: 2063-8. PMID 15684063 DOI: 10.1073/Pnas.0409794102 |
0.476 |
|
| 2005 |
Qatanani M, Zhang J, Moore DD. Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism. Endocrinology. 146: 995-1002. PMID 15564320 DOI: 10.1210/En.2004-1350 |
0.351 |
|
| 2004 |
Zhang J, Huang W, Qatanani M, Evans RM, Moore DD. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. The Journal of Biological Chemistry. 279: 49517-22. PMID 15358766 DOI: 10.1074/Jbc.M409041200 |
0.423 |
|
| 2004 |
Huang W, Zhang J, Wei P, Schrader WT, Moore DD. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Molecular Endocrinology (Baltimore, Md.). 18: 2402-8. PMID 15272053 DOI: 10.1210/Me.2004-0046 |
0.441 |
|
| 2004 |
Qatanani M, Wei P, Moore DD. Alterations in the distribution and orexigenic effects of dexamethasone in CAR-null mice. Pharmacology, Biochemistry, and Behavior. 78: 285-91. PMID 15219769 DOI: 10.1016/J.Pbb.2004.04.001 |
0.437 |
|
| 2004 |
Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans RM, Moore DD, Borst P, Schuetz JD. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. The Journal of Biological Chemistry. 279: 22250-7. PMID 15004017 DOI: 10.1074/Jbc.M314111200 |
0.362 |
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| 2004 |
Anakk S, Kalsotra A, Kikuta Y, Huang W, Zhang J, Staudinger JL, Moore DD, Strobel HW. CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11. The Pharmacogenomics Journal. 4: 91-101. PMID 14770174 DOI: 10.1038/Sj.Tpj.6500222 |
0.419 |
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| 2004 |
Saini SP, Sonoda J, Xu L, Toma D, Uppal H, Mu Y, Ren S, Moore DD, Evans RM, Xie W. A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Molecular Pharmacology. 65: 292-300. PMID 14742670 DOI: 10.1124/Mol.65.2.292 |
0.467 |
|
| 2004 |
Huang W, Zhang J, Moore DD. A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. The Journal of Clinical Investigation. 113: 137-43. PMID 14702117 DOI: 10.1172/Jci18385 |
0.447 |
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| 2003 |
Cherrington NJ, Slitt AL, Maher JM, Zhang XX, Zhang J, Huang W, Wan YJ, Moore DD, Klaassen CD. Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1315-9. PMID 14570762 DOI: 10.1124/Dmd.31.11.1315 |
0.413 |
|
| 2003 |
Wang L, Han Y, Kim CS, Lee YK, Moore DD. Resistance of SHP-null mice to bile acid-induced liver damage. The Journal of Biological Chemistry. 278: 44475-81. PMID 12933814 DOI: 10.1074/Jbc.M305258200 |
0.403 |
|
| 2003 |
Tzameli I, Chua SS, Cheskis B, Moore DD. Complex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CAR. Nuclear Receptor. 1: 2. PMID 12904257 DOI: 10.1186/1478-1336-1-2 |
0.337 |
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| 2003 |
Huang W, Zhang J, Chua SS, Qatanani M, Han Y, Granata R, Moore DD. Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proceedings of the National Academy of Sciences of the United States of America. 100: 4156-61. PMID 12644704 DOI: 10.1073/Pnas.0630614100 |
0.487 |
|
| 2003 |
Urizar NL, Moore DD. GUGULIPID: A Natural Cholesterol-Lowering Agent Annual Review of Nutrition. 23: 303-313. DOI: 10.1146/Annurev.Nutr.23.011702.073102 |
0.355 |
|
| 2003 |
GHOSE R, LI D, ZIMMERMAN T, WANG L, MOORE D, KARPEN S. 108 Roles of JNK and SHP in endotoxin-mediated suppression of NTCP gene expression Hepatology. 38: 209-209. DOI: 10.1016/S0270-9139(03)80151-9 |
0.311 |
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| 2002 |
Moore DD. Does loss of bile acid homeostasis make mice melancholy Journal of Clinical Investigation. 110: 1067-1069. PMID 12393840 DOI: 10.1172/Jci16943 |
0.38 |
|
| 2002 |
Zhang J, Huang W, Chua SS, Wei P, Moore DD. Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science (New York, N.Y.). 298: 422-4. PMID 12376703 DOI: 10.1126/Science.1073502 |
0.437 |
|
| 2002 |
Wang L, Lee YK, Bundman D, Han Y, Thevananther S, Kim CS, Chua SS, Wei P, Heyman RA, Karin M, Moore DD. Redundant pathways for negative feedback regulation of bile acid production. Developmental Cell. 2: 721-31. PMID 12062085 DOI: 10.1016/S1534-5807(02)00187-9 |
0.426 |
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| 2002 |
Wei P, Zhang J, Dowhan DH, Han Y, Moore DD. Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response. The Pharmacogenomics Journal. 2: 117-26. PMID 12049174 DOI: 10.1038/Sj.Tpj.6500087 |
0.44 |
|
| 2002 |
Hwang ST, Urizar NL, Moore DD, Henning SJ. Bile acids regulate the ontogenic expression of ileal bile acid binding protein in the rat via the farnesoid X receptor. Gastroenterology. 122: 1483-92. PMID 11984532 DOI: 10.1053/Gast.2002.32982 |
0.377 |
|
| 2002 |
Seo YW, Sanyal S, Kim HJ, Won DH, An JY, Amano T, Zavacki AM, Kwon HB, Shi YB, Kim WS, Kang H, Moore DD, Choi HS. FOR, a novel orphan nuclear receptor related to farnesoid X receptor. The Journal of Biological Chemistry. 277: 17836-44. PMID 11867625 DOI: 10.1074/Jbc.M111795200 |
0.397 |
|
| 2002 |
Lee Y, Moore DD. Dual Mechanisms for Repression of the Monomeric Orphan Receptor Liver Receptor Homologous Protein-1 by the Orphan Small Heterodimer Partner Journal of Biological Chemistry. 277: 2463-2467. DOI: 10.1074/Jbc.M105161200 |
0.422 |
|
| 2001 |
Nishizawa H, Yamagata K, Shimomura I, Takahashi M, Kuriyama H, Kishida K, Hotta K, Nagaretani H, Maeda N, Matsuda M, Kihara S, Nakamura T, Nishigori H, Tomura H, Moore DD, et al. Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation. The Journal of Biological Chemistry. 277: 1586-92. PMID 11696534 DOI: 10.1074/Jbc.M104301200 |
0.404 |
|
| 2001 |
Lee YK, Moore DD. Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner. The Journal of Biological Chemistry. 277: 2463-7. PMID 11668176 DOI: 10.1074/jbc.M105161200 |
0.307 |
|
| 2001 |
Tzameli I, Moore DD. Role reversal: new insights from new ligands for the xenobiotic receptor CAR. Trends in Endocrinology and Metabolism: Tem. 12: 7-10. PMID 11137034 DOI: 10.1016/S1043-2760(00)00332-5 |
0.361 |
|
| 2001 |
Pissios P, Tzameli I, Moore DD. New insights into receptor ligand binding domains from a novel assembly assay The Journal of Steroid Biochemistry and Molecular Biology. 76: 3-7. DOI: 10.1016/S0960-0760(00)00144-8 |
0.303 |
|
| 2001 |
Hwang ST, Moore D, Henning SJ. Luminal bile acids influence the developmental expression of ileal bile acid binding protein by activation of the bile acid receptor FXR Gastroenterology. 120. DOI: 10.1016/S0016-5085(08)80607-5 |
0.344 |
|
| 2000 |
Wei P, Zhang J, Egan-Hafley M, Liang S, Moore DD. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature. 407: 920-3. PMID 11057673 DOI: 10.1038/35038112 |
0.311 |
|
| 2000 |
Pissios P, Tzameli I, Kushner PJ, Moore DD. Dynamic stabilization of nuclear receptor ligand binding domains by hormone or corepressor binding Molecular Cell. 6: 245-253. PMID 10983973 DOI: 10.1016/S1097-2765(00)00026-5 |
0.309 |
|
| 2000 |
Tzameli I, Pissios P, Schuetz EG, Moore DD. The Xenobiotic Compound 1,4-Bis(2-(3,5-Dichloropyridyloxy))Benzene Is an Agonist Ligand for the Nuclear Receptor CAR Molecular and Cellular Biology. 20: 2951-2958. PMID 10757780 DOI: 10.1128/Mcb.20.9.2951-2958.2000 |
0.369 |
|
| 2000 |
Laffitte BA, Kast HR, Nguyen CM, Zavacki AM, Moore DD, Edwards PA. Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor. The Journal of Biological Chemistry. 275: 10638-47. PMID 10744760 DOI: 10.1074/Jbc.275.14.10638 |
0.328 |
|
| 2000 |
Urizar NL, Dowhan DH, Moore DD. The Farnesoid X-activated Receptor Mediates Bile Acid Activation of Phospholipid Transfer Protein Gene Expression Journal of Biological Chemistry. 275: 39313-39317. DOI: 10.1074/Jbc.M007998200 |
0.433 |
|
| 1999 |
Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW. Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. Molecular and Cellular Biology. 19: 6323-32. PMID 10454579 DOI: 10.1128/Mcb.19.9.6323 |
0.348 |
|
| 1999 |
Koh YS, Moore DD. Linkage of the nuclear hormone receptor genes NR1D2, THRB, and RARB: evidence for an ancient, large-scale duplication. Genomics. 57: 289-92. PMID 10198169 DOI: 10.1006/Geno.1998.5683 |
0.315 |
|
| 1998 |
Seol W, Hanstein B, Brown M, Moore DD. Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner). Molecular Endocrinology (Baltimore, Md.). 12: 1551-7. PMID 9773978 DOI: 10.1210/Mend.12.10.0184 |
0.355 |
|
| 1994 |
Gulick T, Cresci S, Caira T, Moore DD, Kelly DP. The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proceedings of the National Academy of Sciences of the United States of America. 91: 11012-6. PMID 7971999 DOI: 10.1073/PNAS.91.23.11012 |
0.319 |
|
| 1994 |
Lee JW, Moore DD, Heyman RA. A chimeric thyroid hormone receptor constitutively bound to DNA requires retinoid X receptor for hormone-dependent transcriptional activation in yeast Molecular Endocrinology. 8: 1245-1252. PMID 7838157 DOI: 10.1210/Mend.8.9.7838157 |
0.354 |
|
| 1989 |
Selden RF, Yun JS, Moore DD, Rowe ME, Malia MA, Wagner TE, Goodman HM. Glucocorticoid regulation of human growth hormone expression in transgenic mice and transiently transfected cells. The Journal of Endocrinology. 122: 49-60. PMID 2769161 DOI: 10.1677/Joe.0.1220049 |
0.497 |
|
| 1988 |
Koenig RJ, Warne RL, Brent GA, Harney JW, Larsen PR, Moore DD. Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor Proceedings of the National Academy of Sciences of the United States of America. 85: 5031-5035. PMID 2899322 DOI: 10.1073/Pnas.85.14.5031 |
0.317 |
|
| 1987 |
Koenig RJ, Brent GA, Warne RL, Larsen PR, Moore DD. Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone Proceedings of the National Academy of Sciences of the United States of America. 84: 5670-5674. PMID 3475698 DOI: 10.1073/Pnas.84.16.5670 |
0.325 |
|
| 1986 |
Larsen PR, Harney JW, Moore DD. Repression mediates cell-type-specific expression of the rat growth hormone gene. Proceedings of the National Academy of Sciences of the United States of America. 83: 8283-7. PMID 3464954 DOI: 10.1073/Pnas.83.21.8283 |
0.301 |
|
| 1986 |
Selden RF, Howie KB, Rowe ME, Goodman HM, Moore DD. Human growth hormone as a reporter gene in regulation studies employing transient gene expression. Molecular and Cellular Biology. 6: 3173-9. PMID 3023965 DOI: 10.1128/MCB.6.9.3173 |
0.448 |
|
| 1986 |
Marks AR, Moore DD, Buckley DI, Gametchu B, Goodman HM. Conservation of the DNA binding domain and other properties between porcine and rat glucocorticoid receptors. Journal of Steroid Biochemistry. 24: 1097-103. PMID 3016408 DOI: 10.1016/0022-4731(86)90369-9 |
0.43 |
|
| 1985 |
Moore DD, Marks AR, Buckley DI, Kapler G, Payvar F, Goodman HM. The first intron of the human growth hormone gene contains a binding site for glucocorticoid receptor. Proceedings of the National Academy of Sciences of the United States of America. 82: 699-702. PMID 2983311 DOI: 10.1073/Pnas.82.3.699 |
0.503 |
|
| 1982 |
Moore DD, Conkling MA, Goodman HM. Human growth hormone: a multigene family. Cell. 29: 285-6. PMID 7116443 DOI: 10.1016/0092-8674(82)90144-1 |
0.449 |
|
| 1982 |
Moore DD, Walker MD, Diamond DJ, Conkling MA, Goodman HM. Structure, expression, and evolution of growth hormone genes. Recent Progress in Hormone Research. 38: 197-225. PMID 6289392 DOI: 10.1016/B978-0-12-571138-8.50010-X |
0.422 |
|
| 1981 |
Moore DD, Denniston KJ, Blattner FR. Sequence organization of the origins of DNA replication in lambdoid coliphages. Gene. 14: 91-101. PMID 6455332 DOI: 10.1016/0378-1119(81)90151-7 |
0.413 |
|
| 1980 |
Schumm JW, Moore DD, Blattner FR, Howe MM. Correlation of the genetic and physical maps in the central region of the bacteriophage Mu genome. Virology. 105: 185-95. PMID 6251604 DOI: 10.1016/0042-6822(80)90166-X |
0.409 |
|
| 1980 |
de Wet JR, Daniels DL, Schroeder JL, Williams BG, Denniston-Thompson K, Moore DD, Blattner FR. Restriction maps for twenty-one Charon vector phages. Journal of Virology. 33: 401-410. DOI: 10.1128/jvi.33.1.401-410.1980 |
0.376 |
|
| 1979 |
Moore DD, Denniston-Thompson K, Kruger KE, Furth ME, Williams BG, Daniels DL, Blattner FR. Dissection and comparative anatomy of the origins of replication of lambdoid phages. Cold Spring Harbor Symposia On Quantitative Biology. 155-63. PMID 157834 DOI: 10.1101/SQB.1979.043.01.022 |
0.38 |
|
| 1978 |
Denniston-Thompson K, Moore DD, Kruger KE, Furth ME, Blattner FR. Physical structure of the replication origin of bacteriophage lambda. Science (New York, N.Y.). 198: 1051-6. PMID 929187 DOI: 10.1126/Science.929187 |
0.409 |
|
| 1978 |
Moore DD, Denniston-Thompson K, Furth ME, Williams BG, Blattner FR. Construction of chimeric phages and plasmids containing the origin of replication of bacteriophage lambda. Science (New York, N.Y.). 198: 1041-6. PMID 929185 DOI: 10.1126/Science.929185 |
0.397 |
|
| 1977 |
Blattner FR, Williams BG, Blechl AE, Denniston-Thompson K, Faber HE, Furlong L, Grunwald DJ, Kiefer DO, Moore DD, Schumm JW, Sheldon EL, Smithies O. Charon phages: safer derivatives of bacteriophage lambda for DNA cloning. Science (New York, N.Y.). 196: 161-9. PMID 847462 DOI: 10.1126/Science.847462 |
0.4 |
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