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Sohum Mehta, Ph.D. - Publications

Affiliations: 
2010 Johns Hopkins University, Baltimore, MD 
Area:
Cell Biology, Genetics, Molecular Biology
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50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Su Q, Zhang J, Lin W, Zhang JF, Newton AC, Mehta S, Yang J, Zhang J. Sensitive fluorescent biosensor reveals differential subcellular regulation of PKC. Nature Chemical Biology. PMID 39394268 DOI: 10.1038/s41589-024-01758-3  0.321
2024 Lin W, Phatarphekar A, Zhong Y, Liu L, Kwon HB, Gerwick WH, Wang Y, Mehta S, Zhang J. Light-gated integrator for highlighting kinase activity in living cells. Nature Communications. 15: 7804. PMID 39242543 DOI: 10.1038/s41467-024-51270-4  0.383
2024 Su Q, Zhang J, Lin W, Zhang JF, Newton AC, Mehta S, Yang J, Zhang J. Sensitive Fluorescent Biosensor Reveals Differential Subcellular Regulation of PKC. Biorxiv : the Preprint Server For Biology. PMID 38586003 DOI: 10.1101/2024.03.29.587373  0.344
2024 Lin W, Phatarphekar A, Zhong Y, Liu L, Kwon HB, Gerwick WH, Wang Y, Mehta S, Zhang J. Light-gated Integrator for Highlighting Kinase Activity in Living Cells. Biorxiv : the Preprint Server For Biology. PMID 38562887 DOI: 10.1101/2024.03.18.585554  0.393
2024 Hardy JC, Pool EH, Bruystens JGH, Zhou X, Li Q, Zhou DR, Palay M, Tan G, Chen L, Choi JLC, Lee HN, Strack S, Wang D, Taylor SS, Mehta S, et al. Molecular determinants and signaling effects of PKA RIα phase separation. Molecular Cell. PMID 38537638 DOI: 10.1016/j.molcel.2024.03.002  0.337
2023 Hardy JC, Pool EH, Bruystens JGH, Zhou X, Li Q, Zhou DR, Palay M, Tan G, Chen L, Choi JLC, Lee HN, Strack S, Wang D, Taylor SS, Mehta S, et al. Molecular Determinants and Signaling Effects of PKA RIα Phase Separation. Biorxiv : the Preprint Server For Biology. PMID 38168176 DOI: 10.1101/2023.12.10.570836  0.333
2023 Lyons AC, Mehta S, Zhang J. Fluorescent biosensors illuminate the spatial regulation of cell signaling across scales. The Biochemical Journal. 480: 1693-1717. PMID 37903110 DOI: 10.1042/BCJ20220223  0.38
2023 Posner C, Mehta S, Zhang J. Fluorescent biosensor imaging meets deterministic mathematical modelling: quantitative investigation of signalling compartmentalization. The Journal of Physiology. 601: 4227-4241. PMID 37747358 DOI: 10.1113/JP282696  0.369
2022 Schmitt DL, Mehta S, Zhang J. Study of spatiotemporal regulation of kinase signaling using genetically encodable molecular tools. Current Opinion in Chemical Biology. 71: 102224. PMID 36347198 DOI: 10.1016/j.cbpa.2022.102224  0.339
2022 Kwon Y, Mehta S, Clark M, Walters G, Zhong Y, Lee HN, Sunahara RK, Zhang J. Non-canonical β-adrenergic activation of ERK at endosomes. Nature. PMID 36289326 DOI: 10.1038/s41586-022-05343-3  0.354
2022 Schmitt DL, Curtis SD, Lyons AC, Zhang JF, Chen M, He CY, Mehta S, Shaw RJ, Zhang J. Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter. Nature Communications. 13: 3856. PMID 35790710 DOI: 10.1038/s41467-022-31190-x  0.322
2022 Zhou X, Mehta S, Zhang J. AktAR and Akt-STOPS: Genetically Encodable Molecular Tools to Visualize and Perturb Akt Kinase Activity at Different Subcellular Locations in Living Cells. Current Protocols. 2: e416. PMID 35532280 DOI: 10.1002/cpz1.416  0.363
2022 Hardy JC, Mehta S, Zhang J. Measuring Spatiotemporal cAMP Dynamics Within an Endogenous Signaling Compartment Using FluoSTEP-ICUE. Methods in Molecular Biology (Clifton, N.J.). 2483: 351-366. PMID 35286687 DOI: 10.1007/978-1-0716-2245-2_22  0.361
2021 Su Q, Mehta S, Zhang J. Liquid-liquid phase separation: Orchestrating cell signaling through time and space. Molecular Cell. PMID 34619090 DOI: 10.1016/j.molcel.2021.09.010  0.332
2021 Keyes J, Mehta S, Zhang J. Strategies for Multiplexed Biosensor Imaging to Study Intracellular Signaling Networks. Methods in Molecular Biology (Clifton, N.J.). 2350: 1-20. PMID 34331275 DOI: 10.1007/978-1-0716-1593-5_1  0.37
2021 Tenner B, Zhang JZ, Kwon Y, Pessino V, Feng S, Huang B, Mehta S, Zhang J. FluoSTEPs: Fluorescent biosensors for monitoring compartmentalized signaling within endogenous microdomains. Science Advances. 7. PMID 34020947 DOI: 10.1126/sciadv.abe4091  0.396
2021 Mehta S, Zhang J. Biochemical Activity Architectures Visualized-Using Genetically Encoded Fluorescent Biosensors to Map the Spatial Boundaries of Signaling Compartments. Accounts of Chemical Research. PMID 33949851 DOI: 10.1021/acs.accounts.1c00056  0.414
2021 Zhang JF, Mehta S, Zhang J. Signaling Microdomains in the Spotlight: Visualizing Compartmentalized Signaling Using Genetically Encoded Fluorescent Biosensors. Annual Review of Pharmacology and Toxicology. 61: 587-608. PMID 33411579 DOI: 10.1146/annurev-pharmtox-010617-053137  0.402
2020 Zhang JF, Liu B, Hong I, Mo A, Roth RH, Tenner B, Lin W, Zhang JZ, Molina RS, Drobizhev M, Hughes TE, Tian L, Huganir RL, Mehta S, Zhang J. An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice. Nature Chemical Biology. PMID 32989297 DOI: 10.1038/s41589-020-00660-y  0.378
2020 Zhang JZ, Lu TW, Stolerman LM, Tenner B, Yang JR, Zhang JF, Falcke M, Rangamani P, Taylor SS, Mehta S, Zhang J. Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling. Cell. PMID 32846158 DOI: 10.1016/J.Cell.2020.07.043  0.451
2020 Zhou X, Mehta S, Zhang J. Genetically Encodable Fluorescent and Bioluminescent Biosensors Light Up Signaling Networks. Trends in Biochemical Sciences. PMID 32660810 DOI: 10.1016/J.Tibs.2020.06.001  0.437
2020 Lee HN, Mehta S, Zhang J. Recent advances in the use of genetically encodable optical tools to elicit and monitor signaling events. Current Opinion in Cell Biology. 63: 114-124. PMID 32058267 DOI: 10.1016/J.Ceb.2020.01.007  0.466
2020 Schmitt DL, Mehta S, Zhang J. Illuminating the kinome: Visualizing real-time kinase activity in biological systems using genetically encoded fluorescent protein-based biosensors. Current Opinion in Chemical Biology. 54: 63-69. PMID 31911398 DOI: 10.1016/J.Cbpa.2019.11.005  0.403
2020 Mehta S, Zhang J, Liu B, Hong I, Tenner B, Lin W, Huganir RL, Zhang J. An Ultrasensitive Fluorescent Biosensor for Multi‐modal Kinase Activity Detection and High‐resolution Imaging in Awake Mice The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04082  0.325
2020 Zhang JZ, Lu T, Tenner B, Yang J, Zhang J, Taylor S, Mehta S, Zhang J. PKA RIα phase separation drives cAMP compartmentation and suppresses tumorigenic signaling The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03204  0.353
2020 Schmitt DL, Zhang J, Chen M, Leung A, He CY, Curtis SD, Mehta S, Shaw RJ, Rangamani P, Zhang J. Illuminating Spatiotemporal Regulation of AMPK with a Genetically Encoded Excitation‐Ratiometric Biosensor for AMPK The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03063  0.328
2019 Hertel F, Li S, Chen M, Pott L, Mehta S, Zhang J. Fluorescent biosensors for multiplexed imaging of phosphoinositide dynamics. Acs Chemical Biology. PMID 31855412 DOI: 10.1021/Acschembio.9B00691  0.407
2019 Lin W, Mehta S, Zhang J. Genetically encoded fluorescent biosensors illuminate kinase signaling in cancer. The Journal of Biological Chemistry. PMID 31434714 DOI: 10.1074/Jbc.Rev119.006177  0.468
2019 Qian Y, Piatkevich KD, Mc Larney B, Abdelfattah AS, Mehta S, Murdock MH, Gottschalk S, Molina RS, Zhang W, Chen Y, Wu J, Drobizhev M, Hughes TE, Zhang J, Schreiter ER, et al. A genetically encoded near-infrared fluorescent calcium ion indicator. Nature Methods. PMID 30664778 DOI: 10.1038/S41592-018-0294-6  0.305
2018 Greenwald EC, Mehta S, Zhang J. Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks. Chemical Reviews. PMID 30550275 DOI: 10.1021/Acs.Chemrev.8B00333  0.458
2018 Mehta S, Zhang Y, Roth RH, Zhang JF, Mo A, Tenner B, Huganir RL, Zhang J. Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities. Nature Cell Biology. 20: 1215-1225. PMID 30250062 DOI: 10.1038/S41556-018-0200-6  0.455
2018 Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J. A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling. Cell Reports. 24: 3312-3323.e5. PMID 30232011 DOI: 10.1016/J.Celrep.2018.08.061  0.38
2017 Nygren PJ, Mehta S, Schweppe DK, Langeberg LK, Whiting JL, Weisbrod CR, Bruce JE, Zhang J, Veesler D, Scott JD. Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. Elife. 6. PMID 28967377 DOI: 10.7554/Elife.30872  0.327
2017 Mehta S, Zhang J. Illuminating the cell's biochemical activity architecture. Biochemistry. PMID 28718621 DOI: 10.1021/Acs.Biochem.7B00561  0.394
2017 Ni Q, Mehta S, Zhang J. Live-cell imaging of cell signaling using genetically encoded fluorescent reporters. The Febs Journal. PMID 28613457 DOI: 10.1111/Febs.14134  0.467
2017 Gorshkov K, Mehta S, Ramamurthy S, Ronnett GV, Zhou FQ, Zhang J. AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nature Chemical Biology. PMID 28192412 DOI: 10.1038/Nchembio.2298  0.309
2016 Ross B, Mehta S, Zhang J. Molecular tools for acute spatiotemporal manipulation of signal transduction. Current Opinion in Chemical Biology. 34: 135-142. PMID 27639090 DOI: 10.1016/J.Cbpa.2016.08.012  0.439
2016 Tenner B, Mehta S, Zhang J. Optical sensors to gain mechanistic insights into signaling assemblies. Current Opinion in Structural Biology. 41: 203-210. PMID 27611602 DOI: 10.1016/J.Sbi.2016.07.021  0.426
2015 Depry C, Mehta S, Li R, Zhang J. Visualization of Compartmentalized Kinase Activity Dynamics Using Adaptable BimKARs. Chemistry & Biology. PMID 26548610 DOI: 10.1016/J.Chembiol.2015.10.004  0.388
2015 Mehta S, Zhang J. Dynamic visualization of calcium-dependent signaling in cellular microdomains. Cell Calcium. PMID 25703691 DOI: 10.1016/J.Ceca.2015.01.009  0.451
2015 Clister T, Mehta S, Zhang J. Single-cell analysis of G-protein signal transduction. The Journal of Biological Chemistry. 290: 6681-8. PMID 25605723 DOI: 10.1074/Jbc.R114.616391  0.457
2014 Mehta S, Aye-Han NN, Ganesan A, Oldach L, Gorshkov K, Zhang J. Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin. Elife. 3: e03765. PMID 25056880 DOI: 10.7554/Elife.03765  0.434
2014 Sample V, Mehta S, Zhang J. Genetically encoded molecular probes to visualize and perturb signaling dynamics in living biological systems. Journal of Cell Science. 127: 1151-60. PMID 24634506 DOI: 10.1242/Jcs.099994  0.451
2014 Mehta S, Zhang J. Using a genetically encoded FRET-based reporter to visualize calcineurin phosphatase activity in living cells. Methods in Molecular Biology (Clifton, N.J.). 1071: 139-49. PMID 24052386 DOI: 10.1007/978-1-62703-622-1_11  0.413
2014 Mehta S, Aye-Han N, Ganesan A, Oldach L, Gorshkov K, Zhang J. Author response: Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin Elife. DOI: 10.7554/Elife.03765.018  0.336
2013 Mehta S, Zhang J. Using a kinase-inducible bimolecular switch to control enzyme activity in living cells. Current Protocols in Chemical Biology. 5: 227-37. PMID 24391085 DOI: 10.1002/9780470559277.Ch130090  0.394
2013 Depry C, Mehta S, Zhang J. Multiplexed visualization of dynamic signaling networks using genetically encoded fluorescent protein-based biosensors Pflugers Archiv European Journal of Physiology. 465: 373-381. PMID 23138230 DOI: 10.1007/S00424-012-1175-Y  0.478
2013 Sample V, Ni Q, Mehta S, Inoue T, Zhang J. Controlling enzymatic action in living cells with a kinase-inducible bimolecular switch Acs Chemical Biology. 8: 116-121. PMID 23072367 DOI: 10.1021/Cb300393W  0.434
2011 Mehta S, Zhang J. Reporting from the field: Genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems Annual Review of Biochemistry. 80: 375-401. PMID 21495849 DOI: 10.1146/Annurev-Biochem-060409-093259  0.436
2009 Mehta S, Li H, Hogan PG, Cunningham KW. Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in yeast. Molecular and Cellular Biology. 29: 2777-93. PMID 19273587 DOI: 10.1128/Mcb.01197-08  0.545
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