| Year |
Citation |
Score |
| 2024 |
Newman LE, Weiser Novak S, Rojas GR, Tadepalle N, Schiavon CR, Grotjahn DA, Towers CG, Tremblay MÈ, Donnelly MP, Ghosh S, Medina M, Rocha S, Rodriguez-Enriquez R, Chevez JA, Lemersal I, ... ... Shadel GS, et al. Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal. Nature Cell Biology. 26: 194-206. PMID 38332353 DOI: 10.1038/s41556-023-01343-1 |
0.508 |
|
| 2023 |
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, ... ... Shadel GS, et al. Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature. 622: 627-636. PMID 37821702 DOI: 10.1038/s41586-023-06621-4 |
0.53 |
|
| 2023 |
Mangalhara KC, Varanasi SK, Johnson MA, Burns MJ, Rojas GR, Esparza Moltó PB, Sainz AG, Tadepalle N, Abbott KL, Mendiratta G, Chen D, Farsakoglu Y, Kunchok T, Hoffmann FA, Parisi B, ... ... Shadel GS, et al. Manipulating mitochondrial electron flow enhances tumor immunogenicity. Science (New York, N.Y.). 381: 1316-1323. PMID 37733872 DOI: 10.1126/science.abq1053 |
0.364 |
|
| 2023 |
Lei Y, VanPortfliet JJ, Chen YF, Bryant JD, Li Y, Fails D, Torres-Odio S, Ragan KB, Deng J, Mohan A, Wang B, Brahms ON, Yates SD, Spencer M, Tong CW, ... ... Shadel GS, et al. Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity. Cell. PMID 37352855 DOI: 10.1016/j.cell.2023.05.039 |
0.473 |
|
| 2023 |
Al Khatib I, Deng J, Lei Y, Torres-Odio S, Rojas GR, Newman LE, Chung BK, Symes A, Zhang H, Huang SN, Pommier Y, Khan A, Shadel GS, West AP, Gibson WT, et al. Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT. Human Molecular Genetics. PMID 37129502 DOI: 10.1093/hmg/ddad062 |
0.412 |
|
| 2023 |
Malik N, Ferreira BI, Hollstein PE, Curtis SD, Trefts E, Weiser Novak S, Yu J, Gilson R, Hellberg K, Fang L, Sheridan A, Hah N, Shadel GS, Manor U, Shaw RJ. Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1. Science (New York, N.Y.). 380: eabj5559. PMID 37079666 DOI: 10.1126/science.abj5559 |
0.506 |
|
| 2023 |
Newman LE, Shadel GS. Mitochondrial DNA Release in Innate Immune Signaling. Annual Review of Biochemistry. PMID 37001140 DOI: 10.1146/annurev-biochem-032620-104401 |
0.456 |
|
| 2023 |
Nassour J, Aguiar LG, Correia A, Schmidt TT, Mainz L, Przetocka S, Haggblom C, Tadepalle N, Williams A, Shokhirev MN, Akincilar SC, Tergaonkar V, Shadel GS, Karlseder J. Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis. Nature. PMID 36755096 DOI: 10.1038/s41586-023-05710-8 |
0.44 |
|
| 2022 |
Cobo I, Tanaka TN, Chandra Mangalhara K, Lana A, Yeang C, Han C, Schlachetzki J, Challcombe J, Fixsen BR, Sakai M, Li RZ, Fields H, Mokry M, Tsai RG, Bejar R, ... ... Shadel GS, et al. DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages. Immunity. PMID 35931086 DOI: 10.1016/j.immuni.2022.06.022 |
0.416 |
|
| 2022 |
Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. PMID 35835107 DOI: 10.1016/j.immuni.2022.06.007 |
0.455 |
|
| 2022 |
Hepokoski ML, Odish MF, Lam MT, Coufal NG, Rolfsen ML, Shadel GS, Moyzis AG, Sainz AG, Takiar PG, Patel S, Leonard AJ, Samandari N, Hansen E, Trescott S, Nguyen C, et al. Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 35699291 DOI: 10.1152/ajplung.00128.2022 |
0.423 |
|
| 2021 |
Wu Z, Sainz AG, Shadel GS. Mitochondrial DNA: cellular genotoxic stress sentinel. Trends in Biochemical Sciences. PMID 34088564 DOI: 10.1016/j.tibs.2021.05.004 |
0.469 |
|
| 2021 |
Tadepalle N, Shadel GS. RNA reports breaking news from mitochondria. Molecular Cell. 81: 1863-1865. PMID 33961775 DOI: 10.1016/j.molcel.2021.04.005 |
0.324 |
|
| 2021 |
Schwartz RE, Shokhirev MN, Andrade LR, Gutkind JS, Iglesias-Bartolome R, Shadel GS. Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes. Aging. 13. PMID 33601339 DOI: 10.18632/aging.202658 |
0.315 |
|
| 2021 |
Schiavon CR, Shadel GS, Manor U. Impaired Mitochondrial Mobility in Charcot-Marie-Tooth Disease. Frontiers in Cell and Developmental Biology. 9: 624823. PMID 33598463 DOI: 10.3389/fcell.2021.624823 |
0.351 |
|
| 2019 |
Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, ... Shadel GS, et al. Mitochondrial DNA Stress Signalling Protects the Nuclear Genome. Nature Metabolism. 1: 1209-1218. PMID 32395698 DOI: 10.1038/s42255-019-0150-8 |
0.468 |
|
| 2019 |
Gale M, Li Y, Cao J, Liu ZZ, Holmbeck MA, Zhang M, Lang SM, Wu L, Do Carmo M, Gupta S, Aoshima K, DiGiovanna MP, Stern DF, Rimm DL, Shadel GS, et al. Acquired resistance to HER2-targeted therapies creates vulnerability to ATP synthase inhibition. Cancer Research. PMID 31690671 DOI: 10.1158/0008-5472.Can-18-3985 |
0.337 |
|
| 2019 |
Harel M, Ortenberg R, Varanasi SK, Mangalhara KC, Mardamshina M, Markovits E, Baruch EN, Tripple V, Arama-Chayoth M, Greenberg E, Shenoy A, Ayasun R, Knafo N, Xu S, Anafi L, ... ... Shadel GS, et al. Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence. Cell. PMID 31495571 DOI: 10.1016/J.Cell.2019.08.012 |
0.335 |
|
| 2018 |
Mangalhara KC, Shadel GS. A Mitochondrial-Derived Peptide Exercises the Nuclear Option. Cell Metabolism. 28: 330-331. PMID 30184481 DOI: 10.1016/J.Cmet.2018.08.017 |
0.561 |
|
| 2018 |
Newman LE, Shadel GS. Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration. The Journal of Cell Biology. PMID 30154188 DOI: 10.1083/Jcb.201808118 |
0.501 |
|
| 2018 |
Cox CS, McKay SE, Holmbeck MA, Christian BE, Scortea AC, Tsay AJ, Newman LE, Shadel GS. Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling. Cell Metabolism. PMID 30122556 DOI: 10.1016/J.Cmet.2018.07.011 |
0.577 |
|
| 2018 |
Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, ... ... Shadel GS, et al. KDM5 histone demethylases repress immune response via suppression of STING. Plos Biology. 16: e2006134. PMID 30080846 DOI: 10.1371/Journal.Pbio.2006134 |
0.312 |
|
| 2018 |
Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS. Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity. Science Signaling. 11. PMID 29991649 DOI: 10.1126/Scisignal.Aaq0702 |
0.551 |
|
| 2018 |
Chen Y, Rachek L, Shadel G, Mehal WZ. 515 - Oxidized Mitochondrial DNA Induces Steatohepatitis through CGAS Signaling Pathway Gastroenterology. 154: S-1096. DOI: 10.1016/s0016-5085(18)33649-7 |
0.42 |
|
| 2017 |
Kuszak AJ, Espey MG, Falk MJ, Holmbeck MA, Manfredi G, Shadel GS, Vernon HJ, Zolkipli-Cunningham Z. Nutritional Interventions for Mitochondrial OXPHOS Deficiencies: Mechanisms and Model Systems. Annual Review of Pathology. PMID 29099651 DOI: 10.1146/Annurev-Pathol-020117-043644 |
0.409 |
|
| 2017 |
West AP, Shadel GS. Mitochondrial DNA in innate immune responses and inflammatory pathology. Nature Reviews. Immunology. PMID 28393922 DOI: 10.1038/Nri.2017.21 |
0.513 |
|
| 2017 |
Schweppe DK, Chavez JD, Lee CF, Caudal A, Kruse SE, Stuppard R, Marcinek DJ, Shadel GS, Tian R, Bruce JE. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. PMID 28130547 DOI: 10.1073/Pnas.1617220114 |
0.51 |
|
| 2016 |
Kang MJ, Shadel GS. A Mitochondrial Perspective of Chronic Obstructive Pulmonary Disease Pathogenesis. Tuberculosis and Respiratory Diseases. 79: 207-213. PMID 27790272 DOI: 10.4046/Trd.2016.79.4.207 |
0.351 |
|
| 2016 |
Oran AR, Adams CM, Zhang XY, Gennaro VJ, Pfeiffer HK, Mellert HS, Seidel HE, Mascioli K, Kaplan J, Gaballa MR, Shen C, Rigoutsos I, King MP, Cotney JL, Arnold JJ, ... ... Shadel GS, et al. Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. Oncotarget. PMID 27590350 DOI: 10.18632/Oncotarget.11718 |
0.816 |
|
| 2016 |
Holmbeck MA, Shadel GS. Mitochondria provide a 'complex' solution to a bacterial problem. Nature Immunology. 17: 1009-10. PMID 27540983 DOI: 10.1038/Ni.3534 |
0.486 |
|
| 2016 |
Taylor A, Adams C, Zhang X, Gennaro V, Cotney J, Shadel G, Cameron C, Eischen C, McMahon S. Abstract 1256: Multi-focal control of mitochondrial gene expression by oncogenic MYC provides effective therapeutic targets in cancer Cancer Research. 76: 1256-1256. DOI: 10.1158/1538-7445.Am2016-1256 |
0.805 |
|
| 2016 |
Shadel GS. Mitochondrial DNA stress in innate immune signalling and cancer Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1857: e5-e6. DOI: 10.1016/J.Bbabio.2016.04.408 |
0.451 |
|
| 2015 |
Nouws J, Goswami AV, Bestwick M, McCann BJ, Surovtseva YV, Shadel GS. Mitochondrial Ribosomal Protein L12 is required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis During Import. The Journal of Biological Chemistry. PMID 26586915 DOI: 10.1074/Jbc.M115.689299 |
0.855 |
|
| 2015 |
McKay SE, Yan W, Nouws J, Thormann MJ, Raimundo N, Khan A, Santos-Sacchi J, Song L, Shadel GS. Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness. The American Journal of Pathology. PMID 26552864 DOI: 10.1016/J.Ajpath.2015.08.014 |
0.533 |
|
| 2015 |
Shadel GS, Horvath TL. Mitochondrial ROS Signaling in Organismal Homeostasis. Cell. 163: 560-9. PMID 26496603 DOI: 10.1016/J.Cell.2015.10.001 |
0.535 |
|
| 2015 |
West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 520: 553-7. PMID 25642965 DOI: 10.1038/Nature14156 |
0.55 |
|
| 2015 |
Taylor A, Zhang X, Cotney J, Shadel G, Cameron C, McMahon S. Abstract A05: The mitochondrial RNA polymerase is an essential downstream effector of the MYC oncoprotein Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-A05 |
0.827 |
|
| 2014 |
Shadel GS. Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging. Microbial Cell (Graz, Austria). 1: 140-144. PMID 28357235 DOI: 10.15698/Mic2014.05.143 |
0.535 |
|
| 2014 |
Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell. 159: 1563-77. PMID 25525875 DOI: 10.1016/J.Cell.2014.11.037 |
0.517 |
|
| 2014 |
Clayton DA, Shadel GS. Isolation of mitochondria from cells and tissues. Cold Spring Harbor Protocols. 2014: pdb.top074542. PMID 25275115 DOI: 10.1101/Pdb.Top074542 |
0.484 |
|
| 2014 |
Clayton DA, Shadel GS. Purification of mitochondria by sucrose step density gradient centrifugation. Cold Spring Harbor Protocols. 2014: pdb.prot080028. PMID 25275106 DOI: 10.1101/Pdb.Prot080028 |
0.44 |
|
| 2014 |
Clayton DA, Shadel GS. Isolation of mitochondria from animal tissue. Cold Spring Harbor Protocols. 2014: pdb.prot080010. PMID 25275105 DOI: 10.1101/Pdb.Prot080010 |
0.461 |
|
| 2014 |
Clayton DA, Shadel GS. Isolation of mitochondria from tissue culture cells. Cold Spring Harbor Protocols. 2014: pdb.prot080002. PMID 25275104 DOI: 10.1101/Pdb.Prot080002 |
0.337 |
|
| 2014 |
Nouws J, Shadel GS. microManaging mitochondrial translation. Cell. 158: 477-8. PMID 25083863 DOI: 10.1016/J.Cell.2014.07.010 |
0.563 |
|
| 2014 |
Christian BE, Shadel GS. Aging: it's SIRTainly possible to restore mitochondrial dysfunction. Current Biology : Cb. 24: R206-8. PMID 24602889 DOI: 10.1016/J.Cub.2014.01.027 |
0.61 |
|
| 2014 |
Mannam P, Shinn AS, Srivastava A, Neamu RF, Walker WE, Bohanon M, Merkel J, Kang MJ, Dela Cruz CS, Ahasic AM, Pisani MA, Trentalange M, West AP, Shadel GS, Elias JA, et al. MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 306: L604-19. PMID 24487387 DOI: 10.1152/Ajplung.00272.2013 |
0.617 |
|
| 2014 |
Schroeder EA, Shadel GS. Crosstalk between mitochondrial stress signals regulates yeast chronological lifespan. Mechanisms of Ageing and Development. 135: 41-9. PMID 24373996 DOI: 10.1016/J.Mad.2013.12.002 |
0.624 |
|
| 2014 |
Sharma NK, Lebedeva M, Thomas T, Kovalenko OA, Stumpf JD, Shadel GS, Santos JH. Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia. Dna Repair. 13: 22-31. PMID 24342190 DOI: 10.1016/J.Dnarep.2013.11.002 |
0.502 |
|
| 2014 |
Shadel G. Mitochondrial stress signaling in disease and aging (474.3) The Faseb Journal. 28. DOI: 10.1096/Fasebj.28.1_Supplement.474.3 |
0.478 |
|
| 2014 |
Shadel GS. Mitochondrial stress signaling in disease and aging Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1837: e8. DOI: 10.1016/j.bbabio.2014.05.132 |
0.389 |
|
| 2013 |
Schroeder EA, Raimundo N, Shadel GS. Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metabolism. 17: 954-64. PMID 23747251 DOI: 10.1016/J.Cmet.2013.04.003 |
0.541 |
|
| 2013 |
Bestwick ML, Shadel GS. Accessorizing the human mitochondrial transcription machinery. Trends in Biochemical Sciences. 38: 283-91. PMID 23632312 DOI: 10.1016/J.Tibs.2013.03.006 |
0.655 |
|
| 2013 |
Surovtseva YV, Shadel GS. Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis. Nucleic Acids Research. 41: 2479-88. PMID 23303773 DOI: 10.1093/Nar/Gks1447 |
0.695 |
|
| 2013 |
D'Souza AD, Parish IA, Krause DS, Kaech SM, Shadel GS. Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 42-8. PMID 23011031 DOI: 10.1038/Mt.2012.203 |
0.529 |
|
| 2013 |
Suissa S, Wang Z, Poole J, Wittkopp S, Feder J, Shutt TE, Wallace DC, Shadel GS, Mishmar D. Run-off in vitro transcription assays preformed using mtDNA templates with or without TFAM binding site variants. Plos Genetics. DOI: 10.1371/Journal.Pgen.1000474.G003 |
0.371 |
|
| 2012 |
Ocampo A, Liu J, Schroeder EA, Shadel GS, Barrientos A. Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction. Cell Metabolism. 16: 55-67. PMID 22768839 DOI: 10.1016/J.Cmet.2012.05.013 |
0.526 |
|
| 2012 |
Longo VD, Shadel GS, Kaeberlein M, Kennedy B. Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metabolism. 16: 18-31. PMID 22768836 DOI: 10.1016/J.Cmet.2012.06.002 |
0.305 |
|
| 2012 |
Lodeiro MF, Uchida A, Bestwick M, Moustafa IM, Arnold JJ, Shadel GS, Cameron CE. Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro. Proceedings of the National Academy of Sciences of the United States of America. 109: 6513-8. PMID 22493245 DOI: 10.1073/Pnas.1118710109 |
0.519 |
|
| 2012 |
Schroeder EA, Shadel GS. Alternative mitochondrial fuel extends life span. Cell Metabolism. 15: 417-8. PMID 22482723 DOI: 10.1016/J.Cmet.2012.03.011 |
0.47 |
|
| 2012 |
Raimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS. Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness. Cell. 148: 716-26. PMID 22341444 DOI: 10.1016/J.Cell.2011.12.027 |
0.816 |
|
| 2012 |
Woo DK, Green PD, Santos JH, D'Souza AD, Walther Z, Martin WD, Christian BE, Chandel NS, Shadel GS. Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. The American Journal of Pathology. 180: 24-31. PMID 22056359 DOI: 10.1016/J.Ajpath.2011.10.003 |
0.624 |
|
| 2012 |
Malarkey CS, Bestwick M, Kuhlwilm JE, Shadel GS, Churchill ME. Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA. Nucleic Acids Research. 40: 614-24. PMID 21948790 DOI: 10.1093/Nar/Gkr787 |
0.482 |
|
| 2012 |
Shadel G. MITOCHONDRIAL STRESS SIGNALING IN DISEASE AND AGING Free Radical Biology and Medicine. 53: S2. DOI: 10.1016/J.Bbabio.2014.05.132 |
0.488 |
|
| 2011 |
Surovtseva YV, Shutt TE, Cotney J, Cimen H, Chen SY, Koc EC, Shadel GS. Mitochondrial ribosomal protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription. Proceedings of the National Academy of Sciences of the United States of America. 108: 17921-6. PMID 22003127 DOI: 10.1073/Pnas.1108852108 |
0.828 |
|
| 2011 |
Liu L, Sanosaka M, Lei S, Bestwick ML, Frey JH, Surovtseva YV, Shadel GS, Cooper MP. LRP130 protein remodels mitochondria and stimulates fatty acid oxidation. The Journal of Biological Chemistry. 286: 41253-64. PMID 21971050 DOI: 10.1074/Jbc.M111.276121 |
0.642 |
|
| 2011 |
Baysal BE, McKay SE, Kim YJ, Zhang Z, Alila L, Willett-Brozick JE, Pacak K, Kim TH, Shadel GS. Genomic imprinting at a boundary element flanking the SDHD locus. Human Molecular Genetics. 20: 4452-61. PMID 21862453 DOI: 10.1093/Hmg/Ddr376 |
0.335 |
|
| 2011 |
Raimundo N, Baysal BE, Shadel GS. Revisiting the TCA cycle: signaling to tumor formation. Trends in Molecular Medicine. 17: 641-9. PMID 21764377 DOI: 10.1016/J.Molmed.2011.06.001 |
0.401 |
|
| 2011 |
Chatenay-Lapointe M, Shadel GS. Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p. Plos One. 6: e20441. PMID 21655263 DOI: 10.1371/Journal.Pone.0020441 |
0.697 |
|
| 2011 |
Pan Y, Schroeder EA, Ocampo A, Barrientos A, Shadel GS. Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metabolism. 13: 668-78. PMID 21641548 DOI: 10.1016/J.Cmet.2011.03.018 |
0.607 |
|
| 2011 |
West AP, Shadel GS, Ghosh S. Mitochondria in innate immune responses. Nature Reviews. Immunology. 11: 389-402. PMID 21597473 DOI: 10.1038/Nri2975 |
0.349 |
|
| 2011 |
West AP, Brodsky IE, Rahner C, Woo DK, Erdjument-Bromage H, Tempst P, Walsh MC, Choi Y, Shadel GS, Ghosh S. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature. 472: 476-80. PMID 21525932 DOI: 10.1038/Nature09973 |
0.529 |
|
| 2011 |
Shutt TE, Bestwick M, Shadel GS. The core human mitochondrial transcription initiation complex: It only takes two to tango. Transcription. 2: 55-59. PMID 21468229 DOI: 10.4161/trns.2.2.14296 |
0.42 |
|
| 2011 |
Woo DK, Shadel GS. Mitochondrial stress signals revise an old aging theory. Cell. 144: 11-2. PMID 21215364 DOI: 10.1016/J.Cell.2010.12.023 |
0.51 |
|
| 2010 |
Lee HY, Choi CS, Birkenfeld AL, Alves TC, Jornayvaz FR, Jurczak MJ, Zhang D, Woo DK, Shadel GS, Ladiges W, Rabinovitch PS, Santos JH, Petersen KF, Samuel VT, Shulman GI. Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metabolism. 12: 668-74. PMID 21109199 DOI: 10.1016/J.Cmet.2010.11.004 |
0.555 |
|
| 2010 |
Chatenay-Lapointe M, Shadel GS. Stressed-out mitochondria get MAD. Cell Metabolism. 12: 559-60. PMID 21109188 DOI: 10.1016/J.Cmet.2010.11.018 |
0.547 |
|
| 2010 |
Shutt TE, Lodeiro MF, Cotney J, Cameron CE, Shadel GS. Core human mitochondrial transcription apparatus is a regulated two-component system in vitro. Proceedings of the National Academy of Sciences of the United States of America. 107: 12133-8. PMID 20562347 DOI: 10.1073/Pnas.0910581107 |
0.795 |
|
| 2010 |
Shutt TE, Shadel GS. A compendium of human mitochondrial gene expression machinery with links to disease. Environmental and Molecular Mutagenesis. 51: 360-79. PMID 20544879 DOI: 10.1002/Em.20571 |
0.688 |
|
| 2009 |
Pan Y, Shadel GS. Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density. Aging. 1: 131-45. PMID 20157595 |
0.564 |
|
| 2009 |
Raimundo N, Shadel GS. A "radical" mitochondrial view of autophagy-related pathology. Aging. 1: 354-6. PMID 20157522 |
0.475 |
|
| 2009 |
Shadel GS, Pan Y. Multi-faceted regulation of mitochondria by TOR. Cell Cycle (Georgetown, Tex.). 8: 2143. PMID 19587547 DOI: 10.4161/Cc.8.14.9117 |
0.571 |
|
| 2009 |
Pawar V, Jingjing L, Patel N, Kaur N, Doetsch PW, Shadel GS, Zhang H, Siede W. Checkpoint kinase phosphorylation in response to endogenous oxidative DNA damage in repair-deficient stationary-phase Saccharomyces cerevisiae. Mechanisms of Ageing and Development. 130: 501-8. PMID 19540258 DOI: 10.1016/J.Mad.2009.06.002 |
0.393 |
|
| 2009 |
Griffiths LM, Doudican NA, Shadel GS, Doetsch PW. Mitochondrial DNA oxidative damage and mutagenesis in Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 554: 267-86. PMID 19513680 DOI: 10.1007/978-1-59745-521-3_17 |
0.544 |
|
| 2009 |
Suissa S, Wang Z, Poole J, Wittkopp S, Feder J, Shutt TE, Wallace DC, Shadel GS, Mishmar D. Ancient mtDNA genetic variants modulate mtDNA transcription and replication Plos Genetics. 5. PMID 19424428 DOI: 10.1371/Journal.Pgen.1000474 |
0.555 |
|
| 2009 |
Cotney J, McKay SE, Shadel GS. Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness. Human Molecular Genetics. 18: 2670-82. PMID 19417006 DOI: 10.1093/Hmg/Ddp208 |
0.828 |
|
| 2009 |
Lebedeva MA, Eaton JS, Shadel GS. Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis. Biochimica Et Biophysica Acta. 1787: 328-34. PMID 19413947 DOI: 10.1016/J.Bbabio.2009.01.004 |
0.657 |
|
| 2009 |
Crouser ED, Shao G, Julian MW, Macre JE, Shadel GS, Tridandapani S, Huang Q, Wewers MD. Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors. Critical Care Medicine. 37: 2000-9. PMID 19384205 DOI: 10.1097/Ccm.0B013E3181A001Ae |
0.463 |
|
| 2009 |
Tal MC, Sasai M, Lee HK, Yordy B, Shadel GS, Iwasaki A. Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proceedings of the National Academy of Sciences of the United States of America. 106: 2770-5. PMID 19196953 DOI: 10.1073/Pnas.0807694106 |
0.499 |
|
| 2008 |
Shadel GS. Into the wild frontier of mitochondrial disease and aging. Methods (San Diego, Calif.). 46: 239-40. PMID 19027636 DOI: 10.1016/J.Ymeth.2008.10.027 |
0.539 |
|
| 2008 |
Bonawitz ND, Chatenay-Lapointe M, Wearn CM, Shadel GS. Expression of the rDNA-encoded mitochondrial protein Tar1p is stringently controlled and responds differentially to mitochondrial respiratory demand and dysfunction. Current Genetics. 54: 83-94. PMID 18622616 DOI: 10.1007/S00294-008-0203-0 |
0.85 |
|
| 2008 |
Shadel GS. Expression and maintenance of mitochondrial DNA: new insights into human disease pathology. The American Journal of Pathology. 172: 1445-56. PMID 18458094 DOI: 10.2353/Ajpath.2008.071163 |
0.696 |
|
| 2008 |
Schleicher M, Shepherd BR, Suarez Y, Fernandez-Hernando C, Yu J, Pan Y, Acevedo LM, Shadel GS, Sessa WC. Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. The Journal of Cell Biology. 180: 101-12. PMID 18195103 DOI: 10.1083/Jcb.200706072 |
0.54 |
|
| 2007 |
D'Souza AD, Parikh N, Kaech SM, Shadel GS. Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation. Mitochondrion. 7: 374-85. PMID 17890163 DOI: 10.1016/J.Mito.2007.08.001 |
0.641 |
|
| 2007 |
Eaton JS, Lin ZP, Sartorelli AC, Bonawitz ND, Shadel GS. Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. The Journal of Clinical Investigation. 117: 2723-34. PMID 17786248 DOI: 10.1172/Jci31604 |
0.835 |
|
| 2007 |
Lebedeva MA, Shadel GS. Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression. Cell Cycle (Georgetown, Tex.). 6: 2048-57. PMID 17721079 DOI: 10.4161/Cc.6.16.4572 |
0.655 |
|
| 2007 |
Bonawitz ND, Shadel GS. Rethinking the mitochondrial theory of aging: the role of mitochondrial gene expression in lifespan determination. Cell Cycle (Georgetown, Tex.). 6: 1574-8. PMID 17603300 DOI: 10.4161/Cc.6.13.4457 |
0.83 |
|
| 2007 |
Cotney J, Wang Z, Shadel GS. Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression. Nucleic Acids Research. 35: 4042-54. PMID 17557812 DOI: 10.1093/Nar/Gkm424 |
0.787 |
|
| 2007 |
Shadel GS, Seidel-Rogol BL. Diagnostic assays for defects in mtDNA replication and transcription in yeast and humans. Methods in Cell Biology. 80: 465-79. PMID 17445709 DOI: 10.1016/S0091-679X(06)80023-3 |
0.633 |
|
| 2007 |
Bonawitz ND, Chatenay-Lapointe M, Pan Y, Shadel GS. Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metabolism. 5: 265-77. PMID 17403371 DOI: 10.1016/J.Cmet.2007.02.009 |
0.809 |
|
| 2007 |
Wang Z, Cotney J, Shadel GS. Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression. The Journal of Biological Chemistry. 282: 12610-8. PMID 17337445 DOI: 10.1074/Jbc.M700461200 |
0.826 |
|
| 2007 |
Zhang H, Luo Y, Zhang W, He Y, Dai S, Zhang R, Huang Y, Bernatchez P, Giordano FJ, Shadel G, Sessa WC, Min W. Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. The American Journal of Pathology. 170: 1108-20. PMID 17322393 DOI: 10.2353/Ajpath.2007.060960 |
0.446 |
|
| 2007 |
Shutt TE, Shadel GS. Expanding the mitochondrial interactome. Genome Biology. 8: 203. PMID 17319976 DOI: 10.1186/Gb-2007-8-2-203 |
0.596 |
|
| 2007 |
Lin ZP, Belcourt MF, Carbone R, Eaton JS, Penketh PG, Shadel GS, Cory JG, Sartorelli AC. Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress. Biochemical Pharmacology. 73: 760-72. PMID 17188250 DOI: 10.1016/J.Bcp.2006.11.014 |
0.313 |
|
| 2006 |
Bonawitz ND, Clayton DA, Shadel GS. Initiation and beyond: multiple functions of the human mitochondrial transcription machinery. Molecular Cell. 24: 813-25. PMID 17189185 DOI: 10.1016/J.Molcel.2006.11.024 |
0.839 |
|
| 2006 |
Cotney J, Shadel GS. Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2. Journal of Molecular Evolution. 63: 707-17. PMID 17031457 DOI: 10.1007/S00239-006-0075-1 |
0.796 |
|
| 2006 |
Bonawitz ND, Rodeheffer MS, Shadel GS. Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span. Molecular and Cellular Biology. 26: 4818-29. PMID 16782871 DOI: 10.1128/Mcb.02360-05 |
0.838 |
|
| 2005 |
Shadel GS. Mitochondrial DNA, aconitase 'wraps' it up. Trends in Biochemical Sciences. 30: 294-6. PMID 15950872 DOI: 10.1016/J.Tibs.2005.04.007 |
0.661 |
|
| 2005 |
Doudican NA, Song B, Shadel GS, Doetsch PW. Oxidative DNA damage causes mitochondrial genomic instability in Saccharomyces cerevisiae. Molecular and Cellular Biology. 25: 5196-204. PMID 15923634 DOI: 10.1128/Mcb.25.12.5196-5204.2005 |
0.59 |
|
| 2005 |
O'Rourke TW, Doudican NA, Zhang H, Eaton JS, Doetsch PW, Shadel GS. Differential involvement of the related DNA helicases Pif1p and Rrm3p in mtDNA point mutagenesis and stability. Gene. 354: 86-92. PMID 15907372 DOI: 10.1016/J.Gene.2005.03.031 |
0.575 |
|
| 2005 |
Taylor SD, Zhang H, Eaton JS, Rodeheffer MS, Lebedeva MA, O'rourke TW, Siede W, Shadel GS. The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae. Molecular Biology of the Cell. 16: 3010-8. PMID 15829566 DOI: 10.1091/Mbc.E05-01-0053 |
0.785 |
|
| 2004 |
Shadel GS. Coupling the mitochondrial transcription machinery to human disease. Trends in Genetics : Tig. 20: 513-9. PMID 15363906 DOI: 10.1016/J.Tig.2004.08.005 |
0.665 |
|
| 2004 |
Shadel GS. A dual-function mitochondrial transcription factor tunes out deafness. Molecular Genetics and Metabolism. 82: 1-3. PMID 15110315 DOI: 10.1016/J.Ymgme.2004.02.003 |
0.617 |
|
| 2003 |
McCulloch V, Shadel GS. Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. Molecular and Cellular Biology. 23: 5816-24. PMID 12897151 DOI: 10.1128/Mcb.23.16.5816-5824.2003 |
0.534 |
|
| 2003 |
Rodeheffer MS, Shadel GS. Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis. The Journal of Biological Chemistry. 278: 18695-701. PMID 12637560 DOI: 10.1074/Jbc.M301399200 |
0.829 |
|
| 2003 |
Seidel-Rogol BL, McCulloch V, Shadel GS. Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. Nature Genetics. 33: 23-4. PMID 12496758 DOI: 10.1038/Ng1064 |
0.556 |
|
| 2002 |
Coelho PS, Bryan AC, Kumar A, Shadel GS, Snyder M. A novel mitochondrial protein, Tar1p, is encoded on the antisense strand of the nuclear 25S rDNA. Genes & Development. 16: 2755-60. PMID 12414727 DOI: 10.1101/Gad.1035002 |
0.571 |
|
| 2002 |
O'Rourke TW, Doudican NA, Mackereth MD, Doetsch PW, Shadel GS. Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins. Molecular and Cellular Biology. 22: 4086-93. PMID 12024022 DOI: 10.1128/Mcb.22.12.4086-4093.2002 |
0.613 |
|
| 2002 |
Seidel-Rogol BL, Shadel GS. Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells. Nucleic Acids Research. 30: 1929-34. PMID 11972329 DOI: 10.1093/Nar/30.9.1929 |
0.669 |
|
| 2002 |
McCulloch V, Seidel-Rogol BL, Shadel GS. A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. Molecular and Cellular Biology. 22: 1116-25. PMID 11809803 DOI: 10.1128/Mcb.22.4.1116-1125.2002 |
0.639 |
|
| 2002 |
Bryan AC, Rodeheffer MS, Wearn CM, Shadel GS. Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression. Genetics. 160: 75-82. PMID 11805046 |
0.751 |
|
| 2001 |
Seidel-Rogol BL, Shadel GS. Diagnostic assays for defects in mitochondrial DNA replication and transcription in yeast and human cells Methods in Cell Biology. 413-427. PMID 11381607 DOI: 10.1016/S0091-679X(01)65024-6 |
0.631 |
|
| 2001 |
Rodeheffer MS, Boone BE, Bryan AC, Shadel GS. Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. The Journal of Biological Chemistry. 276: 8616-22. PMID 11118450 DOI: 10.1074/Jbc.M009901200 |
0.751 |
|
| 2000 |
Shadel GS, Buckenmeyer GA, Clayton DA, Schmitt ME. Mutational analysis of the RNA component of Saccharomyces cerevisiae RNase MRP reveals distinct nuclear phenotypes Gene. 245: 175-184. PMID 10713458 DOI: 10.1016/S0378-1119(00)00013-5 |
0.36 |
|
| 1999 |
Shadel GS. Yeast as a model for human mtDNA replication American Journal of Human Genetics. 65: 1230-1237. PMID 10521287 DOI: 10.1086/302630 |
0.651 |
|
| 1999 |
Wang Y, Shadel GS. Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase Proceedings of the National Academy of Sciences of the United States of America. 96: 8046-8051. PMID 10393945 DOI: 10.1073/Pnas.96.14.8046 |
0.624 |
|
| 1997 |
Shadel GS, Clayton DA. Mitochondrial DNA maintenance in vertebrates Annual Review of Biochemistry. 66: 409-436. PMID 9242913 DOI: 10.1146/Annurev.Biochem.66.1.409 |
0.54 |
|
| 1996 |
Carrodeguas JA, Yun S, Shadel GS, Clayton DA, Bogenhagen DF. Functional conservation of yeast mtTFB despite extensive sequence divergence. Gene Expression. 6: 219-30. PMID 9196077 |
0.323 |
|
| 1996 |
Shadel GS, Clayton DA. [14] Isolation and characterization of vertebrate mitochondrial transcription factor A homologs Methods in Enzymology. 264: 149-157. PMID 8965689 DOI: 10.1016/S0076-6879(96)64016-6 |
0.591 |
|
| 1996 |
Shadel GS, Clayton DA. [13] Mapping promoters in displacement-loop region of vertebrate mitochondrial DNA Methods in Enzymology. 264: 139-148. PMID 8965688 DOI: 10.1016/S0076-6879(96)64015-4 |
0.554 |
|
| 1996 |
Sitnikov DM, Shadel GS, Baldwin TO. Autoinducer-independent mutants of the LuxR transcriptional activator exhibit differential effects on the two lux promoters of Vibrio fischeri Molecular and General Genetics. 252: 622-625. PMID 8914523 DOI: 10.1007/Bf02172408 |
0.391 |
|
| 1995 |
Shadel GS, Clayton DA. A Saccharomyces cerevisiae mitochondrial transcription factor, sc-mtTFB, shares features with sigma factors but is functionally distinct Molecular and Cellular Biology. 15: 2101-2108. PMID 7891705 DOI: 10.1128/Mcb.15.4.2101 |
0.48 |
|
| 1995 |
Dairaghi DJ, Shadel GS, Clayton DA. Addition of a 29 Residue Carboxyl-terminal Tail Converts a Simple HMG Box-containing Protein into a Transcriptional Activator Journal of Molecular Biology. 249: 11-28. PMID 7776365 DOI: 10.1006/Jmbi.1995.9889 |
0.537 |
|
| 1995 |
Dairaghi DJ, Shadel GS, Clayton DA. Human mitochondrial transcription factor A and promoter spacing integrity are required for transcription initiation Bba - Molecular Basis of Disease. 1271: 127-134. PMID 7599198 DOI: 10.1016/0925-4439(95)00019-Z |
0.495 |
|
| 1995 |
Dairaghi DJ, Shadel GS, Clayton DA. The Alternatively Spliced Form of Human Mitochondrial Transcription Factor a Displays Altered DNA Binding Properties Progress in Cell Research. 5: 137-141. DOI: 10.1016/B978-0-444-82235-2.50027-8 |
0.531 |
|
| 1993 |
Shadel GS, Clayton DA. Mitochondrial transcription initiation. Variation and conservation Journal of Biological Chemistry. 268: 16083-16086. PMID 8344889 |
0.525 |
|
| 1990 |
Shadel GS, Devine JH, Baldwin TO. Control of the lux regulon of Vibrio fischeri Journal of Bioluminescence and Chemiluminescence. 5: 99-106. PMID 2186599 DOI: 10.1002/Bio.1170050205 |
0.378 |
|
| 1990 |
Shadel GS, Young R, Baldwin TO. Use of regulated cell lysis in a lethal genetic selection in Escherichia coli: Identification of the autoinducer-binding region of the LuxR protein from Vibrio fischeri ATCC 7744 Journal of Bacteriology. 172: 3980-3987. PMID 2141835 DOI: 10.1128/Jb.172.7.3980-3987.1990 |
0.332 |
|
| 1989 |
Baldwin TO, Devine JH, Heckel RC, Lin JW, Shadel GS. The complete nucleotide sequence of the lux regulon of Vibrio fischeri and the luxABN region of Photobacterium leiognathi and the mechanism of control of bacterial bioluminescence Journal of Bioluminescence and Chemiluminescence. 4: 326-341. PMID 2801220 DOI: 10.1002/Bio.1170040145 |
0.329 |
|
| 1989 |
Devine JH, Shadel GS, Baldwin TO. Identification of the operator of the lux regulon from the Vibrio fischeri strain ATCC7744 Proceedings of the National Academy of Sciences of the United States of America. 86: 5688-5692. PMID 2762291 DOI: 10.1073/Pnas.86.15.5688 |
0.364 |
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