| Year |
Citation |
Score |
| 2025 |
Bélanger K, Wu C, Sulea T, van Faassen H, Callaghan D, Aubry A, Sasseville M, Hussack G, Tanha J. Optimization of synthetic human V affinity and solubility through in vitro affinity maturation and minimal camelization. Protein Science : a Publication of the Protein Society. 34: e70114. PMID 40260965 DOI: 10.1002/pro.70114 |
0.678 |
|
| 2025 |
Li W, Mandel U, van Faassen H, Parker MJ, Legg MSG, Hussack G, Clausen H, Evans SV. Structure of the Fab fragment of a humanized 5E5 antibody to a cancer-specific Tn-MUC1 epitope. Acta Crystallographica. Section D, Structural Biology. PMID 40221891 DOI: 10.1107/S2059798325002554 |
0.341 |
|
| 2024 |
Henry KA, Hussack G, Gettemans J, Brooks CL. Editorial: Single-domain antibodies-biology, engineering and emerging applications, volume II. Frontiers in Immunology. 15: 1537054. PMID 39742268 DOI: 10.3389/fimmu.2024.1537054 |
0.335 |
|
| 2024 |
Martina M, Banderali U, Yogi A, Arbabi Ghahroudi M, Liu H, Sulea T, Durocher Y, Hussack G, van Faassen H, Chakravarty B, Liu QY, Iqbal U, Ling B, Lessard E, Sheff J, et al. A Novel Antigen Design Strategy to Isolate Single-Domain Antibodies that Target Human Nav1.7 and Reduce Pain in Animal Models. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2405432. PMID 39206821 DOI: 10.1002/advs.202405432 |
0.365 |
|
| 2024 |
Lei EK, Azmat A, Henry KA, Hussack G. Outer membrane vesicles as a platform for the discovery of antibodies to bacterial pathogens. Applied Microbiology and Biotechnology. 108: 232. PMID 38396192 DOI: 10.1007/s00253-024-13033-5 |
0.335 |
|
| 2024 |
Aguilar EN, Sagar S, Murray BR, Rajesh C, Lei EK, Michaud SA, Goodlett DR, Caffrey TC, Grandgenett PM, Swanson B, Brooks TM, Black AR, van Faassen H, Hussack G, Henry KA, et al. Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6. Molecular Cancer Therapeutics. PMID 38394685 DOI: 10.1158/1535-7163.MCT-23-0868 |
0.48 |
|
| 2023 |
Kim DY, Kandalaft H, Lowden MJ, Yang Q, Rossotti MA, Robotham A, Kelly JF, Hussack G, Schrag JD, Henry KA, Tanha J. Sequence tolerance of immunoglobulin variable domain framework regions to non-canonical intradomain disulfide linkages. The Journal of Biological Chemistry. 105278. PMID 37742917 DOI: 10.1016/j.jbc.2023.105278 |
0.66 |
|
| 2023 |
Lowden MJ, Lei EK, Hussack G, Henry KA. Applications of High-Throughput DNA Sequencing to Single-Domain Antibody Discovery and Engineering. Methods in Molecular Biology (Clifton, N.J.). 2702: 489-540. PMID 37679637 DOI: 10.1007/978-1-0716-3381-6_26 |
0.431 |
|
| 2023 |
Rossotti MA, Trempe F, van Faassen H, Hussack G, Arbabi-Ghahroudi M. Isolation and Characterization of Single-Domain Antibodies from Immune Phage Display Libraries. Methods in Molecular Biology (Clifton, N.J.). 2702: 107-147. PMID 37679618 DOI: 10.1007/978-1-0716-3381-6_7 |
0.449 |
|
| 2023 |
Lei EK, Ryan S, van Faassen H, Foss M, Robotham A, Baltat I, Fulton K, Henry KA, Chen W, Hussack G. Isolation and characterization of a VHH targeting the Acinetobacter baumannii cell surface protein CsuA/B. Applied Microbiology and Biotechnology. 1-14. PMID 37284893 DOI: 10.1007/s00253-023-12594-1 |
0.362 |
|
| 2023 |
Hussack G, Rossotti MA, van Faassen H, Murase T, Eugenio L, Schrag JD, Ng KK, Tanha J. Corrigendum: Structure-guided design of a potent toxin A inhibitor. Frontiers in Microbiology. 14: 1167817. PMID 37065148 DOI: 10.3389/fmicb.2023.1167817 |
0.517 |
|
| 2023 |
Hussack G, Rossotti MA, van Faassen H, Murase T, Eugenio L, Schrag JD, Ng KK, Tanha J. Structure-guided design of a potent toxin A inhibitor. Frontiers in Microbiology. 14: 1110541. PMID 36778856 DOI: 10.3389/fmicb.2023.1110541 |
0.566 |
|
| 2022 |
Sheff J, Kelly J, Foss M, Brunette E, Kemmerich K, van Faassen H, Raphael S, Hussack G, Comamala G, Rand K, Stanimirovic DB. Epitope mapping of a blood-brain barrier crossing antibody targeting the cysteine-rich region of IGF1R using hydrogen-exchange mass spectrometry enabled by electrochemical reduction. Journal of Biochemistry. PMID 36346120 DOI: 10.1093/jb/mvac088 |
0.376 |
|
| 2022 |
Rossotti MA, van Faassen H, Tran AT, Sheff J, Sandhu JK, Duque D, Hewitt M, Wen X, Bavananthasivam J, Beitari S, Matte K, Laroche G, Giguère PM, Gervais C, Stuible M, ... ... Hussack G, et al. Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models. Communications Biology. 5: 933. PMID 36085335 DOI: 10.1038/s42003-022-03866-z |
0.697 |
|
| 2022 |
Yogi A, Hussack G, van Faassen H, Haqqani AS, Delaney CE, Brunette E, Sandhu JK, Hewitt M, Sulea T, Kemmerich K, Stanimirovic DB. Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor. Pharmaceutics. 14. PMID 35890347 DOI: 10.3390/pharmaceutics14071452 |
0.337 |
|
| 2022 |
Cairns CM, Michael FS, Jamshidi M, van Faassen H, Yang Q, Henry KA, Hussack G, Sauvageau J, Vinogradov EV, Cox AD. Structural Characterization and Evaluation of an Epitope at the Tip of the A-Band Rhamnan Polysaccharide of . Acs Infectious Diseases. PMID 35653593 DOI: 10.1021/acsinfecdis.2c00183 |
0.386 |
|
| 2022 |
Lowden MJ, van Faassen H, Raphael S, Ryan S, Hussack G, Henry KA. Facile Affinity Maturation of Single-Domain Antibodies Using Next-Generation DNA Sequencing. Methods in Molecular Biology (Clifton, N.J.). 2446: 245-268. PMID 35157277 DOI: 10.1007/978-1-0716-2075-5_12 |
0.434 |
|
| 2021 |
Henry KA, Nguyen TD, Baral TN, Hussack G, Raphael S, Arbabi-Ghahroudi M, Robert A, Durocher Y, Wu C, Jaramillo ML, MacKenzie CR. Biparatopic single-domain antibodies against Axl achieve ultra-high affinity through intramolecular engagement. Biochemical and Biophysical Research Communications. 562: 154-161. PMID 34058562 DOI: 10.1016/j.bbrc.2021.05.030 |
0.49 |
|
| 2021 |
van Faassen H, Jo DH, Ryan S, Lowden MJ, Raphael S, MacKenzie CR, Lee SH, Hussack G, Henry KA. Incorporation of a Novel CD16-Specific Single-Domain Antibody into Multispecific Natural Killer Cell Engagers With Potent ADCC. Molecular Pharmaceutics. PMID 33999642 DOI: 10.1021/acs.molpharmaceut.1c00208 |
0.303 |
|
| 2020 |
van Faassen H, Ryan S, Henry KA, Raphael S, Yang Q, Rossotti MA, Brunette E, Jiang S, Haqqani AS, Sulea T, MacKenzie CR, Tanha J, Hussack G. Serum albumin-binding V Hs with variable pH sensitivities enable tailored half-life extension of biologics. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32342547 DOI: 10.1096/Fj.201903231R |
0.664 |
|
| 2020 |
Cairns CM, van Faassen H, St Michael F, Aubry A, Henry KA, Rossotti MA, Logan SM, Hussack G, Gisch N, Hogendorf WF, Pedersen CM, Cox AD. Development and characterisation of mouse monoclonal antibodies specific for Clostridiodes (Clostridium) difficile lipoteichoic acid. Acs Chemical Biology. PMID 32191024 DOI: 10.1021/Acschembio.0C00066 |
0.555 |
|
| 2020 |
Richard G, MacKenzie CR, Henry KA, Vinogradov E, Hall JC, Hussack G. Antibody Binding to the O-Specific Antigen of O6 Inhibits Cell Growth. Antimicrobial Agents and Chemotherapy. PMID 32015038 DOI: 10.1128/AAC.02168-19 |
0.378 |
|
| 2019 |
Henry KA, Hussack G, Kumaran J, Gilbert M, MacKenzie CR, Sulea T, Arbabi-Ghahroudi M. Role of the non-hypervariable FR3 D-E loop in single-domain antibody recognition of haptens and carbohydrates. Journal of Molecular Recognition : Jmr. e2805. PMID 31423671 DOI: 10.1002/Jmr.2805 |
0.579 |
|
| 2019 |
Togtema M, Hussack G, Dayer G, Teghtmeyer MR, Raphael S, Tanha J, Zehbe I. Single-Domain Antibodies Represent Novel Alternatives to Monoclonal Antibodies as Targeting Agents against the Human Papillomavirus 16 E6 Protein. International Journal of Molecular Sciences. 20. PMID 31035322 DOI: 10.3390/Ijms20092088 |
0.709 |
|
| 2019 |
Kim DY, Kandalaft H, Hussack G, Raphael S, Ding W, Kelly JF, Henry KA, Tanha J. Evaluation of a non-canonical Cys40-Cys55 disulfide linkage for stabilization of single-domain antibodies. Protein Science : a Publication of the Protein Society. PMID 30803088 DOI: 10.1002/Pro.3595 |
0.713 |
|
| 2019 |
D'Eall C, Pon RA, Rossotti MA, Krahn N, Spearman M, Callaghan D, van Faassen H, Hussack G, Stetefeld J, Butler M, Durocher Y, Zhang J, Henry KA, Tanha J. Modulation of antibody-dependent cellular cytotoxicity of EGFR-specific heavy-chain antibodies through hinge engineering. Immunology and Cell Biology. PMID 30680791 DOI: 10.1111/Imcb.12238 |
0.736 |
|
| 2019 |
Rossotti MA, Henry KA, van Faassen H, Tanha J, Callaghan D, Hussack G, Arbabi-Ghahroudi M, MacKenzie CR. Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling. The Biochemical Journal. 476: 39-50. PMID 30455372 DOI: 10.1042/Bcj20180795 |
0.688 |
|
| 2018 |
Hussack G, Ryan S, van Faassen H, Rossotti M, MacKenzie CR, Tanha J. Neutralization of Clostridium difficile toxin B with VHH-Fc fusions targeting the delivery and CROPs domains. Plos One. 13: e0208978. PMID 30540857 DOI: 10.1371/Journal.Pone.0208978 |
0.708 |
|
| 2018 |
Hussack G, Raphael S, Lowden MJ, Henry KA. Isolation and characterization of camelid single-domain antibodies against HER2. Bmc Research Notes. 11: 866. PMID 30518413 DOI: 10.1186/S13104-018-3955-8 |
0.55 |
|
| 2018 |
Sulea T, Hussack G, Ryan S, Tanha J, Purisima EO. Application of Assisted Design of Antibody and Protein Therapeutics (ADAPT) improves efficacy of a Clostridium difficile toxin A single-domain antibody. Scientific Reports. 8: 2260. PMID 29396522 DOI: 10.1038/S41598-018-20599-4 |
0.728 |
|
| 2017 |
Henry KA, Kim DY, Kandalaft H, Lowden MJ, Yang Q, Schrag JD, Hussack G, MacKenzie CR, Tanha J. Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human VH/VL Single-Domain Antibodies from In Vitro Display Libraries. Frontiers in Immunology. 8: 1759. PMID 29375542 DOI: 10.3389/Fimmu.2017.01759 |
0.731 |
|
| 2017 |
Hussack G, Baral TN, Baardsnes J, van Faassen H, Raphael S, Henry KA, Zhang J, MacKenzie CR. A Novel Affinity Tag, ABTAG, and Its Application to the Affinity Screening of Single-Domain Antibodies Selected by Phage Display. Frontiers in Immunology. 8: 1406. PMID 29163485 DOI: 10.3389/Fimmu.2017.01406 |
0.508 |
|
| 2017 |
Henry KA, Kandalaft H, Lowden MJ, Rossotti MA, van Faassen H, Hussack G, Durocher Y, Kim DY, Tanha J. A disulfide-stabilized human VL single-domain antibody library is a source of soluble and highly thermostable binders. Molecular Immunology. 90: 190-196. PMID 28820969 DOI: 10.1016/J.Molimm.2017.07.006 |
0.746 |
|
| 2016 |
Henry KA, Sulea T, van Faassen H, Hussack G, Purisima EO, MacKenzie CR, Arbabi-Ghahroudi M. A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies. Plos One. 11: e0163113. PMID 27631624 DOI: 10.1371/Journal.Pone.0163113 |
0.529 |
|
| 2016 |
Henry KA, Hussack G, Collins C, Zwaagstra JC, Tanha J, MacKenzie CR. Isolation of TGF-β-neutralizing single-domain antibodies of predetermined epitope specificity using next-generation DNA sequencing. Protein Engineering, Design & Selection : Peds. PMID 27613412 DOI: 10.1093/Protein/Gzw043 |
0.679 |
|
| 2016 |
Hussack G, Tanha J. An update on antibody-based immunotherapies for Clostridium difficile infection. Clinical and Experimental Gastroenterology. 9: 209-24. PMID 27536153 DOI: 10.2147/Ceg.S84017 |
0.698 |
|
| 2015 |
Henry KA, Tanha J, Hussack G. Identification of cross-reactive single-domain antibodies against serum albumin using next-generation DNA sequencing. Protein Engineering, Design & Selection : Peds. 28: 379-83. PMID 26319004 DOI: 10.1093/Protein/Gzv039 |
0.701 |
|
| 2015 |
Kandalaft H, Hussack G, Aubry A, van Faassen H, Guan Y, Arbabi-Ghahroudi M, MacKenzie R, Logan SM, Tanha J. Targeting surface-layer proteins with single-domain antibodies: a potential therapeutic approach against Clostridium difficile-associated disease. Applied Microbiology and Biotechnology. PMID 25936376 DOI: 10.1007/S00253-015-6594-1 |
0.723 |
|
| 2014 |
Kim DY, Hussack G, Kandalaft H, Tanha J. Mutational approaches to improve the biophysical properties of human single-domain antibodies. Biochimica Et Biophysica Acta. 1844: 1983-2001. PMID 25065345 DOI: 10.1016/J.Bbapap.2014.07.008 |
0.737 |
|
| 2014 |
Hussack G, Riazi A, Ryan S, van Faassen H, MacKenzie R, Tanha J, Arbabi-Ghahroudi M. Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility. Protein Engineering, Design & Selection : Peds. 27: 191-8. PMID 24742504 DOI: 10.1093/Protein/Gzu011 |
0.694 |
|
| 2014 |
Murase T, Eugenio L, Schorr M, Hussack G, Tanha J, Kitova EN, Klassen JS, Ng KK. Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile. The Journal of Biological Chemistry. 289: 2331-43. PMID 24311789 DOI: 10.1074/Jbc.M113.505917 |
0.703 |
|
| 2012 |
Hussack G, Mackenzie CR, Tanha J. Characterization of single-domain antibodies with an engineered disulfide bond. Methods in Molecular Biology (Clifton, N.J.). 911: 417-29. PMID 22886266 DOI: 10.1007/978-1-61779-968-6_25 |
0.707 |
|
| 2012 |
Hussack G, Arbabi-Ghahroudi M, Mackenzie CR, Tanha J. Isolation and characterization of Clostridium difficile toxin-specific single-domain antibodies. Methods in Molecular Biology (Clifton, N.J.). 911: 211-39. PMID 22886255 DOI: 10.1007/978-1-61779-968-6_14 |
0.741 |
|
| 2012 |
Aubry A, Hussack G, Chen W, KuoLee R, Twine SM, Fulton KM, Foote S, Carrillo CD, Tanha J, Logan SM. Modulation of toxin production by the flagellar regulon in Clostridium difficile. Infection and Immunity. 80: 3521-32. PMID 22851750 DOI: 10.1128/Iai.00224-12 |
0.582 |
|
| 2012 |
Hussack G, Keklikian A, Alsughayyir J, Hanifi-Moghaddam P, Arbabi-Ghahroudi M, van Faassen H, Hou ST, Sad S, MacKenzie R, Tanha J. A V(L) single-domain antibody library shows a high-propensity to yield non-aggregating binders. Protein Engineering, Design & Selection : Peds. 25: 313-8. PMID 22490957 DOI: 10.1093/Protein/Gzs014 |
0.619 |
|
| 2012 |
Parisien A, Al-Zarka F, Hussack G, Baranova EA, Thibault J, Qingdao Lan C. Nickel nanoparticles synthesized by a modified polyol method for the purification of histidine-tagged single-domain antibody ToxA5.1 Journal of Materials Research. 27: 2884-2890. DOI: 10.1557/Jmr.2012.323 |
0.372 |
|
| 2011 |
Hussack G, Hirama T, Ding W, Mackenzie R, Tanha J. Engineered single-domain antibodies with high protease resistance and thermal stability. Plos One. 6: e28218. PMID 22140551 DOI: 10.1371/Journal.Pone.0028218 |
0.641 |
|
| 2011 |
Hussack G, Arbabi-Ghahroudi M, van Faassen H, Songer JG, Ng KK, MacKenzie R, Tanha J. Neutralization of Clostridium difficile toxin A with single-domain antibodies targeting the cell receptor binding domain. The Journal of Biological Chemistry. 286: 8961-76. PMID 21216961 DOI: 10.1074/Jbc.M110.198754 |
0.715 |
|
| 2010 |
Hussack G, Tanha J. Toxin-specific antibodies for the treatment of Clostridium difficile: current status and future perspectives. Toxins. 2: 998-1018. PMID 22069622 DOI: 10.3390/Toxins2050998 |
0.697 |
|
| 2010 |
Hussack G, Grohs BM, Almquist KC, McLean MD, Ghosh R, Hall JC. Purification of plant-derived antibodies through direct immobilization of affinity ligands on cellulose. Journal of Agricultural and Food Chemistry. 58: 3451-9. PMID 20170183 DOI: 10.1021/jf9040657 |
0.435 |
|
| 2009 |
Hussack G, Luo Y, Veldhuis L, Hall JC, Tanha J, Mackenzie R. Multivalent anchoring and oriented display of single-domain antibodies on cellulose. Sensors (Basel, Switzerland). 9: 5351-67. PMID 22346702 DOI: 10.3390/S90705351 |
0.735 |
|
| 2009 |
Doyle PJ, Saeed H, Hermans A, Gleddie SC, Hussack G, Arbabi-Ghahroudi M, Seguin C, Savard ME, Mackenzie CR, Hall JC. Intracellular expression of a single domain antibody reduces cytotoxicity of 15-acetyldeoxynivalenol in yeast. The Journal of Biological Chemistry. 284: 35029-39. PMID 19783651 DOI: 10.1074/Jbc.M109.045047 |
0.429 |
|
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