Christina Voelkel-Johnson - Publications

Affiliations: 
Medical University of South Carolina, Charleston, SC, United States 
Area:
Cell Biology, Molecular Biology

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 White-Gilbertson S, Lu P, Saatci O, Sahin O, Delaney JR, Ogretmen B, Voelkel-Johnson C. Transcriptome analysis of polyploid giant cancer cells and their progeny reveals a functional role for p21 in polyploidization and depolyploidization. The Journal of Biological Chemistry. 107136. PMID 38447798 DOI: 10.1016/j.jbc.2024.107136  0.328
2022 White-Gilbertson S, Lu P, Esobi I, Echesabal-Chen J, Mulholland PJ, Gooz M, Ogretmen B, Stamatikos A, Voelkel-Johnson C. Polyploid giant cancer cells are dependent on cholesterol for progeny formation through amitotic division. Scientific Reports. 12: 8971. PMID 35624221 DOI: 10.1038/s41598-022-12705-4  0.36
2022 Bowers RR, Andrade MF, Jones CM, White-Gilbertson S, Voelkel-Johnson C, Delaney JR. Autophagy modulating therapeutics inhibit ovarian cancer colony generation by polyploid giant cancer cells (PGCCs). Bmc Cancer. 22: 410. PMID 35421971 DOI: 10.1186/s12885-022-09503-6  0.361
2021 Lu P, White-Gilbertson S, Beeson G, Beeson C, Ogretmen B, Norris J, Voelkel-Johnson C. Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells. Cancers. 13. PMID 34062962 DOI: 10.3390/cancers13092212  0.374
2020 White-Gilbertson S, Voelkel-Johnson C. Giants and monsters: Unexpected characters in the story of cancer recurrence. Advances in Cancer Research. 148: 201-232. PMID 32723564 DOI: 10.1016/Bs.Acr.2020.03.001  0.424
2020 Burke B, Eden C, Perez C, Belshoff A, Hart S, Plaza-Rojas L, Delos Reyes M, Prajapati K, Voelkel-Johnson C, Henry E, Gupta G, Guevara-Patiño J. Inhibition of Histone Deacetylase (HDAC) Enhances Checkpoint Blockade Efficacy by Rendering Bladder Cancer Cells Visible for T Cell-Mediated Destruction. Frontiers in Oncology. 10: 699. PMID 32500025 DOI: 10.3389/Fonc.2020.00699  0.443
2020 White-Gilbertson S, Lu P, Jones CM, Chiodini S, Hurley D, Das A, Delaney JR, Norris JS, Voelkel-Johnson C. Tamoxifen is a candidate first-in-class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells-Unrecognized players in tumorigenesis. Cancer Medicine. PMID 32135040 DOI: 10.1002/cam4.2960  0.359
2019 Goklany S, Lu P, Godeshala S, Hall A, Garrett-Mayer E, Voelkel-Johnson C, Rege K. Delivery of TRAIL-expressing plasmid DNA to cancer cells in vitro and in vivo using aminoglycoside-derived polymers. Journal of Materials Chemistry. B. PMID 31633707 DOI: 10.1039/C9Tb01286A  0.503
2019 Angel PM, Saunders J, Clift CL, White-Gilbertson S, Voelkel-Johnson C, Yeh E, Mehta A, Drake RR. A Rapid Array-Based Approach to -Glycan Profiling of Cultured Cells. Journal of Proteome Research. PMID 31535553 DOI: 10.1021/Acs.Jproteome.9B00303  0.316
2019 White-Gilbertson S, Lu P, Norris JS, Voelkel-Johnson C. Genetic and pharmacological inhibition of acid ceramidase prevents asymmetric cell division by neosis. Journal of Lipid Research. PMID 30988134 DOI: 10.1194/Jlr.M092247  0.45
2019 Lu P, White-Gilbertson S, Nganga R, Kester M, Voelkel-Johnson C. Expression of the SNAI2 transcriptional repressor is regulated by C-ceramide. Cancer Biology & Therapy. 1-9. PMID 30836822 DOI: 10.1080/15384047.2019.1579962  0.446
2018 Nganga R, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Johnson KA, Parikh RY, Gangaraju V, Peterson Y, Dany M, Stahelin RV, Voelkel-Johnson C, Szulc ZM, Bieberich E, Ogretmen B. Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis. The Journal of Biological Chemistry. PMID 30420430 DOI: 10.1074/Jbc.Ra118.005865  0.34
2018 Johnson BM, Radwan FFY, Hossain A, Doonan BP, Hathaway-Schrader JD, God JM, Voelkel-Johnson CV, Banik NL, Reddy SV, Haque A. Endoplasmic reticulum stress, autophagic and apoptotic cell death, and immune activation by a natural triterpenoid in human prostate cancer cells. Journal of Cellular Biochemistry. PMID 30378157 DOI: 10.1002/Jcb.27913  0.334
2018 Lewis CS, Voelkel-Johnson C, Smith CD. Targeting Sphingosine Kinases for the Treatment of Cancer. Advances in Cancer Research. 140: 295-325. PMID 30060814 DOI: 10.1016/Bs.Acr.2018.04.015  0.339
2018 Voelkel-Johnson C, Norris JS, White-Gilbertson S. Interdiction of Sphingolipid Metabolism Revisited: Focus on Prostate Cancer. Advances in Cancer Research. 140: 265-293. PMID 30060812 DOI: 10.1016/Bs.Acr.2018.04.014  0.437
2018 Scheffel MJ, Scurti G, Wyatt MM, Garrett-Mayer E, Paulos CM, Nishimura MI, Voelkel-Johnson C. N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner. Cancer Immunology, Immunotherapy : Cii. PMID 29396710 DOI: 10.1007/S00262-018-2120-5  0.427
2018 Helke K, Angel P, Lu P, Garrett-Mayer E, Ogretmen B, Drake R, Voelkel-Johnson C. Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis. Scientific Reports. 8: 1627. PMID 29374263 DOI: 10.1038/S41598-018-20102-Z  0.313
2017 Scheffel MJ, Helke K, Lu P, Bowers JS, Ogretmen B, Garrett-Mayer E, Paulos CM, Voelkel-Johnson C. Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis. Scientific Reports. 7: 15552. PMID 29138469 DOI: 10.1038/S41598-017-15791-X  0.348
2017 Camp ER, Patterson LD, Kester M, Voelkel-Johnson C. Therapeutic Implications Of Bioactive Sphingolipids: A Focus On Colorectal Cancer. Cancer Biology & Therapy. 0. PMID 28686076 DOI: 10.1080/15384047.2017.1345396  0.388
2017 Sambandam Y, Reddy SV, Mulligan JL, Voelkel-Johnson C, Wagner CL. Vitamin D Modulation of TRAIL Expression in Human Milk and Mammary Epithelial Cells. Scientific Reports. 7: 4362. PMID 28659589 DOI: 10.1038/S41598-017-04521-Y  0.307
2016 Scheffel MJ, Scurti G, Simms P, Garrett-Mayer E, Mehrotra S, Nishimura MI, Voelkel-Johnson C. Efficacy of Adoptive T-cell Therapy Is Improved by Treatment with the Antioxidant N-Acetyl Cysteine, Which Limits Activation-Induced T-cell Death. Cancer Research. 76: 6006-6016. PMID 27742673 DOI: 10.1158/0008-5472.Can-16-0587  0.416
2016 Lewis CS, Voelkel-Johnson C, Smith CD. Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640. Oncotarget. PMID 27517489 DOI: 10.18632/Oncotarget.11112  0.469
2015 Venant H, Rahmaniyan M, Jones EE, Lu P, Lilly MB, Garrett-Mayer E, Drake RR, Kraveka JM, Smith CD, Voelkel-Johnson C. The sphingosine kinase 2 inhibitor ABC294640 reduces the growth of prostate cancer cells and results in accumulation of dihydroceramides in vitro and in vivo. Molecular Cancer Therapeutics. PMID 26494858 DOI: 10.1158/1535-7163.Mct-15-0279  0.442
2015 Tirodkar TS, Lu P, Bai A, Scheffel MJ, Gencer S, Garrett-Mayer E, Bielawska A, Ogretmen B, Voelkel-Johnson C. Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner. The Journal of Biological Chemistry. 290: 13157-67. PMID 25839235 DOI: 10.1074/Jbc.M114.631325  0.663
2015 Sundaram K, Sambandam Y, Balasubramanian S, Pillai B, Voelkel-Johnson C, Ries WL, Reddy SV. STAT-6 mediates TRAIL induced RANK ligand expression in stromal/preosteoblast cells. Bone. 71: 137-44. PMID 25445452 DOI: 10.1016/J.Bone.2014.10.016  0.446
2014 Kesarwani P, Al-Khami AA, Scurti G, Thyagarajan K, Kaur N, Husain S, Fang Q, Naga OS, Simms P, Beeson G, Voelkel-Johnson C, Garrett-Mayer E, Beeson CC, Nishimura MI, Mehrotra S. Promoting thiol expression increases the durability of antitumor T-cell functions. Cancer Research. 74: 6036-47. PMID 25164014 DOI: 10.1158/0008-5472.Can-14-1084  0.4
2014 Dai L, Plaisance-Bonstaff K, Voelkel-Johnson C, Smith CD, Ogretmen B, Qin Z, Parsons C. Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells. Plos One. 9: e102314. PMID 25010828 DOI: 10.1371/Journal.Pone.0102314  0.422
2014 Gosnell H, Kasman LM, Potta T, Vu L, Garrett-Mayer E, Rege K, Voelkel-Johnson C. Polymer-enhanced delivery increases adenoviral gene expression in an orthotopic model of bladder cancer. Journal of Controlled Release : Official Journal of the Controlled Release Society. 176: 35-43. PMID 24370892 DOI: 10.1016/J.Jconrel.2013.12.012  0.345
2014 Qin Z, Dai L, Trillo-Tinoco J, Senkal C, Wang W, Reske T, Bonstaff K, Del Valle L, Rodriguez P, Flemington E, Voelkel-Johnson C, Smith CD, Ogretmen B, Parsons C. Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. Molecular Cancer Therapeutics. 13: 154-64. PMID 24140934 DOI: 10.1158/1535-7163.Mct-13-0466  0.491
2013 Kasman L, Voelkel-Johnson C. An orthotopic bladder cancer model for gene delivery studies. Journal of Visualized Experiments : Jove. 50181. PMID 24326612 DOI: 10.3791/50181  0.368
2013 May LA, Kramarenko II, Brandon CS, Voelkel-Johnson C, Roy S, Truong K, Francis SP, Monzack EL, Lee FS, Cunningham LL. Inner ear supporting cells protect hair cells by secreting HSP70. The Journal of Clinical Investigation. 123: 3577-87. PMID 23863716 DOI: 10.1172/Jci68480  0.365
2013 Qin Z, Dai L, Plaisance-Bonstaff K, Senkal C, Wang W, Reske TM, Del Valle L, Voelkel-Johnson C, Flemington E, Ogretmen B, Smith CD, Parsons C. Targeting Sphingosine Kinase Induces Apoptosis and Regression Of Virus-Associated Lymphoma In Vivo Blood. 122: 4414-4414. DOI: 10.1182/Blood.V122.21.4414.4414  0.467
2012 Tirodkar TS, Voelkel-Johnson C. Sphingolipids in apoptosis. Experimental Oncology. 34: 231-42. PMID 23070008  0.686
2012 Brandon CS, Voelkel-Johnson C, May LA, Cunningham LL. Dissection of adult mouse utricle and adenovirus-mediated supporting-cell infection. Journal of Visualized Experiments : Jove. PMID 22491073 DOI: 10.3791/3734  0.372
2012 Kasman L, Onicescu G, Voelkel-Johnson C. Histone deacetylase inhibitors restore cell surface expression of the coxsackie adenovirus receptor and enhance CMV promoter activity in castration-resistant prostate cancer cells. Prostate Cancer. 2012: 137163. PMID 22288017 DOI: 10.1155/2012/137163  0.478
2011 Voelkel-Johnson C. TRAIL-mediated signaling in prostate, bladder and renal cancer. Nature Reviews. Urology. 8: 417-27. PMID 21670755 DOI: 10.1038/Nrurol.2011.81  0.509
2011 Murali A, Kasman L, Voelkel-Johnson C. Adenoviral infectivity of exfoliated viable cells in urine: implications for the detection of bladder cancer. Bmc Cancer. 11: 168. PMID 21569442 DOI: 10.1186/1471-2407-11-168  0.45
2010 Park MA, Reinehr R, Häussinger D, Voelkel-Johnson C, Ogretmen B, Yacoub A, Grant S, Dent P. Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells. Molecular Cancer Therapeutics. 9: 2220-31. PMID 20682655 DOI: 10.1158/1535-7163.Mct-10-0274  0.315
2010 Park MA, Mitchell C, Zhang G, Yacoub A, Allegood J, Häussinger D, Reinehr R, Larner A, Spiegel S, Fisher PB, Voelkel-Johnson C, Ogretmen B, Grant S, Dent P. Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. Cancer Research. 70: 6313-24. PMID 20631069 DOI: 10.1158/0008-5472.Can-10-0999  0.384
2010 Walker T, Mitchell C, Park MA, Yacoub A, Rahmani M, Häussinger D, Reinehr R, Voelkel-Johnson C, Fisher PB, Grant S, Dent P. 17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species. Molecular Cancer Therapeutics. 9: 1378-95. PMID 20442308 DOI: 10.1158/1535-7163.Mct-09-1131  0.404
2009 Kasman LM, Barua S, Lu P, Rege K, Voelkel-Johnson C. Polymer-enhanced adenoviral transduction of CAR-negative bladder cancer cells. Molecular Pharmaceutics. 6: 1612-9. PMID 19655763 DOI: 10.1021/Mp9000958  0.382
2009 Norell H, Martins da Palma T, Lesher A, Kaur N, Mehrotra M, Naga OS, Spivey N, Olafimihan S, Chakraborty NG, Voelkel-Johnson C, Nishimura MI, Mukherji B, Mehrotra S. Inhibition of superoxide generation upon T-cell receptor engagement rescues Mart-1(27-35)-reactive T cells from activation-induced cell death. Cancer Research. 69: 6282-9. PMID 19638595 DOI: 10.1158/0008-5472.Can-09-1176  0.492
2009 White-Gilbertson SJ, Kasman L, McKillop J, Tirodkar T, Lu P, Voelkel-Johnson C. Oxidative stress sensitizes bladder cancer cells to TRAIL mediated apoptosis by down-regulating anti-apoptotic proteins. The Journal of Urology. 182: 1178-85. PMID 19625063 DOI: 10.1016/J.Juro.2009.05.005  0.692
2009 White-Gilbertson S, Kurtz DT, Voelkel-Johnson C. The role of protein synthesis in cell cycling and cancer. Molecular Oncology. 3: 402-8. PMID 19546037 DOI: 10.1016/J.Molonc.2009.05.003  0.416
2009 Walker T, Mitchell C, Park MA, Yacoub A, Graf M, Rahmani M, Houghton PJ, Voelkel-Johnson C, Grant S, Dent P. Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. Molecular Pharmacology. 76: 342-55. PMID 19483104 DOI: 10.1124/Mol.109.056523  0.447
2009 Park MA, Walker T, Martin AP, Allegood J, Vozhilla N, Emdad L, Sarkar D, Rahmani M, Graf M, Yacoub A, Koumenis C, Spiegel S, Curiel DT, Voelkel-Johnson C, Grant S, et al. MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism. Molecular Cancer Therapeutics. 8: 1280-91. PMID 19417161 DOI: 10.1158/1535-7163.Mct-09-0073  0.423
2009 White-Gilbertson S, Mullen T, Senkal C, Lu P, Ogretmen B, Obeid L, Voelkel-Johnson C. Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells Oncogene. 28: 1132-1141. PMID 19137010 DOI: 10.1038/Onc.2008.468  0.552
2009 Voelkel-Johnson C. Combination therapy with TRAIL: Recent developments and potential pitfalls. Cancer Biology & Therapy. 8: 81-3. PMID 19127121 DOI: 10.4161/Cbt.8.1.7519  0.46
2008 White-Gilbertson S, Rubinchik S, Voelkel-Johnson C. Transformation, translation and TRAIL: an unexpected intersection. Cytokine & Growth Factor Reviews. 19: 167-72. PMID 18353705 DOI: 10.1016/J.Cytogfr.2008.01.007  0.497
2007 White SJ, Kasman LM, Kelly MM, Lu P, Spruill L, McDermott PJ, Voelkel-Johnson C. Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2. Free Radical Biology & Medicine. 43: 1313-21. PMID 17893044 DOI: 10.1016/J.Freeradbiomed.2007.06.015  0.484
2006 White SJ, Voelkel-Johnson C. Illuminating TRAIL gene therapy. Cancer Biology & Therapy. 5: 1521-2. PMID 17204862 DOI: 10.4161/Cbt.5.11.3691  0.517
2006 Kasman L, Lu P, Voelkel-Johnson C. The histone deacetylase inhibitors depsipeptide and MS-275, enhance TRAIL gene therapy of LNCaP prostate cancer cells without adverse effects in normal prostate epithelial cells. Cancer Gene Therapy. 14: 327-34. PMID 17186014 DOI: 10.1038/Sj.Cgt.7701017  0.464
2006 White SJ, Lu P, Keller GM, Voelkel-Johnson C. Targeting the short form of cFLIP by RNA interference is sufficient to enhance TRAIL sensitivity in PC3 prostate carcinoma cells. Cancer Biology & Therapy. 5: 1618-23. PMID 17106251 DOI: 10.4161/Cbt.5.12.3352  0.545
2006 Norris JS, Bielawska A, Day T, El-Zawahri A, ElOjeimy S, Hannun Y, Holman D, Hyer M, Landon C, Lowe S, Dong JY, McKillop J, Norris K, Obeid L, Rubinchik S, ... ... Voelkel-Johnson C, et al. Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report. Cancer Gene Therapy. 13: 1045-51. PMID 16763610 DOI: 10.1038/Sj.Cgt.7700965  0.411
2006 El-Zawahry A, Lu P, White SJ, Voelkel-Johnson C. In vitro efficacy of AdTRAIL gene therapy of bladder cancer is enhanced by trichostatin A-mediated restoration of CAR expression and downregulation of cFLIP and Bcl-XL. Cancer Gene Therapy. 13: 281-9. PMID 16167063 DOI: 10.1038/Sj.Cgt.7700905  0.523
2005 Voelkel-Johnson C, Hannun YA, El-Zawahry A. Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. Molecular Cancer Therapeutics. 4: 1320-7. PMID 16170023 DOI: 10.1158/1535-7163.Mct-05-0086  0.553
2005 El-Zawahry A, McKillop J, Voelkel-Johnson C. Doxorubicin increases the effectiveness of Apo2L/TRAIL for tumor growth inhibition of prostate cancer xenografts. Bmc Cancer. 5: 2. PMID 15638938 DOI: 10.1186/1471-2407-5-2  0.485
2005 Sudarshan S, Holman DH, Hyer ML, Voelkel-Johnson C, Dong JY, Norris JS. In vitro efficacy of Fas ligand gene therapy for the treatment of bladder cancer. Cancer Gene Therapy. 12: 12-8. PMID 15514684 DOI: 10.1038/Sj.Cgt.7700746  0.538
2005 El-Zawahry AM, Voelkel-Johnson C. 324. TRAIL Gene Therapy Is a Promising Therapy for Bladder Cancer Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.327  0.555
2003 Rubinchik S, Yu H, Woraratanadharm J, Voelkel-Johnson C, Norris JS, Dong JY. Enhanced apoptosis of glioma cell lines is achieved by co-delivering FasL-GFP and TRAIL with a complex Ad5 vector. Cancer Gene Therapy. 10: 814-22. PMID 14605667 DOI: 10.1038/Sj.Cgt.7700651  0.48
2003 Voelkel-Johnson C. An antibody against DR4 (TRAIL-R1) in combination with doxorubicin selectively kills malignant but not normal prostate cells. Cancer Biology & Therapy. 2: 283-90. PMID 12878867 DOI: 10.4161/Cbt.2.3.398  0.49
2002 Kelly MM, Hoel BD, Voelkel-Johnson C. Doxorubicin pretreatment sensitizes prostate cancer cell lines to TRAIL induced apoptosis which correlates with the loss of c-FLIP expression. Cancer Biology & Therapy. 1: 520-7. PMID 12496481 DOI: 10.4161/Cbt.1.5.169  0.546
2002 Voelkel-Johnson C, King DL, Norris JS. Resistance of prostate cancer cells to soluble TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) can be overcome by doxorubicin or adenoviral delivery of full-length TRAIL. Cancer Gene Therapy. 9: 164-72. PMID 11857034 DOI: 10.1038/Sj.Cgt.7700420  0.471
2000 Hyer ML, Voelkel-Johnson C, Rubinchik S, Dong J, Norris JS. Intracellular Fas ligand expression causes Fas-mediated apoptosis in human prostate cancer cells resistant to monoclonal antibody-induced apoptosis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 2: 348-58. PMID 11020350 DOI: 10.1006/Mthe.2000.0139  0.521
2000 Voelkel-Johnson C, Voeks DJ, Greenberg NM, Barrios R, Maggouta F, Kurtz DT, Schwartz DA, Keller GM, Papenbrock T, Clawson GA, Norris JS. Genomic instability-based transgenic models of prostate cancer Carcinogenesis. 21: 1623-1627. DOI: 10.1093/Carcin/21.5.623  0.312
1996 Thorne TE, Voelkel-Johnson C, Casey WM, Parks LW, Laster SM. The activity of cytosolic phospholipase A2 is required for the lysis of adenovirus-infected cells by tumor necrosis factor. Journal of Virology. 70: 8502-7. PMID 8970973 DOI: 10.1128/jvi.70.12.8502-8507.1996  0.344
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