| Year |
Citation |
Score |
| 2022 |
Soto PC, Terry VH, Lewinski MK, Deshmukh S, Beliakova-Bethell N, Spina CA. HIV-1 latency is established preferentially in minimally activated and non-dividing cells during productive infection of primary CD4 T cells. Plos One. 17: e0271674. PMID 35895672 DOI: 10.1371/journal.pone.0271674 |
0.554 |
|
| 2022 |
Beliakova-Bethell N, Manousopoulou A, Deshmukh S, Mukim A, Richman DD, Garbis SD, Spina CA. Integrated proteomics and transcriptomics analyses identify novel cell surface markers of HIV latency. Virology. 573: 50-58. PMID 35714458 DOI: 10.1016/j.virol.2022.06.003 |
0.525 |
|
| 2020 |
Heinson AI, Woo J, Mukim A, White CH, Moesker B, Bosque A, Spina C, Woelk CH, Macarthur BD, Beliakova-Bethell N. Micro RNA targets in HIV latency - insights into novel layers of latency control. Aids Research and Human Retroviruses. PMID 33045840 DOI: 10.1089/AID.2020.0150 |
0.333 |
|
| 2019 |
Trypsteen W, White CH, Mukim A, Spina CA, De Spiegelaere W, Lefever S, Planelles V, Bosque A, Woelk CH, Vandekerckhove L, Beliakova-Bethell N. Long non-coding RNAs and latent HIV - A search for novel targets for latency reversal. Plos One. 14: e0224879. PMID 31710657 DOI: 10.1371/Journal.Pone.0224879 |
0.592 |
|
| 2019 |
Christensen-Quick A, Massanella M, Frick A, Rawlings SA, Spina C, Vargas-Meneses M, Schrier R, Nakazawa M, Anderson C, Gianella S. Subclinical Cytomegalovirus DNA Is Associated with CD4 T Cell Activation and Impaired CD8 T Cell CD107a Expression in People Living with HIV despite Early Antiretroviral Therapy. Journal of Virology. PMID 31019052 DOI: 10.1128/Jvi.00179-19 |
0.67 |
|
| 2019 |
Beliakova-Bethell N, Mukim A, White CH, Deshmukh S, Abewe H, Richman DD, Spina CA. Histone deacetylase inhibitors induce complex host responses that contribute to differential potencies of these compounds in HIV reactivation. The Journal of Biological Chemistry. PMID 30745362 DOI: 10.1074/Jbc.Ra118.005185 |
0.581 |
|
| 2018 |
White CH, Beliakova-Bethell N, Lada SM, Breen MS, Hurst TP, Spina CA, Richman DD, Frater J, Magiorkinis G, Woelk CH. Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment. Frontiers in Immunology. 9: 603. PMID 29706951 DOI: 10.3389/Fimmu.2018.00603 |
0.563 |
|
| 2017 |
Beliakova-Bethell N, Hezareh M, Wong JK, Strain MC, Lewinski MK, Richman DD, Spina CA. Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART. Virology. 508: 127-133. PMID 28527342 DOI: 10.1016/J.Virol.2017.05.008 |
0.658 |
|
| 2017 |
Karris MY, Jain S, Day TR, Pérez-Santiago J, Goicoechea M, Dubé MP, Sun X, Spina C, Daar ES, Haubrich RH, Morris S. HIV viral kinetics and T cell dynamics in antiretroviral naïve persons starting an integrase strand transfer inhibitor and protease inhibitor regimen. Hiv Clinical Trials. 1-8. PMID 28134057 DOI: 10.1080/15284336.2017.1282578 |
0.522 |
|
| 2016 |
White CH, Moesker B, Beliakova-Bethell N, Martins LJ, Spina CA, Margolis DM, Richman DD, Planelles V, Bosque A, Woelk CH. Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model. Plos Pathogens. 12: e1006026. PMID 27898737 DOI: 10.1371/Journal.Ppat.1006026 |
0.646 |
|
| 2016 |
Dan JM, Massanella M, Smith DM, Spina CA, Schrier R, Daar ES, Dube MP, Morris SR, Gianella S. Effect of Cytomegalovirus and HIV Transcription on CD57 and PD-1 T cell expression during Suppressive ART. Journal of Acquired Immune Deficiency Syndromes (1999). PMID 26818740 DOI: 10.1097/Qai.0000000000000936 |
0.645 |
|
| 2015 |
Tokarev A, Stoneham C, Lewinski MK, Mukim A, Deshmukh S, Vollbrecht T, Spina CA, Guatelli J. Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-induced Epitopes within Env on Cells Expressing HIV-1. Journal of Virology. PMID 26676780 DOI: 10.1128/Jvi.02736-15 |
0.61 |
|
| 2015 |
White CH, Johnston HE, Moesker B, Manousopoulou A, Margolis DM, Richman DD, Spina CA, Garbis SD, Woelk CH, Beliakova-Bethell N. Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency. Antiviral Research. 123: 78-85. PMID 26343910 DOI: 10.1016/J.Antiviral.2015.09.002 |
0.535 |
|
| 2015 |
Reardon B, Beliakova-Bethell N, Spina CA, Singhania A, Margolis DM, Richman DR, Woelk CH. Dose-responsive gene expression in suberoylanilide hydroxamic acid-treated resting CD4+ T cells. Aids (London, England). 29: 2235-2244. PMID 26258524 DOI: 10.1097/Qad.0000000000000839 |
0.551 |
|
| 2015 |
Schrier RD, Hong S, Crescini M, Ellis R, Pérez-Santiago J, Spina C, Letendre S. Cerebrospinal fluid (CSF) CD8+ T-cells that express interferon-gamma contribute to HIV associated neurocognitive disorders (HAND). Plos One. 10: e0116526. PMID 25719800 DOI: 10.1371/Journal.Pone.0116526 |
0.588 |
|
| 2014 |
Murry JP, Godoy J, Mukim A, Swann J, Bruce JW, Ahlquist P, Bosque A, Planelles V, Spina CA, Young JA. Sulfonation pathway inhibitors block reactivation of latent HIV-1. Virology. 471: 1-12. PMID 25310595 DOI: 10.1016/J.Virol.2014.08.016 |
0.59 |
|
| 2014 |
Gianella S, Massanella M, Richman DD, Little SJ, Spina CA, Vargas MV, Lada SM, Daar ES, Dube MP, Haubrich RH, Morris SR, Smith DM. Cytomegalovirus replication in semen is associated with higher levels of proviral HIV DNA and CD4+ T cell activation during antiretroviral treatment. Journal of Virology. 88: 7818-27. PMID 24789781 DOI: 10.1128/Jvi.00831-14 |
0.634 |
|
| 2014 |
Beliakova-Bethell N, Jain S, Woelk CH, Witt MD, Sun X, Lada SM, Spina CA, Goicoechea M, Rought SE, Haubrich R, Dubé MP. Maraviroc intensification in patients with suppressed HIV viremia has limited effects on CD4+ T cell recovery and gene expression. Antiviral Research. 107: 42-9. PMID 24769244 DOI: 10.1016/J.Antiviral.2014.04.005 |
0.509 |
|
| 2014 |
Wei DG, Chiang V, Fyne E, Balakrishnan M, Barnes T, Graupe M, Hesselgesser J, Irrinki A, Murry JP, Stepan G, Stray KM, Tsai A, Yu H, Spindler J, Kearney M, ... Spina CA, et al. Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing. Plos Pathogens. 10: e1004071. PMID 24722454 DOI: 10.1371/Journal.Ppat.1004071 |
0.648 |
|
| 2014 |
Karris MY, Kao YT, Patel D, Dawson M, Woods SP, Vaida F, Spina C, Richman D, Little S, Smith DM. Predictors of virologic response in persons who start antiretroviral therapy during recent HIV infection. Aids (London, England). 28: 841-9. PMID 24401640 DOI: 10.1097/Qad.0000000000000149 |
0.529 |
|
| 2014 |
Beliakova-Bethell N, Massanella M, White C, Lada SM, Du P, Vaida F, Blanco J, Spina CA, Woelk CH. The effect of cell subset isolation method on gene expression in leukocytes. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 85: 94-104. PMID 24115734 DOI: 10.1002/Cyto.A.22352 |
0.367 |
|
| 2013 |
Spina CA, Anderson J, Archin NM, Bosque A, Chan J, Famiglietti M, Greene WC, Kashuba A, Lewin SR, Margolis DM, Mau M, Ruelas D, Saleh S, Shirakawa K, Siliciano RF, et al. An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients. Plos Pathogens. 9: e1003834. PMID 24385908 DOI: 10.1371/Journal.Ppat.1003834 |
0.597 |
|
| 2013 |
Pérez-Santiago J, Gianella S, Massanella M, Spina CA, Karris MY, Var SR, Patel D, Jordan PS, Young JA, Little SJ, Richman DD, Smith DM. Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection. Aids (London, England). 27: 1921-31. PMID 24180001 DOI: 10.1097/Qad.0B013E3283611816 |
0.603 |
|
| 2013 |
Strain MC, Lada SM, Luong T, Rought SE, Gianella S, Terry VH, Spina CA, Woelk CH, Richman DD. Highly precise measurement of HIV DNA by droplet digital PCR. Plos One. 8: e55943. PMID 23573183 DOI: 10.1371/Journal.Pone.0055943 |
0.522 |
|
| 2013 |
Marcondes MC, Spina C, Bustamante E, Fox H. Increased toll-like receptor signaling pathways characterize CD8+ cells in rapidly progressive SIV infection. Biomed Research International. 2013: 796014. PMID 23484159 DOI: 10.1155/2013/796014 |
0.552 |
|
| 2013 |
Beliakova-Bethell N, Zhang JX, Singhania A, Lee V, Terry VH, Richman DD, Spina CA, Woelk CH. Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4(+) T cells. Aids (London, England). 27: 29-37. PMID 23221426 DOI: 10.1097/Qad.0B013E32835B3E26 |
0.437 |
|
| 2013 |
Soto PC, Karris MY, Spina CA, Richman DD, Varki A. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells. Journal of Molecular Medicine (Berlin, Germany). 91: 261-70. PMID 22945238 DOI: 10.1007/S00109-012-0951-7 |
0.646 |
|
| 2013 |
Gianella S, Morris SR, Anderson C, Spina CA, Vargas MV, Young JA, Richman DD, Little SJ, Smith DM. Herpes viruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract. Aids (London, England). 27: 39-47. PMID 22739399 DOI: 10.1097/Qad.0B013E3283573305 |
0.635 |
|
| 2012 |
Razooky BS, Gutierrez E, Terry VH, Spina CA, Groisman A, Weinberger LS. Microwell devices with finger-like channels for long-term imaging of HIV-1 expression kinetics in primary human lymphocytes. Lab On a Chip. 12: 4305-12. PMID 22976503 DOI: 10.1039/C2Lc40170C |
0.578 |
|
| 2012 |
Gianella S, Strain MC, Rought SE, Vargas MV, Little SJ, Richman DD, Spina CA, Smith DM. Associations between virologic and immunologic dynamics in blood and in the male genital tract. Journal of Virology. 86: 1307-15. PMID 22114342 DOI: 10.1128/Jvi.06077-11 |
0.607 |
|
| 2011 |
Terry VH, Johnston ICD, Spina CA. Corrigendum to "CD44 MicroBeads accelerate HIV-1 infection in T cells" [Virology 388 (2009) 294-304] Virology. 419: 54-55. DOI: 10.1016/J.Virol.2011.08.001 |
0.581 |
|
| 2009 |
Goicoechea M, Smith D, May S, Mathews C, Spina C. Prevalence and T-cell phenotype of slow HIV disease progressors with robust HIV replication. Journal of Acquired Immune Deficiency Syndromes (1999). 52: 299-301. PMID 20118679 DOI: 10.1097/Qai.0B013E3181B08D70 |
0.587 |
|
| 2009 |
Terry VH, Johnston IC, Spina CA. CD44 microbeads accelerate HIV-1 infection in T cells. Virology. 388: 294-304. PMID 19394995 DOI: 10.1016/J.Virol.2009.03.022 |
0.661 |
|
| 2008 |
Koelsch KK, Liu L, Haubrich R, May S, Havlir D, Günthard HF, Ignacio CC, Campos-Soto P, Little SJ, Shafer R, Robbins GK, D'Aquila RT, Kawano Y, Young K, Dao P, ... Spina CA, et al. Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro. The Journal of Infectious Diseases. 197: 411-9. PMID 18248304 DOI: 10.1086/525283 |
0.589 |
|
| 2006 |
Stone GW, Barzee S, Snarsky V, Spina CA, Lifson JD, Pillai VK, Amara RR, Villinger F, Kornbluth RS. Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro. Clinical and Vaccine Immunology : Cvi. 13: 1223-30. PMID 16988005 DOI: 10.1128/Cvi.00198-06 |
0.496 |
|
| 2006 |
Stone GW, Barzee S, Snarsky V, Kee K, Spina CA, Yu XF, Kornbluth RS. Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines. Journal of Virology. 80: 1762-72. PMID 16439533 DOI: 10.1128/Jvi.80.4.1762-1772.2006 |
0.488 |
|
| 2005 |
Lehrman G, Hogue IB, Palmer S, Jennings C, Spina CA, Wiegand A, Landay AL, Coombs RW, Richman DD, Mellors JW, Coffin JM, Bosch RJ, Margolis DM. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet. 366: 549-55. PMID 16099290 DOI: 10.1016/S0140-6736(05)67098-5 |
0.64 |
|
| 2005 |
Strain MC, Little SJ, Daar ES, Havlir DV, Gunthard HF, Lam RY, Daly OA, Nguyen J, Ignacio CC, Spina CA, Richman DD, Wong JK. Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1. The Journal of Infectious Diseases. 191: 1410-8. PMID 15809898 DOI: 10.1086/428777 |
0.566 |
|
| 2004 |
Dong T, Stewart-Jones G, Chen N, Easterbrook P, Xu X, Papagno L, Appay V, Weekes M, Conlon C, Spina C, Little S, Screaton G, van der Merwe A, Richman DD, McMichael AJ, et al. HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor. The Journal of Experimental Medicine. 200: 1547-57. PMID 15596521 DOI: 10.1084/Jem.20032044 |
0.574 |
|
| 2004 |
Papagno L, Spina CA, Marchant A, Salio M, Rufer N, Little S, Dong T, Chesney G, Waters A, Easterbrook P, Dunbar PR, Shepherd D, Cerundolo V, Emery V, Griffiths P, et al. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. Plos Biology. 2: E20. PMID 14966528 DOI: 10.1371/Journal.Pbio.0020020 |
0.674 |
|
| 2003 |
Strain MC, Günthard HF, Havlir DV, Ignacio CC, Smith DM, Leigh-Brown AJ, Macaranas TR, Lam RY, Daly OA, Fischer M, Opravil M, Levine H, Bacheler L, Spina CA, Richman DD, et al. Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence. Proceedings of the National Academy of Sciences of the United States of America. 100: 4819-24. PMID 12684537 DOI: 10.1073/Pnas.0736332100 |
0.6 |
|
| 2002 |
Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GM, Papagno L, Ogg GS, King A, Lechner F, Spina CA, Little S, Havlir DV, Richman DD, Gruener N, Pape G, et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nature Medicine. 8: 379-85. PMID 11927944 DOI: 10.1038/Nm0402-379 |
0.567 |
|
| 2002 |
Appay V, Papagno L, Spina CA, Hansasuta P, King A, Jones L, Ogg GS, Little S, McMichael AJ, Richman DD, Rowland-Jones SL. Dynamics of T cell responses in HIV infection. Journal of Immunology (Baltimore, Md. : 1950). 168: 3660-6. PMID 11907132 DOI: 10.4049/Jimmunol.168.7.3660 |
0.641 |
|
| 2002 |
Appay V, Hansasuta P, Sutton J, Schrier RD, Wong JK, Furtado M, Havlir DV, Wolinsky SM, McMichael AJ, Richman DD, Rowland-Jones SL, Spina CA. Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression. Aids (London, England). 16: 161-70. PMID 11807299 DOI: 10.1097/00002030-200201250-00004 |
0.642 |
|
| 2000 |
Appay V, Nixon DF, Donahoe SM, Gillespie GM, Dong T, King A, Ogg GS, Spiegel HM, Conlon C, Spina CA, Havlir DV, Richman DD, Waters A, Easterbrook P, McMichael AJ, et al. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. The Journal of Experimental Medicine. 192: 63-75. PMID 10880527 DOI: 10.1084/Jem.192.1.63 |
0.644 |
|
| 2000 |
Günthard HF, Wong JK, Spina CA, Ignacio C, Kwok S, Christopherson C, Hwang J, Haubrich R, Havlir D, Richman DD. Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy. The Journal of Infectious Diseases. 181: 522-31. PMID 10669335 DOI: 10.1086/315260 |
0.56 |
|
| 1999 |
Günthard HF, Frost SD, Leigh-Brown AJ, Ignacio CC, Kee K, Perelson AS, Spina CA, Havlir DV, Hezareh M, Looney DJ, Richman DD, Wong JK. Evolution of envelope sequences of human immunodeficiency virus type 1 in cellular reservoirs in the setting of potent antiviral therapy. Journal of Virology. 73: 9404-12. PMID 10516049 DOI: 10.1128/Jvi.73.11.9404-9412.1999 |
0.492 |
|
| 1999 |
Little SJ, McLean AR, Spina CA, Richman DD, Havlir DV. Viral dynamics of acute HIV-1 infection. The Journal of Experimental Medicine. 190: 841-50. PMID 10499922 DOI: 10.1084/Jem.190.6.841 |
0.577 |
|
| 1997 |
Wong JK, Hezareh M, Günthard HF, Havlir DV, Ignacio CC, Spina CA, Richman DD. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science (New York, N.Y.). 278: 1291-5. PMID 9360926 DOI: 10.1126/Science.278.5341.1291 |
0.608 |
|
| 1997 |
Spina CA, Prince HE, Richman DD. Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro. The Journal of Clinical Investigation. 99: 1774-85. PMID 9120023 DOI: 10.1172/Jci119342 |
0.65 |
|
| 1996 |
Schrier RD, Wiley CA, Spina C, McCutchan JA, Grant I. Pathogenic and protective correlates of T cell proliferation in AIDS. HNRC Group. HIV Neurobehavioral Research Center. The Journal of Clinical Investigation. 98: 731-40. PMID 8698865 DOI: 10.1172/Jci118845 |
0.637 |
|
| 1996 |
Pandori MW, Fitch NJ, Craig HM, Richman DD, Spina CA, Guatelli JC. Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein. Journal of Virology. 70: 4283-90. PMID 8676450 DOI: 10.1128/Jvi.70.7.4283-4290.1996 |
0.485 |
|
| 1995 |
Spina CA, Guatelli JC, Richman DD. Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro Journal of Virology. 69: 2977-2988. PMID 7707524 DOI: 10.1128/Jvi.69.5.2977-2988.1995 |
0.64 |
|
| 1995 |
Chowers MY, Pandori MW, Spina CA, Richman DD, Guatelli JC. The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. Virology. 212: 451-7. PMID 7571414 DOI: 10.1006/Viro.1995.1502 |
0.532 |
|
| 1994 |
Chowers MY, Spina CA, Kwoh TJ, Fitch NJ, Richman DD, Guatelli JC. Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. Journal of Virology. 68: 2906-14. PMID 8151761 DOI: 10.1128/Jvi.68.5.2906-2914.1994 |
0.457 |
|
| 1994 |
Little SJ, Riggs NL, Chowers MY, Fitch NJ, Richman DD, Spina CA, Guatelli JC. Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1. Virology. 205: 578-82. PMID 7975260 DOI: 10.1006/Viro.1994.1683 |
0.604 |
|
| 1994 |
Spina CA, Kwoh TJ, Chowers MY, Guatelli JC, Richman DD. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes Journal of Experimental Medicine. 179: 115-123. PMID 7903679 DOI: 10.1084/Jem.179.1.115 |
0.619 |
|
| 1993 |
Meylan PRA, Spina CA, Richman DD, Kornbluth RS. In vitro differentiation of monocytoid THP-1 cells affects their permissiveness for HIV strains: A model system for studying the cellular basis of HIV differential tropism Virology. 193: 256-267. PMID 8438570 DOI: 10.1006/Viro.1993.1121 |
0.639 |
|
| 1990 |
Zarling JM, Moran PA, Haffar O, Sias J, Richman DD, Spina CA, Myers DE, Kuebelbeck V, Ledbetter JA, Uckun FM. Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies Nature. 347: 92-95. PMID 1975641 DOI: 10.1038/347092A0 |
0.63 |
|
| 1981 |
Spina CA, Diane S, Korn E, Fahey JL, Grossman HJ. Altered Cellular Immune Functions in Patients With Down's Syndrome Jama Pediatrics. 135: 251-255. PMID 6452055 DOI: 10.1001/Archpedi.1981.02130270043015 |
0.372 |
|
| 1976 |
Chang RS, Spina CA. In Vitro Stimulation of Lymphocytes of Donors Seronegative for Epstein-Barr Virus by Preparations of Inactivated Epstein-Barr Virus The Journal of Infectious Diseases. 133: 676-680. PMID 180190 DOI: 10.1093/Infdis/133.6.676 |
0.349 |
|
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