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Douglas R. Davies, Ph.D. - Publications

Affiliations: 
2000 University of Wisconsin, Madison, Madison, WI 
Area:
Structural Biology
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Rai G, Urban DJ, Mott BT, Hu X, Yang SM, Benavides GA, Johnson MS, Squadrito GL, Brimacombe KR, Lee TD, Cheff DM, Zhu H, Henderson MJ, Pohida K, Sulikowski GA, ... ... Davies DR, et al. Pyrazole-Based Lactate Dehydrogenase (LDH) Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. Journal of Medicinal Chemistry. PMID 32902275 DOI: 10.1021/Acs.Jmedchem.0C00916  0.319
2018 Dumais M, Davies DR, Lin T, Staker BL, Myler PJ, Van Voorhis WC. Structure and analysis of nucleoside diphosphate kinase from Borrelia burgdorferi prepared in a transition-state complex with ADP and vanadate moieties. Acta Crystallographica. Section F, Structural Biology Communications. 74: 373-384. PMID 29870023 DOI: 10.1107/S2053230X18007392  0.426
2017 Rai G, Brimacombe KR, Mott BT, Urban DJ, Hu X, Yang SM, Lee TD, Cheff DM, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci DK, Lukacs CM, Davies DR, et al. Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). Journal of Medicinal Chemistry. PMID 29120638 DOI: 10.1021/Acs.Jmedchem.7B00941  0.313
2016 Ojo KK, Ranade RM, Zhang Z, Dranow DM, Myers JB, Choi R, Nakazawa Hewitt S, Edwards TE, Davies DR, Lorimer D, Boyle SM, Barrett LK, Buckner FS, Fan E, Van Voorhis WC. Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. Plos One. 11: e0160350. PMID 27500735 DOI: 10.1371/Journal.Pone.0160350  0.36
2016 Gelinas AD, Davies DR, Janjic N. Embracing proteins: structural themes in aptamer-protein complexes. Current Opinion in Structural Biology. 36: 122-132. PMID 26919170 DOI: 10.1016/J.Sbi.2016.01.009  0.398
2015 Jarvis TC, Davies DR, Hisaminato A, Resnicow DI, Gupta S, Waugh SM, Nagabukuro A, Wadatsu T, Hishigaki H, Gawande B, Zhang C, Wolk SK, Mayfield WS, Nakaishi Y, Burgin AB, et al. Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor. Structure (London, England : 1993). 23: 1293-304. PMID 26027732 DOI: 10.1016/J.Str.2015.03.027  0.396
2015 Phan IQ, Davies DR, Moretti NS, Shanmugam D, Cestari I, Anupama A, Fairman JW, Edwards TE, Stuart K, Schenkman S, Myler PJ. Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures. Acta Crystallographica. Section F, Structural Biology Communications. 71: 615-21. PMID 25961325 DOI: 10.1107/S2053230X15004185  0.35
2014 Gelinas AD, Davies DR, Edwards TE, Rohloff JC, Carter JD, Zhang C, Gupta S, Ishikawa Y, Hirota M, Nakaishi Y, Jarvis TC, Janjic N. Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand. The Journal of Biological Chemistry. 289: 8720-34. PMID 24415767 DOI: 10.1074/Jbc.M113.532697  0.346
2012 Davies DR, Gelinas AD, Zhang C, Rohloff JC, Carter JD, O'Connell D, Waugh SM, Wolk SK, Mayfield WS, Burgin AB, Edwards TE, Stewart LJ, Gold L, Janjic N, Jarvis TC. Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets. Proceedings of the National Academy of Sciences of the United States of America. 109: 19971-6. PMID 23139410 DOI: 10.1073/Pnas.1213933109  0.394
2011 Begley DW, Davies DR, Hartley RC, Hewitt SN, Rychel AL, Myler PJ, Van Voorhis WC, Staker BL, Stewart LJ. Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1060-9. PMID 21904051 DOI: 10.1107/S1744309111014436  0.408
2011 Davies DR, Staker BL, Abendroth JA, Edwards TE, Hartley R, Leonard J, Kim H, Rychel AL, Hewitt SN, Myler PJ, Stewart LJ. An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1044-50. PMID 21904048 DOI: 10.1107/S1744309111030405  0.341
2011 Begley DW, Davies DR, Hartley RC, Edwards TE, Staker BL, Van Voorhis WC, Myler PJ, Stewart LJ. Fragment screening of infectious disease targets in a structural genomics environment. Methods in Enzymology. 493: 533-56. PMID 21371605 DOI: 10.1016/B978-0-12-381274-2.00021-2  0.387
2011 Davies DR, Begley DW, Hartley RC, Staker BL, Stewart LJ. Predicting the success of fragment screening by X-ray crystallography. Methods in Enzymology. 493: 91-114. PMID 21371588 DOI: 10.1016/B978-0-12-381274-2.00004-2  0.342
2011 Begley DW, Hartley RC, Davies DR, Edwards TE, Leonard JT, Abendroth J, Burris CA, Bhandari J, Myler PJ, Staker BL, Stewart LJ. Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. Journal of Structural and Functional Genomics. 12: 63-76. PMID 21359640 DOI: 10.1007/S10969-011-9102-6  0.44
2010 Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, ... ... Davies DR, et al. Climate change and the integrity of science. Science (New York, N.Y.). 328: 689-90. PMID 20448167 DOI: 10.1126/Science.328.5979.689  0.306
2010 Fitzkee NC, Masse JE, Shen Y, Davies DR, Bax A. Solution conformation and dynamics of the HIV-1 integrase core domain. The Journal of Biological Chemistry. 285: 18072-84. PMID 20363759 DOI: 10.1074/Jbc.M110.113407  0.312
2010 Davies DR, Mamat B, Magnusson OT, Christensen J, Haraldsson MH, Mishra R, Pease B, Hansen E, Singh J, Zembower D, Kim H, Kiselyov AS, Burgin AB, Gurney ME, Stewart LJ. Corrections to Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography Journal of Medicinal Chemistry. 53: 2330-2331. DOI: 10.1021/Jm100015W  0.328
2010 Carlson AE, Brelidze TI, Davies DR, Zagotta W. Flavonoids Regulate Eag1 Channels Biophysical Journal. 98: 1a. DOI: 10.1016/J.Bpj.2009.11.037  0.304
2009 Davies DR, Mamat B, Magnusson OT, Christensen J, Haraldsson MH, Mishra R, Pease B, Hansen E, Singh J, Zembower D, Kim H, Kiselyov AS, Burgin AB, Gurney ME, Stewart LJ. Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. Journal of Medicinal Chemistry. 52: 4694-715. PMID 19618939 DOI: 10.1021/Jm900259H  0.389
2008 Evans RJ, Davies DR, Bullard JM, Christensen J, Green LS, Guiles JW, Pata JD, Ribble WK, Janjic N, Jarvis TC. Structure of PolC reveals unique DNA binding and fidelity determinants. Proceedings of the National Academy of Sciences of the United States of America. 105: 20695-700. PMID 19106298 DOI: 10.1073/Pnas.0809989106  0.457
2006 Davies DR, Mushtaq A, Interthal H, Champoux JJ, Hol WG. The structure of the transition state of the heterodimeric topoisomerase I of Leishmania donovani as a vanadate complex with nicked DNA. Journal of Molecular Biology. 357: 1202-10. PMID 16487540 DOI: 10.1016/J.Jmb.2006.01.022  0.437
2004 Davies DR, Hol WG. The power of vanadate in crystallographic investigations of phosphoryl transfer enzymes. Febs Letters. 577: 315-21. PMID 15556602 DOI: 10.1016/J.Febslet.2004.10.022  0.324
2004 Davies DR, Interthal H, Champoux JJ, Hol WG. Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. Journal of Medicinal Chemistry. 47: 829-37. PMID 14761185 DOI: 10.1021/Jm030487X  0.391
2003 Davies DR, Interthal H, Champoux JJ, Hol WG. Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide. Chemistry & Biology. 10: 139-47. PMID 12618186 DOI: 10.1016/S1074-5521(03)00021-8  0.407
2002 Davies DR, Interthal H, Champoux JJ, Hol WG. Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures. Journal of Molecular Biology. 324: 917-32. PMID 12470949 DOI: 10.1016/S0022-2836(02)01154-3  0.43
2002 Davies DR, Interthal H, Champoux JJ, Hol WG. The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1. Structure (London, England : 1993). 10: 237-48. PMID 11839309 DOI: 10.1016/S0969-2126(02)00707-4  0.456
2000 Umland TC, Wei SQ, Craigie R, Davies DR. Structural basis of DNA bridging by barrier-to-autointegration factor. Biochemistry. 39: 9130-8. PMID 10924106 DOI: 10.1021/Bi000572W  0.333
2000 Davies DR, Goryshin IY, Reznikoff WS, Rayment I. Three-dimensional structure of the Tn5 synaptic complex transposition intermediate. Science (New York, N.Y.). 289: 77-85. PMID 10884228 DOI: 10.1126/Science.289.5476.77  0.565
2000 Davies DR. Paul sigler Structure (London, England : 1993). 8: R67-8. PMID 10745016 DOI: 10.1016/S0969-2126(00)00113-1  0.301
1999 Reznikoff WS, Bhasin A, Davies DR, Goryshin IY, Mahnke LA, Naumann T, Rayment I, Steiniger-White M, Twining SS. Tn5: A molecular window on transposition. Biochemical and Biophysical Research Communications. 266: 729-34. PMID 10603311 DOI: 10.1006/Bbrc.1999.1891  0.52
1999 Davies DR, Mahnke Braam L, Reznikoff WS, Rayment I. The three-dimensional structure of a Tn5 transposase-related protein determined to 2.9-A resolution. The Journal of Biological Chemistry. 274: 11904-13. PMID 10207011 DOI: 10.1074/Jbc.274.17.11904  0.555
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