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Karlene A. Cimprich - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
Area:
DNA damage response
Website:
http://med.stanford.edu/profiles/Karlene_Cimprich/
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65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Bai G, Endres T, Kühbacher U, Mengoli V, Greer BH, Peacock EM, Newton MD, Stanage T, Dello Stritto MR, Lungu R, Crossley MP, Sathirachinda A, Cortez D, Boulton SJ, Cejka P, ... ... Cimprich KA, et al. HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability. Molecular Cell. PMID 39142279 DOI: 10.1016/j.molcel.2024.07.018  0.347
2024 Crossley MP, Song C, Bocek MJ, Choi JH, Kousouros JN, Sathirachinda A, Lin C, Brickner JR, Bai G, Lans H, Vermeulen W, Abu-Remaileh M, Cimprich KA. Author Correction: R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response. Nature. PMID 38263519 DOI: 10.1038/s41586-024-07064-1  0.35
2023 Bai G, Endres T, Kühbacher U, Greer BH, Peacock EM, Crossley MP, Sathirachinda A, Cortez D, Eichman BF, Cimprich KA. HLTF Prevents G4 Accumulation and Promotes G4-induced Fork Slowing to Maintain Genome Stability. Biorxiv : the Preprint Server For Biology. PMID 37961428 DOI: 10.1101/2023.10.27.563641  0.311
2023 Cimprich KA, Li GM, Demaria S, Gekara NO, Zha S, Chen Q. The crosstalk between DNA repair and immune responses. Molecular Cell. 83: 3582-3587. PMID 37863025 DOI: 10.1016/j.molcel.2023.09.022  0.423
2023 Stoy H, Zwicky K, Kuster D, Lang KS, Krietsch J, Crossley MP, Schmid JA, Cimprich KA, Merrikh H, Lopes M. Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids. Nature Structural & Molecular Biology. 30: 348-359. PMID 36864174 DOI: 10.1038/s41594-023-00928-6  0.447
2022 Crossley MP, Song C, Bocek MJ, Choi JH, Kousorous J, Sathirachinda A, Lin C, Brickner JR, Bai G, Lans H, Vermeulen W, Abu-Remaileh M, Cimprich KA. R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response. Nature. PMID 36544021 DOI: 10.1038/s41586-022-05545-9  0.383
2022 Crossley MP, Cimprich KA. Quantitative DNA-RNA Immunoprecipitation Sequencing with Spike-Ins. Methods in Molecular Biology (Clifton, N.J.). 2528: 381-410. PMID 35704206 DOI: 10.1007/978-1-0716-2477-7_26  0.34
2022 Brickner JR, Garzon JL, Cimprich KA. Walking a tightrope: The complex balancing act of R-loops in genome stability. Molecular Cell. PMID 35508167 DOI: 10.1016/j.molcel.2022.04.014  0.435
2021 Crossley MP, Brickner JR, Song C, Zar SMT, Maw SS, Chédin F, Tsai MS, Cimprich KA. Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA-DNA hybrid imaging. The Journal of Cell Biology. 220. PMID 34232287 DOI: 10.1083/jcb.202101092  0.344
2020 Crossley MP, Bocek MJ, Hamperl S, Swigut T, Cimprich KA. qDRIP: a method to quantitatively assess RNA-DNA hybrid formation genome-wide. Nucleic Acids Research. PMID 32544226 DOI: 10.1093/Nar/Gkaa500  0.776
2020 Bai G, Kermi C, Stoy H, Schiltz CJ, Bacal J, Zaino AM, Hadden MK, Eichman BF, Lopes M, Cimprich KA. HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis. Molecular Cell. PMID 32442397 DOI: 10.1016/J.Molcel.2020.04.031  0.55
2019 Crossley MP, Bocek M, Cimprich KA. R-Loops as Cellular Regulators and Genomic Threats. Molecular Cell. 73: 398-411. PMID 30735654 DOI: 10.1016/J.Molcel.2019.01.024  0.51
2019 Li CG, Mahon C, Sweeney NM, Verschueren E, Kantamani V, Li D, Hennigs JK, Marciano DP, Diebold I, Abu-Halawa O, Elliott M, Sa S, Guo F, Wang L, Cao A, ... ... Cimprich KA, et al. PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis. Cell Reports. 26: 1333-1343.e7. PMID 30699358 DOI: 10.1016/J.Celrep.2019.01.013  0.584
2018 Saldivar JC, Hamperl S, Bocek MJ, Chung M, Bass TE, Cisneros-Soberanis F, Samejima K, Xie L, Paulson JR, Earnshaw WC, Cortez D, Meyer T, Cimprich KA. An intrinsic S/G checkpoint enforced by ATR. Science (New York, N.Y.). 361: 806-810. PMID 30139873 DOI: 10.1126/Science.Aap9346  0.779
2018 Daigh LH, Liu C, Chung M, Cimprich KA, Meyer T. Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates. Cell Systems. PMID 29909278 DOI: 10.1016/J.Cels.2018.05.011  0.546
2018 Crossley MP, Cimprich KA. Faulty replication can sting. Nature. 557: 34-35. PMID 29713064 DOI: 10.1038/D41586-018-02804-6  0.45
2018 Saldivar JC, Cimprich KA. A new mitotic activity comes into focus. Science (New York, N.Y.). 359: 30-31. PMID 29302000 DOI: 10.1126/Science.Aar4799  0.468
2017 Saldivar JC, Cortez D, Cimprich KA. Publisher correction: The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nature Reviews. Molecular Cell Biology. PMID 29115300 DOI: 10.1038/Nrm.2017.116  0.31
2017 Saldivar JC, Cortez D, Cimprich KA. The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nature Reviews. Molecular Cell Biology. PMID 28811666 DOI: 10.1038/Nrm.2017.67  0.592
2017 Hamperl S, Bocek MJ, Saldivar JC, Swigut T, Cimprich KA. Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses. Cell. 170: 774-786.e19. PMID 28802045 DOI: 10.1016/J.Cell.2017.07.043  0.784
2016 Hamperl S, Cimprich KA. Conflict Resolution in the Genome: How Transcription and Replication Make It Work. Cell. 167: 1455-1467. PMID 27912056 DOI: 10.1016/J.Cell.2016.09.053  0.753
2016 Hess GT, Frésard L, Han K, Lee CH, Li A, Cimprich KA, Montgomery SB, Bassik MC. Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells. Nature Methods. PMID 27798611 DOI: 10.1038/Nmeth.4038  0.337
2016 Stork CT, Bocek M, Crossley MP, Sollier J, Sanz LA, Chédin F, Swigut T, Cimprich KA. Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage. Elife. 5. PMID 27552054 DOI: 10.7554/Elife.17548  0.481
2016 Stork CT, Bocek M, Crossley MP, Sollier J, Sanz LA, Chédin F, Swigut T, Cimprich KA. Author response: Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage Elife. DOI: 10.7554/Elife.17548.041  0.511
2015 Slaats GG, Saldivar JC, Bacal J, Zeman MK, Kile AC, Hynes AM, Srivastava S, Nazmutdinova J, Ouden KD, Zagers MS, Foletto V, Verhaar MC, Miles C, Sayer JA, Cimprich KA, et al. DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome. The Journal of Clinical Investigation. PMID 26301811 DOI: 10.1172/Jci80657  0.521
2015 Kile AC, Chavez DA, Bacal J, Eldirany S, Korzhnev DM, Bezsonova I, Eichman BF, Cimprich KA. HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal. Molecular Cell. 58: 1090-100. PMID 26051180 DOI: 10.1016/J.Molcel.2015.05.013  0.616
2015 Sollier J, Cimprich KA. Breaking bad: R-loops and genome integrity. Trends in Cell Biology. PMID 26045257 DOI: 10.1016/J.Tcb.2015.05.003  0.533
2014 Sollier J, Stork CT, García-Rubio ML, Paulsen RD, Aguilera A, Cimprich KA. Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability. Molecular Cell. 56: 777-85. PMID 25435140 DOI: 10.1016/J.Molcel.2014.10.020  0.602
2014 Zeman MK, Lin JR, Freire R, Cimprich KA. DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. The Journal of Cell Biology. 206: 183-97. PMID 25023518 DOI: 10.1083/Jcb.201311063  0.614
2014 Hamperl S, Cimprich KA. The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability. Dna Repair. 19: 84-94. PMID 24746923 DOI: 10.1016/J.Dnarep.2014.03.023  0.822
2014 Zeman MK, Cimprich KA. Causes and consequences of replication stress. Nature Cell Biology. 16: 2-9. PMID 24366029 DOI: 10.1038/Ncb2897  0.522
2013 Choi HJ, Lin JR, Vannier JB, Slaats GG, Kile AC, Paulsen RD, Manning DK, Beier DR, Giles RH, Boulton SJ, Cimprich KA. NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies. Molecular Cell. 51: 423-39. PMID 23973373 DOI: 10.1016/J.Molcel.2013.08.006  0.464
2013 Machado LE, Pustovalova Y, Kile AC, Pozhidaeva A, Cimprich KA, Almeida FC, Bezsonova I, Korzhnev DM. PHD domain from human SHPRH. Journal of Biomolecular Nmr. 56: 393-9. PMID 23907177 DOI: 10.1007/S10858-013-9758-2  0.334
2013 Couch FB, Bansbach CE, Driscoll R, Luzwick JW, Glick GG, Bétous R, Carroll CM, Jung SY, Qin J, Cimprich KA, Cortez D. ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes & Development. 27: 1610-23. PMID 23873943 DOI: 10.1101/Gad.214080.113  0.664
2013 Duursma AM, Driscoll R, Elias JE, Cimprich KA. A role for the MRN complex in ATR activation via TOPBP1 recruitment. Molecular Cell. 50: 116-22. PMID 23582259 DOI: 10.1016/J.Molcel.2013.03.006  0.652
2011 Lin JR, Zeman MK, Chen JY, Yee MC, Cimprich KA. SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis. Molecular Cell. 42: 237-49. PMID 21396873 DOI: 10.1016/J.Molcel.2011.02.026  0.557
2010 Duursma AM, Cimprich KA. Checkpoint recovery after DNA damage: a rolling stop for CDKs. Embo Reports. 11: 411-2. PMID 20467435 DOI: 10.1038/Embor.2010.76  0.629
2010 Van C, Yan S, Michael WM, Waga S, Cimprich KA. Continued primer synthesis at stalled replication forks contributes to checkpoint activation. The Journal of Cell Biology. 189: 233-46. PMID 20385778 DOI: 10.1083/Jcb.200909105  0.658
2009 Driscoll R, Cimprich KA. HARPing on about the DNA damage response during replication. Genes & Development. 23: 2359-65. PMID 19833762 DOI: 10.1101/Gad.1860609  0.593
2009 Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Molecular Cell. 35: 228-39. PMID 19647519 DOI: 10.1016/J.Molcel.2009.06.021  0.565
2009 Kochaniak AB, Habuchi S, Loparo JJ, Chang DJ, Cimprich KA, Walter JC, van Oijen AM. Proliferating cell nuclear antigen uses two distinct modes to move along DNA. The Journal of Biological Chemistry. 284: 17700-10. PMID 19411704 DOI: 10.1074/Jbc.M109.008706  0.737
2009 Chang DJ, Cimprich KA. DNA damage tolerance: when it's OK to make mistakes. Nature Chemical Biology. 5: 82-90. PMID 19148176 DOI: 10.1038/Nchembio.139  0.755
2008 Cimprich KA, Cortez D. ATR: an essential regulator of genome integrity. Nature Reviews. Molecular Cell Biology. 9: 616-27. PMID 18594563 DOI: 10.1038/Nrm2450  0.654
2007 Cimprich KA. Probing ATR activation with model DNA templates. Cell Cycle (Georgetown, Tex.). 6: 2348-54. PMID 17700074 DOI: 10.4161/Cc.6.19.4755  0.666
2007 Paulsen RD, Cimprich KA. The ATR pathway: fine-tuning the fork. Dna Repair. 6: 953-66. PMID 17531546 DOI: 10.1016/J.Dnarep.2007.02.015  0.597
2007 MacDougall CA, Byun TS, Van C, Yee MC, Cimprich KA. The structural determinants of checkpoint activation. Genes & Development. 21: 898-903. PMID 17437996 DOI: 10.1101/Gad.1522607  0.768
2007 Lupardus PJ, Van C, Cimprich KA. Analyzing the ATR-mediated checkpoint using Xenopus egg extracts. Methods (San Diego, Calif.). 41: 222-31. PMID 17189864 DOI: 10.1016/J.Ymeth.2006.07.024  0.769
2006 Chang DJ, Lupardus PJ, Cimprich KA. Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities. The Journal of Biological Chemistry. 281: 32081-8. PMID 16959771 DOI: 10.1074/Jbc.M606799200  0.844
2006 Bomgarden RD, Lupardus PJ, Soni DV, Yee MC, Ford JM, Cimprich KA. Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling. The Embo Journal. 25: 2605-14. PMID 16675950 DOI: 10.1038/Sj.Emboj.7601123  0.806
2006 Lupardus PJ, Cimprich KA. Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus. Molecular Biology of the Cell. 17: 1559-69. PMID 16436514 DOI: 10.1091/Mbc.E05-09-0865  0.765
2006 Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, Joenje H, Christian JL, Lupardus PJ, Cimprich KA, Gautier J, et al. Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks. Molecular and Cellular Biology. 26: 425-37. PMID 16382135 DOI: 10.1128/Mcb.26.2.425-437.2006  0.803
2005 Yee MC, Fas SC, Stohlmeyer MM, Wandless TJ, Cimprich KA. A cell-permeable, activity-based probe for protein and lipid kinases. The Journal of Biological Chemistry. 280: 29053-9. PMID 15975929 DOI: 10.1074/Jbc.M504730200  0.639
2005 Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes & Development. 19: 1040-52. PMID 15833913 DOI: 10.1101/Gad.1301205  0.802
2005 O'Connell MJ, Cimprich KA. G2 damage checkpoints: what is the turn-on? Journal of Cell Science. 118: 1-6. PMID 15615778 DOI: 10.1242/Jcs.01626  0.672
2004 Lupardus PJ, Cimprich KA. Checkpoint adaptation; molecular mechanisms uncovered. Cell. 117: 555-6. PMID 15163402 DOI: 10.1016/J.Cell.2004.05.005  0.715
2004 Bomgarden RD, Yean D, Yee MC, Cimprich KA. A novel protein activity mediates DNA binding of an ATR-ATRIP complex. The Journal of Biological Chemistry. 279: 13346-53. PMID 14724280 DOI: 10.1074/Jbc.M311098200  0.803
2003 Barr SM, Leung CG, Chang EE, Cimprich KA. ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation. Current Biology : Cb. 13: 1047-51. PMID 12814551 DOI: 10.1016/S0960-9822(03)00376-2  0.654
2003 Cimprich KA. Fragile sites: breaking up over a slowdown. Current Biology : Cb. 13: R231-3. PMID 12646149 DOI: 10.1016/S0960-9822(03)00158-1  0.341
2003 Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Molecular Cell. 11: 203-13. PMID 12535533 DOI: 10.1016/S1097-2765(02)00799-2  0.814
2002 Lupardus PJ, Byun T, Yee MC, Hekmat-Nejad M, Cimprich KA. A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes & Development. 16: 2327-32. PMID 12231621 DOI: 10.1101/Gad.1013502  0.844
2001 Post S, Weng YC, Cimprich K, Chen LB, Xu Y, Lee EY. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 98: 13102-7. PMID 11687627 DOI: 10.1073/Pnas.231364598  0.549
2000 Hekmat-Nejad M, You Z, Yee MC, Newport JW, Cimprich KA. Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Current Biology : Cb. 10: 1565-73. PMID 11137007 DOI: 10.1016/S0960-9822(00)00855-1  0.624
1998 Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (New York, N.Y.). 281: 1677-9. PMID 9733515 DOI: 10.1126/Science.281.5383.1677  0.394
1998 Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL, Friend SH. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. The Embo Journal. 17: 159-69. PMID 9427750 DOI: 10.1093/Emboj/17.1.159  0.692
1996 Cimprich KA, Shin TB, Keith CT, Schreiber SL. cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proceedings of the National Academy of Sciences of the United States of America. 93: 2850-5. PMID 8610130 DOI: 10.1073/Pnas.93.7.2850  0.779
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