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Stuart L. Schreiber, Ph.D. - Publications

Affiliations: 
1981-1987 Chemistry Yale University, New Haven, CT 
 1988- Broad Institute Harvard University, Cambridge, MA, United States 
Area:
Chemical biology
Website:
http://www.broadinstitute.org/chembio/lab_schreiber/members/smdbSchreiberBio.php
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Year Citation  Score
2024 Ence CC, Uddin T, Borrel J, Mittal P, Xie H, Zoller J, Sharma A, Comer E, Schreiber SL, Melillo B, Sibley LD, Chatterjee AK. Bicyclic Pyrrolidine Inhibitors of Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure. Acs Infectious Diseases. PMID 38743643 DOI: 10.1021/acsinfecdis.4c00170  0.555
2024 Liu Z, Remsberg JR, Li H, Njomen E, DeMeester KE, Tao Y, Xia G, Hayward RE, Yoo M, Nguyen T, Simon GM, Schreiber SL, Melillo B, Cravatt BF. Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. Journal of the American Chemical Society. PMID 38569115 DOI: 10.1021/jacs.3c13448  0.755
2024 Ence CC, Uddin T, Borrel J, Mittal P, Xie H, Zoller J, Sharma A, Comer E, Schreiber SL, Melillo B, Sibley LD, Chatterjee AK. Bicyclic pyrrolidine inhibitors of phenylalanine t-RNA synthetase with antiparasitic potency and brain exposure. Biorxiv : the Preprint Server For Biology. PMID 38464220 DOI: 10.1101/2024.02.28.582607  0.554
2024 Li W, Garcia-Rivera EM, Mitchell DC, Chick JM, Maetani M, Knapp JM, Matthews GM, Shirasaki R, de Matos Simoes R, Viswanathan V, Pulice JL, Rees MG, Roth JA, Gygi SP, Mitsiades CS, ... ... Schreiber SL, et al. Highly specific intracellular ubiquitination of a small molecule. Biorxiv : the Preprint Server For Biology. PMID 38328167 DOI: 10.1101/2024.01.26.577493  0.751
2023 Gibson WJ, Sadagopan A, Shoba VM, Choudhary A, Meyerson M, Schreiber SL. Bifunctional Small Molecules That Induce Nuclear Localization and Targeted Transcriptional Regulation. Journal of the American Chemical Society. PMID 37992275 DOI: 10.1021/jacs.3c06179  0.811
2023 Hudson L, Mason JW, Westphal MV, Richter MJR, Thielman JR, Hua BK, Gerry CJ, Xia G, Osswald HL, Knapp JM, Tan ZY, Kokkonda P, Tresco BIC, Liu S, Reidenbach AG, ... ... Schreiber SL, et al. Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides. Nature Communications. 14: 7589. PMID 37989745 DOI: 10.1038/s41467-023-43518-2  0.766
2023 Mason JW, Chow YT, Hudson L, Tutter A, Michaud G, Westphal MV, Shu W, Ma X, Tan ZY, Coley CW, Clemons PA, Bonazzi S, Berst F, Briner K, Liu S, ... ... Schreiber SL, et al. DNA-encoded library-enabled discovery of proximity-inducing small molecules. Nature Chemical Biology. PMID 37919549 DOI: 10.1038/s41589-023-01458-4  0.606
2023 Hudson L, Mason JW, Westphal MV, Richter MJR, Thielman JR, Hua BK, Gerry CJ, Xia G, Osswald HL, Knapp JM, Tan ZY, Kokkonda P, Tresco BIC, Liu S, Reidenbach AG, ... ... Schreiber SL, et al. Diversity-oriented synthesis encoded by deoxyoligonucleotides. Nature Communications. 14: 4930. PMID 37582753 DOI: 10.1038/s41467-023-40575-5  0.803
2023 Gibson WJ, Sadagopan A, Shoba VM, Choudhary A, Meyerson M, Schreiber SL. Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation. Biorxiv : the Preprint Server For Biology. PMID 37461636 DOI: 10.1101/2023.07.07.548101  0.811
2023 Sharifnia T, Wawer MJ, Goodale A, Lee Y, Kazachkova M, Dempster JM, Muller S, Levy J, Freed DM, Sommer J, Kalfon J, Vazquez F, Hahn WC, Root DE, Clemons PA, ... Schreiber SL, et al. Mapping the landscape of genetic dependencies in chordoma. Nature Communications. 14: 1933. PMID 37024492 DOI: 10.1038/s41467-023-37593-8  0.563
2023 Dahlin JL, Hua BK, Zucconi BE, Nelson SD, Singh S, Carpenter AE, Shrimp JH, Lima-Fernandes E, Wawer MJ, Chung LPW, Agrawal A, O'Reilly M, Barsyte-Lovejoy D, Szewczyk M, Li F, ... ... Schreiber SL, et al. Reference compounds for characterizing cellular injury in high-content cellular morphology assays. Nature Communications. 14: 1364. PMID 36914634 DOI: 10.1038/s41467-023-36829-x  0.712
2021 Negi V, Yang J, Speyer G, Pulgarin A, Handen A, Zhao J, Tai YY, Tang Y, Culley MK, Yu Q, Forsythe P, Gorelova A, Watson AM, Al Aaraj Y, Satoh T, ... ... Schreiber SL, et al. Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension. Science Advances. 7: eabh3794. PMID 34669463 DOI: 10.1126/sciadv.abh3794  0.626
2021 Clemons PA, Bittker JA, Wagner FF, Hands A, Dančík V, Schreiber SL, Choudhary A, Wagner BK. The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes. Slas Discovery : Advancing Life Sciences R & D. 24725552211019410. PMID 34130532 DOI: 10.1177/24725552211019410  0.805
2021 Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, ... ... Schreiber SL, et al. An expanded universe of cancer targets. Cell. 184: 1142-1155. PMID 33667368 DOI: 10.1016/j.cell.2021.02.020  0.681
2021 Zou Y, Li H, Graham ET, Deik AA, Eaton JK, Wang W, Sandoval-Gomez G, Clish CB, Doench JG, Schreiber SL. Author Correction: Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nature Chemical Biology. PMID 33654315 DOI: 10.1038/s41589-021-00767-w  0.522
2021 Sheppard HE, Dall'Agnese A, Park WD, Shamim MH, Dubrulle J, Johnson HL, Stossi F, Cogswell P, Sommer J, Levy J, Sharifnia T, Wawer MJ, Nabet B, Gray NS, Clemons PA, ... Schreiber SL, et al. Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity. Cell Reports. Medicine. 2: 100188. PMID 33521702 DOI: 10.1016/j.xcrm.2020.100188  0.544
2021 Sharma M, Malhotra N, Yogavel M, Harlos K, Melillo B, Comer E, Gonse A, Parvez S, Mitasev B, Fang FG, Schreiber SL, Sharma A. Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines. Nature Communications. 12: 343. PMID 33436639 DOI: 10.1038/s41467-020-20478-5  0.75
2020 Zou Y, Henry WS, Ricq EL, Graham ET, Phadnis VV, Maretich P, Paradkar S, Boehnke N, Deik AA, Reinhardt F, Eaton JK, Ferguson B, Wang W, Fairman J, Keys HR, ... ... Schreiber SL, et al. Plasticity of ether lipids promotes ferroptosis susceptibility and evasion. Nature. PMID 32939090 DOI: 10.1038/S41586-020-2732-8  0.731
2020 Eaton JK, Furst L, Cai LL, Viswanathan VS, Schreiber SL. Structure-activity relationships of GPX4 inhibitor warheads. Bioorganic & Medicinal Chemistry Letters. 127538. PMID 32920142 DOI: 10.1016/J.Bmcl.2020.127538  0.354
2020 Siriwardena SU, Munkanatta Godage DNP, Shoba VM, Lai S, Shi M, Wu P, Chaudhary SK, Schreiber SL, Choudhary A. Phosphorylation-Inducing Chimeric Small Molecules. Journal of the American Chemical Society. PMID 32787262 DOI: 10.1021/Jacs.0C05537  0.8
2020 Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, ... ... Schreiber SL, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. PMID 32730809 DOI: 10.1016/J.Cell.2020.07.001  0.369
2020 Howard TP, Oberlick EM, Rees MG, Arnoff TE, Pham MN, Brenan L, DoCarmo M, Hong AL, Kugener G, Chou HC, Drosos Y, Mathias KM, Ramos P, Seashore-Ludlow B, Giacomelli AO, ... ... Schreiber SL, et al. Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32631955 DOI: 10.1158/1078-0432.Ccr-19-2717  0.304
2020 Zou Y, Schreiber SL. Progress in Understanding Ferroptosis and Challenges in Its Targeting for Therapeutic Benefit. Cell Chemical Biology. 27: 463-471. PMID 32302583 DOI: 10.1016/J.Chembiol.2020.03.015  0.304
2020 Westphal MV, Hudson L, Mason JW, Pradeilles J, Zecri FJ, Briner K, Schreiber SL. Water-compatible Cycloadditions of Oligonucleotide-conjugated Strained Allenes for DNA-encoded Library Synthesis. Journal of the American Chemical Society. PMID 32267148 DOI: 10.1021/Jacs.9B13186  0.318
2020 Eaton JK, Furst L, Ruberto RA, Moosmayer D, Hilpmann A, Ryan MJ, Zimmermann K, Cai LL, Niehues M, Badock V, Kramm A, Chen S, Hillig RC, Clemons PA, Gradl S, ... ... Schreiber SL, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nature Chemical Biology. PMID 32231343 DOI: 10.1038/S41589-020-0501-5  0.625
2020 Vallabh SM, Minikel EV, Schreiber SL, Lander ES. Towards a treatment for genetic prion disease: trials and biomarkers. The Lancet. Neurology. 19: 361-368. PMID 32199098 DOI: 10.1016/S1474-4422(19)30403-X  0.429
2020 Gerry CJ, Schreiber SL. Unifying principles of bifunctional, proximity-inducing small molecules. Nature Chemical Biology. 16: 369-378. PMID 32198490 DOI: 10.1038/S41589-020-0469-1  0.396
2020 Zou Y, Li H, Graham ET, Deik AA, Eaton JK, Wang W, Sandoval-Gomez G, Clish CB, Doench JG, Schreiber SL. Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nature Chemical Biology. 16: 302-309. PMID 32080622 DOI: 10.1038/S41589-020-0472-6  0.647
2020 Xia G, Zhuang Z, Liu LY, Schreiber SL, Melillo B, Yu JQ. Ligand-Enabled β-Methylene C(sp3)-H Arylation of Masked Aliphatic Alcohols. Angewandte Chemie (International Ed. in English). PMID 32050036 DOI: 10.1002/Anie.202000632  0.769
2020 Michalska K, Chang C, Maltseva NI, Jedrzejczak R, Robertson GT, Gusovsky F, McCarren P, Schreiber SL, Nag PP, Joachimiak A. Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase. Protein Science : a Publication of the Protein Society. PMID 31930594 DOI: 10.1002/Pro.3825  0.337
2019 Eaton JK, Ruberto RA, Kramm A, Viswanathan VS, Schreiber SL. Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently. Journal of the American Chemical Society. PMID 31841309 DOI: 10.1021/Jacs.9B10769  0.381
2019 Lewis TA, de Waal L, Wu X, Youngsaye W, Wengner A, Kopitz C, Lange M, Gradl S, Ellermann M, Lienau P, Schreiber SL, Greulich H, Meyerson M. Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing. Acs Medicinal Chemistry Letters. 10: 1537-1542. PMID 31749907 DOI: 10.1021/Acsmedchemlett.9B00360  0.51
2019 To TL, Cuadros AM, Shah H, Hung WHW, Li Y, Kim SH, Rubin DHF, Boe RH, Rath S, Eaton JK, Piccioni F, Goodale A, Kalani Z, Doench JG, Root DE, ... Schreiber SL, et al. A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering. Cell. 179: 1222-1238.e17. PMID 31730859 DOI: 10.1016/J.Cell.2019.10.032  0.303
2019 Gerry CJ, Schreiber SL. Recent achievements and current trajectories of diversity-oriented synthesis. Current Opinion in Chemical Biology. 56: 1-9. PMID 31622927 DOI: 10.1016/J.Cbpa.2019.08.008  0.355
2019 Oberlick EM, Rees MG, Seashore-Ludlow B, Vazquez F, Nelson GM, Dharia NV, Weir BA, Tsherniak A, Ghandi M, Krill-Burger JM, Meyers RM, Wang X, Montgomery P, Root DE, Bieber JM, ... ... Schreiber SL, et al. Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors. Cell Reports. 28: 2331-2344.e8. PMID 31461650 DOI: 10.1016/J.Celrep.2019.07.021  0.762
2019 Li H, Ericsson M, Rabasha B, Budnik B, Chan SH, Freinkman E, Lewis CA, Doench JG, Wagner BK, Garraway LA, Schreiber SL. 6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels. Cell Chemical Biology. PMID 31204288 DOI: 10.1016/J.Chembiol.2019.05.006  0.599
2019 Gerry CJ, Wawer MJ, Clemons PA, Schreiber SL. DNA barcoding a complete matrix of stereoisomeric small molecules. Journal of the American Chemical Society. PMID 31184885 DOI: 10.1021/Jacs.9B01203  0.616
2019 Shang M, Feu KS, Vantourout JC, Barton LM, Osswald HL, Kato N, Gagaring K, McNamara CW, Chen G, Hu L, Ni S, Fernández-Canelas P, Chen M, Merchant RR, Qin T, ... Schreiber SL, et al. Modular, stereocontrolled C-H/C-C activation of alkyl carboxylic acids. Proceedings of the National Academy of Sciences of the United States of America. PMID 30996125 DOI: 10.1073/Pnas.1903048116  0.774
2019 Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dančík V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, ... ... Schreiber SL, et al. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nature Communications. 10: 1617. PMID 30962421 DOI: 10.1038/S41467-019-09277-9  0.797
2019 Hong AL, Tseng YY, Wala JA, Kim WJ, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, Yang X, Tillgren M, Ghandi M, Sayeed A, Deasy R, ... ... Schreiber SL, et al. Renal medullary carcinomas depend upon loss and are sensitive to proteasome inhibition. Elife. 8. PMID 30860482 DOI: 10.7554/Elife.44161  0.649
2019 Sharifnia T, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, ... ... Schreiber SL, et al. Small-molecule targeting of brachyury transcription factor addiction in chordoma. Nature Medicine. PMID 30664779 DOI: 10.1038/S41591-018-0312-3  0.795
2019 Hong AL, Tseng Y, Wala JA, Kim W, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, Yang X, Tillgren M, Ghandi M, Sayeed A, Deasy R, ... ... Schreiber SL, et al. Author response: Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition Elife. DOI: 10.7554/Elife.44161.051  0.626
2019 Schreiber SL. Abstract SY42-01: Chemical biology-based approach to understanding and overcoming resistance of cancers to therapies Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Sy42-01  0.304
2018 Melillo B, Zoller J, Hua BK, Verho O, Borghs J, Nelson SD, Maetani M, Wawer MJ, Clemons PA, Schreiber SL. Synergistic effects of stereochemistry and appendages on the performance diversity of a collection of synthetic compounds. Journal of the American Chemical Society. PMID 30133283 DOI: 10.1021/Jacs.8B07319  0.814
2018 Radke JB, Carey KL, Shaw S, Metkar S, Mulrooney C, Gale JP, Bittker JA, Hilgraf R, Comer E, Schreiber SL, Virgin HW, Perez JR, Sibley LD. High throughput screen identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth. Acs Infectious Diseases. PMID 30058798 DOI: 10.1021/Acsinfecdis.8B00135  0.308
2018 Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW. Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. PMID 30046103 DOI: 10.1038/S41586-018-0284-Y  0.627
2018 Alvarez MJ, Subramaniam PS, Tang LH, Grunn A, Aburi M, Rieckhof G, Komissarova EV, Hagan EA, Bodei L, Clemons PA, Dela Cruz FS, Dhall D, Diolaiti D, Fraker DA, Ghavami A, ... ... Schreiber S, et al. A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors. Nature Genetics. PMID 29915428 DOI: 10.1038/S41588-018-0138-4  0.762
2018 Santos-Rosa H, Schneider R, Bernstein BE, Karabetsou N, Morillon A, Weise C, Schreiber SL, Mellor J, Kouzarides T. Methylation of Histone H3 K4 Mediates Association of the Isw1p ATPase with Chromatin. Molecular Cell. 70: 983. PMID 29883612 DOI: 10.1016/j.molcel.2018.05.012  0.444
2018 Basu A, Mitra R, Liu H, Schreiber SL, Clemons PA. RWEN: Response-Weighted Elastic Net For Prediction of Chemosensitivity of Cancer Cell Lines. Bioinformatics (Oxford, England). PMID 29688307 DOI: 10.1093/Bioinformatics/Bty199  0.594
2018 Gerry CJ, Schreiber SL. Chemical probes and drug leads from advances in synthetic planning and methodology. Nature Reviews. Drug Discovery. 17: 333-352. PMID 29651105 DOI: 10.1038/Nrd.2018.53  0.376
2018 Liu H, Schreiber SL, Stockwell BR. Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy. Biochemistry. PMID 29584411 DOI: 10.1021/Acs.Biochem.8B00307  0.519
2018 Ferrer-Luna R, Ramkissoon SH, Ramkissoon LA, Pellton K, Schumacher SE, Lamothe R, Cheah JH, Haidar S, Kang YJ, Knoff DS, Maire CL, Olausson KH, Song W, Idbaih A, Rinne ML, ... ... Schreiber SL, et al. Abstract B077: Comprehensive molecular characterization and high-throughput chemical screening identifies genetic dependencies and molecular vulnerabilities in glioblastoma cell line models Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-B077  0.708
2017 Aksoy BA, Dancík V, Smith K, Mazerik JN, Ji Z, Gross B, Nikolova O, Jaber N, Califano A, Schreiber SL, Gerhard DS, Hermida LC, Jagu S, Sander C, Floratos A, et al. CTD2 Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network. Database : the Journal of Biological Databases and Curation. 2017. PMID 29220450 DOI: 10.1093/Database/Bax054  0.56
2017 Subramanian A, Narayan R, Corsello SM, Peck DD, Natoli TE, Lu X, Gould J, Davis JF, Tubelli AA, Asiedu JK, Lahr DL, Hirschman JE, Liu Z, Donahue M, Julian B, ... ... Schreiber SL, et al. A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. Cell. 171: 1437-1452.e17. PMID 29195078 DOI: 10.1016/J.Cell.2017.10.049  0.774
2017 Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, Galeas J, Dhruv HD, Berens ME, Schreiber SL, McCormick F, McManus MT. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature. PMID 29088702 DOI: 10.1038/Nature24297  0.306
2017 Leshchiner ES, Rush JS, Durney MA, Cao Z, Dančík V, Chittick B, Wu H, Petrone A, Bittker JA, Phillips A, Perez JR, Shamji AF, Kaushik VK, Daly MJ, Graham DB, ... Schreiber SL, et al. Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease. Proceedings of the National Academy of Sciences of the United States of America. 114: 11392-11397. PMID 29073062 DOI: 10.1073/Pnas.1705748114  0.791
2017 Verho O, Maetani M, Melillo B, Zoller J, Schreiber SL. Stereospecific Palladium-Catalyzed C-H Arylation of Pyroglutamic Acid Derivatives at the C3 Position Enabled by 8-Aminoquinoline as a Directing Group. Organic Letters. PMID 28809506 DOI: 10.1021/Acs.Orglett.7B01776  0.771
2017 Johannessen L, Sundberg TB, O'Connell DJ, Kolde R, Berstler J, Billings KJ, Khor B, Seashore-Ludlow B, Fassl A, Russell CN, Latorre IJ, Jiang B, Graham DB, Perez JR, Sicinski P, ... ... Schreiber SL, et al. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nature Chemical Biology. PMID 28805801 DOI: 10.1038/Nchembio.2458  0.644
2017 Maetani M, Zoller J, Melillo B, Verho O, Kato N, Pu J, Comer E, Schreiber SL. Synthesis of a bicyclic azetidine with in vivo antimalarial activity enabled by stereospecific, directed C(sp(3))-H arylation. Journal of the American Chemical Society. PMID 28732448 DOI: 10.1021/Jacs.7B06994  0.79
2017 Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, ... ... Schreiber SL, et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. PMID 28678785 DOI: 10.1038/Nature23007  0.785
2017 Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, et al. A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nature Chemical Biology. PMID 28671682 DOI: 10.1038/Nchembio.2420  0.805
2017 Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, ... ... Schreiber SL, et al. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. Cell. 170: 199-212.e20. PMID 28666119 DOI: 10.1016/J.Cell.2017.06.011  0.638
2017 Maetani M, Kato N, Jabor VAP, Calil FA, Nonato MC, Scherer CA, Schreiber SL. Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase. Acs Medicinal Chemistry Letters. 8: 438-442. PMID 28435533 DOI: 10.1021/Acsmedchemlett.7B00030  0.745
2017 Bray MA, Gustafsdottir SM, Ljosa V, Singh S, Sokolnicki KL, Bittker JA, Bodycombe NE, Dancík V, Hasaka TP, Hon CS, Kemp MM, Li K, Walpita D, Wawer MJ, Golub TR, ... Schreiber SL, et al. A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay. Gigascience. PMID 28327978 DOI: 10.1093/Gigascience/Giw014  0.787
2017 Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, ... ... Schreiber SL, et al. US immigration order strikes against biotech. Nature Biotechnology. 35: 204-206. PMID 28267733 DOI: 10.1038/Nbt.3824  0.692
2017 Hong AL, Tseng Y, Kynnap BD, Doshi MB, Sandoval G, Oh C, Sayeed A, Shubhroz G, Church AJ, Keskula P, Peng A, Clemons PA, Tsherniak A, Vazquez F, Rodriguez-Galindo C, ... ... Schreiber SL, et al. Abstract B17: Identification of Druggable Targets through Functional Multi-Omics in Renal Medullary Carcinoma Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-B17  0.598
2017 Tseng Y(, Hong A, Gill S, Keskula P, Raghavan S, Cheah J, Tsherniak A, Vazquez F, Alkhairy S, Peng A, Sayeed A, Deasy R, Ronning P, Kantoff P, Garraway L, ... ... Schreiber S, et al. Abstract A02: Expanding tumor chemical-genetic interaction map using next-generation cancer models Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-A02  0.697
2017 Ferrer-Luna R, Ramkissoon SH, Olausson KH, Ramkissoon LA, Schumacher S, Lamothe R, Cheah JH, Pellton K, Haidar S, Kang YJ, Paolella BR, Maire C, Song W, Meng A, Idbaih A, ... ... Schreiber SL, et al. Abstract 4974: Pharmacogenomic interactions in glioblastoma cell line models Cancer Research. 77: 4974-4974. DOI: 10.1158/1538-7445.Am2017-4974  0.788
2017 Chattopadhyay S, Huang C, Baryawno N, Severe N, Viswanathan V, Costa C, Scadden D, Schreiber S. Abstract 3026: Targeting GPX4 in tumor-associated stromal cells increases inflammatory-cell infiltration Cancer Research. 77: 3026-3026. DOI: 10.1158/1538-7445.Am2017-3026  0.338
2017 Wu X, Lewis T, Waal Ld, Gao G, Zhang J, Schenone M, Garvie C, Diamond B, Lorrey S, Cherniack A, Corsello S, Burgin A, Golub T, Schreiber S, Meyerson M, et al. Abstract 2028: PDE3A modulation for cancer therapy Cancer Research. 77: 2028-2028. DOI: 10.1158/1538-7445.Am2017-2028  0.42
2017 Tseng Y, Hong A, Keskula P, Gill S, Cheah J, Kryukov G, Tsherniak A, Vazquez F, Cowley G, Alkhairy S, Oh C, Peng A, Deasy R, Sayeed A, Ronning P, ... ... Schreiber S, et al. Abstract 1953: Accelerating prediction of pediatric and rare cancer vulnerabilities using next-generation cancer models Cancer Research. 77: 1953-1953. DOI: 10.1158/1538-7445.Am2017-1953  0.658
2017 Michalska K, Wellington S, Nag PP, Jedrzejczak R, Maltseva NI, Fisher SL, Schreiber SL, Hung DT, Joachimiak A. Structure of Mycobacterium tuberculosis tryptophan synthase: a model system for allosteric inhibition Acta Crystallographica Section a Foundations and Advances. 73: a288-a288. DOI: 10.1107/S0108767317097161  0.77
2017 Joachimiak A, Wellington S, Nag PP, Jedrzejczak R, Maltseva NI, Fisher SL, Schreiber SL, Hung DT, Michalska K. Structural insight into allosteric inhibition of Mycobacterium tuberculosis tryptophan synthase Acta Crystallographica Section a Foundations and Advances. 73: a428-a428. DOI: 10.1107/S0108767317095824  0.772
2016 Speyer G, Mahendra D, Tran HJ, Kiefer J, Schreiber SL, Clemons PA, Dhruv H, Berens M, Kim S. DIFFERENTIAL PATHWAY DEPENDENCY DISCOVERY ASSOCIATED WITH DRUG RESPONSE ACROSS CANCER CELL LINES. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 22: 497-508. PMID 27897001  0.568
2016 Hideshima T, Qi J, Paranal RM, Tang W, Greenberg E, West N, Colling ME, Estiu G, Mazitschek R, Perry JA, Ohguchi H, Cottini F, Mimura N, Görgün G, Tai YT, ... ... Schreiber SL, et al. Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America. PMID 27799547 DOI: 10.1073/Pnas.1608067113  0.646
2016 Law JM, Stark SC, Liu K, Liang NE, Hussain MM, Leiendecker M, Ito D, Verho O, Stern AM, Johnston SE, Zhang YL, Dunn GP, Shamji AF, Schreiber SL. Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1. Acs Medicinal Chemistry Letters. 7: 944-949. PMID 27774134 DOI: 10.1021/Acsmedchemlett.6B00264  0.811
2016 Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, ... ... Schreiber SL, et al. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. PMID 27641501 DOI: 10.1016/J.Cell.2016.08.057  0.605
2016 Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan G, Duffy S, Eckley S, ... ... Schreiber SL, et al. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. PMID 27602946 DOI: 10.1038/Nature19804  0.806
2016 Haftchenary S, Nelson SD, Furst L, Dandapani S, Ferrara SJ, Bošković ŽV, Figueroa Lazú S, Guerrero AM, Serrano JC, Crews DK, Brackeen C, Mowat J, Brumby T, Bauser M, Schreiber SL, et al. Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments. Acs Combinatorial Science. PMID 27518324 DOI: 10.1021/Acscombsci.6B00050  0.771
2016 Gerhard DS, Clemons PA, Shamji AF, Hon C, Wagner BK, Schreiber SL, Krasnitz A, Sordella R, Sander C, Lowe SW, Powers S, Smith K, Aburi M, Iavarone A, Lasorella A, et al. Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance. Molecular Cancer Research : McR. PMID 27401613 DOI: 10.1158/1541-7786.Mcr-16-0090  0.788
2016 Gerry CJ, Hua BK, Wawer MJ, Knowles JP, Nelson SD, Verho O, Dandapani S, Wagner BK, Clemons PA, Booker-Milburn KI, Boskovic ZV, Schreiber SL. Real-Time Biological Annotation of Synthetic Compounds. Journal of the American Chemical Society. PMID 27398798 DOI: 10.1021/Jacs.6B04614  0.808
2016 Hong AL, Tseng YY, Cowley GS, Jonas O, Cheah JH, Kynnap BD, Doshi MB, Oh C, Meyer SC, Church AJ, Gill S, Bielski CM, Keskula P, Imamovic A, Howell S, ... ... Schreiber SL, et al. Integrated genetic and pharmacologic interrogation of rare cancers. Nature Communications. 7: 11987. PMID 27329820 DOI: 10.1038/Ncomms11987  0.797
2016 Swann J, Corey V, Scherer CA, Kato N, Comer E, Maetani M, Antonova-Koch Y, Reimer C, Gagaring K, Ibanez M, Plouffe D, Zeeman AM, Kocken CH, McNamara CW, Schreiber SL, et al. High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria. Acs Infectious Diseases. 2: 281-293. PMID 27275010 DOI: 10.1021/Acsinfecdis.5B00143  0.757
2016 Wimalasena NK, Le VQ, Wimalasena K, Schreiber SL, Karmacharya R. Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent. Acs Chemical Neuroscience. PMID 27270122 DOI: 10.1021/Acschemneuro.6B00076  0.8
2016 Sundberg TB, Liang Y, Wu H, Choi HG, Kim ND, Sim T, Johannessen L, Petrone A, Khor B, Graham DB, Latorre IJ, Phillips AJ, Schreiber SL, Perez J, Shamji AF, et al. Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function In Vivo. Acs Chemical Biology. PMID 27224444 DOI: 10.1021/Acschembio.6B00217  0.777
2016 Wagner FF, Bishop JA, Gale JP, Shi X, Walk M, Ketterman J, Patnaik D, Barker D, Walpita D, Campbell AJ, Nguyen S, Lewis M, Ross L, Weiwer M, An WF, ... ... Schreiber SL, et al. Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-wide Selectivity and their Functional Effects. Acs Chemical Biology. PMID 27128528 DOI: 10.1021/Acschembio.6B00306  0.781
2016 Yard BD, Adams DJ, Chie EK, Tamayo P, Battaglia JS, Gopal P, Rogacki K, Pearson BE, Phillips J, Raymond DP, Pennell NA, Almeida F, Cheah JH, Clemons PA, Shamji A, ... ... Schreiber SL, et al. A genetic basis for the variation in the vulnerability of cancer to DNA damage. Nature Communications. 7: 11428. PMID 27109210 DOI: 10.1038/Ncomms11428  0.722
2016 Boskovic ZV, Kemp MM, Freedy AM, Viswanathan VS, Pop MS, Fuller JH, Martinez NM, Figuero Lazu SO, Hong JA, Lewis TA, Calarese D, Love JD, Vetere A, Almo SC, Schreiber SL, et al. Inhibition of zinc-dependent histone deacetylases with a chemically triggered electrophile. Acs Chemical Biology. PMID 27064299 DOI: 10.1021/Acschembio.6B00012  0.804
2016 Hanaford AR, Archer TC, Price A, Kahlert UD, Maciaczyk J, Nikkhah G, Kim JW, Ehrenberger T, Clemons PA, Dančík V, Seashore-Ludlow B, Viswanathan V, Stewart ML, Rees M, Shamji AF, ... Schreiber SL, et al. DiSCoVERing innovative therapies for rare tumors: combining genetically accurate disease models with in silico analysis to identify novel therapeutic targets. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27012813 DOI: 10.1158/1078-0432.Ccr-15-3011  0.738
2016 Wagner BK, Schreiber SL. The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods. Cell Chemical Biology. 23: 3-9. PMID 26933731 DOI: 10.1016/J.Chembiol.2015.11.008  0.58
2016 Yu C, Mannan AM, Yvone GM, Ross KN, Zhang YL, Marton MA, Taylor BR, Crenshaw A, Gould JZ, Tamayo P, Weir BA, Tsherniak A, Wong B, Garraway LA, Shamji AF, ... ... Schreiber SL, et al. High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines. Nature Biotechnology. PMID 26928769 DOI: 10.1038/Nbt.3460  0.664
2016 Hartland K, Pu J, Palmer M, Dandapani S, Moquist PN, Munoz B, DiDone L, Schreiber SL, Krysan DJ. High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling. Acs Infectious Diseases. 2: 93-102. PMID 26807437 DOI: 10.1021/Acsinfecdis.5B00111  0.385
2016 Huynh MA, Maire CL, Abazeed M, Lam FC, Adams D, Pelton K, Pinnell N, Knoff DC, Korideck H, Hummelen PV, Thorner A, Wen PY, Ligon A, Floyd SR, Schreiber SL, et al. Functional profiling of a glioblastoma (GBM) patient-derived cell line (PDCL) panel to identify cell-intrinsic differential radiation response. Journal of Clinical Oncology. 34: 2069-2069. DOI: 10.1200/Jco.2016.34.15_Suppl.2069  0.463
2016 Hong AL, Tseng Y, Cowley G, Jonas O, Cheah J, Doshi M, Kynnap B, Oy C, Keskula P, Kryukov G, Cima M, Langer R, Schreiber S, Root D, Boehm J, et al. Abstract PR04: Integration of CRISPR-Cas9, RNAi and pharmacologic screens identify actionable targets in a rare cancer Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-Pr04  0.441
2016 Tseng Y, Keskula P, Hong AL, Gill S, Cheah JH, Kryukov GV, Tsherniak A, Vazquez F, Cowley G, Oh C, Peng A, Sayeed A, Deasy R, Ronning P, Kantoff P, ... ... Schreiber SL, et al. Abstract B26: Accelerating prediction of tumor vulnerabilities using next-generation cancer models Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B26  0.693
2016 Raghavan S, Gill S, Aguirre AJ, Tseng YM, Peng A, Keskula P, Wu X, Oh C, Cheah J, Kryukov G, Sicinska E, Wolpin BM, Kulke MH, Fuchs CS, Clemons P, ... ... Schreiber S, et al. Abstract B13: Human pancreatic cancer organoids for functional dependency profiling Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B13  0.701
2016 Hong AL, Cowley GS, Tseng Y, Cheah JH, Jonas O, Doshi MB, Kynnap BD, Oh C, Meyer S, Clemons P, Burger M, Vazquez F, Weir B, Kryukov GV, Church A, ... ... Schreiber SL, et al. Abstract B38: Developing a functional genomics platform to interrogate rare pediatric cancers Cancer Research. 76. DOI: 10.1158/1538-7445.Pedca15-B38  0.656
2016 Tseng Y, Hong A, Keskula P, Gill S, Cheah J, Kryukov G, Tsherniak A, Vazquez F, Cowley G, Oh C, Peng A, Sayeed A, Deasy R, Ronning P, Kantoff P, ... ... Schreiber S, et al. Abstract 4367: Accelerating prediction of tumor vulnerabilities using next-generation cancer models Cancer Research. 76: 4367-4367. DOI: 10.1158/1538-7445.Am2016-4367  0.7
2016 Hanaford AR, Archer TC, Price A, Kahlert U, Maciaczyk J, Guido N, Kim W, Ehrenberger T, Clemons P, Dancik V, Seashore-Ludlow B, Viswanathan V, Stewart M, Rees M, Shamji A, ... ... Schreiber S, et al. Abstract 2476: DiSCoVERing innovative therapies for rare tumors: Combining genetically accurate disease models with advanced in silico analysis to identify novel therapeutic targets Cancer Research. 76: 2476-2476. DOI: 10.1158/1538-7445.Am2016-2476  0.563
2016 Speyer G, Dhruv H, Kiefer J, Schreiber S, Clemons P, Berens ME, Kim S. Abstract 1520: Identifying differential dependency networks accounting for response to NEDD8-inhibitor in large-scale cancer cell line data Cancer Research. 76: 1520-1520. DOI: 10.1158/1538-7445.Am2016-1520  0.617
2016 Hanaford A, Archer T, Price A, Kahlert U, Maciaczyk J, Nikkhah G, Kim JW, Ehrenberger T, Clemons PA, Dančík V, Seashore-Ludlow B, Viswanathan V, Stewart ML, Rees MG, Shamji A, ... Schreiber S, et al. MB-103DiSCoVERing INNOVATIVE THERAPIES: COMBINING GENETICALLY ACCURATE DISEASE MODELS OF MEDULLOBLASTOMA WITH ADVANCED IN SILICO ANALYSIS TO IDENTIFY NOVEL THERAPEUTIC TARGETS Neuro-Oncology. 18: iii120.3-iii120. DOI: 10.1093/Neuonc/Now076.98  0.724
2016 Zhang Z, Boskovic Z, Hussain M, Hu W, Inouye C, Koehler A, Schreiber S, Tjian R. Chemical Perturbation of an Intrinsically Disordered Region of TFIID Distinguishes de novo Transcription Initiation from Reinitiation Biophysical Journal. 110: 557a. DOI: 10.1016/J.Bpj.2015.11.2980  0.794
2015 Plouffe DM, Wree M, Du AY, Meister S, Li F, Patra K, Lubar A, Okitsu SL, Flannery EL, Kato N, Tanaseichuk O, Comer E, Zhou B, Kuhen K, Zhou Y, ... ... Schreiber SL, et al. High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission. Cell Host & Microbe. PMID 26749441 DOI: 10.1016/J.Chom.2015.12.001  0.308
2015 Rees MG, Seashore-Ludlow B, Cheah JH, Adams DJ, Price EV, Gill S, Javaid S, Coletti ME, Jones VL, Bodycombe NE, Soule CK, Alexander B, Li A, Montgomery P, Kotz JD, ... ... Schreiber SL, et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nature Chemical Biology. PMID 26656090 DOI: 10.1038/Nchembio.1986  0.815
2015 de Waal L, Lewis TA, Rees MG, Tsherniak A, Wu X, Choi PS, Gechijian L, Hartigan C, Faloon PW, Hickey MJ, Tolliday N, Carr SA, Clemons PA, Munoz B, Wagner BK, ... ... Schreiber SL, et al. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nature Chemical Biology. PMID 26656089 DOI: 10.1038/Nchembio.1984  0.807
2015 Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, ... ... Schreiber SL, et al. Corrigendum: The promise and peril of chemical probes. Nature Chemical Biology. 11: 887. PMID 26485080 DOI: 10.1038/Nchembio1115-887C  0.507
2015 Seashore-Ludlow B, Rees MG, Cheah JH, Cokol M, Price EV, Coletti ME, Jones V, Bodycombe NE, Soule CK, Gould J, Alexander B, Li A, Montgomery P, Wawer MJ, Kuru N, ... ... Schreiber SL, et al. Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset. Cancer Discovery. 5: 1210-23. PMID 26482930 DOI: 10.1158/2159-8290.Cd-15-0235  0.784
2015 Dockendorff C, Faloon PW, Yu M, Youngsaye W, Penman M, Nieland TJ, Nag PP, Lewis TA, Pu J, Bennion M, Negri J, Paterson C, Lam G, Dandapani S, Perez JR, ... ... Schreiber SL, et al. Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport. Acs Medicinal Chemistry Letters. 6: 375-380. PMID 26478787 DOI: 10.1021/Ml500154Q  0.343
2015 Nühs A, De Rycker M, Manthri S, Comer E, Scherer CA, Schreiber SL, Ioset JR, Gray DW. Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity. Plos Neglected Tropical Diseases. 9: e0004094. PMID 26407168 DOI: 10.1371/Journal.Pntd.0004094  0.341
2015 Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW. Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. PMID 26375002 DOI: 10.1038/Nature15370  0.639
2015 Zhang Z, Boskovic Z, Hussain MM, Hu W, Inouye C, Kim HJ, Abole AK, Doud MK, Lewis TA, Koehler AN, Schreiber SL, Tjian R. Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation. Elife. 4. PMID 26314865 DOI: 10.7554/Elife.07777  0.764
2015 Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, ... ... Schreiber SL, et al. The promise and peril of chemical probes. Nature Chemical Biology. 11: 536-41. PMID 26196764 DOI: 10.1038/Nchembio.1867  0.492
2015 Kuo SY, Castoreno AB, Aldrich LN, Lassen KG, Goel G, Dan?ík V, Kuballa P, Latorre I, Conway KL, Sarkar S, Maetzel D, Jaenisch R, Clemons PA, Schreiber SL, Shamji AF, et al. Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics. Proceedings of the National Academy of Sciences of the United States of America. PMID 26195741 DOI: 10.1073/Pnas.1512289112  0.749
2015 Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/J.Cell.2015.05.023  0.785
2015 Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dan?ík V, Ciarlo C, Paulk J, ... ... Schreiber SL, et al. Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling. Journal of the American Chemical Society. 137: 7929-34. PMID 26042473 DOI: 10.1021/Jacs.5B04284  0.809
2015 Khor B, Gagnon JD, Goel G, Roche MI, Conway KL, Tran K, Aldrich LN, Sundberg TB, Paterson AM, Mordecai S, Dombkowski D, Schirmer M, Tan PH, Bhan AK, Roychoudhuri R, ... ... Schreiber SL, et al. The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells. Elife. 4. PMID 25998054 DOI: 10.7554/Elife.05920  0.623
2015 Stewart ML, Tamayo P, Wilson AJ, Wang S, Chang YM, Kim JW, Khabele D, Shamji AF, Schreiber SL. KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine. Cancer Research. 75: 2897-906. PMID 25968887 DOI: 10.1158/0008-5472.Can-14-2860  0.658
2015 Dockendorff C, Faloon PW, Germain A, Yu M, Youngsaye W, Nag PP, Bennion M, Penman M, Nieland TJ, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M. Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Bioorganic & Medicinal Chemistry Letters. 25: 2594-8. PMID 25958245 DOI: 10.1016/J.Bmcl.2015.03.074  0.636
2015 Dockendorff C, Faloon PW, Pu J, Yu M, Johnston S, Bennion M, Penman M, Nieland TJ, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M. Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Bioorganic & Medicinal Chemistry Letters. 25: 2100-5. PMID 25900219 DOI: 10.1016/J.Bmcl.2015.03.073  0.382
2015 Aldrich LN, Kuo SY, Castoreno AB, Goel G, Kuballa P, Rees MG, Seashore-Ludlow BA, Cheah JH, Latorre IJ, Schreiber SL, Shamji AF, Xavier RJ. Discovery of a Small-Molecule Probe for V-ATPase Function. Journal of the American Chemical Society. 137: 5563-8. PMID 25860544 DOI: 10.1021/Jacs.5B02150  0.68
2015 Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, ... ... Schreiber SL, et al. Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Reports. PMID 25660025 DOI: 10.1016/J.Celrep.2015.01.017  0.809
2015 Scully SS, Zheng SL, Wagner BK, Schreiber SL. Synthesis of oxazocenones via gold(I)-catalyzed 8-endo-dig hydroalkoxylation of alkynamides. Organic Letters. 17: 418-21. PMID 25569027 DOI: 10.1021/Ol503273V  0.736
2015 Park SW, Casalena DE, Wilson DJ, Dai R, Nag PP, Liu F, Boyce JP, Bittker JA, Schreiber SL, Finzel BC, Schnappinger D, Aldrich CC. Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis. Chemistry & Biology. 22: 76-86. PMID 25556942 DOI: 10.1016/J.Chembiol.2014.11.012  0.391
2015 Iaconelli J, Huang JH, Berkovitch SS, Chattopadhyay S, Mazitschek R, Schreiber SL, Haggarty SJ, Karmacharya R. HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells. Acs Chemical Biology. 10: 883-90. PMID 25546293 DOI: 10.1021/Cb500838R  0.541
2015 Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, ... Schreiber SL, et al. Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discovery. 5: 154-67. PMID 25501949 DOI: 10.1158/2159-8290.Cd-14-0552  0.727
2015 Howe EA, de Souza A, Lahr DL, Chatwin S, Montgomery P, Alexander BR, Nguyen DT, Cruz Y, Stonich DA, Walzer G, Rose JT, Picard SC, Liu Z, Rose JN, Xiang X, ... ... Schreiber SL, et al. BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types. Nucleic Acids Research. 43: D1163-70. PMID 25477388 DOI: 10.1093/Nar/Gku1244  0.618
2015 Lukens AK, Heidebrecht RW, Mulrooney C, Beaudoin JA, Comer E, Duvall JR, Fitzgerald ME, Masi D, Galinsky K, Scherer CA, Palmer M, Munoz B, Foley M, Schreiber SL, Wiegand RC, et al. Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors. The Journal of Infectious Diseases. 211: 1097-103. PMID 25336726 DOI: 10.1093/Infdis/Jiu565  0.358
2015 Khor B, Gagnon JD, Goel G, Roche MI, Conway KL, Tran K, Aldrich LN, Sundberg TB, Paterson AM, Mordecai S, Dombkowski D, Schirmer M, Tan PH, Bhan AK, Roychoudhuri R, ... ... Schreiber SL, et al. Author response: The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells Elife. DOI: 10.7554/Elife.05920.028  0.621
2015 Zhou AY, Martins MM, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, ... Schreiber SL, et al. Abstract B48: Identification of novel drug interactions with MYC via a quantitative chemical-genetic interaction map Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-B48  0.743
2015 Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, ... Schreiber S, et al. Abstract PR15: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-Pr15  0.749
2015 Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, ... Schreiber S, et al. Abstract PR07: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-Pr07  0.749
2015 Abazeed M, Yard B, Adams D, Tamayo P, Hearn J, Chie EK, Schreiber S, Meyerson M, Peacock C, Hammerman P. Abstract 3315: Functional genomic profiling of lung adenocarcinoma identifies BRAF mutations as novel therapeutic targets Cancer Research. 75: 3315-3315. DOI: 10.1158/1538-7445.Am2015-3315  0.464
2015 Waal Ld, Lewis TA, Rees MG, Tsherniak A, Wu X, Choi PS, Gechijian L, Hartigan C, Faloon PW, Hickey MJ, Tolliday N, Carr SA, Clemons PA, Munoz B, Wagner BK, ... ... Schreiber SL, et al. Abstract C136: Identification of selective cancer cytotoxic modulators of phosphodiesterase 3a by predictive chemogenomics Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C136  0.8
2015 Abazeed M, Adams D, Hammerman P, Tamayo P, Yard B, Meyerson M, Schreiber S. Systematic Investigation of Genetic Vulnerabilities Across Cancer Cell Lines Reveals Lineage Specific Radiotherapeutic Determinants International Journal of Radiation Oncology*Biology*Physics. 93: S143-S144. DOI: 10.1016/J.Ijrobp.2015.07.340  0.46
2014 Playa H, Lewis TA, Ting A, Suh BC, Muñoz B, Matuza R, Passer BJ, Schreiber SL, Buolamwini JK. Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2). Bioorganic & Medicinal Chemistry Letters. 24: 5801-4. PMID 25454272 DOI: 10.1016/J.Bmcl.2014.10.026  0.376
2014 Chan CT, Qi J, Smith W, Paranol R, Mazitschek R, West N, Reeves R, Chiosis G, Schreiber SL, Bradner JE, Paulmurugan R, Gambhir SS. Syntheses and discovery of a novel class of cinnamic hydroxamates as histone deacetylase inhibitors by multimodality molecular imaging in living subjects. Cancer Research. 74: 7475-86. PMID 25320008 DOI: 10.1158/0008-5472.Can-14-0197  0.543
2014 Sundberg TB, Xavier RJ, Schreiber SL, Shamji AF. Small-molecule control of cytokine function: new opportunities for treating immune disorders. Current Opinion in Chemical Biology. 23: 23-30. PMID 25222143 DOI: 10.1016/J.Cbpa.2014.08.013  0.671
2014 Comer E, Beaudoin JA, Kato N, Fitzgerald ME, Heidebrecht RW, Lee Md, Masi D, Mercier M, Mulrooney C, Muncipinto G, Rowley A, Crespo-Llado K, Serrano AE, Lukens AK, Wiegand RC, ... ... Schreiber SL, et al. Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents. Journal of Medicinal Chemistry. 57: 8496-502. PMID 25211597 DOI: 10.1021/Jm500994N  0.363
2014 Sundberg TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B, Gagnon J, O'Connell DJ, Narayan K, Dan?ík V, Perez JR, Reinecker HC, Gray NS, Schreiber SL, et al. Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 12468-73. PMID 25114223 DOI: 10.1073/Pnas.1412308111  0.642
2014 Adams DJ, Ito D, Rees MG, Seashore-Ludlow B, Puyang X, Ramos AH, Cheah JH, Clemons PA, Warmuth M, Zhu P, Shamji AF, Schreiber SL. NAMPT is the cellular target of STF-31-like small-molecule probes. Acs Chemical Biology. 9: 2247-54. PMID 25058389 DOI: 10.1021/Cb500347P  0.765
2014 Wawer MJ, Li K, Gustafsdottir SM, Ljosa V, Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E, Taylor B, Grant GB, Hon CS, Duvall JR, Wilson JA, ... ... Schreiber SL, et al. Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling. Proceedings of the National Academy of Sciences of the United States of America. 111: 10911-6. PMID 25024206 DOI: 10.1073/Pnas.1410933111  0.814
2014 Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, ... ... Schreiber SL, et al. Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease. Acs Medicinal Chemistry Letters. 5: 149-53. PMID 24900788 DOI: 10.1021/Ml400403U  0.601
2014 Wurst JM, Drake EJ, Theriault JR, Jewett IT, VerPlank L, Perez JR, Dandapani S, Palmer M, Moskowitz SM, Schreiber SL, Munoz B, Gulick AM. Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine. Acs Chemical Biology. 9: 1536-44. PMID 24824984 DOI: 10.1021/Cb5001586  0.328
2014 Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, ... ... Schreiber SL, et al. Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Proceedings of the National Academy of Sciences of the United States of America. 111: 7741-6. PMID 24821797 DOI: 10.1073/Pnas.1407001111  0.639
2014 Choudhary A, Hu He K, Mertins P, Udeshi ND, Dan?ík V, Fomina-Yadlin D, Kubicek S, Clemons PA, Schreiber SL, Carr SA, Wagner BK. Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming. Plos One. 9: e95194. PMID 24759943 DOI: 10.1371/Journal.Pone.0095194  0.744
2014 Wawer MJ, Jaramillo DE, Dan?ík V, Fass DM, Haggarty SJ, Shamji AF, Wagner BK, Schreiber SL, Clemons PA. Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles. Journal of Biomolecular Screening. 19: 738-748. PMID 24710340 DOI: 10.1177/1087057114530783  0.811
2014 Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR. Regulation of ferroptotic cancer cell death by GPX4. Cell. 156: 317-31. PMID 24439385 DOI: 10.1016/J.Cell.2013.12.010  0.798
2014 Krönke J, Udeshi ND, Narla A, Grauman P, Hurst SN, McConkey M, Svinkina T, Heckl D, Comer E, Li X, Ciarlo C, Hartman E, Munshi N, Schenone M, Schreiber SL, et al. Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science (New York, N.Y.). 343: 301-5. PMID 24292625 DOI: 10.1126/Science.1244851  0.344
2014 Waal LMd, Lewis TA, Gechijian L, Tsherniak A, Youngsaye W, Rees M, Mikse O, Hickey M, Faloon P, Tolliday N, Koehler A, Schenone M, Wong K, Shamji A, Munoz B, ... Schreiber SL, et al. Abstract 4596: An integrated genomic characterization of the target of a small molecule identifies a novel cancer dependency Cancer Research. 74: 4596-4596. DOI: 10.1158/1538-7445.Am2014-4596  0.8
2014 Abazeed M, Adams D, Tamayo P, Meyerson M, Hammerman P, Schreiber S. Abstract 4259: The radiogenomic landscape of cancer Cancer Research. 74: 4259-4259. DOI: 10.1158/1538-7445.Am2014-4259  0.504
2014 Chattopadhyay S, Huang C, Mukherjee S, Yusuf RZ, Viswanathan V, Wittner BS, Gentry J, Shamji A, Ramaswamy S, Scadden DT, Schreiber SL. Abstract 181: Therapeutic approaches to metastasis induced by mesenchymal stem cells in the tumor microenvironment Cancer Research. 74: 181-181. DOI: 10.1158/1538-7445.Am2014-181  0.667
2014 Abazeed M, Adams D, Tamayo P, Yard B, Loeffler J, Suh J, Meyerson M, Hammerman P, Schreiber S. The Radiogenomic Landscape of Cancer International Journal of Radiation Oncology*Biology*Physics. 90: S34. DOI: 10.1016/J.Ijrobp.2014.05.145  0.422
2013 Gustafsdottir SM, Ljosa V, Sokolnicki KL, Anthony Wilson J, Walpita D, Kemp MM, Petri Seiler K, Carrel HA, Golub TR, Schreiber SL, Clemons PA, Carpenter AE, Shamji AF. Multiplex cytological profiling assay to measure diverse cellular states. Plos One. 8: e80999. PMID 24312513 DOI: 10.1371/Journal.Pone.0080999  0.803
2013 Yuan Y, Hartland K, Boskovic Z, Wang Y, Walpita D, Lysy PA, Zhong C, Young DW, Kim YK, Tolliday NJ, Sokal EM, Schreiber SL, Wagner BK. A small-molecule inducer of PDX1 expression identified by high-throughput screening. Chemistry & Biology. 20: 1513-22. PMID 24290880 DOI: 10.1016/J.Chembiol.2013.10.013  0.8
2013 Boskovic ZV, Hussain MM, Adams DJ, Dai M, Schreiber SL. Synthesis of piperlogs and analysis of their effects on cells. Tetrahedron. 69. PMID 24273350 DOI: 10.1016/J.Tet.2013.05.080  0.764
2013 Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ. Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules. Acs Chemical Biology. 8: 2724-33. PMID 24168452 DOI: 10.1021/Cb400352D  0.651
2013 Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, ... ... Schreiber SL, et al. Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nature Chemical Biology. 9: 840-8. PMID 24161946 DOI: 10.1038/Nchembio.1367  0.803
2013 Basu A, Bodycombe NE, Cheah JH, Price EV, Liu K, Schaefer GI, Ebright RY, Stewart ML, Ito D, Wang S, Bracha AL, Liefeld T, Wawer M, Gilbert JC, Wilson AJ, ... ... Schreiber SL, et al. An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules. Cell. 154: 1151-61. PMID 23993102 DOI: 10.1016/J.Cell.2013.08.003  0.8
2013 Abazeed ME, Adams DJ, Hurov KE, Tamayo P, Creighton CJ, Sonkin D, Giacomelli AO, Du C, Fries DF, Wong KK, Mesirov JP, Loeffler JS, Schreiber SL, Hammerman PS, Meyerson M. Integrative radiogenomic profiling of squamous cell lung cancer. Cancer Research. 73: 6289-98. PMID 23980093 DOI: 10.1158/0008-5472.Can-13-1616  0.485
2013 Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, ... ... Schreiber SL, et al. Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. Gastroenterology. 145: 1347-57. PMID 23973919 DOI: 10.1053/J.Gastro.2013.08.035  0.609
2013 Youngsaye W, Hartland CL, Morgan BJ, Ting A, Nag PP, Vincent B, Mosher CA, Bittker JA, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B. ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans. Beilstein Journal of Organic Chemistry. 9: 1501-7. PMID 23946849 DOI: 10.3762/Bjoc.9.171  0.352
2013 Yuan Y, Tang AJ, Castoreno AB, Kuo SY, Wang Q, Kuballa P, Xavier R, Shamji AF, Schreiber SL, Wagner BK. Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death & Disease. 4: e690. PMID 23807219 DOI: 10.1038/cddis.2013.191  0.764
2013 Schaefer GI, Perez JR, Duvall JR, Stanton BZ, Shamji AF, Schreiber SL. Discovery of small-molecule modulators of the Sonic Hedgehog pathway. Journal of the American Chemical Society. 135: 9675-80. PMID 23725514 DOI: 10.1021/Ja400034K  0.696
2013 Hu L, Magesh S, Chen L, Wang L, Lewis TA, Chen Y, Khodier C, Inoyama D, Beamer LJ, Emge TJ, Shen J, Kerrigan JE, Kong AN, Dandapani S, Palmer M, ... Schreiber SL, et al. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorganic & Medicinal Chemistry Letters. 23: 3039-43. PMID 23562243 DOI: 10.1016/J.Bmcl.2013.03.013  0.366
2013 Adams DJ, Boskovic ZV, Theriault JR, Wang AJ, Stern AM, Wagner BK, Shamji AF, Schreiber SL. Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death. Acs Chemical Biology. 8: 923-9. PMID 23477340 DOI: 10.1021/Cb300653V  0.804
2013 Germain AR, Carmody LC, Nag PP, Morgan B, Verplank L, Fernandez C, Donckele E, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, Schreiber SL, Munoz B. Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. Bioorganic & Medicinal Chemistry Letters. 23: 1834-8. PMID 23403082 DOI: 10.1016/J.Bmcl.2013.01.025  0.666
2013 Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. Neuropharmacology. 64: 81-96. PMID 22771460 DOI: 10.1016/J.Neuropharm.2012.06.043  0.669
2013 Krönke J, Udeshi N, Narla A, Grauman P, Hurst S, McConkey M, Svinkina T, Heckl D, Comer E, Li X, Ciarlo C, Hartman E, Schenone M, Schreiber S, Carr SA, et al. Lenalidomide Promotes CRBN-Mediated Ubiquitination and Degradation of IKZF1 and IKZF3 Blood. 122: LBA-5-LBA-5. DOI: 10.1182/Blood.V122.21.Lba-5.Lba-5  0.372
2013 Schreiber SL. Abstract IA25: Linking genetic features of human cancers and histone-modifying enzymes for future cancer therapies Cancer Research. 73. DOI: 10.1158/1538-7445.Cec13-Ia25  0.31
2013 Ferrer-Luna R, Ramkissoon S, Cheah J, Lamothe R, Schumacher S, Shamji A, Clemons P, Reardon D, Wen P, Schreiber S, Ligon K, Beroukhim R. Abstract A103: High-throughput genomic and chemical screening in glioblastoma cell lines. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-A103  0.774
2012 Weïwer M, Spoonamore J, Wei J, Guichard B, Ross NT, Masson K, Silkworth W, Dandapani S, Palmer M, Scherer CA, Stern AM, Schreiber SL, Munoz B. A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. Acs Medicinal Chemistry Letters. 3: 1034-1038. PMID 23256033 DOI: 10.1021/Ml300246R  0.375
2012 Dockendorff C, Nagiec MM, Weïwer M, Buhrlage S, Ting A, Nag PP, Germain A, Kim HJ, Youngsaye W, Scherer C, Bennion M, Xue L, Stanton BZ, Lewis TA, Macpherson L, ... ... Schreiber SL, et al. Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies. Acs Medicinal Chemistry Letters. 3: 808-813. PMID 23074541 DOI: 10.1021/Ml300172P  0.638
2012 Adams DJ, Dai M, Pellegrino G, Wagner BK, Stern AM, Shamji AF, Schreiber SL. Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs. Proceedings of the National Academy of Sciences of the United States of America. 109: 15115-20. PMID 22949699 DOI: 10.1073/Pnas.1212802109  0.793
2012 Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, ... ... Schreiber SL, et al. Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. Cell. 150: 575-89. PMID 22863010 DOI: 10.1016/J.Cell.2012.06.032  0.677
2012 Chou DH, Holson EB, Wagner FF, Tang AJ, Maglathlin RL, Lewis TA, Schreiber SL, Wagner BK. Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis. Chemistry & Biology. 19: 669-73. PMID 22726680 DOI: 10.1016/J.Chembiol.2012.05.010  0.788
2012 Yuan Y, Wang Q, Paulk J, Kubicek S, Kemp MM, Adams DJ, Shamji AF, Wagner BK, Schreiber SL. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. Acs Chemical Biology. 7: 1152-7. PMID 22536950 DOI: 10.1021/Cb300139Y  0.805
2012 Germain AR, Carmody LC, Morgan B, Fernandez C, Forbeck E, Lewis TA, Nag PP, Ting A, VerPlank L, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, ... Schreiber SL, et al. Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorganic & Medicinal Chemistry Letters. 22: 3571-4. PMID 22503247 DOI: 10.1016/J.Bmcl.2012.01.035  0.662
2012 Kubicek S, Gilbert JC, Fomina-Yadlin D, Gitlin AD, Yuan Y, Wagner FF, Holson EB, Luo T, Lewis TA, Taylor B, Gupta S, Shamji AF, Wagner BK, Clemons PA, Schreiber SL. Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 5364-9. PMID 22434908 DOI: 10.1073/Pnas.1201079109  0.813
2012 Dockendorff C, Aisiku O, Verplank L, Dilks JR, Smith DA, Gunnink SF, Dowal L, Negri J, Palmer M, Macpherson L, Schreiber SL, Flaumenhaft R. Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor. Acs Medicinal Chemistry Letters. 3: 232-237. PMID 22408714 DOI: 10.1021/Ml2002696  0.339
2012 Heidebrecht RW, Mulrooney C, Austin CP, Barker RH, Beaudoin JA, Cheng KC, Comer E, Dandapani S, Dick J, Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M, Guha R, ... ... Schreiber S, et al. Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria. Acs Medicinal Chemistry Letters. 3: 112-117. PMID 22328964 DOI: 10.1021/Ml200244K  0.358
2012 Luo T, Masson K, Jaffe JD, Silkworth W, Ross NT, Scherer CA, Scholl C, Fröhling S, Carr SA, Stern AM, Schreiber SL, Golub TR. STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability. Proceedings of the National Academy of Sciences of the United States of America. 109: 2860-5. PMID 22323609 DOI: 10.1073/Pnas.1120589109  0.605
2012 Weïwer M, Bittker JA, Lewis TA, Shimada K, Yang WS, MacPherson L, Dandapani S, Palmer M, Stockwell BR, Schreiber SL, Munoz B. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorganic & Medicinal Chemistry Letters. 22: 1822-6. PMID 22297109 DOI: 10.1016/J.Bmcl.2011.09.047  0.574
2012 Fomina-Yadlin D, Kubicek S, Vetere A, He KH, He KH, Schreiber SL, Wagner BK. GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity. Plos One. 7: e28808. PMID 22242153 DOI: 10.1371/Journal.Pone.0028808  0.597
2012 Reed JC, White EL, Aub́ J, Lindsley C, Li M, Sklar L, Schreiber S. The NIH's role in accelerating translational sciences Nature Biotechnology. 30: 16-19. PMID 22231085 DOI: 10.1038/Nbt.2087  0.379
2012 Walpita D, Hasaka T, Spoonamore J, Vetere A, Takane KK, Fomina-Yadlin D, Fiaschi-Taesch N, Shamji A, Clemons PA, Stewart AF, Schreiber SL, Wagner BK. A human islet cell culture system for high-throughput screening. Journal of Biomolecular Screening. 17: 509-18. PMID 22156222 DOI: 10.1177/1087057111430253  0.794
2012 Ong SE, Li X, Schenone M, Schreiber SL, Carr SA. Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC. Methods in Molecular Biology (Clifton, N.J.). 803: 129-40. PMID 22065222 DOI: 10.1007/978-1-61779-364-6_9  0.356
2012 Schreiber SL. Towards a patient-based drug discovery Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S6-O30  0.351
2012 Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Carmody L, Yusuf RZ, Sykes DB, Vallet S, Santo L, Cirstea DD, Hideshima T, Dancik V, Cheah J, ... ... Schreiber SL, et al. Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma Blood. 120: 571-571. DOI: 10.1182/Blood.V120.21.571.571  0.821
2012 Schreiber SL. Abstract IA1: Cancer dependencies defined by genomic alterations and targeted by small molecules Cancer Research. 72. DOI: 10.1158/1538-7445.Csb12-Ia1  0.378
2011 Germain AR, Carmody LC, Dockendorff C, Galan-Rodriguez C, Rodriguez A, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Schreiber SL, Munoz B. Identification of small-molecule inhibitors of Trypansoma cruzi replication. Bioorganic & Medicinal Chemistry Letters. 21: 7197-200. PMID 22018462 DOI: 10.1016/J.Bmcl.2011.09.057  0.611
2011 Zhong C, Wang Y, Hung AW, Schreiber SL, Young DW. Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts. Organic Letters. 13: 5556-9. PMID 21916463 DOI: 10.1021/Ol202276H  0.725
2011 Kuai L, Ong SE, Madison JM, Wang X, Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, Haggarty SJ. AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics. Chemistry & Biology. 18: 891-906. PMID 21802010 DOI: 10.1016/J.Chembiol.2011.03.017  0.761
2011 Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 475: 231-4. PMID 21753854 DOI: 10.1038/Nature10167  0.667
2011 Wilson AJ, Holson E, Wagner F, Zhang YL, Fass DM, Haggarty SJ, Bhaskara S, Hiebert SW, Schreiber SL, Khabele D. The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells. Cancer Biology & Therapy. 12: 484-93. PMID 21738006 DOI: 10.4161/Cbt.12.6.15956  0.582
2011 Kemp MM, Wang Q, Fuller JH, West N, Martinez NM, Morse EM, Weïwer M, Schreiber SL, Bradner JE, Koehler AN. A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold. Bioorganic & Medicinal Chemistry Letters. 21: 4164-9. PMID 21696956 DOI: 10.1016/J.Bmcl.2011.05.098  0.818
2011 Luo X, Liu Y, Kubicek S, Myllyharju J, Tumber A, Ng S, Che KH, Podoll J, Heightman TD, Oppermann U, Schreiber SL, Wang X. A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases. Journal of the American Chemical Society. 133: 9451-6. PMID 21585201 DOI: 10.1021/Ja201597B  0.476
2011 Wang Y, Jimenez M, Hansen AS, Raiber EA, Schreiber SL, Young DW. Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group. Journal of the American Chemical Society. 133: 9196-9. PMID 21557625 DOI: 10.1021/Ja202012S  0.654
2011 Luo T, Dai M, Zheng SL, Schreiber SL. Syntheses of α-pyrones using gold-catalyzed coupling reactions. Organic Letters. 13: 2834-6. PMID 21534543 DOI: 10.1021/Ol200794W  0.609
2011 Clemons PA, Wilson JA, Dan?ík V, Muller S, Carrinski HA, Wagner BK, Koehler AN, Schreiber SL. Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections. Proceedings of the National Academy of Sciences of the United States of America. 108: 6817-22. PMID 21482810 DOI: 10.1073/Pnas.1015024108  0.811
2011 Tang W, Luo T, Greenberg EF, Bradner JE, Schreiber SL. Discovery of histone deacetylase 8 selective inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 2601-5. PMID 21334896 DOI: 10.1016/J.Bmcl.2011.01.134  0.738
2011 Shaw SY, Blodgett DM, Ma MS, Westly EC, Clemons PA, Subramanian A, Schreiber SL. Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes. Proceedings of the National Academy of Sciences of the United States of America. 108: 492-7. PMID 21183721 DOI: 10.1073/Pnas.1016789108  0.608
2011 Hartwell KA, Miller PG, Stewart AL, Kahn AR, Logan DJ, Negri J, Duvet M, Chattopadhyay S, Shterental S, Chu LP, Shieh JH, Jaeraas M, Dancik V, Narayan R, Huang C, ... ... Schreiber SL, et al. Niche-Based Screening Reveals Leukemia Stem Cell Specific Therapeutics Blood. 118: 760-760. DOI: 10.1182/Blood.V118.21.760.760  0.728
2010 Muncipinto G, Kaya T, Wilson JA, Kumagai N, Clemons PA, Schreiber SL. Expanding stereochemical and skeletal diversity using petasis reactions and 1,3-dipolar cycloadditions. Organic Letters. 12: 5230-3. PMID 20977261 DOI: 10.1021/Ol102266J  0.676
2010 Clemons PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, Schreiber SL. Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles. Proceedings of the National Academy of Sciences of the United States of America. 107: 18787-92. PMID 20956335 DOI: 10.1073/Pnas.1012741107  0.813
2010 Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, et al. Towards patient-based cancer therapeutics. Nature Biotechnology. 28: 904-6. PMID 20829823 DOI: 10.1038/Nbt0910-904  0.792
2010 Fomina-Yadlin D, Kubicek S, Walpita D, Dancik V, Hecksher-Sørensen J, Bittker JA, Sharifnia T, Shamji A, Clemons PA, Wagner BK, Schreiber SL. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 15099-104. PMID 20696901 DOI: 10.1073/Pnas.1010018107  0.8
2010 Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, ... ... Schreiber SL, et al. Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proceedings of the National Academy of Sciences of the United States of America. 107: 12617-22. PMID 20616024 DOI: 10.1073/Pnas.1006774107  0.772
2010 Dancík V, Seiler KP, Young DW, Schreiber SL, Clemons PA. Distinct biological network properties between the targets of natural products and disease genes. Journal of the American Chemical Society. 132: 9259-61. PMID 20565092 DOI: 10.1021/Ja102798T  0.694
2010 Chou DH, Bodycombe NE, Carrinski HA, Lewis TA, Clemons PA, Schreiber SL, Wagner BK. Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis. Acs Chemical Biology. 5: 729-34. PMID 20550176 DOI: 10.1021/Cb100129D  0.804
2010 Kuai L, Wang X, Madison JM, Schreiber SL, Scolnick EM, Haggarty SJ. Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling. Acs Chemical Neuroscience. 1: 325-342. PMID 20495671 DOI: 10.1021/Cn900046A  0.66
2010 Pizzirani D, Kaya T, Clemons PA, Schreiber SL. Stereochemical and skeletal diversity arising from amino propargylic alcohols Organic Letters. 12: 2822-2825. PMID 20481457 DOI: 10.1021/Ol100914B  0.555
2010 Radman-Livaja M, Liu CL, Friedman N, Schreiber SL, Rando OJ. Replication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast. Plos Genetics. 6: e1000837. PMID 20140185 DOI: 10.1371/Journal.Pgen.1000837  0.498
2010 Bracha AL, Ramanathan A, Huang S, Ingber DE, Schreiber SL. Carbon metabolism-mediated myogenic differentiation. Nature Chemical Biology. 6: 202-204. PMID 20081855 DOI: 10.1038/Nchembio.301  0.302
2010 Tassa C, Duffner JL, Lewis TA, Weissleder R, Schreiber SL, Koehler AN, Shaw SY. Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles. Bioconjugate Chemistry. 21: 14-9. PMID 20028085 DOI: 10.1021/Bc900438A  0.647
2010 Radman-Livaja M, Liu CL, Friedman N, Schreiber SL, Rando OJ. Replication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast Plos Genetics. 6. DOI: 10.1371/journal.pgen.1000837  0.476
2010 Wilson AJ, Holson E, Bhaskara S, Carlise J, Schreiber SL, Hiebert SW, Khabele D. Abstract 2985: DNA-damage related histone marks can distinguish the anti-tumor effects of established and novel histone deacetylase inhibitors in ovarian cancer cells Cancer Research. 70: 2985-2985. DOI: 10.1158/1538-7445.Am10-2985  0.319
2010 HUNG DT, NERENBERG JB, SCHREIBER SL. ChemInform Abstract: Syntheses of Discodermolides Useful for Investigating Microtubule Binding and Stabilization. Cheminform. 28: no-no. DOI: 10.1002/chin.199710185  0.489
2010 CHEN JK, SCHREIBER SL. ChemInform Abstract: Combinatorial Synthesis and Multi-Dimensional NMR Spectroscopy - An Understanding of Protein-Ligand Interactions Cheminform. 26: no-no. DOI: 10.1002/chin.199535318  0.41
2010 BELSHAW PJ, MEYER SD, JOHNSON DD, ROMO D, IKEDA Y, ANDRUS M, ALBERG DG, SCHULTZ LW, CLARDY J, SCHREIBER SL. ChemInform Abstract: Synthesis, Structure, and Mechanism in Immunophilin Research Cheminform. 26: no-no. DOI: 10.1002/chin.199502302  0.772
2010 NERENBERG JB, HUNG DT, SOMERS PK, SCHREIBER SL. ChemInform Abstract: Total Synthesis of the Immunosuppressive Agent (-)-Discodermolide. Cheminform. 25: no-no. DOI: 10.1002/chin.199415284  0.487
2010 TAUNTON J, WOOD JL, SCHREIBER SL. ChemInform Abstract: Total Syntheses of Di- and Tri-O-methyl Dynemicin A Methyl Esters. Cheminform. 25: no-no. DOI: 10.1002/CHIN.199407276  0.409
2010 WOOD JL, PORCO JAJ, TAUNTON J, LEE AY, CLARDY J, SCHREIBER SL. ChemInform Abstract: Application of the Allylic Diazene Rearrangement: Synthesis of the Enediyne-Bridged Tricyclic Core of Dynemicin A. Cheminform. 23: no-no. DOI: 10.1002/CHIN.199243262  0.443
2010 ROSEN MK, SCHREIBER SL. ChemInform Abstract: Natural Products as a Probe of Cellular Functions: Studies of Immunophilins Cheminform. 23: no-no. DOI: 10.1002/CHIN.199229318  0.447
2009 Ramanathan A, Schreiber SL. Direct control of mitochondrial function by mTOR. Proceedings of the National Academy of Sciences of the United States of America. 106: 22229-32. PMID 20080789 DOI: 10.1073/Pnas.0912074106  0.318
2009 Kelly KA, Shaw SY, Nahrendorf M, Kristoff K, Aikawa E, Schreiber SL, Clemons PA, Weissleder R. Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries. Integrative Biology : Quantitative Biosciences From Nano to Macro. 1: 311-7. PMID 20023731 DOI: 10.1039/B821775K  0.557
2009 Wang Q, Schreiber SL. Copper-mediated amidation of heterocyclic and aromatic C-H bonds. Organic Letters. 11: 5178-80. PMID 19860425 DOI: 10.1021/Ol902079G  0.45
2009 Peng LF, Stanton BZ, Maloof N, Wang X, Schreiber SL. Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog Bioorganic and Medicinal Chemistry Letters. 19: 6319-6325. PMID 19819139 DOI: 10.1016/J.Bmcl.2009.09.089  0.532
2009 Ruderfer DM, Roberts DC, Schreiber SL, Perlstein EO, Kruglyak L. Using expression and genotype to predict drug response in yeast. Plos One. 4: e6907. PMID 19730698 DOI: 10.1371/Journal.Pone.0006907  0.689
2009 Crabtree GR, Schreiber SL. SnapShot: Ca2+-calcineurin-NFAT signaling. Cell. 138: 210, 210.e1. PMID 19596245 DOI: 10.1016/J.Cell.2009.06.026  0.302
2009 de Bivort BL, Perlstein EO, Kunes S, Schreiber SL. Amino acid metabolic origin as an evolutionary influence on protein sequence in yeast. Journal of Molecular Evolution. 68: 490-7. PMID 19357800 DOI: 10.1007/S00239-009-9218-5  0.702
2009 Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell. 4: 348-58. PMID 19341624 DOI: 10.1016/J.Stem.2009.01.014  0.528
2009 Luo T, Schreiber SL. Gold(I)-catalyzed coupling reactions for the synthesis of diverse small molecules using the build/couple/pair strategy. Journal of the American Chemical Society. 131: 5667-74. PMID 19331418 DOI: 10.1021/Ja900414S  0.568
2009 Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. Journal of Medicinal Chemistry. 52: 2185-7. PMID 19317450 DOI: 10.1021/Jm801654Y  0.652
2009 Uchida T, Rodriquez M, Schreiber SL. Skeletally diverse small molecules using a build/couple/pair strategy. Organic Letters. 11: 1559-62. PMID 19275223 DOI: 10.1021/Ol900173T  0.307
2009 Ong SE, Schenone M, Margolin AA, Li X, Do K, Doud MK, Mani DR, Kuai L, Wang X, Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub TR, Gould RJ, ... Schreiber SL, et al. Identifying the proteins to which small-molecule probes and drugs bind in cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 4617-22. PMID 19255428 DOI: 10.1073/Pnas.0900191106  0.817
2009 Bowers AA, West N, Newkirk TL, Troutman-Youngman AE, Schreiber SL, Wiest O, Bradner JE, Williams RM. Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold. Organic Letters. 11: 1301-4. PMID 19239241 DOI: 10.1021/Ol900078K  0.612
2009 Bowers AA, Greshock TJ, West N, Estiu G, Schreiber SL, Wiest O, Williams RM, Bradner JE. Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole. Journal of the American Chemical Society. 131: 2900-5. PMID 19193120 DOI: 10.1021/Ja807772W  0.6
2009 Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nature Chemical Biology. 5: 154-6. PMID 19151731 DOI: 10.1038/Nchembio.142  0.764
2009 Altmann KH, Buchner J, Kessler H, Diederich F, Kräutler B, Lippard S, Liskamp R, Müller K, Nolan EM, Samori B, Schneider G, Schreiber SL, Schwalbe H, Toniolo C, van Boeckel CA, et al. The state of the art of chemical biology. Chembiochem : a European Journal of Chemical Biology. 10: 16-29. PMID 19115274 DOI: 10.1002/cbic.200800758  0.305
2008 Liu CL, Bernstein BE, Schreiber SL. Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): Overview. Csh Protocols. 2008: pdb.top42. PMID 21356838 DOI: 10.1101/Pdb.Top42  0.652
2008 Liu CL, Bernstein BE, Schreiber SL. Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): III. Sample Purification. Csh Protocols. 2008: pdb.prot5004. PMID 21356836 DOI: 10.1101/Pdb.Prot5004  0.65
2008 Liu CL, Bernstein BE, Schreiber SL. Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): II. Second-Strand Synthesis and In Vitro Transcription. Csh Protocols. 2008: pdb.prot5003. PMID 21356835 DOI: 10.1101/Pdb.Prot5003  0.652
2008 Liu CL, Bernstein BE, Schreiber SL. Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): I. CIP Treatment of Samples and Tailing Reaction with Terminal Transferase. Csh Protocols. 2008: pdb.prot5002. PMID 21356834 DOI: 10.1101/Pdb.Prot5002  0.654
2008 Bowers A, West N, Taunton J, Schreiber SL, Bradner JE, Williams RM. Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor. Journal of the American Chemical Society. 130: 11219-22. PMID 18642817 DOI: 10.1021/Ja8033763  0.726
2008 Gray BL, Wang X, Brown WC, Kuai L, Schreiber SL. Diversity synthesis of complex pyridines yields a probe of a neurotrophic signaling pathway. Organic Letters. 10: 2621-4. PMID 18510333 DOI: 10.1021/Ol8004936  0.502
2008 Wagner BK, Carrinski HA, Ahn YH, Kim YK, Gilbert TJ, Fomina DA, Schreiber SL, Chang YT, Clemons PA. Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening. Journal of the American Chemical Society. 130: 4208-9. PMID 18327938 DOI: 10.1021/Ja077656D  0.762
2008 Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, Mootha VK. Large-scale chemical dissection of mitochondrial function. Nature Biotechnology. 26: 343-51. PMID 18297058 DOI: 10.1038/Nbt1387  0.561
2008 Wang X, Imber BS, Schreiber SL. Small-molecule reagents for cellular pull-down experiments. Bioconjugate Chemistry. 19: 585-7. PMID 18193824 DOI: 10.1021/Bc700297J  0.5
2008 Nielsen TE, Schreiber SL. Towards the optimal screening collection: a synthesis strategy. Angewandte Chemie (International Ed. in English). 47: 48-56. PMID 18080276 DOI: 10.1002/anie.200703073  0.591
2008 Seiler KP, George GA, Happ MP, Bodycombe NE, Carrinski HA, Norton S, Brudz S, Sullivan JP, Muhlich J, Serrano M, Ferraiolo P, Tolliday NJ, Schreiber SL, Clemons PA. ChemBank: a small-molecule screening and cheminformatics resource database. Nucleic Acids Research. 36: D351-9. PMID 17947324 DOI: 10.1093/Nar/Gkm843  0.61
2008 Liu CL, Bernstein BE, Schreiber SL. Whole genome ampification by T7-based linear amplification of DNA (TLAD): I. CIP treatment of sample and tailing reaction with terminal transferase Cold Spring Harbor Protocols. 3. DOI: 10.1101/pdb.prot5002  0.605
2008 Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, Mootha VK. Large-scale chemical dissection of mitochondrial function (Nature Biotechnology (2008) 26 (343-351)) Nature Biotechnology. 26: 831. DOI: 10.1038/Nbt0708-831A  0.561
2008 Raisner RM, Hartley PD, Meneghini MD, Bao MZ, Liu CL, Schreiber SL, Rando OJ, Madhani HD. Histone Variant H2A.Z Marks the 5′ Ends of Both Active and Inactive Genes in Euchromatin (DOI:10.1016/j.cell.2005.10.002) Cell. 134: 188. DOI: 10.1016/j.cell.2008.06.046  0.489
2008 Haggarty SJ, Schreiber SL. Forward Chemical Genetics Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 1: 299-354. DOI: 10.1002/9783527619375.ch6  0.469
2008 Schreiber SL, Kapoor TM, Wess G. Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3 Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 1: 1-1205. DOI: 10.1002/9783527619375  0.494
2007 Gray BL, Schreiber SL. Skeletal diversity in small-molecule synthesis using ligand-controlled catalysis. Journal of Combinatorial Chemistry. 9: 1028-35. PMID 17960894 DOI: 10.1021/Cc7001028  0.327
2007 Luo T, Schreiber SL. Complex alpha-pyrones synthesized by a gold-catalyzed coupling reaction. Angewandte Chemie (International Ed. in English). 46: 8250-3. PMID 17893896 DOI: 10.1002/Anie.200703276  0.501
2007 Vegas AJ, Bradner JE, Tang W, McPherson OM, Greenberg EF, Koehler AN, Schreiber SL. Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors. Angewandte Chemie (International Ed. in English). 46: 7960-4. PMID 17868168 DOI: 10.1002/Anie.200703198  0.818
2007 Floto RA, Sarkar S, Perlstein EO, Kampmann B, Schreiber SL, Rubinsztein DC. Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages. Autophagy. 3: 620-2. PMID 17786022 DOI: 10.4161/Auto.4898  0.729
2007 Perlstein EO, de Bivort BL, Kunes S, Schreiber SL. Evolutionarily conserved optimization of amino acid biosynthesis. Journal of Molecular Evolution. 65: 186-96. PMID 17684697 DOI: 10.1007/S00239-007-0013-X  0.676
2007 Peng LF, Kim SS, Matchacheep S, Lei X, Su S, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB, Porco JA, Schreiber SL, Chung RT. Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Antimicrobial Agents and Chemotherapy. 51: 3756-9. PMID 17682098 DOI: 10.1128/Aac.00233-07  0.78
2007 Evensen E, Joseph-McCarthy D, Weiss GA, Schreiber SL, Karplus M. Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4. Journal of Computer-Aided Molecular Design. 21: 395-418. PMID 17657565 DOI: 10.1007/S10822-007-9119-X  0.613
2007 Perlstein EO, Deeds EJ, Ashenberg O, Shakhnovich EI, Schreiber SL. Quantifying fitness distributions and phenotypic relationships in recombinant yeast populations. Proceedings of the National Academy of Sciences of the United States of America. 104: 10553-8. PMID 17566105 DOI: 10.1073/Pnas.0704037104  0.683
2007 Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nature Chemical Biology. 3: 331-8. PMID 17486044 DOI: 10.1038/Nchembio883  0.81
2007 Yang J, Shamji A, Matchacheep S, Schreiber SL. Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening. Chemistry & Biology. 14: 371-7. PMID 17462572 DOI: 10.1016/J.Chembiol.2007.02.004  0.808
2007 Miao H, Tallarico JA, Hayakawa H, Münger K, Duffner JL, Koehler AN, Schreiber SL, Lewis TA. Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules. Journal of Combinatorial Chemistry. 9: 245-53. PMID 17348730 DOI: 10.1021/Cc060135M  0.782
2007 Perlstein EO, Ruderfer DM, Roberts DC, Schreiber SL, Kruglyak L. Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nature Genetics. 39: 496-502. PMID 17334364 DOI: 10.1038/Ng1991  0.715
2007 Franz AK, Dreyfuss PD, Schreiber SL. Synthesis and cellular profiling of diverse organosilicon small molecules. Journal of the American Chemical Society. 129: 1020-1. PMID 17263369 DOI: 10.1021/Ja067552N  0.687
2007 Kim SS, Peng LF, Lin W, Choe WH, Sakamoto N, Kato N, Ikeda M, Schreiber SL, Chung RT. A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication. Gastroenterology. 132: 311-20. PMID 17241881 DOI: 10.1053/J.Gastro.2006.10.032  0.322
2007 Bradner J, Greenberg E, Ponduru S, Patel V, Schreiber S, Rich B, Mazitschek R. A Soft-Drug Histone Deacetylase Inhibitor for Cutaneous T-Cell Lymphoma. Blood. 110: 800-800. DOI: 10.1182/Blood.V110.11.800.800  0.55
2007 Shen JP, Divakaran S, Kuai L, Wang X, Ong S, Amaravadi R, Wood J, Carr S, Schreiber S, Haggarty S, Bradner J. Autophagy as a Target Pathway in Multiple Myeloma: A Forward Chemical Genetic Approach. Blood. 110: 2510-2510. DOI: 10.1182/Blood.V110.11.2510.2510  0.809
2006 Spiegel DA, Schroeder FC, Duvall JR, Schreiber SL. An oligomer-based approach to skeletal diversity in small-molecule synthesis. Journal of the American Chemical Society. 128: 14766-7. PMID 17105261 DOI: 10.1021/Ja065724A  0.612
2006 Tolliday N, Clemons PA, Ferraiolo P, Koehler AN, Lewis TA, Li X, Schreiber SL, Gerhard DS, Eliasof S. Small molecules, big players: the National Cancer Institute's Initiative for Chemical Genetics. Cancer Research. 66: 8935-42. PMID 16982730 DOI: 10.1158/0008-5472.Can-06-2552  0.753
2006 Klekota J, Brauner E, Roth FP, Schreiber SL. Using high-throughput screening data to discriminate compounds with single-target effects from those with side effects. Journal of Chemical Information and Modeling. 46: 1549-62. PMID 16859287 DOI: 10.1021/Ci050495H  0.801
2006 Bradner JE, McPherson OM, Mazitschek R, Barnes-Seeman D, Shen JP, Dhaliwal J, Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P, Schreiber SL, Koehler AN. A robust small-molecule microarray platform for screening cell lysates. Chemistry & Biology. 13: 493-504. PMID 16720270 DOI: 10.1016/J.Chembiol.2006.03.004  0.813
2006 Klekota J, Roth FP, Schreiber SL. Query Chem: a Google-powered web search combining text and chemical structures. Bioinformatics (Oxford, England). 22: 1670-3. PMID 16672261 DOI: 10.1093/Bioinformatics/Btl155  0.771
2006 Kumagai N, Muncipinto G, Schreiber SL. Short synthesis of skeletally and stereochemically diverse small molecules by coupling petasis condensation reactions to cyclization reactions. Angewandte Chemie (International Ed. in English). 45: 3635-8. PMID 16646101 DOI: 10.1002/anie.200600497  0.477
2006 Perlstein EO, Ruderfer DM, Ramachandran G, Haggarty SJ, Kruglyak L, Schreiber SL. Revealing complex traits with small molecules and naturally recombinant yeast strains. Chemistry & Biology. 13: 319-27. PMID 16638537 DOI: 10.1016/J.Chembiol.2006.01.010  0.774
2006 Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber SL, Lander ES. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell. 125: 315-26. PMID 16630819 DOI: 10.1016/J.Cell.2006.02.041  0.595
2006 Butcher RA, Bhullar BS, Perlstein EO, Marsischky G, LaBaer J, Schreiber SL. Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway Nature Chemical Biology. 2: 103-109. PMID 16415861 DOI: 10.1038/Nchembio762  0.749
2006 Bradner JE, Greenberg EF, Schreiber SL, Mazitschek R. Design and Characterization of a Novel, Reverse Prodrug Histone Deacetylase Inhibitor for Cutaneous T-Cell Lymphoma. Blood. 108: 4759-4759. DOI: 10.1182/Blood.V108.11.4759.4759  0.527
2006 Hideshima T, Bradner JE, Yasui H, Raje N, Chauhan D, Podar K, Tai Y, Mitsiades C, Richardson PG, Mazitschek R, Schreiber SL, Anderson KC. Histone Deacetylase-6 (HDAC6) Modulates Akt and STAT3 Activity Via Heat Shock Protein (Hsp) 90 in Human Multiple Myeloma (MM) Cells. Blood. 108: 3426-3426. DOI: 10.1182/blood.V108.11.3426.3426  0.469
2006 Bradner JE, Shen JP, Perlstein EO, Divakaran S, Greenberg EF, Amaravadi R, Schreiber SL. Discovery and Characterization of Small Molecule Inhibitors of Autophagy for Cancer Therapy. Blood. 108: 2606-2606. DOI: 10.1182/Blood.V108.11.2606.2606  0.823
2005 Klekota J, Brauner E, Schreiber SL. Identifying biologically active compound classes using phenotypic screening data and sampling statistics. Journal of Chemical Information and Modeling. 45: 1824-36. PMID 16309290 DOI: 10.1021/Ci050087D  0.794
2005 Raisner RM, Hartley PD, Meneghini MD, Bao MZ, Liu CL, Schreiber SL, Rando OJ, Madhani HD. Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell. 123: 233-48. PMID 16239142 DOI: 10.1016/J.Cell.2005.10.002  0.537
2005 Forman JJ, Clemons PA, Schreiber SL, Haggarty SJ. SpectralNET--an application for spectral graph analysis and visualization. Bmc Bioinformatics. 6: 260. PMID 16236170 DOI: 10.1186/1471-2105-6-260  0.637
2005 Liu CL, Kaplan T, Kim M, Buratowski S, Schreiber SL, Friedman N, Rando OJ. Single-nucleosome mapping of histone modifications in S. cerevisiae. Plos Biology. 3: e328. PMID 16122352 DOI: 10.1371/Journal.Pbio.0030328  0.537
2005 Kumar N, Kiuchi M, Tallarico JA, Schreiber SL. Small-molecule diversity using a skeletal transformation strategy. Organic Letters. 7: 2535-8. PMID 15957884 DOI: 10.1021/Ol0504345  0.704
2005 Hideshima T, Bradner JE, Wong J, Chauhan D, Richardson P, Schreiber SL, Anderson KC. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America. 102: 8567-72. PMID 15937109 DOI: 10.1073/Pnas.0503221102  0.669
2005 Van Stry M, Kazlauskas A, Schreiber SL, Symes K. Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 8233-8. PMID 15919820 DOI: 10.1073/Pnas.0502885102  0.311
2005 Ramanathan A, Wang C, Schreiber SL. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proceedings of the National Academy of Sciences of the United States of America. 102: 5992-7. PMID 15840712 DOI: 10.1073/Pnas.0502267102  0.325
2005 Saji S, Kawakami M, Hayashi S, Yoshida N, Hirose M, Horiguchi S, Itoh A, Funata N, Schreiber SL, Yoshida M, Toi M. Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Oncogene. 24: 4531-9. PMID 15806142 DOI: 10.1038/Sj.Onc.1208646  0.317
2005 Chen C, Li X, Neumann CS, Lo MM, Schreiber SL. Convergent diversity-oriented synthesis of small-molecule hybrids. Angewandte Chemie (International Ed. in English). 44: 2249-52. PMID 15747386 DOI: 10.1002/Anie.200462798  0.769
2005 Bernstein BE, Kamal M, Lindblad-Toh K, Bekiranov S, Bailey DK, Huebert DJ, McMahon S, Karlsson EK, Kulbokas EJ, Gingeras TR, Schreiber SL, Lander ES. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell. 120: 169-81. PMID 15680324 DOI: 10.1016/J.Cell.2005.01.001  0.612
2005 Oguri H, Schreiber SL. Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons. Organic Letters. 7: 47-50. PMID 15624974 DOI: 10.1021/Ol047945W  0.313
2005 Saji S, Kawakami M, Hayashi S, Horiguchi S, Yoshida M, Schreiber SL, Toi M. Utility of Histone deacetylase 6, a novel estrogen regulated gene affecting cell motility, as predictive factor for adjuvant endocrine treatment and as therapeutic target Journal of Clinical Oncology. 23: 641-641. DOI: 10.1200/Jco.2005.23.16_Suppl.641  0.317
2005 Bradner J, Shen JP, Greenberg E, Hideshima T, Anderson KC, Schreiber SL. Targeting the Protein Degradation Pathway in Multiple Myeloma with Synergistic, Selective Small Molecules. Blood. 106: 2471-2471. DOI: 10.1182/Blood.V106.11.2471.2471  0.586
2004 Lo MM, Neumann CS, Nagayama S, Perlstein EO, Schreiber SL. A library of spirooxindoles based on a stereoselective three-component coupling reaction. Journal of the American Chemical Society. 126: 16077-86. PMID 15584743 DOI: 10.1021/Ja045089D  0.812
2004 Haggarty SJ, Clemons PA, Wong JC, Schreiber SL. Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors. Combinatorial Chemistry & High Throughput Screening. 7: 669-76. PMID 15578929 DOI: 10.2174/1386207043328319  0.771
2004 Huang J, Zhu H, Haggarty SJ, Spring DR, Hwang H, Jin F, Snyder M, Schreiber SL. Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proceedings of the National Academy of Sciences of the United States of America. 101: 16594-9. PMID 15539461 DOI: 10.1073/Pnas.0407117101  0.708
2004 Kim YK, Arai MA, Arai T, Lamenzo JO, Dean EF, Patterson N, Clemons PA, Schreiber SL. Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space. Journal of the American Chemical Society. 126: 14740-5. PMID 15535697 DOI: 10.1021/Ja048170P  0.681
2004 Andreana PR, Liu CC, Schreiber SL. Stereochemical control of the Passerini reaction. Organic Letters. 6: 4231-3. PMID 15524450 DOI: 10.1021/Ol0482893  0.616
2004 Burke MD, Berger EM, Schreiber SL. A synthesis strategy yielding skeletally diverse small molecules combinatorially. Journal of the American Chemical Society. 126: 14095-104. PMID 15506774 DOI: 10.1021/Ja0457415  0.572
2004 Krishnan S, Schreiber SL. Syntheses of stereochemically diverse nine-membered ring-containing biaryls. Organic Letters. 6: 4021-4. PMID 15496089 DOI: 10.1021/Ol048273C  0.486
2004 Wong JC, Sternson SM, Louca JB, Hong R, Schreiber SL. Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes. Chemistry & Biology. 11: 1279-91. PMID 15380188 DOI: 10.1016/J.Chembiol.2004.07.012  0.76
2004 Bernstein BE, Liu CL, Humphrey EL, Perlstein EO, Schreiber SL. Global nucleosome occupancy in yeast. Genome Biology. 5: R62. PMID 15345046 DOI: 10.1186/Gb-2004-5-9-R62  0.787
2004 Butcher RA, Schreiber SL. Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection. Proceedings of the National Academy of Sciences of the United States of America. 101: 7868-73. PMID 15146068 DOI: 10.1073/Pnas.0402317101  0.385
2004 Humphrey EL, Shamji AF, Bernstein BE, Schreiber SL. Rpd3p relocation mediates a transcriptional response to rapamycin in yeast. Chemistry & Biology. 11: 295-9. PMID 15123258 DOI: 10.1016/J.Chembiol.2004.03.001  0.794
2004 Peterson RT, Shaw SY, Peterson TA, Milan DJ, Zhong TP, Schreiber SL, MacRae CA, Fishman MC. Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nature Biotechnology. 22: 595-9. PMID 15097998 DOI: 10.1038/Nbt963  0.544
2004 Taylor SJ, Taylor AM, Schreiber SL. Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates. Angewandte Chemie (International Ed. in English). 43: 1681-5. PMID 15038036 DOI: 10.1002/Anie.200353466  0.532
2004 Schmidt DR, Kwon O, Schreiber SL. Macrolactones in diversity-oriented synthesis: preparation of a pilot library and exploration of factors controlling macrocyclization. Journal of Combinatorial Chemistry. 6: 286-92. PMID 15002980 DOI: 10.1021/Cc020076M  0.651
2004 Bernstein BE, Humphrey EL, Liu CL, Schreiber SL. The use of chromatin immunoprecipitation assays in genome-wide analyses of histone modifications. Methods in Enzymology. 376: 349-60. PMID 14975317 DOI: 10.1016/S0076-6879(03)76023-6  0.783
2004 Burke MD, Schreiber SL. A planning strategy for diversity-oriented synthesis. Angewandte Chemie (International Ed. in English). 43: 46-58. PMID 14694470 DOI: 10.1002/Anie.200300626  0.536
2004 Butcher RA, Schreiber SL. A small molecule suppressor of FK506 that targets the mitochondria and modulates ionic balance in Saccharomyces cerevisiae. Chemistry & Biology. 10: 521-31. PMID 12837385 DOI: 10.1016/S1074-5521(03)00108-X  0.318
2004 Bradner J, Kim Y, Koehler A, Kawasumi M, Li X, Schreiber SL, Nghiem P. Identification and Characterization of Novel Small-Molecule Inhibitors of the Replication Checkpoint. Blood. 104: 763-763. DOI: 10.1182/Blood.V104.11.763.763  0.785
2004 Burke MD, Schreiber SL. Eine Strategie für die Diversitäts-orientierte Synthese Angewandte Chemie. 116: 48-60. DOI: 10.1002/Ange.200300626  0.456
2003 Haggarty SJ, Koeller KM, Kau TR, Silver PA, Roberge M, Schreiber SL. Small molecule modulation of the human chromatid decatenation checkpoint. Chemistry & Biology. 10: 1267-79. PMID 14700634 DOI: 10.1016/J.Chembiol.2003.11.014  0.747
2003 Santos-Rosa H, Schneider R, Bernstein BE, Karabetsou N, Morillon A, Weise C, Schreiber SL, Mellor J, Kouzarides T. Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin Molecular Cell. 12: 1325-1332. PMID 14636589 DOI: 10.1016/S1097-2765(03)00438-6  0.53
2003 Burke MD, Berger EM, Schreiber SL. Generating diverse skeletons of small molecules combinatorially. Science (New York, N.Y.). 302: 613-8. PMID 14576427 DOI: 10.1126/Science.1089946  0.543
2003 Sello JK, Andreana PR, Lee D, Schreiber SL. Stereochemical control of skeletal diversity. Organic Letters. 5: 4125-7. PMID 14572265 DOI: 10.1021/Ol035773H  0.775
2003 Shamji AF, Nghiem P, Schreiber SL. Integration of growth factor and nutrient signaling: implications for cancer biology. Molecular Cell. 12: 271-80. PMID 14536067 DOI: 10.1016/J.Molcel.2003.08.016  0.64
2003 Haggarty SJ, Clemons PA, Schreiber SL. Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations. Journal of the American Chemical Society. 125: 10543-5. PMID 12940736 DOI: 10.1021/Ja035413P  0.692
2003 Chen C, Li X, Schreiber SL. Catalytic asymmetric [3+2] cycloaddition of azomethine ylides. Development of a versatile stepwise, three-component reaction for diversity-oriented synthesis. Journal of the American Chemical Society. 125: 10174-5. PMID 12926931 DOI: 10.1021/Ja036558Z  0.628
2003 Zhao Y, Dai X, Blackwell HE, Schreiber SL, Chory J. SIR1, an upstream component in auxin signaling identified by chemical genetics. Science (New York, N.Y.). 301: 1107-10. PMID 12893885 DOI: 10.1126/Science.1084161  0.541
2003 Koehler AN, Shamji AF, Schreiber SL. Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis. Journal of the American Chemical Society. 125: 8420-1. PMID 12848532 DOI: 10.1021/Ja0352698  0.802
2003 Barnes-Seeman D, Park SB, Koehler AN, Schreiber SL. Expanding the functional group compatibility of small-molecule microarrays: discovery of novel calmodulin ligands. Angewandte Chemie (International Ed. in English). 42: 2376-9. PMID 12783500 DOI: 10.1002/Anie.200351043  0.703
2003 Koeller KM, Haggarty SJ, Perkins BD, Leykin I, Wong JC, Kao MC, Schreiber SL. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chemistry & Biology. 10: 397-410. PMID 12770822 DOI: 10.1016/S1074-5521(03)00093-0  0.794
2003 Haggarty SJ, Koeller KM, Wong JC, Butcher RA, Schreiber SL. Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. Chemistry & Biology. 10: 383-96. PMID 12770821 DOI: 10.1016/S1074-5521(03)00095-4  0.804
2003 Liu CL, Schreiber SL, Bernstein BE. Development and validation of a T7 based linear amplification for genomic DNA. Bmc Genomics. 4: 19. PMID 12740028 DOI: 10.1186/1471-2164-4-19  0.628
2003 Wong JC, Hong R, Schreiber SL. Structural biasing elements for in-cell histone deacetylase paralog selectivity. Journal of the American Chemical Society. 125: 5586-7. PMID 12733869 DOI: 10.1021/Ja0341440  0.554
2003 Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, Schreiber SL. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proceedings of the National Academy of Sciences of the United States of America. 100: 4389-94. PMID 12677000 DOI: 10.1073/Pnas.0430973100  0.806
2003 Barnes-Seeman D, Park SB, Koehler AN, Schreiber SL. Cover Picture: Expanding the Functional Group Compatibility of Small-Molecule Microarrays: Discovery of Novel Calmodulin Ligands (Angew. Chem. Int. Ed. 21/2003) Angewandte Chemie International Edition. 42: 2319-2319. DOI: 10.1002/Anie.200390464  0.704
2003 Barnes-Seeman D, Park SB, Koehler AN, Schreiber SL. Titelbild: Expanding the Functional Group Compatibility of Small-Molecule Microarrays: Discovery of Novel Calmodulin Ligands (Angew. Chem. 21/2003) Angewandte Chemie. 115: 2421-2421. DOI: 10.1002/Ange.200390491  0.703
2002 Schreiber SL, Bernstein BE. Signaling network model of chromatin. Cell. 111: 771-8. PMID 12526804 DOI: 10.1016/S0092-8674(02)01196-0  0.485
2002 Micalizio GC, Schreiber SL. A boronic ester annulation strategy for diversity-oriented organic synthesis. Angewandte Chemie (International Ed. in English). 41: 152-4. PMID 12491469 DOI: 10.1002/1521-3773(20020104)41:1<152::Aid-Anie152>3.0.Co;2-N  0.544
2002 Bernstein BE, Schreiber SL. Global approaches to chromatin. Chemistry & Biology. 9: 1167-73. PMID 12445767 DOI: 10.1016/S1074-5521(02)00265-X  0.5
2002 Kwon O, Park SB, Schreiber SL. Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions. Journal of the American Chemical Society. 124: 13402-4. PMID 12418890 DOI: 10.1021/Ja028086E  0.644
2002 Santos-Rosa H, Schneider R, Bannister AJ, Sherriff J, Bernstein BE, Emre NC, Schreiber SL, Mellor J, Kouzarides T. Active genes are tri-methylated at K4 of histone H3. Nature. 419: 407-11. PMID 12353038 DOI: 10.1038/Nature01080  0.517
2002 Micalizio GC, Schreiber SL. An alkynylboronic ester annulation: development of synthetic methods for application to diversity-oriented organic synthesis. Angewandte Chemie (International Ed. in English). 41: 3272-6. PMID 12207413 DOI: 10.1002/1521-3773(20020902)41:17<3272::Aid-Anie3272>3.0.Co;2-C  0.544
2002 Bernstein BE, Humphrey EL, Erlich RL, Schneider R, Bouman P, Liu JS, Kouzarides T, Schreiber SL. Methylation of histone H3 Lys 4 in coding regions of active genes. Proceedings of the National Academy of Sciences of the United States of America. 99: 8695-700. PMID 12060701 DOI: 10.1073/Pnas.082249499  0.774
2002 Kuruvilla FG, Shamji AF, Sternson SM, Hergenrother PJ, Schreiber SL. Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays. Nature. 416: 653-7. PMID 11948353 DOI: 10.1038/416653A  0.814
2002 Desai BN, Myers BR, Schreiber SL. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 99: 4319-24. PMID 11930000 DOI: 10.1073/Pnas.261702698  0.634
2002 Kuruvilla FG, Park PJ, Schreiber SL. Vector algebra in the analysis of genome-wide expression data. Genome Biology. 3: RESEARCH0011. PMID 11897023 DOI: 10.1186/Gb-2002-3-3-Research0011  0.767
2002 Kubota H, Lim J, Depew KM, Schreiber SL. Pathway development and pilot library realization in diversity-oriented synthesis: exploring Ferrier and Pauson-Khand reactions on a glycal template. Chemistry & Biology. 9: 265-76. PMID 11880041 DOI: 10.1016/S1074-5521(02)00099-6  0.522
2002 Clemons PA, Gladstone BG, Seth A, Chao ED, Foley MA, Schreiber SL. Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors. Chemistry & Biology. 9: 49-61. PMID 11841938 DOI: 10.1016/S1074-5521(02)00085-6  0.804
2002 Grozinger CM, Schreiber SL. Deacetylase enzymes: biological functions and the use of small-molecule inhibitors. Chemistry & Biology. 9: 3-16. PMID 11841934 DOI: 10.1016/S1074-5521(02)00092-3  0.539
2002 Schreiber SL, Nicolaou KC, Davies K. Diversity-oriented organic synthesis and proteomics. New frontiers for chemistry & biology. Chemistry & Biology. 9: 1-2. PMID 11841933 DOI: 10.1016/S1074-5521(02)00088-1  0.342
2002 Spring DR, Krishnan S, Blackwell HE, Schreiber SL. Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform. Journal of the American Chemical Society. 124: 1354-63. PMID 11841305 DOI: 10.1021/Ja017248O  0.74
2002 Nghiem P, Park PK, Kim Ys YS, Desai BN, Schreiber SL. ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint. The Journal of Biological Chemistry. 277: 4428-34. PMID 11711532 DOI: 10.1074/Jbc.M106113200  0.605
2001 Sternson SM, Wong JC, Grozinger CM, Schreiber SL. Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin. Organic Letters. 3: 4239-42. PMID 11784187 DOI: 10.1021/Ol016915F  0.802
2001 Clemons PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, Foley MA. A one-bead, one-stock solution approach to chemical genetics: part 2. Chemistry & Biology. 8: 1183-95. PMID 11755397 DOI: 10.1016/S1074-5521(01)00086-2  0.806
2001 Blackwell HE, Pérez L, Stavenger RA, Tallarico JA, Cope Eatough E, Foley MA, Schreiber SL. A one-bead, one-stock solution approach to chemical genetics: part 1. Chemistry & Biology. 8: 1167-82. PMID 11755396 DOI: 10.1016/S1074-5521(01)00085-0  0.812
2001 Pflum MK, Tong JK, Lane WS, Schreiber SL. Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation. The Journal of Biological Chemistry. 276: 47733-41. PMID 11602581 DOI: 10.1074/Jbc.M105590200  0.794
2001 Blackwell HE, Pérez L, Schreiber SL. Decoding Products of Diversity Pathways from Stock Solutions Derived from Single Polymeric Macrobeads H.E.B. and L.P. contributed equally to this work. We thank the National Institute of General Medical Sciences (GM-52067) for the support of this research. We are especially grateful to Dr. Andrew Tyler for expert mass spectroscopy support. The Harvard ICCB is supported by Merck & Co., Merck KGaA, the Keck Foundation, and the National Cancer Institute. H.E.B. is supported by a postdoctoral fellowship from the Jane Coffin Childs Memorial Fund for Medical Research (sponsored by Merck & Co.). L.P. is a Research Fellow, and S.L.S. is an Investigator with the Howard Hughes Medical Institute at the Department of Chemistry and Chemical Biology, Harvard University. Angewandte Chemie (International Ed. in English). 40: 3421-3425. PMID 11592158 DOI: 10.1002/1521-3773(20010917)40:18<3421::Aid-Anie3421>3.0.Co;2-B  0.508
2001 Stavenger RA, Schreiber SL. Asymmetric Catalysis in Diversity-Oriented Organic Synthesis: Enantioselective Synthesis of 4320 Encoded and Spatially Segregated Dihydropyrancarboxamides We thank the National Institute of General Medical Sciences (GM-52067) for support of this research, and Dr. John Tallarico and Max Narovlyansky at the ICCB for generously providing resin for the library synthesis. We thank Dr. Helen Blackwell and Lucy Pérez for expert help with library encoding. We are grateful to Prof. Eric Jacobsen and Prof. Scott Denmark for the use of their chiral stationary phase high pressure liquid chromatograph and supercritical fluid chromatograph, respectively. The Harvard ICCB is supported by Merck & Co., Merck KGaA, the Keck Foundation, and the National Cancer Institute. R.A.S. is a Research Associate and S.L.S. is an Investigator with the Howard Hughes Medical Institute at the Department of Chemistry and Chemical Biology, Harvard University. Angewandte Chemie (International Ed. in English). 40: 3417-3421. PMID 11592157 DOI: 10.1002/1521-3773(20010917)40:18<3417::AID-ANIE3417>3.0.CO;2-E  0.637
2001 Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. The Journal of Biological Chemistry. 276: 38837-43. PMID 11483616 DOI: 10.1074/Jbc.M106779200  0.732
2001 Nghiem P, Park PK, Kim Y, Vaziri C, Schreiber SL. ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proceedings of the National Academy of Sciences of the United States of America. 98: 9092-7. PMID 11481475 DOI: 10.1073/Pnas.161281798  0.523
2001 Sternson SM, Louca JB, Wong JC, Schreiber SL. Split--pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays. Journal of the American Chemical Society. 123: 1740-7. PMID 11456775 DOI: 10.1021/Ja0036108  0.772
2001 Kuruvilla FG, Shamji AF, Schreiber SL. Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors. Proceedings of the National Academy of Sciences of the United States of America. 98: 7283-8. PMID 11416207 DOI: 10.1073/Pnas.121186898  0.787
2001 Tallarico JA, Depew KM, Pelish HE, Westwood NJ, Lindsley CW, Shair MD, Schreiber SL, Foley MA. An alkylsilyl-tethered, high-capacity solid support amenable to diversity-oriented synthesis for one-bead, one-stock solution chemical genetics. Journal of Combinatorial Chemistry. 3: 312-8. PMID 11350255 DOI: 10.1021/Cc000107I  0.79
2001 Blackwell HE, Clemons PA, Schreiber SL. Exploiting site-site interactions on solid support to generate dimeric molecules. Organic Letters. 3: 1185-8. PMID 11348190 DOI: 10.1021/Ol015647I  0.658
2001 You A, Tong JK, Grozinger CM, Schreiber SL. CoREST is an integral component of the CoREST- human histone deacetylase complex. Proceedings of the National Academy of Sciences of the United States of America. 98: 1454-8. PMID 11171972 DOI: 10.1073/Pnas.98.4.1454  0.77
2001 Blackwell HE, Pérez L, Stavenger RA, Tallarico JA, Cope Eatough E, Foley MA, Schreiber SL. A one-bead, one-stock solution approach to chemical genetics: Part 1 Chemistry and Biology. 8: 1167-1182. DOI: 10.1016/S1074-5521(01)00085-0  0.766
2001 Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, J. Mitchison T, Schreiber SL. Erratum to ‘Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis’ Chemistry & Biology. 8: 1265. DOI: 10.1016/S1074-5521(01)00083-7  0.682
2001 Tan DS, Schreiber SL. ChemInform Abstract: A Mercury-Catalyzed Transetherification Cyclization Leading to Fused Cyclic Polyethers. Cheminform. 32: no-no. DOI: 10.1002/chin.200110208  0.464
2000 Shamji AF, Kuruvilla FG, Schreiber SL. Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins. Current Biology : Cb. 10: 1574-81. PMID 11137008 DOI: 10.1016/S0960-9822(00)00866-6  0.787
2000 Bernstein BE, Tong JK, Schreiber SL. Genomewide studies of histone deacetylase function in yeast. Proceedings of the National Academy of Sciences of the United States of America. 97: 13708-13. PMID 11095743 DOI: 10.1073/Pnas.250477697  0.77
2000 Peterson RT, Link BA, Dowling JE, Schreiber SL. Small molecule developmental screens reveal the logic and timing of vertebrate development. Proceedings of the National Academy of Sciences of the United States of America. 97: 12965-9. PMID 11087852 DOI: 10.1073/Pnas.97.24.12965  0.581
2000 Zhou G, Ferrer M, Chopra R, Kapoor TM, Strassmaier T, Weissenhorn W, Skehel JJ, Oprian D, Schreiber SL, Harrison SC, Wiley DC. The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core. Bioorganic & Medicinal Chemistry. 8: 2219-27. PMID 11026535 DOI: 10.1016/S0968-0896(00)00155-3  0.563
2000 MacBeath G, Schreiber SL. Printing proteins as microarrays for high-throughput function determination. Science (New York, N.Y.). 289: 1760-3. PMID 10976071 DOI: 10.1126/Science.289.5485.1760  0.507
2000 Grozinger CM, Schreiber SL. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proceedings of the National Academy of Sciences of the United States of America. 97: 7835-40. PMID 10869435 DOI: 10.1073/Pnas.140199597  0.587
2000 Lee D, Sello JK, Schreiber SL. Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis. Organic Letters. 2: 709-12. PMID 10814416 DOI: 10.1021/Ol005574N  0.741
2000 Liberles SD, Schreiber SL. Apoptosis-inducing natural products found in utero during murine pregnancy. Chemistry & Biology. 7: 365-72. PMID 10801475 DOI: 10.1016/S1074-5521(00)00114-9  0.622
2000 Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL. Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chemistry & Biology. 7: 275-86. PMID 10780927 DOI: 10.1016/S1074-5521(00)00101-0  0.771
2000 Peterson RT, Beal PA, Comb MJ, Schreiber SL. FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions. The Journal of Biological Chemistry. 275: 7416-23. PMID 10702316 DOI: 10.1074/Jbc.275.10.7416  0.67
2000 Walters MA, Tan DS, Foley MA, Stockwell BR, Shair MD, Schreiber SL. Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays Chemtracts. 13: 268-275. DOI: 10.1021/Ja992144N  0.798
2000 Hergenrother PJ, Depew KM, Schreiber SL. Small-molecule microarrays: Covalent attachment and screening of alcohol-containing small molecules on glass slides [20] Journal of the American Chemical Society. 122: 7849-7850. DOI: 10.1021/Ja0014032  0.549
2000 Spring DR, Krishnan S, Schreiber SL. Towards Diversity-Oriented, Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings Journal of the American Chemical Society. 122: 5656-5657. DOI: 10.1021/Ja0010507  0.597
2000 Tan DS, Schreiber SL. A mercury-catalyzed transetherification cyclization leading to fused cyclic polyethers Tetrahedron Letters. 41: 9509-9513. DOI: 10.1016/S0040-4039(00)01658-0  0.472
2000 Spring DR, Krishnan S, Schreiber SL. ChemInform Abstract: Towards Diversity-Oriented Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings. Cheminform. 31: no-no. DOI: 10.1002/chin.200040155  0.411
1999 Hardwick JS, Kuruvilla FG, Tong JK, Shamji AF, Schreiber SL. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proceedings of the National Academy of Sciences of the United States of America. 96: 14866-70. PMID 10611304 DOI: 10.1073/Pnas.96.26.14866  0.8
1999 Schmidt DR, Schreiber SL. Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. Biochemistry. 38: 14711-7. PMID 10545197 DOI: 10.1021/Bi991614N  0.576
1999 Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science (New York, N.Y.). 286: 971-4. PMID 10542155 DOI: 10.1126/Science.286.5441.971  0.802
1999 Ferrer M, Kapoor TM, Strassmaier T, Weissenhorn W, Skehel JJ, Oprian D, Schreiber SL, Wiley DC, Harrison SC. Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements. Nature Structural Biology. 6: 953-60. PMID 10504731 DOI: 10.1038/13324  0.562
1999 Peterson RT, Schreiber SL. Kinase phosphorylation: Keeping it all in the family. Current Biology : Cb. 9: R521-4. PMID 10421571 DOI: 10.1016/S0960-9822(99)80326-1  0.452
1999 Kuruvilla FG, Schreiber SL. The PIK-related kinases intercept conventional signaling pathways. Chemistry & Biology. 6: R129-36. PMID 10322127 DOI: 10.1016/S1074-5521(99)80070-2  0.764
1999 Grozinger CM, Hassig CA, Schreiber SL. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proceedings of the National Academy of Sciences of the United States of America. 96: 4868-73. PMID 10220385 DOI: 10.1073/Pnas.96.9.4868  0.581
1999 Peterson RT, Desai BN, Hardwick JS, Schreiber SL. Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein. Proceedings of the National Academy of Sciences of the United States of America. 96: 4438-42. PMID 10200280 DOI: 10.1073/Pnas.96.8.4438  0.731
1999 Chen JK, Lane WS, Schreiber SL. The identification of myriocin-binding proteins. Chemistry & Biology. 6: 221-35. PMID 10099133 DOI: 10.1016/S1074-5521(99)80038-6  0.461
1999 Martinez EJ, Owa T, Schreiber SL, Corey EJ. Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743. Proceedings of the National Academy of Sciences of the United States of America. 96: 3496-501. PMID 10097064 DOI: 10.1073/Pnas.96.7.3496  0.452
1999 Stockwell BR, Haggarty SJ, Schreiber SL. High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications. Chemistry & Biology. 6: 71-83. PMID 10021420 DOI: 10.1016/S1074-5521(99)80004-0  0.699
1999 Hardwick JS, Tong JK, Schreiber SL. The transcriptional profile of Saccharomyces cerevisiae exposed to rapamycin mimics the profile induced by amino acid starvation Nature Genetics. 23: 49-49. DOI: 10.1038/14319  0.696
1999 Lee D, Sello JK, Schreiber SL. A strategy for macrocyclic ring closure and functionalization aimed toward split-pool syntheses [12] Journal of the American Chemical Society. 121: 10648-10649. DOI: 10.1021/Ja992658M  0.712
1999 Stockwell BR, Hardwick JS, Tong JK, Schreiber SL. Chemical genetic and genomic approaches reveal a role for copper in specific gene activation [19] Journal of the American Chemical Society. 121: 10662-10663. DOI: 10.1021/Ja9921221  0.758
1999 MacBeath G, Koehler AN, Schreiber SL. Printing small molecules as microarrays and detecting protein-ligand interactions en masse [19] Journal of the American Chemical Society. 121: 7967-7968. DOI: 10.1021/Ja991083Q  0.539
1999 McAlpine SR, Schreiber SL. Visualizing functional group distribution in solid-support beads by using optical analysis Chemistry - a European Journal. 5: 3528-3532. DOI: 10.1002/(Sici)1521-3765(19991203)5:12<3528::Aid-Chem3528>3.0.Co;2-4  0.55
1998 Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature. 395: 917-21. PMID 9804427 DOI: 10.1038/27699  0.693
1998 Stockwell BR, Schreiber SL. TGF-beta-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-beta type I receptor fusion proteins. Chemistry & Biology. 5: 385-95. PMID 9662508 DOI: 10.1016/S1074-5521(98)90072-2  0.46
1998 Stockwell BR, Schreiber SL. Probing the role of homomeric and heteromeric receptor interactions in TGF-beta signaling using small molecule dimerizers. Current Biology : Cb. 8: 761-70. PMID 9651680 DOI: 10.1016/S0960-9822(98)70299-4  0.443
1998 Chen J, Peterson RT, Schreiber SL. Alpha 4 associates with protein phosphatases 2A, 4, and 6. Biochemical and Biophysical Research Communications. 247: 827-32. PMID 9647778 DOI: 10.1006/Bbrc.1998.8792  0.496
1998 Peterson RT, Schreiber SL. Translation control: connecting mitogens and the ribosome. Current Biology : Cb. 8: R248-50. PMID 9545190 DOI: 10.1016/S0960-9822(98)70152-6  0.481
1998 Fenteany G, Schreiber SL. Lactacystin, proteasome function, and cell fate. The Journal of Biological Chemistry. 273: 8545-8. PMID 9535824 DOI: 10.1074/Jbc.273.15.8545  0.649
1998 Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Proceedings of the National Academy of Sciences of the United States of America. 95: 3519-24. PMID 9520398 DOI: 10.1073/Pnas.95.7.3519  0.726
1998 Kwon HJ, Owa T, Hassig CA, Shimada J, Schreiber SL. Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase. Proceedings of the National Academy of Sciences of the United States of America. 95: 3356-61. PMID 9520369 DOI: 10.1073/Pnas.95.7.3356  0.336
1998 Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL, Friend SH. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. The Embo Journal. 17: 159-69. PMID 9427750 DOI: 10.1093/Emboj/17.1.159  0.633
1998 Yang J, Symes K, Mercola M, Schreiber SL. Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment. Current Biology : Cb. 8: 11-8. PMID 9427627 DOI: 10.1016/S0960-9822(98)70015-6  0.385
1998 Huang J, Schreiber SL. A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanodroplets. Proceedings of the National Academy of Sciences of the United States of America. 94: 13396-401. PMID 9391035 DOI: 10.1073/Pnas.94.25.13396  0.382
1998 Shimada J, Kwon HJ, Sawamura M, Schreiber SL. Synthesis and cellular characterization of the detransformation agent, (-)-depudecin. Chemistry & Biology. 2: 517-25. PMID 9383455 DOI: 10.1016/1074-5521(95)90185-X  0.489
1998 Hung DT, Nerenberg JB, Schreiber SL. Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides. Chemistry & Biology. 1: 67-71. PMID 9383372 DOI: 10.1016/1074-5521(94)90042-6  0.556
1998 Tan DS, Foley MA, Shair MD, Schreiber SL. Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays [25] Journal of the American Chemical Society. 120: 8565-8566. DOI: 10.1021/Ja981746O  0.738
1998 Morken JP, Kapoor TM, Feng S, Shirai F, Schreiber SL. Exploring the leucine-proline binding pocket of the Src SH3 domain using structure-based, split-pool synthesis and affinity-based selection Journal of the American Chemical Society. 120: 30-36. DOI: 10.1021/Ja972729M  0.753
1998 Kapoor TM, Andreotti AH, Schreiber SL. Exploring the specificity pockets of two homologous SH3 domain using structure-based, split-pool synthesis and affinity-based selection Journal of the American Chemical Society. 120: 23-29. DOI: 10.1021/ja972728u  0.694
1998 Sternson SM, Schreiber SL. An acid- and base-stable o-nitrobenzyl photolabile linker for solid phase organic synthesis Tetrahedron Letters. 39: 7451-7454. DOI: 10.1016/S0040-4039(98)01668-2  0.611
1997 Borchardt A, Liberles SD, Biggar SR, Crabtree GR, Schreiber SL. Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale. Chemistry & Biology. 4: 961-8. PMID 9427663 DOI: 10.1016/S1074-5521(97)90304-5  0.679
1997 You AJ, Jackman RJ, Whitesides GM, Schreiber SL. A miniaturized arrayed assay format for detecting small molecule-protein interactions in cells. Chemistry & Biology. 4: 969-75. PMID 9427662 DOI: 10.1016/S1074-5521(97)90305-7  0.816
1997 Hassig CA, Tong JK, Schreiber SL. Fiber-derived butyrate and the prevention of colon cancer. Chemistry & Biology. 4: 783-9. PMID 9384528 DOI: 10.1016/S1074-5521(97)90111-3  0.703
1997 Liberles SD, Diver ST, Austin DJ, Schreiber SL. Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen. Proceedings of the National Academy of Sciences of the United States of America. 94: 7825-30. PMID 9223271 DOI: 10.1073/Pnas.94.15.7825  0.809
1997 Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell. 89: 373-80. PMID 9150137 DOI: 10.1016/S0092-8674(00)80218-4  0.309
1997 Zheng XF, Schreiber SL. Target of rapamycin proteins and their kinase activities are required for meiosis. Proceedings of the National Academy of Sciences of the United States of America. 94: 3070-5. PMID 9096347 DOI: 10.1073/Pnas.94.7.3070  0.33
1997 Andreotti AH, Bunnell SC, Feng S, Berg LJ, Schreiber SL. Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature. 385: 93-7. PMID 8985255 DOI: 10.1038/385093A0  0.594
1997 Hung DT, Chen J, Schreiber SL. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chemistry & Biology. 3: 287-93. PMID 8807856 DOI: 10.1016/S1074-5521(96)90108-8  0.555
1997 Feng S, Schreiber SL. Enantiomeric Binding Elements Interacting at the Same Site of an SH3 Protein Receptor Journal of the American Chemical Society. 119: 10873-10874. DOI: 10.1021/Ja972255R  0.306
1997 Jamison TF, Shambayati S, Crowe WE, Schreiber SL. Tandem use of cobalt-mediated reactions to synthesize (+)- epoxydictymene, a diterpene containing a trans-fused 5-5 ring system Journal of the American Chemical Society. 119: 4353-4363. DOI: 10.1021/Ja970022U  0.474
1997 Diver ST, Schreiber SL. Single-step synthesis of cell-permeable protein dimerizers that activate signal transduction and gene expression Journal of the American Chemical Society. 119: 5106-5109. DOI: 10.1021/Ja963891C  0.677
1997 Belshaw PJ, Schreiber SL. Cell-Specific Calcineurin Inhibition by a Modified Cyclosporin Journal of the American Chemical Society. 119: 1805-1806. DOI: 10.1021/Ja9636146  0.719
1996 Crabtree GR, Schreiber SL. Three-part inventions: intracellular signaling and induced proximity. Trends in Biochemical Sciences. 21: 418-22. PMID 8987395 DOI: 10.1016/S0968-0004(96)20027-1  0.324
1996 Freiberg RA, Spencer DM, Choate KA, Peng PD, Schreiber SL, Crabtree GR, Khavari PA. Specific triggering of the Fas signal transduction pathway in normal human keratinocytes. The Journal of Biological Chemistry. 271: 31666-9. PMID 8940187 DOI: 10.1074/Jbc.271.49.31666  0.319
1996 Fenteany G, Schreiber SL. Specific inhibition of the chymotrypsin-like activity of the proteasome induces a bipolar morphology in neuroblastoma cells. Chemistry & Biology. 3: 905-12. PMID 8939705 DOI: 10.1016/S1074-5521(96)90179-9  0.674
1996 Belshaw PJ, Spencer DM, Crabtree GR, Schreiber SL. Controlling programmed cell death with a cyclophilin-cyclosporin-based chemical inducer of dimerization. Chemistry & Biology. 3: 731-8. PMID 8939689 DOI: 10.1016/S1074-5521(96)90249-5  0.674
1996 Weiss GA, Valentekovich RJ, Collins EJ, Garboczi DN, Lane WS, Schreiber SL, Wiley DC. Covalent HLA-B27/peptide complex induced by specific recognition of an aziridine mimic of arginine. Proceedings of the National Academy of Sciences of the United States of America. 93: 10945-8. PMID 8855288 DOI: 10.1073/Pnas.93.20.10945  0.575
1996 Feng S, Kapoor TM, Shirai F, Combs AP, Schreiber SL. Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis. Chemistry & Biology. 3: 661-70. PMID 8807900 DOI: 10.1016/S1074-5521(96)90134-9  0.507
1996 Hung DT, Jamison TF, Schreiber SL. Understanding and controlling the cell cycle with natural products. Chemistry & Biology. 3: 623-39. PMID 8807895 DOI: 10.1016/S1074-5521(96)90129-5  0.669
1996 Spencer DM, Belshaw PJ, Chen L, Ho SN, Randazzo F, Crabtree GR, Schreiber SL. Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization. Current Biology : Cb. 6: 839-47. PMID 8805308 DOI: 10.1016/S0960-9822(02)00607-3  0.66
1996 Ho SN, Biggar SR, Spencer DM, Schreiber SL, Crabtree GR. Dimeric ligands define a role for transcriptional activation domains in reinitiation. Nature. 382: 822-6. PMID 8752278 DOI: 10.1038/382822A0  0.304
1996 Choi J, Chen J, Schreiber SL, Clardy J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science (New York, N.Y.). 273: 239-42. PMID 8662507 DOI: 10.1126/Science.273.5272.239  0.444
1996 Belshaw PJ, Ho SN, Crabtree GR, Schreiber SL. Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins. Proceedings of the National Academy of Sciences of the United States of America. 93: 4604-7. PMID 8643450 DOI: 10.1073/Pnas.93.10.4604  0.694
1996 Crews CM, Lane WS, Schreiber SL. Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis. Proceedings of the National Academy of Sciences of the United States of America. 93: 4316-9. PMID 8633062 DOI: 10.1073/Pnas.93.9.4316  0.548
1996 Cimprich KA, Shin TB, Keith CT, Schreiber SL. cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proceedings of the National Academy of Sciences of the United States of America. 93: 2850-5. PMID 8610130 DOI: 10.1073/Pnas.93.7.2850  0.789
1996 Taunton J, Hassig CA, Schreiber SL. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science (New York, N.Y.). 272: 408-11. PMID 8602529 DOI: 10.1126/Science.272.5260.408  0.494
1996 Taunton J, Collins JL, Schreiber SL. Synthesis of natural and modified trapoxins, useful reagents for exploring histone deacetylase function Journal of the American Chemical Society. 118: 10412-10422. DOI: 10.1021/Ja9615841  0.5
1996 Hung DT, Nerenberg JB, Schreiber SL. Syntheses of Discodermolides Useful for Investigating Microtubule Binding and Stabilization Journal of the American Chemical Society. 118: 11054-11080. DOI: 10.1021/Ja961374O  0.564
1996 Combs AP, Kapoor TM, Feng S, Chen JK, Daudé-Snow LF, Schreiber SL. Protein structure-based combinatorial chemistry: Discovery of non-peptide binding elements to Src SH3 domain Journal of the American Chemical Society. 118: 287-288. DOI: 10.1021/Ja953750V  0.663
1996 Liang J, Hung DT, Schreiber SL, Clardy J. Structure of the Human 25 kDa FK506 Binding Protein Complexed with Rapamycin Journal of the American Chemical Society. 118: 1231-1232. DOI: 10.1021/Ja953139W  0.562
1995 Weiss GA, Collins EJ, Garboczi DN, Wiley DC, Schreiber SL. A tricyclic ring system replaces the variable regions of peptides presented by three alleles of human MHC class I molecules. Chemistry & Biology. 2: 401-7. PMID 9383442 DOI: 10.1016/1074-5521(95)90221-X  0.561
1995 Feng S, Kasahara C, Rickles RJ, Schreiber SL. Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands. Proceedings of the National Academy of Sciences of the United States of America. 92: 12408-15. PMID 8618911 DOI: 10.1073/Pnas.92.26.12408  0.785
1995 Fenteany G, Standaert RF, Lane WS, Choi S, Corey EJ, Schreiber SL. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science (New York, N.Y.). 268: 726-31. PMID 7732382 DOI: 10.1126/Science.7732382  0.793
1995 Yu H, Schreiber SL. Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4. Biochemistry. 34: 9103-10. PMID 7619808 DOI: 10.1021/Bi00028A020  0.316
1995 Keith CT, Schreiber SL. PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science (New York, N.Y.). 270: 50-1. PMID 7569949 DOI: 10.1126/Science.270.5233.50  0.727
1995 Holsinger LJ, Spencer DM, Austin DJ, Schreiber SL, Crabtree GR. Signal transduction in T lymphocytes using a conditional allele of Sos. Proceedings of the National Academy of Sciences of the United States of America. 92: 9810-4. PMID 7568223 DOI: 10.1073/Pnas.92.21.9810  0.523
1995 Spencer DM, Graef I, Austin DJ, Schreiber SL, Crabtree GR. A general strategy for producing conditional alleles of Src-like tyrosine kinases. Proceedings of the National Academy of Sciences of the United States of America. 92: 9805-9. PMID 7568222 DOI: 10.1073/Pnas.92.21.9805  0.535
1995 Brown EJ, Beal PA, Keith CT, Chen J, Shin TB, Schreiber SL. Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature. 377: 441-6. PMID 7566123 DOI: 10.1038/377441A0  0.79
1995 Chen J, Zheng XF, Brown EJ, Schreiber SL. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proceedings of the National Academy of Sciences of the United States of America. 92: 4947-51. PMID 7539137 DOI: 10.1073/Pnas.92.11.4947  0.318
1995 Brown EJ, Beal PA, Keith CT, Chen J, Shin TB, Schreiber SL. Erratum: Control of p70 S6 kinase by kinase activity of FRAP in vivo Nature. 378: 644-644. DOI: 10.1038/378644C0  0.77
1995 Valentekovich RJ, Schreiber SL. Enantiospecific total synthesis of the protein phosphatase inhibitor motuporin. Journal of the American Chemical Society. 117: 9069-9070. DOI: 10.1021/Ja00140A025  0.319
1995 Belshaw PJ, Schoepfer JG, Liu K, Morrison KL, Schreiber SL. Rational Design of Orthogonal Receptor–Ligand Combinations Angewandte Chemie International Edition in English. 34: 2129-2132. DOI: 10.1002/anie.199521291  0.613
1995 Chen JK, Schreiber SL. Combinatorial Synthesis and Multidimensional NMR Spectroscopy: An Approach to Understanding Protein–Ligand Interactions Angewandte Chemie International Edition in English. 34: 953-969. DOI: 10.1002/Anie.199509531  0.477
1995 Belshaw PJ, Schoepfer JG, Liu K, Morrison KL, Schreiber SL. Rationales Design neuer Rezeptor-Ligand-Kombinationen Angewandte Chemie. 107: 2313-2317. DOI: 10.1002/ange.19951071920  0.617
1995 Chen JK, Schreiber SL. Kombinatorische Synthese und mehrdimensionale NMR-Spektroskopie: ein Beitrag zum Verständnis von Protein-Ligand-Wechselwirkungen Angewandte Chemie. 107: 1041-1058. DOI: 10.1002/Ange.19951070904  0.395
1994 Pruschy MN, Spencer DM, Kapoor TM, Miyake H, Crabtree GR, Schreiber SL. Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012. Chemistry & Biology. 1: 163-72. PMID 9383386 DOI: 10.1016/1074-5521(94)90006-X  0.534
1994 Austin DJ, Crabtree GR, Schreiber SL. Proximity versus allostery: the role of regulated protein dimerization in biology. Chemistry & Biology. 1: 131-6. PMID 9383382 DOI: 10.1016/1074-5521(94)90002-7  0.499
1994 Crews CM, Collins JL, Lane WS, Snapper ML, Schreiber SL. GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha. The Journal of Biological Chemistry. 269: 15411-4. PMID 8195179  0.686
1994 Fenteany G, Standaert RF, Reichard GA, Corey EJ, Schreiber SL. A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 91: 3358-62. PMID 8159752 DOI: 10.1073/Pnas.91.8.3358  0.8
1994 Ke H, Mayrose D, Belshaw PJ, Alberg DG, Schreiber SL, Chang ZY, Etzkorn FA, Ho S, Walsh CT. Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A. Structure (London, England : 1993). 2: 33-44. PMID 8075981 DOI: 10.1016/S0969-2126(00)00006-X  0.791
1994 Luan S, Lane WS, Schreiber SL. pCyP B: a chloroplast-localized, heat shock-responsive cyclophilin from fava bean. The Plant Cell. 6: 885-92. PMID 8061522 DOI: 10.1105/Tpc.6.6.885  0.319
1994 Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, Schreiber SL. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature. 369: 756-8. PMID 8008069 DOI: 10.1038/369756A0  0.758
1994 Ho SN, Boyer SH, Schreiber SL, Danishefsky SJ, Crabtree GR. Specific inhibition of formation of transcription complexes by a calicheamicin oligosaccharide: a paradigm for the development of transcriptional antagonists. Proceedings of the National Academy of Sciences of the United States of America. 91: 9203-7. PMID 7937742 DOI: 10.1073/Pnas.91.20.9203  0.47
1994 Feng S, Chen JK, Yu H, Simon JA, Schreiber SL. Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions. Science (New York, N.Y.). 266: 1241-7. PMID 7526465 DOI: 10.1126/Science.7526465  0.467
1994 Tai PK, Albers MW, McDonnell DP, Chang H, Schreiber SL, Faber LE. Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. Biochemistry. 33: 10666-71. PMID 7521210 DOI: 10.1021/Bi00201A014  0.319
1994 Yu H, Chen JK, Feng S, Dalgarno DC, Brauer AW, Schreiber SL. Structural basis for the binding of proline-rich peptides to SH3 domains. Cell. 76: 933-45. PMID 7510218 DOI: 10.1016/0092-8674(94)90367-0  0.408
1994 Belshaw PJ, Meyer SD, Johnson DD, Romo D, Ikeda Y, Andrus M, Alberg DG, Schultz LW, Clardy J, Schreiber SL. Synthesis, Structure and Mechanism in Immunophilin Research Synlett. 1994: 381-392. DOI: 10.1055/S-1994-22863  0.77
1994 Gomez FA, Chen JK, Tanaka A, Schreiber SL, Whitesides GM. Affinity Capillary Electrophoresis: Insights into the Binding of SH3 Domains by Peptides Derived from an SH3-Binding Protein The Journal of Organic Chemistry. 59: 2885-2886. DOI: 10.1021/Jo00089A038  0.461
1994 Jamison TF, Shambayati S, Crowe WE, Schreiber SL. Cobalt-mediated total synthesis of (+)-epoxydictymene Journal of the American Chemical Society. 116: 5505-5506. DOI: 10.1021/Ja00091A079  0.481
1994 Chen JK, Schreiber SL. SH3 domain-mediated dimerization of an n-terminal fragment of the phosphatidylinositol 3-kinase p85 subunit Bioorganic & Medicinal Chemistry Letters. 4: 1755-1760. DOI: 10.1016/S0960-894X(00)80375-3  0.459
1994 Schreiber SL, Crabtree GR. Regulated intracellular association of proteins using cell-permeable synthetic ligands Chemistry & Biology. 1: xx-xxi. DOI: 10.1016/1074-5521(94)90027-2  0.317
1993 Yu H, Rosen MK, Schreiber SL. 1H and 15N assignments and secondary structure of the Src SH3 domain. Febs Letters. 324: 87-92. PMID 8504863 DOI: 10.1016/0014-5793(93)81538-B  0.504
1993 Yu H, Rosen MK, Saccomano NA, Phillips D, Volkmann RA, Schreiber SL. Sequential assignment and structure determination of spider toxin omega-Aga-IVB. Biochemistry. 32: 13123-9. PMID 8241166 DOI: 10.1021/Bi00211A022  0.533
1993 Alberg DG, Schreiber SL. Structure-based design of a cyclophilin-calcineurin bridging ligand. Science (New York, N.Y.). 262: 248-50. PMID 8211144 DOI: 10.1126/Science.8211144  0.74
1993 Spencer DM, Wandless TJ, Schreiber SL, Crabtree GR. Controlling signal transduction with synthetic ligands. Science (New York, N.Y.). 262: 1019-24. PMID 7694365 DOI: 10.1126/Science.7694365  0.639
1993 Lyson T, Ermel LD, Belshaw PJ, Alberg DG, Schreiber SL, Victor RG. Cyclosporine- and FK506-induced sympathetic activation correlates with calcineurin-mediated inhibition of T-cell signaling. Circulation Research. 73: 596-602. PMID 7688670  0.794
1993 Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR. Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Molecular and Cellular Biology. 13: 4760-9. PMID 7687744 DOI: 10.1128/Mcb.13.8.4760  0.557
1993 Koyama S, Yu H, Dalgarno DC, Shin TB, Zydowsky LD, Schreiber SL. 1H and 15N assignments and secondary structure of the PI3K SH3 domain. Febs Letters. 324: 93-8. PMID 7684988 DOI: 10.1016/0014-5793(93)81539-C  0.469
1993 Koyama S, Yu H, Dalgarno DC, Shin TB, Zydowsky LD, Schreiber SL. Structure of the PI3K SH3 domain and analysis of the SH3 family. Cell. 72: 945-52. PMID 7681364 DOI: 10.1016/0092-8674(93)90582-B  0.491
1993 Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy J. Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin Journal of Molecular Biology. 229: 105-124. PMID 7678431 DOI: 10.1006/Jmbi.1993.1012  0.633
1993 Nerenberg JB, Hung DT, Somers PK, Schreiber SL. Total synthesis of the immunosuppressive agent (-)-discodermolide Journal of the American Chemical Society. 115: 12621-12622. DOI: 10.1021/Ja00079A066  0.487
1993 Chen JK, Lane WS, Brauer AW, Tanaka A, Schreiber SL. Biased combinatorial libraries: novel ligands for the SH3 domain of phosphatidylinositol 3-kinase Journal of the American Chemical Society. 115: 12591-12592. DOI: 10.1021/Ja00079A051  0.471
1993 Andrus MB, Schreiber SL. Structure-based design of an acyclic ligand that bridges FKBP12 and calcineurin Journal of the American Chemical Society. 115: 10420-10421. DOI: 10.1021/Ja00075A092  0.591
1993 Taunton J, Wood JL, Schreiber SL. Total syntheses of di- and tri-O-methyl dynemicin A methyl esters Journal of the American Chemical Society. 115: 10378-10379. DOI: 10.1021/Ja00075A071  0.623
1993 Romo D, Meyer SD, Johnson DD, Schreiber SL. Total synthesis of (-)-rapamycin using an Evans-Tishchenko fragment coupling Journal of the American Chemical Society. 115: 7906-7907. DOI: 10.1021/Ja00070A058  0.533
1993 Delfino JM, Schreiber SL, Richards FM. Design, synthesis, and properties of a photoactivatable membrane-spanning phospholipidic probe Journal of the American Chemical Society. 115: 3458-3474. DOI: 10.1021/Ja00062A009  0.544
1993 Poss CS, Rychnovsky SD, Schreiber SL. Two-directional chain synthesis: An application to the synthesis of (+)-mycoticin A Journal of the American Chemical Society. 115: 3360-3361. DOI: 10.1021/Ja00061A057  0.452
1993 Rosen MK, Yang D, Martin PK, Schreiber SL. Activation of an inactive immunophilin by mutagenesis Journal of the American Chemical Society. 115: 821-822. DOI: 10.1021/Ja00055A082  0.557
1993 Yang D, Rosen MK, Schreiber SL. A composite FKBP12-FK506 surface that contacts calcineurin Journal of the American Chemical Society. 115: 819-820. DOI: 10.1021/Ja00055A081  0.524
1992 Kaye RE, Fruman DA, Bierer BE, Albers MW, Zydowsky LD, Ho SI, Jin YJ, Castells MC, Schreiber SL, Walsh CT. Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12. Proceedings of the National Academy of Sciences of the United States of America. 89: 8542-6. PMID 1382293 DOI: 10.1073/Pnas.89.18.8542  0.424
1992 Hung DT, Schreiber SL. cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. Biochemical and Biophysical Research Communications. 184: 733-8. PMID 1374240 DOI: 10.1016/0006-291X(92)90651-Z  0.573
1992 Liu J, Albers MW, Wandless TJ, Luan S, Alberg DG, Belshaw PJ, Cohen P, MacKintosh C, Klee CB, Schreiber SL. Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. Biochemistry. 31: 3896-901. PMID 1373650 DOI: 10.1021/Bi00131A002  0.806
1992 Galat A, Lane WS, Standaert RF, Schreiber SL. A rapamycin-selective 25-kDa immunophilin Biochemistry. 31: 2427-2434. PMID 1371698 DOI: 10.1021/Bi00123A031  0.639
1992 Yu H, Rosen MK, Shin TB, Seidel-Dugan C, Brugge JS, Schreiber SL. Solution structure of the SH3 domain of Src and identification of its ligand-binding site Science. 258: 1665-1668. PMID 1280858 DOI: 10.1126/Science.1280858  0.537
1992 Romo D, Johnson DD, Plamondon L, Miwa T, Schreiber SL. Synthetic investigations of rapamycin. 2. Synthesis of a C(22)-C(42) fragment The Journal of Organic Chemistry. 57: 5060-5063. DOI: 10.1021/Jo00045A008  0.514
1992 Wood JL, Porco JA, Taunton J, Lee AY, Clardy J, Schreiber SL. Application of the allylic diazene rearrangement: synthesis of the enediyne-bridged tricyclic core of dynemicin A Journal of the American Chemical Society. 114: 5898-5900. DOI: 10.1021/Ja00040A085  0.646
1992 Rosen MK, Belshaw PJ, Alberg DG, Schreiber SL. The conformation of cyclosporin a bound to cyclophilin is altered (once again) following binding to calcineurin: an analysis of receptor-ligand-receptor interactions Bioorganic and Medicinal Chemistry Letters. 2: 747-753. DOI: 10.1016/S0960-894X(00)80405-9  0.789
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