| Year |
Citation |
Score |
| 2021 |
Flagstad T, Pedersen MT, Jakobsen TH, Felding J, Tolker-Nielsen T, Givskov M, Qvortrup K, Nielsen TE. Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors. Bioorganic & Medicinal Chemistry Letters. 57: 128499. PMID 34906671 DOI: 10.1016/j.bmcl.2021.128499 |
0.321 |
|
| 2019 |
Wu P, Givskov M, Nielsen TE. Reactivity and Synthetic Applications of Multicomponent Petasis Reactions. Chemical Reviews. PMID 31454230 DOI: 10.1021/Acs.Chemrev.9B00214 |
0.43 |
|
| 2018 |
Wu P, Nielsen TE. Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds. Drug Discovery Today. Technologies. 29: 27-33. PMID 30471670 DOI: 10.1016/J.Ddtec.2018.06.010 |
0.474 |
|
| 2017 |
Bang C, Jensen J, Cohrt E, Olsen L, Siyum S, Mortensen K, Poulsen TS, Berthelsen J, Yang L, Givskov M, Qvortrup K, Nielsen TE. Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC Inhibitors Using a Chemi-luminescence-based Assay. Acs Combinatorial Science. PMID 28746804 DOI: 10.1021/acscombsci.7b00068 |
0.361 |
|
| 2017 |
Ishoey M, Petersen RG, Petersen MÅ, Wu P, Clausen MH, Nielsen TE. Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels-Alder and ROM-RCM reactions. Chemical Communications (Cambridge, England). PMID 28714998 DOI: 10.1039/C7Cc02948A |
0.435 |
|
| 2017 |
Wu P, Nielsen TE. Scaffold Diversity from N-Acyliminium Ions. Chemical Reviews. PMID 28493667 DOI: 10.1021/Acs.Chemrev.6B00806 |
0.352 |
|
| 2016 |
Hansen CL, Ohm RG, Olsen LB, Ascic E, Tanner DA, Nielsen TE. Catalytic Enantioselective Synthesis of Tetrahydocarbazoles and Exocyclic Pictet-Spengler-Type Reactions. Organic Letters. 18: 5990-5993. PMID 27934390 DOI: 10.1021/Acs.Orglett.6B02718 |
0.323 |
|
| 2016 |
Wu P, Petersen MÅ, Cohrt AE, Petersen R, Morgentin R, Lemoine H, Roche C, Willaume A, Clausen MH, Nielsen TE. A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production. Organic & Biomolecular Chemistry. PMID 27356738 DOI: 10.1039/C6Ob01148A |
0.43 |
|
| 2015 |
Wu P, Clausen MH, Nielsen TE. Allosteric small-molecule kinase inhibitors. Pharmacology & Therapeutics. PMID 26478442 DOI: 10.1016/J.Pharmthera.2015.10.002 |
0.346 |
|
| 2015 |
Wu P, Nielsen TE, Clausen MH. Small-molecule kinase inhibitors: an analysis of FDA-approved drugs. Drug Discovery Today. PMID 26210956 DOI: 10.1016/J.Drudis.2015.07.008 |
0.35 |
|
| 2015 |
Flagstad T, Petersen MT, Nielsen TE. A Four-Component Reaction for the Synthesis of Dioxadiazaborocines. Angewandte Chemie (International Ed. in English). 54: 8395-7. PMID 26068978 DOI: 10.1002/anie.201502989 |
0.303 |
|
| 2015 |
Wu P, Nielsen TE, Clausen MH. FDA-approved small-molecule kinase inhibitors. Trends in Pharmacological Sciences. 36: 422-39. PMID 25975227 DOI: 10.1016/J.Tips.2015.04.005 |
0.346 |
|
| 2015 |
Hansen MR, Jakobsen TH, Bang CG, Cohrt AE, Hansen CL, Clausen JW, Le Quement ST, Tolker-Nielsen T, Givskov M, Nielsen TE. Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa. Bioorganic & Medicinal Chemistry. 23: 1638-50. PMID 25716005 DOI: 10.1016/j.bmc.2015.01.038 |
0.317 |
|
| 2015 |
Petersen R, Cohrt AE, Petersen MÅ, Wu P, Clausen MH, Nielsen TE. Synthesis of hexahydropyrrolo[2,1-a]isoquinoline compound libraries through a Pictet-Spengler cyclization/metal-catalyzed cross coupling/amidation sequence. Bioorganic & Medicinal Chemistry. 23: 2646-9. PMID 25703308 DOI: 10.1016/J.Bmc.2015.01.039 |
0.429 |
|
| 2015 |
Petersen MÅ, Mortensen MA, Cohrt AE, Petersen R, Wu P, Fleury-Brégeot N, Morgentin R, Lardy C, Nielsen TE, Clausen MH. Synthesis of 1,4,5 trisubstituted γ-lactams via a 3-component cascade reaction. Bioorganic & Medicinal Chemistry. 23: 2695-8. PMID 25684425 DOI: 10.1016/J.Bmc.2015.01.041 |
0.457 |
|
| 2013 |
Hansen CL, Clausen JW, Ohm RG, Ascic E, Le Quement ST, Tanner D, Nielsen TE. Ruthenium hydride/Brønsted acid-catalyzed tandem isomerization/N-acyliminium cyclization sequence for the synthesis of tetrahydro-β-carbolines. The Journal of Organic Chemistry. 78: 12545-65. PMID 24180610 DOI: 10.1021/Jo402192S |
0.312 |
|
| 2013 |
Stacy DM, Le Quement ST, Hansen CL, Clausen JW, Tolker-Nielsen T, Brummond JW, Givskov M, Nielsen TE, Blackwell HE. Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators. Organic & Biomolecular Chemistry. 11: 938-54. PMID 23258305 DOI: 10.1039/C2Ob27155A |
0.484 |
|
| 2010 |
Nielsen TE, Meldal M. Solid-phase synthesis of complex and pharmacologically interesting heterocycles. Current Opinion in Drug Discovery & Development. 12: 798-810. PMID 19894191 |
0.315 |
|
| 2008 |
Quement STL, Nielsen TE, Meldal M. Solid-Phase Synthesis of Aryl-Substituted Thienoindolizines: Sequential Pictet−Spengler, Bromination and Suzuki Cross-Coupling Reactions of Thiophenes Acs Combinatorial Science. 10: 447-455. PMID 18386932 DOI: 10.1021/Cc700199N |
0.319 |
|
| 2008 |
Nielsen TE, Schreiber SL. Towards the optimal screening collection: a synthesis strategy. Angewandte Chemie (International Ed. in English). 47: 48-56. PMID 18080276 DOI: 10.1002/anie.200703073 |
0.424 |
|
| 2007 |
Quement STL, Nielsen TE, Meldal M. Scaffold diversity through intramolecular cascade reactions of solid-supported cyclic N-acyliminium intermediates. Acs Combinatorial Science. 9: 1060-1072. PMID 17994787 DOI: 10.1021/Cc700097K |
0.31 |
|
| 2006 |
Juhl M, Nielsen TE, Quement SL, Tanner D. Synthesis of the zoanthamine ABC ring system: some surprises from intramolecular Diels-Alder reactions. Journal of Organic Chemistry. 71: 265-280. PMID 16388646 DOI: 10.1021/Jo0520691 |
0.346 |
|
| 2004 |
Nielsen TE, Meldal M. Solid-Phase Intramolecular N-Acyliminium Pictet−Spengler Reactions as Crossroads to Scaffold Diversity Journal of Organic Chemistry. 69: 3765-3773. PMID 15153007 DOI: 10.1021/Jo049918P |
0.328 |
|
| 2003 |
Nielsen TE, Diness F, Meldal M. The Pictet-Spengler reaction in solid-phase combinatorial chemistry. Current Opinion in Drug Discovery & Development. 6: 801-14. PMID 14758752 |
0.312 |
|
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