| Year |
Citation |
Score |
| 2012 |
Rui Z, Ye M, Wang S, Fujikawa K, Akerele B, Aung M, Floss HG, Zhang W, Yu TW. Insights into a divergent phenazine biosynthetic pathway governed by a plasmid-born esmeraldin gene cluster. Chemistry & Biology. 19: 1116-25. PMID 22999880 DOI: 10.1016/J.Chembiol.2012.07.025 |
0.397 |
|
| 2012 |
Eichner S, Eichner T, Floss HG, Fohrer J, Hofer E, Sasse F, Zeilinger C, Kirschning A. Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin. Journal of the American Chemical Society. 134: 1673-9. PMID 22136518 DOI: 10.1021/Ja2087147 |
0.596 |
|
| 2012 |
Eichner S, Knobloch T, Floss HG, Fohrer J, Harmrolfs K, Hermane J, Schulz A, Sasse F, Spiteller P, Taft F, Kirschning A. The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library. Angewandte Chemie (International Ed. in English). 51: 752-7. PMID 22135226 DOI: 10.1002/Anie.201106249 |
0.422 |
|
| 2011 |
Wu Y, Kang Q, Shang G, Spiteller P, Carroll B, Yu TW, Su W, Bai L, Floss HG. N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis. Chembiochem : a European Journal of Chemical Biology. 12: 1759-66. PMID 21681880 DOI: 10.1002/Cbic.201100062 |
0.579 |
|
| 2011 |
Floss HG, Yu TW, Arakawa K. The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review. The Journal of Antibiotics. 64: 35-44. PMID 21081954 DOI: 10.1038/Ja.2010.139 |
0.421 |
|
| 2010 |
Harmrolfs K, Brünjes M, Dräger G, Floss HG, Sasse F, Taft F, Kirschning A. Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst. Chembiochem : a European Journal of Chemical Biology. 11: 2517-20. PMID 21077088 DOI: 10.1002/Cbic.201000422 |
0.592 |
|
| 2010 |
Rui Z, Petrícková K, Skanta F, Pospísil S, Yang Y, Chen CY, Tsai SF, Floss HG, Petrícek M, Yu TW. Biochemical and genetic insights into asukamycin biosynthesis. The Journal of Biological Chemistry. 285: 24915-24. PMID 20522559 DOI: 10.1074/Jbc.M110.128850 |
0.409 |
|
| 2010 |
Floss H, Leistner E. Obituary – Professor Dr. Detlef Gröger Planta Medica. 76: 1389-1389. DOI: 10.1055/S-0030-1250262 |
0.532 |
|
| 2010 |
Hu Y, Floss HG. ChemInform Abstract: New Type II Manumycins Produced by Streptomyces nodosus ssp. asukaensis and Their Biosynthesis. Cheminform. 32: no-no. DOI: 10.1002/chin.200139238 |
0.685 |
|
| 2009 |
Eichner S, Floss HG, Sasse F, Kirschning A. New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis. Chembiochem : a European Journal of Chemical Biology. 10: 1801-5. PMID 19554593 DOI: 10.1002/Cbic.200900246 |
0.461 |
|
| 2009 |
Taft F, Brünjes M, Knobloch T, Floss HG, Kirschning A. Timing of the Delta(10,12)-Delta(11,13) double bond migration during ansamitocin biosynthesis in Actinosynnema pretiosum. Journal of the American Chemical Society. 131: 3812-3. PMID 19292483 DOI: 10.1021/Ja8088923 |
0.487 |
|
| 2008 |
Zhao P, Bai L, Ma J, Zeng Y, Li L, Zhang Y, Lu C, Dai H, Wu Z, Li Y, Wu X, Chen G, Hao X, Shen Y, Deng Z, ... Floss HG, et al. Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins. Chemistry & Biology. 15: 863-74. PMID 18721757 DOI: 10.1016/J.Chembiol.2008.06.007 |
0.319 |
|
| 2008 |
Taft F, Brünjes M, Floss HG, Czempinski N, Grond S, Sasse F, Kirschning A. Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant. Chembiochem : a European Journal of Chemical Biology. 9: 1057-60. PMID 18381586 DOI: 10.1002/Cbic.200700742 |
0.468 |
|
| 2007 |
Floss HG, Tsai MD, Woodard RW. Stereochemistry of biological reactions at proprochiral centers Topics in Stereochemistry. 253-321. DOI: 10.1002/9780470147245.Ch4 |
0.557 |
|
| 2006 |
Wenzel SC, Williamson RM, Grünanger C, Xu J, Gerth K, Martinez RA, Moss SJ, Carroll BJ, Grond S, Unkefer CJ, Müller R, Floss HG. On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A. Journal of the American Chemical Society. 128: 14325-36. PMID 17076505 DOI: 10.1021/Ja064408T |
0.619 |
|
| 2006 |
Kubota T, Brünjes M, Frenzel T, Xu J, Kirschning A, Floss HG. Determination of the cryptic stereochemistry of the first PKS chain-extension step in ansamitocin biosynthesis by Actinosynnema pretiosum. Chembiochem : a European Journal of Chemical Biology. 7: 1221-5. PMID 16927319 DOI: 10.1002/Cbic.200500506 |
0.562 |
|
| 2006 |
Bai L, Li L, Xu H, Minagawa K, Yu Y, Zhang Y, Zhou X, Floss HG, Mahmud T, Deng Z. Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A. Chemistry & Biology. 13: 387-97. PMID 16632251 DOI: 10.1016/J.Chembiol.2006.02.002 |
0.642 |
|
| 2005 |
Yu Y, Bai L, Minagawa K, Jian X, Li L, Li J, Chen S, Cao E, Mahmud T, Floss HG, Zhou X, Deng Z. Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis 5008. Applied and Environmental Microbiology. 71: 5066-76. PMID 16151088 DOI: 10.1128/Aem.71.9.5066-5076.2005 |
0.643 |
|
| 2005 |
Xu J, Wan E, Kim CJ, Floss HG, Mahmud T. Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699. Microbiology (Reading, England). 151: 2515-28. PMID 16079331 DOI: 10.1099/Mic.0.28138-0 |
0.652 |
|
| 2004 |
Hu Y, Floss HG. Further studies on the biosynthesis of the manumycin-type antibiotic, asukamycin, and the chemical synthesis of protoasukamycin. Journal of the American Chemical Society. 126: 3837-44. PMID 15038738 DOI: 10.1021/Ja039336+ |
0.758 |
|
| 2004 |
Cassady JM, Chan KK, Floss HG, Leistner E. Recent developments in the maytansinoid antitumor agents. Chemical & Pharmaceutical Bulletin. 52: 1-26. PMID 14709862 DOI: 10.1248/Cpb.52.1 |
0.565 |
|
| 2003 |
Spiteller P, Bai L, Shang G, Carroll BJ, Yu TW, Floss HG. The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum. Journal of the American Chemical Society. 125: 14236-7. PMID 14624546 DOI: 10.1021/Ja038166Y |
0.596 |
|
| 2003 |
Xu J, Mahmud T, Floss HG. Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699. Archives of Biochemistry and Biophysics. 411: 277-88. PMID 12623077 DOI: 10.1016/S0003-9861(03)00004-3 |
0.667 |
|
| 2003 |
Pullen CB, Schmitz P, Hoffmann D, Meurer K, Boettcher T, von Bamberg D, Pereira AM, de Castro França S, Hauser M, Geertsema H, van Wyk A, Mahmud T, Floss HG, Leistner E. Occurrence and non-detectability of maytansinoids in individual plants of the genera Maytenus and Putterlickia. Phytochemistry. 62: 377-87. PMID 12620351 DOI: 10.1016/S0031-9422(02)00550-2 |
0.71 |
|
| 2002 |
Arakawa K, Müller R, Mahmud T, Yu TW, Floss HG. Characterization of the early stage aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic acid: the RifN protein specifically converts kanosamine into kanosamine 6-phosphate. Journal of the American Chemical Society. 124: 10644-5. PMID 12207505 DOI: 10.1021/Ja0206339 |
0.725 |
|
| 2002 |
Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG. The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum. Proceedings of the National Academy of Sciences of the United States of America. 99: 7968-73. PMID 12060743 DOI: 10.1073/Pnas.092697199 |
0.637 |
|
| 2002 |
Moss SJ, Bai L, Toelzer S, Carroll BJ, Mahmud T, Yu TW, Floss HG. Identification of asm19 as an acyltransferase attaching the biologically essential ester side chain of ansamitocins using N-desmethyl-4,5-desepoxymaytansinol, not maytansinol, as its substrate. Journal of the American Chemical Society. 124: 6544-5. PMID 12047169 DOI: 10.1021/Ja020214B |
0.751 |
|
| 2002 |
Kato Y, Bai L, Xue Q, Revill WP, Yu TW, Floss HG. Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B. Journal of the American Chemical Society. 124: 5268-9. PMID 11996558 DOI: 10.1021/Ja0127483 |
0.322 |
|
| 2002 |
Carroll BJ, Moss SJ, Bai L, Kato Y, Toelzer S, Yu TW, Floss HG. Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual "glycolate" chain extension unit in ansamitocin biosynthesis. Journal of the American Chemical Society. 124: 4176-7. PMID 11960423 DOI: 10.1021/Ja0124764 |
0.623 |
|
| 2002 |
Bowers SG, Mahmud T, Floss HG. Biosynthetic studies on the alpha-glucosidase inhibitor acarbose: the chemical synthesis of dTDP-4-amino-4,6-dideoxy-alpha-D-glucose. Carbohydrate Research. 337: 297-304. PMID 11841810 DOI: 10.1016/S0008-6215(01)00323-8 |
0.646 |
|
| 2002 |
Keller PJ, Floss HG, Quang LVQLV, Schwarzkopf B, Bacher A. Biosynthesis of Methanopterin (I) in Methanobacterium thermoautotrophicum Cheminform. 17. DOI: 10.1002/Chin.198620330 |
0.337 |
|
| 2002 |
Dübeler A, Krastel P, Floss HG, Zeeck A. Biosynthesis of the antibiotic echinosporin by a novel branch of the shikimate pathway European Journal of Organic Chemistry. 983-987. DOI: 10.1002/1099-0690(200203)2002:6<983::Aid-Ejoc983>3.0.Co;2-M |
0.379 |
|
| 2001 |
Mahmud T, Lee S, Floss HG. The biosynthesis of acarbose and validamycin. Chemical Record (New York, N.Y.). 1: 300-10. PMID 11893070 DOI: 10.1002/Tcr.1015 |
0.646 |
|
| 2001 |
McDonald M, Mavrodi DV, Thomashow LS, Floss HG. Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid. Journal of the American Chemical Society. 123: 9459-60. PMID 11562236 DOI: 10.1021/Ja011243+ |
0.647 |
|
| 2001 |
Dong H, Mahmud T, Tornus I, Lee S, Floss HG. Biosynthesis of the validamycins: identification of intermediates in the biosynthesis of validamycin A by Streptomyces hygroscopicus var. limoneus. Journal of the American Chemical Society. 123: 2733-42. PMID 11456959 DOI: 10.1021/Ja003643N |
0.676 |
|
| 2001 |
Hu Y, Floss HG. New type II manumycins produced by Streptomyces nodosus ssp. asukaensis and their biosynthesis. The Journal of Antibiotics. 54: 340-8. PMID 11426658 DOI: 10.7164/Antibiotics.54.340 |
0.704 |
|
| 2001 |
Yu TW, Muller R, Muller M, Zhang X, Draeger G, Kim CG, Leistner E, Floss HG. Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699. The Journal of Biological Chemistry. 276: 12546-55. PMID 11278540 DOI: 10.1074/Jbc.M009667200 |
0.683 |
|
| 2001 |
Tornus D, Floss HG. Identification of four genes from the granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22 involved in the biosynthesis of L-rhodinose. The Journal of Antibiotics. 54: 91-101. PMID 11269719 DOI: 10.7164/Antibiotics.54.91 |
0.309 |
|
| 2001 |
Lowden PA, Wilkinson B, Böhm GA, Handa S, Floss HG, Leadlay PF, Staunton J. Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase We thank Dr. Bradley S. Moore for help with the deuterium NMR experiments. This work was supported by grants from The Wellcome Trust (to J.S. and P.F.L.) and from the NIH (AI20264 to H.G.F.). Angewandte Chemie (International Ed. in English). 40: 777-779. PMID 11241621 DOI: 10.1002/1521-3773(20010216)40:4<777::Aid-Anie7770>3.0.Co;2-9 |
0.716 |
|
| 2000 |
Williams DC, Carroll BJ, Jin Q, Rithner CD, Lenger SR, Floss HG, Coates RM, Williams RM, Croteau R. Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase. Chemistry & Biology. 7: 969-77. PMID 11137819 DOI: 10.1016/S1074-5521(00)00046-6 |
0.622 |
|
| 2000 |
Doi-Katayama Y, Yoon YJ, Choi CY, Yu TW, Floss HG, Hutchinson CR. Thioesterases and the premature termination of polyketide chain elongation in rifamycin B biosynthesis by Amycolatopsis mediterranei S699. The Journal of Antibiotics. 53: 484-95. PMID 10908112 DOI: 10.7164/Antibiotics.53.484 |
0.311 |
|
| 1999 |
Handa S, Koo JH, Kim YS, Floss HG. Stereochemical course of biotin-independent malonate decarboxylase catalysis. Archives of Biochemistry and Biophysics. 370: 93-6. PMID 10496981 DOI: 10.1006/Abbi.1999.1369 |
0.368 |
|
| 1999 |
Eads JC, Beeby M, Scapin G, Yu TW, Floss HG. Crystal structure of 3-amino-5-hydroxybenzoic acid (AHBA) synthase. Biochemistry. 38: 9840-9. PMID 10433690 DOI: 10.1021/Bi990018Q |
0.344 |
|
| 1999 |
Yu TW, Shen Y, Doi-Katayama Y, Tang L, Park C, Moore BS, Richard Hutchinson C, Floss HG. Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively. Proceedings of the National Academy of Sciences of the United States of America. 96: 9051-6. PMID 10430893 DOI: 10.1073/Pnas.96.16.9051 |
0.632 |
|
| 1999 |
Stratmann A, Mahmud T, Lee S, Distler J, Floss HG, Piepersberg W. The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose. The Journal of Biological Chemistry. 274: 10889-96. PMID 10196166 DOI: 10.1074/Jbc.274.16.10889 |
0.674 |
|
| 1999 |
Chen S, von Bamberg D, Hale V, Breuer M, Hardt B, Müller R, Floss HG, Reynolds KA, Leistner E. Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892. European Journal of Biochemistry / Febs. 261: 98-107. PMID 10103039 DOI: 10.1046/J.1432-1327.1999.00244.X |
0.67 |
|
| 1999 |
Shen Y, Yoon P, Yu TW, Floss HG, Hopwood D, Moore BS. Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes. Proceedings of the National Academy of Sciences of the United States of America. 96: 3622-7. PMID 10097087 DOI: 10.1073/Pnas.96.7.3622 |
0.658 |
|
| 1999 |
McDonald M, Wilkinson B, Van't Land CW, Mocek U, Lee S, Floss HG. Biosynthesis of phenazine antibiotics in Streptomyces antibioticus: Stereochemistry of methyl transfer from carbon-2 of acetate Journal of the American Chemical Society. 121: 5619-5624. DOI: 10.1021/Ja991159I |
0.694 |
|
| 1999 |
Mahmud T, Tornus I, Egelkrout E, Wolf E, Uy C, Floss HG, Lee S. Biosynthetic studies on the α-glucosidase inhibitor acarbose in Actinoplanes sp.: 2-epi-5-epi-valiolone is the direct precursor of the valienamine moiety Journal of the American Chemical Society. 121: X. DOI: 10.1021/Ja991102W |
0.675 |
|
| 1999 |
Lee S, Kirschning A, Müller M, Way C, Floss HG. Enzymatic synthesis of [7-14C, 7-3H]- and [1-13C]sedoheptulose 7- phosphate and [1-13C]ido-heptulose 7-phosphate Journal of Molecular Catalysis - B Enzymatic. 6: 369-377. DOI: 10.1016/S1381-1177(98)00131-3 |
0.554 |
|
| 1998 |
Ichinose K, Bedford DJ, Tornus D, Bechthold A, Bibb MJ, Revill WP, Floss HG, Hopwood DA. The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22: sequence analysis and expression in a heterologous host. Chemistry & Biology. 5: 647-59. PMID 9831526 DOI: 10.1016/S1074-5521(98)90292-7 |
0.31 |
|
| 1998 |
Takeda Y, Masuda T, Matsumoto T, Takechi Y, Shingu T, Floss HG. Nuclear magnetic resonance and biosynthetic studies of neoantimycin and structure elucidation of isoneoantimycin, a minor metabolite related to neoantimycin. Journal of Natural Products. 61: 978-81. PMID 9722479 DOI: 10.1021/Np9800194 |
0.367 |
|
| 1998 |
August PR, Tang L, Yoon YJ, Ning S, Müller R, Yu TW, Taylor M, Hoffmann D, Kim CG, Zhang X, Hutchinson CR, Floss HG. Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699. Chemistry & Biology. 5: 69-79. PMID 9512878 DOI: 10.1016/S1074-5521(98)90141-7 |
0.474 |
|
| 1998 |
Müller M, Müller R, Yu TW, Floss HG. Synthesis of (-)-3-amino-3-deoxyquinic acid Journal of Organic Chemistry. 63: 9753-9755. DOI: 10.1021/Jo981291L |
0.488 |
|
| 1998 |
Yu TW, Shen Y, McDaniel R, Floss HG, Khosla C, Hopwood DA, Moore BS. Engineered biosynthesis of novel polyketides from Streptomyces spore pigment polyketide synthases Journal of the American Chemical Society. 120: 7749-7759. DOI: 10.1021/Ja9803658 |
0.666 |
|
| 1998 |
Gröcer D, Floss HG. Chapter 5 Biochemistry of Ergot Alkaloids-Achievements and Challenges Alkaloids: Chemistry and Biology. 50: 171-218. DOI: 10.1016/S1099-4831(08)60043-7 |
0.318 |
|
| 1997 |
Moore BS, Walker K, Tornus I, Handa S, Poralla K, Floss HG. Biosynthetic Studies of omega-Cycloheptyl Fatty Acids in Alicyclobacillus cycloheptanicus. Formation of Cycloheptanecarboxylic Acid from Phenylacetic Acid. The Journal of Organic Chemistry. 62: 2173-2185. PMID 11671526 |
0.66 |
|
| 1997 |
Handa S, Floss HG. Biosynthesis of ω-cyclohexyl fatty acids in Alicyclobacillus acidocaldarius: The stereochemistry of the initial 1,4-conjugate elimination Chemical Communications. 153-154. DOI: 10.1039/A607122H |
0.35 |
|
| 1997 |
Hu Y, Melville CR, Gould SJ, Floss HG. 3-Amino-4-hydroxybenzoic acid: The precursor of the C7N unit in asukamycin and manumycin Journal of the American Chemical Society. 119: 4301-4302. DOI: 10.1021/Ja9701016 |
0.736 |
|
| 1997 |
Valentine AM, Wilkinson B, Liu KE, Komar-Panicucci S, Priestley ND, Williams PG, Morimoto H, Floss HG, Lippard SJ. Tritiated chiral alkanes as substrates for soluble methane monooxygenase from Methylococcus capsulatus (Bath): Probes for the mechanism of hydroxylation Journal of the American Chemical Society. 119: 1818-1827. DOI: 10.1021/Ja963971G |
0.67 |
|
| 1996 |
Priestley ND, Smith TM, Shipley PR, Floss HG. Studies on the biosynthesis of thiostrepton: 4-(1-hydroxyethyl)quinoline-2-carboxylate as a free intermediate on the pathway to the quinaldic acid moiety. Bioorganic & Medicinal Chemistry. 4: 1135-47. PMID 8831986 DOI: 10.1016/0968-0896(96)00126-5 |
0.715 |
|
| 1996 |
Lin X, Hezari M, Koepp AE, Floss HG, Croteau R. Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in Pacific yew. Biochemistry. 35: 2968-77. PMID 8608134 DOI: 10.1021/Bi9526239 |
0.389 |
|
| 1996 |
Kim CG, Kirschning A, Bergon P, Zhou P, Su E, Sauerbrei B, Ning S, Ahn Y, Breuer M, Leistner E, Floss HG. Biosynthesis of 3-amino-5-hydroxybenzoic acid, the precursor of mC7N units in ansamycin antibiotics Journal of the American Chemical Society. 118: 7486-4791. DOI: 10.1021/Ja9601292 |
0.72 |
|
| 1996 |
Wilkinson B, Zhu M, Priestley ND, Nguyen HHT, Morimoto H, Williams PG, Chan SI, Floss HG. A concerted mechanism for ethane hydroxylation by the particulate methane monooxygenase from Methylococcus capsulatus (bath) Journal of the American Chemical Society. 118: 921-922. DOI: 10.1021/Ja953407Q |
0.691 |
|
| 1996 |
Chesters NCJE, Walker K, O'Hagan D, Floss HG. The biosynthesis of tropic acid: A reevaluation of the stereochemical course of the conversion of phenyllactate to tropate in Datura stramonium Journal of the American Chemical Society. 118: 925-926. DOI: 10.1021/Ja9531485 |
0.353 |
|
| 1995 |
Moore BS, Floss HG, Poralla K. Three new omega-cycloheptyl fatty acids from Alicyclobacillus cycloheptanicus and their biosynthetic interrelationships. Journal of Natural Products. 58: 590-3. PMID 7623036 DOI: 10.1021/Np50118A019 |
0.645 |
|
| 1995 |
Bechthold A, Sohng JK, Smith TM, Chu X, Floss HG. Identification of Streptomyces violaceoruber Tü22 genes involved in the biosynthesis of granaticin. Molecular & General Genetics : Mgg. 248: 610-20. PMID 7476861 DOI: 10.1007/Bf02423457 |
0.321 |
|
| 1995 |
Chesters NCJE, O'Hagan D, Robins RJ, Kastelle A, Floss HG. The biosynthesis of tropic acid: The stereochemical course of the mutase involved in hyoscyamine biosynthesis in Datura stramonium Journal of the Chemical Society - Series Chemical Communications. 129-130. DOI: 10.1039/C39950000129 |
0.385 |
|
| 1995 |
Bjorklund JA, Frenzel T, Rueffer M, Kobayashi M, Mocek U, Fox C, Beale JM, Gröger S, Zenk MH, Floss HG. Cryptic stereochemistry of berberine alkaloid biosynthesis Journal of the American Chemical Society. 117: 1533-1545. DOI: 10.1021/Ja00110A009 |
0.35 |
|
| 1995 |
Micklefield J, Harris KJ, Gröger S, Mocek U, Hilbi H, Dimroth P, Floss HG. Stereochemical course of malonate decarboxylation in Malonomonas rubra Journal of the American Chemical Society. 117: 1153-1154. DOI: 10.1021/Ja00108A042 |
0.561 |
|
| 1994 |
Moore BS, Floss HG. Biosynthetic studies on the origin of the cyclohexanecarboxylic acid moiety of ansatrienin A and omega-cyclohexyl fatty acids. Journal of Natural Products. 57: 382-6. PMID 8201312 DOI: 10.1021/Np50105A008 |
0.658 |
|
| 1994 |
Kirschning A, Bergon P, Wang JJ, Breazeale S, Floss HG. Synthesis of 4-amino 3,4-dideoxy-D-arabino-heptulosonic acid 7-phosphate, the biosynthetic precursor of C7N units in ansamycin antibiotics. Carbohydrate Research. 256: 245-56. PMID 8187101 DOI: 10.1016/0008-6215(94)84211-6 |
0.557 |
|
| 1994 |
Fleming PE, Floss HG, Haertel M, Knaggs AR, Lansing A, Mocek U, Walker KD. Biosynthetic studies on taxol Pure and Applied Chemistry. 66: 2045-2048. DOI: 10.1351/Pac199466102045 |
0.353 |
|
| 1994 |
Lee JP, Tsao SW, Chang C, He XG, Floss HG. Biosynthesis of naphthomycin A in Streptomyces collinus Canadian Journal of Chemistry. 72: 182-187. DOI: 10.1139/V94-028 |
0.394 |
|
| 1994 |
Axelsson BS, Floss HG, Lee S, Saeed A, Spencer PA, Young DW. Stereochemistry of conversion of the suicide substrates β-chloro-D-alanine and D- and L-serine O-sulfates into pyruvate by D-amino acid aminotransferase and by L-aspartate aminotransferase Journal of the Chemical Society, Perkin Transactions 1. 2137-2142. DOI: 10.1039/P19940002137 |
0.338 |
|
| 1994 |
Hanefeld U, Floss HG, Laatsch H. Biosynthesis of the marine antibiotic pentabromopseudilin. 1. The benzene ring Journal of Organic Chemistry. 59: 3604-3608. DOI: 10.1021/Jo00092A020 |
0.39 |
|
| 1994 |
Bockholt H, Udvarnoki G, Rohr J, Mocek U, Beale JM, Floss HG. Biosynthetic studies on the xanthone antibiotics lysolipins X and I Journal of Organic Chemistry. 59: 2064-2069. DOI: 10.1021/Jo00087A021 |
0.3 |
|
| 1993 |
Smith TM, Priestley ND, Knaggs AR, Nguyen T, Floss HG. 3,4-Dimethylindole-2-carboxylate and 4-(1-hydroxyethyl)quinoline-2-carboxylate activating enzymes from the nosiheptide and thiostrepton producers, Streptomyces actuosus and Streptomyces laurentii Journal of the Chemical Society - Series Chemical Communications. 1612-1614. DOI: 10.1039/C39930001612 |
0.679 |
|
| 1993 |
Cho H, Sattler I, Beale JM, Zeeck A, Floss HG. Some aspects of the stereochemistry and biosynthesis of asukamycin Journal of Organic Chemistry. 58: 7925-7928. DOI: 10.1021/Jo00079A047 |
0.305 |
|
| 1993 |
Van 'T Land CW, Mocek U, Floss HG. Biosynthesis of the phenazine antibiotics, the saphenamycins and esmeraldins, in Streptomyces antibioticus Journal of Organic Chemistry. 58: 6576-6582. DOI: 10.1021/Jo00076A014 |
0.396 |
|
| 1993 |
Cho H, Beale JM, Graff C, Mocek U, Nakagawa A, Omura S, Floss HG. Studies on the biosynthesis of the antibiotic reductiomycin in Streptomyces xanthochromogenus Journal of the American Chemical Society. 115: 12296-12304. DOI: 10.1021/Ja00079A009 |
0.414 |
|
| 1993 |
Moore BS, Cho H, Casati R, Kennedy E, Reynolds KA, Mocek U, Beale JM, Floss HG. Biosynthetic studies on ansatrienin A. Formation of the cyclohexanecarboxylic acid moiety. [Erratum to document cited in CA119(9):90959x] Journal of the American Chemical Society. 115: 11656-11656. DOI: 10.1021/Ja00077A100 |
0.615 |
|
| 1993 |
Mocek U, Zeng Z, O'Hagan D, Zhou P, Fan LDG, Beale JM, Floss HG. Biosynthesis of the modified peptide antibiotic thiostrepton in Streptomyces azureus and Streptomyces laurentii Journal of the American Chemical Society. 115: 7992-8001. DOI: 10.1021/Ja00071A009 |
0.368 |
|
| 1993 |
Mocek U, Knaggs AR, Tsuchiya R, Nguyen T, Beale JM, Floss HG. Biosynthesis of the modified peptide antibiotic nosiheptide in Streptomyces actuosus Journal of the American Chemical Society. 115: 7557-7568. DOI: 10.1021/Ja00070A001 |
0.365 |
|
| 1993 |
Moore BS, Poralla K, Floss HG. Biosynthesis of the cyclohexanecarboxylic acid starter unit of .omega.-cyclohexyl fatty acids in Alicyclobacillus acidocaldarius Journal of the American Chemical Society. 115: 5267-5274. DOI: 10.1021/Ja00065A043 |
0.664 |
|
| 1993 |
Moore BS, Cho H, Casati R, Kennedy E, Reynolds KA, Mocek U, Beale JM, Floss HG. Biosynthetic studies on ansatrienin A. Formation of the cyclohexanecarboxylic acid moiety Journal of the American Chemical Society. 115: 5254-5266. DOI: 10.1021/Ja00065A042 |
0.651 |
|
| 1993 |
Moore BS, Cho H, Casati R, Kennedy E, Reynolds KA, Mocek U, Beale JM, Floss HG. Biosynthetic studies on ansatrienin A. Formation of the cyclohexanecarboxylic acid moiety Journal of the American Chemical Society. 115: 5254-5266. DOI: 10.1021/ja00065a042 |
0.632 |
|
| 1993 |
Kozikowski AP, Chen C, Wu JP, Shibuya M, Kim CG, Floss HG. Probing ergot alkaloid biosynthesis: Intermediates in the formation of ring C Journal of the American Chemical Society. 115: 2482-2488. DOI: 10.1021/Ja00059A051 |
0.326 |
|
| 1993 |
Froland WA, Priestley ND, Floss HG, Williams PG, Morimoto H, Lipscomb JD. Evidence supporting the formation of a substrate radical during H2O2-coupled MMO catalyzed oxidation of chiral ethane Journal of Inorganic Biochemistry. 51: 245. DOI: 10.1016/0162-0134(93)85279-H |
0.657 |
|
| 1992 |
Reynolds KA, Wang P, Fox KM, Speedie MK, Lam Y, Floss HG. Purification and characterization of a novel enoyl coenzyme A reductase from Streptomyces collinus. Journal of Bacteriology. 174: 3850-4. PMID 1597409 DOI: 10.1128/Jb.174.12.3850-3854.1992 |
0.393 |
|
| 1992 |
Thompson MW, Strohl WR, Floss HG. Purification and characterization of TDP-D-glucose 4,6-dehydratase from anthracycline-producing streptomycetes. Journal of General Microbiology. 138: 779-86. PMID 1588310 DOI: 10.1099/00221287-138-4-779 |
0.301 |
|
| 1992 |
Reynolds KA, Wang P, Fox KM, Floss HG. Biosynthesis of ansatrienin by Streptomyces collinus: cell-free transformations of cyclohexene- and cyclohexadienecarboxylic acids. The Journal of Antibiotics. 45: 411-9. PMID 1577668 DOI: 10.7164/Antibiotics.45.411 |
0.341 |
|
| 1992 |
Zhou P, Mocek U, Siesel B, Floss HG. Biosynthesis of pyrrolnitrin. Incorporation of 13C, 15N double-labelled D- and L-tryptophan. Journal of Basic Microbiology. 32: 209-14. PMID 1512712 DOI: 10.1002/Jobm.3620320312 |
0.313 |
|
| 1992 |
Ahn Y, Ye Q, Cho H, Walsh CT, Floss HG. Stereochemistry of carbon-phosphorus cleavage in ethylphosphonate catalyzed by C-P lyase from Escherichia coli Journal of the American Chemical Society. 114: 7953-7954. DOI: 10.1021/Ja00046A075 |
0.312 |
|
| 1992 |
Priestley ND, Floss HG, Froland WA, Lipscomb JD, Williams PG, Morimoto H. Cryptic stereospecificity of methane monooxygenase Journal of the American Chemical Society. 114: 7561-7562. DOI: 10.1021/Ja00045A037 |
0.67 |
|
| 1992 |
Kim CG, Kirschning A, Bergon P, Ahn Y, Wang JJ, Shibuya M, Floss HG. Formation of 3-amino-5-hydroxybenzoic acid, the precursor of mC7N units in ansamycin antibiotics, by a new variant of the shikimate pathway Journal of the American Chemical Society. 114: 4941-4943. DOI: 10.1021/Ja00038A090 |
0.547 |
|
| 1992 |
Cho H, Heide L, Floss HG. Synthesis of D-(-)-[1,7-13C2]shikimic acid Journal of Labelled Compounds and Radiopharmaceuticals. 31: 589-594. DOI: 10.1002/Jlcr.2580310804 |
0.379 |
|
| 1991 |
Ho DK, Wu JC, Santi DV, Floss HG. Stereochemical studies of the C-methylation of deoxycytidine catalyzed by HhaI methylase and the N-methylation of deoxyadenosine catalyzed by EcoRI methylase. Archives of Biochemistry and Biophysics. 284: 264-9. PMID 1989510 DOI: 10.1016/0003-9861(91)90294-S |
0.327 |
|
| 1991 |
Reynolds K, Martin J, Shen SJ, Esaki N, Soda K, Floss HG. Mechanistic studies of two amino acid racemases of broad substrate specificity from Pseudomonas striata and Aeromonas caviae. Journal of Basic Microbiology. 31: 177-88. PMID 1920082 DOI: 10.1002/Jobm.3620310304 |
0.359 |
|
| 1991 |
Gröger D, Gröger L, D'Amico D, He MX, Floss HG. Steric course of the N-methylation in the biosynthesis of ergot alkaloids by Claviceps purpurea. Journal of Basic Microbiology. 31: 121-5. PMID 1880714 DOI: 10.1002/Jobm.3620310209 |
0.33 |
|
| 1991 |
Kealey JT, Lee S, Floss HG, Santi DV. Stereochemistry of methyl transfer catalyzed by tRNA (m5U54)-methyltransferase--evidence for a single displacement mechanism. Nucleic Acids Research. 19: 6465-8. PMID 1754383 DOI: 10.1093/Nar/19.23.6465 |
0.317 |
|
| 1990 |
Bartel PL, Zhu CB, Lampel JS, Dosch DC, Connors NC, Strohl WR, Beale JM, Floss HG. Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions. Journal of Bacteriology. 172: 4816-26. PMID 2394677 DOI: 10.1128/Jb.172.9.4816-4826.1990 |
0.341 |
|
| 1990 |
Frenzel T, Zhou P, Floss HG. Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosylmethionine:tryptophan 2-methyltransferase. Archives of Biochemistry and Biophysics. 278: 35-40. PMID 2321967 DOI: 10.1016/0003-9861(90)90227-P |
0.329 |
|
| 1990 |
Oths PJ, Mayer RM, Floss HG. Stereochemistry and mechanism of the GDP-mannose dehydratase reaction. Carbohydrate Research. 198: 91-100. PMID 1693883 DOI: 10.1016/0008-6215(90)84279-4 |
0.377 |
|
| 1990 |
Vanoni MA, Lee S, Floss HG, Matthews RG. Stereochemistry of reduction of methylenetetrahydrofolate to methyltetrahydrofolate catalyzed by pig liver methylenetetrahydrofolate reductase Journal of the American Chemical Society. 112: 3987-3992. DOI: 10.1021/Ja00166A040 |
0.364 |
|
| 1990 |
Thiericke R, Zeeck A, Nakagawa A, Omura S, Herrold RE, Wu STS, Beale JM, Floss HG. Biosynthesis of the manumycin group antibiotics Journal of the American Chemical Society. 112: 3979-3987. DOI: 10.1021/Ja00166A039 |
0.37 |
|
| 1990 |
Shibuya M, Chou HM, Fountoulakis M, Hassam S, Kim SU, Kobayashi K, Otsuka H, Rogalska E, Cassady JM, Floss HG. Stereochemistry of the isoprenylation of tryptophan catalyzed by 4-(.gamma.,.gamma.-dimethylallyl)tryptophan synthase from Claviceps, the first pathway-specific enzyme in ergot alkaloid biosynthesis Journal of the American Chemical Society. 112: 297-304. DOI: 10.1021/Ja00157A046 |
0.302 |
|
| 1989 |
Rohr J, Beale JM, Floss HG. Urdamycins, new angucycline antibiotics from Streptomyces fradiae. IV. Biosynthetic studies of urdamycins A-D. The Journal of Antibiotics. 42: 1151-7. PMID 2753820 DOI: 10.7164/Antibiotics.42.1151 |
0.353 |
|
| 1989 |
Thiericke R, Zeeck A, Robinson JA, Beale JM, Floss HG. The biosynthesis of manumycin; origin of the oxygen and nitrogen atoms Journal of the Chemical Society, Chemical Communications. 402-403. DOI: 10.1039/C39890000402 |
0.478 |
|
| 1989 |
Zhou P, O'Hagan D, Mocek U, Zeng Z, Yuen LD, Frenzel T, Unkefer CJ, Beale JM, Floss HG. Biosynthesis of the antibiotic thiostrepton. Methylation of tryptophan in the formation of the quinaldic acid moiety by transfer of the methionine methyl group with net retention of configuration Journal of the American Chemical Society. 111: 7274-7276. DOI: 10.1021/Ja00200A065 |
0.346 |
|
| 1989 |
Woo ER, Fujii I, Ebizuka Y, Sankawa U, Kawaguchi A, Huang S, Beale JM, Shibuya M, Mocek U, Floss HG. Nonstereospecific proton removal in the enzymatic formation of orsellinic acid from chiral malonate Journal of the American Chemical Society. 111: 5498-5500. DOI: 10.1021/Ja00196A084 |
0.347 |
|
| 1989 |
Heide L, Floss HG, Tabata M. Incorporation of shikimic acid into p-hydroxybenzoic acid in Lithospermum erythrorhizon cell cultures Phytochemistry. 28: 2643-2645. DOI: 10.1016/S0031-9422(00)98058-0 |
0.353 |
|
| 1988 |
Keller PJ, Le Van Q, Kim SU, Bown DH, Chen HC, Kohnle A, Bacher A, Floss HG. Biosynthesis of riboflavin: mechanism of formation of the ribitylamino linkage. Biochemistry. 27: 1117-20. PMID 3130093 DOI: 10.1021/Bi00404A006 |
0.338 |
|
| 1988 |
Kozikowski AP, Okita M, Kobayashi M, Floss HG. Probing ergot alkaloid biosynthesis: Synthesis and feeding of a proposed intermediate along the biosynthetic pathway. A new amidomalonate for tryptophan elaboration Journal of Organic Chemistry. 53: 863-869. DOI: 10.1021/Jo00239A034 |
0.309 |
|
| 1988 |
Frenzel T, Beale JM, Kobayashi M, Zenk MH, Floss HG. Stereochemistry of enzymatic formation of the berberine bridge in protoberberine alkaloids Journal of the American Chemical Society. 110: 7878-7880. DOI: 10.1021/Ja00231A050 |
0.305 |
|
| 1988 |
Beale JM, Herrold RE, Floss HG, Thiericke R, Zeeck A, Nakagawa A, Omura S. Studies on the biosynthesis of the meta-C7N unit in the antibiotics manumycin and asukamycin Journal of the American Chemical Society. 110: 4435-4437. DOI: 10.1021/Ja00221A066 |
0.366 |
|
| 1987 |
Wu TS, Duncan J, Tsao SW, Chang CJ, Keller PJ, Floss HG. Biosynthesis of the ansamycin antibiotic ansatrienin (mycotrienin) by Streptomyces collinus. Journal of Natural Products. 50: 108-18. PMID 3598593 DOI: 10.1021/Np50049A015 |
0.397 |
|
| 1987 |
Degwert U, van Hülst R, Pape H, Herrold RE, Beale JM, Keller PJ, Lee JP, Floss HG. Studies on the biosynthesis of the alpha-glucosidase inhibitor acarbose: valienamine, a m-C7N unit not derived from the shikimate pathway. The Journal of Antibiotics. 40: 855-61. PMID 3301773 DOI: 10.7164/Antibiotics.40.855 |
0.376 |
|
| 1987 |
Otsuka H, Floss HG. Steric course of the rhodium-catalyzed decarbonylation of chiral 4-methyl-[1-3H,2-2H1]pentanal. Zeitschrift FüR Naturforschung. C, Journal of Biosciences. 42: 449-54. PMID 2955591 DOI: 10.1515/Znc-1987-0421 |
0.345 |
|
| 1987 |
Palcic MM, Shen SJ, Schleicher E, Kumagai H, Sawada S, Yamada H, Floss HG. Stereochemistry and mechanism of reactions catalyzed by tyrosine phenol-lyase from Escherichia intermedia. Zeitschrift FüR Naturforschung. C, Journal of Biosciences. 42: 307-18. PMID 2955585 DOI: 10.1515/Znc-1987-0401 |
0.322 |
|
| 1987 |
Casati R, Beale JM, Floss HG. Biosynthesis of ansatrienin. Nonincorporation of shikimic acid into the mC7N unit and stereochemistry of its conversion to the cyclohexanecarboxylic acid moiety Journal of the American Chemical Society. 109: 8102-8104. DOI: 10.1021/Ja00260A035 |
0.354 |
|
| 1987 |
Zydowsky LD, Zydowsky TM, Haas ES, Brown JW, Reeve JN, Floss HG. Stereochemical course of methyl transfer from methanol to methyl coenzyme M in cell-free extracts of Methanosarcina barkeri Journal of the American Chemical Society. 109: 7922-7923. DOI: 10.1021/Ja00259A073 |
0.315 |
|
| 1987 |
Raybuck SA, Bastian NR, Zydowsky LD, Kobayashi K, Floss HG, Orme-Johnson WH, Walsh CT. Nickel-containing carbon monoxide dehydrogenase catalyzes reversible decarbonylation of acetyl CoA with retention of stereochemistry at the methyl group Journal of the American Chemical Society. 109: 3171-3173. DOI: 10.1021/Ja00244A065 |
0.315 |
|
| 1986 |
Floss HG, Keller PJ, Beale JM. Studies on the biosynthesis of antibiotics. Journal of Natural Products. 49: 957-70. PMID 3553432 DOI: 10.1351/Pac198961030485 |
0.304 |
|
| 1986 |
Lee JJ, Lee JP, Keller PJ, Cottrell CE, Chang C, Zähner H, Floss HG. Further studies on the biosynthesis of chlorothricin. The Journal of Antibiotics. 39: 1123-34. PMID 3531133 DOI: 10.7164/Antibiotics.39.1123 |
0.37 |
|
| 1986 |
He XG, Chang CC, Chang CJ, Vederas JC, McInnes AG, Walter JA, Floss HG. Further studies on the biosynthesis of granaticin. Zeitschrift FüR Naturforschung. C, Journal of Biosciences. 41: 215-21. PMID 2939642 DOI: 10.1515/znc-1986-1-232 |
0.459 |
|
| 1986 |
Huang S, Beale JM, Keller PJ, Floss HG. Synthesis of (R)- and (S)-[1-13C1,2-2H1]malonate and its stereochemical analysis by NMR spectroscopy Journal of the American Chemical Society. 108: 1100-1101. DOI: 10.1021/Ja00265A051 |
0.315 |
|
| 1986 |
Keller PJ, Floss HG, Le Van Q, Schwarzkopf B, Bacher A. Biosynthesis of methanopterin in Methanobacterium thermoautotrophicum Journal of the American Chemical Society. 108: 344-345. DOI: 10.1021/Ja00262A053 |
0.337 |
|
| 1985 |
Le Van Q, Keller PJ, Bown DH, Floss HG, Bacher A. Biosynthesis of riboflavin in Bacillus subtilis: origin of the four-carbon moiety. Journal of Bacteriology. 162: 1280-4. PMID 3922947 DOI: 10.1128/Jb.162.3.1280-1284.1985 |
0.328 |
|
| 1985 |
Hopwood DA, Malpartida F, Kieser HM, Ikeda H, Duncan J, Fujii I, Rudd BA, Floss HG, Omura S. Production of 'hybrid' antibiotics by genetic engineering. Nature. 314: 642-4. PMID 3857464 DOI: 10.1038/314642A0 |
0.303 |
|
| 1985 |
Nakagawa A, Wu TS, Keller PJ, Lee JP, Omura S, Floss HG. Biosynthesis of asukamycin. Formation of the 2-amino-3-hydroxycyclopent-2-enone moiety Journal of the Chemical Society - Series Chemical Communications. 519-521. DOI: 10.1039/C39850000519 |
0.385 |
|
| 1985 |
Bacher A, Le Van Q, Keller PJ, Floss HG. Biosynthesis of riboflavin. Incorporation of multiply 13C-labeled precursors into the xylene ring Journal of the American Chemical Society. 107: 6380-6385. DOI: 10.1002/Chin.198607323 |
0.324 |
|
| 1984 |
Asano Y, Woodard RW, Houck DR, Floss HG. Stereochemical course of the transmethylation catalyzed by histamine N-methyltransferase. Archives of Biochemistry and Biophysics. 231: 253-6. PMID 6721499 DOI: 10.1016/0003-9861(84)90385-0 |
0.594 |
|
| 1984 |
Nielsen P, Neuberger G, Floss HG, Bacher A. Biosynthesis of riboflavin. Enzymatic formation of the xylene moiety from [14C]ribulose 5-phosphate. Biochemical and Biophysical Research Communications. 118: 814-20. PMID 6546684 DOI: 10.1016/0006-291X(84)91467-0 |
0.371 |
|
| 1984 |
Takeda Y, Mak V, Chang CC, Chang CJ, Floss HG. Biosynthesis of ketomycin. The Journal of Antibiotics. 37: 868-75. PMID 6384167 DOI: 10.7164/Antibiotics.37.868 |
0.399 |
|
| 1984 |
Badet B, Lee K, Floss HG, Walsh CT. Stereochemical studies of processing of D-and L-isomers of suicide substrates by an amino acid racemase from Pseudomonas striata Journal of the Chemical Society, Chemical Communications. 838-840. DOI: 10.1039/C39840000838 |
0.337 |
|
| 1984 |
Kobayashi K, Kakinuma K, Floss HG. Synthesis of chiral acetic acid by chirality transfer from D-glucose Journal of Organic Chemistry. 49: 1290-1291. DOI: 10.1002/Chin.198434141 |
0.316 |
|
| 1983 |
Bacher A, Le Van Q, Keller PJ, Floss HG. Biosynthesis of riboflavin. Incorporation of 13C-labeled precursors into the xylene ring. The Journal of Biological Chemistry. 258: 13431-7. PMID 6417129 DOI: 10.1021/Ja00308A037 |
0.321 |
|
| 1983 |
Shen S, Floss HG, Kumagai H, Yamada H, Soda NEK, Wasserman SA, Walsh C. Mechanism of pyridoxal phosphate-dependent enzymatic amino-acid racemization Journal of the Chemical Society, Chemical Communications. 82-83. DOI: 10.1039/C39830000082 |
0.36 |
|
| 1983 |
Kobayashi K, Jadhav PK, Zydowsky TM, Floss HG. A simple and efficient synthesis of chiral acetic acid of high optical purity The Journal of Organic Chemistry. 48: 3510-3512. DOI: 10.1021/Jo00168A027 |
0.313 |
|
| 1983 |
Floss HG, Van QL, Keller PJ, Bacher A. Biosynthesis of riboflavin. An unusual rearrangement in the formation of 6,7-dimethyl-8-ribityllumazine Journal of the American Chemical Society. 105: 2493-2494. DOI: 10.1021/Ja00346A075 |
0.328 |
|
| 1983 |
Keller PJ, Le Van Q, Bacher A, Floss HG. Biosynthesis of riboflavin Tetrahedron. 39: 3471-3481. DOI: 10.1016/S0040-4020(01)88657-9 |
0.334 |
|
| 1982 |
Vederas J, Floss H. Additions and Corrections - Stereochemistry of Pyridoxal Phosphate Catalyzed Enzyme Reactions Accounts of Chemical Research. 15: 94-94. DOI: 10.1021/Ar00075A601 |
0.502 |
|
| 1982 |
Floss HG, Vederas JC. Chapter 4 Stereochemistry of pyridoxal phosphate-catalyzed reactions New Comprehensive Biochemistry. 3: 161-199. DOI: 10.1016/S0167-7306(08)60395-6 |
0.547 |
|
| 1982 |
Floss HG. [10] Preparation, analysis, and biochemical applications of chiral methyl groups Methods in Enzymology. 87: 126-159. DOI: 10.1016/S0076-6879(82)87012-2 |
0.355 |
|
| 1982 |
Bacher A, Levan Q, Buehler M+, Keller PJ, Eimicke V, Floss HG. Biosynthesis Of Riboflavin. Incorporation Of D‐(1‐13C)Ribose Cheminform. 13. DOI: 10.1002/Chin.198242351 |
0.336 |
|
| 1981 |
Chang CJ, Floss HG, Hook DJ, Mabe JA, Manni PE, Martin LL, Schröder K, Shieh TL. The biosynthesis of the antibiotic pyrrolnitrin by Pseudomonas aureofaciens. The Journal of Antibiotics. 34: 555-66. PMID 7275838 DOI: 10.7164/Antibiotics.34.555 |
0.383 |
|
| 1981 |
Woodard RW, Weaver J, Floss HG. Stereochemical course of the methylation of the polygalacturonic acid carboxyl groups of pectin. Archives of Biochemistry and Biophysics. 207: 51-4. PMID 7235721 DOI: 10.1016/0003-9861(81)90006-0 |
0.611 |
|
| 1981 |
Mascaretti OA, Chang CJ, Hook D, Otsuka H, Kreutzer EF, Floss HG. Biosynthesis of the macrolide antibiotic chlorothricin. Biochemistry. 20: 919-24. PMID 7011379 DOI: 10.1021/Bi00507A042 |
0.373 |
|
| 1981 |
Houck DR, Floss HG. Preparation of Stereospecifically α- and β-Tritiated Tryptamine and the Stereo-Chemistry of Aromatic L-Amino Acid Decarboxylase Journal of Natural Products. 44: 759-762. DOI: 10.1021/Np50018A031 |
0.303 |
|
| 1981 |
Quigley F, Floss H. Correction. Mechanism of Amino Acid α-Hydroxylation and Formation of the Lysergyl Moiety in Ergotamine Biosynthesis The Journal of Organic Chemistry. 46: 5459-5459. DOI: 10.1021/Jo00339A607 |
0.343 |
|
| 1981 |
Chen TSS, Chang C, Floss HG. Biosynthesis of boromycin The Journal of Organic Chemistry. 46: 2661-2665. DOI: 10.1021/Jo00326A010 |
0.336 |
|
| 1981 |
Quigley FR, Floss HG. Mechanism of amino acid .alpha.-hydroxylation and formation of the lysergyl moiety in ergotamine biosynthesis The Journal of Organic Chemistry. 46: 464-466. DOI: 10.1021/Jo00315A051 |
0.333 |
|
| 1980 |
Woodard RW, Tsai MD, Floss HG, Crooks PA, Coward JK. Stereochemical course of the transmethylation catalyzed by catechol O-methyltransferase. The Journal of Biological Chemistry. 255: 9124-7. PMID 6997310 |
0.645 |
|
| 1980 |
Robbers JE, Otsuka H, Floss HG, Arnold EV, Clardy J. Clavicipitic acid: its structure, biosynthesis, and role in ergot alkaloid formation The Journal of Organic Chemistry. 45: 1117-1121. DOI: 10.1021/Jo01294A039 |
0.339 |
|
| 1980 |
Woodard RW, Mascaro L, Hörhammer R, Eisenstein S, Floss HG. Stereochemistry of indolmycin biosynthesis. Steric course of C- and N-methylation reactions Journal of the American Chemical Society. 102: 6314-6318. DOI: 10.1021/Ja00540A024 |
0.602 |
|
| 1980 |
Vederas JC, Floss HG. Stereochemistry of pyridoxal phosphate catalyzed enzyme reactions Accounts of Chemical Research. 13: 455-463. DOI: 10.1002/Chin.198116352 |
0.501 |
|
| 1980 |
Otsuka H, Mascaretti OA, Hurley LH, Floss HG. Stereochemical aspects of the biosynthesis of spectinomycin Journal of the American Chemical Society. 102: 6817-6820. DOI: 10.1002/Chin.198104343 |
0.539 |
|
| 1979 |
Tsai MD, Floss HG, Rosenfeld HJ, Roberts J. Stereochemistry and mechanism of reactions catalyzed by indolyl-3-alkane alpha-hydroxylase. The Journal of Biological Chemistry. 254: 6437-43. PMID 447726 |
0.477 |
|
| 1979 |
Floss HG, Tsai MD. Chiral methyl groups. Advances in Enzymology and Related Areas of Molecular Biology. 50: 243-302. PMID 386720 DOI: 10.1002/9780470122952.Ch5 |
0.46 |
|
| 1979 |
Otsuka H, Anderson JA, Floss HG. The stage of N-methylation in ergot alkaloid biosynthesis Journal of the Chemical Society, Chemical Communications. 660-662. DOI: 10.1039/C39790000660 |
0.321 |
|
| 1978 |
Tsai MD, Weaver J, Floss HG, Conn EE, Creveling RK, Mazelis M. Stereochemistry of the beta-cyanoalanine synthetase and S-alkylcysteine lyase reactions. Archives of Biochemistry and Biophysics. 190: 553-9. PMID 718168 DOI: 10.1016/0003-9861(78)90310-7 |
0.67 |
|
| 1978 |
Shimada K, Hook DJ, Warner GF, Floss HG. Biosynthesis of the antibiotic 2,5-dihydrophenylalanine by Streptomyces arenae. Biochemistry. 17: 3054-8. PMID 698184 DOI: 10.1021/Bi00608A017 |
0.377 |
|
| 1978 |
Tsai MD, Weintraub HJ, Byrn SR, Chang C, Floss HG. Conformation-reactivity relationship for pyridoxal Schiff's bases. Rates of racemization and alpha-hydrogen exchange of the pyridoxal Schiff's bases of amino acids. Biochemistry. 17: 3183-8. PMID 687574 DOI: 10.1021/Bi00609A002 |
0.49 |
|
| 1978 |
Tsai MD, Byrn SR, Chang C, Floss HG, Weintraub HJ. Conformational analysis of pyridoxal Schiff's bases. Nuclear magnetic resonance studies of the conformations about the C4-C4', Calpha-Cbeta, and N-Calpha bonds of the pyridoxal Schiff's bases of amino acids. Biochemistry. 17: 3177-82. PMID 687573 DOI: 10.1021/Bi00609A001 |
0.529 |
|
| 1978 |
Holzbach R, Pape H, Hook D, Kreutzer EF, Chang C, Floss HG. Biosynthesis of the macrolide antibiotic chlorothricin: basic building blocks. Biochemistry. 17: 556-60. PMID 620008 DOI: 10.1021/Bi00596A029 |
0.404 |
|
| 1978 |
Vederas JC, Schleicher E, Tsai MD, Floss HG. Stereochemistry and mechanism of reactions catalyzed by tryptophanase Escherichia coli. The Journal of Biological Chemistry. 253: 5350-4. PMID 353050 |
0.603 |
|
| 1978 |
Tsai MD, Schleicher E, Potts R, Skye GE, Floss HG. Stereochemistry and mechanism of reactions catalyzed by tryptophan synthetase and its beta2 subunit. The Journal of Biological Chemistry. 253: 5344-9. PMID 149794 |
0.374 |
|
| 1977 |
Crider AM, Robinson JM, Floss HG, Cassady JM, Clemens JA. Ergot alkaloids. Synthesis of 6-alkyl-8-ergolenes and 6-methyl-8-aminoergolines as potential prolactin inhibitors. Journal of Medicinal Chemistry. 20: 1473-7. PMID 915908 DOI: 10.1002/Chin.197816332 |
0.328 |
|
| 1977 |
Tatum CM, Benkovic PA, Benkovic SJ, Potts R, Schleicher E, Floss HG. Stereochemistry of methylene transfer involving 5,10-methylenetetrahydrofolate. Biochemistry. 16: 1093-102. PMID 849409 DOI: 10.1021/Bi00625A010 |
0.317 |
|
| 1977 |
Chang C, Shieh TL, Floss HG. Model studies of pyridoxal Schiff's bases. Coplanarity and intramolecular hydrogen bonding. Journal of Medicinal Chemistry. 20: 176-8. PMID 833823 DOI: 10.1002/Chin.197722358 |
0.302 |
|
| 1977 |
Mascaro L, Horhammer R, Eisenstein S, Seller LK, Mascaro K, Floss HG. Synthesis of methionine carrying a chiral methyl group and its use in determining the steric course of the enzymatic C-methylation of indolepyruvate during indolmycin biosynthesis. Journal of the American Chemical Society. 99: 273-4. PMID 830683 DOI: 10.1002/Chin.197714356 |
0.339 |
|
| 1977 |
Gustafson ME, Miller D, Davis PJ, Rosazza JP, Chang Cj, Floss HG. Stereochemistry of the side-chain dehydrogenation of N-benzyloxycarbonyl-(S)-tryptophan by Chromobacterium violaceum Journal of the Chemical Society, Chemical Communications. 842-843. DOI: 10.1039/C39770000842 |
0.308 |
|
| 1977 |
Tatum C, Vederas J, Schleicher E, Benkovic SJ, Floss H. Stereospecificity of thymidylate synthetase Journal of the Chemical Society, Chemical Communications. 218-220. DOI: 10.1039/C39770000218 |
0.511 |
|
| 1977 |
Kumagai H, Yamada H, Sawada S, Schleicher E, Mascaro K, Floss HG. Stereochemistry of the conversion of serine and tyrosine into pyruvate by tyrosine phenol-lyase Journal of the Chemical Society, Chemical Communications. 85-86. DOI: 10.1039/C39770000085 |
0.35 |
|
| 1976 |
Lee SL, Floss HG, Heinstein P. Purification and properties of dimethylallylpyrophosphate:tryptopharm dimethylallyl transferase, the first enzyme of ergot alkaloid biosynthesis in Claviceps. sp. SD 58. Archives of Biochemistry and Biophysics. 177: 84-94. PMID 999297 DOI: 10.1016/0003-9861(76)90418-5 |
0.305 |
|
| 1976 |
Chang CJ, Floss HG, Hurley LH, Zmijewski M. Application of long-range spin-spin couplings in biosynthetic studies. The Journal of Organic Chemistry. 41: 2932-4. PMID 956946 DOI: 10.1021/Jo00879A033 |
0.443 |
|
| 1975 |
Li GS, Robinson JM, Floss HG, Cassady JM. Ergot alkaloids. Synthesis of 6-methyl-8-ergolenes as inhibitors of prolactin release. Journal of Medicinal Chemistry. 18: 892-5. PMID 1159711 DOI: 10.1002/Chin.197601359 |
0.33 |
|
| 1975 |
Larsen PO, Onderka DK, Floss HG. Biosynthesis of phenylalanine, tyrosine, 3-(3-carbocyphenyl) alanine and 3-(3-carbocy-4-hydroxyphenyl) alanine in higher plants. Examples of the transformation possibilities for chorismic acid. Biochimica Et Biophysica Acta. 381: 397-408. PMID 1120151 DOI: 10.1016/0304-4165(75)90245-7 |
0.412 |
|
| 1975 |
Speedie MK, Hornemann U, Floss HG. S-adenoxylmethionine:indolepyruvate 3-methyltransferase. Methods in Enzymology. 43: 498-502. PMID 805896 DOI: 10.1016/0076-6879(75)43110-X |
0.338 |
|
| 1973 |
Robbers JE, Robertson LW, Hornemann KM, Jindra A, Floss HG. Physiological studies on ergot: further studies on the induction of alkaloid synthesis by tryptophan and its inhibition by phosphate. Journal of Bacteriology. 112: 791-6. PMID 5086659 DOI: 10.1128/Jb.112.2.791-796.1972 |
0.317 |
|
| 1973 |
Lin CCL, Blair GE, Cassady JM, Groeger D, Maier W, Floss HG. Biosynthesis Of Ergot Alkaloids, Synthesis Of 6-Methyl-8-Acetoxymethylene-9-Ergolene And Its Incorporation Into Ergotoxine By Claviceps Cheminform. 4. DOI: 10.1002/Chin.197339417 |
0.312 |
|
| 1973 |
MARTIN LL, CHANG C, FLOSS HG, MABE JA, HAGAMAN EW, WENKERT E. ChemInform Abstract: (13)C-NMR-UNTERSUCHUNG DER BIOSYNTH. VON PYRROLNITRIN AUS (3′-(13)C)TRYPTOPHAN-ALANIN MIT PSEUDOMONAS Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197308067 |
0.308 |
|
| 1972 |
Floss HG, Manni PE, Hamill RL, Mabe JA. Further studies on the biosynthesis of pyrrolnitrin from tryptophan by Pseudomonas. Biochemical and Biophysical Research Communications. 45: 781-7. PMID 5128184 DOI: 10.1016/0006-291X(71)90485-2 |
0.37 |
|
| 1972 |
Larsen PO, Onderka DK, Floss HG. Steric course and rearrangements in the biosynthesis of phenylalanine, tyrosine, and 3-(3-carboxyphenyl)ala nine from shikimic acid in higher plants Journal of the Chemical Society, Chemical Communications. 842-843. DOI: 10.1039/C39720000842 |
0.375 |
|
| 1971 |
Hornemann U, Hurley LH, Speedie MK, Floss HG. The biosynthesis of indolmycin Journal of the American Chemical Society. 93: 3028-3035. PMID 5095271 DOI: 10.1021/Ja00741A035 |
0.557 |
|
| 1971 |
Scharf KH, Zenk MH, Onderka DK, Carroll M, Floss HG. Stereochemistry of the enzymatic and non-enzymatic conversion of 3-dehydroshikimate into protocatechuate Journal of the Chemical Society D: Chemical Communications. 765-766. DOI: 10.1039/C29710000765 |
0.355 |
|
| 1971 |
Scharf K-, Zenk MH, Onderka DK, Carroll M, Floss HG. Stereochemistry of hydrogen elimination from C-6 of shikimate in naphthoquinone biosynthesis Journal of the Chemical Society D: Chemical Communications. 576-577. DOI: 10.1039/C29710000576 |
0.343 |
|
| 1970 |
Hornemann U, Speedie MK, Hurley LH, Floss HG. Demonstration of a C-methylating enzyme in cell free extracts of indolmycin-producing Streptomycesgriseus Biochemical and Biophysical Research Communications. 39: 594-599. PMID 5490210 DOI: 10.1016/0006-291X(70)90245-7 |
0.554 |
|
| 1970 |
Hornemann U, Hurley LH, Speedie MK, Floss HG. Isolation and absolute configuration of indolmycenic acid, an intermediate in the biosynthesis of indolmycin by streptomyces griseus Tetrahedron Letters. 11: 2255-2258. PMID 5447649 DOI: 10.1016/S0040-4039(01)98202-4 |
0.562 |
|
| 1970 |
Floss HG, Onderka DK, Zalkin H. Mechanism of the anthranilate synthetase reaction. Evidence against an intramolecular hydrogen transfer. Biochimica Et Biophysica Acta. 206: 449-56. PMID 4918125 DOI: 10.1016/0005-2744(70)90160-9 |
0.389 |
|
| 1969 |
Onderka DK, Floss HG. Stereospecificity of the 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase reaction. Biochemical and Biophysical Research Communications. 35: 801-4. PMID 5791519 DOI: 10.1016/0006-291X(69)90694-9 |
0.349 |
|
| 1969 |
Hornemann U, Speedie MK, Kelley KM, Hurley LH, Floss HG. Biosynthesis of indoleisopropionic acid by Claviceps. Biological C-methylation involving an intact methyl group. Archives of Biochemistry and Biophysics. 131: 430-40. PMID 5787216 DOI: 10.1016/0003-9861(69)90415-9 |
0.571 |
|
| 1969 |
Floss HG, Guenther H, Groeger D, Erge D. Origin of the oxygen atoms in the conversion of anthranilic acid to 2,3-dihydroxybenzoic acid by Claviceps paspali. Archives of Biochemistry and Biophysics. 131: 319-20. PMID 5781730 DOI: 10.1016/0003-9861(69)90138-6 |
0.308 |
|
| 1969 |
Hornemann U, Hurley LH, Speedie MK, Guenther HF, Floss HG. Biosynthesis of the antibiotic indolmycin by Streptomyces griseus. C-Methylation at the β-carbon atom of the tryptophan side-chain Journal of the Chemical Society D: Chemical Communications. 245-246. DOI: 10.1039/C29690000245 |
0.525 |
|
| 1968 |
Floss HG, Hornemann U, Schilling N, Kelley K, Groeger D, Erge D. Biosynthesis of ergot alkaloids. Evidence for two isomerizations in the isoprenoid moiety during the formation of tetracyclic ergolines. Journal of the American Chemical Society. 90: 6500-7. PMID 5682448 DOI: 10.1021/Ja01025A048 |
0.325 |
|
| 1965 |
Floss HG, Hadwiger L, Conn EE. Enzymatic formation of beta-cyanoalanine from cyanide. Nature. 208: 1207-8. PMID 4958370 DOI: 10.1038/2081207A0 |
0.529 |
|
| 1964 |
WEYGAND F, FLOSS HG, MOTHES U, GROEGER D, MOTHES K. [ON THE BIOSYNTHESIS OF ERGOT ALKALOIDS. COMPARISON OF 2 POSSIBLE INTERMEDIATE PRODUCTS]. Zeitschrift FüR Naturforschung. Teil B: Chemie, Biochemie, Biophysik, Biologie. 19: 202-10. PMID 14174772 |
0.485 |
|
| 1960 |
GROEGER D, MOTHES K, SIMON H, FLOSS HG, WEYGAND F. [On the incorporation of mevalonic acid in the ergolin system of clavin alkaloids]. Zeitschrift FüR Naturforschung. Teil B: Chemie, Biochemie, Biophysik, Biologie. 15: 141-3. PMID 13851790 |
0.529 |
|
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