Christopher Lohans, Ph.D.

Affiliations: 
2014 University of Alberta, Edmonton, Alberta, Canada 
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Publications

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Lang PA, Raj R, Tumber A, et al. (2022) Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 119: e2117310119
Lucic A, Hinchliffe P, Malla TR, et al. (2021) Faropenem reacts with serine and metallo-β-lactamases to give multiple products. European Journal of Medicinal Chemistry. 215: 113257
Aertker KMJ, Chan HTH, Lohans CT, et al. (2020) Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism. The Journal of Biological Chemistry
Liu T, Abboud MI, Chowdhury R, et al. (2020) Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii. The Journal of Biological Chemistry
Cochrane SA, Lohans CT. (2020) Breaking down the cell wall: Strategies for antibiotic discovery targeting bacterial transpeptidases. European Journal of Medicinal Chemistry. 194: 112262
Holt-Martyn J, Chowdhury R, Tumber A, et al. (2019) Structure-Activity Relationship and Crystallographic Studies On 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors. Chemmedchem
Shaikh F, Zhao Y, Alvarez L, et al. (2019) Correction to "Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library". Journal of Medicinal Chemistry
Lohans CT, Freeman EI, Groesen EV, et al. (2019) Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation. Scientific Reports. 9: 13608
de Munnik M, Lohans CT, Lang PA, et al. (2019) Targeting the Mycobacterium tuberculosis transpeptidase Ldt with cysteine-reactive inhibitors including ebselen. Chemical Communications (Cambridge, England)
de Munnik M, Lohans CT, Langley GW, et al. (2019) A Fluorescence-based Assay for Screening β-Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2. Chembiochem : a European Journal of Chemical Biology
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