| Year |
Citation |
Score |
| 2022 |
Lang PA, Raj R, Tumber A, Lohans CT, Rabe P, Robinson CV, Brem J, Schofield CJ. Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 119: e2117310119. PMID 35486701 DOI: 10.1073/pnas.2117310119 |
0.47 |
|
| 2021 |
Lucic A, Hinchliffe P, Malla TR, Tooke CL, Brem J, Calvopiña K, Lohans CT, Rabe P, McDonough MA, Armistead T, Orville AM, Spencer J, Schofield CJ. Faropenem reacts with serine and metallo-β-lactamases to give multiple products. European Journal of Medicinal Chemistry. 215: 113257. PMID 33618159 DOI: 10.1016/j.ejmech.2021.113257 |
0.619 |
|
| 2020 |
Aertker KMJ, Chan HTH, Lohans CT, Schofield CJ. Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism. The Journal of Biological Chemistry. PMID 32963107 DOI: 10.1074/jbc.RA120.014607 |
0.451 |
|
| 2020 |
Liu T, Abboud MI, Chowdhury R, Tumber A, Hardy AP, Lippl K, Lohans CT, Pires E, Wickens J, McDonough MA, West CM, Schofield CJ. Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii. The Journal of Biological Chemistry. PMID 32934009 DOI: 10.1074/Jbc.Ra120.013998 |
0.72 |
|
| 2020 |
Cochrane SA, Lohans CT. Breaking down the cell wall: Strategies for antibiotic discovery targeting bacterial transpeptidases. European Journal of Medicinal Chemistry. 194: 112262. PMID 32248005 DOI: 10.1016/j.ejmech.2020.112262 |
0.721 |
|
| 2019 |
Holt-Martyn J, Chowdhury R, Tumber A, Yeh TL, Abboud MI, Lippl K, Lohans C, Langley G, McDonough M, Pugh C, Ratcliffe P, Schofield C. Structure-Activity Relationship and Crystallographic Studies On 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors. Chemmedchem. PMID 31751494 DOI: 10.1002/Cmdc.201900557 |
0.68 |
|
| 2019 |
Shaikh F, Zhao Y, Alvarez L, Iliopoulou M, Lohans C, Schofield CJ, Padilla-Parra S, Siu SWI, Fry EE, Ren J, Stuart DI. Correction to "Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library". Journal of Medicinal Chemistry. PMID 31657917 DOI: 10.1021/Acs.Jmedchem.9B01711 |
0.455 |
|
| 2019 |
Lohans CT, Freeman EI, Groesen EV, Tooke CL, Hinchliffe P, Spencer J, Brem J, Schofield CJ. Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation. Scientific Reports. 9: 13608. PMID 31541180 DOI: 10.1038/S41598-019-49264-0 |
0.421 |
|
| 2019 |
de Munnik M, Lohans CT, Lang PA, Langley GW, Malla TR, Tumber A, Schofield CJ, Brem J. Targeting the Mycobacterium tuberculosis transpeptidase Ldt with cysteine-reactive inhibitors including ebselen. Chemical Communications (Cambridge, England). PMID 31380528 DOI: 10.1039/C9Cc04145A |
0.423 |
|
| 2019 |
de Munnik M, Lohans CT, Langley GW, Bon C, Brem J, Schofield C. A Fluorescence-based Assay for Screening β-Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2. Chembiochem : a European Journal of Chemical Biology. PMID 31322798 DOI: 10.1002/Cbic.201900379 |
0.765 |
|
| 2019 |
Admiraal SJ, Eyler DE, Baldwin MR, Brines EM, Lohans CT, Schofield CJ, O'Brien PJ. Expansion of base excision repair compensates for a lack of DNA repair by oxidative dealkylation in budding yeast. The Journal of Biological Chemistry. PMID 31320474 DOI: 10.1074/Jbc.Ra119.009813 |
0.305 |
|
| 2019 |
van Groesen E, Lohans CT, Brem J, Aertker KM, Claridge TD, Schofield C. 19F-NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D β-Lactamase Carbamylation and Inhibition. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31310409 DOI: 10.1002/Chem.201902529 |
0.408 |
|
| 2019 |
Shaikh F, Zhao Y, Alvarez L, Iliopoulou M, Lohans CT, Schofield CJ, Padilla-Parra S, Siu SWI, Fry E, Ren J, Stuart DI. Structure-based In Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library. Journal of Medicinal Chemistry. PMID 30785281 DOI: 10.1021/Acs.Jmedchem.8B01328 |
0.451 |
|
| 2019 |
Cahill ST, Tyrrell JM, Navratilova IH, Calvopiña K, Robinson SW, Lohans CT, McDonough MA, Cain R, Fishwick CWG, Avison MB, Walsh TR, Schofield CJ, Brem J. Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates. Biochimica Et Biophysica Acta. General Subjects. PMID 30738906 DOI: 10.1016/J.Bbagen.2019.02.004 |
0.609 |
|
| 2019 |
Langley GW, Abboud MI, Lohans CT, Schofield CJ. Inhibition of a viral prolyl hydroxylase. Bioorganic & Medicinal Chemistry. PMID 30737136 DOI: 10.1016/J.Bmc.2019.01.018 |
0.378 |
|
| 2018 |
Lohans CT, Chan HTH, Malla TR, Kumar K, Kamps JJAG, McArdle DJB, van Groesen E, de Munnik M, Tooke CL, Spencer J, Paton RS, Brem J, Schofield C. Non-Hydrolytic β-Lactam Antibiotic Fragmentation by L,D-Transpeptidases and Serine β-Lactamase Cysteine Variants. Angewandte Chemie (International Ed. in English). PMID 30569575 DOI: 10.1002/Anie.201809424 |
0.449 |
|
| 2018 |
Thinnes CC, Lohans CT, Abboud MI, Yeh TL, Tumber A, Nowak RP, Attwood M, Cockman ME, Oppermann U, Loenarz C, Schofield C. Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30427558 DOI: 10.1002/Chem.201804790 |
0.696 |
|
| 2018 |
Rabe P, Kamps JJAG, Schofield CJ, Lohans CT. Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis. Natural Product Reports. PMID 29808887 DOI: 10.1039/C8Np00002F |
0.422 |
|
| 2017 |
Yeh TL, Leissing TM, Abboud MI, Thinnes CC, Atasoylu O, Holt-Martyn JP, Zhang D, Tumber A, Lippl K, Lohans CT, Leung IKH, Morcrette H, Clifton IJ, Claridge TDW, Kawamura A, et al. Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chemical Science. 8: 7651-7668. PMID 29435217 DOI: 10.1039/C7Sc02103H |
0.743 |
|
| 2017 |
Lohans CT, van Groesen E, Kumar K, Tooke CL, Spencer J, Paton RS, Brem J, Schofield C. A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems via Lactone Formation. Angewandte Chemie (International Ed. in English). PMID 29236332 DOI: 10.1002/Anie.201711308 |
0.441 |
|
| 2017 |
Lohans CT, Brem J, Schofield CJ. New Delhi metallo-β-lactamase-1 catalyses avibactam and aztreonam hydrolysis. Antimicrobial Agents and Chemotherapy. PMID 28971873 DOI: 10.1128/Aac.01224-17 |
0.412 |
|
| 2017 |
Calvopiña K, Hinchliffe P, Brem J, Heesom KJ, Johnson S, Cain R, Lohans CT, Fishwick CWG, Schofield CJ, Spencer J, Avison MB. Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. Molecular Microbiology. PMID 28876489 DOI: 10.1111/Mmi.13831 |
0.461 |
|
| 2017 |
Lohans CT, Wang DY, Jorgensen C, Cahill ST, Clifton IJ, McDonough MA, Oswin HP, Spencer J, Domene C, Claridge TDW, Brem J, Schofield CJ. (13)C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions. Organic & Biomolecular Chemistry. PMID 28678295 DOI: 10.1039/C7Ob01514C |
0.716 |
|
| 2017 |
Li GB, Brem J, Lesniak R, Abboud MI, Lohans CT, Clifton IJ, Yang SY, Jiménez-Castellanos JC, Avison MB, Spencer J, McDonough MA, Schofield CJ. Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition. Chemical Communications (Cambridge, England). PMID 28470248 DOI: 10.1039/C7Cc02394D |
0.766 |
|
| 2017 |
Li GB, Abboud MI, Brem J, Someya H, Lohans CT, Yang SY, Spencer J, Wareham DW, McDonough MA, Schofield CJ. NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors. Chemical Science. 8: 928-937. PMID 28451231 DOI: 10.1039/C6Sc04524C |
0.626 |
|
| 2017 |
Zhang Z, Smart TJ, Choi H, Hardy F, Lohans CT, Abboud MI, Richardson MSW, Paton RS, McDonough MA, Schofield CJ. Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate. Proceedings of the National Academy of Sciences of the United States of America. PMID 28420789 DOI: 10.1073/Pnas.1617760114 |
0.554 |
|
| 2017 |
Acedo JZ, Towle KM, Lohans CT, Miskolzie M, McKay RT, Doerksen TA, Vederas JC, Martin-Visscher LA. Identification and three-dimensional structure of carnobacteriocin XY, a class IIb bacteriocin produced by Carnobacteria. Febs Letters. PMID 28391617 DOI: 10.1002/1873-3468.12648 |
0.766 |
|
| 2017 |
Cahill ST, Cain R, Wang DY, Lohans CT, Wareham DW, Oswin HP, Mohammed J, Spencer J, Fishwick CW, McDonough MA, Schofield CJ, Brem J. Cyclic Boronates Inhibit All Classes of β-Lactamase. Antimicrobial Agents and Chemotherapy. PMID 28115348 DOI: 10.1128/Aac.02260-16 |
0.63 |
|
| 2017 |
Lohans CT, Wang DY, Wang J, Hamed RB, Schofield CJ. Crotonases: Nature’s Exceedingly Convertible Catalysts Acs Catalysis. 7: 6587-6599. DOI: 10.1021/Acscatal.7B01699 |
0.631 |
|
| 2016 |
Towle KM, Lohans CT, Miskolzie M, Acedo JZ, van Belkum MJ, Vederas JC. Solution Structures of Phenol-Soluble Modulins α1, α3, and β2, Virulence Factors from Staphylococcus aureus. Biochemistry. PMID 27525453 DOI: 10.1021/Acs.Biochem.6B00615 |
0.501 |
|
| 2016 |
Arbulu S, Frantzen C, Lohans CT, Cintas LM, Herranz C, Holo H, Diep DB, Vederas JC, Hernández PE. Draft Genome Sequence of the Bacteriocin-Producing Strain Enterococcus faecium M3K31, Isolated from Griffon Vultures (Gyps fulvus subsp. fulvus). Genome Announcements. 4. PMID 27013035 DOI: 10.1128/Genomea.00055-16 |
0.398 |
|
| 2016 |
Acedo JZ, van Belkum MJ, Lohans CT, Towle KM, Miskolzie M, Vederas JC. Nuclear Magnetic Resonance Solution Structures of Lacticin Q and Aureocin A53 Reveal a Structural Motif Conserved among Leaderless Bacteriocins with Broad-Spectrum Activity. Biochemistry. PMID 26771761 DOI: 10.1021/Acs.Biochem.5B01306 |
0.476 |
|
| 2015 |
Arbulu S, Lohans CT, Van Belkum MJ, Cintas LM, Herranz C, Vederas JC, Hernández PE. Solution Structure of Enterocin HF, an Antilisterial Bacteriocin Produced by Enterococcus faecium M3K31. Journal of Agricultural and Food Chemistry. PMID 26585399 DOI: 10.1021/Acs.Jafc.5B03882 |
0.484 |
|
| 2015 |
Cochrane SA, Lohans CT, van Belkum MJ, Bels MA, Vederas JC. Studies on tridecaptin B1, a lipopeptide with activity against multidrug resistant Gram-negative bacteria. Organic & Biomolecular Chemistry. 13: 6073-81. PMID 25959079 DOI: 10.1039/C5Ob00780A |
0.745 |
|
| 2015 |
van Belkum MJ, Lohans CT, Vederas JC. Draft Genome Sequences of Paenibacillus polymyxa NRRL B-30509 and Paenibacillus terrae NRRL B-30644, Strains from a Poultry Environment That Produce Tridecaptin A and Paenicidins. Genome Announcements. 3. PMID 25908148 DOI: 10.1128/Genomea.00372-15 |
0.396 |
|
| 2015 |
Acedo JZ, van Belkum MJ, Lohans CT, McKay RT, Miskolzie M, Vederas JC. Solution structure of acidocin B, a circular bacteriocin produced by Lactobacillus acidophilus M46. Applied and Environmental Microbiology. 81: 2910-8. PMID 25681186 DOI: 10.1128/Aem.04265-14 |
0.462 |
|
| 2015 |
Lin XB, Lohans CT, Duar R, Zheng J, Vederas JC, Walter J, Gänzle M. Genetic determinants of reutericyclin biosynthesis in Lactobacillus reuteri. Applied and Environmental Microbiology. 81: 2032-41. PMID 25576609 DOI: 10.1128/Aem.03691-14 |
0.435 |
|
| 2015 |
Lohans CT, Van Belkum MJ, Li J, Vederas JC. Characterization of bacterial antimicrobial peptides active against Campylobacter jejuni Canadian Journal of Chemistry. 93: 381-388. DOI: 10.1139/Cjc-2014-0411 |
0.503 |
|
| 2014 |
Lohans CT, Li JL, Vederas JC. Structure and biosynthesis of carnolysin, a homologue of enterococcal cytolysin with D-amino acids. Journal of the American Chemical Society. 136: 13150-3. PMID 25207953 DOI: 10.1021/Ja5070813 |
0.451 |
|
| 2014 |
Cochrane SA, Lohans CT, Brandelli JR, Mulvey G, Armstrong GD, Vederas JC. Synthesis and structure-activity relationship studies of N-terminal analogues of the antimicrobial peptide tridecaptin A(1). Journal of Medicinal Chemistry. 57: 1127-31. PMID 24479847 DOI: 10.1021/Jm401779D |
0.748 |
|
| 2014 |
Tulini FL, Lohans CT, Bordon KC, Zheng J, Arantes EC, Vederas JC, De Martinis EC. Purification and characterization of antimicrobial peptides from fish isolate Carnobacterium maltaromaticum C2: Carnobacteriocin X and carnolysins A1 and A2. International Journal of Food Microbiology. 173: 81-8. PMID 24412962 DOI: 10.1016/J.Ijfoodmicro.2013.12.019 |
0.468 |
|
| 2014 |
Lohans CT, van Belkum MJ, Cochrane SA, Huang Z, Sit CS, McMullen LM, Vederas JC. Biochemical, structural, and genetic characterization of tridecaptin A₁, an antagonist of Campylobacter jejuni. Chembiochem : a European Journal of Chemical Biology. 15: 243-9. PMID 24382692 DOI: 10.1002/Cbic.201300595 |
0.737 |
|
| 2014 |
Lohans CT, Vederas JC. Structural characterization of thioether-bridged bacteriocins. The Journal of Antibiotics. 67: 23-30. PMID 24022605 DOI: 10.1038/Ja.2013.81 |
0.478 |
|
| 2013 |
Lohans CT, Towle KM, Miskolzie M, McKay RT, van Belkum MJ, McMullen LM, Vederas JC. Solution structures of the linear leaderless bacteriocins enterocin 7A and 7B resemble carnocyclin A, a circular antimicrobial peptide. Biochemistry. 52: 3987-94. PMID 23725536 DOI: 10.1021/Bi400359Z |
0.503 |
|
| 2012 |
Lohans CT, Huang Z, van Belkum MJ, Giroud M, Sit CS, Steels EM, Zheng J, Whittal RM, McMullen LM, Vederas JC. Structural characterization of the highly cyclized lantibiotic paenicidin A via a partial desulfurization/reduction strategy. Journal of the American Chemical Society. 134: 19540-3. PMID 23167271 DOI: 10.1021/Ja3089229 |
0.768 |
|
| 2012 |
Lohans CT, Vederas JC. Development of Class IIa Bacteriocins as Therapeutic Agents. International Journal of Microbiology. 2012: 386410. PMID 22187559 DOI: 10.1155/2012/386410 |
0.45 |
|
| 2012 |
Sit CS, Lohans CT, van Belkum MJ, Campbell CD, Miskolzie M, Vederas JC. Substitution of a conserved disulfide in the type IIa bacteriocin, leucocin A, with L-leucine and L-serine residues: effects on activity and three-dimensional structure. Chembiochem : a European Journal of Chemical Biology. 13: 35-8. PMID 22121114 DOI: 10.1002/Cbic.201100634 |
0.705 |
|
| 2012 |
Sit C, Lohans C, Belkum Mv, Campbell C, Miskolzie M, Vederas J. C9L,C14L-LeuA Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Ljt/Pdb |
0.676 |
|
| 2012 |
Sit C, Lohans C, Belkum Mv, Campbell C, Miskolzie M, Vederas J. (C9S, C14S)-leucocin A Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr17955 |
0.691 |
|
| 2011 |
Martin-Visscher LA, Yoganathan S, Sit CS, Lohans CT, Vederas JC. The activity of bacteriocins from Carnobacterium maltaromaticum UAL307 against gram-negative bacteria in combination with EDTA treatment. Fems Microbiology Letters. 317: 152-9. PMID 21255070 DOI: 10.1111/J.1574-6968.2011.02223.X |
0.734 |
|
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