| Year |
Citation |
Score |
| 2023 |
Ye X, Yang W, Yi S, Zhao Y, Varani G, Jankowsky E, Yang F. Two distinct binding modes provide the RNA-binding protein RbFox with extraordinary sequence specificity. Nature Communications. 14: 701. PMID 36759600 DOI: 10.1038/s41467-023-36394-3 |
0.418 |
|
| 2022 |
Sharma S, Pisignano G, Merulla J, Catapano CV, Varani G. A functional SNP regulates E-cadherin expression by dynamically remodeling the 3D structure of a promoter-associated non-coding RNA transcript. Nucleic Acids Research. 50: 11331-11343. PMID 36243981 DOI: 10.1093/nar/gkac875 |
0.309 |
|
| 2022 |
Shortridge MD, Olsen GL, Yang W, Walker MJ, Varani G. A slow dynamic RNA switch regulates processing of microRNA-21. Journal of Molecular Biology. 167694. PMID 35752213 DOI: 10.1016/j.jmb.2022.167694 |
0.353 |
|
| 2022 |
Sun YT, Varani G. Structure of the Dengue Virus RNA Promoter. Rna (New York, N.Y.). PMID 35750488 DOI: 10.1261/rna.079197.122 |
0.382 |
|
| 2021 |
Shortridge MD, Varani G. Efficient NMR Screening Approach to Discover Small Molecule Fragments Binding Structured RNA. Acs Medicinal Chemistry Letters. 12: 1253-1260. PMID 34413954 DOI: 10.1021/acsmedchemlett.1c00109 |
0.304 |
|
| 2020 |
Sharma S, Varani G. NMR structure of Dengue West Nile viruses stem-loop B: A key cis-acting element for flavivirus replication. Biochemical and Biophysical Research Communications. PMID 32807496 DOI: 10.1016/J.Bbrc.2020.07.115 |
0.451 |
|
| 2020 |
Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, De Los Santos MC, Anfossi S, Shimizu M, Shah MY, Ling H, ... ... Varani G, et al. The Long Noncoding RNA CCAT2 induces chromosomal instability through BOP1 - AURKB signaling. Gastroenterology. PMID 32805281 DOI: 10.1053/J.Gastro.2020.08.018 |
0.364 |
|
| 2020 |
Longo LM, Despotović D, Weil-Ktorza O, Walker MJ, Jabłońska J, Fridmann-Sirkis Y, Varani G, Metanis N, Tawfik DS. Primordial emergence of a nucleic acid-binding protein via phase separation and statistical ornithine-to-arginine conversion. Proceedings of the National Academy of Sciences of the United States of America. PMID 32561643 DOI: 10.1073/Pnas.2001989117 |
0.361 |
|
| 2020 |
Jones AN, Pisignano G, Pavelitz T, White J, Kinisu M, Forino N, Dreycey A, Varani G. An evolutionarily-conserved RNA structure in the functional core of the lincRNA Cyrano. Rna (New York, N.Y.). PMID 32457084 DOI: 10.1261/Rna.076117.120 |
0.48 |
|
| 2020 |
Walker MJ, Shortridge MD, Albin DD, Cominsky LY, Varani G. Structure of the RNA specialized translation initiation element that recruits eIF3 to the 5'-UTR of c-Jun. Journal of Molecular Biology. PMID 31953146 DOI: 10.1016/J.Jmb.2020.01.001 |
0.491 |
|
| 2020 |
Barnwal RP, Kaur M, Heckert A, Gartia J, Varani G. Comparative structure, dynamics and evolution of acyl-carrier proteins from Borrelia burgdorferi, Brucella melitensis and Rickettsia prowazekii. The Biochemical Journal. PMID 31922183 DOI: 10.1042/Bcj20190797 |
0.333 |
|
| 2019 |
Smith KN, Miller SC, Varani G, Calabrese JM, Magnuson T. Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification. Genetics. 213: 1093-1110. PMID 31796550 DOI: 10.1534/Genetics.119.302661 |
0.405 |
|
| 2019 |
Fabbri M, Girnita L, Varani G, Calin GA. Decrypting noncoding RNA interactions, structures, and functional networks. Genome Research. PMID 31434680 DOI: 10.1101/Gr.247239.118 |
0.46 |
|
| 2019 |
Walker MJ, Varani G. Design of RNA-targeting macrocyclic peptides. Methods in Enzymology. 623: 339-372. PMID 31239053 DOI: 10.1016/Bs.Mie.2019.04.029 |
0.551 |
|
| 2019 |
Walker MJ, Varani G. An Allosteric Switch Primes Sequence-Specific DNA Recognition. Cell. 176: 4-6. PMID 30633906 DOI: 10.1016/J.Cell.2018.12.020 |
0.313 |
|
| 2018 |
Sun YT, Shortridge MD, Varani G. A small cyclic β-hairpin peptide mimics of the Rbfox2 RRM that binds to the precursor miRNA 20b. Chembiochem : a European Journal of Chemical Biology. PMID 30537200 DOI: 10.1002/Cbic.201800645 |
0.435 |
|
| 2018 |
Bochicchio A, Krepl M, Yang F, Varani G, Sponer J, Carloni P. Molecular basis for the increased affinity of an RNA recognition motif with re-engineered specificity: A molecular dynamics and enhanced sampling simulations study. Plos Computational Biology. 14: e1006642. PMID 30521520 DOI: 10.1371/Journal.Pcbi.1006642 |
0.495 |
|
| 2018 |
Romero Romero ML, Yang F, Lin YR, Toth-Petroczy A, Berezovsky IN, Goncearenco A, Yang W, Wellner A, Kumar-Deshmukh F, Sharon M, Baker D, Varani G, Tawfik DS. Simple yet functional phosphate-loop proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 30504143 DOI: 10.1073/Pnas.1812400115 |
0.392 |
|
| 2018 |
Shortridge MD, Wille PT, Jones AN, Davidson A, Bogdanovic J, Arts E, Karn J, Robinson JA, Varani G. An ultra-high affinity ligand of HIV-1 TAR reveals the RNA structure recognized by P-TEFb. Nucleic Acids Research. PMID 30481318 DOI: 10.2210/Pdb6D2U/Pdb |
0.705 |
|
| 2017 |
Hosseinzadeh P, Bhardwaj G, Mulligan VK, Shortridge MD, Craven TW, Pardo-Avila F, Rettie SA, Kim DE, Silva DA, Ibrahim YM, Webb IK, Cort JR, Adkins JN, Varani G, Baker D. Comprehensive computational design of ordered peptide macrocycles. Science (New York, N.Y.). 358: 1461-1466. PMID 29242347 DOI: 10.1126/Science.Aap7577 |
0.328 |
|
| 2017 |
Yang W, Hsu PL, Yang F, Song JE, Varani G. Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in recognition of 3'-end processing signals. Nucleic Acids Research. PMID 29186539 DOI: 10.1093/Nar/Gkx1177 |
0.426 |
|
| 2017 |
Barnwal RP, Yang F, Varani G. Applications of NMR to structure determination of RNAs large and small. Archives of Biochemistry and Biophysics. PMID 28600200 DOI: 10.1016/J.Abb.2017.06.003 |
0.537 |
|
| 2017 |
Pisignano G, Napoli S, Magistri M, Mapelli SN, Pastori C, Di Marco S, Civenni G, Albino D, Enriquez C, Allegrini S, Mitra A, D'Ambrosio G, Mello-Grand M, Chiorino G, Garcia-Escudero R, ... Varani G, et al. A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers. Nature Communications. 8: 15622. PMID 28555645 DOI: 10.1038/Ncomms15622 |
0.336 |
|
| 2017 |
Nemec CM, Yang F, Gilmore JM, Hintermair C, Ho YH, Tseng SC, Heidemann M, Zhang Y, Florens L, Gasch AP, Eick D, Washburn MP, Varani G, Ansari AZ. Different phosphoisoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner. Proceedings of the National Academy of Sciences of the United States of America. PMID 28465432 DOI: 10.1073/Pnas.1700128114 |
0.464 |
|
| 2017 |
Shortridge MD, Walker MJ, Pavelitz T, Chen Y, Varani G. A macrocyclic peptide ligand binds the oncogenic microRNA-21 precursor and suppresses Dicer processing. Acs Chemical Biology. PMID 28437065 DOI: 10.1021/Acschembio.7B00180 |
0.372 |
|
| 2017 |
Shortridge MD, Hosseinzadeh P, Pardo-Avila F, Varani G, Baker D. Solution structure of de novo macrocycle design12_ss Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb6Be7/Pdb |
0.301 |
|
| 2016 |
Abulwerdi FA, Shortridge MD, Sztuba-Solinska J, Wilson R, Le Grice SF, Varani G, Schneekloth JS. Development of Small Molecules with a Noncanonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA. Journal of Medicinal Chemistry. 59: 11148-11160. PMID 28002966 DOI: 10.1021/Acs.Jmedchem.6B01450 |
0.481 |
|
| 2016 |
Huang W, Emani PS, Varani G, Drobny GP. Ultraslow Domain Motions in HIV-1 TAR RNA Revealed by Solid-State Deuterium NMR. The Journal of Physical Chemistry. B. PMID 27930881 DOI: 10.1021/Acs.Jpcb.6B11041 |
0.466 |
|
| 2016 |
Yang F, Hsu P, Lee SD, Yang W, Xu W, Moore C, Varani G. The C-terminus of Pcf11 forms a novel zinc-finger structure that plays an essential role in mRNA 3'- end processing. Rna (New York, N.Y.). PMID 27780845 DOI: 10.1261/Rna.058354.116 |
0.448 |
|
| 2016 |
Chen Y, Yang F, Zubovic L, Pavelitz T, Yang W, Godin K, Walker M, Zheng S, Macchi P, Varani G. Targeted inhibition of oncogenic miR-21 maturation with designed RNA-binding proteins. Nature Chemical Biology. PMID 27428511 DOI: 10.1038/Nchembio.2128 |
0.392 |
|
| 2016 |
Barnwal RP, Loh E, Godin KS, Yip J, Lavender H, Tang CM, Varani G. Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis. Nucleic Acids Research. PMID 27369378 DOI: 10.1093/Nar/Gkw584 |
0.426 |
|
| 2016 |
Borkar AN, Bardaro MF, Camilloni C, Aprile FA, Varani G, Vendruscolo M. Structure of a low-population binding intermediate in protein-RNA recognition. Proceedings of the National Academy of Sciences of the United States of America. PMID 27286828 DOI: 10.1073/Pnas.1521349113 |
0.855 |
|
| 2016 |
Barnwal R, Godin K, Varani G. NMR Assignment and structure of CssA5 (middle region) of CssA thermometer from Neisseria meningitidis Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2N6X/Pdb |
0.312 |
|
| 2016 |
Barnwal R, Godin K, Varani G. NMR Assignment and structure of CssA Thermometer from Neisseria meningitidis Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2N6W/Pdb |
0.334 |
|
| 2015 |
Varani G. Twenty years of RNA: the discovery of microRNAs. Rna (New York, N.Y.). 21: 751-2. PMID 25780221 DOI: 10.1261/Rna.050237.115 |
0.521 |
|
| 2015 |
Shortridge MD, Varani G. Structure based approaches for targeting non-coding RNAs with small molecules. Current Opinion in Structural Biology. 30: 79-88. PMID 25687935 DOI: 10.1016/J.Sbi.2015.01.008 |
0.48 |
|
| 2015 |
Bottini A, De SK, Wu B, Tang C, Varani G, Pellecchia M. Targeting Influenza A Virus RNA Promoter. Chemical Biology & Drug Design. PMID 25676805 DOI: 10.1111/Cbdd.12534 |
0.407 |
|
| 2014 |
Lee MK, Bottini A, Kim M, Bardaro MF, Zhang Z, Pellecchia M, Choi BS, Varani G. Correction: A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication. Chemical Communications (Cambridge, England). 50: 12578. PMID 26037260 DOI: 10.1039/C4Cc90361G |
0.805 |
|
| 2014 |
Musiani F, Rossetti G, Capece L, Gerger TM, Micheletti C, Varani G, Carloni P. Molecular dynamics simulations identify time scale of conformational changes responsible for conformational selection in molecular recognition of HIV-1 transactivation responsive RNA. Journal of the American Chemical Society. 136: 15631-7. PMID 25313638 DOI: 10.1021/Ja507812V |
0.426 |
|
| 2014 |
Hsu PL, Yang F, Smith-Kinnaman W, Yang W, Song JE, Mosley AL, Varani G. Rtr1 is a dual specificity phosphatase that dephosphorylates Tyr1 and Ser5 on the RNA polymerase II CTD. Journal of Molecular Biology. 426: 2970-81. PMID 24951832 DOI: 10.1016/J.Jmb.2014.06.010 |
0.43 |
|
| 2014 |
Smith-Kinnaman WR, Berna MJ, Hunter GO, True JD, Hsu P, Cabello GI, Fox MJ, Varani G, Mosley AL. The interactome of the atypical phosphatase Rtr1 in Saccharomyces cerevisiae. Molecular Biosystems. 10: 1730-41. PMID 24671508 DOI: 10.1039/C4Mb00109E |
0.39 |
|
| 2014 |
Emani PS, Bardaro MF, Huang W, Aragon S, Varani G, Drobny GP. Elucidating molecular motion through structural and dynamic filters of energy-minimized conformer ensembles. The Journal of Physical Chemistry. B. 118: 1726-42. PMID 24479561 DOI: 10.1021/Jp409386T |
0.843 |
|
| 2014 |
Lee MK, Bottini A, Kim M, Bardaro MF, Zhang Z, Pellecchia M, Choi BS, Varani G. A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication. Chemical Communications (Cambridge, England). 50: 368-70. PMID 24247110 DOI: 10.1039/C3Cc46973E |
0.825 |
|
| 2013 |
Do TN, Carloni P, Varani G, Bussi G. RNA/Peptide Binding Driven by Electrostatics-Insight from Bidirectional Pulling Simulations. Journal of Chemical Theory and Computation. 9: 1720-30. PMID 26587630 DOI: 10.1021/Ct3009914 |
0.497 |
|
| 2013 |
Chen Y, Varani G. Engineering RNA-binding proteins for biology. The Febs Journal. 280: 3734-54. PMID 23742071 DOI: 10.1111/Febs.12375 |
0.558 |
|
| 2013 |
Varani G. 200 Potent inhibition of HIV replication by RNA-binding peptide mimetics with unprecedented specificity Journal of Biomolecular Structure & Dynamics. 31: 131-131. DOI: 10.1080/07391102.2013.786443 |
0.466 |
|
| 2013 |
Do TN, Carloni P, Varani G, Bussi G. RNA/peptide binding driven by electrostatics - Insight from bidirectional pulling simulations Journal of Chemical Theory and Computation. 9: 1720-1730. DOI: 10.1021/ct3009914 |
0.349 |
|
| 2012 |
Do TN, Ippoliti E, Carloni P, Varani G, Parrinello M. Counterion Redistribution upon Binding of a Tat-Protein Mimic to HIV-1 TAR RNA. Journal of Chemical Theory and Computation. 8: 688-94. PMID 26596616 DOI: 10.1021/Ct2005769 |
0.534 |
|
| 2012 |
Barnwal RP, Lee SD, Moore C, Varani G. Structural and biochemical analysis of the assembly and function of the yeast pre-mRNA 3' end processing complex CF I. Proceedings of the National Academy of Sciences of the United States of America. 109: 21342-7. PMID 23236150 DOI: 10.1073/Pnas.1214102110 |
0.548 |
|
| 2012 |
Kim H, Lee MK, Ko J, Park CJ, Kim M, Jeong Y, Hong S, Varani G, Choi BS. Aminoglycoside antibiotics bind to the influenza A virus RNA promoter. Molecular Biosystems. 8: 2857-9. PMID 22990985 DOI: 10.1039/C2Mb25333J |
0.373 |
|
| 2012 |
Huang W, Bardaro MF, Varani G, Drobny GP. Preparation of RNA samples with narrow line widths for solid state NMR investigations. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 223: 51-4. PMID 22967888 DOI: 10.1016/J.Jmr.2012.07.018 |
0.826 |
|
| 2012 |
Bardaro MF, Varani G. Independent alignment of RNA for dynamic studies using residual dipolar couplings. Journal of Biomolecular Nmr. 54: 69-80. PMID 22806132 DOI: 10.1007/S10858-012-9655-0 |
0.845 |
|
| 2012 |
Emani PS, Olsen GL, Varani G, Drobny GP. Correction to "Theory of nonrigid rotational motion applied to NMR relaxation in RNA". The Journal of Physical Chemistry. A. 116: 7253-60. PMID 22721263 DOI: 10.1021/Jp305123N |
0.31 |
|
| 2012 |
Bardaro MF, Varani G. Examining the relationship between RNA function and motion using nuclear magnetic resonance. Wiley Interdisciplinary Reviews. Rna. 3: 122-32. PMID 22180312 DOI: 10.1002/Wrna.108 |
0.84 |
|
| 2012 |
Do TN, Ippoliti E, Carloni P, Varani G, Parrinello M. Counterion redistribution upon binding of a tat-protein mimic to HIV-1 TAR RNA Journal of Chemical Theory and Computation. 8: 688-694. DOI: 10.1021/ct2005769 |
0.368 |
|
| 2011 |
Walbott H, Machado-Pinilla R, Liger D, Blaud M, Réty S, Grozdanov PN, Godin K, van Tilbeurgh H, Varani G, Meier UT, Leulliot N. The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic. Genes & Development. 25: 2398-408. PMID 22085966 DOI: 10.1101/Gad.176834.111 |
0.546 |
|
| 2011 |
Huang W, Varani G, Drobny GP. Interactions of protein side chains with RNA defined with REDOR solid state NMR. Journal of Biomolecular Nmr. 51: 347-56. PMID 21947838 DOI: 10.1007/S10858-011-9573-6 |
0.492 |
|
| 2011 |
Leeper T, Zhang S, Van Voorhis WC, Myler PJ, Varani G. Comparative analysis of glutaredoxin domains from bacterial opportunistic pathogens. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1141-7. PMID 21904064 DOI: 10.1107/S1744309111012346 |
0.719 |
|
| 2011 |
Barnwal RP, Van Voorhis WC, Varani G. NMR structure of an acyl-carrier protein from Borrelia burgdorferi. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1137-40. PMID 21904063 DOI: 10.1107/S1744309111004386 |
0.372 |
|
| 2011 |
Stacy R, Begley DW, Phan I, Staker BL, Van Voorhis WC, Varani G, Buchko GW, Stewart LJ, Myler PJ. Structural genomics of infectious disease drug targets: the SSGCID. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 979-84. PMID 21904037 DOI: 10.1107/S1744309111029204 |
0.739 |
|
| 2011 |
Emani PS, Olsen GL, Varani G, Drobny GP. Theory of nonrigid rotational motion applied to NMR relaxation in RNA. The Journal of Physical Chemistry. A. 115: 12055-69. PMID 21870804 DOI: 10.1021/Jp204499X |
0.438 |
|
| 2011 |
Niu Y, Jones AJ, Wu H, Varani G, Cai J. γ-AApeptides bind to RNA by mimicking RNA-binding proteins. Organic & Biomolecular Chemistry. 9: 6604-9. PMID 21826330 DOI: 10.1039/C1Ob05738C |
0.548 |
|
| 2011 |
Chen Y, Varani G. Finding the missing code of RNA recognition by PUF proteins. Chemistry & Biology. 18: 821-3. PMID 21802002 DOI: 10.1016/J.Chembiol.2011.07.001 |
0.39 |
|
| 2011 |
Davidson A, Begley DW, Lau C, Varani G. A small-molecule probe induces a conformation in HIV TAR RNA capable of binding drug-like fragments. Journal of Molecular Biology. 410: 984-96. PMID 21763501 DOI: 10.1016/J.Jmb.2011.03.039 |
0.832 |
|
| 2011 |
Lalonde MS, Lobritz MA, Ratcliff A, Chamanian M, Athanassiou Z, Tyagi M, Wong J, Robinson JA, Karn J, Varani G, Arts EJ. Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA. Plos Pathogens. 7: e1002038. PMID 21625572 DOI: 10.1371/Journal.Ppat.1002038 |
0.409 |
|
| 2011 |
Norville IH, O'Shea K, Sarkar-Tyson M, Zheng S, Titball RW, Varani G, Harmer NJ. The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development. The Biochemical Journal. 437: 413-22. PMID 21574961 DOI: 10.1042/Bj20110345 |
0.397 |
|
| 2011 |
Davidson A, Patora-Komisarska K, Robinson JA, Varani G. Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein. Nucleic Acids Research. 39: 248-56. PMID 20724442 DOI: 10.1093/Nar/Gkq713 |
0.719 |
|
| 2011 |
Bardaro MF, Pederson K, Drobny G, Varani G. Investigating RNA and DNA dynamics through nuclear magnetic resonance Advances in Biomedical Spectroscopy. 3: 279-301. DOI: 10.3233/978-1-60750-695-9-279 |
0.795 |
|
| 2010 |
Huang W, Varani G, Drobny GP. 13C/15N-19F intermolecular REDOR NMR study of the interaction of TAR RNA with Tat peptides. Journal of the American Chemical Society. 132: 17643-5. PMID 21105680 DOI: 10.1021/Ja1051439 |
0.448 |
|
| 2010 |
Emani PS, Olsen GL, Echodu DC, Varani G, Drobny GP. Slow exchange model of nonrigid rotational motion in RNA for combined solid-state and solution NMR studies. The Journal of Physical Chemistry. B. 114: 15991-6002. PMID 21067190 DOI: 10.1021/Jp107193Z |
0.534 |
|
| 2010 |
Lunde BM, Reichow SL, Kim M, Suh H, Leeper TC, Yang F, Mutschler H, Buratowski S, Meinhart A, Varani G. Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain. Nature Structural & Molecular Biology. 17: 1195-201. PMID 20818393 DOI: 10.1038/Nsmb.1893 |
0.807 |
|
| 2010 |
Begley DW, Zheng S, Varani G. Fragment-based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping. Chemical Biology & Drug Design. 76: 218-33. PMID 20626411 DOI: 10.1111/J.1747-0285.2010.01010.X |
0.767 |
|
| 2010 |
Leeper TC, Qu X, Lu C, Moore C, Varani G. Novel protein-protein contacts facilitate mRNA 3'-processing signal recognition by Rna15 and Hrp1. Journal of Molecular Biology. 401: 334-49. PMID 20600122 DOI: 10.1016/J.Jmb.2010.06.032 |
0.792 |
|
| 2010 |
Lee MK, Gal M, Frydman L, Varani G. Real-time multidimensional NMR follows RNA folding with second resolution. Proceedings of the National Academy of Sciences of the United States of America. 107: 9192-7. PMID 20439766 DOI: 10.1073/Pnas.1001195107 |
0.507 |
|
| 2010 |
Olsen GL, Bardaro MF, Echodu DC, Drobny GP, Varani G. Intermediate rate atomic trajectories of RNA by solid-state NMR spectroscopy. Journal of the American Chemical Society. 132: 303-8. PMID 19994901 DOI: 10.1021/Ja907515S |
0.85 |
|
| 2010 |
Lunde B, Reichow S, Kim M, Suh H, Leeper T, Yang F, Mutschler H, Buratowski S, Meinhart A, Varani G. Solution structure of Rtt103 CTD-interacting domain bound to a Ser2 phosphorylated CTD peptide Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2L0I/Pdb |
0.77 |
|
| 2010 |
Lunde B, Reichow S, Kim M, Leeper T, Becker R, Buratowski S, Meinhart A, Varani G. Solution structure of Rtt103 CTD interacting domain Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Km4/Pdb |
0.769 |
|
| 2010 |
Zheng S, Barnwal RP, Leeper T, Varani G. Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with 1-{[(4-methylphenyl)thio]acetyl}piperidine. Seattle Structure Genomics Center for Infectious Disease (SSGCID) Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr17151 |
0.684 |
|
| 2009 |
Begley DW, Varani G. Locking out viral replication. Nature Chemical Biology. 5: 782-3. PMID 19841624 DOI: 10.1038/Nchembio.245 |
0.802 |
|
| 2009 |
Liu Y, Peacey E, Dickson J, Donahue CP, Zheng S, Varani G, Wolfe MS. Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA. Journal of Medicinal Chemistry. 52: 6523-6. PMID 19839622 DOI: 10.1021/Jm9013407 |
0.342 |
|
| 2009 |
Olsen GL, Bardaro MF, Echodu DC, Drobny GP, Varani G. Hydration dependent dynamics in RNA. Journal of Biomolecular Nmr. 45: 133-42. PMID 19669102 DOI: 10.1007/S10858-009-9355-6 |
0.833 |
|
| 2009 |
Davidson A, Leeper TC, Athanassiou Z, Patora-Komisarska K, Karn J, Robinson JA, Varani G. Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein. Proceedings of the National Academy of Sciences of the United States of America. 106: 11931-6. PMID 19584251 DOI: 10.1073/Pnas.0900629106 |
0.838 |
|
| 2009 |
Zheng S, Chen Y, Donahue CP, Wolfe MS, Varani G. Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone). Chemistry & Biology. 16: 557-66. PMID 19477420 DOI: 10.1016/J.Chembiol.2009.03.009 |
0.461 |
|
| 2009 |
Godin KS, Walbott H, Leulliot N, van Tilbeurgh H, Varani G. The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme. Journal of Molecular Biology. 390: 231-44. PMID 19426738 DOI: 10.1016/J.Jmb.2009.04.076 |
0.458 |
|
| 2009 |
Bardaro MF, Shajani Z, Patora-Komisarska K, Robinson JA, Varani G. How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape. Nucleic Acids Research. 37: 1529-40. PMID 19139066 DOI: 10.1093/Nar/Gkn1074 |
0.82 |
|
| 2009 |
Zheng S, Leeper T, Varani G. Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei. Seattle Structure Genomics Center for Infectious Disease (SSGCID) Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16406 |
0.682 |
|
| 2009 |
Zheng S, Leeper T, Varani G. Solution structure of Glutaredoxin from Brucella melitensis. Seattle Structure Genomics Center for Infectious Disease (SSGCID) (Target ID BrabA.00079.a) Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16264 |
0.687 |
|
| 2009 |
Heikaus CC, Martinez SE, Varani G, Beavo JA, Klevit RE. Structural and Biophysical Characterization of the GAF Domains from Phosphodiesterases 5 and 6 Biophysical Journal. 96: 547a. DOI: 10.1016/J.Bpj.2008.12.2963 |
0.411 |
|
| 2008 |
Echodu D, Goobes G, Shajani Z, Pederson K, Meints G, Varani G, Drobny G. Furanose dynamics in the HhaI methyltransferase target DNA studied by solution and solid-state NMR relaxation. The Journal of Physical Chemistry. B. 112: 13934-44. PMID 18844399 DOI: 10.1021/Jp801723X |
0.759 |
|
| 2008 |
Chen Y, Mandic J, Varani G. Cell-free selection of RNA-binding proteins using in vitro compartmentalization. Nucleic Acids Research. 36: e128. PMID 18790803 DOI: 10.1093/Nar/Gkn559 |
0.479 |
|
| 2008 |
Gherghe CM, Shajani Z, Wilkinson KA, Varani G, Weeks KM. Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA. Journal of the American Chemical Society. 130: 12244-5. PMID 18710236 DOI: 10.1021/Ja804541S |
0.837 |
|
| 2008 |
Shajani Z, Varani G. 13C relaxation studies of the DNA target sequence for hhai methyltransferase reveal unique motional properties. Biochemistry. 47: 7617-25. PMID 18578505 DOI: 10.1021/Bi7020469 |
0.764 |
|
| 2008 |
Reichow SL, Varani G. Nop10 is a conserved H/ACA snoRNP molecular adaptor. Biochemistry. 47: 6148-56. PMID 18473479 DOI: 10.1021/Bi800418P |
0.781 |
|
| 2008 |
Liu J, Begley D, Mitchell DD, Verlinde CL, Varani G, Fan E. Multivalent drug design and inhibition of cholera toxin by specific and transient protein-ligand interactions. Chemical Biology & Drug Design. 71: 408-19. PMID 18373548 DOI: 10.1111/J.1747-0285.2008.00648.X |
0.76 |
|
| 2008 |
Olsen GL, Echodu DC, Shajani Z, Bardaro MF, Varani G, Drobny GP. Solid-state deuterium NMR studies reveal micros-ns motions in the HIV-1 transactivation response RNA recognition site. Journal of the American Chemical Society. 130: 2896-7. PMID 18275190 DOI: 10.1021/Ja0778803 |
0.828 |
|
| 2008 |
Deka P, Bucheli ME, Moore C, Buratowski S, Varani G. Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals. Journal of Molecular Biology. 375: 136-50. PMID 18022637 DOI: 10.1016/J.Jmb.2007.09.029 |
0.741 |
|
| 2007 |
Zheng S, Robertson TA, Varani G. A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins. The Febs Journal. 274: 6378-91. PMID 18005254 DOI: 10.1111/J.1742-4658.2007.06155.X |
0.738 |
|
| 2007 |
Moehle K, Athanassiou Z, Patora K, Davidson A, Varani G, Robinson JA. Design of beta-hairpin peptidomimetics that inhibit binding of alpha-helical HIV-1 Rev protein to the rev response element RNA. Angewandte Chemie (International Ed. in English). 46: 9101-4. PMID 17893894 DOI: 10.1002/Anie.200702801 |
0.682 |
|
| 2007 |
Godin KS, Varani G. How arginine-rich domains coordinate mRNA maturation events. Rna Biology. 4: 69-75. PMID 17873524 DOI: 10.4161/Rna.4.2.4869 |
0.458 |
|
| 2007 |
Leulliot N, Godin KS, Hoareau-Aveilla C, Quevillon-Cheruel S, Varani G, Henry Y, Van Tilbeurgh H. The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p. Journal of Molecular Biology. 371: 1338-53. PMID 17612558 DOI: 10.1016/J.Jmb.2007.06.031 |
0.454 |
|
| 2007 |
Lunde BM, Moore C, Varani G. RNA-binding proteins: modular design for efficient function. Nature Reviews. Molecular Cell Biology. 8: 479-90. PMID 17473849 DOI: 10.1038/Nrm2178 |
0.848 |
|
| 2007 |
Shajani Z, Drobny G, Varani G. Binding of U1A protein changes RNA dynamics as observed by 13C NMR relaxation studies. Biochemistry. 46: 5875-83. PMID 17469848 DOI: 10.1021/Bi602658X |
0.845 |
|
| 2007 |
Watters AL, Deka P, Corrent C, Callender D, Varani G, Sosnick T, Baker D. The highly cooperative folding of small naturally occurring proteins is likely the result of natural selection. Cell. 128: 613-24. PMID 17289578 DOI: 10.1016/J.Cell.2006.12.042 |
0.607 |
|
| 2007 |
Reichow SL, Hamma T, Ferré-D'Amaré AR, Varani G. The structure and function of small nucleolar ribonucleoproteins. Nucleic Acids Research. 35: 1452-64. PMID 17284456 DOI: 10.1093/Nar/Gkl1172 |
0.779 |
|
| 2007 |
Athanassiou Z, Patora K, Dias RL, Moehle K, Robinson JA, Varani G. Structure-guided peptidomimetic design leads to nanomolar beta-hairpin inhibitors of the Tat-TAR interaction of bovine immunodeficiency virus. Biochemistry. 46: 741-51. PMID 17223695 DOI: 10.1021/Bi0619371 |
0.494 |
|
| 2007 |
Dantas G, Corrent C, Reichow SL, Havranek JJ, Eletr ZM, Isern NG, Kuhlman B, Varani G, Merritt EA, Baker D. High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design. Journal of Molecular Biology. 366: 1209-21. PMID 17196978 DOI: 10.1016/J.Jmb.2006.11.080 |
0.711 |
|
| 2007 |
Shajani Z, Varani G. NMR studies of dynamics in RNA and DNA by 13C relaxation. Biopolymers. 86: 348-59. PMID 17154290 DOI: 10.1002/Bip.20650 |
0.803 |
|
| 2007 |
Qu X, Perez-Canadillas JM, Agrawal S, De Baecke J, Cheng H, Varani G, Moore C. The C-terminal domains of vertebrate CstF-64 and its yeast orthologue Rna15 form a new structure critical for mRNA 3'-end processing. The Journal of Biological Chemistry. 282: 2101-15. PMID 17116658 DOI: 10.1074/Jbc.M609981200 |
0.528 |
|
| 2007 |
Robertson TA, Varani G. An all-atom, distance-dependent scoring function for the prediction of protein-DNA interactions from structure. Proteins. 66: 359-74. PMID 17078093 DOI: 10.1002/Prot.21162 |
0.62 |
|
| 2007 |
Moehle K, Athanassiou Z, Patora K, Davidson A, Varani G, Robinson J. Design von β-Haarnadel-Peptidmimetika zur Hemmung der Bindung des α-helicalen HIV-1-Rev-Proteins an das Rev-RNA-Erkennungselement Angewandte Chemie. 119: 9260-9264. DOI: 10.1002/Ange.200702801 |
0.637 |
|
| 2006 |
Miller PA, Shajani Z, Meints GA, Caplow D, Goobes G, Varani G, Drobny GP. Contrasting views of the internal dynamics of the HhaI methyltransferase target DNA reported by solution and solid-state NMR spectroscopy. Journal of the American Chemical Society. 128: 15970-1. PMID 17165714 DOI: 10.1021/Ja066329N |
0.761 |
|
| 2006 |
Dantas G, Watters AL, Lunde BM, Eletr ZM, Isern NG, Roseman T, Lipfert J, Doniach S, Tompa M, Kuhlman B, Stoddard BL, Varani G, Baker D. Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution. Journal of Molecular Biology. 362: 1004-24. PMID 16949611 DOI: 10.1016/J.Jmb.2006.07.092 |
0.797 |
|
| 2006 |
Shajani Z, Deka P, Varani G. Decoding RNA motional codes. Trends in Biochemical Sciences. 31: 421-4. PMID 16815707 DOI: 10.1016/J.Tibs.2006.06.002 |
0.847 |
|
| 2006 |
Reichow S, Varani G. Structural biology: RNA switches function. Nature. 441: 1054-5. PMID 16810234 DOI: 10.1038/4411054A |
0.798 |
|
| 2006 |
Chen Y, Fender J, Legassie JD, Jarstfer MB, Bryan TM, Varani G. Structure of stem-loop IV of Tetrahymena telomerase RNA. The Embo Journal. 25: 3156-66. PMID 16778765 DOI: 10.1038/Sj.Emboj.7601195 |
0.517 |
|
| 2006 |
Dobson N, Dantas G, Baker D, Varani G. High-resolution structural validation of the computational redesign of human U1A protein. Structure (London, England : 1993). 14: 847-56. PMID 16698546 DOI: 10.1016/J.Str.2006.02.011 |
0.346 |
|
| 2005 |
Hamma T, Reichow SL, Varani G, Ferré-D'Amaré AR. The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs. Nature Structural & Molecular Biology. 12: 1101-7. PMID 16286935 DOI: 10.1038/Nsmb1036 |
0.793 |
|
| 2005 |
Dobson N, Dantas G, Varani G. 1H, 13C and 15N resonance assignments of URNdesign, a computationally redesigned RRM protein. Journal of Biomolecular Nmr. 33: 135. PMID 16258832 DOI: 10.1007/S10858-005-1928-4 |
0.314 |
|
| 2005 |
Leeper TC, Athanassiou Z, Dias RL, Robinson JA, Varani G. TAR RNA recognition by a cyclic peptidomimetic of Tat protein. Biochemistry. 44: 12362-72. PMID 16156649 DOI: 10.1021/Bi0510532 |
0.797 |
|
| 2005 |
Olsen GL, Edwards TE, Deka P, Varani G, Sigurdsson ST, Drobny GP. Monitoring tat peptide binding to TAR RNA by solid-state 31P-19F REDOR NMR. Nucleic Acids Research. 33: 3447-54. PMID 15961729 DOI: 10.1093/Nar/Gki626 |
0.713 |
|
| 2005 |
Shajani Z, Varani G. 13C NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein. Journal of Molecular Biology. 349: 699-715. PMID 15890361 DOI: 10.1016/J.Jmb.2005.04.012 |
0.836 |
|
| 2005 |
Chen Y, Varani G. Protein families and RNA recognition. The Febs Journal. 272: 2088-97. PMID 15853794 DOI: 10.1111/J.1742-4658.2005.04650.X |
0.566 |
|
| 2005 |
Deka P, Rajan PK, Perez-Canadillas JM, Varani G. Protein and RNA dynamics play key roles in determining the specific recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein. Journal of Molecular Biology. 347: 719-33. PMID 15769465 DOI: 10.1016/J.Jmb.2005.01.046 |
0.743 |
|
| 2005 |
Leeper TC, Varani G. The structure of an enzyme-activating fragment of human telomerase RNA. Rna (New York, N.Y.). 11: 394-403. PMID 15703438 DOI: 10.1261/Rna.7222505 |
0.779 |
|
| 2005 |
Varani G. How proteins and RNA recognize each other Febs Journal. 272: 2087. DOI: 10.1111/J.1742-4658.2005.04701.X |
0.507 |
|
| 2004 |
Chen Y, Kortemme T, Robertson T, Baker D, Varani G. A new hydrogen-bonding potential for the design of protein-RNA interactions predicts specific contacts and discriminates decoys. Nucleic Acids Research. 32: 5147-62. PMID 15459285 DOI: 10.1093/Nar/Gkh785 |
0.695 |
|
| 2004 |
Varani G, Chen Y, Leeper TC. NMR studies of protein-nucleic acid interactions. Methods in Molecular Biology (Clifton, N.J.). 278: 289-312. PMID 15318001 DOI: 10.1385/1-59259-809-9:289 |
0.747 |
|
| 2004 |
Detering C, Varani G. Validation of automated docking programs for docking and database screening against RNA drug targets. Journal of Medicinal Chemistry. 47: 4188-201. PMID 15293991 DOI: 10.1021/Jm030650O |
0.54 |
|
| 2004 |
Leulliot N, Quevillon-Cheruel S, Graille M, van Tilbeurgh H, Leeper TC, Godin KS, Edwards TE, Sigurdsson ST, Rozenkrants N, Nagel RJ, Ares M, Varani G. A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III. The Embo Journal. 23: 2468-77. PMID 15192703 DOI: 10.1038/Sj.Emboj.7600260 |
0.799 |
|
| 2004 |
Athanassiou Z, Dias RL, Moehle K, Dobson N, Varani G, Robinson JA. Structural mimicry of retroviral tat proteins by constrained beta-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements. Journal of the American Chemical Society. 126: 6906-13. PMID 15174860 DOI: 10.1021/Ja0497680 |
0.526 |
|
| 2004 |
Davis B, Afshar M, Varani G, Murchie AI, Karn J, Lentzen G, Drysdale M, Bower J, Potter AJ, Starkey ID, Swarbrick T, Aboul-ela F. Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots". Journal of Molecular Biology. 336: 343-56. PMID 14757049 DOI: 10.1016/J.Jmb.2003.12.046 |
0.565 |
|
| 2003 |
Kuhlman B, Dantas G, Ireton GC, Varani G, Stoddard BL, Baker D. Design of a novel globular protein fold with atomic-level accuracy. Science (New York, N.Y.). 302: 1364-8. PMID 14631033 DOI: 10.1126/Science.1089427 |
0.32 |
|
| 2003 |
Pérez Cañadillas JM, Varani G. Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein. The Embo Journal. 22: 2821-30. PMID 12773396 DOI: 10.1093/Emboj/Cdg259 |
0.564 |
|
| 2003 |
Park CJ, Bae SH, Lee MK, Varani G, Choi BS. Solution structure of the influenza A virus cRNA promoter: implications for differential recognition of viral promoter structures by RNA-dependent RNA polymerase. Nucleic Acids Research. 31: 2824-32. PMID 12771209 DOI: 10.1093/Nar/Gkg387 |
0.536 |
|
| 2003 |
Varani G, Ramos A. Splicing factor 1 in the pocket. Structure (London, England : 1993). 11: 481-2. PMID 12737811 DOI: 10.1016/S0969-2126(03)00079-0 |
0.364 |
|
| 2003 |
Leeper T, Leulliot N, Varani G. The solution structure of an essential stem-loop of human telomerase RNA. Nucleic Acids Research. 31: 2614-21. PMID 12736311 DOI: 10.1093/Nar/Gkg351 |
0.786 |
|
| 2002 |
Castrignanò T, Chillemi G, Varani G, Desideri A. Molecular dynamics simulation of the RNA complex of a double-stranded RNA-binding domain reveals dynamic features of the intermolecular interface and its hydration. Biophysical Journal. 83: 3542-52. PMID 12496121 DOI: 10.1016/S0006-3495(02)75354-X |
0.564 |
|
| 2002 |
Greatorex J, Gallego J, Varani G, Lever A. Structure and stability of wild-type and mutant RNA internal loops from the SL-1 domain of the HIV-1 packaging signal. Journal of Molecular Biology. 322: 543-57. PMID 12225748 DOI: 10.1016/S0022-2836(02)00776-3 |
0.502 |
|
| 2002 |
Gallego J, Varani G. The hepatitis C virus internal ribosome-entry site: a new target for antiviral research. Biochemical Society Transactions. 30: 140-5. PMID 12023841 DOI: 10.1042/Bst0300140 |
0.343 |
|
| 2002 |
Collier AJ, Gallego J, Klinck R, Cole PT, Harris SJ, Harrison GP, Aboul-Ela F, Varani G, Walker S. A conserved RNA structure within the HCV IRES eIF3-binding site. Nature Structural Biology. 9: 375-80. PMID 11927954 DOI: 10.1038/Nsb785 |
0.414 |
|
| 2002 |
Varani G, Allain FH. How a rotavirus hijacks the human protein synthesis machinery. Nature Structural Biology. 9: 158-60. PMID 11875511 DOI: 10.1038/Nsb0302-158 |
0.348 |
|
| 2002 |
Gallego J, Klinck R, Collier A, Harrison G, Harris S, Cole PT, Aboul-Ela F, Varani G, Walker S. Structure of a hepatitis C virus IRES RNA motif recognized by translation initiation factor 3 Biochemical Society Transactions. 30. DOI: 10.1042/Bst030A018A |
0.443 |
|
| 2001 |
Gallego J, Varani G. Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges. Accounts of Chemical Research. 34: 836-43. PMID 11601968 DOI: 10.1021/Ar000118K |
0.521 |
|
| 2001 |
Allen M, Varani L, Varani G. Nuclear magnetic resonance methods to study structure and dynamics of RNA-protein complexes. Methods in Enzymology. 339: 357-76. PMID 11462821 DOI: 10.1016/S0076-6879(01)39322-9 |
0.45 |
|
| 2001 |
Leulliot N, Varani G. Current topics in RNA-protein recognition: control of specificity and biological function through induced fit and conformational capture. Biochemistry. 40: 7947-56. PMID 11434763 DOI: 10.1021/Bi010680Y |
0.478 |
|
| 2001 |
Varani G. Delivering messages from the 3' end. Proceedings of the National Academy of Sciences of the United States of America. 98: 4288-9. PMID 11296278 DOI: 10.1073/Pnas.091108098 |
0.557 |
|
| 2001 |
Pérez-Cañadillas JM, Varani G. Recent advances in RNA-protein recognition. Current Opinion in Structural Biology. 11: 53-8. PMID 11179892 DOI: 10.1016/S0959-440X(00)00164-0 |
0.556 |
|
| 2000 |
Varani G, McClain WH. The G x U wobble base pair. A fundamental building block of RNA structure crucial to RNA function in diverse biological systems. Embo Reports. 1: 18-23. PMID 11256617 DOI: 10.1093/Embo-Reports/Kvd001 |
0.458 |
|
| 2000 |
Bayer P, Varani L, Varani G. Nuclear magnetic resonance methods to study RNA-protein complexes. Methods in Enzymology. 317: 198-220. PMID 10829282 DOI: 10.1016/S0076-6879(00)17016-8 |
0.56 |
|
| 2000 |
Sachs AB, Varani G. Eukaryotic translation initiation: there are (at least) two sides to every story. Nature Structural Biology. 7: 356-61. PMID 10802729 DOI: 10.1038/75120 |
0.477 |
|
| 2000 |
Yasuda M, Takamatsu J, D'Souza I, Crowther RA, Kawamata T, Hasegawa M, Hasegawa H, Spillantini MG, Tanimukai S, Poorkaj P, Varani L, Varani G, Iwatsubo T, Goedert M, Schellenberg DG, et al. A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto) Annals of Neurology. 47: 422-9. PMID 10762152 DOI: 10.1002/1531-8249(200004)47:4<422::Aid-Ana4>3.0.Co;2-G |
0.308 |
|
| 2000 |
Varani L, Gunderson SI, Mattaj IW, Kay LE, Neuhaus D, Varani G. The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. Nature Structural Biology. 7: 329-35. PMID 10742179 DOI: 10.1038/74101 |
0.485 |
|
| 2000 |
Zeffman A, Hassard S, Varani G, Lever A. The major HIV-1 packaging signal is an extended bulged stem loop whose structure is altered on interaction with the Gag polyprotein. Journal of Molecular Biology. 297: 877-93. PMID 10736224 DOI: 10.1006/Jmbi.2000.3611 |
0.495 |
|
| 2000 |
Ramos A, Grünert S, Adams J, Micklem DR, Proctor MR, Freund S, Bycroft M, St Johnston D, Varani G. RNA recognition by a Staufen double-stranded RNA-binding domain. The Embo Journal. 19: 997-1009. PMID 10698941 DOI: 10.1093/Emboj/19.5.997 |
0.566 |
|
| 2000 |
Varani L, Spillantini MG, Goedert M, Varani G. Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics. Nucleic Acids Research. 28: 710-9. PMID 10637322 DOI: 10.1093/Nar/28.3.710 |
0.548 |
|
| 2000 |
Lever A, Dorman N, Chadwick D, Hassard S, Zeffman A, Varani G. O7 Structural solution of the HIV-1 packaging signal and use of RNA transcripts containing the signal as potential antiviral molecules Hiv Medicine. 1: 167-168. DOI: 10.1046/J.1468-1293.2000.00024-13.X |
0.41 |
|
| 1999 |
Ramos A, Bayer P, Varani G. Determination of the structure of the RNA complex of a double-stranded RNA-binding domain from Drosophila Staufen protein. Biopolymers. 52: 181-96. PMID 11295750 DOI: 10.1002/1097-0282(1999)52:4<181::Aid-Bip1003>3.0.Co;2-5 |
0.587 |
|
| 1999 |
Richter C, Griesinger C, Felli I, Cole PT, Varani G, Schwalbe H. Determination of sugar conformation in large RNA oligonucleotides from analysis of dipole-dipole cross correlated relaxation by solution NMR spectroscopy. Journal of Biomolecular Nmr. 15: 241-50. PMID 10677827 DOI: 10.1023/A:1008319130714 |
0.428 |
|
| 1999 |
Mittermaier A, Varani L, Muhandiram DR, Kay LE, Varani G. Changes in side-chain and backbone dynamics identify determinants of specificity in RNA recognition by human U1A protein. Journal of Molecular Biology. 294: 967-79. PMID 10588900 DOI: 10.1006/Jmbi.1999.3311 |
0.562 |
|
| 1999 |
Chang KY, Varani G, Bhattacharya S, Choi H, McClain WH. Correlation of deformability at a tRNA recognition site and aminoacylation specificity. Proceedings of the National Academy of Sciences of the United States of America. 96: 11764-9. PMID 10518524 DOI: 10.1073/Pnas.96.21.11764 |
0.417 |
|
| 1999 |
Bayer P, Varani L, Varani G. Refinement of the structure of protein-RNA complexes by residual dipolar coupling analysis. Journal of Biomolecular Nmr. 14: 149-55. PMID 10427742 DOI: 10.1023/A:1008360331296 |
0.55 |
|
| 1999 |
Varani L, Hasegawa M, Spillantini MG, Smith MJ, Murrell JR, Ghetti B, Klug A, Goedert M, Varani G. Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17. Proceedings of the National Academy of Sciences of the United States of America. 96: 8229-34. PMID 10393977 DOI: 10.1073/Pnas.96.14.8229 |
0.355 |
|
| 1999 |
Afshar M, Prescott CD, Varani G. Structure-based and combinatorial search for new RNA-binding drugs. Current Opinion in Biotechnology. 10: 59-63. PMID 10047503 DOI: 10.1016/S0958-1669(99)80011-1 |
0.509 |
|
| 1998 |
Varani G, Nagai K. RNA recognition by RNP proteins during RNA processing. Annual Review of Biophysics and Biomolecular Structure. 27: 407-45. PMID 9646873 DOI: 10.1146/Annurev.Biophys.27.1.407 |
0.545 |
|
| 1998 |
Howe PW, Allain FH, Varani G, Neuhaus D. Determination of the NMR structure of the complex between U1A protein and its RNA polyadenylation inhibition element. Journal of Biomolecular Nmr. 11: 59-84. PMID 9566313 DOI: 10.1023/A:1008297502874 |
0.494 |
|
| 1998 |
Ramos A, Varani G. A new method to detect long-range protein-RNA contacts: NMR detection of electron-proton relaxation induced by nitroxide spin-labeled RNA [9] Journal of the American Chemical Society. 120: 10992-10993. DOI: 10.1021/Ja982496E |
0.446 |
|
| 1998 |
Aboul-ela F, Varani G. Recognition of HIV-1 TAR RNA by Tat protein and Tat-derived peptides Journal of Molecular Structure: Theochem. 423: 29-39. DOI: 10.1016/S0166-1280(96)04995-0 |
0.538 |
|
| 1997 |
Varani G. RNA-protein recognition during RNA maturation and development Nucleic Acids Symposium Series. 36-38. PMID 9478199 |
0.411 |
|
| 1997 |
Allain FH, Howe PW, Neuhaus D, Varani G. Structural basis of the RNA-binding specificity of human U1A protein. The Embo Journal. 16: 5764-72. PMID 9312034 DOI: 10.1093/Emboj/16.18.5764 |
0.572 |
|
| 1997 |
Varani G. A cap for all occasions. Structure (London, England : 1993). 5: 855-8. PMID 9261078 DOI: 10.1016/S0969-2126(97)00239-6 |
0.318 |
|
| 1997 |
Ramos A, Gubser CC, Varani G. Recent solution structures of RNA and its complexes with drugs, peptides and proteins. Current Opinion in Structural Biology. 7: 317-23. PMID 9204272 DOI: 10.1016/S0959-440X(97)80046-2 |
0.548 |
|
| 1997 |
Ramos A, Varani G. Structure of the acceptor stem of Escherichia coli tRNA Ala: role of the G3.U70 base pair in synthetase recognition. Nucleic Acids Research. 25: 2083-90. PMID 9153306 DOI: 10.1093/Nar/25.11.2083 |
0.359 |
|
| 1997 |
Hamy F, Felder ER, Heizmann G, Lazdins J, Aboul-ela F, Varani G, Karn J, Klimkait T. An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication. Proceedings of the National Academy of Sciences of the United States of America. 94: 3548-53. PMID 9108013 DOI: 10.1073/Pnas.94.8.3548 |
0.487 |
|
| 1997 |
Allain FH, Varani G. How accurately and precisely can RNA structure be determined by NMR? Journal of Molecular Biology. 267: 338-51. PMID 9096230 DOI: 10.1006/Jmbi.1996.0855 |
0.522 |
|
| 1997 |
Varani G. RNA - Protein Intermolecular Recognition Accounts of Chemical Research. 30: 189-195. DOI: 10.1021/Ar960035X |
0.509 |
|
| 1996 |
Aboul-ela F, Karn J, Varani G. Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge Nucleic Acids Research. 24: 3974-3981. PMID 8918800 DOI: 10.1093/Nar/24.20.3974 |
0.581 |
|
| 1996 |
Gubser CC, Varani G. Structure of the polyadenylation regulatory element of the human U1A pre-mRNA 3′-untranslated region and interaction with the U1A protein Biochemistry. 35: 2253-2267. PMID 8652566 DOI: 10.1021/Bi952319F |
0.576 |
|
| 1996 |
Avis JM, Allain FHT, Howe PWA, Varani G, Nagai K, Neuhaus D. Solution structure of the N-terminal RNP domain of U1A protein: The role of C-terminal residues in structure stability and RNA binding Journal of Molecular Biology. 257: 398-411. PMID 8609632 DOI: 10.1006/Jmbi.1996.0171 |
0.56 |
|
| 1996 |
Allain FH, Gubser CC, Howe PW, Nagai K, Neuhaus D, Varani G. Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation. Nature. 380: 646-50. PMID 8602269 DOI: 10.1038/380646A0 |
0.561 |
|
| 1996 |
Varani G, Aboul-Ela F, Allain FHT. NMR investigation of RNA structure Progress in Nuclear Magnetic Resonance Spectroscopy. 29: 51-127. DOI: 10.1016/0079-6565(96)01028-X |
0.521 |
|
| 1995 |
Allain FHT, Varani G. Divalent metal ion binding to a conserved wobble pair defining the upstream site of cleavage of group I self-splicing introns Nucleic Acids Research. 23: 341-350. PMID 7885828 DOI: 10.1093/Nar/23.3.341 |
0.412 |
|
| 1995 |
Allain FHT, Varani G. Structure of the P1 helix from group I self-splicing introns Journal of Molecular Biology. 250: 333-353. PMID 7608979 DOI: 10.1006/Jmbi.1995.0381 |
0.5 |
|
| 1995 |
Aboul-ela F, Karn J, Varani G. The Structure of the Human Immunodeficiency Virus Type-1 TAR RNA Reveals Principles of RNA Recognition by Tat Protein Journal of Molecular Biology. 253: 313-332. PMID 7563092 DOI: 10.1006/Jmbi.1995.0555 |
0.562 |
|
| 1995 |
Varani G. Exceptionally stable nucleic acid hairpins Annual Review of Biophysics and Biomolecular Structure. 24: 379-404. PMID 7545040 DOI: 10.1146/Annurev.Bb.24.060195.002115 |
0.541 |
|
| 1995 |
Varani G, Aboul-ela F, Allain F, Gubser CC. Novel three-dimensional 1H-13C-31P triple resonance experiments for sequential backbone correlations in nucleic acids Journal of Biomolecular Nmr. 5: 315-320. PMID 7540446 DOI: 10.1007/Bf00211759 |
0.308 |
|
| 1995 |
Aboul-ela F, Varani G. Novel techniques in nuclear magnetic resonance for nucleic acids Current Opinion in Biotechnology. 6: 89-95. PMID 7534507 DOI: 10.1016/0958-1669(95)80014-X |
0.445 |
|
| 1994 |
Howe PWA, Nagai K, Neuhaus D, Varani G. NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein Embo Journal. 13: 3873-3881. PMID 8070414 DOI: 10.1002/J.1460-2075.1994.Tb06698.X |
0.505 |
|
| 1994 |
Hines JV, Landry SM, Varani G, Tinoco I. Carbon-Proton Scalar Couplings in RNA: 3D Heteronuclear and 2D Isotope-Edited NMR of a 13C-Labeled Extra-stable Hairpin Journal of the American Chemical Society. 116: 5823-5831. DOI: 10.1021/Ja00092A037 |
0.489 |
|
| 1994 |
Tinoco I, Chastain M, Chen X, Cheong C, Hines J, James J, Molinaro M, Shen L, Varani G, Wimberly B. Non-Watson-Crick base pairs and RNA structure Clinical Chemistry. 40: 646-647. |
0.404 |
|
| 1993 |
Wimberly B, Varani G, Tinoco I. The conformation of loop E of eukaryotic 5S ribosomal RNA Biochemistry. 32: 1078-1087. PMID 8424938 DOI: 10.1021/Bi00055A013 |
0.644 |
|
| 1993 |
Hines JV, Varani G, Landry SM, Tinoco I. The stereospecific assignment of H5' and H5'' in RNA using the sign of two-bond carbon-proton scalar couplings Journal of the American Chemical Society. 115: 11002-11003. DOI: 10.1021/Ja00076A073 |
0.551 |
|
| 1991 |
Varani G, Tinoco I. RNA structure and NMR spectroscopy Quarterly Reviews of Biophysics. 24: 479-532. PMID 1723809 DOI: 10.1017/S0033583500003875 |
0.646 |
|
| 1991 |
Varani G, Cheong C, Tinoco I. Structure of an unusually stable RNA hairpin. Biochemistry. 30: 3280-9. PMID 1706937 DOI: 10.1021/Bi00227A016 |
0.67 |
|
| 1991 |
Varani G, Tinoco I. Carbon assignments and heteronuclear coupling constants for an RNA oligonucleotide from natural abundance carbon-13-proton correlated experiments Journal of the American Chemical Society. 113: 9349-9354. DOI: 10.1021/Ja00024A044 |
0.56 |
|
| 1991 |
Wimberly B, Varani G, Tinoco I. Structural determinants of RNA function Current Opinion in Structural Biology. 1: 405-409. DOI: 10.1016/0959-440X(91)90039-V |
0.672 |
|
| 1990 |
Cheong C, Varani G, Tinoco I. Solution structure of an unusually stable RNA hairpin, 5′GGAC(UUCG)GUCC Nature. 346: 680-682. PMID 1696688 DOI: 10.1038/346680A0 |
0.704 |
|
| 1989 |
Varani G, Wimberly B, Tinoco I. Conformation and dynamics of an RNA internal loop Biochemistry. 28: 7760-7772. PMID 2482068 DOI: 10.1021/Bi00445A036 |
0.665 |
|
| 1988 |
Baldini G, Varani G. Solvation effects and the mechanism of drug-DNA binding. Biochemical Pharmacology. 37: 1825-6. PMID 3377844 DOI: 10.1016/0006-2952(88)90465-0 |
0.522 |
|
| 1988 |
Adoul-Ela F, Varani G, Walker GT, Tinoco I. The TFIIIA recognition fragment d(GGATGGGAG)·d(CTCCCATCC) is B-form in solution Nucleic Acids Research. 16: 3559-3572. PMID 3375064 DOI: 10.1093/Nar/16.8.3559 |
0.604 |
|
| 1988 |
Varani G, Chirico G, Baldini G. Solvation thermodynamics of ethidium bromide in mixed solvents Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases. 84: 979-992. DOI: 10.1039/F19888400979 |
0.489 |
|
| 1988 |
Baldini G, Chirico G, Della Torre L, Varani G. Role of solvation on dye fluorescence Journal of Luminescence. 40: 274-275. DOI: 10.1016/0022-2313(88)90191-3 |
0.471 |
|
| 1987 |
Varani G, Della Torre L, Baldini G. Nonspecific interactions in dye binding to DNA. Influence of alcohols and amides. Biophysical Chemistry. 28: 175-81. PMID 3440119 DOI: 10.1016/0301-4622(87)80087-X |
0.547 |
|
| 1987 |
Varani G, Baldini G, Manfredi M. Fluorescence of ethidium bromide in alcohol-water solutions Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases. 83: 1609-1620. DOI: 10.1039/F19878301609 |
0.518 |
|
| 1986 |
Baldini G, Varani G. The role of the solvent on the binding of ethidium bromide to DNA in alcohol-water mixtures. Biopolymers. 25: 2187-208. PMID 3790706 DOI: 10.1002/Bip.360251111 |
0.524 |
|
| 1985 |
Baldini G, Fu-Hua H, Varani G, Cordone L, Fornili SL, Onori G. DNA melting induced by alcohols: Role of the solvent properties Il Nuovo Cimento D. 6: 618-630. DOI: 10.1007/Bf02450597 |
0.484 |
|
| 1985 |
Baldini G, Fornoni M, Varani G. Pseudoelectrostatic effects in the thermodynamics of dye binding to DNA Il Nuovo Cimento D. 6: 593-608. DOI: 10.1007/BF02450595 |
0.47 |
|
| 1983 |
Baldini G, Succi M, Varani G. On the binding of ligands to macromolecules: an accurate procedure Il Nuovo Cimento D. 2: 1065-1074. DOI: 10.1007/Bf02457141 |
0.518 |
|
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