| Year |
Citation |
Score |
| 2024 |
Kim GR, Kim S, Kim YO, Han X, Nagel J, Kim J, Song DI, Müller CE, Yoon MH, Jin MS, Kim YC. Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy. Journal of Medicinal Chemistry. PMID 39102524 DOI: 10.1021/acs.jmedchem.4c01214 |
0.361 |
|
| 2023 |
Ko B, Jang Y, Kwak SH, You H, Kim JH, Lee JE, Park HD, Kim SK, Goddard WA, Han JH, Kim YC. Discovery of 3-Phenyl Indazole-Based Novel Chemokine-like Receptor 1 Antagonists for the Treatment of Psoriasis. Journal of Medicinal Chemistry. PMID 37883692 DOI: 10.1021/acs.jmedchem.3c01011 |
0.573 |
|
| 2023 |
Jung JH, Jang IH, Yang MY, Kim S, Kim SK, Goddard WA, Kim YC. Discovery and Binding Mechanism of Pyrazoloisoquinoline-Based Novel β-Arrestin Inverse Agonists of the Kappa-Opioid Receptor. Journal of Medicinal Chemistry. PMID 36987735 DOI: 10.1021/acs.jmedchem.3c00064 |
0.584 |
|
| 2022 |
Jung JH, Jang IH, Kim YO, Kim S, Yoon MH, Kim YC. Discovery of pyrazole-1-carboxamide derivatives as novel Gi-biased μ-opioid receptor agonists. Drug Development Research. PMID 36124859 DOI: 10.1002/ddr.21980 |
0.374 |
|
| 2022 |
Kim YC, Karton Y, Ji XD, Melman N, Linden J, Jacobson KA. Acyl-Hydrazide Derivatives of a Xanthine Carboxylic Congener (XCC) as Selective Antagonists at Human A Adenosine Receptors. Drug Development Research. 47: 178-188. PMID 35790094 DOI: 10.1002/(sici)1098-2299(199908)47:4<178::aid-ddr4>3.0.co;2-l |
0.584 |
|
| 2022 |
Bae J, Mook Kang K, Kim YC. Discovery of 5-methyl-1H-benzo[d]imidazole derivatives as novel P2X3 Receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 72: 128820. PMID 35644300 DOI: 10.1016/j.bmcl.2022.128820 |
0.368 |
|
| 2022 |
Vlachodimou A, de Vries H, Pasoli M, Goudswaard M, Kim SA, Kim YC, Scortichini M, Marshall M, Linden J, Heitman LH, Jacobson KA, IJzerman AP. Kinetic profiling and functional characterization of 8-phenylxanthine derivatives as A adenosine receptor antagonists. Biochemical Pharmacology. 200: 115027. PMID 35395239 DOI: 10.1016/j.bcp.2022.115027 |
0.486 |
|
| 2022 |
Bae J, Kim YO, Han X, Yoon MH, Kim WM, Kim YC. Synthesis and Structure-Activity Relationship Studies of Benzimidazole-4,7-dione-Based P2X3 Receptor Antagonists as Novel Anti-Nociceptive Agents. Molecules (Basel, Switzerland). 27. PMID 35209126 DOI: 10.3390/molecules27041337 |
0.343 |
|
| 2020 |
Jeong P, Moon Y, Lee JH, Lee SD, Park J, Lee J, Kim J, Lee HJ, Kim NY, Choi J, Heo JD, Shin JE, Park HW, Kim YG, Han SY, ... Kim YC, et al. Discovery of orally active indirubin-3'-oxime derivatives as potent type 1 FLT3 inhibitors for acute myeloid leukemia. European Journal of Medicinal Chemistry. 195: 112205. PMID 32272419 DOI: 10.1016/J.Ejmech.2020.112205 |
0.394 |
|
| 2019 |
Jeong P, Kim SK, Li Q, Oh SJ, Son S, Chen G, Tan H, Kim S, Park JH, Park KD, Kim YO, Yoon MH, Kim YC, Goddard W. Discovery of Novel Biased Opioid Receptor Ligands through Structure-Based Pharmacophore Virtual Screening and Experiment. Chemmedchem. PMID 31359587 DOI: 10.1002/Cmdc.201900418 |
0.581 |
|
| 2019 |
Yoon KB, Lee HJ, Chung HJ, Lee J, Choi J, Heo JD, Kim YC, Han SY. Discovery of LDD-1075 as a potent FLT3 inhibitor. Oncology Letters. 17: 4735-4741. PMID 30944659 DOI: 10.3892/Ol.2019.10096 |
0.35 |
|
| 2018 |
Ndolo KM, An SJ, Park KR, Lee HJ, Yoon KB, Kim YC, Han SY. Discovery of an Indirubin Derivative as a Novel c-Met Kinase Inhibitor with Anti-Tumor Effects. Biomolecules & Therapeutics. PMID 30060294 DOI: 10.4062/Biomolther.2018.091 |
0.329 |
|
| 2018 |
Yoon JS, Jarhad DB, Kim G, Nayak A, Zhao LX, Yu J, Kim HR, Lee JY, Mulamoottil VA, Chandra G, Byun WS, Lee SK, Kim YC, Jeong LS. Design, synthesis and anticancer activity of fluorocyclopentenyl-purines and - pyrimidines. European Journal of Medicinal Chemistry. 155: 406-417. PMID 29906687 DOI: 10.1016/j.ejmech.2018.06.003 |
0.668 |
|
| 2018 |
Kwak SH, Shin S, Lee JH, Shim JK, Kim M, Lee SD, Lee A, Bae J, Park JH, Abdelrahman A, Müller CE, Cho SK, Kang SG, Bae MA, Yang JY, ... ... Kim YC, et al. Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells. European Journal of Medicinal Chemistry. 151: 462-481. PMID 29649742 DOI: 10.1016/J.Ejmech.2018.03.023 |
0.722 |
|
| 2018 |
Karoutzou O, Kwak SH, Lee SD, Martínez-Falguera D, Sureda FX, Vázquez S, Kim YC, Barniol-Xicota M. Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7-NMDA Receptor Antagonists. Molecules (Basel, Switzerland). 23. PMID 29361735 DOI: 10.3390/molecules23010230 |
0.302 |
|
| 2017 |
Jung YH, Kim YC, Kim YO, Lin H, Cho JH, Park JH, Lee SD, Bae J, Kang KM, Kim YG, Pae AN, Ko H, Park CS, Yoon MH. Discovery of Potent Antiallodynic Agents for Neuropathic Pain Targeting P2X3 Receptors. Acs Chemical Neuroscience. PMID 28323403 DOI: 10.1021/acschemneuro.6b00401 |
0.703 |
|
| 2017 |
Jung YH, Kim YO, Han JH, Kim YC, Yoon MH. Isobolographic Analysis of Drug Combinations With Intrathecal BRL52537 (κ-Opioid Agonist), Pregabalin (Calcium Channel Modulator), AF 353 (P2X3 Receptor Antagonist), and A804598 (P2X7 Receptor Antagonist) in Neuropathic Rats. Anesthesia and Analgesia. PMID 28277328 DOI: 10.1213/ANE.0000000000001883 |
0.31 |
|
| 2017 |
Barniol-Xicota M, Kwak SH, Lee SD, Caseley E, Valverde E, Jiang LH, Kim YC, Vázquez S. Escape from adamantane: Scaffold optimization of novel P2X7 antagonists featuring complex polycycles. Bioorganic & Medicinal Chemistry Letters. PMID 28126517 DOI: 10.1016/J.Bmcl.2017.01.039 |
0.325 |
|
| 2016 |
Kwak SH, Kang JA, Kim M, Lee SD, Park JH, Park SG, Ko H, Kim YC. Discovery and structure-activity relationship studies of quinolinone derivatives as potent IL-2 suppressive agents. Bioorganic & Medicinal Chemistry. PMID 27647370 DOI: 10.1016/j.bmc.2016.08.051 |
0.654 |
|
| 2016 |
Yoon YK, Kim JH, Kim JH, Kwon JY, Kim YC, Kim YJ, Park ZY. Pyrazolodiazepine derivatives with agonist activity toward Drosophila RYamide receptor. Bioorganic & Medicinal Chemistry Letters. PMID 27597247 DOI: 10.1016/J.Bmcl.2016.08.039 |
0.39 |
|
| 2016 |
Lee SM, Yoon KB, Lee HJ, Kim J, Chung YK, Cho WJ, Mukai C, Choi S, Kang KW, Han SY, Ko H, Kim YC. The discovery of 2,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 2 (JAK2) inhibitors versus JAK1 and JAK3. Bioorganic & Medicinal Chemistry. PMID 27555284 DOI: 10.1016/J.Bmc.2016.08.008 |
0.676 |
|
| 2016 |
Park JH, Williams DR, Lee JH, Lee SD, Lee JH, Ko H, Lee GE, Kim S, Lee JM, Abdelrahman A, Müller CE, Jung DW, Kim YC. Potent Suppressive Effects of 1-Piperidinylimidazole Based Novel P2X7 Receptor Antagonists on Cancer Cell Migration and Invasion. Journal of Medicinal Chemistry. PMID 27427902 DOI: 10.1021/Acs.Jmedchem.5B01690 |
0.721 |
|
| 2016 |
Kim BK, Ko H, Jeon ES, Ju ES, Jeong LS, Kim YC. 2,3,4-Trihydroxybenzyl-hydrazide analogues as novel potent coxsackievirus B3 3C protease inhibitors. European Journal of Medicinal Chemistry. 120: 202-216. PMID 27191615 DOI: 10.1016/j.ejmech.2016.03.085 |
0.667 |
|
| 2016 |
Kim JH, Kim SK, Lee JH, Kim YJ, Goddard WA, Kim YC. Homology modeling and molecular docking studies of Drosophila and Aedes sex peptide receptors. Journal of Molecular Graphics & Modelling. 66: 115-122. PMID 27060892 DOI: 10.1016/J.Jmgm.2016.03.014 |
0.575 |
|
| 2015 |
Park JH, Lee GE, Lee SD, Ko H, Kim YC. Structure-activity relationship studies of pyrimidine-2,4-dione derivatives as potent P2X7 receptor antagonists. European Journal of Medicinal Chemistry. 106: 180-193. PMID 26547056 DOI: 10.1016/j.ejmech.2015.10.036 |
0.762 |
|
| 2015 |
Kwak SH, Lee WG, Lee YJ, Lee SD, Kim YC, Ko H. Discovery of novel purine-based heterocyclic P2X7 receptor antagonists. Bioorganic Chemistry. 61: 58-65. PMID 26123174 DOI: 10.1016/j.bioorg.2015.06.003 |
0.698 |
|
| 2015 |
Kim JH, Jeong PH, Lee JY, Lee JH, Kim YJ, Kim YC. Discovery and structure-activity relationships of pyrazolodiazepine derivatives as the first small molecule agonists of the Drosophila sex peptide receptor. Bioorganic & Medicinal Chemistry. 23: 1808-16. PMID 25797164 DOI: 10.1016/J.Bmc.2015.02.035 |
0.353 |
|
| 2015 |
You H, Yoon HE, Jeong PH, Ko H, Yoon JH, Kim YC. Pheophorbide-a conjugates with cancer-targeting moieties for targeted photodynamic cancer therapy. Bioorganic & Medicinal Chemistry. 23: 1453-62. PMID 25753328 DOI: 10.1016/j.bmc.2015.02.014 |
0.68 |
|
| 2015 |
Park JH, Lee GE, Lee SD, Hien TT, Kim S, Yang JW, Cho JH, Ko H, Lim SC, Kim YG, Kang KW, Kim YC. Discovery of novel 2,5-dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62. Journal of Medicinal Chemistry. 58: 2114-34. PMID 25597334 DOI: 10.1021/jm500324g |
0.72 |
|
| 2015 |
Kwak SH, Kim MJ, Lee SD, You H, Kim YC, Ko H. Solid-phase synthesis of quinolinone library. Acs Combinatorial Science. 17: 60-9. PMID 25437883 DOI: 10.1021/co5001585 |
0.715 |
|
| 2015 |
Moon S, Bae JY, Son HK, Lee DY, Park G, You H, Ko H, Kim YC, Kim J. RUNX3 confers sensitivity to pheophorbide a-photodynamic therapy in human oral squamous cell carcinoma cell lines. Lasers in Medical Science. 30: 499-507. PMID 23700080 DOI: 10.1007/s10103-013-1350-1 |
0.614 |
|
| 2013 |
Cho JH, Jung KY, Jung Y, Kim MH, Ko H, Park CS, Kim YC. Design and synthesis of potent and selective P2X₃ receptor antagonists derived from PPADS as potential pain modulators. European Journal of Medicinal Chemistry. 70: 811-30. PMID 24246730 DOI: 10.1016/j.ejmech.2013.10.026 |
0.744 |
|
| 2013 |
Jung KY, Cho JH, Lee JS, Kim HJ, Kim YC. Synthesis and structure-activity relationships of carboxylic acid derivatives of pyridoxal as P2X receptor antagonists. Bioorganic & Medicinal Chemistry. 21: 2643-50. PMID 23510563 DOI: 10.1016/j.bmc.2013.01.073 |
0.414 |
|
| 2012 |
Lee WG, Lee SD, Cho JH, Jung Y, Kim JH, Hien TT, Kang KW, Ko H, Kim YC. Structure-activity relationships and optimization of 3,5-dichloropyridine derivatives as novel P2X(7) receptor antagonists. Journal of Medicinal Chemistry. 55: 3687-98. PMID 22400713 DOI: 10.1021/jm2012326 |
0.735 |
|
| 2012 |
Lee WG, Kim WS, Park SG, Kim H, Hong J, Ko H, Kim YC. Immunosuppressive effects of subglutinol derivatives. Chemmedchem. 7: 218-22. PMID 22114006 DOI: 10.1002/Cmdc.201100409 |
0.623 |
|
| 2012 |
Lee S, Lee W, Kim Y, Ko H. CorrigendumCorrigendum to “Synthesis and biological evaluation of α, β unsaturated lactones as potent immunosuppressive agents” [Bioorg. Med. Chem. Lett., 2011, 21, 5726–5729] Bioorganic & Medicinal Chemistry Letters. 22: 1287. DOI: 10.1016/J.Bmcl.2011.12.010 |
0.631 |
|
| 2011 |
You H, Yoon HE, Yoon JH, Ko H, Kim YC. Synthesis of pheophorbide-a conjugates with anticancer drugs as potential cancer diagnostic and therapeutic agents. Bioorganic & Medicinal Chemistry. 19: 5383-91. PMID 21873067 DOI: 10.1016/j.bmc.2011.07.058 |
0.623 |
|
| 2011 |
Lee SM, Lee WG, Kim YC, Kim YC, Ko H. Synthesis and biological evaluation of α,β-unsaturated lactones as potent immunosuppressive agents. Bioorganic & Medicinal Chemistry Letters. 21: 5726-9. PMID 21873054 DOI: 10.1016/j.bmcl.2011.08.020 |
0.643 |
|
| 2011 |
You H, Youn HS, Im I, Bae MH, Lee SK, Ko H, Eom SH, Kim YC. Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents. European Journal of Medicinal Chemistry. 46: 1153-64. PMID 21330015 DOI: 10.1016/j.ejmech.2011.01.034 |
0.658 |
|
| 2011 |
Lee GE, Lee WG, Lee SY, Lee CR, Park CS, Chang S, Park SG, Song MR, Kim YC. Characterization of protoberberine analogs employed as novel human P2X7 receptor antagonists. Toxicology and Applied Pharmacology. 252: 192-200. PMID 21320518 DOI: 10.1016/j.taap.2011.02.009 |
0.396 |
|
| 2010 |
Hu H, Lu W, Zhang M, Zhang X, Argall AJ, Patel S, Lee GE, Kim YC, Jacobson KA, Laties AM, Mitchell CH. Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo. Experimental Eye Research. 91: 425-32. PMID 20599962 DOI: 10.1016/J.Exer.2010.06.017 |
0.479 |
|
| 2010 |
Choi SJ, Lee JE, Jeong SY, Im I, Lee SD, Lee EJ, Lee SK, Kwon SM, Ahn SG, Yoon JH, Han SY, Kim JI, Kim YC. 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. Journal of Medicinal Chemistry. 53: 3696-706. PMID 20361800 DOI: 10.1021/jm100080z |
0.323 |
|
| 2009 |
Lee JY, Yu J, Cho WJ, Ko H, Kim YC. Synthesis and structure-activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 19: 6053-8. PMID 19800793 DOI: 10.1016/j.bmcl.2009.09.053 |
0.706 |
|
| 2009 |
Lee JY, Im I, Webb TR, McGrath D, Song MR, Kim YC. Combinatorial synthesis and biological evaluation of peptide-binding GPCR-targeted library. Bioorganic Chemistry. 37: 90-5. PMID 19467690 DOI: 10.1016/J.Bioorg.2009.04.001 |
0.434 |
|
| 2009 |
Lee GE, Lee HS, Lee SD, Kim JH, Kim WK, Kim YC. Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists Bioorganic and Medicinal Chemistry Letters. 19: 954-958. PMID 19110420 DOI: 10.1016/j.bmcl.2008.11.088 |
0.365 |
|
| 2009 |
Lee GE, Joshi BV, Chen W, Jeong LS, Moon HR, Jacobson KA, Kim YC. Corrigendum to "Synthesis and structure-activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor" [Bioorg. Med. Chem. Lett. 18 (2008) 571-575] (DOI:10.1016/j.bmcl.2007.11.077) Bioorganic and Medicinal Chemistry Letters. 19: 556. DOI: 10.1016/J.Bmcl.2008.05.108 |
0.804 |
|
| 2008 |
Lee GE, Joshi BV, Chen W, Jeong LS, Moon HR, Jacobson KA, Kim YC. Synthesis and structure-activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor. Bioorganic & Medicinal Chemistry Letters. 18: 571-5. PMID 18078749 DOI: 10.1016/J.Bmcl.2007.11.077 |
0.821 |
|
| 2007 |
Jung KY, Moon HD, Lee GE, Lim HH, Park CS, Kim YC. Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. Journal of Medicinal Chemistry. 50: 4543-7. PMID 17676725 DOI: 10.1021/Jm070114M |
0.531 |
|
| 2006 |
Lee SY, Jo S, Lee GE, Jeong LS, Kim YC, Park CS. Establishment of an assay for P2X7 receptor-mediated cell death Molecules and Cells. 22: 198-202. PMID 17085972 |
0.35 |
|
| 2006 |
Moon MJ, Lee SK, Lee JW, Song WK, Kim SW, Kim JI, Cho C, Choi SJ, Kim YC. Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities. Bioorganic & Medicinal Chemistry. 14: 237-46. PMID 16182537 DOI: 10.1016/J.Bmc.2005.08.008 |
0.385 |
|
| 2005 |
Lee JW, Moon MJ, Min HY, Chung HJ, Park EJ, Park HJ, Hong JY, Kim YC, Lee SK. Induction of apoptosis by a novel indirubin-5-nitro-3'-monoxime, a CDK inhibitor, in human lung cancer cells. Bioorganic & Medicinal Chemistry Letters. 15: 3948-52. PMID 15993584 DOI: 10.1016/J.Bmcl.2005.05.105 |
0.31 |
|
| 2005 |
Kim YC, Lee JS, Sak K, Marteau F, Mamedova L, Boeynaems JM, Jacobson KA. Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor. Biochemical Pharmacology. 70: 266-74. PMID 15913566 DOI: 10.1016/J.Bcp.2005.04.021 |
0.818 |
|
| 2004 |
Oh M, Im I, Lee YJ, Kim YH, Yoon JH, Park HG, Higashiyama S, Kim Y, Park WJ. Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors. Bioorganic & Medicinal Chemistry Letters. 14: 6071-6074. PMID 15546732 DOI: 10.1016/J.Bmcl.2004.09.082 |
0.368 |
|
| 2004 |
Im I, Webb TR, Gong YD, Kim JI, Kim YC. Solid-phase synthesis of tetrahydro-1,4-benzodiazepine-2-one derivatives as a beta-turn peptidomimetic library. Journal of Combinatorial Chemistry. 6: 207-13. PMID 15002968 DOI: 10.1021/Cc034039M |
0.3 |
|
| 2004 |
Jung KY, Kim SK, Gao ZG, Gross AS, Melman N, Jacobson KA, Kim YC. Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists. Bioorganic & Medicinal Chemistry. 12: 613-23. PMID 14738972 DOI: 10.1016/J.Bmc.2003.10.041 |
0.71 |
|
| 2003 |
Chianelli D, Kim YC, Lvovskiy D, Webb TR. Application of a novel design paradigm to generate general nonpeptide combinatorial scaffolds mimicking beta turns: synthesis of ligands for somatostatin receptors. Bioorganic & Medicinal Chemistry. 11: 5059-68. PMID 14604669 DOI: 10.1016/J.Bmc.2003.08.022 |
0.4 |
|
| 2003 |
Jeong LS, Jin DZ, Kim HO, Shin DH, Moon HR, Gunaga P, Chun MW, Kim YC, Melman N, Gao ZG, Jacobson KA. N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor. Journal of Medicinal Chemistry. 46: 3775-7. PMID 12930138 DOI: 10.1021/Jm034098E |
0.592 |
|
| 2002 |
Guo D, von Kügelgen I, Moro S, Kim YC, Jacobson KA. Evidence for the Recognition of Non-Nucleotide Antagonists Within the Transmembrane Domains of the Human P2Y(1) Receptor. Drug Development Research. 57: 173-181. PMID 23105165 DOI: 10.1002/Ddr.10145 |
0.7 |
|
| 2002 |
Yang ST, Yub Shin SY, Kim YC, Kim Y, Hahm KS, Kim JI. Conformation-dependent antibiotic activity of tritrpticin, a cathelicidin-derived antimicrobial peptide. Biochemical and Biophysical Research Communications. 296: 1044-50. PMID 12207877 DOI: 10.1016/S0006-291X(02)02048-X |
0.316 |
|
| 2001 |
Brown SG, Kim YC, Kim SA, Jacobson KA, Burnstock G, King BF. Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors. Drug Development Research. 53: 281-291. PMID 27134334 DOI: 10.1002/Ddr.1197 |
0.617 |
|
| 2001 |
Jacobson KA, Ravi RG, Nandanan E, Kim HS, Moro S, Kim YC, Lee K, Barak D, Marquez VE, Ji XD. Ribose modified nucleosides and nucleotides as ligands for purine receptors. Nucleosides, Nucleotides & Nucleic Acids. 20: 333-41. PMID 11563046 DOI: 10.1081/Ncn-100002305 |
0.757 |
|
| 2001 |
Kim YC, Brown SG, Harden TK, Boyer JL, Dubyak G, King BF, Burnstock G, Jacobson KA. Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. Journal of Medicinal Chemistry. 44: 340-9. PMID 11462975 DOI: 10.1021/jm9904203 |
0.594 |
|
| 2001 |
Jacobson KA, Moro S, Hoffmann C, Kim YC, Kim HS, Ravi RG, Harden TK, Boyer JL. Structurally related nucleotides as selective agonists and antagonists at P2Y1 receptors. Farmaco (Società Chimica Italiana : 1989). 56: 71-5. PMID 11347970 DOI: 10.1016/S0014-827X(01)01023-0 |
0.8 |
|
| 2001 |
Ji X, Kim YC, Ahern DG, Linden J, Jacobson KA. [3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors. Biochemical Pharmacology. 61: 657-63. PMID 11266650 DOI: 10.1016/S0006-2952(01)00531-7 |
0.569 |
|
| 2000 |
Hoffmann C, Heine P, Pradel G, Kim YC, Jacobson KA, Zimmermann H. Inhibition of Ecto-Apyrase and Ecto-ATPase by Pyridoxal Phosphate-Related Compounds. Drug Development Research. 51: 151-158. PMID 27134333 DOI: 10.1002/1098-2299(200011)51:3<153::Aid-Ddr3>3.0.Co;2-X |
0.757 |
|
| 2000 |
Brown SG, King BF, Kim YC, Jang SY, Burnstock G, Jacobson KA. Activity of Novel Adenine Nucleotide Derivatives as Agonists and Antagonists at Recombinant Rat P2X Receptors. Drug Development Research. 49: 253-259. PMID 22791931 DOI: 10.1002/1098-2299(200004)49:4<253::Aid-Ddr4>3.0.Co;2-1 |
0.618 |
|
| 2000 |
Jacobson KA, Kim YC, King BF. In search of selective P2 receptor ligands: interaction of dihydropyridine derivatives at recombinant rat P2X(2) receptors. Journal of the Autonomic Nervous System. 81: 152-7. PMID 10869714 DOI: 10.1016/S0165-1838(00)00128-4 |
0.633 |
|
| 2000 |
Kim YC, Ji X, Melman N, Linden J, Jacobson KA. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. Journal of Medicinal Chemistry. 43: 1165-72. PMID 10737749 DOI: 10.1021/Jm990421V |
0.616 |
|
| 2000 |
Brambilla R, Cattabeni F, Ceruti S, Barbieri D, Franceschi C, Kim YC, Jacobson KA, Klotz KN, Lohse MJ, Abbracchio MP. Activation of the A3 adenosine receptor affects cell cycle progression and cell growth. Naunyn-Schmiedeberg's Archives of Pharmacology. 361: 225-34. PMID 10731034 DOI: 10.1007/S002109900186 |
0.498 |
|
| 2000 |
Kim YC, Gallo-Rodriguez C, Jang SY, Nandanan E, Adams M, Harden TK, Boyer JL, Jacobson KA. Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists. Journal of Medicinal Chemistry. 43: 746-55. PMID 10691699 DOI: 10.1021/jm9905211 |
0.607 |
|
| 2000 |
Kim Y, Jacobson KA. Versatile Synthesis of 6-Alkyl and Aryl Substituted Pyridoxal Derivatives Synthesis. 2000: 119-122. DOI: 10.1055/S-2000-6228 |
0.453 |
|
| 1999 |
Jacobson KA, Hoffmann C, Kim YC, Camaioni E, Nandanan E, Jang SY, Guo DP, Ji XD, von Kügelgen I, Moro S, Ziganshin AU, Rychkov A, King BF, Brown SG, Wildman SS, et al. Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis. Progress in Brain Research. 120: 119-32. PMID 10550992 DOI: 10.1016/S0079-6123(08)63550-5 |
0.786 |
|
| 1999 |
Nandanan E, Camaioni E, Jang SY, Kim YC, Cristalli G, Herdewijn P, Secrist JA, Tiwari KN, Mohanram A, Harden TK, Boyer JL, Jacobson KA. Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists. Journal of Medicinal Chemistry. 42: 1625-38. PMID 10229631 DOI: 10.1021/Jm980657J |
0.75 |
|
| 1999 |
Kim Y, Karton Y, Ji X, Melman N, Linden J, Jacobson KA. Acyl-hydrazide derivatives of a xanthine carboxylic congener (XCC) as selective antagonists at human A2B adenosine receptors Drug Development Research. 47: 178-188. DOI: 10.1002/(Sici)1098-2299(199908)47:4<178::Aid-Ddr4>3.0.Co;2-L |
0.628 |
|
| 1998 |
Jacobson KA, Moro S, Kim YC, Li AH. A Adenosine Receptors: Protective vs. Damaging Effects Identified Using Novel Agonists and Antagonists. Drug Development Research. 45: 113-124. PMID 31808655 DOI: 10.1002/(Sici)1098-2299(199811/12)45:3/4<113::Aid-Ddr5>3.0.Co;2-S |
0.703 |
|
| 1998 |
Kim YC, Camaioni E, Ziganshin AU, Ji XD, King BF, Wildman SS, Rychkov A, Yoburn J, Kim H, Mohanram A, Harden TK, Boyer JL, Burnstock G, Jacobson KA. Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. Drug Development Research. 45: 52-66. PMID 22922976 DOI: 10.1002/(Sici)1098-2299(199810)45:2<52::Aid-Ddr2>3.0.Co;2-V |
0.74 |
|
| 1998 |
Kim YC, de Zwart M, Chang L, Moro S, von Frijtag Drabbe Künzel JK, Melman N, IJzerman AP, Jacobson KA. Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes. Journal of Medicinal Chemistry. 41: 2835-45. PMID 9667972 DOI: 10.1021/Jm980094B |
0.667 |
|
| 1998 |
Jacobson KA, Kim YC, Wildman SS, Mohanram A, Harden TK, Boyer JL, King BF, Burnstock G. A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors. Journal of Medicinal Chemistry. 41: 2201-6. PMID 9632352 DOI: 10.1021/Jm980183O |
0.595 |
|
| 1997 |
Jacobson KA, Park KS, Jiang JL, Kim YC, Olah ME, Stiles GL, Ji XD. Pharmacological characterization of novel A3 adenosine receptor-selective antagonists. Neuropharmacology. 36: 1157-65. PMID 9364471 DOI: 10.1016/S0028-3908(97)00104-4 |
0.586 |
|
| 1997 |
Jiang Q, Guo D, Lee BX, Van Rhee AM, Kim YC, Nicholas RA, Schachter JB, Harden TK, Jacobson KA. A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor. Molecular Pharmacology. 52: 499-507. PMID 9281613 DOI: 10.1124/Mol.52.3.499 |
0.522 |
|
| 1997 |
Cohen BE, Lee G, Jacobson KA, Kim YC, Huang Z, Sorscher EJ, Pollard HB. 8-cyclopentyl-1,3-dipropylxanthine and other xanthines differentially bind to the wild-type and delta F508 first nucleotide binding fold (NBF-1) domains of the cystic fibrosis transmembrane conductance regulator. Biochemistry. 36: 6455-61. PMID 9174362 DOI: 10.1021/bi970150v |
0.339 |
|
| 1997 |
Yao Y, Sei Y, Abbracchio MP, Jiang JL, Kim YC, Jacobson KA. Adenosine A3 receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A3 antagonists. Biochemical and Biophysical Research Communications. 232: 317-22. PMID 9125172 DOI: 10.1006/Bbrc.1997.6290 |
0.568 |
|
| 1996 |
Kim YC, Ji XD, Jacobson KA. Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype. Journal of Medicinal Chemistry. 39: 4142-8. PMID 8863790 DOI: 10.1021/Jm960482I |
0.507 |
|
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