Linda Bloom - Publications

Affiliations: 
Biochemistry and Molecular Biology University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Biochemistry, Molecular Biology, Evolution and Development Biology

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Newcomb ESP, Douma LG, Morris LA, Bloom LB. The Escherichia coli clamp loader rapidly remodels SSB on DNA to load clamps. Nucleic Acids Research. PMID 36511874 DOI: 10.1093/nar/gkac1169  0.69
2022 Weeks-Pollenz SJ, Ali Y, Morris L, Sutera VA, Dudenhausen EE, Hibnick M, Lovett ST, Bloom LB. Characterization of the Escherichia coli XPD/Rad3 iron-sulfur helicase YoaA in complex with the DNA polymerase III clamp loader subunit chi (χ). The Journal of Biological Chemistry. 102786. PMID 36509145 DOI: 10.1016/j.jbc.2022.102786  0.601
2021 Sikand A, Jaszczur M, Bloom LB, Woodgate R, Cox MM, Goodman MF. The SOS Error-Prone DNA Polymerase V Mutasome and β-Sliding Clamp Acting in Concert on Undamaged DNA and during Translesion Synthesis. Cells. 10. PMID 34062858 DOI: 10.3390/cells10051083  0.536
2021 Sutera VA, Weeks SJ, Dudenhausen EE, Baggett HBR, Shaw MC, Brand KA, Glass DJ, Bloom LB, Lovett ST. Alternative complexes formed by the Escherichia coli clamp loader accessory protein HolC (x) with replication protein HolD (ψ) and repair protein YoaA. Dna Repair. 100: 103006. PMID 33582602 DOI: 10.1016/j.dnarep.2020.103006  0.576
2020 Tondnevis F, Dudenhausen EE, Miller AM, McKenna R, Altschul SF, Bloom LB, Neuwald AF. Deep Analysis of Residue Constraints (DARC): identifying determinants of protein functional specificity. Scientific Reports. 10: 1691. PMID 32015389 DOI: 10.1038/S41598-019-55118-6  0.491
2019 Andrud K, Xing H, Gabrielsen B, Bloom L, Mahnir V, Lee S, Green BT, Lindstrom J, Kem W. Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine. Marine Drugs. 17. PMID 31671780 DOI: 10.3390/Md17110614  0.36
2019 Sathish S, Morris L, Bloom L. Expression and Characterization of YoaA, a Putative Helicase in Bacteria, Involved in Repairing Blocks to DNA Replication Uf Journal of Undergraduate Research. 20. DOI: 10.32473/UFJUR.V20I3.106284  0.565
2017 Douma LG, Yu KK, England JK, Levitus M, Bloom LB. Mechanism of opening a sliding clamp. Nucleic Acids Research. 45: 10178-10189. PMID 28973453 DOI: 10.1093/Nar/Gkx665  0.539
2017 Purohit A, England JK, Douma LG, Tondnevis F, Bloom LB, Levitus M. Electrostatic Interactions at the Dimer Interface Stabilize the E. coli β Sliding Clamp. Biophysical Journal. 113: 794-804. PMID 28834716 DOI: 10.1016/J.Bpj.2017.06.057  0.38
2016 Tondnevis F, Weiss TM, Matsui T, Bloom LB, Mckenna R. Solution Structure of an "open" E. coli Pol III Clamp Loader Sliding Clamp Complex. Journal of Structural Biology. PMID 26968362 DOI: 10.1016/J.Jsb.2016.03.003  0.418
2015 Marzahn MR, Hayner JN, Meyer JA, Bloom LB. Kinetic analysis of PCNA clamp binding and release in the clamp loading reaction catalyzed by Saccharomyces cerevisiae replication factor C. Biochimica Et Biophysica Acta. 1854: 31-8. PMID 25450506 DOI: 10.1016/J.Bbapap.2014.09.019  0.853
2015 Tondnevis F, Gillilan RE, Bloom LB, McKenna R. Solution study of the Escherichia coli DNA polymerase III clamp loader reveals the location of the dynamic ψχ heterodimer Structural Dynamics. 2. DOI: 10.1063/1.4927407  0.426
2014 Hayner JN, Douma LG, Bloom LB. The interplay of primer-template DNA phosphorylation status and single-stranded DNA binding proteins in directing clamp loaders to the appropriate polarity of DNA. Nucleic Acids Research. 42: 10655-67. PMID 25159615 DOI: 10.1093/nar/gku774  0.864
2014 Broxson C, Hayner JN, Beckett J, Bloom LB, Tornaletti S. Human AP endonuclease inefficiently removes abasic sites within G4 structures compared to duplex DNA. Nucleic Acids Research. 42: 7708-19. PMID 24848015 DOI: 10.1093/nar/gku417  0.849
2014 Marzahn MR, Hayner JN, Finkelstein J, O'Donnell M, Bloom LB. The ATP sites of AAA+ clamp loaders work together as a switch to assemble clamps on DNA. The Journal of Biological Chemistry. 289: 5537-48. PMID 24436332 DOI: 10.1074/Jbc.M113.541466  0.845
2014 Binder JK, Ranjit S, Chakraborty M, Kanno D, Douma L, Bloom L, Levitus M. Single Molecule Studies of DNA Replication Processivity Clamps Biophysical Journal. 106: 229a. DOI: 10.1016/J.Bpj.2013.11.1342  0.556
2013 Chiraniya A, Finkelstein J, O'Donnell M, Bloom LB. A novel function for the conserved glutamate residue in the walker B motif of replication factor C. Genes. 4: 134-51. PMID 23946885 DOI: 10.3390/Genes4020134  0.782
2013 Hayner JN, Bloom LB. The β sliding clamp closes around DNA prior to release by the Escherichia coli clamp loader γ complex. The Journal of Biological Chemistry. 288: 1162-70. PMID 23161545 DOI: 10.1074/jbc.M112.406231  0.814
2012 Bloom LB, Hayner JN. Sliding clamps: an open and shut case? Current Biology : Cb. 22: R157-60. PMID 22401895 DOI: 10.1016/j.cub.2012.01.029  0.831
2012 Thompson JA, Marzahn MR, O'Donnell M, Bloom LB. Replication factor C is a more effective proliferating cell nuclear antigen (PCNA) opener than the checkpoint clamp loader, Rad24-RFC. The Journal of Biological Chemistry. 287: 2203-9. PMID 22115746 DOI: 10.1074/Jbc.C111.318899  0.638
2012 Ranjit S, Douma L, Bloom LB, Levitus M. The Stability and Dynamics of E-Coli Beta-Clamp by Single Molecule and Fluorescence Correlation Spectroscopy Biophysical Journal. 102: 179a. DOI: 10.1016/J.Bpj.2011.11.973  0.385
2011 Paschall CO, Thompson JA, Marzahn MR, Chiraniya A, Hayner JN, O'Donnell M, Robbins AH, McKenna R, Bloom LB. The Escherichia coli clamp loader can actively pry open the β-sliding clamp. The Journal of Biological Chemistry. 286: 42704-14. PMID 21971175 DOI: 10.1074/Jbc.M111.268169  0.754
2009 Thompson JA, Paschall CO, O'Donnell M, Bloom LB. A slow ATP-induced conformational change limits the rate of DNA binding but not the rate of beta clamp binding by the escherichia coli gamma complex clamp loader. The Journal of Biological Chemistry. 284: 32147-57. PMID 19759003 DOI: 10.1074/jbc.M109.045997  0.538
2009 Anderson SG, Thompson JA, Paschall CO, O'Donnell M, Bloom LB. Temporal correlation of DNA binding, ATP hydrolysis, and clamp release in the clamp loading reaction catalyzed by the Escherichia coli gamma complex. Biochemistry. 48: 8516-27. PMID 19663416 DOI: 10.1021/bi900912a  0.605
2009 Bloom LB. Loading clamps for DNA replication and repair. Dna Repair. 8: 570-8. PMID 19213612 DOI: 10.1016/j.dnarep.2008.12.014  0.643
2009 Bloom LB. DNA replication, recombination, and repair Bioinformatics For Systems Biology. 67-87. DOI: 10.1007/978-1-59745-440-7_4  0.549
2007 Balusu R, Jaiswal AS, Armas ML, Kundu CN, Bloom LB, Narayan S. Structure/function analysis of the interaction of adenomatous polyposis coli with DNA polymerase beta and its implications for base excision repair. Biochemistry. 46: 13961-74. PMID 17999539 DOI: 10.1021/Bi701632E  0.37
2007 Maher RL, Bloom LB. Pre-steady-state kinetic characterization of the AP endonuclease activity of human AP endonuclease 1. The Journal of Biological Chemistry. 282: 30577-85. PMID 17724035 DOI: 10.1074/Jbc.M704341200  0.803
2007 Anderson SG, Williams CR, O'donnell M, Bloom LB. A function for the psi subunit in loading the Escherichia coli DNA polymerase sliding clamp. The Journal of Biological Chemistry. 282: 7035-45. PMID 17210572 DOI: 10.1074/jbc.M610136200  0.602
2007 Maher RL, Vallur AC, Feller JA, Bloom LB. Slow base excision by human alkyladenine DNA glycosylase limits the rate of formation of AP sites and AP endonuclease 1 does not stimulate base excision. Dna Repair. 6: 71-81. PMID 17018265 DOI: 10.1016/J.Dnarep.2006.09.001  0.816
2006 Bloom LB. Dynamics of loading the Escherichia coli DNA polymerase processivity clamp. Critical Reviews in Biochemistry and Molecular Biology. 41: 179-208. PMID 16760017 DOI: 10.1080/10409230600648751  0.484
2006 Hariharan C, Bloom LB, Helquist SA, Kool ET, Reha-Krantz LJ. Dynamics of nucleotide incorporation: snapshots revealed by 2-aminopurine fluorescence studies. Biochemistry. 45: 2836-44. PMID 16503638 DOI: 10.1021/Bi051644S  0.493
2006 Aksyonov SA, Bittner M, Bloom LB, Reha-Krantz LJ, Gould IR, Hayes MA, Kiernan UA, Niederkofler EE, Pizziconi V, Rivera RS, Williams DJ, Williams P. Multiplexed DNA sequencing-by-synthesis. Analytical Biochemistry. 348: 127-38. PMID 16289447 DOI: 10.1016/J.Ab.2005.10.001  0.502
2005 Vallur AC, Maher RL, Bloom LB. The efficiency of hypoxanthine excision by alkyladenine DNA glycosylase is altered by changes in nearest neighbor bases. Dna Repair. 4: 1088-98. PMID 15990363 DOI: 10.1016/J.Dnarep.2005.05.008  0.828
2004 Shaw RW, Feller JA, Bloom LB. Contribution of a conserved phenylalanine residue to the activity of Escherichia coli uracil DNA glycosylase. Dna Repair. 3: 1273-83. PMID 15336623 DOI: 10.1016/J.Dnarep.2004.05.003  0.817
2004 Bertram JG, Bloom LB, O'Donnell M, Goodman MF. Increased dNTP binding affinity reveals a nonprocessive role for Escherichia coli beta clamp with DNA polymerase IV. The Journal of Biological Chemistry. 279: 33047-50. PMID 15210708 DOI: 10.1074/jbc.C400265200  0.631
2004 Snyder AK, Williams CR, Johnson A, O'Donnell M, Bloom LB. Mechanism of loading the Escherichia coli DNA polymerase III sliding clamp: II. Uncoupling the beta and DNA binding activities of the gamma complex. The Journal of Biological Chemistry. 279: 4386-93. PMID 14610068 DOI: 10.1074/jbc.M310430200  0.57
2004 Williams CR, Snyder AK, Kuzmic P, O'Donnell M, Bloom LB. Mechanism of loading the Escherichia coli DNA polymerase III sliding clamp: I. Two distinct activities for individual ATP sites in the gamma complex. The Journal of Biological Chemistry. 279: 4376-85. PMID 14610067 DOI: 10.1074/jbc.M310429200  0.584
2003 Ason B, Handayani R, Williams CR, Bertram JG, Hingorani MM, O'Donnell M, Goodman MF, Bloom LB. Mechanism of loading the Escherichia coli DNA polymerase III beta sliding clamp on DNA. Bona fide primer/templates preferentially trigger the gamma complex to hydrolyze ATP and load the clamp. The Journal of Biological Chemistry. 278: 10033-40. PMID 12519754 DOI: 10.1074/Jbc.M211741200  0.64
2002 Jaiswal AS, Bloom LB, Narayan S. Long-patch base excision repair of apurinic/apyrimidinic site DNA is decreased in mouse embryonic fibroblast cell lines treated with plumbagin: involvement of cyclin-dependent kinase inhibitor p21Waf-1/Cip-1. Oncogene. 21: 5912-22. PMID 12185591 DOI: 10.1038/Sj.Onc.1205789  0.468
2002 Vallur AC, Feller JA, Abner CW, Tran RK, Bloom LB. Effects of hydrogen bonding within a damaged base pair on the activity of wild type and DNA-intercalating mutants of human alkyladenine DNA glycosylase. The Journal of Biological Chemistry. 277: 31673-8. PMID 12077143 DOI: 10.1074/Jbc.M204475200  0.809
2001 Abner CW, Lau AY, Ellenberger T, Bloom LB. Base excision and DNA binding activities of human alkyladenine DNA glycosylase are sensitive to the base paired with a lesion. The Journal of Biological Chemistry. 276: 13379-87. PMID 11278716 DOI: 10.1074/Jbc.M010641200  0.856
2000 Bertram JG, Bloom LB, Hingorani MM, Beechem JM, O'Donnell M, Goodman MF. Molecular mechanism and energetics of clamp assembly in Escherichia coli. The role of ATP hydrolysis when gamma complex loads beta on DNA. The Journal of Biological Chemistry. 275: 28413-20. PMID 10874049 DOI: 10.1074/Jbc.M910441199  0.535
2000 Ason B, Bertram JG, Hingorani MM, Beechem JM, O'Donnell M, Goodman MF, Bloom LB. A model for Escherichia coli DNA polymerase III holoenzyme assembly at primer/template ends. DNA triggers a change in binding specificity of the gamma complex clamp loader. The Journal of Biological Chemistry. 275: 3006-15. PMID 10644772 DOI: 10.1074/Jbc.275.4.3006  0.616
1999 Hingorani MM, Bloom LB, Goodman MF, O'Donnell M. Division of labor--sequential ATP hydrolysis drives assembly of a DNA polymerase sliding clamp around DNA. The Embo Journal. 18: 5131-44. PMID 10487764 DOI: 10.1093/Emboj/18.18.5131  0.513
1998 Bertram JG, Bloom LB, Turner J, O'Donnell M, Beechem JM, Goodman MF. Pre-steady state analysis of the assembly of wild type and mutant circular clamps of Escherichia coli DNA polymerase III onto DNA. The Journal of Biological Chemistry. 273: 24564-74. PMID 9733751 DOI: 10.1074/jbc.273.38.24564  0.484
1998 Reha-Krantz LJ, Marquez LA, Elisseeva E, Baker RP, Bloom LB, Dunford HB, Goodman MF. The proofreading pathway of bacteriophage T4 DNA polymerase. The Journal of Biological Chemistry. 273: 22969-76. PMID 9722519 DOI: 10.1074/jbc.273.36.22969  0.559
1998 Otto MR, Bloom LB, Goodman MF, Beechem JM. Stopped-flow fluorescence study of precatalytic primer strand base-unstacking transitions in the exonuclease cleft of bacteriophage T4 DNA polymerase. Biochemistry. 37: 10156-63. PMID 9665721 DOI: 10.1021/Bi9800754  0.544
1998 Beechem JM, Otto MR, Bloom LB, Eritja R, Reha-Krantz LJ, Goodman MF. Exonuclease-polymerase active site partitioning of primer-template DNA strands and equilibrium Mg2+ binding properties of bacteriophage T4 DNA polymerase. Biochemistry. 37: 10144-55. PMID 9665720 DOI: 10.1021/Bi980074B  0.525
1997 Bloom LB, Chen X, Fygenson DK, Turner J, O'Donnell M, Goodman MF. Fidelity of Escherichia coli DNA polymerase III holoenzyme. The effects of beta, gamma complex processivity proteins and epsilon proofreading exonuclease on nucleotide misincorporation efficiencies. The Journal of Biological Chemistry. 272: 27919-30. PMID 9346941 DOI: 10.1074/Jbc.272.44.27919  0.379
1996 Bloom LB, Turner J, Kelman Z, Beechem JM, O'Donnell M, Goodman MF. Dynamics of loading the beta sliding clamp of DNA polymerase III onto DNA. The Journal of Biological Chemistry. 271: 30699-708. PMID 8940047 DOI: 10.1074/Jbc.271.48.30699  0.543
1996 Sibghat-Ullah, Gallinari P, Xu YZ, Goodman MF, Bloom LB, Jiricny J, Day RS. Base analog and neighboring base effects on substrate specificity of recombinant human G:T mismatch-specific thymine DNA-glycosylase. Biochemistry. 35: 12926-32. PMID 8841138 DOI: 10.1021/bi961022u  0.41
1994 Goodman MF, Cai H, Bloom LB, Eritja R. Nucleotide insertion and primer extension at abasic template sites in different sequence contexts. Annals of the New York Academy of Sciences. 726: 132-42; discussion 1. PMID 8092671 DOI: 10.1111/j.1749-6632.1994.tb52804.x  0.303
1994 Bloom LB, Otto MR, Eritja R, Reha-Krantz LJ, Goodman MF, Beechem JM. Pre-steady-state kinetic analysis of sequence-dependent nucleotide excision by the 3'-exonuclease activity of bacteriophage T4 DNA polymerase. Biochemistry. 33: 7576-86. PMID 8011623 DOI: 10.1021/Bi00190A010  0.384
1993 Goodman MF, Creighton S, Bloom LB, Petruska J, Kunkel TA. Biochemical basis of DNA replication fidelity Critical Reviews in Biochemistry and Molecular Biology. 28: 83-126. PMID 8485987 DOI: 10.3109/10409239309086792  0.614
1993 Bloom LB, Otto MR, Beechem JM, Goodman MF. Influence of 5'-nearest neighbors on the insertion kinetics of the fluorescent nucleotide analog 2-aminopurine by Klenow fragment. Biochemistry. 32: 11247-58. PMID 8218190 DOI: 10.1021/Bi00092A039  0.351
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