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Alex J. Lange - Publications

Affiliations: 
Biochemistry, Molecular Bio, and Biophysics University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Molecular Biology, Physiology Biology
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39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Arden C, Tudhope SJ, Petrie JL, Al-Oanzi ZH, Cullen KS, Lange AJ, Towle HC, Agius L. Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes. The Biochemical Journal. 443: 111-23. PMID 22214556 DOI: 10.1042/Bj20111280  0.519
2012 Guo X, Li H, Xu H, Woo S, Dong H, Lu F, Lange AJ, Wu C. Glycolysis in the control of blood glucose homeostasis Acta Pharmaceutica Sinica B. 2: 358-367. DOI: 10.1016/J.Apsb.2012.06.002  0.511
2010 Mulukutla BC, Khan S, Lange A, Hu WS. Glucose metabolism in mammalian cell culture: new insights for tweaking vintage pathways. Trends in Biotechnology. 28: 476-84. PMID 20691487 DOI: 10.1016/J.Tibtech.2010.06.005  0.376
2010 Guo X, Xu K, Zhang J, Li H, Zhang W, Wang H, Lange AJ, Chen YE, Huo Y, Wu C. Involvement of inducible 6-phosphofructo-2-kinase in the anti-diabetic effect of peroxisome proliferator-activated receptor gamma activation in mice. The Journal of Biological Chemistry. 285: 23711-20. PMID 20498376 DOI: 10.1074/Jbc.M110.123174  0.424
2008 Arden C, Hampson LJ, Huang GC, Shaw JA, Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ, Agius L. A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells. The Biochemical Journal. 411: 41-51. PMID 18039179 DOI: 10.1042/Bj20070962  0.493
2007 Arden C, Trainer A, de la Iglesia N, Scougall KT, Gloyn AL, Lange AJ, Shaw JA, Matschinsky FM, Agius L. Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic beta-cells: evidence for cellular instability of catalytic activity. Diabetes. 56: 1773-82. PMID 17389332 DOI: 10.2337/Db06-1151  0.403
2007 Pedersen KB, Zhang P, Doumen C, Charbonnet M, Lu D, Newgard CB, Haycock JW, Lange AJ, Scott DK. The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. American Journal of Physiology. Endocrinology and Metabolism. 292: E788-801. PMID 17106062 DOI: 10.1152/Ajpendo.00510.2006  0.449
2007 Wu C, Khan SA, Peng LJ, Li H, Carmella SG, Lange AJ. Erratum: Perturbation of glucose flux in the liver by decreasing fructose-2,6-bisphosphate levels causes hepatic insulin resistance and hyperglycemia (American Journal of Physiology-Endocrinology and Metabolism (2006) 291, 54, (E536-E543)) American Journal of Physiology-Endocrinology and Metabolism. 292. DOI: 10.1152/Ajpendo.Zh1-4813-Corr.2007  0.45
2006 Wu C, Khan SA, Peng LJ, Lange AJ. Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes. Advances in Enzyme Regulation. 46: 72-88. PMID 16860376 DOI: 10.1016/J.Advenzreg.2006.01.010  0.511
2006 Wu C, Khan SA, Peng LJ, Li H, Carmella SG, Lange AJ. Perturbation of glucose flux in the liver by decreasing F26P2 levels causes hepatic insulin resistance and hyperglycemia. American Journal of Physiology. Endocrinology and Metabolism. 291: E536-43. PMID 16621898 DOI: 10.1152/Ajpendo.00126.2006  0.438
2005 Wu C, Khan SA, Lange AJ. Regulation of glycolysis-role of insulin. Experimental Gerontology. 40: 894-9. PMID 16157461 DOI: 10.1016/J.Exger.2005.08.002  0.37
2005 Niswender CM, Willis BS, Wallen A, Sweet IR, Jetton TL, Thompson BR, Wu C, Lange AJ, McKnight GS. Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A. Genesis (New York, N.Y. : 2000). 43: 109-19. PMID 16155866 DOI: 10.1002/Gene.20159  0.439
2005 Wu C, Kang JE, Peng LJ, Li H, Khan SA, Hillard CJ, Okar DA, Lange AJ. Enhancing hepatic glycolysis reduces obesity: differential effects on lipogenesis depend on site of glycolytic modulation. Cell Metabolism. 2: 131-40. PMID 16098830 DOI: 10.1016/J.Cmet.2005.07.003  0.598
2005 Wu C, Okar DA, Kang J, Lange AJ. Reduction of hepatic glucose production as a therapeutic target in the treatment of diabetes. Current Drug Targets. Immune, Endocrine and Metabolic Disorders. 5: 51-9. PMID 15777204 DOI: 10.2174/1568008053174769  0.655
2005 Marotta DE, Anand GR, Anderson TA, Miller SP, Okar DA, Levitt DG, Lange AJ. Identification and characterization of the ATP-binding site in human pancreatic glucokinase. Archives of Biochemistry and Biophysics. 436: 23-31. PMID 15752705 DOI: 10.1016/J.Abb.2005.01.018  0.435
2005 Baar RA, Dingfelder CS, Smith LA, Bernlohr DA, Wu C, Lange AJ, Parks EJ. Investigation of in vivo fatty acid metabolism in AFABP/aP2(-/-) mice. American Journal of Physiology. Endocrinology and Metabolism. 288: E187-93. PMID 15367400 DOI: 10.1152/Ajpendo.00256.2004  0.36
2004 Okar DA, Wu C, Lange AJ. Regulation of the regulatory enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Advances in Enzyme Regulation. 44: 123-54. PMID 15581487 DOI: 10.1016/J.Advenzreg.2003.11.006  0.37
2004 Massa L, Baltrusch S, Okar DA, Lange AJ, Lenzen S, Tiedge M. Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells. Diabetes. 53: 1020-9. PMID 15047617  0.399
2004 Wu C, Okar DA, Stoeckman AK, Peng LJ, Herrera AH, Herrera JE, Towle HC, Lange AJ. A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression. Endocrinology. 145: 650-8. PMID 14617577 DOI: 10.1210/En.2003-1290  0.428
2002 Choi IY, Wu C, Okar DA, Lange AJ, Gruetter R. Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice using in vivo (13)C NMR measurements of hepatic carbohydrate metabolism. European Journal of Biochemistry / Febs. 269: 4418-26. PMID 12230553 DOI: 10.1046/J.1432-1033.2002.T01-1-03125.X  0.468
2002 McFalls EO, Murad B, Liow JS, Gannon MC, Haspel HC, Lange A, Marx D, Sikora J, Ward HB. Glucose uptake and glycogen levels are increased in pig heart after repetitive ischemia. American Journal of Physiology. Heart and Circulatory Physiology. 282: H205-11. PMID 11748064 DOI: 10.1152/Ajpheart.2002.282.1.H205  0.375
2002 Wu C, Okar DA, Newgard CB, Lange AJ. Increasing fructose 2,6-bisphosphate overcomes hepatic insulin resistance of type 2 diabetes. American Journal of Physiology. Endocrinology and Metabolism. 282: E38-45. PMID 11739081 DOI: 10.1152/Ajpendo.2002.282.1.E38  0.462
2001 Baltrusch S, Lenzen S, Okar DA, Lange AJ, Tiedge M. Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner. Journal of Biological Chemistry. 276: 43915-43923. PMID 11522786 DOI: 10.1074/Jbc.M105470200  0.468
2001 Okar DA, Lange AJ, Manzano À, Navarro-Sabatè A, Riera L, Bartrons R. PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate. Trends in Biochemical Sciences. 26: 30-35. PMID 11165514 DOI: 10.1016/S0968-0004(00)01699-6  0.403
2001 Wu C, Okar DA, Newgard CB, Lange AJ. Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production. Journal of Clinical Investigation. 107: 91-98. PMID 11134184 DOI: 10.1172/Jci11103  0.509
2000 Werve GVD, Lange AJ, Newgard C, Méchin MC, Li Y, Berteloot A. New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. Febs Journal. 267: 1533-1549. PMID 10712583 DOI: 10.1046/J.1432-1327.2000.01160.X  0.44
1999 Okar DA, Lange AJ. Fructose‐2,6‐bisphosphate and control of carbohydrate metabolism in eukaryotes Biofactors. 10: 1-14. PMID 10475585 DOI: 10.1002/Biof.5520100101  0.416
1999 Miller SP, Anand GR, Karschnia EJ, Bell GI, LaPorte DC, Lange AJ. Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype. Diabetes. 48: 1645-51. PMID 10426385 DOI: 10.2337/Diabetes.48.8.1645  0.365
1999 Okar DA, Live DH, Kirby TL, Karschnia EJ, von Weymarn LB, Armitage IM, Lange AJ. The roles of Glu-327 and His-446 in the bisphosphatase reaction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase probed by NMR spectroscopic and mutational analyses of the enzyme in the transient phosphohistidine intermediate complex. Biochemistry. 38: 4471-9. PMID 10194369 DOI: 10.1021/Bi9828728  0.338
1998 Heine‐Suñer D, Díaz‐Guillén MA, Lange AJ, Córdoba SRd. Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2). Febs Journal. 254: 103-110. PMID 9652401 DOI: 10.1046/J.1432-1327.1998.2540103.X  0.312
1997 Okar DA, Felicia ND, Gui L, Lange AJ. Labeling of recombinant protein for NMR spectroscopy: global and specific labeling of the rat liver fructose 2,6-bisphosphatase domain. Protein Expression and Purification. 11: 79-85. PMID 9325142 DOI: 10.1006/Prep.1997.0770  0.355
1997 Joaquin M, Salvado C, Bellosillo B, Lange AJ, Gil J, Tauler A. Effect of growth factors on the expression of 6-phosphofructo-2- kinase/fructose-2,6-bisphosphatase in rat-1 fibroblasts Journal of Biological Chemistry. 272: 2846-2851. PMID 9006927 DOI: 10.1074/Jbc.272.5.2846  0.344
1996 Argaud D, Zhang Q, Pan W, Maitra S, Pilkis SJ, Lange AJ. Regulation of Rat Liver Glucose-6-Phosphatase Gene Expression in Different Nutritional and Hormonal States: Gene Structure and 5′-Flanking Sequence Diabetes. 45: 1563-1571. PMID 8866562 DOI: 10.2337/Diab.45.11.1563  0.434
1995 Scott P, Lange AJ, Pilkis SJ, Kruger NJ. Carbon metabolism in leaves of transgenic tobacco (Nicotiana tabacum L.) containing elevated fructose 2,6‐bisphosphate levels Plant Journal. 7: 461-469. PMID 7757117 DOI: 10.1046/J.1365-313X.1995.7030461.X  0.304
1995 Li L, Yao WZ, Lange AJ, Pilkis SJ, Dong MQ, Yin Y, Xu GJ. Expression of chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in Escherichia coli. Biochemical and Biophysical Research Communications. 209: 883-93. PMID 7733980 DOI: 10.1006/Bbrc.1995.1581  0.405
1995 Pilkis SJ, Claus TH, Kurland IJ, Lange AJ. 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase: A Metabolic Signaling Enzyme Annual Review of Biochemistry. 64: 799-835. PMID 7574501 DOI: 10.1146/Annurev.Bi.64.070195.004055  0.377
1995 el-Maghrabi MR, Lange AJ, Jiang W, Yamagata K, Stoffel M, Takeda J, Fernald AA, Le Beau MM, Bell GI, Baker L. Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency. Genomics. 27: 520-5. PMID 7558035 DOI: 10.1006/Geno.1995.1085  0.314
1994 Maitra SR, Pan W, Lange AJ, el-Maghrabi MR, Abumrad NN, Pilkis SJ. Glucose-6-phosphatase gene expression and activity are modulated in hemorrhagic shock: evidence for a new heat-sensitive activator. Biochemical and Biophysical Research Communications. 204: 716-24. PMID 7980534 DOI: 10.1006/Bbrc.1994.2518  0.469
1990 Lange AJ, Pilkis SJ. Sequence of human liver 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase Nucleic Acids Research. 18: 3652-3652. PMID 2163524 DOI: 10.1093/Nar/18.12.3652  0.331
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