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Rudi Fasan, PhD - Publications

Affiliations: 
2008- Chemistry University of Rochester, Rochester, NY 
Area:
Bioorganic Chemistry, Chemical Biology, Biocatalysis, Protein Engineering
Website:
http://chem.chem.rochester.edu/~rfgrp/index.php
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94 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Roy S, Wang Y, Zhao X, Dayananda T, Chu JM, Zhang Y, Fasan R. Stereodivergent Synthesis of Pyridyl Cyclopropanes via Enzymatic Activation of Pyridotriazoles. Journal of the American Chemical Society. PMID 39008121 DOI: 10.1021/jacs.4c06103  0.404
2024 Villada JD, Majhi J, Lehuédé V, Hendricks ME, Neufeld K, Tona V, Fasan R. Biocatalytic Strategy for the Highly Stereoselective Synthesis of Fluorinated Cyclopropanes. Angewandte Chemie (International Ed. in English). e202406779. PMID 38752612 DOI: 10.1002/anie.202406779  0.323
2024 Vargas DA, Ren X, Sengupta A, Zhu L, Roy S, Garcia-Borràs M, Houk KN, Fasan R. Biocatalytic strategy for the construction of sp-rich polycyclic compounds from directed evolution and computational modelling. Nature Chemistry. PMID 38351380 DOI: 10.1038/s41557-023-01435-3  0.34
2023 Roy S, Vargas DA, Ma P, Sengupta A, Zhu L, Houk KN, Fasan R. Stereoselective Construction of β-, γ-, and δ-Lactam Rings via Enzymatic C-H Amidation. Nature Catalysis. 7: 65-76. PMID 38584987 DOI: 10.1038/s41929-023-01068-2  0.374
2023 Fasan R, Roy S, Vargas D, Ma P, Sengupta A, Houk K. Stereoselective Construction of β-, γ-, and δ-Lactam Rings via Enzymatic C-H Amidation. Research Square. PMID 36711830 DOI: 10.21203/rs.3.rs-2429100/v1  0.38
2022 Siriboe MG, Fasan R. Engineered Myoglobin Catalysts for Asymmetric Intermolecular Cyclopropanation Reactions. Bulletin of Japan Society of Coordination Chemistry. 80: 4-13. PMID 37621732 DOI: 10.4019/bjscc.80.4  0.394
2022 Siriboe MG, Vargas DA, Fasan R. Dehaloperoxidase Catalyzed Stereoselective Synthesis of Cyclopropanol Esters. The Journal of Organic Chemistry. PMID 36542602 DOI: 10.1021/acs.joc.2c02030  0.421
2022 Ren X, Couture BM, Liu N, Lall MS, Kohrt JT, Fasan R. Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer. Journal of the American Chemical Society. PMID 36542059 DOI: 10.1021/jacs.2c10775  0.385
2022 Ren X, Chandgude AL, Carminati DM, Shen Z, Khare SD, Fasan R. Highly stereoselective and enantiodivergent synthesis of cyclopropylphosphonates with engineered carbene transferases. Chemical Science. 13: 8550-8556. PMID 35974764 DOI: 10.1039/d2sc01965e  0.413
2022 Iannuzzelli JA, Bacik JP, Moore EJ, Shen Z, Irving EM, Vargas DA, Khare SD, Ando N, Fasan R. Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization. Biochemistry. PMID 35612958 DOI: 10.1021/acs.biochem.2c00033  0.517
2022 Nam D, Tinoco A, Shen Z, Adukure RD, Sreenilayam G, Khare SD, Fasan R. Enantioselective Synthesis of α-Trifluoromethyl Amines via Biocatalytic N-H Bond Insertion with Acceptor-Acceptor Carbene Donors. Journal of the American Chemical Society. PMID 35107997 DOI: 10.1021/jacs.1c10750  0.821
2021 Ackun-Farmmer MA, Alwaseem H, Counts M, Bortz A, Giovani S, Frisch BJ, Fasan R, Benoit DSW. Nanoparticle-Mediated Delivery of Micheliolide Analogs to Eliminate Leukemic Stem Cells in the Bone Marrow. Advanced Therapeutics. 5. PMID 35097186 DOI: 10.1002/adtp.202100100  0.759
2021 Chavali SS, Mali SM, Bonn R, Saseendran A, Bennett RP, Smith HC, Fasan R, Wedekind JE. Cyclic peptides with a distinct arginine-fork motif recognize the HIV trans-activation response RNA in vitro and in cells. The Journal of Biological Chemistry. 101390. PMID 34767799 DOI: 10.1016/j.jbc.2021.101390  0.667
2021 Ren X, Fasan R. Engineered and Artificial Metalloenzymes for Selective C-H Functionalization. Current Opinion in Green and Sustainable Chemistry. 31. PMID 34395950 DOI: 10.1016/j.cogsc.2021.100494  0.329
2021 Alwaseem H, Giovani S, Crotti M, Welle K, Jordan CT, Ghaemmaghami S, Fasan R. Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. Acs Central Science. 7: 841-857. PMID 34079900 DOI: 10.1021/acscentsci.0c01624  0.807
2021 Nam D, Steck V, Potenzino RJ, Fasan R. A Diverse Library of Chiral Cyclopropane Scaffolds via Chemoenzymatic Assembly and Diversification of Cyclopropyl Ketones. Journal of the American Chemical Society. PMID 33497207 DOI: 10.1021/jacs.0c09504  0.814
2020 Steck V, Carminati DM, Johnson NR, Fasan R. Enantioselective Synthesis of Chiral Amines via Biocatalytic Carbene N-H Insertion. Acs Catalysis. 10: 10967-10977. PMID 34484852 DOI: 10.1021/acscatal.0c02794  0.838
2020 Fasan R, Carminati DM, Decaens J, Couve-Bonnaire S, Jubault P. Biocatalytic strategy for the highly stereoselective synthesis of CHF2-containing trisubstituted cyclopropanes. Angewandte Chemie (International Ed. in English). PMID 33337576 DOI: 10.1002/anie.202015895  0.345
2020 Iannuzzelli JA, Fasan R. Expanded toolbox for directing the biosynthesis of macrocyclic peptides in bacterial cells. Chemical Science. 11: 6202-6208. PMID 32953014 DOI: 10.1039/D0Sc01699C  0.429
2020 Carminati DM, Moore EJ, Fasan R. Strategies for the expression and characterization of artificial myoglobin-based carbene transferases. Methods in Enzymology. 644: 35-61. PMID 32943150 DOI: 10.1016/Bs.Mie.2020.07.007  0.703
2020 Fasan R, Ren X, Liu N, Chandgude AL. An enzymatic platform for the highy enantioselective and stereodivergent construction of cyclopropyl-δ-lactones. Angewandte Chemie (International Ed. in English). PMID 32667122 DOI: 10.1002/Anie.202007953  0.51
2020 Pineda-Knauseder AJ, Vargas DA, Fasan R. Organic solvent stability and long-term storage of myoglobin-based carbene transfer biocatalysts. Biotechnology and Applied Biochemistry. PMID 32542734 DOI: 10.1002/Bab.1972  0.362
2020 Steck V, Kolev JN, Ren X, Fasan R. Mechanism-Guided Design and Discovery of Efficient P450-Derived C-H Amination Biocatalysts. Journal of the American Chemical Society. PMID 32407077 DOI: 10.1021/Jacs.9B12859  0.819
2020 Ren X, Chandgude AL, Fasan R. Highly Stereoselective Synthesis of Fused Cyclopropane-γ-Lactams via Biocatalytic Iron-Catalyzed Intramolecular Cyclopropanation. Acs Catalysis. 10: 2308-2313. PMID 32257580 DOI: 10.1021/Acscatal.9B05383  0.444
2020 Steck V, Sreenilayam G, Fasan R. Selective Functionalization of Aliphatic Amines via Myoglobin-catalyzed Carbene N-H Insertion. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 31: 224-229. PMID 32255925 DOI: 10.1055/S-0039-1690007  0.829
2020 Owens AE, Iannuzzelli JA, Gu Y, Fasan R. MOrPH-PhD: An Integrated Phage Display Platform for the Discovery of Functional Genetically Encoded Peptide Macrocycles. Acs Central Science. 6: 368-381. PMID 32232137 DOI: 10.1021/Acscentsci.9B00927  0.797
2020 Vila MA, Steck V, Giordano SR, Carrera I, Fasan R. C-H Amination via Nitrene Transfer Catalyzed by Mononuclear Non-Heme Iron-Dependent Enzymes. Chembiochem : a European Journal of Chemical Biology. PMID 32189465 DOI: 10.1002/Cbic.201900783  0.818
2020 Steck V, Carminati DM, Johnson N, Fasan R. Enantioselective Synthesis of Chiral Amines via Biocatalytic Carbene N—H Insertion Acs Catalysis. 10967-10977. DOI: 10.1021/Acscatal.0C02794  0.804
2019 Fasan R, Jennifer Kan SB, Zhao H. A Continuing Career in Biocatalysis: Frances H. Arnold. Acs Catalysis. 9: 9775-9788. PMID 32728486 DOI: 10.1021/Acscatal.9B02737  0.469
2019 Carminati DM, Fasan R. Stereoselective Cyclopropanation of Electron-Deficient Olefins with a Cofactor Redesigned Carbene Transferase Featuring Radical Reactivity. Acs Catalysis. 9: 9683-9697. PMID 32257582 DOI: 10.1021/Acscatal.9B02272  0.433
2019 Khade RL, Chandgude AL, Fasan R, Zhang Y. Mechanistic Investigation of Biocatalytic Heme Carbenoid Si-H Insertions. Chemcatchem. 11: 3101-3108. PMID 31428208 DOI: 10.1002/Cctc.201801755  0.379
2019 Tinoco A, Wei Y, Bacik JP, Carminati DM, Moore EJ, Ando N, Zhang Y, Fasan R. Origin of high stereocontrol in olefin cyclopropanation catalyzed by an engineered carbene transferase. Acs Catalysis. 9: 1514-1524. PMID 31134138 DOI: 10.1021/Acscatal.8B04073  0.652
2019 Moore EJ, Fasan R. Effect of proximal ligand substitutions on the carbene and nitrene transferase activity of myoglobin. Tetrahedron, Asymmetry. 75: 2357-2363. PMID 31133770 DOI: 10.1016/J.Tet.2019.03.009  0.639
2019 Fasan R, Vargas D, Khade R, Zhang Y. Biocatalytic strategy for highly diastereo- and enantioselective synthesis of 2,3-dihydrobenzofuran based tricyclic scaffolds. Angewandte Chemie (International Ed. in English). PMID 31099936 DOI: 10.1002/Anie.201903455  0.519
2019 Chandgude ALL, Ren X, Fasan R. Stereodivergent Intramolecular Cyclopropanation Enabled by Engineered Carbene Transferases. Journal of the American Chemical Society. PMID 31099569 DOI: 10.1021/Jacs.9B02700  0.475
2018 Fasan R, Chandgude AL. Highly diastereo- and enantioselective synthesis of nitrile-substituted cyclopropanes via myoglobin-mediated carbene transfer catalysis. Angewandte Chemie (International Ed. in English). PMID 30300955 DOI: 10.1002/Anie.201810059  0.497
2018 Fasan R, Vargas DA, Tinoco A, Tyagi V. Myoglobin-catalyzed C-H functionalization of unprotected indoles. Angewandte Chemie (International Ed. in English). PMID 29905974 DOI: 10.1002/Anie.201804779  0.755
2018 Moore EJ, Steck V, Bajaj P, Fasan R. Chemoselective Cyclopropanation over Carbene Y-H insertion Catalyzed by an Engineered Carbene Transferase. The Journal of Organic Chemistry. PMID 29905476 DOI: 10.1021/Acs.Joc.8B00946  0.818
2017 Sreenilayam G, Moore EJ, Steck V, Fasan R. Metal Substitution Modulates the Reactivity and Extends the Reaction Scope of Myoglobin Carbene Transfer Catalysts. Advanced Synthesis & Catalysis. 359: 2076-2089. PMID 29606929 DOI: 10.1002/Adsc.201700202  0.816
2017 Sreenilayam G, Moore EJ, Steck V, Fasan R. Stereoselective olefin cyclopropanation under aerobic conditions with an artificial enzyme incorporating an iron-chlorin e6 cofactor. Acs Catalysis. 7: 7629-7633. PMID 29576911 DOI: 10.1021/Acscatal.7B02583  0.806
2017 Saab-Rincon G, Alwaseem H, Guzmán-Luna V, Olvera L, Fasan R. Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 via Consensus-Guided Mutagenesis. Chembiochem : a European Journal of Chemical Biology. PMID 29276819 DOI: 10.1002/Cbic.201700546  0.723
2017 Wei Y, Tinoco A, Steck V, Fasan R, Zhang Y. Cyclopropanations via Heme Carbenes: Basic Mechanism and Effects of Carbene Substituent, Protein Axial Ligand, and Porphyrin Substitution. Journal of the American Chemical Society. PMID 29268614 DOI: 10.1021/Jacs.7B09171  0.82
2017 Moore EJ, Zorine D, Hansen WA, Khare SD, Fasan R. Enzyme stabilization via computationally guided protein stapling. Proceedings of the National Academy of Sciences of the United States of America. PMID 29109284 DOI: 10.1073/Pnas.1708907114  0.571
2017 Alwaseem H, Frisch BJ, Fasan R. Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis. Bioorganic & Medicinal Chemistry. PMID 28826596 DOI: 10.1016/J.Bmc.2017.08.009  0.757
2017 Owens AE, de Paola I, Hansen WA, Liu YW, Khare SD, Fasan R. Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction. Journal of the American Chemical Society. PMID 28759213 DOI: 10.1021/Jacs.7B06087  0.784
2017 Brandenberg OF, Fasan R, Arnold FH. Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions. Current Opinion in Biotechnology. 47: 102-111. PMID 28711855 DOI: 10.1016/J.Copbio.2017.06.005  0.652
2017 Fasan R. Enzymatic catalysis: New functional twists for P450s. Nature Chemistry. 9: 609-611. PMID 28644479 DOI: 10.1038/Nchem.2810  0.325
2017 Owens AE, Grasso KT, Ziegler CA, Fasan R. Two-tier Screening Platform for Directed Evolution of Aminoacyl-tRNA Synthetases with Enhanced Stop Codon Suppression Efficiency. Chembiochem : a European Journal of Chemical Biology. PMID 28383180 DOI: 10.1002/Cbic.201700039  0.786
2017 Tinoco A, Steck V, Tyagi V, Fasan R. Highly diastereo- and enantioselective synthesis of trifluoromethyl-substituted cyclopropanes via myoglobin-catalyzed transfer of trifluoromethylcarbene. Journal of the American Chemical Society. PMID 28366001 DOI: 10.1021/Jacs.7B00768  0.834
2017 Bionda N, Fasan R. Ribosomal Synthesis of Thioether-Bridged Bicyclic Peptides. Methods in Molecular Biology (Clifton, N.J.). 1495: 57-76. PMID 27714610 DOI: 10.1007/978-1-4939-6451-2_5  0.416
2016 Bajaj P, Sreenilayam G, Tyagi V, Fasan R. Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity. Angewandte Chemie (International Ed. in English). PMID 27885768 DOI: 10.1002/Anie.201608680  0.807
2016 Giovani S, Alwaseem H, Fasan R. Aldehyde and Ketone Synthesis by P450-Catalyzed Oxidative Deamination of Alkyl Azides. Chemcatchem. 8: 2609-2613. PMID 27867424 DOI: 10.1002/Cctc.201600487  0.834
2016 Tyagi V, Sreenilayam G, Bajaj P, Tinoco A, Fasan R. Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle-Kirmse Reaction. Angewandte Chemie (International Ed. in English). PMID 27647732 DOI: 10.1002/Anie.201607278  0.821
2016 Tyagi V, Alwaseem H, O'Dwyer KM, Ponder J, Li QY, Jordan CT, Fasan R. Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs. Bioorganic & Medicinal Chemistry. PMID 27396927 DOI: 10.1016/J.Bmc.2016.06.028  0.798
2016 Frost JR, Wu Z, Lam YC, Owens AE, Fasan R. Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acids. Organic & Biomolecular Chemistry. PMID 27064594 DOI: 10.1039/C6Ob00192K  0.808
2016 Giovani S, Singh R, Fasan R. Efficient conversion of primary azides to aldehydes catalyzed by active site variants of myoglobin. Chemical Science (Royal Society of Chemistry : 2010). 7: 234-239. PMID 26900445 DOI: 10.1039/C5Sc02857D  0.826
2016 Tyagi V, Fasan R. Myoglobin-Catalyzed Olefination of Aldehydes. Angewandte Chemie (International Ed. in English). 55: 2512-6. PMID 26765247 DOI: 10.1002/Anie.201508817  0.746
2016 Giovani S, Alwaseem H, Fasan R. Aldehyde and Ketone Synthesis by P450-Catalyzed Oxidative Deamination of Alkyl Azides Chemcatchem. 8: 2609-2613. DOI: 10.1002/cctc.201600487  0.836
2015 Bionda N, Fasan R. Ribosomal Synthesis of Natural-Product-Like Bicyclic Peptides in Escherichia coli. Chembiochem : a European Journal of Chemical Biology. 16: 2011-6. PMID 26179106 DOI: 10.1002/Cbic.201500179  0.433
2015 Tyagi V, Bonn RB, Fasan R. Intermolecular carbene S-H insertion catalysed by engineered myoglobin-based catalysts†. Chemical Science (Royal Society of Chemistry : 2010). 6: 2488-2494. PMID 26101581 DOI: 10.1039/C5Sc00080G  0.839
2015 Singh R, Kolev JN, Sutera PA, Fasan R. Enzymatic C(sp(3))-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones. Acs Catalysis. 5: 1685-1691. PMID 25954592 DOI: 10.1021/Cs5018612  0.82
2015 Frost JR, Jacob NT, Papa LJ, Owens AE, Fasan R. Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids. Acs Chemical Biology. 10: 1805-16. PMID 25933125 DOI: 10.1021/Acschembio.5B00119  0.779
2015 Smith JM, Fasan R. Synthesis of macrocyclic organo-peptide hybrids from ribosomal polypeptide precursors via CuAAC-/hydrazide-mediated cyclization. Methods in Molecular Biology (Clifton, N.J.). 1248: 23-38. PMID 25616323 DOI: 10.1007/978-1-4939-2020-4_2  0.576
2015 Sreenilayam G, Fasan R. Correction: Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates. Chemical Communications (Cambridge, England). 51: 1744. PMID 25557011 DOI: 10.1039/C4Cc90486A  0.779
2015 Bordeaux M, Tyagi V, Fasan R. Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts. Angewandte Chemie (International Ed. in English). 54: 1744-8. PMID 25538035 DOI: 10.1002/Anie.201409928  0.819
2015 Sreenilayam G, Fasan R. Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates. Chemical Communications (Cambridge, England). 51: 1532-4. PMID 25504318 DOI: 10.1039/C4Cc08753D  0.81
2015 Bordeaux M, Tyagi V, Fasan R. Enzyme-Catalyzed Cyclopropanation of Aryl-Substituted Olefins Synfacts. 11: 322-322. DOI: 10.1055/S-0034-1380065  0.8
2015 Bordeaux M, Tyagi V, Fasan R. Inside Back Cover: Highly Diastereoselective and Enantioselective Olefin Cyclopropanation Using Engineered Myoglobin-Based Catalysts (Angew. Chem. Int. Ed. 6/2015) Angewandte Chemie International Edition. 54: 1975-1975. DOI: 10.1002/Anie.201500136  0.802
2015 Bordeaux M, Tyagi V, Fasan R. Innenrücktitelbild: Highly Diastereoselective and Enantioselective Olefin Cyclopropanation Using Engineered Myoglobin-Based Catalysts (Angew. Chem. 6/2015) Angewandte Chemie. 127: 1997-1997. DOI: 10.1002/Ange.201500136  0.803
2014 Fasan R. Natural, engineered, and artificial biocatalysts for organic synthesis. Bioorganic & Medicinal Chemistry. 22: 5537-8. PMID 25131959 DOI: 10.1016/J.Bmc.2014.07.039  0.33
2014 Bionda N, Cryan AL, Fasan R. Bioinspired strategy for the ribosomal synthesis of thioether-bridged macrocyclic peptides in bacteria. Acs Chemical Biology. 9: 2008-13. PMID 25079213 DOI: 10.1021/Cb500311K  0.805
2014 Bordeaux M, Singh R, Fasan R. Intramolecular C(sp(3))H amination of arylsulfonyl azides with engineered and artificial myoglobin-based catalysts. Bioorganic & Medicinal Chemistry. 22: 5697-704. PMID 24890656 DOI: 10.1016/J.Bmc.2014.05.015  0.83
2014 Smith JM, Frost JR, Fasan R. Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix. Chemical Communications (Cambridge, England). 50: 5027-30. PMID 24710524 DOI: 10.1039/C4Cc01199F  0.755
2014 Kolev JN, Zaengle JM, Ravikumar R, Fasan R. Enhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis. Chembiochem : a European Journal of Chemical Biology. 15: 1001-10. PMID 24692265 DOI: 10.1002/Cbic.201400060  0.799
2014 Singh R, Bordeaux M, Fasan R. P450-catalyzed intramolecular sp(3) C-H amination with arylsulfonyl azide substrates. Acs Catalysis. 4: 546-552. PMID 24634794 DOI: 10.1021/Cs400893N  0.84
2014 Smith JM, Hill NC, Krasniak PJ, Fasan R. Synthesis of bicyclic organo-peptide hybrids via oxime/intein-mediated macrocyclization followed by disulfide bond formation. Organic & Biomolecular Chemistry. 12: 1135-42. PMID 24395107 DOI: 10.1039/C3Ob42222D  0.804
2014 Kolev JN, O'Dwyer KM, Jordan CT, Fasan R. Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization. Acs Chemical Biology. 9: 164-73. PMID 24206617 DOI: 10.1021/Cb400626W  0.816
2014 Singh R, Bordeaux M, Fasan R. Biocatalytic Intramolecular C–H Amination Synfacts. 10: 434-434. DOI: 10.1055/S-0033-1341037  0.806
2013 Frost JR, Smith JM, Fasan R. Design, synthesis, and diversification of ribosomally derived peptide macrocycles. Current Opinion in Structural Biology. 23: 571-80. PMID 23856642 DOI: 10.1016/J.Sbi.2013.06.015  0.777
2013 Smith JM, Frost JR, Fasan R. Emerging strategies to access peptide macrocycles from genetically encoded polypeptides. The Journal of Organic Chemistry. 78: 3525-31. PMID 23517465 DOI: 10.1021/Jo400119S  0.77
2013 Frost JR, Vitali F, Jacob NT, Brown MD, Fasan R. Macrocyclization of organo-peptide hybrids through a dual bio-orthogonal ligation: insights from structure-reactivity studies. Chembiochem : a European Journal of Chemical Biology. 14: 147-60. PMID 23203912 DOI: 10.1002/Cbic.201200579  0.809
2012 Zhang K, Shafer BM, Demars MD, Stern HA, Fasan R. Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity. Journal of the American Chemical Society. 134: 18695-704. PMID 23121379 DOI: 10.1021/Ja3073462  0.792
2012 Satyanarayana M, Vitali F, Frost JR, Fasan R. Diverse organo-peptide macrocycles via a fast and catalyst-free oxime/intein-mediated dual ligation. Chemical Communications (Cambridge, England). 48: 1461-3. PMID 21897951 DOI: 10.1039/C1Cc13533C  0.767
2012 Fasan R. Tuning P450 enzymes as oxidation catalysts Acs Catalysis. 2: 647-666. DOI: 10.1021/Cs300001X  0.5
2011 Smith JM, Vitali F, Archer SA, Fasan R. Modular assembly of macrocyclic organo-peptide hybrids using synthetic and genetically encoded precursors. Angewandte Chemie (International Ed. in English). 50: 5075-80. PMID 21506227 DOI: 10.1002/Anie.201101331  0.681
2011 Zhang K, El Damaty S, Fasan R. P450 fingerprinting method for rapid discovery of terpene hydroxylating P450 catalysts with diversified regioselectivity. Journal of the American Chemical Society. 133: 3242-5. PMID 21341707 DOI: 10.1021/Ja109590H  0.787
2011 Fasan R, Crook NC, Peters MW, Meinhold P, Buelter T, Landwehr M, Cirino PC, Arnold FH. Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli. Biotechnology and Bioengineering. 108: 500-10. PMID 21246504 DOI: 10.1002/Bit.22984  0.762
2009 Rentmeister A, Arnold FH, Fasan R. Chemo-enzymatic fluorination of unactivated organic compounds. Nature Chemical Biology. 5: 26-8. PMID 19011638 DOI: 10.1038/Nchembio.128  0.511
2008 Fasan R, Meharenna YT, Snow CD, Poulos TL, Arnold FH. Evolutionary history of a specialized p450 propane monooxygenase. Journal of Molecular Biology. 383: 1069-80. PMID 18619466 DOI: 10.1016/J.Jmb.2008.06.060  0.585
2007 Fasan R, Chen MM, Crook NC, Arnold FH. Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties. Angewandte Chemie (International Ed. in English). 46: 8414-8. PMID 17886313 DOI: 10.1002/Anie.200702616  0.541
2007 Fasan R, Arnold FH. Laboratory evolution of P450 alkane monooxygenases Acs National Meeting Book of Abstracts.  0.397
2006 Fasan R, Dias RL, Moehle K, Zerbe O, Obrecht D, Mittl PR, Grütter MG, Robinson JA. Structure-activity studies in a family of beta-hairpin protein epitope mimetic inhibitors of the p53-HDM2 protein-protein interaction. Chembiochem : a European Journal of Chemical Biology. 7: 515-26. PMID 16511824 DOI: 10.1002/Cbic.200500452  0.472
2006 Dias RL, Fasan R, Moehle K, Renard A, Obrecht D, Robinson JA. Protein ligand design: from phage display to synthetic protein epitope mimetics in human antibody Fc-binding peptidomimetics. Journal of the American Chemical Society. 128: 2726-32. PMID 16492060 DOI: 10.1021/Ja057513W  0.505
2004 Fasan R, Dias RL, Moehle K, Zerbe O, Vrijbloed JW, Obrecht D, Robinson JA. Using a beta-hairpin to mimic an alpha-helix: cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction. Angewandte Chemie (International Ed. in English). 43: 2109-12. PMID 15083458 DOI: 10.1002/Anie.200353242  0.526
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