| Year |
Citation |
Score |
| 2023 |
Van Oers TJ, Piercey A, Belovodskiy A, Reiz B, Donnelly BL, Vuong W, Lemieux MJ, Nieman JA, Auclair K, Vederas JC. Deuteration for Metabolic Stabilization of SARS-CoV-2 Inhibitors GC373 and Nirmatrelvir. Organic Letters. 25: 5885-5889. PMID 37523471 DOI: 10.1021/acs.orglett.3c02140 |
0.424 |
|
| 2021 |
Kaabel S, Therien JPD, Deschênes CE, Duncan D, Friščić T, Auclair K. Enzymatic depolymerization of highly crystalline polyethylene terephthalate enabled in moist-solid reaction mixtures. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34257154 DOI: 10.1073/pnas.2026452118 |
0.649 |
|
| 2021 |
Duncan D, Lupien A, Behr MA, Auclair K. Effect of pH on the antimicrobial activity of the macrophage metabolite itaconate. Microbiology (Reading, England). 167. PMID 34020726 DOI: 10.1099/mic.0.001050 |
0.627 |
|
| 2021 |
Guan J, Spry C, Tjhin ET, Yang P, Kittikool T, Howieson VM, Ling H, Starrs L, Duncan D, Burgio G, Saliba KJ, Auclair K. Exploring Heteroaromatic Rings as a Replacement for the Labile Amide of Antiplasmodial Pantothenamides. Journal of Medicinal Chemistry. PMID 33792339 DOI: 10.1021/acs.jmedchem.0c01755 |
0.673 |
|
| 2020 |
Swain A, Bambouskova M, Kim H, Andhey PS, Duncan D, Auclair K, Chubukov V, Simons DM, Roddy TP, Stewart KM, Artyomov MN. Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages. Nature Metabolism. 2: 594-602. PMID 32694786 DOI: 10.1038/s42255-020-0210-0 |
0.62 |
|
| 2020 |
Hammerer F, Ostadjoo S, Dietrich K, Dumont M, Del Rio LF, Friščić T, Auclair K. Rapid mechanoenzymatic saccharification of lignocellulosic biomass without bulk water or chemical pre-treatment Green Chemistry. 22: 3877-3884. DOI: 10.1039/D0Gc00903B |
0.327 |
|
| 2020 |
Kaabel S, Friščić T, Auclair K. Cover Feature: Mechanoenzymatic Transformations in the Absence of Bulk Water: A More Natural Way of Using Enzymes (ChemBioChem 6/2020) Chembiochem. 21: 740-740. DOI: 10.1002/Cbic.202000087 |
0.308 |
|
| 2019 |
Ostadjoo S, Hammerer F, Dietrich K, Dumont MJ, Friščić T, Auclair K. Efficient Enzymatic Hydrolysis of Biomass Hemicellulose in the Absence of Bulk Water. Molecules (Basel, Switzerland). 24. PMID 31756935 DOI: 10.3390/Molecules24234206 |
0.3 |
|
| 2019 |
Kaabel S, Friscic T, Auclair K. Mechanoenzymatic transformations in the absence of bulk water - a more natural way of using enzymes. Chembiochem : a European Journal of Chemical Biology. PMID 31651073 DOI: 10.1002/Cbic.201900567 |
0.371 |
|
| 2019 |
Hammerer F, Ostadjoo S, Friscic T, Auclair K. Towards controlling the reactivity of enzymes in mechanochemistry: inert surfaces protect β-glucosidase activity during ball milling. Chemsuschem. PMID 31593363 DOI: 10.1002/Cssc.201902752 |
0.357 |
|
| 2019 |
Wang Y, Guan J, Di Trani JM, Auclair K, Mittermaier AK. Inhibition and activation of kinases by reaction products: a quick, reporter-free assay. Analytical Chemistry. PMID 31426630 DOI: 10.1021/Acs.Analchem.9B02456 |
0.344 |
|
| 2019 |
Duncan D, Auclair K. The coenzyme A biosynthetic pathway: A new tool for prodrug bioactivation. Archives of Biochemistry and Biophysics. 108069. PMID 31404525 DOI: 10.1016/J.Abb.2019.108069 |
0.683 |
|
| 2019 |
Therien JPD, Hammerer F, Friscic T, Auclair K. Mechanoenzymatic breakdown of chitinous material to N-acetylglucosamine: the benefits of a solvent-less environment. Chemsuschem. PMID 31211476 DOI: 10.1002/Cssc.201901310 |
0.366 |
|
| 2019 |
Ducharme J, Polic V, Auclair K. A Covalently Attached Progesterone Molecule Outcompetes the Binding of Free Progesterone at an Allosteric Site of Cytochrome P450 3A4. Bioconjugate Chemistry. PMID 31083930 DOI: 10.1021/Acs.Bioconjchem.9B00248 |
0.374 |
|
| 2018 |
Guan J, Barnard L, Cresson J, Hoegl A, Chang JH, Strauss E, Auclair K. Probing the ligand preferences of the three types of bacterial pantothenate kinase. Bioorganic & Medicinal Chemistry. PMID 30429095 DOI: 10.1016/J.Bmc.2018.10.042 |
0.356 |
|
| 2018 |
Guan J, Tjhin ET, Howieson VM, Kittikool T, Spry C, Saliba KJ, Auclair K. Structure-activity relationships of antiplasmodial pantothenamide analogs reveal a new way by which triazoles mimic amide bonds. Chemmedchem. PMID 30370998 DOI: 10.1002/Cmdc.201800327 |
0.363 |
|
| 2018 |
Guan J, Vong K, Wee K, Fakhoury J, Dullaghan E, Auclair K. Cellular studies of an aminoglycoside potentiator reveal a new inhibitor of aminoglycoside resistance. Chembiochem : a European Journal of Chemical Biology. PMID 30059603 DOI: 10.1002/Cbic.201800368 |
0.76 |
|
| 2018 |
Polic V, Sevrioukova IF, Auclair K. Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling efficiency. Archives of Biochemistry and Biophysics. PMID 29958895 DOI: 10.1016/J.Abb.2018.06.014 |
0.364 |
|
| 2018 |
Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, ... ... Auclair K, et al. Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Nature. PMID 29670287 DOI: 10.1038/S41586-018-0052-Z |
0.646 |
|
| 2018 |
Tjhin ET, Spry C, Sewell AL, Hoegl A, Barnard L, Sexton AE, Siddiqui G, Howieson VM, Maier AG, Creek DJ, Strauss E, Marquez R, Auclair K, Saliba KJ. Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues. Plos Pathogens. 14: e1006918. PMID 29614109 DOI: 10.1371/Journal.Ppat.1006918 |
0.357 |
|
| 2018 |
Hammerer F, Loots L, Do JL, Therien JPD, Nickels CW, Friscic T, Auclair K. Solvent-free enzyme activity: quick, high-yielding mechano-enzymatic hydrolysis of cellulose into glucose. Angewandte Chemie (International Ed. in English). PMID 29342316 DOI: 10.1002/Anie.201711643 |
0.313 |
|
| 2017 |
Ducharme J, Auclair K. Use of bioconjugation with cytochrome P450 enzymes. Biochimica Et Biophysica Acta. PMID 28625736 DOI: 10.1016/J.Bbapap.2017.06.007 |
0.346 |
|
| 2017 |
Polic V, Auclair K. Allosteric Activation of Cytochrome P450 3A4 via Progesterone Bioconjugation. Bioconjugate Chemistry. PMID 28339191 DOI: 10.1021/Acs.Bioconjchem.6B00604 |
0.368 |
|
| 2017 |
Polic V, Cheong KJ, Hammerer F, Auclair K. Regioselective Epoxidations by Cytochrome P450 3A4 Using a Theobromine Chemical Auxiliary to Predictably Produce N‐Protected β‐ or γ‐Amino Epoxides Advanced Synthesis & Catalysis. 359: 3983-3989. DOI: 10.1002/Adsc.201700637 |
0.393 |
|
| 2016 |
Ducharme J, Auclair K. Enzymes beat chemists in the formation of unnatural bonds. Chembiochem : a European Journal of Chemical Biology. PMID 28026102 DOI: 10.1002/Cbic.201600692 |
0.353 |
|
| 2016 |
Schiavini P, Cheong KJ, Moitessier N, Auclair K. Active site crowding of P450 3A4 as a strategy to alter its selectivity. Chembiochem : a European Journal of Chemical Biology. PMID 27897366 DOI: 10.1002/Cbic.201600546 |
0.375 |
|
| 2016 |
Howieson VM, Tran E, Hoegl A, Fam HL, Fu J, Sivonen K, Li XX, Auclair K, Saliba KJ. Triazole substitution of a labile amide bond stabilizes pantothenamides and improves their antiplasmodial potency. Antimicrobial Agents and Chemotherapy. PMID 27645235 DOI: 10.1128/Aac.01436-16 |
0.369 |
|
| 2016 |
Guan J, Hachey M, Puri L, Howieson V, Saliba KJ, Auclair K. A cross-metathesis approach to novel pantothenamide derivatives. Beilstein Journal of Organic Chemistry. 12: 963-8. PMID 27340487 DOI: 10.3762/Bjoc.12.95 |
0.347 |
|
| 2016 |
Hammerer F, Chang JH, Duncan D, Ruiz AC, Auclair K. Small molecule restores itaconate sensitivity in Salmonella enterica: a potential new approach to treat bacterial infections. Chembiochem : a European Journal of Chemical Biology. PMID 27254798 DOI: 10.1002/Cbic.201600078 |
0.691 |
|
| 2015 |
Mariaule G, De Cesco S, Airaghi F, Kurian J, Schiavini P, Rocheleau S, Huskić I, Auclair K, Mittermaier AK, Moitessier N. 3-Oxo-hexahydro-1H-isoindole-4-carboxylic acid as a Drug Chiral Bicyclic Scaffold: Structure-based Design and Preparation of Conformationally Constrained Covalent and Non-Covalent Prolyl Oligopeptidase Inhibitors. Journal of Medicinal Chemistry. PMID 26619267 DOI: 10.1021/Acs.Jmedchem.5B01296 |
0.39 |
|
| 2015 |
Schiavini P, Pottel J, Moitessier N, Auclair K. Metabolic Instability of Cyanothiazolidine-Based Prolyl Oligopeptidase Inhibitors: a Structural Assignment Challenge and Potential Medicinal Chemistry Implications. Chemmedchem. PMID 26018317 DOI: 10.1002/Cmdc.201500114 |
0.351 |
|
| 2015 |
Auclair K, Polic V. Use of chemical auxiliaries to control p450 enzymes for predictable oxidations at unactivated C-h bonds of substrates. Advances in Experimental Medicine and Biology. 851: 209-28. PMID 26002737 DOI: 10.1007/978-3-319-16009-2_8 |
0.399 |
|
| 2015 |
Freiburger L, Auclair K, Mittermaier A. Global ITC fitting methods in studies of protein allostery. Methods (San Diego, Calif.). 76: 149-61. PMID 25573261 DOI: 10.1016/J.Ymeth.2014.12.018 |
0.332 |
|
| 2015 |
Schiavini P, Pottel J, Moitessier N, Auclair K. Back Cover: Metabolic Instability of Cyanothiazolidine-Based Prolyl Oligopeptidase Inhibitors: a Structural Assignment Challenge and Potential Medicinal Chemistry Implications (ChemMedChem 7/2015) Chemmedchem. 10: 1276-1276. DOI: 10.1002/Cmdc.201590022 |
0.304 |
|
| 2014 |
Freiburger L, Miletti T, Zhu S, Baettig O, Berghuis A, Auclair K, Mittermaier A. Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme. Nature Chemical Biology. 10: 937-42. PMID 25218742 DOI: 10.1038/Nchembio.1626 |
0.32 |
|
| 2014 |
Polic V, Auclair K. Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis. Bioorganic & Medicinal Chemistry. 22: 5547-54. PMID 25035263 DOI: 10.1016/J.Bmc.2014.06.034 |
0.386 |
|
| 2014 |
Hoegl A, Darabi H, Tran E, Awuah E, Kerdo ES, Habib E, Saliba KJ, Auclair K. Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity. Bioorganic & Medicinal Chemistry Letters. 24: 3274-7. PMID 24986662 DOI: 10.1016/J.Bmcl.2014.06.013 |
0.376 |
|
| 2014 |
Awuah E, Ma E, Hoegl A, Vong K, Habib E, Auclair K. Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase. Bioorganic & Medicinal Chemistry. 22: 3083-90. PMID 24814884 DOI: 10.1016/J.Bmc.2014.04.030 |
0.768 |
|
| 2012 |
Vong K, Auclair K. Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase. Medchemcomm. 3: 397-407. PMID 28018574 DOI: 10.1039/C2Md00253A |
0.736 |
|
| 2012 |
Ménard A, Fabra C, Huang Y, Auclair K. Type II ligands as chemical auxiliaries to favor enzymatic transformations by P450 2E1. Chembiochem : a European Journal of Chemical Biology. 13: 2527-36. PMID 23129539 DOI: 10.1002/Cbic.201200524 |
0.35 |
|
| 2012 |
Ménard A, Huang Y, Karam P, Cosa G, Auclair K. Site-specific fluorescent labeling and oriented immobilization of a triple mutant of CYP3A4 via C64. Bioconjugate Chemistry. 23: 826-36. PMID 22433037 DOI: 10.1021/Bc200672S |
0.408 |
|
| 2012 |
Vong K, Tam IS, Yan X, Auclair K. Inhibitors of aminoglycoside resistance activated in cells. Acs Chemical Biology. 7: 470-5. PMID 22217014 DOI: 10.1021/Cb200366U |
0.765 |
|
| 2012 |
Tewari BB, Beaulieu-Houle G, Larsen A, Kengne-Momo R, Auclair K, Butler IS. An overview of molecular spectroscopic studies on theobromine and related alkaloids Applied Spectroscopy Reviews. 47: 163-179. DOI: 10.1080/05704928.2011.634051 |
0.722 |
|
| 2012 |
Vong K, Auclair K. Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase Medchemcomm. 3: 397-407. DOI: 10.1039/c2md00253a |
0.728 |
|
| 2012 |
Larsen AT, Lai T, Polic V, Auclair K. Dual use of a chemical auxiliary: Molecularly imprinted polymers for the selective recovery of products from biocatalytic reaction mixtures Green Chemistry. 14: 2206-2211. DOI: 10.1039/C2Gc35604J |
0.745 |
|
| 2011 |
Szychowski J, Kondo J, Zahr O, Auclair K, Westhof E, Hanessian S, Keillor JW. Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues. Chemmedchem. 6: 1961-6. PMID 21905229 DOI: 10.1002/Cmdc.201100346 |
0.341 |
|
| 2011 |
Larsen AT, May EM, Auclair K. Predictable stereoselective and chemoselective hydroxylations and epoxidations with P450 3A4. Journal of the American Chemical Society. 133: 7853-8. PMID 21528858 DOI: 10.1021/Ja200551Y |
0.765 |
|
| 2011 |
Akinnusi TO, Vong K, Auclair K. Geminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity. Bioorganic & Medicinal Chemistry. 19: 2696-706. PMID 21440446 DOI: 10.1016/J.Bmc.2011.02.053 |
0.757 |
|
| 2011 |
Freiburger LA, Baettig OM, Sprules T, Berghuis AM, Auclair K, Mittermaier AK. Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme. Nature Structural & Molecular Biology. 18: 288-94. PMID 21278754 DOI: 10.1038/Nsmb.1978 |
0.343 |
|
| 2011 |
Yan X, Akinnusi TO, Larsen AT, Auclair K. Synthesis of 4'-aminopantetheine and derivatives to probe aminoglycoside N-6'-acetyltransferase. Organic & Biomolecular Chemistry. 9: 1538-46. PMID 21225062 DOI: 10.1039/C0Ob01018A |
0.783 |
|
| 2011 |
Szychowski J, Kondo J, Zahr O, Auclair K, Westhof E, Hanessian S, Keillor JW. Inside Cover: Inhibition of Aminoglycoside-Deactivating Enzymes APH(3′)-IIIa and AAC(6′)-Ii by Amphiphilic Paromomycin O2′′-Ether Analogues (ChemMedChem 11/2011) Chemmedchem. 6: 1942-1942. DOI: 10.1002/Cmdc.201190048 |
0.378 |
|
| 2009 |
Gao F, Yan X, Auclair K. Synthesis of a phosphonate-linked aminoglycoside-coenzyme a bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 2064-70. PMID 19152351 DOI: 10.1002/Chem.200802172 |
0.45 |
|
| 2009 |
Zhao J, Auclair K. The activity of human CYP2D6 in low water organic solvents. Biotechnology and Bioengineering. 102: 1268-72. PMID 18988262 DOI: 10.1002/Bit.22143 |
0.418 |
|
| 2008 |
Gao F, Yan X, Zahr O, Larsen A, Vong K, Auclair K. Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-CoA bisubstrates as mechanistic probes for aminoglycoside N-6'-acetyltransferase. Bioorganic & Medicinal Chemistry Letters. 18: 5518-22. PMID 18805003 DOI: 10.1016/J.Bmcl.2008.09.004 |
0.768 |
|
| 2008 |
Magalhães MLB, Vetting MW, Gao F, Freiburger L, Auclair K, Blanchard JS. Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6′-N-acetyltransferase Biochemistry. 47: 579-584. PMID 18095712 DOI: 10.1021/Bi701957C |
0.435 |
|
| 2007 |
Chefson A, Zhao J, Auclair K. Sugar-mediated lyoprotection of purified human CYP3A4 and CYP2D6. Journal of Biotechnology. 130: 436-40. PMID 17599599 DOI: 10.1016/J.Jbiotec.2007.05.009 |
0.403 |
|
| 2007 |
Chefson A, Auclair K. CYP3A4 activity in the presence of organic cosolvents, ionic liquids, or water-immiscible organic solvents. Chembiochem : a European Journal of Chemical Biology. 8: 1189-97. PMID 17526062 DOI: 10.1002/Cbic.200700128 |
0.365 |
|
| 2007 |
Zhao J, Tan E, Ferras J, Auclair K. Activity of human P450 2D6 in biphasic solvent systems. Biotechnology and Bioengineering. 98: 508-13. PMID 17461428 DOI: 10.1002/Bit.21449 |
0.358 |
|
| 2007 |
Yan X, Gao F, Yotphan S, Bakirtzian P, Auclair K. The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6'-N-acetyltransferase and the role of 6'-NH2 in antibacterial activity. Bioorganic & Medicinal Chemistry. 15: 2944-51. PMID 17317190 DOI: 10.1016/J.Bmc.2007.02.009 |
0.438 |
|
| 2006 |
Chefson A, Auclair K. Progress towards the easier use of P450 enzymes. Molecular Biosystems. 2: 462-9. PMID 17216026 DOI: 10.1039/B607001A |
0.401 |
|
| 2006 |
Gao F, Yan X, Shakya T, Baettig OM, Ait-Mohand-Brunet S, Berghuis AM, Wright GD, Auclair K. Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases. Journal of Medicinal Chemistry. 49: 5273-81. PMID 16913716 DOI: 10.1021/Jm060732N |
0.475 |
|
| 2006 |
Gao F, Auclair K. Highly efficient P(III)-to-P(V) oxidative rearrangement Phosphorus, Sulfur and Silicon and the Related Elements. 181: 159-165. DOI: 10.1080/104265090969270 |
0.306 |
|
| 2005 |
Gao F, Yan X, Baettig OM, Berghuis AM, Auclair K. Regio- and chemoselective 6'-N-derivatization of aminoglycosides: bisubstrate inhibitors as probes to study aminoglycoside 6'-N-acetyltransferases. Angewandte Chemie (International Ed. in English). 44: 6859-62. PMID 16206301 DOI: 10.1002/Anie.200501399 |
0.324 |
|
| 2004 |
Gaudineau C, Auclair K. Inhibition of human P450 enzymes by nicotinic acid and nicotinamide. Biochemical and Biophysical Research Communications. 317: 950-6. PMID 15081432 DOI: 10.1016/J.Bbrc.2004.03.137 |
0.336 |
|
| 2004 |
Li Y, Syvitski RT, Auclair K, de Montellano PR, La Mar GN. 1H NMR investigation of the solution structure of substrate-free human heme oxygenase: comparison to the cyanide-inhibited, substrate-bound complex. The Journal of Biological Chemistry. 279: 10195-205. PMID 14660632 DOI: 10.1074/Jbc.M308379200 |
0.316 |
|
| 2003 |
Li Y, Syvitski RT, Auclair K, Ortiz de Montellano P, La Mar GN. Solution 1H, 15N NMR spectroscopic characterization of substrate-bound, cyanide-inhibited human heme oxygenase: water occupation of the distal cavity. Journal of the American Chemical Society. 125: 13392-403. PMID 14583035 DOI: 10.1021/Ja036176T |
0.539 |
|
| 2003 |
Sorensen JL, Auclair K, Kennedy J, Hutchinson CR, Vederas JC. Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes. Organic & Biomolecular Chemistry. 1: 50-9. PMID 12929390 DOI: 10.1039/B207721C |
0.641 |
|
| 2003 |
Auclair K, Huang HW, Moënne-Loccoz P, Ortiz de Montellano PR. Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae. Protein Expression and Purification. 28: 340-9. PMID 12699699 DOI: 10.1016/S1046-5928(02)00699-X |
0.527 |
|
| 2002 |
Syvitski RT, Li Y, Auclair K, Ortiz De Montellano PR, La Mar GN. 1H NMR detection of immobilized water molecules within a strong distal hydrogen-bonding network of substrate-bound human heme oxygenase-1. Journal of the American Chemical Society. 124: 14296-7. PMID 12452690 DOI: 10.1021/Ja028108X |
0.53 |
|
| 2002 |
Li Y, Syvitski RT, Auclair K, Wilks A, Ortiz De Montellano PR, La Mar GN. Solution NMR characterization of an unusual distal H-bond network in the active site of the cyanide-inhibited, human heme oxygenase complex of the symmetric substrate, 2,4-dimethyldeuterohemin. The Journal of Biological Chemistry. 277: 33018-31. PMID 12070167 DOI: 10.1074/Jbc.M204216200 |
0.537 |
|
| 2002 |
Auclair K, Hu Z, Little DM, Ortiz De Montellano PR, Groves JT. Revisiting the mechanism of P450 enzymes with the radical clocks norcarane and spiro[2,5]octane. Journal of the American Chemical Society. 124: 6020-7. PMID 12022835 DOI: 10.1021/Ja025608H |
0.471 |
|
| 2001 |
Auclair K, Moënne-Loccoz P, Ortiz de Montellano PR. Roles of the proximal heme thiolate ligand in cytochrome p450(cam). Journal of the American Chemical Society. 123: 4877-85. PMID 11457314 DOI: 10.1021/Ja0040262 |
0.531 |
|
| 2001 |
Auclair K, Kennedy J, Hutchinson CR, Vederas JC. Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus. Bioorganic & Medicinal Chemistry Letters. 11: 1527-31. PMID 11412974 DOI: 10.1016/S0960-894X(01)00290-6 |
0.48 |
|
| 2001 |
Sutherland A, Auclair K, Vederas JC. Recent advances in the biosynthetic studies of lovastatin. Current Opinion in Drug Discovery & Development. 4: 229-36. PMID 11378962 |
0.509 |
|
| 2001 |
La Mar GN, Asokan A, Espiritu B, Yeh DC, Auclair K, Ortiz De Montellano PR. Solution 1H NMR of the active site of substrate-bound, cyanide-inhibited human heme oxygenase. comparison to the crystal structure of the water-ligated form. The Journal of Biological Chemistry. 276: 15676-87. PMID 11297521 DOI: 10.1074/Jbc.M009974200 |
0.521 |
|
| 2000 |
Hutchinson CR, Kennedy J, Park C, Kendrew S, Auclair K, Vederas J. Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases. Antonie Van Leeuwenhoek. 78: 287-95. PMID 11386351 DOI: 10.1023/A:1010294330190 |
0.521 |
|
| 2000 |
Auclair K, Sutherland A, Kennedy J, Witter DJ, Van den Heever JP, Hutchinson CR, Vederas JC. Lovastatin nonaketide synthase catalyzes an intramolecular diels - Alder reaction of a substrate analogue [7] Journal of the American Chemical Society. 122: 11519-11520. DOI: 10.1021/Ja003216+ |
0.507 |
|
| 1999 |
Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, Hutchinson CR. Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. Science (New York, N.Y.). 284: 1368-72. PMID 10334994 DOI: 10.1126/Science.284.5418.1368 |
0.539 |
|
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