Linda Jen-Jacobson - Publications

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 
Area:
General Biophysics

45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ghosh S, Lawless MJ, Brubaker HJ, Singewald K, Kurpiewski MR, Jen-Jacobson L, Saxena S. Cu2+-based distance measurements by pulsed EPR provide distance constraints for DNA backbone conformations in solution. Nucleic Acids Research. PMID 32095832 DOI: 10.1093/Nar/Gkaa133  0.445
2018 Sinha K, Sangani S, Rule G, Jen-Jacobson L. Backbone assignments and ILV methyl assignments for EcoRV bound to 16-mer double stranded DNA (GCAAAGATATCTTTCG) without Lu3+ Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr25701  0.5
2016 Sinha K, Sangani SS, Kehr AD, Rule GS, Jen-Jacobson L. Metal Ion Binding at the Catalytic Site Induces Widely Distributed Changes in a Sequence Specific Protein-DNA Complex. Biochemistry. PMID 27786446 DOI: 10.1021/Acs.Biochem.6B00919  0.49
2015 Ghindilis AL, Smith MW, Simon HM, Seoudi IA, Yazvenko NS, Murray IA, Fu X, Smith K, Jen-Jacobson L, Xu SY. Restriction Cascade Exponential Amplification (RCEA) assay with an attomolar detection limit: a novel, highly specific, isothermal alternative to qPCR. Scientific Reports. 5: 7737. PMID 25583452 DOI: 10.1038/Srep07737  0.412
2014 Ji M, Tan L, Jen-Jacobson L, Saxena S. Insights into copper coordination in the EcoRI-DNA complex by ESR spectroscopy. Molecular Physics. 112: 3173-3182. PMID 25750461 DOI: 10.1080/00268976.2014.934313  0.478
2014 Sapienza PJ, Niu T, Kurpiewski MR, Grigorescu A, Jen-Jacobson L. Thermodynamic and structural basis for relaxation of specificity in protein-DNA recognition. Journal of Molecular Biology. 426: 84-104. PMID 24041571 DOI: 10.1016/J.Jmb.2013.09.005  0.491
2014 Trakselis MA, Bauer RJ, Lin H, Jen-Jacobson L. Complex Temperature Dependent Equilibria Dictate DNA Polymerase Exchange Processes during Synthesis Biophysical Journal. 106: 274a. DOI: 10.1016/J.Bpj.2013.11.1603  0.536
2013 Sinha K, Jen-Jacobson L, Rule GS. Divide and conquer is always best: sensitivity of methyl correlation experiments. Journal of Biomolecular Nmr. 56: 331-5. PMID 23771591 DOI: 10.1007/S10858-013-9751-9  0.328
2013 Ruthstein S, Ji M, Mehta P, Jen-Jacobson L, Saxena S. Sensitive Cu2+-Cu2+ distance measurements in a protein-DNA complex by double-quantum coherence ESR. The Journal of Physical Chemistry. B. 117: 6227-30. PMID 23631829 DOI: 10.1021/Jp4037149  0.371
2012 Lin HK, Chase SF, Laue TM, Jen-Jacobson L, Trakselis MA. Differential temperature-dependent multimeric assemblies of replication and repair polymerases on DNA increase processivity. Biochemistry. 51: 7367-82. PMID 22906116 DOI: 10.1021/Bi300956T  0.541
2012 Yang Z, Kurpiewski MR, Ji M, Townsend JE, Mehta P, Jen-Jacobson L, Saxena S. ESR spectroscopy identifies inhibitory Cu2+ sites in a DNA-modifying enzyme to reveal determinants of catalytic specificity. Proceedings of the National Academy of Sciences of the United States of America. 109: E993-1000. PMID 22493217 DOI: 10.1073/Pnas.1200733109  0.488
2012 Sarver JL, Townsend JE, Rajapakse G, Jen-Jacobson L, Saxena S. Simulating the dynamics and orientations of spin-labeled side chains in a protein-DNA complex. The Journal of Physical Chemistry. B. 116: 4024-33. PMID 22404310 DOI: 10.1021/Jp211094N  0.389
2011 Sinha K, Jen-Jacobson L, Rule GS. Specific labeling of threonine methyl groups for NMR studies of protein-nucleic acid complexes. Biochemistry. 50: 10189-91. PMID 22039762 DOI: 10.1021/Bi201496D  0.378
2011 Hancock SP, Hiller DA, Perona JJ, Jen-Jacobson L. The energetic contribution of induced electrostatic asymmetry to DNA bending by a site-specific protein. Journal of Molecular Biology. 406: 285-312. PMID 21167173 DOI: 10.1016/J.Jmb.2010.12.012  0.579
2011 Sarver J, Stone K, Townsend J, Sapienza P, Jen-Jacobson L, Saxena S. In the Arms of EcoRI - probing the Binding Specificity of the Restriction Endonuclease Using Electron Spin Resonance Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.995  0.484
2011 Ji M, Yang Z, Mehta P, Jen-Jacobson L, Saxena S. Insights on Copper Coordination and Reactivity of Endonuclease EcoRI by ESR Spectroscopy and Modeling Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.594  0.354
2010 Dylla-Spears R, Townsend JE, Jen-Jacobson L, Sohn LL, Muller SJ. Single-molecule sequence detection via microfluidic planar extensional flow at a stagnation point. Lab On a Chip. 10: 1543-9. PMID 20358051 DOI: 10.1039/B926847B  0.499
2009 Dylla-Spears R, Townsend JE, Sohn LL, Jen-Jacobson L, Muller SJ. Fluorescent marker for direct detection of specific dsDNA sequences. Analytical Chemistry. 81: 10049-54. PMID 19908852 DOI: 10.1021/Ac9019895  0.461
2009 Mikheikin AL, Lin HK, Mehta P, Jen-Jacobson L, Trakselis MA. A trimeric DNA polymerase complex increases the native replication processivity. Nucleic Acids Research. 37: 7194-205. PMID 19773426 DOI: 10.1093/Nar/Gkp767  0.574
2009 Townsend JE, Stone K, Yang Z, Sarver J, Saxena S, Jen-Jacobson L. The Enfolding Arms of EcoRI Endonuclease as Probed by ESR Experiments Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.222  0.57
2008 Stone KM, Townsend JE, Sarver J, Sapienza PJ, Saxena S, Jen-Jacobson L. Electron spin resonance shows common structural features for different classes of EcoRI-DNA complexes. Angewandte Chemie (International Ed. in English). 47: 10192-4. PMID 19021169 DOI: 10.1002/Anie.200803588  0.412
2008 VanderVeen LA, Harris TM, Jen-Jacobson L, Marnett LJ. Formation of DNA-protein cross-links between gamma-hydroxypropanodeoxyguanosine and EcoRI. Chemical Research in Toxicology. 21: 1733-8. PMID 18690724 DOI: 10.1021/Tx800092G  0.389
2007 Sapienza PJ, Rosenberg JM, Jen-Jacobson L. Structural and thermodynamic basis for enhanced DNA binding by a promiscuous mutant EcoRI endonuclease. Structure (London, England : 1993). 15: 1368-82. PMID 17997963 DOI: 10.1016/J.Str.2007.09.014  0.442
2005 Sapienza PJ, Dela Torre CA, McCoy WH, Jana SV, Jen-Jacobson L. Thermodynamic and kinetic basis for the relaxed DNA sequence specificity of "promiscuous" mutant EcoRI endonucleases. Journal of Molecular Biology. 348: 307-24. PMID 15811370 DOI: 10.1016/J.Jmb.2005.02.051  0.517
2004 Kurpiewski MR, Engler LE, Wozniak LA, Kobylanska A, Koziolkiewicz M, Stec WJ, Jen-Jacobson L. Mechanisms of coupling between DNA recognition specificity and catalysis in EcoRI endonuclease. Structure (London, England : 1993). 12: 1775-88. PMID 15458627 DOI: 10.1016/J.Str.2004.07.016  0.53
2004 Shuttleworth G, Fogg MJ, Kurpiewski MR, Jen-Jacobson L, Connolly BA. Recognition of the pro-mutagenic base uracil by family B DNA polymerases from archaea. Journal of Molecular Biology. 337: 621-34. PMID 15019782 DOI: 10.1016/J.Jmb.2004.01.021  0.548
2001 Engler LE, Sapienza P, Dorner LF, Kucera R, Schildkraut I, Jen-Jacobson L. The energetics of the interaction of BamHI endonuclease with its recognition site GGATCC Journal of Molecular Biology. 307: 619-636. PMID 11254386 DOI: 10.1006/Jmbi.2000.4428  0.538
2001 Watrob H, Liu W, Chen Y, Bartlett SG, Jen-Jacobson L, Barkley MD. Solution conformation of EcoRI restriction endonuclease changes upon binding of cognate DNA and Mg2+ cofactor Biochemistry. 40: 683-692. PMID 11170385 DOI: 10.1021/bi002055j  0.441
2000 Jen-Jacobson L, Engler LE, Jacobson LA. Structural and thermodynamic strategies for site-specific DNA binding proteins Structure. 8: 1015-1023. PMID 11080623 DOI: 10.1016/S0969-2126(00)00501-3  0.587
2000 Jen-Jacobson L, Engler LE, Ames JT, Kurpiewski MR, Grigorescu A. Thermodynamic Parameters of Specific and Nonspecific Protein-DNA Binding Supramolecular Chemistry. 12: 143-160. DOI: 10.1080/10610270008027446  0.556
1999 Malygin EG, Zinoviev VV, Petrov NA, Evdokimov AA, Jen-Jacobson L, Kossykh VG, Hattman S. Effect of base analog substitutions in the specific GATC site on binding and methylation of oligonucleotide duplexes by the bacteriophage T4 Dam DNA-[N6-adenine] methyltransferase Nucleic Acids Research. 27: 1135-1144. PMID 9927748 DOI: 10.1093/Nar/27.4.1135  0.454
1998 Liu W, Chen Y, Watrob H, Bartlett SG, Jen-Jacobson L, Barkley MD. N-termini of EcoRI restriction endonuclease dimer are in close proximity on the protein surface. Biochemistry. 37: 15457-65. PMID 9799508 DOI: 10.1021/Bi980557F  0.42
1997 Jen-Jacobson L. Protein-DNA recognition complexes: Conservation of structure and binding energy in the transition state Biopolymers - Nucleic Acid Sciences Section. 44: 153-180. PMID 9354759 DOI: 10.1002/(Sici)1097-0282(1997)44:2<153::Aid-Bip4>3.0.Co;2-U  0.563
1997 Engler LE, Welch KK, Jen-Jacobson L. Specific binding by EcoRV endonuclease to its DNA recognition site GATATC Journal of Molecular Biology. 269: 82-101. PMID 9193002 DOI: 10.1006/Jmbi.1997.1027  0.487
1996 Kurpiewski MR, Koziolkiewicz M, Wilk A, Stec WJ, Jen-Jacobson L. Chiral phosphorothioates as probes of protein interactions with individual DNA phosphoryl oxygens: Essential interactions of EcoRI endonuclease with the phosphate at pGAATTC Biochemistry. 35: 8846-8854. PMID 8688420 DOI: 10.1021/Bi960261E  0.427
1996 Jen-Jacobson L, Engler LE, Lesser DR, Kurpiewski MR, Yee C, McVerry B. Structural adaptations in the interaction of EcoRI endonuclease with methylated GAATTC sites Embo Journal. 15: 2870-2882. PMID 8654385  0.471
1995 Jen-Jacobson L. Structural-Perturbation approaches to thermodynamics of site-specific protein-DNA interactions Methods in Enzymology. 259: 305-344. PMID 8538460 DOI: 10.1016/0076-6879(95)59050-1  0.525
1993 Lesser DR, Kurpiewski MR, Waters T, Connolly BA, Jen-Jacobson L. Facilitated distortion of the DNA site enhances EcoRI endonuclease-DNA recognition Proceedings of the National Academy of Sciences of the United States of America. 90: 7548-7552. PMID 8356054 DOI: 10.1073/Pnas.90.16.7548  0.496
1992 Lesser DR, Grajkowski A, Kurpiewski MR, Koziolkiewicz M, Stec WJ, Jen-Jacobson L. Stereoselective interaction with chiral phosphorothioates at the central DNA kink of the EcoRI endonuclease-GAATTC complex Journal of Biological Chemistry. 267: 24810-24818. PMID 1447218  0.463
1990 Lesser DR, Kurpiewski MR, Jen-Jacobson L. The energetic basis of specificity in the Eco RI endonuclease-DNA interaction Science. 250: 776-786. PMID 2237428 DOI: 10.1126/Science.2237428  0.539
1988 Becker MM, Lesser D, Kurpiewski M, Baranger A, Jen-Jacobson L. 'Ultraviolet footprinting' accurately maps sequence-specific contacts and DNA kinking in the EcoRI endonuclease-DNA complex Proceedings of the National Academy of Sciences of the United States of America. 85: 6247-6251. PMID 2842760 DOI: 10.1073/Pnas.85.17.6247  0.562
1986 Jen-Jacobson L, Lesser D, Kurpiewski M. The enfolding arms of EcoRI endonuclease: Role in DNA binding and cleavage Cell. 45: 619-629. PMID 3011275 DOI: 10.1016/0092-8674(86)90294-1  0.548
1984 Grable J, Frederick CA, Samudzi C, Jen-Jacobson L, Lesser D, Greene P, Boyer HW, Itakura K, Rosenberg JM. Two-fold symmetry of crystalline DNA-EcoRI endonuclease recognition complexes. Journal of Biomolecular Structure & Dynamics. 1: 1149-60. PMID 6400815 DOI: 10.1080/07391102.1984.10507509  0.505
1984 Frederick CA, Grable J, Melia M, Samudzi C, Jen-Jacobson L, Wang BC, Greene P, Boyer HW, Rosenberg JM. Kinked DNA in crystalline complex with EcoRI endonuclease. Nature. 309: 327-31. PMID 6328307 DOI: 10.1038/309327A0  0.565
1983 Jen-Jacobson L, Kurpiewski M, Lesser D, Grable J, Boyer HW, Rosenberg JM, Greene PJ. Coordinate ion pair formation between EcoRI endonuclease and DNA. The Journal of Biological Chemistry. 258: 14638-46. PMID 6315732  0.416
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