| Year |
Citation |
Score |
| 2015 |
Cherry AL, Dennis CA, Baron A, Eisele LE, Thommes PA, Jaeger J. Hydrophobic and charged residues in the C-terminal arm of hepatitis C virus RNA-dependent RNA polymerase regulate initiation and elongation. Journal of Virology. 89: 2052-63. PMID 25428878 DOI: 10.1128/Jvi.01106-14 |
0.51 |
|
| 2013 |
Gridley CL, Rangarajan S, Firbank S, Dalal S, Sweasy JB, Jaeger J. Structural changes in the hydrophobic hinge region adversely affect the activity and fidelity of the I260Q mutator DNA polymerase β. Biochemistry. 52: 4422-32. PMID 23651085 DOI: 10.1021/Bi301368F |
0.52 |
|
| 2013 |
Curti E, Jaeger J. Residues Arg283, Arg285, and Ile287 in the nucleotide binding pocket of bovine viral diarrhea virus NS5B RNA polymerase affect catalysis and fidelity. Journal of Virology. 87: 199-207. PMID 23077294 DOI: 10.1128/JVI.06968-11 |
0.331 |
|
| 2012 |
Li Y, Gridley CL, Jaeger J, Sweasy JB, Schlick T. Unfavorable electrostatic and steric interactions in DNA polymerase β E295K mutant interfere with the enzyme's pathway. Journal of the American Chemical Society. 134: 9999-10010. PMID 22651551 DOI: 10.1021/Ja300361R |
0.651 |
|
| 2012 |
Murphy DL, Donigan KA, Jaeger J, Sweasy JB. The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator. Biochemistry. 51: 5269-75. PMID 22650412 DOI: 10.1021/Bi3003583 |
0.631 |
|
| 2012 |
Nemec AA, Donigan KA, Murphy DL, Jaeger J, Sweasy JB. Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation. The Journal of Biological Chemistry. 287: 23840-9. PMID 22573322 DOI: 10.1074/Jbc.M112.362111 |
0.58 |
|
| 2011 |
Murphy DL, Jaeger J, Sweasy JB. A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity. Journal of the American Chemical Society. 133: 6279-87. PMID 21452873 DOI: 10.1021/Ja111099B |
0.577 |
|
| 2010 |
Yamtich J, Starcevic D, Lauper J, Smith E, Shi I, Rangarajan S, Jaeger J, Sweasy JB. Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Biochemistry. 49: 2326-34. PMID 20108981 DOI: 10.1021/Bi901735A |
0.743 |
|
| 2009 |
Lin GC, Jaeger J, Eckert KA, Sweasy JB. Loop II of DNA polymerase beta is important for discrimination during substrate binding. Dna Repair. 8: 182-9. PMID 19013261 DOI: 10.1016/J.Dnarep.2008.10.006 |
0.486 |
|
| 2008 |
Dalal S, Starcevic D, Jaeger J, Sweasy JB. The I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates. Biochemistry. 47: 12118-25. PMID 18937502 DOI: 10.1021/Bi8011548 |
0.551 |
|
| 2008 |
Murphy DL, Kosa J, Jaeger J, Sweasy JB. The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding. Biochemistry. 47: 8048-57. PMID 18616290 DOI: 10.1021/Bi702104Y |
0.557 |
|
| 2008 |
Dalal S, Chikova A, Jaeger J, Sweasy JB. The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient. Nucleic Acids Research. 36: 411-22. PMID 18039710 DOI: 10.1093/Nar/Gkm1053 |
0.525 |
|
| 2007 |
Lin GC, Jaeger J, Sweasy JB. Loop II of DNA polymerase beta is important for polymerization activity and fidelity. Nucleic Acids Research. 35: 2924-35. PMID 17439962 DOI: 10.1093/Nar/Gkm126 |
0.468 |
|
| 2006 |
Cramer J, Jaeger J, Restle T. Biochemical and pre-steady-state kinetic characterization of the hepatitis C virus RNA polymerase (NS5BDelta21, HC-J4). Biochemistry. 45: 3610-9. PMID 16533043 DOI: 10.1021/Bi051483S |
0.338 |
|
| 2005 |
Dennis CA, Baron A, Grossmann JG, Mazaleyrat S, Harris M, Jaeger J. Co-translational myristoylation alters the quaternary structure of HIV-1 Nef in solution. Proteins. 60: 658-69. PMID 16021629 DOI: 10.1002/Prot.20544 |
0.321 |
|
| 2005 |
Starcevic D, Dalal S, Jaeger J, Sweasy JB. The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry. The Journal of Biological Chemistry. 280: 28388-93. PMID 15901725 DOI: 10.1074/Jbc.M502178200 |
0.497 |
|
| 1999 |
Murray JM, Saysell CG, Wilmot CM, Tambyrajah WS, Jaeger J, Knowles PF, Phillips SEV, McPherson MJ. The active site base controls cofactor reactivity in Escherichia coli amine oxidase: X-ray crystallographic studies with mutational variants Biochemistry. 38: 8217-8227. PMID 10387067 DOI: 10.1021/Bi9900469 |
0.503 |
|
| 1998 |
Jaeger J, Restle T, Steitz TA. The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor. The Embo Journal. 17: 4535-42. PMID 9687519 DOI: 10.1093/Emboj/17.15.4535 |
0.409 |
|
| 1998 |
Coyle JE, Jaeger J, Gross M, Robinson CV, Radford SE. Structural and mechanistic consequences of polypeptide binding by GroEL. Folding & Design. 2: R93-104. PMID 9427006 DOI: 10.1016/S1359-0278(97)00046-1 |
0.342 |
|
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