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John E. Le Lay, Ph.D. - Publications

Affiliations: 
2004 Vanderbilt University, Nashville, TN 
Area:
Molecular Biology
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19 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Kim JH, Hedrick S, Tsai WW, Wiater E, Le Lay J, Kaestner KH, Leblanc M, Loar A, Montminy M. CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078378 DOI: 10.1073/Pnas.1712616114  0.326
2015 Luan B, Yoon YS, Le Lay J, Kaestner KH, Hedrick S, Montminy M. CREB pathway links PGE2 signaling with macrophage polarization. Proceedings of the National Academy of Sciences of the United States of America. PMID 26644581 DOI: 10.1073/pnas.1519644112  0.364
2015 Bernstein DL, Le Lay JE, Ruano EG, Kaestner KH. TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts. The Journal of Clinical Investigation. 125: 1998-2006. PMID 25866970 DOI: 10.1172/Jci77321  0.317
2014 Shin S, Le Lay J, Everett LJ, Gupta R, Rafiq K, Kaestner KH. CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells. Molecular Metabolism. 3: 803-12. PMID 25379405 DOI: 10.1016/J.Molmet.2014.08.001  0.361
2014 Lee D, Le Lay J, Kaestner KH. The transcription factor CREB has no non-redundant functions in hepatic glucose metabolism in mice. Diabetologia. 57: 1242-8. PMID 24595858 DOI: 10.1007/S00125-014-3203-2  0.332
2014 Jiao Y, Le Lay J, Yu M, Naji A, Kaestner KH. Elevated mouse hepatic betatrophin expression does not increase human β-cell replication in the transplant setting. Diabetes. 63: 1283-8. PMID 24353178 DOI: 10.2337/Db13-1435  0.345
2013 Jiao Y, Rieck S, Le Lay J, Kaestner KH. CISH has no non-redundant functions in glucose homeostasis or beta cell proliferation during pregnancy in mice. Diabetologia. 56: 2435-45. PMID 23949579 DOI: 10.1007/S00125-013-3014-X  0.476
2013 Everett LJ, Le Lay J, Lukovac S, Bernstein D, Steger DJ, Lazar MA, Kaestner KH. Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver. Bmc Genomics. 14: 337. PMID 23682854 DOI: 10.1186/1471-2164-14-337  0.312
2011 Miller RA, Chu Q, Le Lay J, Scherer PE, Ahima RS, Kaestner KH, Foretz M, Viollet B, Birnbaum MJ. Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. The Journal of Clinical Investigation. 121: 2518-28. PMID 21606593 DOI: 10.1172/Jci45942  0.308
2011 Gao Y, Schug J, McKenna LB, Le Lay J, Kaestner KH, Greenbaum LE. Tissue-specific regulation of mouse microRNA genes in endoderm-derived tissues. Nucleic Acids Research. 39: 454-63. PMID 20843784 DOI: 10.1093/Nar/Gkq782  0.332
2010 Gao N, Le Lay J, Qin W, Doliba N, Schug J, Fox AJ, Smirnova O, Matschinsky FM, Kaestner KH. Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. Molecular Endocrinology (Baltimore, Md.). 24: 1594-604. PMID 20534694 DOI: 10.1210/Me.2009-0513  0.603
2010 Bhandare R, Schug J, Le Lay J, Fox A, Smirnova O, Liu C, Naji A, Kaestner KH. Genome-wide analysis of histone modifications in human pancreatic islets. Genome Research. 20: 428-33. PMID 20181961 DOI: 10.1101/Gr.102038.109  0.326
2009 Le Lay J, Tuteja G, White P, Dhir R, Ahima R, Kaestner KH. CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis. Cell Metabolism. 10: 55-62. PMID 19583954 DOI: 10.1016/J.Cmet.2009.06.006  0.384
2009 Golson ML, Le Lay J, Gao N, Brämswig N, Loomes KM, Oakey R, May CL, White P, Kaestner KH. Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. Mechanisms of Development. 126: 687-99. PMID 19501159 DOI: 10.1016/J.Mod.2009.05.005  0.397
2008 Wang H, Peiris TH, Mowery A, Le Lay J, Gao Y, Greenbaum LE. CCAAT/enhancer binding protein-beta is a transcriptional regulator of peroxisome-proliferator-activated receptor-gamma coactivator-1alpha in the regenerating liver. Molecular Endocrinology (Baltimore, Md.). 22: 1596-605. PMID 18467525 DOI: 10.1210/me.2007-0388  0.43
2007 Wang H, Larris B, Peiris TH, Zhang L, Le Lay J, Gao Y, Greenbaum LE. C/EBPbeta activates E2F-regulated genes in vivo via recruitment of the coactivator CREB-binding protein/P300. The Journal of Biological Chemistry. 282: 24679-88. PMID 17599912 DOI: 10.1074/jbc.M705066200  0.376
2006 Le Lay J, Stein R. Involvement of PDX-1 in activation of human insulin gene transcription. The Journal of Endocrinology. 188: 287-94. PMID 16461554 DOI: 10.1677/Joe.1.06510  0.616
2006 Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E, Sosa-Pineda B, Stein R. MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Diabetes. 55: 297-304. PMID 16443760 DOI: 10.2337/Diabetes.55.02.06.Db05-0946  0.348
2004 Le Lay J, Matsuoka TA, Henderson E, Stein R. Identification of a novel PDX-1 binding site in the human insulin gene enhancer. The Journal of Biological Chemistry. 279: 22228-35. PMID 15028719 DOI: 10.1074/Jbc.M312673200  0.626
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