| Year |
Citation |
Score |
| 2020 |
Sabbah M, Mendes V, Vistal RG, Dias DMG, Záhorszká M, Mikušová K, Korduláková J, Coyne AG, Blundell TL, Abell C. Correction to Fragment-Based Design of InhA Inhibitors. Journal of Medicinal Chemistry. PMID 32697583 DOI: 10.1021/Acs.Jmedchem.0C01187 |
0.692 |
|
| 2020 |
Ribeiro JA, Hammer AJS, Libreros-Z Uacute Ntilde Iga GAES, Chavez-Pacheco SM, Tyrakis P, de Oliveira GS, Kirkman T, El Bakali J, Rocco SA, Sforça ML, Parise Filho R, Coyne AG, Blundell TL, Abell C, Dias MVB. Using a fragment-based approach to identify alternative chemical scaffolds targeting dihydrofolate reductase from Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 32603583 DOI: 10.1021/Acsinfecdis.0C00263 |
0.752 |
|
| 2020 |
Thomas SE, Whitehouse AJ, Brown K, Burbaud S, Belardinelli JM, Sangen J, Lahiri R, Libardo MDJ, Gupta P, Malhotra S, Boshoff HIM, Jackson M, Abell C, Coyne AG, Blundell TL, et al. Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification. Nucleic Acids Research. PMID 32602532 DOI: 10.1093/Nar/Gkaa539 |
0.736 |
|
| 2020 |
Sabbah M, Mendes V, Vistal RG, Dias DM, Záhorszká M, Mikušová K, Korduláková J, Coyne AG, Blundell TL, Abell C. Fragment-based design of Mycobacterium tuberculosis InhA inhibitors. Journal of Medicinal Chemistry. PMID 32240584 DOI: 10.1021/Acs.Jmedchem.0C00007 |
0.73 |
|
| 2019 |
Trapero A, Pacitto A, Chan DS, Abell C, Blundell TL, Ascher DB, Coyne AG. Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH). Bioorganic & Medicinal Chemistry Letters. 126792. PMID 31757668 DOI: 10.1016/J.Bmcl.2019.126792 |
0.803 |
|
| 2019 |
Whitehouse AJ, Libardo MDJ, Kasbekar M, Brear PD, Fischer G, Thomas CJ, Barry C, Boshoff HIM, Coyne AG, Abell C. Targeting of fumarate hydratase from Mycobacterium tuberculosis using allosteric inhibitors with a dimeric-binding mode. Journal of Medicinal Chemistry. PMID 31517489 DOI: 10.1021/Acs.Jmedchem.9B01203 |
0.691 |
|
| 2019 |
Chan DS, Hess J, Shaw E, Spry C, Starley R, Dagostin C, Dias MV, Kale R, Mendes V, Blundell TL, Coyne AG, Abell C. Structural Insights into Phosphopantothenoylcysteine Synthetase by Native Ion Mobility-Mass Spectrometry. The Biochemical Journal. PMID 31488574 DOI: 10.1042/Bcj20190318 |
0.798 |
|
| 2019 |
Whitehouse A, Thomas SE, Brown KP, Fanourakis A, Chan D, Libardo MDJ, Mendes V, Boshoff HIM, Floto RA, Abell C, Blundell TL, Coyne AG. Development of inhibitors against Mycobacterium abscessus tRNA (m1G37) methyltransferase (TrmD) using fragment-based approaches. Journal of Medicinal Chemistry. PMID 31282680 DOI: 10.1021/Acs.Jmedchem.9B00809 |
0.714 |
|
| 2019 |
Thomas SE, Collins P, James RH, Mendes V, Charoensutthivarakul S, Radoux C, Abell C, Coyne AG, Floto RA, von Delft F, Blundell TL. Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 377: 20180422. PMID 31030650 DOI: 10.1098/Rsta.2018.0422 |
0.803 |
|
| 2019 |
Bestgen B, Krimm I, Kufareva I, Kamal A, Seetoh WG, Abell C, Hartmann RW, Abagyan R, Cochet C, Le Borgne M, Engel M, Lomberget T. 2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 1: Identification of an allosteric binding site. Journal of Medicinal Chemistry. PMID 30689953 DOI: 10.1021/Acs.Jmedchem.8B01766 |
0.397 |
|
| 2019 |
Bestgen B, Kufareva I, Seetoh W, Abell C, Hartmann RW, Abagyan R, Le Borgne M, Filhol O, Cochet C, Lomberget T, Engel M. 2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 2: Structure-based optimization and investigation of effects specific to the allosteric mode of action. Journal of Medicinal Chemistry. PMID 30689946 DOI: 10.1021/Acs.Jmedchem.8B01765 |
0.391 |
|
| 2019 |
Bornemann S, Theoclitou ME, Brune M, Webb MR, Thorneley RN, Abell C. A Secondary beta Deuterium Kinetic Isotope Effect in the Chorismate Synthase Reaction. Bioorganic Chemistry. 28: 191-204. PMID 11034781 DOI: 10.1006/Bioo.2000.1174 |
0.318 |
|
| 2018 |
Trapero A, Pacitto A, Singh V, Sabbah M, Coyne AG, Mizrahi V, Blundell TL, Ascher DB, Abell C. A fragment-based approach to targeting inosine-5´-monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosis. Journal of Medicinal Chemistry. PMID 29547284 DOI: 10.1021/Acs.Jmedchem.7B01622 |
0.755 |
|
| 2017 |
Mugumbate G, Mendes V, Blaszczyk M, Sabbah M, Papadatos G, Lelievre J, Ballell L, Barros D, Abell C, Blundell TL, Overington JP. Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach. Frontiers in Pharmacology. 8: 681. PMID 29018348 DOI: 10.3389/Fphar.2017.00681 |
0.537 |
|
| 2017 |
Chan DS, Whitehouse AJ, Coyne AG, Abell C. Mass spectrometry for fragment screening. Essays in Biochemistry. PMID 28986384 DOI: 10.1042/Ebc20170071 |
0.773 |
|
| 2017 |
Chan DS, Kavanagh MEE, McLean KJ, Munro AW, Matak-Vinkovic D, Coyne AG, Abell C. Effect of DMSO on Protein Structure and Interactions Assessed By Collision-induced Dissociation and Unfolding. Analytical Chemistry. PMID 28803470 DOI: 10.1021/Acs.Analchem.7B02329 |
0.647 |
|
| 2017 |
Chan DS, Mendes V, Thomas SE, McConnell BN, Matak-Vinković D, Coyne AG, Blundell TL, Abell C. Fragment screening against the EthR-DNA interaction by native mass spectrometry. Angewandte Chemie (International Ed. in English). PMID 28513917 DOI: 10.1002/Anie.201702888 |
0.792 |
|
| 2017 |
Macaulay KM, Heath GA, Ciulli A, Murphy AM, Abell C, Carr JP, Smith AG. The biochemical properties of the two Arabidopsis thaliana isochorismate synthases. The Biochemical Journal. PMID 28356402 DOI: 10.1042/Bcj20161069 |
0.761 |
|
| 2017 |
Nikiforov PO, Blaszczyk M, Surade S, Boshoff HI, Sajid A, Delorme V, Deboosere N, Brodin P, Baulard AR, Barry Rd CE, Blundell TL, Abell C. Fragment-sized EthR inhibitors exhibit exceptionally strong ethionamide boosting effect in whole cell Mycobacterium tuberculosis assays. Acs Chemical Biology. PMID 28314097 DOI: 10.1021/Acschembio.7B00091 |
0.525 |
|
| 2017 |
Shiu-Hin Chan D, Seetoh WG, McConnell BN, Matak-Vinković D, Thomas SE, Mendes V, Blaszczyk M, Coyne AG, Blundell TL, Abell C. Structural insights into the EthR-DNA interaction using native mass spectrometry. Chemical Communications (Cambridge, England). PMID 28287239 DOI: 10.1039/C7Cc00804J |
0.701 |
|
| 2017 |
Kavanagh ME, Chenge J, Zoufir A, McLean KJ, Coyne AG, Bender A, Munro AW, Abell C. A fragment profiling approach to inhibitors of the orphan M. tuberculosis P450 CYP144A1. Biochemistry. PMID 28169518 DOI: 10.1021/Acs.Biochem.6B00954 |
0.709 |
|
| 2017 |
Ndieyira JW, Bailey J, Patil SB, Vögtli M, Cooper MA, Abell C, McKendry RA, Aeppli G. Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action. Scientific Reports. 7: 41206. PMID 28155918 DOI: 10.1038/Srep41206 |
0.3 |
|
| 2017 |
Kavanagh ME, Gray JL, Gilbert SH, Coyne AG, McLean KJ, Davis HJ, Munro AW, Abell C. Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors. Chemmedchem. 12: 194-195. PMID 28112499 DOI: 10.1002/Cmdc.201600619 |
0.661 |
|
| 2016 |
Brear P, De Fusco C, Hadje Georgiou K, Francis-Newton NJ, Stubbs CJ, Sore HF, Venkitaraman AR, Abell C, Spring DR, Hyvönen M. Specific inhibition of CK2α from an anchor outside the active site. Chemical Science. 7: 6839-6845. PMID 28451126 DOI: 10.1039/C6Sc02335E |
0.664 |
|
| 2016 |
Chenge JT, Le DV, Swami S, McLean KJ, Kavanagh ME, Coyne AG, Rigby SE, Cheesman MR, Girvan HM, Levy CW, Rupp B, von Kries JP, Abell C, Leys D, Munro AW. Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1. The Journal of Biological Chemistry. PMID 27932461 DOI: 10.1074/Jbc.M116.748822 |
0.702 |
|
| 2016 |
Marchetti C, Chan DS, Coyne AG, Abell C. Fragment-based approaches to TB drugs. Parasitology. 1-12. PMID 27804891 DOI: 10.1017/S0031182016001876 |
0.677 |
|
| 2016 |
Moschetti T, Sharpe T, Fischer G, Marsh ME, Ng H, Morgan M, Scott D, Blundell TL, Venkitaraman A, Skidmore J, Abell C, Hyvönen M. Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51. Journal of Molecular Biology. PMID 27725183 DOI: 10.1016/J.Jmb.2016.10.009 |
0.718 |
|
| 2016 |
Kavanagh ME, Gray JL, Gilbert SH, Coyne AG, McLean KJ, Davis HJ, Munro AW, Abell C. Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors. Chemmedchem. PMID 27432475 DOI: 10.1002/Cmdc.201600248 |
0.707 |
|
| 2016 |
Marsh ME, Scott DE, Ehebauer MT, Abell C, Blundell TL, Hyvönen M. ATP half-sites in RadA and RAD51 recombinases bind nucleotides. Febs Open Bio. 6: 372-85. PMID 27419043 DOI: 10.1002/2211-5463.12052 |
0.699 |
|
| 2016 |
Kasbekar M, Fischer G, Mott BT, Yasgar A, Hyvönen M, Boshoff HI, Abell C, Barry CE, Thomas CJ. Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site. Proceedings of the National Academy of Sciences of the United States of America. PMID 27325754 DOI: 10.1073/Pnas.1600630113 |
0.704 |
|
| 2016 |
Davis HJ, Kavanagh ME, Balan T, Abell C, Coyne AG. Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis. Bioorganic & Medicinal Chemistry Letters. PMID 27287372 DOI: 10.1016/J.Bmcl.2016.05.073 |
0.685 |
|
| 2016 |
Chenge J, Kavanagh ME, Driscoll MD, McLean KJ, Young DB, Cortes T, Matak-Vinkovic D, Levy CW, Rigby SE, Leys D, Abell C, Munro AW. Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis. Scientific Reports. 6: 26628. PMID 27225995 DOI: 10.1038/Srep26628 |
0.376 |
|
| 2016 |
Scott DE, Bayly AR, Abell C, Skidmore J. Small molecules, big targets: drug discovery faces the protein-protein interaction challenge. Nature Reviews. Drug Discovery. PMID 27050677 DOI: 10.1038/Nrd.2016.29 |
0.324 |
|
| 2016 |
Kavanagh ME, Coyne AG, McLean KJ, James GG, Levy CW, Marino LB, de Carvalho LP, Chan DS, Hudson SA, Surade S, Leys D, Munro AW, Abell C. Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. Journal of Medicinal Chemistry. 59: 3272-302. PMID 27002486 DOI: 10.1021/Acs.Jmedchem.6B00007 |
0.707 |
|
| 2016 |
Seetoh WG, Chan DS, Matak-Vinković D, Abell C. Mass Spectrometry Reveals Protein Kinase CK2 High-Order Oligomerization via the Circular and Linear Assembly. Acs Chemical Biology. 11: 1511-7. PMID 26999075 DOI: 10.1021/Acschembio.6B00064 |
0.637 |
|
| 2016 |
Scott DE, Marsh M, Blundell TL, Abell C, Hyvönen M. Structure Activity Relationship of the Peptide Binding Motif Mediating the RAD51:BRCA2 Protein-Protein Interaction. Febs Letters. PMID 26992456 DOI: 10.1002/1873-3468.12139 |
0.688 |
|
| 2016 |
Nikiforov PO, Surade S, Blaszczyk M, Delorme V, Brodin P, Baulard AR, Blundell TL, Abell C. A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters. Organic & Biomolecular Chemistry. PMID 26806381 DOI: 10.1039/C5Ob02630J |
0.548 |
|
| 2016 |
Chaikuad A, Lang S, Brennan PE, Temperini C, Fedorov O, Hollander J, Nachane R, Abell C, Müller S, Siegal G, Knapp S. Structure-based identification of inhibitory fragments targeting the p300/CBP-associated factor bromodomain. Journal of Medicinal Chemistry. PMID 26731131 DOI: 10.1021/Acs.Jmedchem.5B01719 |
0.377 |
|
| 2016 |
Chenge JT, Le DV, Swami S, McLean KJ, Kavanagh ME, Coyne A, Rigby SJE, Cheesman MYR, Girvan HM, Levy CW, Rupp B, Kries JPv, Abell C, Leys D, Munro A. Crystal structure of Mycobacterium tuberculosis CYP126A1 in complex with 1-(3-(1H-imidazol-1-yl)propyl)-3-((3s,5s,7s)-adamantan-1-yl)urea Journal of Biological Chemistry. DOI: 10.2210/Pdb5Li7/Pdb |
0.633 |
|
| 2016 |
Chan DS, Matak-Vinković D, Coyne AG, Abell C. Insight into Protein Conformation and Subcharging by DMSO from Native Ion Mobility Mass Spectrometry Chemistryselect. 1: 5686-5690. DOI: 10.1002/slct.201601402 |
0.593 |
|
| 2015 |
Tan YS, Spring DR, Abell C, Verma CS. The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein-Protein Interactions. Journal of Chemical Theory and Computation. 11: 3199-3210. PMID 26575757 DOI: 10.1021/Ct5010577 |
0.313 |
|
| 2015 |
Hung AW, Silvestre HL, Wen S, George GP, Boland J, Blundell TL, Ciulli A, Abell C. Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis. Chemmedchem. PMID 26486566 DOI: 10.1002/Cmdc.201500414 |
0.803 |
|
| 2015 |
Holvey RS, Valkov E, Neal D, Stewart M, Abell C. Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design. Chemmedchem. 10: 1232-9. PMID 25899172 DOI: 10.1002/Cmdc.201500014 |
0.358 |
|
| 2015 |
Scott DE, Coyne AG, Venkitaraman A, Blundell TL, Abell C, Hyvönen M. Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases. Chemmedchem. 10: 296-303. PMID 25470112 DOI: 10.1002/Cmdc.201402428 |
0.803 |
|
| 2015 |
Howard NI, Dias MV, Peyrot F, Chen L, Schmidt MF, Blundell TL, Abell C. Design and structural analysis of aromatic inhibitors of type II dehydroquinase from Mycobacterium tuberculosis. Chemmedchem. 10: 116-33. PMID 25234229 DOI: 10.1002/Cmdc.201402298 |
0.548 |
|
| 2014 |
Ferguson FM, Dias DM, Rodrigues JP, Wienk H, Boelens R, Bonvin AM, Abell C, Ciulli A. Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking. Biochemistry. 53: 6706-16. PMID 25266743 DOI: 10.1021/Bi500909D |
0.786 |
|
| 2014 |
Fischlechner M, Schaerli Y, Mohamed MF, Patil S, Abell C, Hollfelder F. Evolution of enzyme catalysts caged in biomimetic gel-shell beads. Nature Chemistry. 6: 791-6. PMID 25143214 DOI: 10.1038/Nchem.1996 |
0.326 |
|
| 2014 |
Mageed SN, Cunningham F, Hung AW, Silvestre HL, Wen S, Blundell TL, Abell C, McConkey GA. Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy. Antimicrobial Agents and Chemotherapy. 58: 6345-53. PMID 25049241 DOI: 10.1128/Aac.02640-14 |
0.487 |
|
| 2014 |
Srinivasan R, Coyne AG, Abell C. Regioselective conversion of arenes to N-aryl-1,2,3-triazoles using C-H borylation. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 11680-4. PMID 25048717 DOI: 10.1002/Chem.201403021 |
0.77 |
|
| 2014 |
Tan YS, Spring DR, Abell C, Verma C. The use of chlorobenzene as a probe molecule in molecular dynamics simulations. Journal of Chemical Information and Modeling. 54: 1821-7. PMID 24910248 DOI: 10.1021/Ci500215X |
0.323 |
|
| 2014 |
Warner KD, Homan P, Weeks KM, Smith AG, Abell C, Ferré-D'Amaré AR. Validating fragment-based drug discovery for biological RNAs: lead fragments bind and remodel the TPP riboswitch specifically. Chemistry & Biology. 21: 591-5. PMID 24768306 DOI: 10.1016/J.Chembiol.2014.03.007 |
0.386 |
|
| 2014 |
Webb ME, Yorke BA, Kershaw T, Lovelock S, Lobley CM, Kilkenny ML, Smith AG, Blundell TL, Pearson AR, Abell C. Threonine 57 is required for the post-translational activation of Escherichia coli aspartate α-decarboxylase. Acta Crystallographica. Section D, Biological Crystallography. 70: 1166-72. PMID 24699660 DOI: 10.1107/S1399004713034275 |
0.785 |
|
| 2014 |
Hudson SA, Mashalidis EH, Bender A, McLean KJ, Munro AW, Abell C. Biofragments: an approach towards predicting protein function using biologically related fragments and its application to Mycobacterium tuberculosis CYP126. Chembiochem : a European Journal of Chemical Biology. 15: 549-55. PMID 24677424 DOI: 10.1002/Cbic.201300697 |
0.419 |
|
| 2014 |
Nasiri HR, Bell NM, McLuckie KI, Husby J, Abell C, Neidle S, Balasubramanian S. Targeting a c-MYC G-quadruplex DNA with a fragment library. Chemical Communications (Cambridge, England). 50: 1704-7. PMID 24394582 DOI: 10.1039/C3Cc48390H |
0.486 |
|
| 2014 |
Surade S, Ty N, Hengrung N, Lechartier B, Cole ST, Abell C, Blundell TL. A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR. The Biochemical Journal. 458: 387-94. PMID 24313835 DOI: 10.1042/Bj20131127 |
0.537 |
|
| 2013 |
Ferguson FM, Fedorov O, Chaikuad A, Philpott M, Muniz JR, Felletar I, von Delft F, Heightman T, Knapp S, Abell C, Ciulli A. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. Journal of Medicinal Chemistry. 56: 10183-7. PMID 24304323 DOI: 10.1021/Jm401582C |
0.788 |
|
| 2013 |
Mashalidis EH, ?led? P, Lang S, Abell C. A three-stage biophysical screening cascade for fragment-based drug discovery. Nature Protocols. 8: 2309-24. PMID 24157549 DOI: 10.1038/Nprot.2013.130 |
0.37 |
|
| 2013 |
Schmidt MF, Korb O, Abell C. MicroRNA-specific argonaute 2 protein inhibitors. Acs Chemical Biology. 8: 2122-6. PMID 23902134 DOI: 10.1021/Cb400246K |
0.364 |
|
| 2013 |
Silvestre HL, Blundell TL, Abell C, Ciulli A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proceedings of the National Academy of Sciences of the United States of America. 110: 12984-9. PMID 23872845 DOI: 10.1073/Pnas.1304045110 |
0.805 |
|
| 2013 |
Shim JU, Ranasinghe RT, Smith CA, Ibrahim SM, Hollfelder F, Huck WT, Klenerman D, Abell C. Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays. Acs Nano. 7: 5955-64. PMID 23805985 DOI: 10.1021/Nn401661D |
0.317 |
|
| 2013 |
Hudson SA, Surade S, Coyne AG, McLean KJ, Leys D, Munro AW, Abell C. Overcoming the limitations of fragment merging: rescuing a strained merged fragment series targeting Mycobacterium tuberculosis CYP121. Chemmedchem. 8: 1451-6. PMID 23788280 DOI: 10.1002/Cmdc.201300219 |
0.646 |
|
| 2013 |
Duffell KM, Hudson SA, McLean KJ, Munro AW, Abell C, Matak-Vinkovi? D. Nanoelectrospray ionization mass spectrometric study of Mycobacterium tuberculosis CYP121-ligand interactions. Analytical Chemistry. 85: 5707-14. PMID 23675886 DOI: 10.1021/Ac400236Z |
0.354 |
|
| 2013 |
Smith CA, Li X, Mize TH, Sharpe TD, Graziani EI, Abell C, Huck WT. Sensitive, high throughput detection of proteins in individual, surfactant-stabilized picoliter droplets using nanoelectrospray ionization mass spectrometry. Analytical Chemistry. 85: 3812-6. PMID 23514243 DOI: 10.1021/Ac400453T |
0.3 |
|
| 2013 |
Scott DE, Ehebauer MT, Pukala T, Marsh M, Blundell TL, Venkitaraman AR, Abell C, Hyvönen M. Using a fragment-based approach to target protein-protein interactions. Chembiochem : a European Journal of Chemical Biology. 14: 332-42. PMID 23344974 DOI: 10.1002/Cbic.201200521 |
0.728 |
|
| 2013 |
Schmidt MF, Korb O, Howard NI, Dias MV, Blundell TL, Abell C. Discovery of Schaeffer's acid analogues as lead structures of mycobacterium tuberculosis type II dehydroquinase using a rational drug design approach. Chemmedchem. 8: 54-8. PMID 23169689 DOI: 10.1002/Cmdc.201200508 |
0.537 |
|
| 2013 |
Ryan A, Eleftheriadou O, Halman A, Sieg C, Keany S, Ciulli A, Abell C, Lowe ED, Sim E. Fragment-based approaches for anti-tuberculosis drug discovery Acta Crystallographica Section a Foundations of Crystallography. 69: s349-s349. DOI: 10.1107/S0108767313096992 |
0.772 |
|
| 2012 |
Tan YS, ?led? P, Lang S, Stubbs CJ, Spring DR, Abell C, Best RB. Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1. Angewandte Chemie (International Ed. in English). 51: 10078-81. PMID 22961729 DOI: 10.1002/Anie.201205676 |
0.334 |
|
| 2012 |
Ballester PJ, Mangold M, Howard NI, Robinson RL, Abell C, Blumberger J, Mitchell JB. Hierarchical virtual screening for the discovery of new molecular scaffolds in antibacterial hit identification. Journal of the Royal Society, Interface / the Royal Society. 9: 3196-207. PMID 22933186 DOI: 10.1098/Rsif.2012.0569 |
0.35 |
|
| 2012 |
Hudson SA, McLean KJ, Surade S, Yang YQ, Leys D, Ciulli A, Munro AW, Abell C. Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121. Angewandte Chemie (International Ed. in English). 51: 9311-6. PMID 22890978 DOI: 10.1002/Anie.201202544 |
0.78 |
|
| 2012 |
Abrahams GL, Kumar A, Savvi S, Hung AW, Wen S, Abell C, Barry CE, Sherman DR, Boshoff HI, Mizrahi V. Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening. Chemistry & Biology. 19: 844-54. PMID 22840772 DOI: 10.1016/J.Chembiol.2012.05.020 |
0.347 |
|
| 2012 |
?led? P, Lang S, Stubbs CJ, Abell C. High-throughput interrogation of ligand binding mode using a fluorescence-based assay. Angewandte Chemie (International Ed. in English). 51: 7680-3. PMID 22730171 DOI: 10.1002/Anie.201202660 |
0.317 |
|
| 2012 |
Scott DE, Coyne AG, Hudson SA, Abell C. Fragment-based approaches in drug discovery and chemical biology. Biochemistry. 51: 4990-5003. PMID 22697260 DOI: 10.1021/Bi3005126 |
0.689 |
|
| 2012 |
Hudson SA, McLean KJ, Munro AW, Abell C. Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets. Biochemical Society Transactions. 40: 573-9. PMID 22616869 DOI: 10.1042/Bst20120062 |
0.335 |
|
| 2012 |
Chen L, Cressina E, Dixon N, Erixon K, Agyei-Owusu K, Micklefield J, Smith AG, Abell C, Leeper FJ. Probing riboswitch-ligand interactions using thiamine pyrophosphate analogues. Organic & Biomolecular Chemistry. 10: 5924-31. PMID 22514012 DOI: 10.1039/C2Ob07116A |
0.326 |
|
| 2012 |
Webb ME, Lobley CM, Soliman F, Kilkenny ML, Smith AG, Blundell TL, Abell C. Structure of Escherichia coli aspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 414-7. PMID 22505409 DOI: 10.1107/S1744309112009487 |
0.632 |
|
| 2012 |
Śledź P, Abell C, Ciulli A. Ligand-Observed NMR in Fragment-Based Approaches Nmr of Biomolecules: Towards Mechanistic Systems Biology. 264-280. DOI: 10.1002/9783527644506.ch15 |
0.753 |
|
| 2011 |
Mashalidis EH, Mukherjee T, Sledź P, Matak-Vinković D, Boshoff H, Abell C, Barry CE. Rv2607 from Mycobacterium tuberculosis is a pyridoxine 5'-phosphate oxidase with unusual substrate specificity. Plos One. 6: e27643. PMID 22110704 DOI: 10.1371/Journal.Pone.0027643 |
0.333 |
|
| 2011 |
?led? P, Stubbs CJ, Lang S, Yang YQ, McKenzie GJ, Venkitaraman AR, Hyvönen M, Abell C. From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1. Angewandte Chemie (International Ed. in English). 50: 4003-6. PMID 21472932 DOI: 10.1002/Anie.201008019 |
0.663 |
|
| 2011 |
Cressina E, Chen L, Moulin M, Leeper FJ, Abell C, Smith AG. Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches. Biochemical Society Transactions. 39: 652-7. PMID 21428956 DOI: 10.1042/Bst0390652 |
0.362 |
|
| 2011 |
Dias MV, Snee WC, Bromfield KM, Payne RJ, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. The Biochemical Journal. 436: 729-39. PMID 21410435 DOI: 10.1042/Bj20110002 |
0.818 |
|
| 2011 |
Zhou D, Li Y, Hall EA, Abell C, Klenerman D. A chelating dendritic ligand capped quantum dot: preparation, surface passivation, bioconjugation and specific DNA detection. Nanoscale. 3: 201-11. PMID 21046040 DOI: 10.1039/C0Nr00462F |
0.557 |
|
| 2011 |
Sledz P, Lang S, Stubbs C, Hyvonen M, Abell C. Surface flexibility of Plk1 – implications in substrate binding and drug design Acta Crystallographica Section A. 67: 550-550. DOI: 10.1107/S0108767311086090 |
0.317 |
|
| 2011 |
Cressina E, Chen L, Abell C, Leeper FJ, Smith AG. Fragment screening against the thiamine pyrophosphate riboswitch thiM Chemical Science. 2: 157-165. DOI: 10.1039/C0Sc00406E |
0.35 |
|
| 2011 |
Wu N, Courtois F, Surjadi R, Oakeshott J, Peat TS, Easton CJ, Abell C, Zhu Y. Enzyme synthesis and activity assay in microfluidic droplets on a chip Engineering in Life Sciences. 11: 157-164. DOI: 10.1002/Elsc.201000043 |
0.348 |
|
| 2010 |
Schaerli Y, Stein V, Spiering MM, Benkovic SJ, Abell C, Hollfelder F. Isothermal DNA amplification using the T4 replisome: circular nicking endonuclease-dependent amplification and primase-based whole-genome amplification. Nucleic Acids Research. 38: e201. PMID 20921065 DOI: 10.1093/Nar/Gkq795 |
0.43 |
|
| 2010 |
Holt DJ, Payne RJ, Chow WY, Abell C. Fluorosurfactants for microdroplets: interfacial tension analysis. Journal of Colloid and Interface Science. 350: 205-11. PMID 20638074 DOI: 10.1016/J.Jcis.2010.06.036 |
0.654 |
|
| 2010 |
Payne RJ, Bulloch EM, Kerbarh O, Abell C. Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues. Organic & Biomolecular Chemistry. 8: 3534-42. PMID 20532401 DOI: 10.1039/C004062B |
0.51 |
|
| 2010 |
Sledz P, Silvestre HL, Hung AW, Ciulli A, Blundell TL, Abell C. Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. Journal of the American Chemical Society. 132: 4544-5. PMID 20232910 DOI: 10.1021/Ja100595U |
0.82 |
|
| 2010 |
Coyne AG, Scott DE, Abell C. Drugging challenging targets using fragment-based approaches. Current Opinion in Chemical Biology. 14: 299-307. PMID 20223699 DOI: 10.1016/J.Cbpa.2010.02.010 |
0.676 |
|
| 2010 |
Batchelor M, Zhou D, Cooper MA, Abell C, Rayment T. Vancomycin dimer formation between analogues of bacterial peptidoglycan surfaces probed by force spectroscopy. Organic & Biomolecular Chemistry. 8: 1142-8. PMID 20165806 DOI: 10.1039/B919347B |
0.562 |
|
| 2010 |
Chen L, Cressina E, Leeper FJ, Smith AG, Abell C. A fragment-based approach to identifying ligands for riboswitches. Acs Chemical Biology. 5: 355-8. PMID 20158266 DOI: 10.1021/Cb9003139 |
0.343 |
|
| 2010 |
Sridharan S, Howard N, Kerbarh O, B?aszczyk M, Abell C, Blundell TL. Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes. Journal of Molecular Biology. 397: 290-300. PMID 20079748 DOI: 10.1016/J.Jmb.2010.01.019 |
0.513 |
|
| 2010 |
Holt DJ, Payne RJ, Abell C. Synthesis of novel fluorous surfactants for microdroplet stabilisation in fluorous oil streams Journal of Fluorine Chemistry. 131: 398-407. DOI: 10.1016/J.Jfluchem.2009.12.010 |
0.454 |
|
| 2009 |
Scott DE, Dawes GJ, Ando M, Abell C, Ciulli A. A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry. Chembiochem : a European Journal of Chemical Biology. 10: 2772-9. PMID 19827080 DOI: 10.1002/Cbic.200900537 |
0.81 |
|
| 2009 |
Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C. Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. Angewandte Chemie (International Ed. in English). 48: 8452-6. PMID 19780086 DOI: 10.1002/Anie.200903821 |
0.801 |
|
| 2009 |
Payne RJ, Bulloch EM, Toscano MM, Jones MA, Kerbarh O, Abell C. Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes. Organic & Biomolecular Chemistry. 7: 2421-9. PMID 19462053 DOI: 10.1039/B901694E |
0.523 |
|
| 2009 |
Fidalgo LM, Whyte G, Ruotolo BT, Benesch JL, Stengel F, Abell C, Robinson CV, Huck WT. Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online. Angewandte Chemie (International Ed. in English). 48: 3665-8. PMID 19353614 DOI: 10.1002/Anie.200806103 |
0.306 |
|
| 2009 |
Sinniah K, Porter-Peden L, Byker S, Blankespoor R, Zhou D, Abell C, Rayment T. A Single Molecule Study of Enzyme Inhibitor Interactions Biophysical Journal. 96: 643a. DOI: 10.1016/J.Bpj.2008.12.3403 |
0.585 |
|
| 2009 |
Heikkila TJ, Surade S, Silvestre HL, Dias MVB, Ciulli A, Bromfield K, Scott D, Howard N, Wen S, Wei AH, Osborne D, Abell C, Blundell TL. Fragment-based drug discovery in academia: Experiences from a tuberculosis programme Nato Science For Peace and Security Series a: Chemistry and Biology. 21-36. DOI: 10.1007/978-90-481-2339-1-3 |
0.409 |
|
| 2009 |
Scott DE, Dawes GJ, Ando M, Abell C, Ciulli A. Inside Cover: A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry (ChemBioChem 17/2009) Chembiochem. 10: 2678-2678. DOI: 10.1002/Cbic.200990077 |
0.764 |
|
| 2009 |
Heikkila TJ, Surade S, Silvestre HL, Dias MVB, Ciulli A, Bromfield K, Scott D, Howard N, Wen S, Wei AH, Osborne D, Abell C, Blundell TL. Fragment-based drug discovery in academia: Experiences from a tuberculosis programme Nato Science For Peace and Security Series a: Chemistry and Biology. 21-36. |
0.409 |
|
| 2008 |
Ndieyira JW, Watari M, Barrera AD, Zhou D, Vögtli M, Batchelor M, Cooper MA, Strunz T, Horton MA, Abell C, Rayment T, Aeppli G, McKendry RA. Nanomechanical detection of antibiotic-mucopeptide binding in a model for superbug drug resistance. Nature Nanotechnology. 3: 691-6. PMID 18989336 DOI: 10.1038/Nnano.2008.275 |
0.577 |
|
| 2008 |
Ciulli A, Scott DE, Ando M, Reyes F, Saldanha SA, Tuck KL, Chirgadze DY, Blundell TL, Abell C. Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate. Chembiochem : a European Journal of Chemical Biology. 9: 2606-11. PMID 18821554 DOI: 10.1002/Cbic.200800437 |
0.806 |
|
| 2008 |
Huebner A, Olguin LF, Bratton D, Whyte G, Huck WT, de Mello AJ, Edel JB, Abell C, Hollfelder F. Development of quantitative cell-based enzyme assays in microdroplets. Analytical Chemistry. 80: 3890-6. PMID 18399662 DOI: 10.1021/Ac800338Z |
0.328 |
|
| 2008 |
Zhou D, Ying L, Hong X, Hall EA, Abell C, Klenerman D. A compact functional quantum Dot-DNA conjugate: preparation, hybridization, and specific label-free DNA detection. Langmuir : the Acs Journal of Surfaces and Colloids. 24: 1659-64. PMID 18193909 DOI: 10.1021/La703583U |
0.547 |
|
| 2007 |
Kamper SG, Porter-Peden L, Blankespoor R, Sinniah K, Zhou D, Abell C, Rayment T. Investigating the specific interactions between carbonic anhydrase and a sulfonamide inhibitor by single-molecule force spectroscopy. Langmuir : the Acs Journal of Surfaces and Colloids. 23: 12561-5. PMID 17973506 DOI: 10.1021/La702148V |
0.609 |
|
| 2007 |
Ciulli A, Abell C. Fragment-based approaches to enzyme inhibition. Current Opinion in Biotechnology. 18: 489-96. PMID 17959370 DOI: 10.1016/J.Copbio.2007.09.003 |
0.794 |
|
| 2007 |
Scott DE, Ciulli A, Abell C. Coenzyme biosynthesis: enzyme mechanism, structure and inhibition. Natural Product Reports. 24: 1009-26. PMID 17898895 DOI: 10.1039/B703108B |
0.787 |
|
| 2007 |
Payne RJ, Riboldi-Tunnicliffe A, Kerbarh O, Abell AD, Lapthorn AJ, Abell C. Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases. Chemmedchem. 2: 1010-3. PMID 17487901 DOI: 10.1002/Cmdc.200700062 |
0.527 |
|
| 2007 |
Payne RJ, Peyrot F, Kerbarh O, Abell AD, Abell C. Rational design, synthesis, and evaluation of nanomolar type II dehydroquinase inhibitors. Chemmedchem. 2: 1015-29. PMID 17487900 DOI: 10.1002/Cmdc.200700032 |
0.523 |
|
| 2007 |
Kerbarh O, Ciulli A, Chirgadze DY, Blundell TL, Abell C. Nucleophile selectivity of chorismate-utilizing enzymes. Chembiochem : a European Journal of Chemical Biology. 8: 622-4. PMID 17335098 DOI: 10.1002/Cbic.200700019 |
0.797 |
|
| 2007 |
Ciulli A, Lobley CM, Tuck KL, Smith AG, Blundell TL, Abell C. pH-tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study. Acta Crystallographica. Section D, Biological Crystallography. 63: 171-8. PMID 17242510 DOI: 10.1107/S0907444906044465 |
0.797 |
|
| 2007 |
Ciulli A, Chirgadze DY, Smith AG, Blundell TL, Abell C. Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: Substrate recognition, conformational change, and cooperativity Journal of Biological Chemistry. 282: 8487-8497. PMID 17229734 DOI: 10.1074/Jbc.M611171200 |
0.805 |
|
| 2007 |
Toscano MD, Payne RJ, Chiba A, Kerbarh O, Abell C. Nanomolar inhibition of type II dehydroquinase based on the enolate reaction mechanism. Chemmedchem. 2: 101-12. PMID 17068841 DOI: 10.1002/Cmdc.200600194 |
0.515 |
|
| 2007 |
Ciulli A, Blundell TL, Abell C. Discovery and extrapolation of fragment structures towards drug design Rsc Biomolecular Sciences. 293-318. |
0.4 |
|
| 2006 |
Tuck KL, Saldanha SA, Birch LM, Smith AG, Abell C. The design and synthesis of inhibitors of pantothenate synthetase. Organic & Biomolecular Chemistry. 4: 3598-610. PMID 16990935 DOI: 10.1039/B609482A |
0.644 |
|
| 2006 |
Ciulli A, Williams G, Smith AG, Blundell TL, Abell C. Probing hot spots at protein-ligand binding sites: A fragment-based approach using biophysical methods Journal of Medicinal Chemistry. 49: 4992-5000. PMID 16884311 DOI: 10.1021/Jm060490R |
0.805 |
|
| 2006 |
Rauf S, Zhou D, Abell C, Klenerman D, Kang DJ. Building three-dimensional nanostructures with active enzymes by surface templated layer-by-layer assembly. Chemical Communications (Cambridge, England). 1721-3. PMID 16609783 DOI: 10.1039/B517557G |
0.546 |
|
| 2006 |
Manzanera M, Frankel DJ, Li H, Zhou D, Bruckbauer A, Kreutzmann P, Blackburn JM, Abell C, Rayment T, Klenerman D, Barker PD. Macroscopic 2D networks self-assembled from nanometer-sized protein/DNA complexes. Nano Letters. 6: 365-70. PMID 16522024 DOI: 10.1021/Nl051599+ |
0.555 |
|
| 2006 |
Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. Journal of Medicinal Chemistry. 49: 1346-55. PMID 16480269 DOI: 10.1021/Jm050850V |
0.416 |
|
| 2006 |
Liu D, Bruckbauer A, Abell C, Balasubramanian S, Kang DJ, Klenerman D, Zhou D. A reversible pH-driven DNA nanoswitch array. Journal of the American Chemical Society. 128: 2067-71. PMID 16464109 DOI: 10.1021/Ja0568300 |
0.682 |
|
| 2006 |
Kerbarh O, Chirgadze DY, Blundell TL, Abell C. Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate Journal of Molecular Biology. 357: 524-534. PMID 16434053 DOI: 10.1016/J.Jmb.2005.12.078 |
0.522 |
|
| 2006 |
Wang X, Zhou D, Sinniah K, Clarke C, Birch L, Li H, Rayment T, Abell C. Electrostatic orientation of enzymes on surfaces for ligand screening probed by force spectroscopy. Langmuir : the Acs Journal of Surfaces and Colloids. 22: 887-92. PMID 16430243 DOI: 10.1021/La0525731 |
0.595 |
|
| 2006 |
Chakauya E, Coxon KM, Whitney HM, Ashurst JL, Abell C, Smith AG. Pantothenate biosynthesis in higher plants: Advances and challenges Physiologia Plantarum. 126: 319-329. DOI: 10.1111/J.1399-3054.2006.00683.X |
0.304 |
|
| 2005 |
Payne RJ, Bulloch EM, Abell AD, Abell C. Design and synthesis of aromatic inhibitors of anthranilate synthase. Organic & Biomolecular Chemistry. 3: 3629-35. PMID 16211099 DOI: 10.1039/b510633h |
0.439 |
|
| 2005 |
Zhou D, Piper JD, Abell C, Klenerman D, Kang DJ, Ying L. Fluorescence resonance energy transfer between a quantum dot donor and a dye acceptor attached to DNA. Chemical Communications (Cambridge, England). 4807-9. PMID 16193121 DOI: 10.1039/B508911E |
0.54 |
|
| 2005 |
Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C. Rational design of new bifunctional inhibitors of type II dehydroquinase Organic and Biomolecular Chemistry. 3: 3102-3104. PMID 16106291 DOI: 10.1039/B507156A |
0.338 |
|
| 2005 |
Ciulli A, Abell C. Biophysical tools to monitor enzyme-ligand interactions of enzymes involved in vitamin biosynthesis. Biochemical Society Transactions. 33: 767-71. PMID 16042595 DOI: 10.1042/Bst0330767 |
0.79 |
|
| 2005 |
Kerbarh O, Bulloch EM, Payne RJ, Sahr T, Rébeillé F, Abell C. Mechanistic and inhibition studies of chorismate-utilizing enzymes. Biochemical Society Transactions. 33: 763-6. PMID 16042594 DOI: 10.1042/Bst0330763 |
0.531 |
|
| 2005 |
Kerbarh O, Ciulli A, Howard NI, Abell C. Salicylate biosynthesis: overexpression, purification, and characterization of Irp9, a bifunctional salicylate synthase from Yersinia enterocolitica. Journal of Bacteriology. 187: 5061-6. PMID 16030197 DOI: 10.1128/Jb.187.15.5061-5066.2005 |
0.782 |
|
| 2005 |
Payne RJ, Toscano MD, Bulloch EM, Abell AD, Abell C. Design and synthesis of aromatic inhibitors of anthranilate synthase. Organic & Biomolecular Chemistry. 3: 2271-81. PMID 16010361 DOI: 10.1039/B503802B |
0.508 |
|
| 2005 |
Lobley CM, Ciulli A, Whitney HM, Williams G, Smith AG, Abell C, Blundell TL. The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound. Biochemistry. 44: 8930-9. PMID 15966718 DOI: 10.1021/Bi0502036 |
0.805 |
|
| 2005 |
Payne RJ, Kerbarh O, Miguel RN, Abell AD, Abell C. Inhibition studies on salicylate synthase. Organic & Biomolecular Chemistry. 3: 1825-7. PMID 15889161 DOI: 10.1039/B503800F |
0.471 |
|
| 2005 |
Webb ME, Smith AG, Abell C. Biosynthesis of Pantothenate Cheminform. 36. DOI: 10.1002/chin.200514279 |
0.474 |
|
| 2005 |
Zhou D, Bruckbauer A, Abell C, Klenerman D, Kang DJ. Fabrication of three-dimensional surface structures with highly fluorescent quantum dots by surface-templated layer-by-layer assembly Advanced Materials. 17: 1243-1248. DOI: 10.1002/Adma.200401520 |
0.529 |
|
| 2004 |
Webb ME, Smith AG, Abell C. Biosynthesis of pantothenate. Natural Product Reports. 21: 695-721. PMID 15565250 DOI: 10.1039/B316419P |
0.503 |
|
| 2004 |
Zhou D, Bruckbauer A, Batchelor M, Kang DJ, Abell C, Klenerman D. Influence of the foundation layer on the layer-by-layer assembly of poly-L-lysine and poly(styrenesulfonate) and its usage in the fabrication of 3D microscale features. Langmuir : the Acs Journal of Surfaces and Colloids. 20: 9089-94. PMID 15461491 DOI: 10.1021/La048619S |
0.48 |
|
| 2004 |
Bulloch EM, Jones MA, Parker EJ, Osborne AP, Stephens E, Davies GM, Coggins JR, Abell C. Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the antimicrobial action of (6s)-6-fluoroshikimate. Journal of the American Chemical Society. 126: 9912-3. PMID 15303852 DOI: 10.1021/Ja048312F |
0.572 |
|
| 2004 |
Frederickson M, Roszak AW, Coggins JR, Lapthorn AJ, Abell C. (1R,4S,5R)-3-fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: The fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases Organic and Biomolecular Chemistry. 2: 1592-1596. PMID 15162210 DOI: 10.1039/B404535A |
0.302 |
|
| 2004 |
Bruckbauer A, Zhou D, Kang DJ, Korchev YE, Abell C, Klenerman D. An addressable antibody nanoarray produced on a nanostructured surface. Journal of the American Chemical Society. 126: 6508-9. PMID 15161251 DOI: 10.1021/Ja0317426 |
0.54 |
|
| 2004 |
Ottenhof HH, Ashurst JL, Whitney HM, Saldanha SA, Schmitzberger F, Gweon HS, Blundell TL, Abell C, Smith AG. Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. The Plant Journal : For Cell and Molecular Biology. 37: 61-72. PMID 14675432 DOI: 10.1046/J.1365-313X.2003.01940.X |
0.488 |
|
| 2004 |
González-Bello C, Lence E, Toscano MD, Castedo L, Coggins JR, Abell C. Parallel solid-phase synthesis and evaluation of inhibitors of Streptomyces coelicolor type II dehydroquinase. Journal of Medicinal Chemistry. 46: 5735-44. PMID 14667226 DOI: 10.1021/Jm030987Q |
0.336 |
|
| 2004 |
Routledge A, Abell C, Balasubramanian S. An Investigation into Solid-Phase Radical Chemistry - Synthesis of Furan Rings Synlett. 1: 61-62. DOI: 10.1055/S-1997-704 |
0.677 |
|
| 2003 |
Webb ME, Stephens E, Smith AG, Abell C. Rapid screening by MALDI-TOF mass spectrometry to probe binding specificity at enzyme active sites. Chemical Communications (Cambridge, England). 2416-7. PMID 14587709 DOI: 10.1039/B308182F |
0.6 |
|
| 2003 |
Frederickson M, Parker EJ, Coggins JR, Abell C. Enzymic synthesis of 3-[3- 13C]dehydroquinic acid. Organic & Biomolecular Chemistry. 1: 3271-3. PMID 14584789 DOI: 10.1039/B309666A |
0.567 |
|
| 2003 |
Zhou D, Sinniah K, Abell C, Rayment T. Label-free detection of DNA hybridization at the nanoscale: a highly sensitive and selective approach using atomic-force microscopy. Angewandte Chemie (International Ed. in English). 42: 4934-7. PMID 14579443 DOI: 10.1002/Anie.200352178 |
0.548 |
|
| 2003 |
Toscano MD, Frederickson M, Evans DP, Coggins JR, Abell C, González-Bello C. Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase. Organic & Biomolecular Chemistry. 1: 2075-83. PMID 12945898 DOI: 10.1039/B301731A |
0.353 |
|
| 2003 |
Von Delft F, Inoue T, Saldanha SA, Ottenhof HH, Schmitzberger F, Birch LM, Dhanaraj V, Witty M, Smith AG, Blundell TL, Abell C. Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites Structure. 11: 985-996. PMID 12906829 DOI: 10.1016/S0969-2126(03)00158-8 |
0.514 |
|
| 2003 |
Bruckbauer A, Zhou D, Ying L, Korchev YE, Abell C, Klenerman D. Multicomponent submicron features of biomolecules created by voltage controlled deposition from a nanopipet. Journal of the American Chemical Society. 125: 9834-9. PMID 12904050 DOI: 10.1021/Ja035755V |
0.552 |
|
| 2003 |
Schmitzberger F, Smith AG, Abell C, Blundell TL. Comparative analysis of the Escherichia coli ketopantoate hydroxymethyltransferase crystal structure confirms that it is a member of the (βα)8 phosphoenolpyruvate/pyruvate superfamily Journal of Bacteriology. 185: 4163-4171. PMID 12837791 DOI: 10.1128/Jb.185.14.4163-4171.2003 |
0.51 |
|
| 2003 |
Lobley CM, Schmitzberger F, Kilkenny ML, Whitney H, Ottenhof HH, Chakauya E, Webb ME, Birch LM, Tuck KL, Abell C, Smith AG, Blundell TL. Structural insights into the evolution of the pantothenate-biosynthesis pathway. Biochemical Society Transactions. 31: 563-71. PMID 12773157 DOI: 10.1042/Bst0310563 |
0.747 |
|
| 2003 |
Coggins JR, Abell C, Evans LB, Frederickson M, Robinson DA, Roszak AW, Lapthorn AP. Experiences with the shikimate-pathway enzymes as targets for rational drug design. Biochemical Society Transactions. 31: 548-52. PMID 12773154 DOI: 10.1042/Bst0310548 |
0.341 |
|
| 2003 |
Wang X, Zhou D, Rayment T, Abell C. Systematic manipulation of surface chemical reaction on the nanoscale: a novel approach for constructing three-dimensional nanostructures. Chemical Communications (Cambridge, England). 474-5. PMID 12638956 DOI: 10.1039/B211906D |
0.564 |
|
| 2003 |
Frederickson M, Parker EJ, Coggins JR, Abell C. Enzymic synthesis of 3-[3-13C]dehydroquinic acid Organic and Biomolecular Chemistry. 1: 3271-3273. DOI: 10.1039/b309666a |
0.508 |
|
| 2003 |
Zhou D, Wang X, Birch L, Rayment T, Abell C. AFM study on protein immobilization on charged surfaces at the nanoscale: Toward the fabrication of three-dimensional protein nanostructures Langmuir. 19: 10557-10562. DOI: 10.1021/La035491Q |
0.549 |
|
| 2002 |
Todd MH, Abell C. The use of FTICR-MS to detect chemical tags from a combinatorial library. The Analyst. 127: 1399-406. PMID 12475024 DOI: 10.1039/B203957P |
0.554 |
|
| 2002 |
Saldanha SA, Birch LM, Webb ME, Nabbs BK, von Delft F, Smith AG, Abell C. Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction. Chemical Communications (Cambridge, England). 1760-1. PMID 12240302 DOI: 10.1039/B106090M |
0.506 |
|
| 2002 |
Bruckbauer A, Ying L, Rothery AM, Zhou D, Shevchuk AI, Abell C, Korchev YE, Klenerman D. Writing with DNA and protein using a nanopipet for controlled delivery. Journal of the American Chemical Society. 124: 8810-1. PMID 12137530 DOI: 10.1021/Ja026816C |
0.552 |
|
| 2002 |
Blundell TL, Jhoti H, Abell C. High-throughput crystallography for lead discovery in drug design. Nature Reviews. Drug Discovery. 1: 45-54. PMID 12119609 DOI: 10.1038/Nrd706 |
0.488 |
|
| 2002 |
Roszak AW, Robinson DA, Krell T, Hunter IS, Fredrickson M, Abell C, Coggins JR, Lapthorn AJ. The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. Structure (London, England : 1993). 10: 493-503. PMID 11937054 DOI: 10.1016/S0969-2126(02)00747-5 |
0.358 |
|
| 2002 |
Matak-Vinković D, Vinković M, Saldanha SA, Ashurst JL, von Delft F, Inoue T, Miguel RN, Smith AG, Blundell TL, Abell C. Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism. Biochemistry. 40: 14493-500. PMID 11724562 DOI: 10.1021/Bi011020W |
0.512 |
|
| 2002 |
Frederickson M, Coggins JR, Abell C. Vinyl fluoride as an isoelectronic replacement for an enolate anion: Inhibition of type II dehydroquinases Chemical Communications. 8: 1886-1887. DOI: 10.1039/B205105M |
0.33 |
|
| 2001 |
Parker EJ, Bulloch EM, Jameson GB, Abell C. Substrate deactivation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase by erythrose 4-phosphate. Biochemistry. 40: 14821-8. PMID 11732901 DOI: 10.1021/Bi010928J |
0.605 |
|
| 2001 |
von Delft F, Lewendon A, Dhanaraj V, Blundell TL, Abell C, Smith AG. The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily. Structure (London, England : 1993). 9: 439-50. PMID 11377204 DOI: 10.1016/S0969-2126(01)00604-9 |
0.488 |
|
| 2001 |
Todd MH, Abell C. Novel chemical tagging method for combinatorial synthesis utilizing suzuki chemistry and fourier transform ion cyclotron resonance mass spectrometry. Journal of Combinatorial Chemistry. 3: 319-27. PMID 11350256 DOI: 10.1021/Cc000112M |
0.557 |
|
| 2001 |
Fiorini M, McKendry R, Cooper MA, Rayment T, Abell C. Chemical Force Microscopy with Active Enzymes Biophysical Journal. 80: 2471-2476. PMID 11325745 DOI: 10.1016/S0006-3495(01)76215-7 |
0.329 |
|
| 2000 |
Osborne A, Thorneley RN, Abell C, Bornemann S. Studies with substrate and cofactor analogues provide evidence for a radical mechanism in the chorismate synthase reaction. The Journal of Biological Chemistry. 275: 35825-30. PMID 10956653 DOI: 10.1074/Jbc.M005796200 |
0.349 |
|
| 2000 |
Parker EJ, González Bello C, Coggins JR, Hawkins AR, Abell C. Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids. Bioorganic & Medicinal Chemistry Letters. 10: 231-4. PMID 10698442 DOI: 10.1016/S0960-894X(99)00660-5 |
0.551 |
|
| 2000 |
Todd MH, Abell C. The attachment and cleavage of phenols from solid supports and their single bead mass spectral analysis Tetrahedron Letters. 41: 8183-8187. DOI: 10.1016/S0040-4039(00)01431-3 |
0.544 |
|
| 1999 |
Frederickson M, Parker EJ, Hawkins AR, Coggins JR, Abell C. Selective Inhibition of Type II Dehydroquinases. The Journal of Organic Chemistry. 64: 2612-2613. PMID 11674325 DOI: 10.1021/Jo990004Q |
0.509 |
|
| 1999 |
GENSCHEL U, POWELL CA, ABELL C, SMITH AG. The final step of pantothenate biosynthesis in higher plants: cloning and characterization of pantothenate synthetase from Lotus japonicus and Oryza sativum (rice) Biochemical Journal. 341: 669-678. DOI: 10.1042/Bj3410669 |
0.304 |
|
| 1999 |
Todd MH, Oliver SF, Abell C. A novel safety-catch linker for the solid-phase synthesis of amides and esters Organic Letters. 1: 1149-1151. DOI: 10.1021/Ol990785H |
0.545 |
|
| 1998 |
Abell C. Enzymes that exploit imines--one way or the other. Biochemical Society Transactions. 26: 310-5. PMID 9765870 DOI: 10.1042/Bst0260310 |
0.309 |
|
| 1998 |
Albert A, Dhanaraj V, Genschel U, Khan G, Ramjee MK, Pulido R, Sibanda BL, von Delft F, Witty M, Blundell TL, Smith AG, Abell C. Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing. Nature Structural Biology. 5: 289-93. PMID 9546220 DOI: 10.1038/Nsb0498-289 |
0.311 |
|
| 1997 |
Parker EJ, Coggins JR, Abell C. Derailing Dehydroquinate Synthase by Introducing a Stabilizing Stereoelectronic Effect in a Reaction Intermediate. The Journal of Organic Chemistry. 62: 8582-8585. PMID 11672011 DOI: 10.1021/Jo9713060 |
0.521 |
|
| 1997 |
Ramjee MK, Genschel U, Abell C, Smith AG. Escherichia coli L-aspartate-alpha-decarboxylase: preprotein processing and observation of reaction intermediates by electrospray mass spectrometry. The Biochemical Journal. 661-9. PMID 9169598 DOI: 10.1042/Bj3230661 |
0.305 |
|
| 1997 |
Cheung YW, Abell C, Balasubramanian S. A Combinatorial Approach to Identifying Protein Tyrosine Phosphatase Substrates from a Phosphotyrosine Peptide Library Journal of the American Chemical Society. 119: 9568-9569. DOI: 10.1021/Ja971825K |
0.667 |
|
| 1997 |
Todd MH, Balasubramanian S, Abell C. Studies on the synthesis, characterisation and reactivity of aromatic diboronic acids Tetrahedron Letters. 38: 6781-6784. DOI: 10.1016/S0040-4039(97)01552-9 |
0.615 |
|
| 1997 |
Arumugam V, Routledge A, Abell C, Balasubramanian S. Synthesis of 2-oxindole derivatives via the intramolecular Heck reaction on solid support Tetrahedron Letters. 38: 6473-6476. DOI: 10.1016/S0040-4039(97)01481-0 |
0.763 |
|
| 1997 |
Routledge A, Abell C, Balasubramanian S. The use of a dithiane protected benzoin photolabile safety catch linker for solid-phase synthesis Tetrahedron Letters. 38: 1227-1230. DOI: 10.1016/S0040-4039(96)02478-1 |
0.678 |
|
| 1995 |
Bornemann S, Balasubramanian S, Coggins JR, Abell C, Lowe DJ, Thorneley RN. Escherichia coli chorismate synthase: a deuterium kinetic-isotope effect under single-turnover and steady-state conditions shows that a flavin intermediate forms before the C-(6proR)-H bond is cleaved. The Biochemical Journal. 305: 707-10. PMID 7848266 DOI: 10.1042/Bj3050707 |
0.47 |
|
| 1995 |
Borthwick EB, Connell SJ, Tudor DW, Robins DJ, Shneier A, Abell C, Coggins JR. Escherichia coli dihydrodipicolinate synthase: characterization of the imine intermediate and the product of bromopyruvate treatment by electrospray mass spectrometry. The Biochemical Journal. 305: 521-4. PMID 7832769 DOI: 10.1042/Bj3050521 |
0.34 |
|
| 1995 |
Balasubramanian S, Coggins JR, Abell C. Observation of a secondary tritium isotope effect in the chorismate synthase reaction. Biochemistry. 34: 341-8. PMID 7819217 DOI: 10.1021/Bi00001A042 |
0.466 |
|
| 1995 |
Bornemann S, Ramjee MK, Balasubramanian S, Abell C, Coggins JR, Lowe DJ, Thorneley RN. Escherichia coli chorismate synthase catalyzes the conversion of (6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate to 6-fluorochorismate. Implications for the enzyme mechanism and the antimicrobial action of (6S)-6-fluoroshikimate. The Journal of Biological Chemistry. 270: 22811-5. PMID 7559411 DOI: 10.1074/Jbc.270.39.22811 |
0.511 |
|
| 1995 |
Duggan PJ, Parker E, Coggins J, Abell C. Enzymatic synthesis of (6R)- and (6S)-fluoroshikimic acids Bioorganic and Medicinal Chemistry Letters. 5: 2347-2352. DOI: 10.1016/0960-894X(95)00405-I |
0.526 |
|
| 1994 |
Wallis R, Reilly A, Barnes K, Abell C, Campbell DG, Moore GR, James R, Kleanthous C. Tandem overproduction and characterisation of the nuclease domain of colicin E9 and its cognate inhibitor protein Im9. European Journal of Biochemistry / Febs. 220: 447-54. PMID 8125102 DOI: 10.1111/J.1432-1033.1994.Tb18642.X |
0.325 |
|
| 1993 |
Hädener A, Matzinger PK, Malashkevich VN, Louie GV, Wood SP, Oliver P, Alefounder PR, Pitt AR, Abell C, Battersby AR. Purification, characterization, crystallisation and X-ray analysis of selenomethionine-labelled hydroxymethylbilane synthase from Escherichia coli. European Journal of Biochemistry / Febs. 211: 615-24. PMID 8436121 DOI: 10.1111/J.1432-1033.1993.Tb17589.X |
0.334 |
|
| 1992 |
Thorneley RN, Abell C, Ashby GA, Drummond MH, Eady RR, Huff S, Macdonald CJ, Shneier A. Posttranslational modification of Klebsiella pneumoniae flavodoxin by covalent attachment of coenzyme A, shown by 31P NMR and electrospray mass spectrometry, prevents electron transfer from the nifJ protein to nitrogenase. A possible new regulatory mechanism for biological nitrogen fixation. Biochemistry. 31: 1216-24. PMID 1734967 DOI: 10.1021/Bi00119A035 |
0.302 |
|
| 1992 |
Ramjee MN, Balasubramanian S, Abell C, Coggins JR, Davies GM, Hawkes TR, Lowe DJ, Thorneley RNF. Reaction of (6R)-6-fluoroEPSP with recombinant Escherichia coli chorismate synthase generates a stable flavin mononucleotide semiquinone radical Journal of the American Chemical Society. 114: 3151-3153. DOI: 10.1021/Ja00034A079 |
0.448 |
|
| 1991 |
Lander M, Pitt AR, Alefounder PR, Bardy D, Abell C, Battersby AR. Studies on the mechanism of hydroxymethylbilane synthase concerning the role of arginine residues in substrate binding. The Biochemical Journal. 275: 447-52. PMID 2025226 DOI: 10.1042/Bj2750447 |
0.357 |
|
| 1991 |
Cane DE, Abell C, Harrison PH, Hubbard BR, Kane CT, Lattman R, Oliver JS, Weiner SW. Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 332: 123-9. PMID 1678531 DOI: 10.1098/Rstb.1991.0040 |
0.619 |
|
| 1991 |
Balasubramanian S, Davies GM, Coggins JR, Abell C. Inhibition of chorismate synthase by (6R)- and (6S)-6-fluoro-5-enolpyruvylshikimate 3-phosphate Journal of the American Chemical Society. 113: 8945-8946. DOI: 10.1021/Ja00023A051 |
0.439 |
|
| 1991 |
Balasubramanian S, Abell C. The synthesis of (6R)-[6-2H]- and (6S)-[6-2H]5-enolpyruvylshikimate-3-phosphate Tetrahedron Letters. 32: 963-966. DOI: 10.1016/S0040-4039(00)92131-2 |
0.456 |
|
| 1991 |
Crockett N, Alefounder PR, Battersby AR, Abell C. Uroporphyrinogen III synthase: Studies on its mechanism of action, molecular biology and biochemistry Tetrahedron. 47: 6003-6014. DOI: 10.1016/S0040-4020(01)86492-9 |
0.309 |
|
| 1990 |
Hädener A, Alefounder PR, Hart GJ, Abell C, Battersby AR. Investigation of putative active-site lysine residues in hydroxymethylbilane synthase. Preparation and characterization of mutants in which (a) Lys-55, (b) Lys-59 and (c) both Lys-55 and Lys-59 have been replaced by glutamine. The Biochemical Journal. 271: 487-91. PMID 2122889 DOI: 10.1042/Bj2710487 |
0.34 |
|
| 1990 |
Balasubramanian S, Abell C, Coggins JR. Observation of an isotope effect in the chorismate synthase reaction Journal of the American Chemical Society. 112: 8581-8583. DOI: 10.1021/Ja00179A052 |
0.442 |
|
| 1990 |
Cane DE, Oliver JS, Harrison PHM, Abell C, Hubbard BR, Kane CT, Lattman R. Biosynthesis of pentalenene and pentalenolactone Journal of the American Chemical Society. 112: 4513-4524. DOI: 10.1021/Ja00167A059 |
0.618 |
|
| 1989 |
Miller AD, Packman LC, Hart GJ, Alefounder PR, Abell C, Battersby AR. Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase). The Biochemical Journal. 262: 119-24. PMID 2510713 DOI: 10.1042/Bj2620119 |
0.32 |
|
| 1989 |
Sharif AL, Smith AG, Abell C. Isolation and characterisation of a cDNA clone for a chlorophyll synthesis enzyme from Euglena gracilis. The chloroplast enzyme hydroxymethylbilane synthase (porphobilinogen deaminase) is synthesised with a very long transit peptide in Euglena. European Journal of Biochemistry. 184: 353-9. PMID 2477247 DOI: 10.1111/J.1432-1033.1989.Tb15026.X |
0.313 |
|
| 1989 |
Alefounder PR, Hart GJ, Miller AD, Beifuss U, Abell C, Leeper FJ, Battersby AR. Biosynthesis of the pigments of life: Structure and mode of action of a novel enzymatic cofactor Bioorganic Chemistry. 17: 121-129. DOI: 10.1016/0045-2068(89)90013-8 |
0.335 |
|
| 1988 |
Cane DE, Abell C, Lattman R, Kane CT, Hubbard BR, Harrison PHM. Pentalenene biosynthesis and the enzymatic cyclization of farnesyl pyrophosphate. Anti stereochemistry in a biological SE' reaction Journal of the American Chemical Society. 110: 4081-4082. DOI: 10.1021/Ja00220A081 |
0.604 |
|
| 1987 |
Abell C, Sutkowski AC, Staunton J. Studies on the biosynthesis of hydroxymellein using 17O n.m.r. and 2H n.m.r. spectroscopy to determine the origin of the C-4 hydroxy group Journal of the Chemical Society, Chemical Communications. 586-587. DOI: 10.1039/C39870000586 |
0.462 |
|
| 1986 |
Abell C, Bush BD, Staunton J. Biomimetic syntheses of the polyketide fungal metabolites alternariol and rubrofusarin: models for cyclisation reactions catalysed by polyketide synthase enzymes Journal of the Chemical Society, Chemical Communications. 15-17. DOI: 10.1039/C39860000015 |
0.547 |
|
| 1984 |
Abell C, Staunton J. Biosynthesis of 6-methylsalicylic acid; the combined use of mono- and tri-duteriated acetate precursors to investigate the degree of stereocontrol in the aromatisation sequence Journal of the Chemical Society, Chemical Communications. 1005-1007. DOI: 10.1039/C39840001005 |
0.508 |
|
| 1984 |
Cane DE, Abell C, Tillman AM. Pentalenene biosynthesis and the enzymatic cyclization of farnesyl pyrophosphate: Proof that the cyclization is catalyzed by a single enzyme Bioorganic Chemistry. 12: 312-328. DOI: 10.1016/0045-2068(84)90013-0 |
0.637 |
|
| 1983 |
Abell C, Doddrell DM, Garson MJ, Laue ED, Staunton J. Biosynthesis of the polyketide mellein from CD3CO2H and 13CD3CO2H in Aspergillus melleus: detection of deuterium by 2H n.m.r. and edited 13C n.m.r. spectra Journal of the Chemical Society, Chemical Communications. 694-696. DOI: 10.1039/C39830000694 |
0.466 |
|
| 1982 |
Abell C, Garson MJ, Leeper FJ, Staunton J. Biosynthesis of the fungal metabolites alternariol, mellein, rubrofusarin, and 6-methylsalicylic acid from CD3CO2H Journal of the Chemical Society, Chemical Communications. 1011-1013. DOI: 10.1039/C39820001011 |
0.475 |
|
| 1981 |
Abell C, Staunton J. The use of 2H n.m.r. spectroscopy and β-isotopic shifts in the 13C n.m.r. spectrum to measure deuterium retention in the biosynthesis of the polyketide 6-methylsalicylic acid Journal of the Chemical Society, Chemical Communications. 856-858. DOI: 10.1039/C39810000856 |
0.469 |
|
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