| Year |
Citation |
Score |
| 2024 |
Bruggeman E, Zhang O, Needham LM, Körbel M, Daly S, Cheetham M, Peters R, Wu T, Klymchenko AS, Davis SJ, Paluch EK, Klenerman D, Lew MD, O'Holleran K, Lee SF. POLCAM: instant molecular orientation microscopy for the life sciences. Nature Methods. PMID 39375574 DOI: 10.1038/s41592-024-02382-8 |
0.796 |
|
| 2024 |
Furlepa M, Zhang YP, Lobanova E, Kahanawita L, Vivacqua G, Williams-Gray CH, Klenerman D. Single-molecule characterization of salivary protein aggregates from Parkinson's disease patients: a pilot study. Brain Communications. 6: fcae178. PMID 38863577 DOI: 10.1093/braincomms/fcae178 |
0.327 |
|
| 2024 |
Xia Z, Prescott EE, Urbanek A, Wareing HE, King MC, Olerinyova A, Dakin H, Leah T, Barnes KA, Matuszyk MM, Dimou E, Hidari E, Zhang YP, Lam JYL, Danial JSH, ... ... Klenerman D, et al. Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease. Nature Communications. 15: 4695. PMID 38824138 DOI: 10.1038/s41467-024-49028-z |
0.695 |
|
| 2024 |
Böken D, Cox D, Burke M, Lam JYL, Katsinelos T, Danial JSH, Fertan E, McEwan WA, Rowe JB, Klenerman D. Single-Molecule Characterization and Super-Resolution Imaging of Alzheimer's Disease-Relevant Tau Aggregates in Human Samples. Angewandte Chemie (International Ed. in English). e202317756. PMID 38523073 DOI: 10.1002/anie.202317756 |
0.308 |
|
| 2024 |
Daly S, Ferreira Fernandes J, Bruggeman E, Handa A, Peters R, Benaissa S, Zhang B, Beckwith JS, Sanders EW, Sims RR, Klenerman D, Davis SJ, O'Holleran K, Lee SF. High-density volumetric super-resolution microscopy. Nature Communications. 15: 1940. PMID 38431671 DOI: 10.1038/s41467-024-45828-5 |
0.629 |
|
| 2024 |
Lippert AH, Paluch C, Gaglioni M, Vuong MT, McColl J, Jenkins E, Fellermeyer M, Clarke J, Sharma S, Moreira da Silva S, Akkaya B, Anzilotti C, Morgan SH, Jessup CF, Körbel M, ... ... Klenerman D, et al. Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases. Immunity. 57: 256-270.e10. PMID 38354703 DOI: 10.1016/j.immuni.2024.01.007 |
0.562 |
|
| 2023 |
Fertan E, Böken D, Murray A, Danial JSH, Lam JYL, Wu Y, Goh PA, Alić I, Cheetham MR, Lobanova E, Zhang YP, Nižetić D, Klenerman D. Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy. Molecular Psychiatry. PMID 38102482 DOI: 10.1038/s41380-023-02333-3 |
0.322 |
|
| 2023 |
Xia Z, Wu Y, Lam JYL, Zhang Z, Burke M, Fertan E, Ranasinghe RT, Hidari E, Danial JSH, Klenerman D. A computational suite for the structural and functional characterization of amyloid aggregates. Cell Reports Methods. 3: 100499. PMID 37426747 DOI: 10.1016/j.crmeth.2023.100499 |
0.3 |
|
| 2023 |
Jenkins E, Körbel M, O'Brien-Ball C, McColl J, Chen KY, Kotowski M, Humphrey J, Lippert AH, Brouwer H, Santos AM, Lee SF, Davis SJ, Klenerman D. Antigen discrimination by T cells relies on size-constrained microvillar contact. Nature Communications. 14: 1611. PMID 36959206 DOI: 10.1038/s41467-023-36855-9 |
0.607 |
|
| 2022 |
Sanders EW, Carr AR, Bruggeman E, Körbel M, Benaissa SI, Donat RF, Santos AM, McColl J, O'Holleran K, Klenerman D, Davis SJ, Lee SF, Ponjavic A. resPAINT: Accelerating Volumetric Super-Resolution Localisation Microscopy by Active Control of Probe Emission. Angewandte Chemie (Weinheim An Der Bergstrasse, Germany). 134: e202206919. PMID 38505515 DOI: 10.1002/ange.202206919 |
0.794 |
|
| 2022 |
Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, Fedotova EI, Berezhnov AV, De S, Peddie CJ, Athauda D, Virdi GS, Zhang W, Evans JR, Wernick AI, Zanjani ZS, ... ... Klenerman D, et al. Author Correction: Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity. Nature Neuroscience. PMID 36261654 DOI: 10.1038/s41593-022-01206-2 |
0.78 |
|
| 2022 |
Emin D, Zhang YP, Lobanova E, Miller A, Li X, Xia Z, Dakin H, Sideris DI, Lam JYL, Ranasinghe RT, Kouli A, Zhao Y, De S, Knowles TPJ, Vendruscolo M, ... ... Klenerman D, et al. Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease. Nature Communications. 13: 5512. PMID 36127374 DOI: 10.1038/s41467-022-33252-6 |
0.714 |
|
| 2022 |
Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, Fedotova EI, Berezhnov AV, De S, Peddie CJ, Athauda D, Virdi GS, Zhang W, Evans JR, Wernick AI, Zanjani ZS, ... ... Klenerman D, et al. Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity. Nature Neuroscience. PMID 36042314 DOI: 10.1038/s41593-022-01140-3 |
0.803 |
|
| 2022 |
Sanders EW, Carr AR, Bruggeman E, Körbel M, Benaissa SI, Donat RF, Santos AM, McColl J, O'Holleran K, Klenerman D, Davis SJ, Lee SF, Ponjavic A. resPAINT: Accelerating volumetric super-resolution localisation microscopy by active control of probe emission. Angewandte Chemie (International Ed. in English). PMID 35876263 DOI: 10.1002/anie.202206919 |
0.794 |
|
| 2022 |
Meng JX, Zhang Y, Saman D, Haider AM, De S, Sang JC, Brown K, Jiang K, Humphrey J, Julian L, Hidari E, Lee SF, Balmus G, Floto RA, Bryant CE, ... ... Klenerman D, et al. Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses. Nature Communications. 13: 2692. PMID 35577786 DOI: 10.1038/s41467-022-30461-x |
0.787 |
|
| 2021 |
Chen KY, Jenkins E, Körbel M, Ponjavic A, Lippert AH, Santos AM, Ashman N, O'Brien-Ball C, McBride J, Klenerman D, Davis SJ. Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34526387 DOI: 10.1073/pnas.2024250118 |
0.682 |
|
| 2021 |
Lobanova E, Whiten D, Ruggeri FS, Taylor C, Kouli A, Xia Z, Emin D, Zhang YP, Lam JYL, Williams-Gray CH, Klenerman D. Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson's disease. Brain : a Journal of Neurology. PMID 34410317 DOI: 10.1093/brain/awab306 |
0.306 |
|
| 2021 |
Sideris DI, Danial JSH, Emin D, Ruggeri FS, Xia Z, Zhang YP, Lobanova E, Dakin H, De S, Miller A, Sang JC, Knowles TPJ, Vendruscolo M, Fraser G, Crowther D, ... Klenerman D, et al. Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer's disease. Brain Communications. 3: fcab147. PMID 34396107 DOI: 10.1093/braincomms/fcab147 |
0.683 |
|
| 2021 |
Klenerman D, Sanchez SE, Whiten DR, Meisl G, Ruggeri FS, Hidari E. Alpha synuclein only forms fibrils in vitro when larger than its critical size of 70 monomers. Chembiochem : a European Journal of Chemical Biology. PMID 34383993 DOI: 10.1002/cbic.202100285 |
0.785 |
|
| 2021 |
Sanna E, Rodrigues M, Fagan SG, Chisholm TS, Kulenkampff K, Klenerman D, Spillantini MG, Aigbirhio FI, Hunter CA. Mapping the binding site topology of amyloid protein aggregates using multivalent ligands. Chemical Science. 12: 8892-8899. PMID 34257890 DOI: 10.1039/d1sc01263k |
0.301 |
|
| 2021 |
Sang JC, Hidari E, Meisl G, Ranasinghe RT, Spillantini MG, Klenerman D. Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells. Communications Biology. 4: 613. PMID 34021258 DOI: 10.1038/s42003-021-02126-w |
0.307 |
|
| 2021 |
Vilalta A, Zhou Y, Sevalle J, Griffin JK, Satoh K, Allendorf DH, De S, Puigdellívol M, Bruzas A, Burguillos MA, Dodd RB, Chen F, Zhang Y, Flagmeier P, Needham LM, ... ... Klenerman D, et al. Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation. The Journal of Biological Chemistry. 100631. PMID 33823153 DOI: 10.1016/j.jbc.2021.100631 |
0.8 |
|
| 2021 |
Danial JSH, Klenerman D. Single molecule imaging of protein aggregation in Dementia: Methods, insights and prospects. Neurobiology of Disease. 153: 105327. PMID 33705938 DOI: 10.1016/j.nbd.2021.105327 |
0.333 |
|
| 2021 |
Li B, Ponjavic A, Chen WH, Hopkins L, Hughes C, Ye Y, Bryant C, Klenerman D. Single-Molecule Light-Sheet Microscopy with Local Nanopipette Delivery. Analytical Chemistry. PMID 33595281 DOI: 10.1021/acs.analchem.0c05296 |
0.749 |
|
| 2020 |
Zhao Y, Tietz O, Kuan WL, Haji-Dheere AK, Thompson S, Vallin B, Ronchi E, Tóth G, Klenerman D, Aigbirhio FI. A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein. Chemical Science. 11: 4773-4778. PMID 34122933 DOI: 10.1039/c9sc05620c |
0.335 |
|
| 2020 |
Needham LM, Weber J, Varela JA, Fyfe JWB, Do DT, Xu CK, Tutton L, Cliffe R, Keenlyside B, Klenerman D, Dobson CM, Hunter CA, Müller KH, O'Holleran K, Bohndiek SE, et al. ThX - a next-generation probe for the early detection of amyloid aggregates. Chemical Science. 11: 4578-4583. PMID 34122915 DOI: 10.1039/c9sc04730a |
0.832 |
|
| 2020 |
Whiten DR, Brownjohn PW, Moore S, De S, Strano A, Zuo Y, Haneklaus M, Klenerman D, Livesey FJ. Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer's disease neurons. Brain Communications. 2: fcaa146. PMID 33543132 DOI: 10.1093/braincomms/fcaa146 |
0.711 |
|
| 2020 |
Angelova PR, Choi ML, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D, Dolt KS, Kunath T, Devine MJ, Gissen P, Shchepinov MS, Sylantyev S, ... ... Klenerman D, et al. Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. Cell Death and Differentiation. PMID 33041329 DOI: 10.1038/s41418-020-00634-6 |
0.777 |
|
| 2020 |
Flagmeier P, De S, Michaels TCT, Yang X, Dear AJ, Emanuelsson C, Vendruscolo M, Linse S, Klenerman D, Knowles TPJ, Dobson CM. Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation. Nature Structural & Molecular Biology. PMID 32778821 DOI: 10.1038/S41594-020-0471-Z |
0.737 |
|
| 2020 |
Di Antonio M, Ponjavic A, Radzevičius A, Ranasinghe RT, Catalano M, Zhang X, Shen J, Needham LM, Lee SF, Klenerman D, Balasubramanian S. Single-molecule visualization of DNA G-quadruplex formation in live cells. Nature Chemistry. PMID 32690897 DOI: 10.1038/S41557-020-0506-4 |
0.78 |
|
| 2020 |
Dear AJ, Michaels TCT, Meisl G, Klenerman D, Wu S, Perrett S, Linse S, Dobson CM, Knowles TPJ. Kinetic diversity of amyloid oligomers. Proceedings of the National Academy of Sciences of the United States of America. PMID 32414930 DOI: 10.1073/Pnas.1922267117 |
0.409 |
|
| 2020 |
Angelova PR, Choi ML, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D, Dolt KS, Kunath T, Devine MJ, Gissen P, Shchepinov MS, Sylantyev S, ... ... Klenerman D, et al. Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. Cell Death and Differentiation. PMID 32409771 DOI: 10.1038/S41418-020-0552-X |
0.777 |
|
| 2020 |
Angelova PR, Choi ML, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D, Dolt KS, Kunath T, Devine MJ, Gissen P, Shchepinov MS, Sylantyev S, ... ... Klenerman D, et al. Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. Cell Death and Differentiation. PMID 32341450 DOI: 10.1038/S41418-020-0542-Z |
0.803 |
|
| 2020 |
Esteras N, Kundel F, Amodeo GF, Pavlov EV, Klenerman D, Abramov AY. Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage-gated calcium channels and NADPH oxidase. The Febs Journal. PMID 32338825 DOI: 10.1111/Febs.15340 |
0.38 |
|
| 2020 |
Sanderson JB, De S, Jiang H, Rovere M, Jin M, Zaccagnini L, Hays Watson A, De Boni L, Lagomarsino VN, Young-Pearse TL, Liu X, Pochapsky TC, Hyman BT, Dickson DW, Klenerman D, et al. Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies. Brain Communications. 2: fcaa010. PMID 32280944 DOI: 10.1093/braincomms/fcaa010 |
0.682 |
|
| 2020 |
Meisl G, Knowles TP, Klenerman D. The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation. Current Opinion in Neurobiology. 61: 58-64. PMID 32092527 DOI: 10.1016/J.Conb.2020.01.010 |
0.413 |
|
| 2020 |
Kulenkampff K, Lippert AH, McColl J, Santos AM, Ponjavic A, Jenkins E, Humphrey J, Winkel A, Franze K, Lee SF, Davis SJ, Klenerman D. The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale. Biophysical Journal. PMID 32075748 DOI: 10.1016/J.Bpj.2020.01.019 |
0.789 |
|
| 2020 |
Zhao Y, Tietz O, Kuan W, Haji-Dheere AK, Thompson S, Vallin B, Ronchi E, Tóth G, Klenerman D, Aigbirhio FI. A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein Chemical Science. 11: 4773-4778. DOI: 10.1039/C9Sc05620C |
0.446 |
|
| 2020 |
Needham L, Weber J, Varela JA, Fyfe JWB, Do DT, Xu CK, Tutton L, Cliffe R, Keenlyside B, Klenerman D, Dobson CM, Hunter CA, Müller KH, O'Holleran K, Bohndiek SE, et al. ThX – a next-generation probe for the early detection of amyloid aggregates Chemical Science. 11: 4578-4583. DOI: 10.1039/C9Sc04730A |
0.807 |
|
| 2020 |
Emin D, Rodrigues M, Xia Z, Kouli A, Henson H, Williams-Gray C, Klenerman D. Size-Dependent Characterization of Alpha-Synuclein Aggregates Unveils their Toxicity Biophysical Journal. 118: 492a. DOI: 10.1016/J.Bpj.2019.11.2724 |
0.332 |
|
| 2020 |
Choi ML, Horrocks MH, Rodrigues M, De S, Tosatto L, Zhang W, Virdi G, Klenerman D, Abramov AY, Gandhi S. Tracking Oligomerization of Alpha-Synuclein Demonstrates Pivotal Role of Mitochondria in Seeding Biophysical Journal. 118: 217a. DOI: 10.1016/J.Bpj.2019.11.1289 |
0.763 |
|
| 2019 |
Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, ... ... Klenerman D, et al. α-Synuclein strains target distinct brain regions and cell types. Nature Neuroscience. PMID 31792467 DOI: 10.1038/S41593-019-0541-X |
0.326 |
|
| 2019 |
Ye Y, Klenerman D, Finley D. N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of their Oligomers by the Proteasome Holoenzyme. Journal of Molecular Biology. PMID 31518613 DOI: 10.1016/J.Jmb.2019.08.021 |
0.407 |
|
| 2019 |
De S, Whiten DR, Ruggeri FS, Hughes C, Rodrigues M, Sideris DI, Taylor CG, Aprile FA, Muyldermans S, Knowles TPJ, Vendruscolo M, Bryant C, Blennow K, Skoog I, Kern S, ... ... Klenerman D, et al. Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression. Acta Neuropathologica Communications. 7: 120. PMID 31349874 DOI: 10.1186/S40478-019-0777-4 |
0.727 |
|
| 2019 |
Fernandes RA, Ganzinger KA, Tzou JC, Jönsson P, Lee SF, Palayret M, Santos AM, Carr AR, Ponjavic A, Chang VT, Macleod C, Lagerholm BC, Lindsay AE, Dushek O, Tilevik A, ... ... Klenerman D, et al. A cell topography-based mechanism for ligand discrimination by the T cell receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31221762 DOI: 10.1073/Pnas.1817255116 |
0.78 |
|
| 2019 |
Sang JC, Lee JE, Dear AJ, De S, Meisl G, Thackray AM, Bujdoso R, Knowles TPJ, Klenerman D. Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species. Chemical Science. 10: 4588-4597. PMID 31123569 DOI: 10.1039/C8Sc05627G |
0.762 |
|
| 2019 |
Scheidt T, Łapińska U, Kumita JR, Whiten DR, Klenerman D, Wilson MR, Cohen SIA, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ, Arosio P. Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates. Science Advances. 5: eaau3112. PMID 31001578 DOI: 10.1126/Sciadv.Aau3112 |
0.419 |
|
| 2019 |
De S, Wirthensohn DC, Flagmeier P, Hughes C, Aprile FA, Ruggeri FS, Whiten DR, Emin D, Xia Z, Varela JA, Sormanni P, Kundel F, Knowles TPJ, Dobson CM, Bryant C, ... ... Klenerman D, et al. Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms. Nature Communications. 10: 1541. PMID 30948723 DOI: 10.1038/S41467-019-09477-3 |
0.732 |
|
| 2019 |
Stern HL, Wang R, Fan Y, Mizuta R, Stewart JC, Needham LM, Roberts TD, Wai R, Ginsberg NS, Klenerman D, Hofmann S, Lee SF. Spectrally-Resolved Photodynamics Of Individual Emitters In Large-Area Monolayers Of Hexagonal-Boron Nitride. Acs Nano. PMID 30865421 DOI: 10.1021/Acsnano.9B00274 |
0.773 |
|
| 2019 |
Weiffert T, Meisl G, Flagmeier P, De S, Dunning CJR, Frohm B, Zetterberg H, Blennow K, Portelius E, Klenerman D, Dobson CM, Knowles TPJ, Linse S. Increased secondary nucleation underlies accelerated aggregation of the four-residue N-terminally truncated Aβ42 species Aβ5-42. Acs Chemical Neuroscience. PMID 30793584 DOI: 10.1021/Acschemneuro.8B00676 |
0.706 |
|
| 2019 |
Cliffe R, Sang JC, Kundel F, Finley D, Klenerman D, Ye Y. Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme. Cell Reports. 26: 2140-2149.e3. PMID 30784595 DOI: 10.1016/J.Celrep.2019.01.096 |
0.429 |
|
| 2019 |
De S, Klenerman D. Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease. Biochimica Et Biophysica Acta. Proteins and Proteomics. PMID 30611780 DOI: 10.1016/J.Bbapap.2018.12.010 |
0.742 |
|
| 2019 |
De S, Whiten DR, Hughes C, Klenerman D. O3-01-03: MECHANISM OF TOXICITY INDUCED BY AMYLOID-BETA AGGREGATES CHANGES DURING THE PROGRESSION OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P875-P876. DOI: 10.1016/J.Jalz.2019.06.4626 |
0.691 |
|
| 2018 |
Ponjavic A, Ye Y, Laue E, Lee SF, Klenerman D. Sensitive light-sheet microscopy in multiwell plates using an AFM cantilever. Biomedical Optics Express. 9: 5863-5880. PMID 31065399 DOI: 10.1364/Boe.9.005863 |
0.79 |
|
| 2018 |
Lee JE, Sang JC, Rodrigues M, Carr AR, Horrocks MH, De S, Bongiovanni MN, Flagmeier P, Dobson CM, Wales DJ, Lee SF, Klenerman D. Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale. Nano Letters. PMID 30380895 DOI: 10.1021/Acs.Nanolett.8B02916 |
0.82 |
|
| 2018 |
Iljina M, Dear AJ, Garcia GA, De S, Tosatto L, Flagmeier P, Whiten DR, Michaels TCT, Frenkel D, Dobson CM, Knowles TPJ, Klenerman D. Quantifying Co-Oligomer Formation by α-Synuclein. Acs Nano. PMID 30371053 DOI: 10.1021/Acsnano.8B03575 |
0.733 |
|
| 2018 |
Sang JC, Meisl G, Thackray AM, Hong L, Ponjavic A, Knowles TPJ, Bujdoso R, Klenerman D. Direct observation of murine prion protein replication in vitro. Journal of the American Chemical Society. PMID 30351023 DOI: 10.1021/Jacs.8B08311 |
0.762 |
|
| 2018 |
Hughes CD, Choi ML, Ryten M, Hopkins L, Drews A, Botía JA, Iljina M, Rodrigues M, Gagliano SA, Gandhi S, Bryant C, Klenerman D. Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis. Acta Neuropathologica. PMID 30225556 DOI: 10.1007/S00401-018-1907-Y |
0.308 |
|
| 2018 |
Taylor CG, Meisl G, Horrocks MH, Zetterberg H, Knowles TPJ, Klenerman D. Extrinsic Amyloid-Binding Dyes for the Detection of Individual Protein Aggregates in Solution. Analytical Chemistry. PMID 30059210 DOI: 10.1021/Acs.Analchem.8B02226 |
0.813 |
|
| 2018 |
Horrocks M, Whiten DR, Zuo Y, Calo L, Choi ML, De S, Flagmeier P, Wirthensohn DC, Kundel F, Lee SF, Dobson C, Gandhi S, Spillantini M, Klenerman D, Ranasinghe RT, et al. Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells. Chembiochem : a European Journal of Chemical Biology. PMID 30051958 DOI: 10.1002/Cbic.201800209 |
0.818 |
|
| 2018 |
Kjaergaard M, Dear AJ, Kundel F, Qamar S, Meisl G, Knowles TPJ, Klenerman D. Oligomer diversity during the aggregation of the repeat-region of tau. Acs Chemical Neuroscience. PMID 29953200 DOI: 10.1021/Acschemneuro.8B00250 |
0.445 |
|
| 2018 |
Whiten DR, Cox D, Horrocks MH, Taylor CG, De S, Flagmeier P, Tosatto L, Kumita JR, Ecroyd H, Dobson CM, Klenerman D, Wilson MR. Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers. Cell Reports. 23: 3492-3500. PMID 29924993 DOI: 10.1016/J.Celrep.2018.05.074 |
0.805 |
|
| 2018 |
Ludtmann MHR, Angelova PR, Horrocks MH, Choi ML, Rodrigues M, Baev AY, Berezhnov AV, Yao Z, Little D, Banushi B, Al-Menhali AS, Ranasinghe RT, Whiten DR, Yapom R, Dolt KS, ... ... Klenerman D, et al. α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease. Nature Communications. 9: 2293. PMID 29895861 DOI: 10.1038/S41467-018-04422-2 |
0.784 |
|
| 2018 |
Ponjavic A, McColl J, Carr AR, Santos AM, Kulenkampff K, Lippert A, Davis SJ, Klenerman D, Lee SF. Single-Molecule Light-Sheet Imaging of Suspended T Cells. Biophysical Journal. 114: 2200-2211. PMID 29742413 DOI: 10.1016/J.Bpj.2018.02.044 |
0.802 |
|
| 2018 |
Lee SF, Klenerman D. Weighing one protein with light. Science (New York, N.Y.). 360: 378-379. PMID 29700252 DOI: 10.1126/Science.Aat5851 |
0.651 |
|
| 2018 |
Kundel F, Hong L, Falcon B, McEwan W, Michaels TCT, Meisl G, Esteras N, Abramov AY, Knowles TPJ, Goedert M, Klenerman D. Measurement of tau filament fragmentation provides insights into prion-like spreading. Acs Chemical Neuroscience. PMID 29590529 DOI: 10.1021/Acschemneuro.8B00094 |
0.4 |
|
| 2018 |
Santos AM, Ponjavic A, Fritzsche M, Fernandes RA, de la Serna JB, Wilcock MJ, Schneider F, Urbančič I, McColl J, Anzilotti C, Ganzinger KA, Aßmann M, Depoil D, Cornall RJ, Dustin ML, ... Klenerman D, et al. Capturing resting T cells: the perils of PLL. Nature Immunology. PMID 29476188 DOI: 10.1038/S41590-018-0048-8 |
0.758 |
|
| 2018 |
Kundel F, Tosatto L, Whiten DR, Wirthensohn DC, Horrocks MH, Klenerman D. Shedding light on aberrant interactions: A review of modern tools for studying protein aggregates. The Febs Journal. PMID 29453901 DOI: 10.1111/Febs.14409 |
0.802 |
|
| 2018 |
Ranasinghe RT, Challand MR, Ganzinger KA, Lewis BW, Softley C, Schmied WH, Horrocks MH, Shivji N, Chin JW, Spencer J, Klenerman D. Detecting RNA base methylations in single cells by in situ hybridization. Nature Communications. 9: 655. PMID 29440632 DOI: 10.1038/S41467-017-02714-7 |
0.753 |
|
| 2018 |
Cox D, Whiten DR, Brown J, Horrocks MH, San Gil R, Dobson CM, Klenerman D, van Oijen AM, Ecroyd H. The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity. The Journal of Biological Chemistry. PMID 29382725 DOI: 10.1074/Jbc.M117.813865 |
0.792 |
|
| 2018 |
Varela JA, Rodrigues M, De S, Flagmeier P, Gandhi S, Dobson CM, Klenerman D, Lee S. Optical structural analysis of individual α-synuclein oligomers. Angewandte Chemie (International Ed. in English). PMID 29342318 DOI: 10.1002/Anie.201710779 |
0.811 |
|
| 2018 |
Kundel F, De S, Flagmeier P, Horrocks MH, Kjaergaard M, Shammas SL, Jackson SE, Dobson CM, Klenerman D. Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity. Acs Chemical Biology. PMID 29300447 DOI: 10.1021/Acschembio.7B01039 |
0.809 |
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| 2018 |
Angelova PR, Choi M, Horrocks MH, Klenerman D, Gandhi S, Abramov AY. Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation Free Radical Biology and Medicine. 120: S40. DOI: 10.1016/J.Freeradbiomed.2018.04.137 |
0.77 |
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| 2018 |
Whiten DR, Zuo Y, Calo L, Choi M, De S, Flagmeier P, Wirthensohn DC, Kundel F, Ranasinghe RT, Sanchez SE, Athauda D, Lee SF, Dobson CM, Gandhi S, Spillantini M, ... Klenerman D, et al. Cover Feature: Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells (ChemBioChem 19/2018) Chembiochem. 19: 2001-2001. DOI: 10.1002/Cbic.201800547 |
0.791 |
|
| 2017 |
Drews A, De S, Flagmeier P, Wirthensohn DC, Chen WH, Whiten DR, Rodrigues M, Vincke C, Muyldermans S, Paterson RW, Slattery CF, Fox NC, Schott JM, Zetterberg H, Dobson CM, ... ... Klenerman D, et al. Inhibiting the Ca2+ Influx Induced by Human CSF. Cell Reports. 21: 3310-3316. PMID 29241555 DOI: 10.1016/J.Celrep.2017.11.057 |
0.699 |
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| 2017 |
Felce JH, Davis SJ, Klenerman D. Single-Molecule Analysis of G Protein-Coupled Receptor Stoichiometry: Approaches and Limitations. Trends in Pharmacological Sciences. PMID 29122289 DOI: 10.1016/J.Tips.2017.10.005 |
0.303 |
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| 2017 |
Pfammatter M, Andreasen M, Meisl G, Taylor CG, Adamcik J, Bolisetty S, Sanchez-Ferrer A, Klenerman D, Dobson CM, Mezzenga R, Knowles TPJ, Aguzzi AA, Hornemann S. Absolute Quantification of Amyloid Propagons by Digital Microfluidics. Analytical Chemistry. PMID 28972786 DOI: 10.1021/Acs.Analchem.7B03279 |
0.361 |
|
| 2017 |
Felce JH, Latty SL, Knox RG, Mattick SR, Lui Y, Lee SF, Klenerman D, Davis SJ. Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure. Cell Reports. 20: 2654-2665. PMID 28903045 DOI: 10.1016/J.Celrep.2017.08.072 |
0.619 |
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| 2017 |
Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, ... ... Klenerman D, et al. Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species. Bmc Biology. 15: 57. PMID 28673288 DOI: 10.1186/S12915-017-0390-6 |
0.806 |
|
| 2017 |
Flagmeier P, De S, Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, Knowles TPJ, Gandhi S, Dobson CM, Klenerman D. Ultrasensitive Measurement of Ca(2+) Influx into Lipid Vesicles Induced by Protein Aggregates. Angewandte Chemie (International Ed. in English). PMID 28474754 DOI: 10.1002/Anie.201700966 |
0.801 |
|
| 2017 |
Carr AR, Ponjavic A, Basu S, McColl J, Santos AM, Davis S, Laue ED, Klenerman D, Lee SF. Three-Dimensional Super-Resolution in Eukaryotic Cells Using the Double-Helix Point Spread Function. Biophysical Journal. 112: 1444-1454. PMID 28402886 DOI: 10.1016/J.Bpj.2017.02.023 |
0.8 |
|
| 2017 |
Ludtmann M, Angelova P, Choi M, Horrocks M, Baev A, Little D, Devine M, Gissen P, Pavlov E, Klenerman D, Abramov A, Gandhi S. Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD Biophysical Journal. 112: 440a. DOI: 10.1016/J.Bpj.2016.11.2351 |
0.782 |
|
| 2016 |
Tyurikova O, Zheng K, Rings A, Drews A, Klenerman D, Rusakov DA. Monitoring Ca(2+) elevations in individual astrocytes upon local release of amyloid beta in acute brain slices. Brain Research Bulletin. PMID 28011193 DOI: 10.1016/J.Brainresbull.2016.12.007 |
0.303 |
|
| 2016 |
Bongiovanni MN, Godet J, Horrocks MH, Tosatto L, Carr AR, Wirthensohn DC, Ranasinghe RT, Lee JE, Ponjavic A, Fritz JV, Dobson CM, Klenerman D, Lee SF. Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping. Nature Communications. 7: 13544. PMID 27929085 DOI: 10.1038/Ncomms13544 |
0.797 |
|
| 2016 |
Iljina M, Tosatto L, Choi ML, Sang JC, Ye Y, Hughes CD, Bryant CE, Gandhi S, Klenerman D. Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein. Scientific Reports. 6: 33928. PMID 27671749 DOI: 10.1038/Srep33928 |
0.352 |
|
| 2016 |
Zhou Y, Basu S, Wohlfahrt KJ, Lee SF, Klenerman D, Laue ED, Seshia AA. A microfluidic platform for trapping, releasing and super-resolution imaging of single cells. Sensors and Actuators. B, Chemical. 232: 680-691. PMID 27594767 DOI: 10.1016/J.Snb.2016.03.131 |
0.633 |
|
| 2016 |
Drews A, Flint J, Shivji N, Jönsson P, Wirthensohn D, De Genst E, Vincke C, Muyldermans S, Dobson C, Klenerman D. Individual aggregates of amyloid beta induce temporary calcium influx through the cell membrane of neuronal cells. Scientific Reports. 6: 31910. PMID 27553885 DOI: 10.1038/Srep31910 |
0.354 |
|
| 2016 |
Iljina M, Garcia GA, Dear AJ, Flint J, Narayan P, Michaels TC, Dobson CM, Frenkel D, Knowles TP, Klenerman D. Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms. Scientific Reports. 6: 28658. PMID 27346247 DOI: 10.1038/Srep28658 |
0.423 |
|
| 2016 |
Shevchuk A, Tokar S, Gopal S, Sanchez-Alonso JL, Tarasov AI, Vélez-Ortega AC, Chiappini C, Rorsman P, Stevens MM, Gorelik J, Frolenkov GI, Klenerman D, Korchev YE. Angular Approach Scanning Ion Conductance Microscopy. Biophysical Journal. 110: 2252-2265. PMID 27224490 DOI: 10.1016/J.Bpj.2016.04.017 |
0.319 |
|
| 2016 |
Angelova PR, Ludtmann MH, Horrocks MH, Negoda A, Cremades N, Klenerman D, Dobson CM, Wood NW, Pavlov EV, Gandhi S, Abramov AY. Ca2+ is a key factor in α-synuclein-induced neurotoxicity. Development (Cambridge, England). 143: e1.1. PMID 27190039 DOI: 10.1242/dev.139345 |
0.731 |
|
| 2016 |
Zhang W, Aubert A, Gomez de Segura JM, Karuppasamy M, Basu S, Murthy A, Diamante A, Drury TA, Balmer J, Cramard J, Watson AA, Lando D, Lee SF, Palayret M, Kloet S, ... ... Klenerman D, et al. The Nucleosome Remodeling and Deacetylase Complex NuRD is built from preformed catalytically active sub-modules. Journal of Molecular Biology. PMID 27117189 DOI: 10.1016/J.Jmb.2016.04.025 |
0.625 |
|
| 2016 |
Jönsson P, Southcombe JH, Santos AM, Huo J, Fernandes RA, McColl J, Lever M, Evans EJ, Hudson A, Chang VT, Hanke T, Godkin A, Dunne PD, Horrocks MH, Palayret M, ... ... Klenerman D, et al. Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114505 DOI: 10.1073/Pnas.1513918113 |
0.747 |
|
| 2016 |
Broadhead MJ, Horrocks MH, Zhu F, Muresan L, Benavides-Piccione R, DeFelipe J, Fricker D, Kopanitsa MV, Duncan RR, Klenerman D, Komiyama NH, Lee SF, Grant SG. PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits. Scientific Reports. 6: 24626. PMID 27109929 DOI: 10.1038/Srep24626 |
0.768 |
|
| 2016 |
Chang VT, Fernandes RA, Ganzinger KA, Lee SF, Siebold C, McColl J, Jönsson P, Palayret M, Harlos K, Coles CH, Jones EY, Lui Y, Huang E, Gilbert RJ, Klenerman D, et al. Initiation of T cell signaling by CD45 segregation at 'close contacts'. Nature Immunology. PMID 26998761 DOI: 10.1038/Ni.3392 |
0.599 |
|
| 2016 |
Angelova PR, Ludtmann MH, Horrocks MH, Negoda A, Cremades N, Klenerman D, Dobson CM, Wood NW, Pavlov EV, Gandhi S, Abramov AY. Calcium is a key factor in α-synuclein induced neurotoxicity. Journal of Cell Science. PMID 26989132 DOI: 10.1242/Jcs.180737 |
0.775 |
|
| 2016 |
Iljina M, Garcia GA, Horrocks MH, Tosatto L, Choi ML, Ganzinger KA, Abramov AY, Gandhi S, Wood NW, Cremades N, Dobson CM, Knowles TP, Klenerman D. Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading. Proceedings of the National Academy of Sciences of the United States of America. PMID 26884195 DOI: 10.1073/Pnas.1524128113 |
0.806 |
|
| 2016 |
Horrocks MH, Lee SF, Gandhi S, Magdalinou NK, Chen SW, Devine MJ, Tosatto L, Kjaergaard M, Beckwith JS, Zetterberg H, Iljina M, Cremades N, Dobson CM, Wood NW, Klenerman D. Single-molecule imaging of individual amyloid protein aggregates in human biofluids. Acs Chemical Neuroscience. PMID 26800462 DOI: 10.1021/Acschemneuro.5B00324 |
0.827 |
|
| 2016 |
Zhou Y, Basu S, Wohlfahrt KJ, Lee SF, Klenerman D, Laue ED, Seshia AA. A microfluidic platform for trapping, releasing and super-resolution imaging of single cells Sensors and Actuators, B: Chemical. 232: 680-691. DOI: 10.1016/j.snb.2016.03.131 |
0.599 |
|
| 2016 |
Needham L, Basu S, Taylor E, Laue ED, Klenerman D, Lando D, Lee SF. Improved Photo Physical Properties of mEos3 for Single Molecule Tracking Biophysical Journal. 110: 485a-486a. DOI: 10.1016/J.Bpj.2015.11.2596 |
0.79 |
|
| 2016 |
Choi ML, Yao Z, Tosatto L, Klenerman D, Abramov AY, Gandhi S. Strain Dependent Effects of Alpha-Synuclein Mutations on Mitochondrial Dysfunction Biophysical Journal. 110: 471a. DOI: 10.1016/J.Bpj.2015.11.2522 |
0.368 |
|
| 2016 |
Taylor C, Knowles T, Klenerman D. Combining Single-Molecule Techniques with Microfluidics for Protein Analysis Biophysical Journal. 110: 195a. DOI: 10.1016/J.Bpj.2015.11.1086 |
0.431 |
|
| 2015 |
Tosatto L, Horrocks MH, Dear AJ, Knowles TP, Dalla Serra M, Cremades N, Dobson CM, Klenerman D. Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants. Scientific Reports. 5: 16696. PMID 26582456 DOI: 10.1038/Srep16696 |
0.786 |
|
| 2015 |
Deas E, Cremades N, Angelova PR, Ludtmann M, Yao Z, Chen S, Horrocks M, Banushi B, Little D, Devine M, Gissen P, Klenerman D, Dobson C, Wood N, Gandhi S, et al. Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson's disease. Antioxidants & Redox Signaling. PMID 26564470 DOI: 10.1089/Ars.2015.6343 |
0.776 |
|
| 2015 |
Latty SL, Felce JH, Weimann L, Lee SF, Davis SJ, Klenerman D. Referenced Single-Molecule Measurements Differentiate between GPCR Oligomerization States. Biophysical Journal. 109: 1798-806. PMID 26536257 DOI: 10.1016/J.Bpj.2015.09.004 |
0.655 |
|
| 2015 |
Horrocks MH, Tosatto L, Dear AJ, Garcia GA, Iljina M, Cremades N, Dalla Serra M, Knowles TP, Dobson CM, Klenerman D. Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α-Synuclein Oligomers. Analytical Chemistry. 87: 8818-26. PMID 26258431 DOI: 10.1021/Acs.Analchem.5B01811 |
0.802 |
|
| 2015 |
Reeve AK, Ludtmann MH, Angelova PR, Simcox EM, Horrocks MH, Klenerman D, Gandhi S, Turnbull DM, Abramov AY. Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons. Cell Death & Disease. 6: e1820. PMID 26181201 DOI: 10.1038/Cddis.2015.166 |
0.779 |
|
| 2015 |
Whitcomb DJ, Hogg EL, Regan P, Piers T, Narayan P, Whitehead G, Winters BL, Kim DH, Kim E, St George-Hyslop P, Klenerman D, Collingridge GL, Jo J, Cho K. Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus. Scientific Reports. 5: 10934. PMID 26055072 DOI: 10.1038/Srep10934 |
0.338 |
|
| 2015 |
Shammas SL, Garcia GA, Kumar S, Kjaergaard M, Horrocks MH, Shivji N, Mandelkow E, Knowles TP, Mandelkow E, Klenerman D. A mechanistic model of tau amyloid aggregation based on direct observation of oligomers. Nature Communications. 6: 7025. PMID 25926130 DOI: 10.1038/Ncomms8025 |
0.792 |
|
| 2015 |
Palayret M, Armes H, Basu S, Watson AT, Herbert A, Lando D, Etheridge TJ, Endesfelder U, Heilemann M, Laue E, Carr AM, Klenerman D, Lee SF. Virtual-'light-sheet' single-molecule localisation microscopy enables quantitative optical sectioning for super-resolution imaging. Plos One. 10: e0125438. PMID 25884495 DOI: 10.1371/Journal.Pone.0125438 |
0.656 |
|
| 2015 |
Chen SW, Drakulic S, Deas E, Ouberai M, Aprile FA, Arranz R, Ness S, Roodveldt C, Guilliams T, De-Genst EJ, Klenerman D, Wood NW, Knowles TP, Alfonso C, Rivas G, et al. Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation. Proceedings of the National Academy of Sciences of the United States of America. 112: E1994-2003. PMID 25855634 DOI: 10.1073/Pnas.1421204112 |
0.404 |
|
| 2015 |
Ivanov AP, Actis P, Jönsson P, Klenerman D, Korchev Y, Edel JB. On-demand delivery of single DNA molecules using nanopipets. Acs Nano. 9: 3587-95. PMID 25794527 DOI: 10.1021/Acsnano.5B00911 |
0.306 |
|
| 2015 |
Angelova PR, Horrocks MH, Klenerman D, Gandhi S, Abramov AY, Shchepinov MS. Lipid peroxidation is essential for α-synuclein-induced cell death. Journal of Neurochemistry. 133: 582-9. PMID 25580849 DOI: 10.1111/Jnc.13024 |
0.778 |
|
| 2015 |
Tsytlonok M, Ibrahim SM, Rowling PJ, Xu W, Ruedas-Rama MJ, Orte A, Klenerman D, Itzhaki LS. Single-molecule FRET reveals hidden complexity in a protein energy landscape. Structure (London, England : 1993). 23: 190-8. PMID 25565106 DOI: 10.1016/J.Str.2014.10.023 |
0.34 |
|
| 2014 |
Bell L, Seshia A, Lando D, Laue E, Palayret M, Lee SF, Klenerman D. A microfluidic device for the hydrodynamic immobilisation of living fission yeast cells for super-resolution imaging. Sensors and Actuators. B, Chemical. 192: 36-41. PMID 25844024 DOI: 10.1016/J.Snb.2013.10.002 |
0.646 |
|
| 2014 |
Ganzinger KA, Narayan P, Qamar SS, Weimann L, Ranasinghe RT, Aguzzi A, Dobson CM, McColl J, St George-Hyslop P, Klenerman D. Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)). Chembiochem : a European Journal of Chemical Biology. 15: 2515-21. PMID 25294384 DOI: 10.1002/Cbic.201402377 |
0.413 |
|
| 2014 |
Etheridge TJ, Boulineau RL, Herbert A, Watson AT, Daigaku Y, Tucker J, George S, Jönsson P, Palayret M, Lando D, Laue E, Osborne MA, Klenerman D, Lee SF, Carr AM. Quantification of DNA-associated proteins inside eukaryotic cells using single-molecule localization microscopy Nucleic Acids Research. 42: e146. PMID 25106872 DOI: 10.1093/Nar/Gku726 |
0.776 |
|
| 2014 |
Murphy RR, Danezis G, Horrocks MH, Jackson SE, Klenerman D. Bayesian inference of accurate population sizes and FRET efficiencies from single diffusing biomolecules. Analytical Chemistry. 86: 8603-12. PMID 25105347 DOI: 10.1021/Ac501188R |
0.75 |
|
| 2014 |
Narayan P, Holmström KM, Kim DH, Whitcomb DJ, Wilson MR, St George-Hyslop P, Wood NW, Dobson CM, Cho K, Abramov AY, Klenerman D. Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage. Biochemistry. 53: 2442-53. PMID 24717093 DOI: 10.1021/Bi401606F |
0.384 |
|
| 2014 |
Horrocks MH, Palayret M, Klenerman D, Lee SF. The changing point-spread function: single-molecule-based super-resolution imaging. Histochemistry and Cell Biology. 141: 577-85. PMID 24509806 DOI: 10.1007/S00418-014-1186-1 |
0.78 |
|
| 2014 |
Johansson B, Höök F, Klenerman D, Jönsson P. Label-free measurements of the diffusivity of molecules in lipid membranes. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 15: 486-91. PMID 24402971 DOI: 10.1002/Cphc.201301136 |
0.343 |
|
| 2014 |
Actis P, Tokar S, Clausmeyer J, Babakinejad B, Mikhaleva S, Cornut R, Takahashi Y, López Córdoba A, Novak P, Shevchuck AI, Dougan JA, Kazarian SG, Gorelkin PV, Erofeev AS, Yaminsky IV, ... ... Klenerman D, et al. Electrochemical nanoprobes for single-cell analysis. Acs Nano. 8: 875-84. PMID 24377306 DOI: 10.1021/Nn405612Q |
0.315 |
|
| 2014 |
Bell L, Seshia A, Lando D, Laue E, Palayret M, Lee SF, Klenerman D. A microfluidic device for the hydrodynamic immobilisation of living fission yeast cells for super-resolution imaging Sensors and Actuators, B: Chemical. 192: 36-41. DOI: 10.1016/j.snb.2013.10.002 |
0.592 |
|
| 2014 |
Korchev YE, Actis P, Tokar S, Novak P, Shevchuck A, Klenerman D, Sviderskaya EV. Nanopipet Based Nanoprobes for Single-Cell Analysis Biophysical Journal. 106: 798a-799a. DOI: 10.1016/J.Bpj.2013.11.4379 |
0.304 |
|
| 2014 |
Kundel F, Kjaergaard M, Shammas SL, Jackson SE, Klenerman D. Tau-Hsp70 Interaction at the Single-Molecule Level Biophysical Journal. 106: 59a. DOI: 10.1016/J.Bpj.2013.11.406 |
0.437 |
|
| 2014 |
Stroh PR, Ludtmann MH, Wood NW, Klenerman D, Gandhi S, Abramov AY. Alpha-Synuclein Modulates [Ca2+]c of Neurons and Astrocytes that Trigger Cell Death Biophysical Journal. 106: 529a. DOI: 10.1016/J.Bpj.2013.11.2951 |
0.332 |
|
| 2014 |
Actis P, Tokar S, Klenerman D, Korchev Y. Tailoring Nanoprobes for Single-Cell Surgery Biophysical Journal. 106: 414a. DOI: 10.1016/J.Bpj.2013.11.2332 |
0.332 |
|
| 2014 |
Tosatto L, Horrocks MH, Nunilo C, Guilliams T, Serra MD, Klenerman D. Single Molecule FRET Characterization of Oligomers from Alpha-Synuclein Early Onset Parkinson's Disease Mutants Biophysical Journal. 106: 269a. DOI: 10.1016/J.Bpj.2013.11.1575 |
0.784 |
|
| 2014 |
Horrocks MH, Lee SF, Gandhi S, Iljina M, Tosatto L, Dobson CM, Klenerman D. Single-Molecule Characterisation of Alpha-Synuclein Oligomers Biophysical Journal. 106: 268a. DOI: 10.1016/J.Bpj.2013.11.1573 |
0.818 |
|
| 2014 |
Armes H, Etheridge T, Herbert A, Lando D, Lee SF, Klenerman D, Carr A. Utilising Super-Resolution Palm Imaging in Fission Yeast Biophysical Journal. 106: 199a. DOI: 10.1016/J.Bpj.2013.11.1176 |
0.668 |
|
| 2014 |
Latty SL, Ganzinger KA, Hopkins LJ, Bryant C, Klenerman D. A Single-Molecule Study of Toll-Like Receptor 4 Structure and Signalling Biophysical Journal. 106: 196a. DOI: 10.1016/J.Bpj.2013.11.1158 |
0.304 |
|
| 2014 |
Klenerman D. Single Molecule Fluorescence Studies of Protein Aggregates and their role in Neurodegenerative Disease Biophysical Journal. 106: 6a. DOI: 10.1016/J.Bpj.2013.11.067 |
0.477 |
|
| 2013 |
Babakinejad B, Jönsson P, López Córdoba A, Actis P, Novak P, Takahashi Y, Shevchuk A, Anand U, Anand P, Drews A, Ferrer-Montiel A, Klenerman D, Korchev YE. Local delivery of molecules from a nanopipette for quantitative receptor mapping on live cells. Analytical Chemistry. 85: 9333-42. PMID 24004146 DOI: 10.1021/Ac4021769 |
0.304 |
|
| 2013 |
Shim JU, Ranasinghe RT, Smith CA, Ibrahim SM, Hollfelder F, Huck WT, Klenerman D, Abell C. Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays. Acs Nano. 7: 5955-64. PMID 23805985 DOI: 10.1021/Nn401661D |
0.3 |
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| 2013 |
Horrocks MH, Rajah L, Jönsson P, Kjaergaard M, Vendruscolo M, Knowles TP, Klenerman D. Single-molecule measurements of transient biomolecular complexes through microfluidic dilution. Analytical Chemistry. 85: 6855-9. PMID 23782428 DOI: 10.1021/Ac4010875 |
0.761 |
|
| 2013 |
Narayan P, Ganzinger KA, McColl J, Weimann L, Meehan S, Qamar S, Carver JA, Wilson MR, St George-Hyslop P, Dobson CM, Klenerman D. Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells. Journal of the American Chemical Society. 135: 1491-8. PMID 23339742 DOI: 10.1021/Ja3103567 |
0.41 |
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| 2013 |
Klenerman D, Shevchuk A, Novak P, Korchev YE, Davis SJ. Imaging the cell surface and its organization down to the level of single molecules. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20120027. PMID 23267181 DOI: 10.1098/Rstb.2012.0027 |
0.337 |
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| 2013 |
Kundel F, Kjaergaard M, Shammas S, Jackson S, Klenerman D. Tau-Hsp70 interaction on the single molecule level Molecular Neurodegeneration. 8: P61. DOI: 10.1186/1750-1326-8-S1-P61 |
0.425 |
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| 2013 |
Murphy RR, Danezis G, Jackson SE, Klenerman D. Accurate Intramolecular Distances by Single Molecule Confocal Spectroscopy: A Monte Carlo Markov Chain Analysis of Fluorescence Data from Freely Diffusing Biomolecules Biophysical Journal. 104: 174a. DOI: 10.1016/J.Bpj.2012.11.981 |
0.322 |
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| 2013 |
Ganzinger KA, Fernandes RA, McColl J, Lee SF, Palayret MG, Jönsson P, Davis SJ, Klenerman D. Single Molecule Studies of Key Processes during the Initiation of the Adaptive Immune Response Biophysical Journal. 104: 118a-119a. DOI: 10.1016/J.Bpj.2012.11.683 |
0.667 |
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| 2013 |
Palayret MG, Lee SF, Fernandes RA, Browne H, Davis SJ, Klenerman D. Applying Single Molecule Fluorescence Microscopy to Precisely Count Absolute Numbers of Proteins in Living Cells Biophysical Journal. 104: 525a-526a. DOI: 10.1016/J.Bpj.2012.11.2908 |
0.683 |
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| 2013 |
Weimann L, Lee SF, Felce JH, Davis SJ, Klenerman D. Revealing the Stoichiometry of G Protein-Coupled Receptors (GPCRs) at the Cell Surface using Single Molecule Imaging Biophysical Journal. 104: 525a. DOI: 10.1016/J.Bpj.2012.11.2904 |
0.645 |
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| 2013 |
Lee SF, Klenerman D, Ganzinger K, Chang V, McColl J, Palayret M. Super-Resolution Imaging of T Cell Triggering Supports the Kinetic Segregation Model in the Adaptive Immune Response Biophysical Journal. 104: 428a. DOI: 10.1016/J.Bpj.2012.11.2382 |
0.656 |
|
| 2013 |
Flint JA, Narayan P, Horrocks MH, Shammas SL, Kjaergaard M, Klenerman D. Single Molecule Fluorescence Studies of Amyloid Beta 1-42 Aggregation Biophysical Journal. 104: 359a-360a. DOI: 10.1016/J.Bpj.2012.11.1997 |
0.804 |
|
| 2012 |
Ye Y, Blaser G, Horrocks MH, Ruedas-Rama MJ, Ibrahim S, Zhukov AA, Orte A, Klenerman D, Jackson SE, Komander D. Ubiquitin chain conformation regulates recognition and activity of interacting proteins. Nature. 492: 266-70. PMID 23201676 DOI: 10.1038/Nature11722 |
0.762 |
|
| 2012 |
Narayan P, Meehan S, Carver JA, Wilson MR, Dobson CM, Klenerman D. Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones Biochemistry. 51: 9270-9276. PMID 23106396 DOI: 10.1021/Bi301277K |
0.412 |
|
| 2012 |
Lando D, Endesfelder U, Berger H, Subramanian L, Dunne PD, McColl J, Klenerman D, Carr AM, Sauer M, Allshire RC, Heilemann M, Laue ED. Quantitative single-molecule microscopy reveals that CENP-A(Cnp1) deposition occurs during G2 in fission yeast. Open Biology. 2: 120078. PMID 22870388 DOI: 10.1098/Rsob.120078 |
0.338 |
|
| 2012 |
Jönsson P, McColl J, Clarke RW, Ostanin VP, Jönsson B, Klenerman D. Hydrodynamic trapping of molecules in lipid bilayers. Proceedings of the National Academy of Sciences of the United States of America. 109: 10328-33. PMID 22699491 DOI: 10.1073/Pnas.1202858109 |
0.307 |
|
| 2012 |
Cremades N, Cohen SI, Deas E, Abramov AY, Chen AY, Orte A, Sandal M, Clarke RW, Dunne P, Aprile FA, Bertoncini CW, Wood NW, Knowles TP, Dobson CM, Klenerman D. Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell. 149: 1048-59. PMID 22632969 DOI: 10.1016/J.Cell.2012.03.037 |
0.437 |
|
| 2012 |
Shevchuk AI, Novak P, Taylor M, Diakonov IA, Ziyadeh-Isleem A, Bitoun M, Guicheney P, Lab MJ, Gorelik J, Merrifield CJ, Klenerman D, Korchev YE. An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy. The Journal of Cell Biology. 197: 499-508. PMID 22564416 DOI: 10.1083/Jcb.201109130 |
0.364 |
|
| 2012 |
Narayan P, Orte A, Clarke RW, Bolognesi B, Hook S, Ganzinger KA, Meehan S, Wilson MR, Dobson CM, Klenerman D. The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β 1-40 peptide Nature Structural and Molecular Biology. 19: 79-84. PMID 22179788 DOI: 10.1038/Nsmb.2191 |
0.421 |
|
| 2012 |
Horrocks MH, Li H, Shim JU, Ranasinghe RT, Clarke RW, Huck WT, Abell C, Klenerman D. Single molecule fluorescence under conditions of fast flow. Analytical Chemistry. 84: 179-85. PMID 22147688 DOI: 10.1021/Ac202313D |
0.761 |
|
| 2012 |
Horrocks MH, Cremades N, Tosatto L, Guilliams T, De Genst E, Shim J, Dobson CM, Klenerman D. Investigating the Factors Affecting the Aggregation of Alpha-Synuclein using Single Molecule Fluorescence and Fast Flow Microfluidics Biophysical Journal. 102: 255a. DOI: 10.1016/J.Bpj.2011.11.1407 |
0.801 |
|
| 2012 |
Narayan P, Ganzinger KA, McColl J, Drews A, Clarke RW, Qamar S, George-Hyslop PS, Klenerman D. Investigating the Interaction Between Characterized Amyloid-Beta Oligomers and the Prion Protein Receptor in Live Cells Biophysical Journal. 102: 243a. DOI: 10.1016/J.Bpj.2011.11.1339 |
0.402 |
|
| 2011 |
James JR, McColl J, Oliveira MI, Dunne PD, Huang E, Jansson A, Nilsson P, Sleep DL, Gonçalves CM, Morgan SH, Felce JH, Mahen R, Fernandes RA, Carmo AM, Klenerman D, et al. The T cell receptor triggering apparatus is composed of monovalent or monomeric proteins. The Journal of Biological Chemistry. 286: 31993-2001. PMID 21757710 DOI: 10.1074/Jbc.M111.219212 |
0.348 |
|
| 2011 |
Shevchuk AI, Novak P, Takahashi Y, Clarke R, Miragoli M, Babakinejad B, Gorelik J, Korchev YE, Klenerman D. Realizing the biological and biomedical potential of nanoscale imaging using a pipette probe. Nanomedicine (London, England). 6: 565-75. PMID 21542692 DOI: 10.2217/Nnm.10.154 |
0.363 |
|
| 2011 |
Klenerman D, Korchev YE, Davis SJ. Imaging and characterisation of the surface of live cells. Current Opinion in Chemical Biology. 15: 696-703. PMID 21536476 DOI: 10.1016/J.Cbpa.2011.04.001 |
0.345 |
|
| 2011 |
Miragoli M, Moshkov A, Novak P, Shevchuk A, Nikolaev VO, El-Hamamsy I, Potter CM, Wright P, Kadir SH, Lyon AR, Mitchell JA, Chester AH, Klenerman D, Lab MJ, Korchev YE, et al. Scanning ion conductance microscopy: a convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells. Journal of the Royal Society, Interface / the Royal Society. 8: 913-25. PMID 21325316 DOI: 10.1098/Rsif.2010.0597 |
0.331 |
|
| 2010 |
Orte A, Clarke R, Klenerman D. Single-molecule two-colour coincidence detection to probe biomolecular associations. Biochemical Society Transactions. 38: 914-8. PMID 20658976 DOI: 10.1042/Bst0380914 |
0.35 |
|
| 2010 |
Narayan P, Orte A, Dobson CM, Klenerman D. Detecting and Characterizing Amyloid-β1-40 Oligomers using Single Molecule Fluorescence Biophysical Journal. 98: 651a. DOI: 10.1016/J.Bpj.2009.12.3571 |
0.426 |
|
| 2010 |
Richards O, Johson N, Li C, Novak P, Clarke R, Korchev Y, Klenerman D. Probing the Interaction between a Nanopipette and a Soft Surface Using Scanning Ion Conductance Microscopy (SICM) Biophysical Journal. 98: 395a. DOI: 10.1016/J.Bpj.2009.12.2128 |
0.3 |
|
| 2009 |
Chiou A, Hägglöf P, Orte A, Chen AY, Dunne PD, Belorgey D, Karlsson-Li S, Lomas DA, Klenerman D. Probing neuroserpin polymerization and interaction with amyloid-beta peptides using single molecule fluorescence. Biophysical Journal. 97: 2306-15. PMID 19843463 DOI: 10.1016/J.Bpj.2009.07.057 |
0.327 |
|
| 2009 |
Dunne PD, Fernandes RA, McColl J, Yoon JW, James JR, Davis SJ, Klenerman D. DySCo: quantitating associations of membrane proteins using two-color single-molecule tracking. Biophysical Journal. 97: L5-7. PMID 19686638 DOI: 10.1016/J.Bpj.2009.05.046 |
0.354 |
|
| 2009 |
Novak P, Li C, Shevchuk AI, Stepanyan R, Caldwell M, Hughes S, Smart TG, Gorelik J, Ostanin VP, Lab MJ, Moss GW, Frolenkov GI, Klenerman D, Korchev YE. Nanoscale live-cell imaging using hopping probe ion conductance microscopy. Nature Methods. 6: 279-81. PMID 19252505 DOI: 10.1038/Nmeth.1306 |
0.31 |
|
| 2009 |
Ibrahim S, Blaser G, Orte A, Jackson S, Klenerman D. Single Molecule Studies Of Ubiquitin Unfolding Biophysical Journal. 96: 555a. DOI: 10.1016/J.Bpj.2008.12.3645 |
0.357 |
|
| 2009 |
Novak P, Li C, Shevchuk A, Stepanyan R, Caldwell M, Hughes S, Smart T, Gorelik J, Lab M, Moss G, Frolenkov G, Klenerman D, Korchev Y. Next Generation SICM Allows Nanoscale Imaging Of Biological Processes In Real-time Biophysical Journal. 96: 374a. DOI: 10.1016/J.Bpj.2008.12.2811 |
0.35 |
|
| 2009 |
Dunne PD, Howes EA, James PS, Bruckbauer A, Jones R, Klenerman D. Probing Membrane Domains and Diffusion Barriers in Live Sperm Cells Using Fluorescent Particle Tracking Biophysical Journal. 96: 451a. DOI: 10.1016/J.Bpj.2008.12.2318 |
0.33 |
|
| 2009 |
McColl JT, Alexandre R, James JR, Dunne PD, Yoon JW, Davis SJ, Klenerman D. Dynamic Single-molecule Colocalization Imaging - A New Method For Examining Membrane Protein Association In Living Cells Biophysical Journal. 96: 25a. DOI: 10.1016/J.Bpj.2008.12.019 |
0.374 |
|
| 2008 |
Gorelik J, Ali NN, Sheikh Abdul Kadir SH, Lab M, Stojkovic P, Armstrong L, Sviderskaya EV, Negulyaev YA, Klenerman D, Bennett DC, Lako M, Harding SE, Stojkovic M, Korchev YE. Non-invasive imaging of stem cells by scanning ion conductance microscopy: future perspective. Tissue Engineering. Part C, Methods. 14: 311-8. PMID 19055357 DOI: 10.1089/Ten.Tec.2008.0058 |
0.311 |
|
| 2008 |
Bentley DR, Balasubramanian S, Swerdlow HP, Smith GP, Milton J, Brown CG, Hall KP, Evers DJ, Barnes CL, Bignell HR, Boutell JM, Bryant J, Carter RJ, Keira Cheetham R, Cox AJ, ... ... Klenerman D, et al. Accurate whole human genome sequencing using reversible terminator chemistry. Nature. 456: 53-9. PMID 18987734 DOI: 10.1038/Nature07517 |
0.62 |
|
| 2008 |
Orte A, Clarke RW, Klenerman D. Fluorescence coincidence spectroscopy for single-molecule fluorescence resonance energy-transfer measurements. Analytical Chemistry. 80: 8389-97. PMID 18855410 DOI: 10.1021/Ac8009092 |
0.331 |
|
| 2008 |
Orte A, Birkett NR, Clarke RW, Devlin GL, Dobson CM, Klenerman D. Direct characterization of amyloidogenic oligomers by single-molecule fluorescence. Proceedings of the National Academy of Sciences of the United States of America. 105: 14424-9. PMID 18796612 DOI: 10.1073/Pnas.0803086105 |
0.421 |
|
| 2008 |
Orte A, Craggs TD, White SS, Jackson SE, Klenerman D. Evidence of an intermediate and parallel pathways in protein unfolding from single-molecule fluorescence Journal of the American Chemical Society. 130: 7898-7907. PMID 18507381 DOI: 10.1021/Ja709973M |
0.382 |
|
| 2008 |
Alves D, Li H, Codrington R, Orte A, Ren X, Klenerman D, Balasubramanian S. Single-molecule analysis of human telomerase monomer. Nature Chemical Biology. 4: 287-9. PMID 18391947 DOI: 10.1038/Nchembio.82 |
0.321 |
|
| 2008 |
Yoon JW, Bruckbauer A, Fitzgerald WJ, Klenerman D. Bayesian inference for improved single molecule fluorescence tracking. Biophysical Journal. 94: 4932-47. PMID 18339757 DOI: 10.1529/Biophysj.107.116285 |
0.332 |
|
| 2008 |
Shevchuk AI, Hobson P, Lab MJ, Klenerman D, Krauzewicz N, Korchev YE. Imaging single virus particles on the surface of cell membranes by high-resolution scanning surface confocal microscopy. Biophysical Journal. 94: 4089-94. PMID 18199668 DOI: 10.1529/Biophysj.107.112524 |
0.336 |
|
| 2008 |
Shevchuk AI, Hobson P, Lab MJ, Klenerman D, Krauzewicz N, Korchev YE. Endocytic pathways: combined scanning ion conductance and surface confocal microscopy study. PflüGers Archiv : European Journal of Physiology. 456: 227-35. PMID 18180951 DOI: 10.1007/S00424-007-0410-4 |
0.362 |
|
| 2008 |
Li C, Johnson N, Ostanin V, Shevchuk A, Ying L, Korchev Y, Klenerman D. High resolution imaging using scanning ion conductance microscopy with improved distance feedback control Progress in Natural Science. 18: 671-677. DOI: 10.1016/J.Pnsc.2008.01.011 |
0.308 |
|
| 2007 |
James JR, White SS, Clarke RW, Johansen AM, Dunne PD, Sleep DL, Fitzgerald WJ, Davis SJ, Klenerman D. Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 17662-7. PMID 17971442 DOI: 10.1073/Pnas.0700411104 |
0.318 |
|
| 2007 |
Bruckbauer A, James P, Zhou D, Yoon JW, Excell D, Korchev Y, Jones R, Klenerman D. Nanopipette delivery of individual molecules to cellular compartments for single-molecule fluorescence tracking. Biophysical Journal. 93: 3120-31. PMID 17631532 DOI: 10.1529/Biophysj.107.104737 |
0.336 |
|
| 2007 |
Clarke RW, Monnier N, Li H, Zhou D, Browne H, Klenerman D. Two-color fluorescence analysis of individual virions determines the distribution of the copy number of proteins in herpes simplex virus particles. Biophysical Journal. 93: 1329-37. PMID 17513380 DOI: 10.1529/Biophysj.107.106351 |
0.323 |
|
| 2007 |
Clarke RW, Orte A, Klenerman D. Optimized threshold selection for single-molecule two-color fluorescence coincidence spectroscopy. Analytical Chemistry. 79: 2771-7. PMID 17343363 DOI: 10.1021/Ac062188W |
0.304 |
|
| 2006 |
Klenerman D, Korchev Y. Potential biomedical applications of the scanned nanopipette. Nanomedicine (London, England). 1: 107-14. PMID 17716213 DOI: 10.2217/17435889.1.1.107 |
0.344 |
|
| 2006 |
Orte A, Clarke R, Balasubramanian S, Klenerman D. Determination of the fraction and stoichiometry of femtomolar levels of biomolecular complexes in an excess of monomer using single-molecule, two-color coincidence detection. Analytical Chemistry. 78: 7707-15. PMID 17105162 DOI: 10.1021/Ac061122Y |
0.301 |
|
| 2006 |
Ren X, Li H, Clarke RW, Alves DA, Ying L, Klenerman D, Balasubramanian S. Analysis of human telomerase activity and function by two color single molecule coincidence fluorescence spectroscopy. Journal of the American Chemical Society. 128: 4992-5000. PMID 16608333 DOI: 10.1021/Ja056613Z |
0.307 |
|
| 2006 |
Manzanera M, Frankel DJ, Li H, Zhou D, Bruckbauer A, Kreutzmann P, Blackburn JM, Abell C, Rayment T, Klenerman D, Barker PD. Macroscopic 2D networks self-assembled from nanometer-sized protein/DNA complexes. Nano Letters. 6: 365-70. PMID 16522024 DOI: 10.1021/Nl051599+ |
0.707 |
|
| 2006 |
Shevchuk AI, Frolenkov GI, Sánchez D, James PS, Freedman N, Lab MJ, Jones R, Klenerman D, Korchev YE. Imaging proteins in membranes of living cells by high-resolution scanning ion conductance microscopy. Angewandte Chemie (International Ed. in English). 45: 2212-6. PMID 16506257 DOI: 10.1002/Anie.200503915 |
0.307 |
|
| 2006 |
Whiten DR, Brownjohn PW, Moore S, De S, Zuo Y, Livesey R, Klenerman D. P2-176: PROTEIN AGGREGATION AND NEUROINFLAMMATION ARE INTERRELATED IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P736-P736. DOI: 10.1016/J.Jalz.2018.06.863 |
0.705 |
|
| 2006 |
Klenerman D, Kundel F, Falcon B, Knowles T, Goedert M, Hong L, McEwan W, Meisl G. O3-01-05: IN VITRO MEASUREMENTS OF TAU AGGREGATE ELONGATION AND FRAGMENTATION RATES ALLOW THE MODELLING OF PRION-LIKE SPREADING IN HUMANS Alzheimer's & Dementia. 14: P1009-P1010. DOI: 10.1016/J.Jalz.2018.06.2774 |
0.313 |
|
| 2006 |
De S, Klenerman D. O1-01-01: CHARACTERIZING PROTEIN AGGREGATES FROM THE HUMAN BRAIN Alzheimer's & Dementia. 14: P212-P212. DOI: 10.1016/J.Jalz.2018.06.2330 |
0.675 |
|
| 2005 |
Ying L, Bruckbauer A, Zhou D, Gorelik J, Shevchuk A, Lab M, Korchev Y, Klenerman D. The scanned nanopipette: a new tool for high resolution bioimaging and controlled deposition of biomolecules. Physical Chemistry Chemical Physics : Pccp. 7: 2859-66. PMID 16189604 DOI: 10.1039/B506743J |
0.301 |
|
| 2004 |
Li H, Ying L, Ren X, Balasubramanian S, Klenerman D. Fluorescence studies of single biomolecules. Biochemical Society Transactions. 32: 753-6. PMID 15494006 DOI: 10.1042/Bst0320753 |
0.326 |
|
| 2004 |
Li H, Ren X, Ying L, Balasubramanian S, Klenerman D. Measuring single-molecule nucleic acid dynamics in solution by two-color filtered ratiometric fluorescence correlation spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 101: 14425-30. PMID 15452356 DOI: 10.1073/Pnas.0404295101 |
0.307 |
|
| 2004 |
Li H, Zhou D, Browne H, Balasubramanian S, Klenerman D. Molecule by molecule direct and quantitative counting of antibody-protein complexes in solution. Analytical Chemistry. 76: 4446-51. PMID 15283586 DOI: 10.1021/Ac049512C |
0.322 |
|
| 2003 |
Ying L, Green JJ, Li H, Klenerman D, Balasubramanian S. Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer. Proceedings of the National Academy of Sciences of the United States of America. 100: 14629-34. PMID 14645716 DOI: 10.1073/Pnas.2433350100 |
0.309 |
|
| 2003 |
Gorelik J, Shevchuk AI, Frolenkov GI, Diakonov IA, Lab MJ, Kros CJ, Richardson GP, Vodyanoy I, Edwards CR, Klenerman D, Korchev YE. Dynamic assembly of surface structures in living cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 5819-22. PMID 12721367 DOI: 10.1073/Pnas.1030502100 |
0.32 |
|
| 2003 |
Li H, Ying L, Green JJ, Balasubramanian S, Klenerman D. Ultrasensitive coincidence fluorescence detection of single DNA molecules. Analytical Chemistry. 75: 1664-70. PMID 12705600 DOI: 10.1021/Ac026367Z |
0.304 |
|
| 2003 |
Rothery AM, Gorelik J, Bruckbauer A, Yu W, Korchev YE, Klenerman D. A novel light source for SICM-SNOM of living cells Journal of Microscopy. 209: 94-101. PMID 12588526 DOI: 10.1046/J.1365-2818.2003.01122.X |
0.313 |
|
| 2002 |
Gorelik J, Shevchuk A, Ramalho M, Elliott M, Lei C, Higgins CF, Lab MJ, Klenerman D, Krauzewicz N, Korchev Y. Scanning surface confocal microscopy for simultaneous topographical and fluorescence imaging: Application to single virus-like particle entry into a cell Proceedings of the National Academy of Sciences of the United States of America. 99: 16018-16023. PMID 12466501 DOI: 10.1073/Pnas.252458399 |
0.342 |
|
| 2002 |
Bruckbauer A, Ying L, Rothery AM, Zhou D, Shevchuk AI, Abell C, Korchev YE, Klenerman D. Writing with DNA and protein using a nanopipet for controlled delivery. Journal of the American Chemical Society. 124: 8810-1. PMID 12137530 DOI: 10.1021/Ja026816C |
0.304 |
|
| 2001 |
Osborne MA, Barnes CL, Balasubramanian S, Klenerman D. Probing DNA Surface Attachment and Local Environment Using Single Molecule Spectroscopy Journal of Physical Chemistry B. 105: 3120-3126. DOI: 10.1021/Jp0038660 |
0.323 |
|
| 2001 |
Osborne MA, Barnes CL, Balasubramanian S, Klenerman D. Probing DNA surface attachment and local environment using single molecule spectroscopy Journal of Physical Chemistry B. 105: 3120-3126. |
0.614 |
|
| 2000 |
Osborne MA, Furey WS, Klenerman D, Balasubramanian S. Single-molecule analysis of DNA immobilized on microspheres. Analytical Chemistry. 72: 3678-81. PMID 10952560 DOI: 10.1021/Ac000129R |
0.667 |
|
| 1998 |
Furey WS, Joyce CM, Osborne MA, Klenerman D, Peliska JA, Balasubramanian S. Use of fluorescence resonance energy transfer to investigate the conformation of DNA substrates bound to the Klenow fragment. Biochemistry. 37: 2979-90. PMID 9485450 DOI: 10.1021/bi9719758 |
0.623 |
|
| 1998 |
Osborne MA, Balasubramanian S, Furey WS, Klenerman D. Optically biased diffusion of single molecules studied by confocal fluorescence microscopy Journal of Physical Chemistry B. 102: 3160-3167. |
0.621 |
|
| 1988 |
Crofton MW, Stevens CG, Klenerman D, Gutow JH, Zare RN. Overtone spectra of C–H oscillators in cold molecules Journal of Chemical Physics. 89: 7100-7111. DOI: 10.1063/1.455289 |
0.368 |
|
| 1988 |
Gutow JH, Klenerman D, Zare RN. Comparison of overtone-induced and electronic photochemistry of liquid tert-butyl hydroperoxide: supporting evidence for vibrational mode selectivity The Journal of Physical Chemistry. 92: 172-177. DOI: 10.1021/J100312A037 |
0.376 |
|
| 1986 |
Klenerman D, Zare RN. How effective is internal excitation in promoting the HCl + 1,3-butadiene addition reaction? Chemical Physics Letters. 130: 190-194. DOI: 10.1016/0009-2614(86)80452-3 |
0.382 |
|
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