| Year |
Citation |
Score |
| 2014 |
Kaushansky A, Kaushansky K. Systems biology of megakaryocytes. Advances in Experimental Medicine and Biology. 844: 59-84. PMID 25480637 DOI: 10.1007/978-1-4939-2095-2_4 |
0.413 |
|
| 2014 |
Sangkhae V, Saur SJ, Kaushansky A, Kaushansky K, Hitchcock IS. Phosphorylated c-Mpl tyrosine 591 regulates thrombopoietin-induced signaling. Experimental Hematology. 42: 477-86.e4. PMID 24607955 DOI: 10.1016/J.Exphem.2014.02.007 |
0.315 |
|
| 2014 |
Hitchcock IS, Kaushansky K. Thrombopoietin from beginning to end. British Journal of Haematology. 165: 259-68. PMID 24499199 DOI: 10.1111/bjh.12772 |
0.302 |
|
| 2011 |
Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes & Development. 25: 1426-38. PMID 21724834 DOI: 10.1101/Gad.2024411 |
0.36 |
|
| 2011 |
Jung AS, Kaushansky A, Macbeath G, Kaushansky K. Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling. Cell Cycle (Georgetown, Tex.). 10: 1838-44. PMID 21527831 DOI: 10.4161/Cc.10.11.15776 |
0.329 |
|
| 2010 |
Saur SJ, Sangkhae V, Geddis AE, Kaushansky K, Hitchcock IS. Ubiquitination and degradation of the thrombopoietin receptor c-Mpl. Blood. 115: 1254-63. PMID 19880496 DOI: 10.1182/Blood-2009-06-227033 |
0.398 |
|
| 2010 |
Kaushansky K. Myeloproliferative diseases: it’s beginning to make sense Pathology. 42. DOI: 10.3109/00313021003600648 |
0.404 |
|
| 2010 |
Kaushansky K. Thrombopoietin: from cloning to clinic Pathology. 42: S39. DOI: 10.1097/01268031-201042001-00076 |
0.351 |
|
| 2009 |
Kaushansky K. Determinants of platelet number and regulation of thrombopoiesis. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 147-52. PMID 20008193 DOI: 10.1182/Asheducation-2009.1.147 |
0.425 |
|
| 2009 |
Kaushansky K, Ranney HM. Thrombopoietin in normal and neoplastic stem cell development. Best Practice & Research. Clinical Haematology. 22: 495-9. PMID 19959099 DOI: 10.1016/J.Beha.2009.08.004 |
0.415 |
|
| 2009 |
Kaushansky K. Molecular mechanisms of thrombopoietin signaling Journal of Thrombosis and Haemostasis. 7: 235-238. PMID 19630807 DOI: 10.1111/J.1538-7836.2009.03419.X |
0.416 |
|
| 2009 |
Jung AS, Kaushansky A, Kaushansky K. Functional Interaction Between c-MPL and Tensin2: A Novel and Potentially Important Pathway in Thrombopoietin Mediated Signaling. Blood. 114: 3609-3609. DOI: 10.1182/Blood.V114.22.3609.3609 |
0.448 |
|
| 2008 |
Soda M, Willert K, Kaushansky K, Geddis AE. Inhibition of GSK-3beta promotes survival and proliferation of megakaryocytic cells through a beta-catenin-independent pathway. Cellular Signalling. 20: 2317-23. PMID 18804163 DOI: 10.1016/J.Cellsig.2008.09.001 |
0.304 |
|
| 2008 |
Hitchcock IS, Chen MM, King JR, Kaushansky K. YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation. Blood. 112: 2222-31. PMID 18487512 DOI: 10.1182/Blood-2008-01-134049 |
0.405 |
|
| 2008 |
Kaushansky K. Cell expansion and maintenance of stemness. Blood. 111: 3920-1. PMID 18434969 DOI: 10.1182/Blood-2008-01-134619 |
0.343 |
|
| 2008 |
McIntosh B, Kaushansky K. Transcriptional regulation of bone marrow thrombopoietin by platelet proteins. Experimental Hematology. 36: 799-806. PMID 18410987 DOI: 10.1016/J.Exphem.2008.02.012 |
0.36 |
|
| 2008 |
Nakao T, Geddis AE, Fox NE, Kaushansky K. PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1). Cell Cycle (Georgetown, Tex.). 7: 257-66. PMID 18256550 DOI: 10.1182/Blood.V106.11.202.202 |
0.383 |
|
| 2008 |
Kaushansky K. Historical review: megakaryopoiesis and thrombopoiesis. Blood. 111: 981-6. PMID 18223171 DOI: 10.1182/Blood-2007-05-088500 |
0.403 |
|
| 2008 |
Hitchcock IS, Fox NE, Prévost N, Sear K, Shattil SJ, Kaushansky K. Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout. Blood. 111: 596-604. PMID 17925492 DOI: 10.1182/Blood-2007-05-089680 |
0.395 |
|
| 2008 |
Persico J, Budjahardo I, Kaushansky K. The Homodimeric Hematopoietic Cytokine Receptor C-Mpl Requires Cross Phosphorylation in Order to Signal Cell Proliferation Blood. 112: 3734-3734. DOI: 10.1182/Blood.V112.11.3734.3734 |
0.457 |
|
| 2008 |
Saur SJ, Geddis A, Kaushansky K, Hitchcock I. Thrombopoietin-Mediated Ubiquitination and Degradation of C-Mpl Blood. 112: 2889-2889. DOI: 10.1182/Blood.V112.11.2889.2889 |
0.392 |
|
| 2008 |
Fox NE, Chen R, Hitchcock I, Kaushansky K, Geddis A. Erythropoietin Stimulates Thrombopoiesis in the Absence of C-Mpl Signaling Blood. 112: 2451-2451. DOI: 10.1182/Blood.V112.11.2451.2451 |
0.391 |
|
| 2007 |
Hitchcock IS, Kaushansky K. Thrombopoietin promotes beta1-integrin-mediated adhesion in hematopoietic cells via the small GTPase Rapl. Experimental Hematology. 35: 793-801. PMID 17577928 DOI: 10.1016/J.Exphem.2007.02.005 |
0.402 |
|
| 2007 |
Kaushansky K. The chronic myeloproliferative disorders and mutation of JAK2: Dameshek's 54 year old speculation comes of age. Best Practice & Research. Clinical Haematology. 20: 5-12. PMID 17336249 DOI: 10.1016/J.Beha.2006.11.005 |
0.337 |
|
| 2007 |
Geddis AE, Fox NE, Tkachenko E, Kaushansky K. Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression. Cell Cycle (Georgetown, Tex.). 6: 455-60. PMID 17312391 DOI: 10.4161/Cc.6.4.3836 |
0.321 |
|
| 2006 |
Kaushansky K. Hematopoietic growth factors, signaling and the chronic myeloproliferative disorders. Cytokine & Growth Factor Reviews. 17: 423-30. PMID 17055768 DOI: 10.1016/J.Cytogfr.2006.09.005 |
0.358 |
|
| 2006 |
Coleman TR, Westenfelder C, Tögel FE, Yang Y, Hu Z, Swenson L, Leuvenink HG, Ploeg RJ, d'Uscio LV, Katusic ZS, Ghezzi P, Zanetti A, Kaushansky K, Fox NE, Cerami A, et al. Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities. Proceedings of the National Academy of Sciences of the United States of America. 103: 5965-70. PMID 16585502 DOI: 10.1073/Pnas.0601377103 |
0.315 |
|
| 2006 |
Kirito K, Kaushansky K. Transcriptional regulation of megakaryopoiesis: thrombopoietin signaling and nuclear factors. Current Opinion in Hematology. 13: 151-6. PMID 16567958 DOI: 10.1097/01.Moh.0000219660.03657.4B |
0.306 |
|
| 2006 |
Geddis AE, Kaushansky K. Endomitotic megakaryocytes form a midzone in anaphase but have a deficiency in cleavage furrow formation. Cell Cycle (Georgetown, Tex.). 5: 538-45. PMID 16552179 DOI: 10.4161/Cc.5.5.2537 |
0.353 |
|
| 2006 |
Geddis AE, Fox NE, Kaushansky K. The Mpl receptor expressed on endothelial cells does not contribute significantly to the regulation of circulating thrombopoietin levels. Experimental Hematology. 34: 82-6. PMID 16413394 DOI: 10.1016/J.Exphem.2005.09.008 |
0.386 |
|
| 2006 |
Chanprasert S, Geddis AE, Barroga C, Fox NE, Kaushansky K. Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes. Cellular Signalling. 18: 1212-8. PMID 16380230 DOI: 10.1016/J.Cellsig.2005.09.010 |
0.399 |
|
| 2006 |
Geron I, Barroga C, Gotlib J, Kavalerchik E, Abrahamsson A, Goff D, Cacalano N, Hood J, Soll R, Noronha G, Tefferi A, Weissman IL, Kaushansky K, Jamieson C. Inhibition of JAK2 V617F-Induced Erythroid Skewing of Hematopoietic Stem Cell Differentiation with a Selective JAK2 Antagonist. Blood. 108: 3616-3616. DOI: 10.1182/Blood.V108.11.3616.3616 |
0.361 |
|
| 2006 |
Hitchcock IS, Fox NE, Sear K, Tiedt R, Skoda R, Kaushansky K. Focal Adhesion Kinase in Megakaryopoiesis: A Study of Megakaryocyte-Specific FAK Deletion. Blood. 108: 354-354. DOI: 10.1182/Blood.V108.11.354.354 |
0.433 |
|
| 2006 |
Hitchcock IS, Kaushansky K. Thrombopoietin Promotes b1 Integrin-Mediated Adhesion in Hematopoietic Cells Via the Small GTPase Rap1. Blood. 108: 1393-1393. DOI: 10.1182/Blood.V108.11.1393.1393 |
0.442 |
|
| 2006 |
Geddis A, Fox N, Sear K, Tkachenko E, Kaushansky K. Endomitotic MKs Undergo Cortical Contraction during Anaphase but Do Not Complete Furrow Ingression. Blood. 108: 1124-1124. DOI: 10.1182/Blood.V108.11.1124.1124 |
0.333 |
|
| 2005 |
Kaushansky K. The molecular mechanisms that control thrombopoiesis. The Journal of Clinical Investigation. 115: 3339-47. PMID 16322778 DOI: 10.1172/Jci26674 |
0.39 |
|
| 2005 |
Kaushansky K. On the molecular origins of the chronic myeloproliferative disorders: it all makes sense. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 533-7. PMID 16304432 DOI: 10.1182/Asheducation-2005.1.533 |
0.424 |
|
| 2005 |
Kirito K, Kaushansky K. Thrombopoietin stimulates vascular endothelial cell growth factor (VEGF) production in hematopoietic stem cells. Cell Cycle (Georgetown, Tex.). 4: 1729-31. PMID 16258288 DOI: 10.4161/Cc.4.12.2197 |
0.398 |
|
| 2005 |
Kaushansky K. Thrombopoietin and the hematopoietic stem cell. Annals of the New York Academy of Sciences. 1044: 139-41. PMID 15958707 DOI: 10.1182/Blood.V92.1.1.413A37_1_3 |
0.364 |
|
| 2005 |
Kirito K, Fox N, Komatsu N, Kaushansky K. Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1alpha. Blood. 105: 4258-63. PMID 15705785 DOI: 10.1182/Blood-2004-07-2712 |
0.377 |
|
| 2005 |
Fox NE, Kaushansky K. Engagement of integrin alpha4beta1 enhances thrombopoietin-induced megakaryopoiesis. Experimental Hematology. 33: 94-9. PMID 15661402 DOI: 10.1016/J.Exphem.2004.10.002 |
0.382 |
|
| 2005 |
Yoshida K, Kirito K, Kaushansky K, Komatsu N. Thrombopoietin (TPO) Regulates HIF-1α Level through Generation of Mitochondrial Reactive Oxygen Species (ROS). Blood. 106: 3145-3145. DOI: 10.1182/Blood.V106.11.3145.3145 |
0.332 |
|
| 2004 |
Kirito K, Fox N, Kaushansky K. Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells. Molecular and Cellular Biology. 24: 6751-62. PMID 15254242 DOI: 10.1128/Mcb.24.15.6751-6762.2004 |
0.427 |
|
| 2004 |
Geddis AE, Kaushansky K. Megakaryocytes express functional Aurora-B kinase in endomitosis. Blood. 104: 1017-24. PMID 15130946 DOI: 10.1182/Blood-2004-02-0419 |
0.323 |
|
| 2004 |
Geddis AE, Fox NE, Kaushansky K. The C-Mpl Receptor Expressed on Endothelial Cells Does Not Contribute Significantly to the Regulation of Circulating Thrombopoietin (TPO) Levels. Blood. 104: 739-739. DOI: 10.1182/Blood.V104.11.739.739 |
0.4 |
|
| 2004 |
McIntosh BJ, Fox NE, Kaushansky K. Factors Affecting Thrombopoietin Production from Bone Marrow Stromal Cells. Blood. 104: 1280-1280. DOI: 10.1182/Blood.V104.11.1280.1280 |
0.408 |
|
| 2004 |
Geddis AE, Kaushansky K. Aurora-B Kinase Translocates to the Midzone in Endomitotic Megakaryocytes. Blood. 104: 1263-1263. DOI: 10.1182/Blood.V104.11.1263.1263 |
0.336 |
|
| 2003 |
Habib T, Nelson A, Kaushansky K. IL-21: a novel IL-2-family lymphokine that modulates B, T, and natural killer cell responses. The Journal of Allergy and Clinical Immunology. 112: 1033-45. PMID 14657853 DOI: 10.1016/J.Jaci.2003.08.039 |
0.735 |
|
| 2003 |
Kaushansky K. Thrombopoietin: A tool for understanding thrombopoiesis Journal of Thrombosis and Haemostasis. 1: 1587-1592. PMID 12871295 DOI: 10.1046/J.1538-7836.2003.00273.X |
0.402 |
|
| 2003 |
Kirito K, Fox N, Kaushansky K. Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells. Blood. 102: 3172-8. PMID 12855555 DOI: 10.1182/Blood-2003-03-0944 |
0.441 |
|
| 2003 |
Kaushansky K. Thrombopoietin: accumulating evidence for an important biological effect on the hematopoietic stem cell. Annals of the New York Academy of Sciences. 996: 39-43. PMID 12799280 DOI: 10.1111/J.1749-6632.2003.Tb03230.X |
0.38 |
|
| 2003 |
Kyriakides TR, Rojnuckarin P, Reidy MA, Hankenson KD, Papayannopoulou T, Kaushansky K, Bornstein P. Megakaryocytes require thrombospondin-2 for normal platelet formation and function. Blood. 101: 3915-23. PMID 12732502 DOI: 10.1182/Blood.V101.10.3915 |
0.594 |
|
| 2003 |
Kaushansky K. Etiology of the myeloproliferative disorders: the role of thrombopoietin. Seminars in Hematology. 40: 6-9. PMID 12682875 DOI: 10.1053/Shem.2003.50027 |
0.391 |
|
| 2002 |
Kaushansky K. Thrombopoietin: from theory to reality. International Journal of Hematology. 76: 343-5. PMID 12430879 DOI: 10.1007/Bf03165282 |
0.453 |
|
| 2002 |
Fox N, Priestley G, Papayannopoulou T, Kaushansky K. Thrombopoietin expands hematopoietic stem cells after transplantation. The Journal of Clinical Investigation. 110: 389-94. PMID 12163458 DOI: 10.1172/Jci15430 |
0.31 |
|
| 2002 |
Linden HM, Kaushansky K. The glycan domain of thrombopoietin (TPO) acts in trans to enhance secretion of the hormone and other cytokines. The Journal of Biological Chemistry. 277: 35240-7. PMID 12101178 DOI: 10.1074/Jbc.M201297200 |
0.382 |
|
| 2002 |
Habib T, Senadheera S, Weinberg K, Kaushansky K. The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3. Biochemistry. 41: 8725-31. PMID 12093291 DOI: 10.1021/Bi0202023 |
0.741 |
|
| 2002 |
Kaushansky K, Drachman JG. The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production. Oncogene. 21: 3359-67. PMID 12032774 DOI: 10.1038/Sj.Onc.1205323 |
0.374 |
|
| 2002 |
Kaushansky K, Fox N, Lin NL, Liles WC. Lineage-specific growth factors can compensate for stem and progenitor cell deficiencies at the postprogenitor cell level: an analysis of doubly TPO- and G-CSF receptor-deficient mice. Blood. 99: 3573-8. PMID 11986210 DOI: 10.1182/Blood.V99.10.3573 |
0.324 |
|
| 2002 |
Drachman JG, Miyakawa Y, Luthi JN, Dahlen DD, Raney A, Geddis AE, Kaushansky K. Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation. The Journal of Biological Chemistry. 277: 23544-53. PMID 11980901 DOI: 10.1074/Jbc.M201120200 |
0.426 |
|
| 2002 |
Zhao S, Zoller K, Masuko M, Rojnuckarin P, Yang XO, Parganas E, Kaushansky K, Ihle JN, Papayannopoulou T, Willerford DM, Clackson T, Blau CA. JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells. The Embo Journal. 21: 2159-67. PMID 11980713 DOI: 10.1093/Emboj/21.9.2159 |
0.62 |
|
| 2002 |
Kaushansky K. Mpl and the hematopoietic stem cell Leukemia. 16: 738-739. PMID 11960358 DOI: 10.1038/Sj.Leu.2402398 |
0.306 |
|
| 2002 |
Geddis AE, Linden HM, Kaushansky K. Thrombopoietin: a pan-hematopoietic cytokine. Cytokine & Growth Factor Reviews. 13: 61-73. PMID 11750880 DOI: 10.1016/S1359-6101(01)00030-2 |
0.456 |
|
| 2001 |
Rojnuckarin P, Miyakawa Y, Fox NE, Deou J, Daum G, Kaushansky K. The roles of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes. The Journal of Biological Chemistry. 276: 41014-22. PMID 11535599 DOI: 10.1074/Jbc.M106508200 |
0.637 |
|
| 2001 |
Carow CE, Fox NE, Kaushansky K. Kinetics of endomitosis in primary murine megakaryocytes Journal of Cellular Physiology. 188: 291-303. PMID 11473355 DOI: 10.1002/Jcp.1120 |
0.332 |
|
| 2001 |
Kaushansky K. Hematopoietic growth factor mimetics Annals of the New York Academy of Sciences. 938: 131-138. PMID 11458500 DOI: 10.1111/J.1749-6632.2001.Tb03582.X |
0.356 |
|
| 2001 |
Geddis AE, Fox NE, Kaushansky K. Phosphatidylinositol 3-Kinase Is Necessary but Not Sufficient for Thrombopoietin-induced Proliferation in Engineered Mpl-bearing Cell Lines as Well as in Primary Megakaryocytic Progenitors Journal of Biological Chemistry. 276: 34473-34479. PMID 11418622 DOI: 10.1074/jbc.M105178200 |
0.302 |
|
| 2001 |
Rojnuckarin P, Kaushansky K. Actin reorganization and proplatelet formation in murine megakaryocytes: the role of protein kinase calpha. Blood. 97: 154-61. PMID 11133755 DOI: 10.1182/Blood.V97.1.154 |
0.63 |
|
| 2001 |
Kaushansky K. CAMT: new findings and new questions Blood. 97: 1-2. PMID 11133735 DOI: 10.1182/Blood.V97.1.1 |
0.31 |
|
| 2001 |
Miyakawa Y, Rojnuckarin P, Habib T, Kaushansky K. Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes. The Journal of Biological Chemistry. 276: 2494-502. PMID 11054408 DOI: 10.1074/Jbc.M002633200 |
0.773 |
|
| 2000 |
Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, ... ... Kaushansky K, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function Nature. 408: 57-63. PMID 11081504 DOI: 10.1038/35040504 |
0.412 |
|
| 2000 |
Wang Q, Miyakawa Y, Fox N, Kaushansky K. Interferon-α directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1 Blood. 96: 2093-2099. PMID 10979953 DOI: 10.1182/Blood.V96.6.2093.H8002093_2093_2099 |
0.379 |
|
| 2000 |
Miyakawa Y, Drachman JG, Gallis B, Kaushansky A, Kaushansky K. A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-Mpl Journal of Biological Chemistry. 275: 32214-32219. PMID 10918061 DOI: 10.1074/Jbc.M005080200 |
0.424 |
|
| 2000 |
Martin-Soudant N, Drachman JG, Kaushansky K, Nepveu A. CDP/Cut DNA binding activity is down-modulated in granulocytes, macrophages and erythrocytes but remains elevated in differentiating megakaryocytes Leukemia. 14: 863-873. PMID 10803519 DOI: 10.1038/Sj.Leu.2401764 |
0.345 |
|
| 2000 |
Linden HM, Kaushansky K. The glycan domain of thrombopoietin enhances its secretion Biochemistry. 39: 3044-3051. PMID 10715125 DOI: 10.1021/Bi991756H |
0.323 |
|
| 2000 |
Sabath DF, Lin N, Sabath DE, Kaushansky K, Broudy VC. Tyrosine 462 of the membrane-proximal F'-G' loop of murine Mpl is not essential for high-affinity binding of thrombopoietin Cytokine. 12: 127-133. PMID 10671297 DOI: 10.1006/Cyto.1999.0531 |
0.33 |
|
| 2000 |
Hodohara K, Fujii N, Yamamoto N, Kaushansky K. Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU-MK) Blood. 95: 769-775. PMID 10648384 DOI: 10.1182/Blood.V95.3.769.003A49_769_775 |
0.433 |
|
| 1999 |
Rojnuckarin P, Drachman JG, Kaushansky K. Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis. Blood. 94: 1273-82. PMID 10438715 DOI: 10.1182/Blood.V94.4.1273.416K04_1273_1282 |
0.651 |
|
| 1999 |
Sabath DF, Kaushansky K, Broudy VC. Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding Blood. 94: 365-367. PMID 10381535 DOI: 10.1182/Blood.V94.1.365.413A46_365_367 |
0.348 |
|
| 1999 |
Kaushansky K. The enigmatic megakaryocyte gradually reveals its secrets Bioessays. 21: 353-360. PMID 10377897 DOI: 10.1002/(Sici)1521-1878(199904)21:4<353::Aid-Bies12>3.0.Co;2-P |
0.449 |
|
| 1999 |
Kaushansky K. Thrombopoietin and hematopoietic stem cell development Annals of the New York Academy of Sciences. 872: 314-319. PMID 10372133 DOI: 10.1111/J.1749-6632.1999.Tb08475.X |
0.412 |
|
| 1999 |
Drachman JG, Millett KM, Kaushansky K. Thrombopoietin signal transduction requires functional JAK2, not TYK2 Journal of Biological Chemistry. 274: 13480-13484. PMID 10224114 DOI: 10.1074/Jbc.274.19.13480 |
0.446 |
|
| 1999 |
Drachman JG, Rojnuckarin P, Kaushansky K. Thrombopoietin signal transduction: studies from cell lines and primary cells. Methods (San Diego, Calif.). 17: 238-49. PMID 10080909 DOI: 10.1006/Meth.1998.0734 |
0.633 |
|
| 1998 |
Camire RM, Pollak ES, Kaushansky K, Tracy PB. Secretable human platelet-derived factor V originates from the plasma pool Blood. 92: 3035-3041. PMID 9787136 DOI: 10.1182/Blood.V92.9.3035 |
0.328 |
|
| 1998 |
Jin L, Siritanaratkul N, Emery DW, Richard RE, Kaushansky K, Papayannopoulou T, Blau CA. Targeted expansion of genetically modified bone marrow cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 8093-7. PMID 9653145 DOI: 10.1073/Pnas.95.14.8093 |
0.36 |
|
| 1998 |
Broudy VC, Kaushansky K. Biology of thrombopoietin Current Opinion in Pediatrics. 10: 60-64. PMID 9529640 DOI: 10.1097/00008480-199802000-00012 |
0.324 |
|
| 1998 |
Hammond WP, Wun T, Kaplan A, Kaplan S, Paglieroni T, Kaushansky K, Foster DC. High concentrations of thrombopoietin activate platelets in vitro Clinical and Applied Thrombosis/Hemostasis. 4: 170-178. DOI: 10.1177/107602969800400306 |
0.344 |
|
| 1997 |
Kaushansky K, Torok-Storb B, Fibbe WE, Broxmeyer HE, Moore MAS, Hoffman R, Ihle JN. Thrombopoietin: More than a lineage-specific megakaryocyte growth factor Stem Cells. 15: 97-103. PMID 9368329 DOI: 10.1002/Stem.5530150813 |
0.429 |
|
| 1997 |
Broxmeyer HE, Mantel CR, Aronica SM, Kaushansky K, Griffin, Fibbe WE. Biology and mechanisms of action of synergistically stimulated myeloid progenitor cell proliferation and suppression by chemokines Stem Cells. 15: 69-78. PMID 9368327 DOI: 10.1002/Stem.5530150811 |
0.324 |
|
| 1997 |
Drachman JG, Kaushansky K. Dissecting the thrombopoietin receptor: Functional elements of the Mpl cytoplasmic domain Proceedings of the National Academy of Sciences of the United States of America. 94: 2350-2355. PMID 9122198 DOI: 10.1073/Pnas.94.6.2350 |
0.39 |
|
| 1997 |
Wun T, Paglieroni T, Hammond WP, Kaushansky K, Foster DC. Thrombopoietin is synergistic with other hematopoietic growth factors and physiologic platelet agonists for platelet activation in vitro American Journal of Hematology. 54: 225-232. PMID 9067502 DOI: 10.1002/(Sici)1096-8652(199703)54:3<225::Aid-Ajh9>3.0.Co;2-Y |
0.389 |
|
| 1997 |
Broudy VC, Lin NL, Sabath DF, Papayannopoulou T, Kaushansky K. Human platelets display high-affinity receptors for thrombopoietin Blood. 89: 1896-1904. PMID 9058709 DOI: 10.1182/Blood.V89.6.1896 |
0.355 |
|
| 1997 |
Kaushansky K. Thrombopoietin: Understanding and manipulating platelet production Annual Review of Medicine. 48: 1-11. PMID 9046940 DOI: 10.1146/Annurev.Med.48.1.1 |
0.397 |
|
| 1997 |
Drachman JG, Sabath DF, Fox NE, Kaushansky K. Thrombopoietin signal transduction in purified murine megakaryocytes Blood. 89: 483-492. PMID 9002950 DOI: 10.1182/Blood.V89.2.483 |
0.436 |
|
| 1997 |
Kaushansky K. Thrombopoietin: The primary regulator of platelet production Trends in Endocrinology and Metabolism. 8: 45-50. DOI: 10.1182/Blood.V86.2.419.Bloodjournal862419 |
0.376 |
|
| 1996 |
Kaushansky K, Broudy VC, Sitnicka E, Lofton-Day C, Grossmann A, Sprugel K. Do the preclinical effects of thrombopoietin correlate with its in vitro properties? Stem Cells. 14: 108-111. PMID 11012209 DOI: 10.1002/Stem.5530140713 |
0.414 |
|
| 1996 |
Broudy VC, Lin NL, Fox N, Taga T, Saito M, Kaushansky K. Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit Blood. 88: 2026-2032. PMID 8822921 DOI: 10.1182/Blood.V88.6.2026.Bloodjournal8862026 |
0.425 |
|
| 1996 |
Kaushansky K. The thrombocytopenia of cancer: Prospects for effective cytokine therapy Hematology/Oncology Clinics of North America. 10: 431-455. PMID 8707763 DOI: 10.1016/S0889-8588(05)70346-4 |
0.376 |
|
| 1996 |
Matous JV, Langley K, Kaushansky K. Structure-function relationships of stem cell factor: an analysis based on a series of human-murine stem cell factor chimera and the mapping of a neutralizing monoclonal antibody. Blood. 88: 437-44. PMID 8695790 DOI: 10.1182/Blood.V88.2.437.Bloodjournal882437 |
0.389 |
|
| 1996 |
Kaushansky K, O'Rork C, Shoemaker SG, McCarty J. The regulation of GM-CSF is dependent on a complex interplay of multiple nuclear proteins. Molecular Immunology. 33: 461-70. PMID 8676897 DOI: 10.1016/0161-5890(95)00156-5 |
0.32 |
|
| 1996 |
Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell. 85: 733-44. PMID 8646781 DOI: 10.1016/S0092-8674(00)81239-8 |
0.322 |
|
| 1996 |
Ku H, Yonemura Y, Kaushansky K, Ogawa M. Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice Blood. 87: 4544-4551. PMID 8639822 |
0.305 |
|
| 1996 |
Karsan A, Yee E, Kaushansky K, Harlan JM. Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells. Blood. 87: 3089-96. PMID 8605321 DOI: 10.1182/Blood.V87.8.3089.Bloodjournal8783089 |
0.337 |
|
| 1996 |
Sitnicka E, Lin N, Priestley GV, Fox N, Broudy VC, Wolf NS, Kaushansky K. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood. 87: 4998-5005. DOI: 10.1182/Blood.V87.12.4998.Bloodjournal87124998 |
0.447 |
|
| 1996 |
Kaushansky K. Megakaryocytes: Their precursors and their progeny Trends in Cardiovascular Medicine. 6: 261-265. DOI: 10.1016/S1050-1738(96)00108-9 |
0.379 |
|
| 1995 |
Kaushansky K. Physiology and preclinical studies of thrombopoietin Current Opinion in Hematology. 2: 172-176. PMID 9371991 DOI: 10.1097/00062752-199502030-00003 |
0.324 |
|
| 1995 |
Drachman JG, Kaushansky K. Structure and function of the cytokine receptor superfamily Current Opinion in Hematology. 2: 22-28. PMID 9371968 DOI: 10.1097/00062752-199502010-00004 |
0.355 |
|
| 1995 |
Kaushansky K. Thrombopoietin: The primary regulator of megakaryocyte and platelet production Thrombosis and Haemostasis. 74: 521-525. PMID 8578518 DOI: 10.1055/S-0038-1642732 |
0.45 |
|
| 1995 |
Monfardini C, Kieber-Emmons T, VonFeldt JM, O'Malley B, Rosenbaum H, Godillot AP, Kaushansky K, Brown CB, Voet D, McCallus DE. Recombinant antibodies in bioactive peptide design. The Journal of Biological Chemistry. 270: 6628-38. PMID 7896802 DOI: 10.1074/Jbc.270.12.6628 |
0.318 |
|
| 1995 |
Broudy VC, Kaushansky K. Thrombopoietin, the c-mpl ligand, is a major regulator of platelet production Journal of Leukocyte Biology. 57: 719-725. PMID 7759951 DOI: 10.1002/Jlb.57.5.719 |
0.403 |
|
| 1995 |
Kaushansky K. Thrombopoietin: Basic biology, clinical promise International Journal of Hematology. 62: 7-15. PMID 7670009 DOI: 10.1016/0925-5710(95)00379-7 |
0.407 |
|
| 1995 |
Kaushansky K, Broudy VC, Grossmann A, Humes J, Lin N, Hong Ping Ren, Bailey MC, Papayannopoulou T, Forstrom JW, Sprugel KH. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy Journal of Clinical Investigation. 96: 1683-1687. PMID 7657840 DOI: 10.1172/Jci118210 |
0.428 |
|
| 1995 |
McCarty JM, Sprugel KH, Fox NE, Sabath DE, Kaushansky K. Murine thrombopoietin mRNA levels are modulated by platelet count Blood. 86: 3668-3675. PMID 7579332 DOI: 10.1182/Blood.V86.10.3668.Bloodjournal86103668 |
0.31 |
|
| 1995 |
McCarty JM, Yee EK, Deisher TA, Harlan JM, Kaushansky K. Interleukin-4 induces endothelial vascular cell adhesion molecule-1 (VCAM-1) by an NF-kappa b-independent mechanism. Febs Letters. 372: 194-8. PMID 7556668 DOI: 10.1016/0014-5793(95)00976-G |
0.346 |
|
| 1995 |
Sattler M, Durstin MA, Frank DA, Okuda K, Kaushansky K, Salgia R, Griffin JD. The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases Experimental Hematology. 23: 1040-1048. PMID 7543416 |
0.316 |
|
| 1995 |
Kaushansky K, Broudy VC, Lin N, Jorgensen MJ, McCarty J, Fox N, Zucker-Franklin D, Lofton-Day C. Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development. Proceedings of the National Academy of Sciences of the United States of America. 92: 3234-8. PMID 7536928 DOI: 10.1073/Pnas.92.8.3234 |
0.38 |
|
| 1995 |
Broudy VC, Lin NL, Kaushansky K. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro Blood. 85: 1719-1726. PMID 7535585 DOI: 10.1182/Blood.V85.7.1719.Bloodjournal8571719 |
0.402 |
|
| 1995 |
Drachman JG, Griffin JD, Kaushansky K. The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl Journal of Biological Chemistry. 270: 4979-4982. PMID 7534285 DOI: 10.1074/Jbc.270.10.4979 |
0.415 |
|
| 1994 |
Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin Nature. 369: 568-571. PMID 8202159 DOI: 10.1038/369568A0 |
0.398 |
|
| 1994 |
Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo Nature. 369: 565-568. PMID 8202158 DOI: 10.1038/369565A0 |
0.393 |
|
| 1994 |
Kaushansky K. The mpl ligand: Molecular and cellular biology of the critical regulator of megakaryocyte development Stem Cells. 12: 91-96. PMID 7696972 |
0.386 |
|
| 1993 |
Deisher TA, Haddix TL, Montgomery KF, Pohlman TH, Kaushansky K, Harlan JM. The role of protein kinase C in the induction of VCAM-1 expression on human umbilical vein endothelial cells Febs Letters. 331: 285-290. PMID 7690717 DOI: 10.1016/0014-5793(93)80354-W |
0.35 |
|
| 1992 |
Kaushansky K, Lopez JA, Brown CB. Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells Biochemistry. 31: 1881-1886. PMID 1737041 DOI: 10.1021/Bi00121A042 |
0.372 |
|
| 1992 |
Kaushansky K, Shoemaker SG, Broudy VC, Lin NL, Matous JV, Alderman EM, Aghajanian JD, Szklut PJ, VanDyke RE, Pearce MK. Structure-function relationships of interleukin-3. An analysis based on the function and binding characteristics of a series of interspecies chimera of gibbon and murine interleukin-3. The Journal of Clinical Investigation. 90: 1879-88. PMID 1385477 DOI: 10.1172/Jci116065 |
0.364 |
|
| 1991 |
Kaushansky K, Brown CB, Petersdorf S. Hematopoietic colony-stimulating factors Biotechnology (Reading, Mass.). 19: 365-395. PMID 1723913 DOI: 10.1016/B978-0-7506-9120-8.50020-2 |
0.396 |
|
| 1990 |
Shoemaker SG, Hromas R, Kaushansky K. Transcriptional regulation of interleukin 3 gene expression in T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 87: 9650-4. PMID 2263617 DOI: 10.1073/Pnas.87.24.9650 |
0.393 |
|
| 1990 |
Bot F, Schipper P, Broeders L, Delwel R, Kaushansky K, Lowenberg B. Interleukin-1 alpha also induces granulocyte-macrophage colony- stimulating factor in immature normal bone marrow cells Blood. 76: 307-311. DOI: 10.1182/Blood.V76.2.307.Bloodjournal762307 |
0.386 |
|
| 1989 |
Kaushansky K, Miller JE, Morris DR, Wilson CB, Hammond WP. The role of lymphocytes and monocytes in hematopoietic growth factor production by peripheral blood mononuclear cells. Cellular Immunology. 122: 62-70. PMID 2787704 DOI: 10.1016/0008-8749(89)90148-2 |
0.349 |
|
| 1989 |
Kaushansky K, Shoemaker SG, Alfaro S, Brown C. Hematopoietic activity of granulocyte/macrophage colony-stimulating factor is dependent upon two distinct regions of the molecule: functional analysis based upon the activities of interspecies hybrid growth factors. Proceedings of the National Academy of Sciences of the United States of America. 86: 1213-7. PMID 2645577 DOI: 10.1073/Pnas.86.4.1213 |
0.344 |
|
| 1989 |
Delwel R, van Buitenen C, Salem M, Bot F, Gillis S, Kaushansky K, Altrock B, Lowenberg B. Interleukin-1 stimulates proliferation of acute myeloblastic leukemia cells by induction of granulocyte-macrophage colony-stimulating factor release Blood. 74: 586-593. DOI: 10.1182/Blood.V74.2.586.586 |
0.363 |
|
| 1988 |
Kaushansky K, Lin N, Adamson JW. Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation. The Journal of Clinical Investigation. 81: 92-7. PMID 2447127 DOI: 10.1172/Jci113316 |
0.339 |
|
| 1987 |
Kaushansky K, O'Hara PJ, Hart CE, Forstrom JW, Hagen FS. Role of carbohydrate in the function of human granulocyte-macrophage colony-stimulating factor. Biochemistry. 26: 4861-7. PMID 3499177 DOI: 10.1021/Bi00389A038 |
0.332 |
|
| 1986 |
Broudy VC, Kaushansky K, Segal GM, Harlan JM, Adamson JW. Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor. Proceedings of the National Academy of Sciences of the United States of America. 83: 7467-71. PMID 3489939 DOI: 10.1073/Pnas.83.19.7467 |
0.333 |
|
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