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Nicolas L. Fawzi, Ph.D. - Publications

Affiliations: 
Molecular Pharmacology, Physiology and Biotechnology Brown University, Providence, RI 
Area:
Neurodegenerative diseases, NMR
Website:
https://research.brown.edu/research/profile.php?id=1346961432
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Tang WS, Fawzi NL, Mittal J. Refining All-Atom Protein Force Fields for Polar-Rich, Prion-like, Low-Complexity Intrinsically Disordered Proteins. The Journal of Physical Chemistry. B. PMID 33078950 DOI: 10.1021/acs.jpcb.0c07545  0.307
2020 Ryan VH, Watters S, Amaya J, Khatiwada B, Venditti V, Naik MT, Fawzi NL. Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid-liquid phase separation and aggregation. Nucleic Acids Research. PMID 32870271 DOI: 10.1093/Nar/Gkaa710  0.332
2020 Fawzi NL. Elastin phase separation — structure or disorder? Nature Reviews Molecular Cell Biology. 21: 1-1. PMID 32860012 DOI: 10.1038/S41580-020-00291-0  0.33
2020 Conicella AE, Dignon GL, Zerze GH, Schmidt HB, D'Ordine AM, Kim YC, Rohatgi R, Ayala YM, Mittal J, Fawzi NL. TDP-43 α-helical structure tunes liquid-liquid phase separation and function. Proceedings of the National Academy of Sciences of the United States of America. PMID 32132204 DOI: 10.1073/Pnas.1912055117  0.37
2020 Murthy AC, Fawzi NL. The (un)structural biology of biomolecular liquid-liquid phase separation using NMR spectroscopy. The Journal of Biological Chemistry. PMID 31911439 DOI: 10.1074/Jbc.Rev119.009847  0.401
2020 Mathews KL, Marglous J, Fawzi NL. Structural and Biophysical Characterization of Splicing-Associated Assemblies of the SMN Protein Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1228  0.381
2019 Ryan VH, Fawzi NL. Physiological, Pathological, and Targetable Membraneless Organelles in Neurons. Trends in Neurosciences. PMID 31493925 DOI: 10.1016/J.Tins.2019.08.005  0.315
2019 Stackpole EE, Akins MR, Ivshina M, Murthy AC, Fawzi NL, Fallon JR. EGFP insertional mutagenesis reveals multiple FXR2P fibrillar states with differing ribosome association in neurons. Biology Open. 8. PMID 31434643 DOI: 10.1242/Bio.046383  0.315
2019 Murthy AC, Dignon GL, Kan Y, Zerze GH, Parekh SH, Mittal J, Fawzi NL. Molecular interactions underlying liquid-liquid phase separation of the FUS low-complexity domain. Nature Structural & Molecular Biology. 26: 637-648. PMID 31270472 DOI: 10.1038/S41594-019-0250-X  0.356
2019 Cable J, Brangwynne C, Seydoux G, Cowburn D, Pappu RV, Castañeda CA, Berchowitz LE, Chen Z, Jonikas M, Dernburg A, Mittag T, Fawzi NL. Phase separation in biology and disease-a symposium report. Annals of the New York Academy of Sciences. PMID 31199001 DOI: 10.1111/Nyas.14126  0.312
2018 Amaya J, Ryan VH, Fawzi NL. The SH3 domain of Fyn kinase interacts with and induces liquid-liquid phase separation of the low complexity domain of hnRNPA2. The Journal of Biological Chemistry. PMID 30397184 DOI: 10.1074/Jbc.Ra118.005120  0.317
2018 Yoshizawa T, Ali R, Jiou J, Fung HYJ, Burke KA, Kim SJ, Lin Y, Peeples WB, Saltzberg D, Soniat M, Baumhardt JM, Oldenbourg R, Sali A, Fawzi NL, Rosen MK, et al. Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell. 173: 693-705.e22. PMID 29677513 DOI: 10.1016/J.Cell.2018.03.003  0.314
2018 Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M. Protein Phase Separation: A New Phase in Cell Biology. Trends in Cell Biology. PMID 29602697 DOI: 10.1016/J.Tcb.2018.02.004  0.349
2018 Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM, Fawzi NL. A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. The Embo Journal. PMID 29438978 DOI: 10.15252/Embj.201797452  0.382
2018 Ryan VH, Dignon GL, Zerze GH, Chabata CV, Silva R, Conicella AE, Amaya J, Burke KA, Mittal J, Fawzi NL. Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation. Molecular Cell. PMID 29358076 DOI: 10.1016/J.Molcel.2017.12.022  0.343
2018 Venditti V, Fawzi NL. Probing the Atomic Structure of Transient Protein Contacts by Paramagnetic Relaxation Enhancement Solution NMR. Methods in Molecular Biology (Clifton, N.J.). 1688: 243-255. PMID 29151213 DOI: 10.1007/978-1-4939-7386-6_12  0.399
2017 Janke AM, Seo DH, Rahmanian V, Conicella AE, Mathews KL, Burke KA, Mittal J, Fawzi NL. Lysines in RNA polymerase II C-terminal domain contribute to TAF15 fibril recruitment. Biochemistry. PMID 28945358 DOI: 10.1021/Acs.Biochem.7B00310  0.313
2017 Monahan Z, Ryan VH, Janke AM, Burke KA, Rhoads SN, Zerze GH, O'Meally R, Dignon GL, Conicella AE, Zheng W, Best RB, Cole RN, Mittal J, Shewmaker F, Fawzi NL. Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity. The Embo Journal. PMID 28790177 DOI: 10.15252/Embj.201696394  0.383
2017 Fawzi N. Visualizing Structural Details of Disordered Domain Phase Separation Associated with ALS and Cancers Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.046  0.334
2016 Conicella AE, Zerze GH, Mittal J, Fawzi NL. ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain. Structure (London, England : 1993). PMID 27545621 DOI: 10.1016/J.Str.2016.07.007  0.372
2015 Burke KA, Janke AM, Rhine CL, Fawzi NL. Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II. Molecular Cell. PMID 26455390 DOI: 10.1016/J.Molcel.2015.09.006  0.405
2014 Fawzi NL, Libich DS, Ying J, Tugarinov V, Clore GM. Characterizing methyl-bearing side chain contacts and dynamics mediating amyloid β protofibril interactions using ¹³C(methyl)-DEST and lifetime line broadening. Angewandte Chemie (International Ed. in English). 53: 10345-9. PMID 25130489 DOI: 10.1002/Anie.201405180  0.375
2014 Conicella AE, Fawzi NL. The C-terminal threonine of Aβ43 nucleates toxic aggregation via structural and dynamical changes in monomers and protofibrils. Biochemistry. 53: 3095-105. PMID 24773532 DOI: 10.1021/Bi500131A  0.45
2013 Libich DS, Fawzi NL, Ying J, Clore GM. Probing the transient dark state of substrate binding to GroEL by relaxation-based solution NMR. Proceedings of the National Academy of Sciences of the United States of America. 110: 11361-6. PMID 23798407 DOI: 10.1073/Pnas.1305715110  0.411
2012 Fawzi NL, Ying J, Torchia DA, Clore GM. Probing exchange kinetics and atomic resolution dynamics in high-molecular-weight complexes using dark-state exchange saturation transfer NMR spectroscopy. Nature Protocols. 7: 1523-33. PMID 22814391 DOI: 10.1038/Nprot.2012.077  0.357
2012 Cellmer T, Fawzi NL. Coarse-grained simulations of protein aggregation. Methods in Molecular Biology (Clifton, N.J.). 899: 453-70. PMID 22735969 DOI: 10.1007/978-1-61779-921-1_27  0.402
2012 Venditti V, Fawzi NL, Clore GM. An efficient protocol for incorporation of an unnatural amino acid in perdeuterated recombinant proteins using glucose-based media. Journal of Biomolecular Nmr. 52: 191-5. PMID 22350951 DOI: 10.1007/S10858-012-9606-9  0.308
2012 Ball KA, Phillips AH, Fawzi NL, Wemmer DE, Head-Gordon T. Amyloid-Beta Heterogeneous Conformational Ensembles: Differences Between the 40- and 42-Residue Peptides and Implications for Dimer Polyamorphism Biophysical Journal. 102: 631a. DOI: 10.1016/J.Bpj.2011.11.3437  0.664
2011 Fawzi NL, Ying J, Ghirlando R, Torchia DA, Clore GM. Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR. Nature. 480: 268-72. PMID 22037310 DOI: 10.1038/Nature10577  0.424
2011 Venditti V, Fawzi NL, Clore GM. Automated sequence- and stereo-specific assignment of methyl-labeled proteins by paramagnetic relaxation and methyl-methyl nuclear Overhauser enhancement spectroscopy. Journal of Biomolecular Nmr. 51: 319-28. PMID 21935714 DOI: 10.1007/S10858-011-9559-4  0.306
2011 Ball KA, Phillips AH, Nerenberg PS, Fawzi NL, Wemmer DE, Head-Gordon T. Homogeneous and heterogeneous tertiary structure ensembles of amyloid-β peptides. Biochemistry. 50: 7612-28. PMID 21797254 DOI: 10.1021/Bi200732X  0.771
2011 Fawzi NL, Phillips AH, Ruscio JZ, Doucleff M, Wemmer DE, Head-Gordon T. Structure and dynamics of the Aβ 21-30 peptide from the interplay of NMR experiments and molecular simulations (Journal of the American Chemical Society (2008) 130 (6145-6158) DOI: 10.1021/ja710366c) Journal of the American Chemical Society. 133: 11816. DOI: 10.1021/ja204315n  0.729
2010 Fawzi NL, Ying J, Torchia DA, Clore GM. Kinetics of amyloid beta monomer-to-oligomer exchange by NMR relaxation. Journal of the American Chemical Society. 132: 9948-51. PMID 20604554 DOI: 10.1021/Ja1048253  0.429
2010 Fawzi NL, Doucleff M, Suh JY, Clore GM. Mechanistic details of a protein-protein association pathway revealed by paramagnetic relaxation enhancement titration measurements. Proceedings of the National Academy of Sciences of the United States of America. 107: 1379-84. PMID 20080627 DOI: 10.1073/Pnas.0909370107  0.352
2010 Ruscio JZ, Fawzi NL, Head-Gordon T. How hot? Systematic convergence of the replica exchange method using multiple reservoirs. Journal of Computational Chemistry. 31: 620-7. PMID 19554556 DOI: 10.1002/Jcc.21355  0.694
2008 Fawzi NL, Yap EH, Okabe Y, Kohlstedt KL, Brown SP, Head-Gordon T. Contrasting disease and nondisease protein aggregation by molecular simulation. Accounts of Chemical Research. 41: 1037-47. PMID 18646868 DOI: 10.1021/Ar800062K  0.749
2008 Fawzi NL, Phillips AH, Ruscio JZ, Doucleff M, Wemmer DE, Head-Gordon T. Structure and dynamics of the Abeta(21-30) peptide from the interplay of NMR experiments and molecular simulations. Journal of the American Chemical Society. 130: 6145-58. PMID 18412346 DOI: 10.1021/Ja710366C  0.748
2008 Fawzi NL, Kohlstedt KL, Okabe Y, Head-Gordon T. Protofibril assemblies of the arctic, Dutch, and Flemish mutants of the Alzheimer's Abeta1-40 peptide. Biophysical Journal. 94: 2007-16. PMID 18032553 DOI: 10.1529/Biophysj.107.121467  0.612
2008 Yap EH, Fawzi NL, Head-Gordon T. A coarse-grained alpha-carbon protein model with anisotropic hydrogen-bonding. Proteins. 70: 626-38. PMID 17879350 DOI: 10.1002/Prot.21515  0.675
2007 Lin MS, Fawzi NL, Head-Gordon T. Hydrophobic potential of mean force as a solvation function for protein structure prediction. Structure (London, England : 1993). 15: 727-40. PMID 17562319 DOI: 10.1016/J.Str.2007.05.004  0.673
2007 Fawzi NL, Okabe Y, Yap EH, Head-Gordon T. Determining the critical nucleus and mechanism of fibril elongation of the Alzheimer's Abeta(1-40) peptide. Journal of Molecular Biology. 365: 535-50. PMID 17070840 DOI: 10.1016/J.Jmb.2006.10.011  0.703
2005 Marianayagam NJ, Fawzi NL, Head-Gordon T. Protein folding by distributed computing and the denatured state ensemble. Proceedings of the National Academy of Sciences of the United States of America. 102: 16684-9. PMID 16267133 DOI: 10.1073/Pnas.0506388102  0.588
2005 Fawzi NL, Chubukov V, Clark LA, Brown S, Head-Gordon T. Influence of denatured and intermediate states of folding on protein aggregation. Protein Science : a Publication of the Protein Society. 14: 993-1003. PMID 15772307 DOI: 10.1110/Ps.041177505  0.675
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