Steven C. Leiser, Ph.D. - Related publications

Synaptic Transmission Lundbeck Research USA 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Hamati R, El Mansari M, Blier P. Serotonin-2B receptor antagonism increases the activity of dopamine and glutamate neurons in the presence of selective serotonin reuptake inhibition. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32473594 DOI: 10.1038/s41386-020-0723-y   
2020 Fukumoto K, Fogaça MV, Liu RJ, Duman CH, Li XY, Chaki S, Duman RS. Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT receptor stimulation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32396921 DOI: 10.1038/s41386-020-0705-0   
2020 Azimi Z, Barzan R, Spoida K, Surdin T, Wollenweber P, Mark MD, Herlitze S, Jancke D. Separable gain control of ongoing and evoked activity in the visual cortex by serotonergic input. Elife. 9. PMID 32252889 DOI: 10.7554/eLife.53552   
2020 Li X, Sun X, Sun J, Zu Y, Zhao S, Sun X, Li L, Zhang X, Wang W, Liang Y, Wang W, Liang X, Sun C, Guan X, Tang M. Depressive-like State Sensitizes 5-HT and 5-HT Auto-receptors in the Dorsal Raphe Nucleus Sub-system. Behavioural Brain Research. 112618. PMID 32360167 DOI: 10.1016/j.bbr.2020.112618   
2020 Baptista-de-Souza D, Tavares LRR, Furuya-da-Cunha EM, Carneiro de Oliveira PE, Canto-de-Souza L, Nunes-de-Souza RL, Canto-de-Souza A. Chronic Fluoxetine Impairs the Effects of 5-HT and 5-HT Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in Mice. Frontiers in Pharmacology. 11: 260. PMID 32218734 DOI: 10.3389/fphar.2020.00260   
2020 Xue Y, Wei SQ, Wang PX, Wang WY, Liu EQ, Traub RJ, Cao DY. Down-regulation of spinal 5-HT and 5-HT receptors contributes to somatic hyperalgesia induced by orofacial inflammation combined with stress. Neuroscience. PMID 32497757 DOI: 10.1016/j.neuroscience.2020.05.044   
2020 Lacivita E, Niso M, Stama ML, Arzuaga A, Altamura C, Costa L, Desaphy JF, Ragozzino ME, Ciranna L, Leopoldo M. Privileged scaffold-based design to identify a novel drug-like 5-HT receptor-preferring agonist to target Fragile X syndrome. European Journal of Medicinal Chemistry. 199: 112395. PMID 32442850 DOI: 10.1016/j.ejmech.2020.112395   
2020 Tiger M, Veldman ER, Ekman CJ, Halldin C, Svenningsson P, Lundberg J. A randomized placebo-controlled PET study of ketamine´s effect on serotonin receptor binding in patients with SSRI-resistant depression. Translational Psychiatry. 10: 159. PMID 32475989 DOI: 10.1038/s41398-020-0844-4   
2020 De Deurwaerdère P, Di Giovanni G. Serotonin in Health and Disease. International Journal of Molecular Sciences. 21. PMID 32429111 DOI: 10.3390/ijms21103500   
2020 Jones LA, Sun EW, Martin AM, Keating DJ. The ever-changing roles of serotonin. The International Journal of Biochemistry & Cell Biology. 105776. PMID 32479926 DOI: 10.1016/j.biocel.2020.105776   
2020 Comai S, De Gregorio D, Posa L, Ochoa-Sanchez R, Bedini A, Gobbi G. Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking MT receptors. Journal of Pineal Research. e12653. PMID 32239546 DOI: 10.1111/jpi.12653   
2020 Narayanaswami V, Tong J, Fiorino F, Severino B, Sparaco R, Magli E, Giordano F, Bloomfield PM, Prabhakaran J, Mann JJ, Vasdev N, Dahl K, Kumar JSD. Synthesis, in vitro and in vivo evaluation of C-O-methylated arylpiperazines as potential serotonin 1A (5-HT) receptor antagonist radiotracers. Ejnmmi Radiopharmacy and Chemistry. 5: 13. PMID 32430632 DOI: 10.1186/s41181-020-00096-8   
2020 Cimadevila M, Gómez-García L, Martínez AL, Iglesias A, López-Giménez J, Castro M, Cadavid MI, Loza MI, Brea J. Essential role of the C148 - C227 disulphide bridge in the human 5-HT homodimeric receptor. Biochemical Pharmacology. 113985. PMID 32311347 DOI: 10.1016/j.bcp.2020.113985   
2020 Phan DH, Shin EJ, Sharma N, Hoang Yen TP, Dang DK, Lee YS, Lee YJ, Nah SY, Cheong JH, Jeong JH, Kim HC. 5-HT receptor-mediated PKCδ phosphorylation is critical for serotonergic impairments induced by p-chloroamphetamine in mice. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 111395. PMID 32437895 DOI: 10.1016/j.fct.2020.111395   
2020 Miyagishi H, Tsuji M, Miyagawa K, Kurokawa K, Mochida-Saito A, Takahashi K, Ishige K, Takeda H. Characterization of 5-HT receptor and transport protein KIF13A expression in the hippocampus of stress-adaptive and -maladaptive mice. Neuroscience Letters. 135082. PMID 32461107 DOI: 10.1016/j.neulet.2020.135082   
2020 Flaive A, Cabelguen JM, Ryczko D. The serotonin reuptake blocker citalopram destabilizes fictive locomotor activity in salamander axial circuits through 5-HT1A receptors. Journal of Neurophysiology. PMID 32401145 DOI: 10.1152/jn.00179.2020   
2020 Majczyński H, Cabaj AM, Jordan LM, Sławińska U. Contribution of 5-HT Receptors to the Control of the Spinal Locomotor System in Intact Rats. Frontiers in Neural Circuits. 14: 14. PMID 32425760 DOI: 10.3389/fncir.2020.00014   
2020 Esquivel-Franco DC, de Boer SF, Waldinger M, Olivier B, Olivier JDA. Pharmacological Studies on the Role of 5-HT Receptors in Male Sexual Behavior of Wildtype and Serotonin Transporter Knockout Rats. Frontiers in Behavioral Neuroscience. 14: 40. PMID 32296313 DOI: 10.3389/fnbeh.2020.00040   
2020 Nieto C, Rayo I, de Las Casas-Engel M, Izquierdo E, Alonso B, Béchade C, Maroteaux L, Vega MA, Corbí ÁL. Serotonin (5-HT) Shapes the Macrophage Gene Profile through the 5-HT-Dependent Activation of the Aryl Hydrocarbon Receptor. Journal of Immunology (Baltimore, Md. : 1950). PMID 32253244 DOI: 10.4049/jimmunol.1901531   
2020 Martin AM, Jones LA, Jessup CF, Sun EW, Keating DJ. Diet differentially regulates enterochromaffin cell serotonin content, density and nutrient sensitivity in the mouse small and large intestine. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. e13869. PMID 32378785 DOI: 10.1111/nmo.13869   
2020 Chiang MD, Frey K, Lee C, Kharasch ED, Tallchief D, Sawyer C, Blood J, Back HM, Kagan L, Haroutounian S. Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans. British Journal of Clinical Pharmacology. PMID 32495990 DOI: 10.1111/bcp.14412   
2020 Murphy SE, de Cates AN, Gillespie AL, Godlewska BR, Scaife JC, Wright LC, Cowen PJ, Harmer CJ. Translating the promise of 5HT receptor agonists for the treatment of depression. Psychological Medicine. 1-10. PMID 32241310 DOI: 10.1017/S0033291720000604   
2020 Wang L, Fan X, Han J, Cai M, Wang X, Wang Y, Shang J. Gut-Derived Serotonin Contributes to the Progression of Non-Alcoholic Steatohepatitis the Liver HTR2A/PPARγ2 Pathway. Frontiers in Pharmacology. 11: 553. PMID 32477107 DOI: 10.3389/fphar.2020.00553   
2020 Martin V, Mathieu L, Diaz J, Salman H, Alterio J, Chevarin C, Lanfumey L, Hamon M, Austin MC, Darmon M, Stockmeier CA, Masson J. Key role of the 5-HT1A receptor addressing protein Yif1B in serotonin neurotransmission and SSRI treatment. Journal of Psychiatry & Neuroscience : Jpn. 45: 190134. PMID 32459080 DOI: 10.1503/jpn.190134   
2020 Sandoval-Sánchez AR, Cedillo Zavaleta LN, Jiménez JC, Ruíz-García I, Miranda F. Administration of low doses of the 5-HT receptor agonist 8-OH-DPAT attenuates the discriminative signal of amphetamine in the conditioned taste aversion procedure. Pharmacology, Biochemistry, and Behavior. 172932. PMID 32315693 DOI: 10.1016/j.pbb.2020.172932   
2020 Cui X, Zhao X, Wang Y, Yang Y, Zhang H. Glucagon‑like peptide‑1 analogue exendin‑4 modulates serotonin transporter expression in intestinal epithelial cells. Molecular Medicine Reports. PMID 32319618 DOI: 10.3892/mmr.2020.10976   
2020 Ostrowska K, Leśniak A, Karczyńska U, Jeleniewicz P, Głuch-Lutwin M, Mordyl B, Siwek A, Trzaskowski B, Sacharczuk M, Bujalska-Zadrożny M. 6-Acetyl-5-hydroxy-4,7-dimethylcoumarin derivatives: Design, synthesis, modeling studies, 5-HT, 5-HT and D receptors affinity. Bioorganic Chemistry. 100: 103912. PMID 32388437 DOI: 10.1016/j.bioorg.2020.103912   
2020 Liu Q, Yao X, Gao S, Li R, Li B, Yang W, Cui R. Role of 5-HT receptors in neuropathic pain: potential therapeutic implications. Pharmacological Research. 104949. PMID 32464329 DOI: 10.1016/j.phrs.2020.104949   
2020 Xia Y, Xia L, Jin Z, Jin R, Paudel O, Sham JSK. Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension. Analytical Cellular Pathology (Amsterdam). 2020: 8927381. PMID 32399392 DOI: 10.1155/2020/8927381   
2020 Chang KW, Zong HF, Wang M, Rizvi MY, Neha SI, Yang WN, Ji SF, Ma YB, Qian YH. PNU282987 alleviates Aβ-induced anxiety and depressive-like behaviors through upregulation of α7nAChR by ERK-serotonin receptors pathway. Neuroscience Letters. 135118. PMID 32502508 DOI: 10.1016/j.neulet.2020.135118   
2020 Hatini PG, Commons KG. A 5-HT -Receptor Agonist Protects Dravet Syndrome Mice from Seizure and Early Death. The European Journal of Neuroscience. PMID 32394465 DOI: 10.1111/ejn.14776   
2020 Pearlman EM, Wilbraham D, Dennehy EB, Berg PH, Tsai M, Doty EG, Kay GG. Effects of lasmiditan on simulated driving performance: Results of two randomized, blinded, crossover studies with placebo and active controls. Human Psychopharmacology. e2732. PMID 32449213 DOI: 10.1002/hup.2732   
2020 Papaseit E, Olesti E, Pérez-Mañá C, Torrens M, Grifell M, Ventura M, Pozo OJ, de Sousa Fernandes Perna EB, Ramaekers JG, de la Torre R, Farré M. Acute Effects of 2C-E in Humans: An Observational Study. Frontiers in Pharmacology. 11: 233. PMID 32256350 DOI: 10.3389/fphar.2020.00233   
2020 Milanetto AC, Fassan M, David A, Pasquali C. Serotonin-Secreting Neuroendocrine Tumours of the Pancreas. Journal of Clinical Medicine. 9. PMID 32384679 DOI: 10.3390/jcm9051363   
2020 Sharma R. Data science-driven analyses of drugs inducing hypertension as an adverse effect. Molecular Diversity. PMID 32415493 DOI: 10.1007/s11030-020-10059-5   
2020 Bertrand D, Wallace TL. A Review of the Cholinergic System and Therapeutic Approaches to Treat Brain Disorders. Current Topics in Behavioral Neurosciences. PMID 32451956 DOI: 10.1007/7854_2020_141   
2020 Jensen AA, Halberstadt AL, Märcher-Rørsted E, Odland AU, Chatha M, Speth N, Liebscher G, Hansen M, Bräuner-Osborne H, Palner M, Andreasen JT, Kristensen JL. The selective 5-HT receptor agonist 25CN-NBOH: Structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [H]25CN-NBOH. Biochemical Pharmacology. 177: 113979. PMID 32298690 DOI: 10.1016/j.bcp.2020.113979   
2020 Burnat G, Brański P, Solich J, Kolasa M, Chruścicka B, Dziedzicka-Wasylewska M, Pilc A. The functional cooperation of 5-HT and mGlu4R in HEK-293 cell line. Pharmacological Reports : Pr. PMID 32472388 DOI: 10.1007/s43440-020-00114-1   
2020 Koblan KS, Kent J, Hopkins SC, Krystal JH, Cheng H, Goldman R, Loebel A. A Non-D2-Receptor-Binding Drug for the Treatment of Schizophrenia. The New England Journal of Medicine. 382: 1497-1506. PMID 32294346 DOI: 10.1056/NEJMoa1911772   
2020 Baldassarri SR, Park E, Finnema SJ, Planeta B, Nabulsi N, Najafzadeh S, Ropchan J, Huang Y, Hannestad J, Maloney K, Bhagwagar Z, Carson RE. Inverse changes in raphe and cortical 5-HT receptor availability after acute tryptophan depletion in healthy human subjects. Synapse (New York, N.Y.). PMID 32324935 DOI: 10.1002/syn.22159   
2020 Cortes-Altamirano JL, Reyes-Long S, Bonilla-Jaime H, Clavijo-Cornejo D, Vargas J, Bandala C, Alfaro-Rodriguez A. Acute administration of levetiracetam in tonic pain model modulates gene expression of 5HT and 5HT receptors in the thalamus of rats (Rattus norvergicus). Molecular Biology Reports. PMID 32285329 DOI: 10.1007/s11033-020-05419-1   
2020 Philogene M, Massie AB, Kong H, Shah P, Cochrane A, Ponor I, Levine D, Shah KB, Hsu S, Feller ED, Rodrigo ME, Najjar SS, Tunc I, Berry G, Marboe C, et al. Association between Pretransplant Antibody against Angiotensin II Type 1 Receptor and Posttransplant Allograft Injury. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 39: S30. PMID 32465339 DOI: 10.1016/j.healun.2020.01.1175   
2020 Yano H, Adhikari P, Naing S, Hoffman AF, Baumann MH, Lupica CR, Shi L. Positive allosteric modulation of the 5-HT receptor by indole-based synthetic cannabinoids abused by humans. Acs Chemical Neuroscience. PMID 32324370 DOI: 10.1021/acschemneuro.0c00034   
2020 Timothy M, Forlano PM. Serotonin distribution in the brain of the plainfin midshipman: substrates for vocal-acoustic modulation and a reevaluation of the serotonergic system in teleost fishes. The Journal of Comparative Neurology. PMID 32361985 DOI: 10.1002/cne.24938   
2020 Courault P, Emery S, Bouvard S, Liger F, Chauveau F, Meyronet D, Fourier A, Billard T, Zimmer L, Lancelot S. Change in Expression of 5-HT6 Receptor at Different Stages of Alzheimer's Disease: A Postmortem Study with the PET Radiopharmaceutical [18F]2FNQ1P. Journal of Alzheimer's Disease : Jad. PMID 32417774 DOI: 10.3233/JAD-191278   
2020 Zhou X, Atsuta I, Ayukawa Y, Narimatsu I, Zhou T, Hu J, Koyano K. Effects of Different Divalent Cation Hydrothermal Treatments of Titanium Implant Surfaces for Epithelial Tissue Sealing. Materials (Basel, Switzerland). 13. PMID 32349433 DOI: 10.3390/ma13092038   
2020 Giri R, Alberts I, Harding WW. Synthesis, pharmacological evaluations, and molecular docking studies on a new 1,3,4,11b-tetrahydro-1H-fluoreno[9,1-cd]azepine framework: Rigidification of D receptor selective 1-phenylbenzazepines and discovery of a new 5-HT receptor scaffold. Chemical Biology & Drug Design. PMID 32279445 DOI: 10.1111/cbdd.13691   
2020 Tan O, Martin LJ, Bowen MT. Divergent pathways mediate 5-HT receptor agonist effects on close social interaction, grooming and aggressive behaviour in mice: Exploring the involvement of the oxytocin and vasopressin systems. Journal of Psychopharmacology (Oxford, England). 269881120913150. PMID 32312154 DOI: 10.1177/0269881120913150   
2020 Andrade JBC, Mohr JP, Lima FO, de Carvalho JJF, Barros LCM, Nepomuceno CR, Ferrer JVCC, Silva GS. The role of hemorrhagic transformation in acute ischemic stroke upon clinical complications and outcomes. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. 104898. PMID 32417239 DOI: 10.1016/j.jstrokecerebrovasdis.2020.104898   
2020 Mazza M, Marano G, Traversi G, Sani G, Janiri L. Evidence On The New Drug Lumateperone (Iti-007) For Psychiatric And Neurological Disorders. Cns & Neurological Disorders Drug Targets. PMID 32479249 DOI: 10.2174/1871527319666200601145653