Joaquin Espinosa - Publications

Affiliations: 
Molecular, Cellular and Developmental Biology University of Colorado, Boulder, Boulder, CO, United States 
Area:
Human Development, Molecular Biology, Neuroscience Biology

57/129 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Cozzolino K, Sanford L, Hunter S, Molison K, Erickson B, Jones T, Ajit D, Galbraith MD, Espinosa JM, Bentley DL, Allen MA, Dowell RD, Taatjes DJ. Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome. Biorxiv : the Preprint Server For Biology. PMID 37461585 DOI: 10.1101/2023.07.05.547813  0.338
2023 Ludwig MP, Galbraith MD, Eduthan NP, Hill AA, Clay MR, Moreno Tellez C, Wilky BA, Elias A, Espinosa JM, Sullivan KD. Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway. Cancer Research. PMID 37205634 DOI: 10.1158/0008-5472.CAN-22-3173  0.316
2023 Szwarc MM, Guarnieri AL, Joshi M, Duc HN, Laird MC, Pandey A, Khanal S, Dohm E, Bui AK, Sullivan KD, Galbraith MD, Andrysik Z, Espinosa JM. FAM193A is a positive regulator of p53 activity. Cell Reports. 42: 112230. PMID 36897777 DOI: 10.1016/j.celrep.2023.112230  0.509
2023 Tatavosian R, Donovan MG, Galbraith MD, Duc HN, Szwarc MM, Joshi MU, Frieman A, Bilousova G, Cao Y, Smith KP, Song K, Rachubinski AL, Andrysik Z, Espinosa JM. Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation. Cell Death and Differentiation. PMID 36681780 DOI: 10.1038/s41418-023-01113-4  0.579
2022 Donovan MG, Galbraith MD, Espinosa JM. Multi-omics investigation reveals functional specialization of transcriptional cyclin dependent kinases in cancer biology. Scientific Reports. 12: 22505. PMID 36577800 DOI: 10.1038/s41598-022-26860-1  0.395
2022 Andrysik Z, Sullivan KD, Kieft JS, Espinosa JM. PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response. Nature Communications. 13: 7400. PMID 36456590 DOI: 10.1038/s41467-022-35089-5  0.484
2021 Galbraith MD, Andrysik Z, Sullivan KD, Espinosa JM. Global Analyses to Identify Direct Transcriptional Targets of p53. Methods in Molecular Biology (Clifton, N.J.). 2267: 19-56. PMID 33786783 DOI: 10.1007/978-1-0716-1217-0_3  0.598
2021 Andrysik Z, Bender H, Galbraith MD, Espinosa JM. Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response. Nature Communications. 12: 1375. PMID 33654095 DOI: 10.1038/s41467-021-21687-2  0.364
2020 Rizzotto D, Zaccara S, Rossi A, Galbraith MD, Andrysik Z, Pandey A, Sullivan KD, Quattrone A, Espinosa JM, Dassi E, Inga A. Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30. Cell Reports. 30: 4355-4369.e6. PMID 32234473 DOI: 10.1016/J.Celrep.2020.03.011  0.417
2019 Steinparzer I, Sedlyarov V, Rubin JD, Eislmayr K, Galbraith MD, Levandowski CB, Vcelkova T, Sneezum L, Wascher F, Amman F, Kleinova R, Bender H, Andrysik Z, Espinosa JM, Superti-Furga G, et al. Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. Molecular Cell. PMID 31495563 DOI: 10.1016/J.Molcel.2019.07.034  0.454
2019 Espinosa JM. Transcriptional CDKs in the spotlight. Transcription. 10: 45-46. PMID 30946639 DOI: 10.1080/21541264.2019.1597479  0.509
2018 Sullivan KD, Galbraith MD, Andrysik Z, Espinosa JM. Mechanisms of transcriptional regulation by p53. Cell Death and Differentiation. 25: 133-143. PMID 31745311 DOI: 10.1038/cdd.2017.174  0.599
2018 Galbraith MD, Bender H, Espinosa JM. Therapeutic targeting of transcriptional cyclin-dependent kinases. Transcription. 1-19. PMID 30409083 DOI: 10.1080/21541264.2018.1539615  0.426
2018 Fitzwalter BE, Towers CG, Sullivan KD, Andrysik Z, Hoh M, Ludwig M, O'Prey J, Ryan KM, Espinosa JM, Morgan MJ, Thorburn A. Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover. Developmental Cell. 44: 555-565.e3. PMID 29533771 DOI: 10.1016/J.Devcel.2018.02.014  0.301
2017 Sullivan KD, Galbraith MD, Andrysik Z, Espinosa JM. Mechanisms of transcriptional regulation by p53. Cell Death and Differentiation. PMID 29125602 DOI: 10.1038/Cdd.2017.174  0.604
2017 Andrysik Z, Galbraith MD, Guarnieri AL, Zaccara S, Sullivan KD, Pandey A, MacBeth M, Inga A, Espinosa JM. Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity. Genome Research. PMID 28904012 DOI: 10.1101/Gr.220533.117  0.415
2017 Audetat KA, Galbraith MD, Odell AT, Lee T, Pandey A, Espinosa JM, Dowell RD, Taatjes DJ. A kinase-independent role for CDK19 in p53 response. Molecular and Cellular Biology. PMID 28416637 DOI: 10.1128/Mcb.00626-16  0.609
2016 Sullivan KD, Lewis HC, Hill AA, Pandey A, Jackson LP, Cabral JM, Smith KP, Liggett LA, Gomez EB, Galbraith MD, DeGregori J, Espinosa JM. Trisomy 21 consistently activates the interferon response. Elife. 5. PMID 27472900 DOI: 10.7554/Elife.16220  0.357
2016 Perez-Perri JI, Dengler VL, Audetat KA, Pandey A, Bonner EA, Urh M, Mendez J, Daniels DL, Wappner P, Galbraith MD, Espinosa JM. The TIP60 Complex Is a Conserved Coactivator of HIF1A. Cell Reports. PMID 27320910 DOI: 10.1016/j.celrep.2016.05.082  0.516
2015 Towers CG, Guarnieri AL, Micalizzi DS, Harrell JC, Gillen AE, Kim J, Wang CA, Oliphant MU, Drasin DJ, Guney MA, Kabos P, Sartorius CA, Tan AC, Perou CM, Espinosa JM, et al. The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. Nature Communications. 6: 10077. PMID 26687066 DOI: 10.1038/Ncomms10077  0.39
2015 Abraham CG, Espinosa JM. The Crusade against Mutant p53: Does the COMPASS Point to the Holy Grail? Cancer Cell. 28: 407-8. PMID 26461087 DOI: 10.1016/j.ccell.2015.09.019  0.424
2015 Espinosa JM, Sullivan KD. A signature for success. Elife. 4. PMID 26079875 DOI: 10.7554/Elife.08773  0.344
2015 Tentler JJ, Ionkina AA, Tan AC, Newton TP, Pitts TM, Glogowska MJ, Kabos P, Sartorius CA, Sullivan KD, Espinosa JM, Eckhardt SG, Diamond JR. p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer. Molecular Cancer Therapeutics. 14: 1117-29. PMID 25758253 DOI: 10.1158/1535-7163.Mct-14-0538-T  0.433
2015 Sullivan KD, Palaniappan VV, Espinosa JM. ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels. Cell Cycle (Georgetown, Tex.). 14: 56-63. PMID 25483068 DOI: 10.4161/15384101.2014.973330  0.494
2014 Allen MA, Andrysik Z, Dengler VL, Mellert HS, Guarnieri A, Freeman JA, Sullivan KD, Galbraith MD, Luo X, Kraus WL, Dowell RD, Espinosa JM. Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms. Elife. 3: e02200. PMID 24867637 DOI: 10.7554/Elife.02200  0.641
2014 Guarnieri AL, Espinosa JM. Back to bases: how a nucleotide biosynthetic enzyme controls p53 activation. Molecular Cell. 53: 365-7. PMID 24507714 DOI: 10.1016/j.molcel.2014.01.025  0.307
2014 Dengler VL, Galbraith MD, Espinosa JM. Transcriptional regulation by hypoxia inducible factors. Critical Reviews in Biochemistry and Molecular Biology. 49: 1-15. PMID 24099156 DOI: 10.3109/10409238.2013.838205  0.423
2013 Galbraith MD, Saxton J, Li L, Shelton SJ, Zhang H, Espinosa JM, Shaw PE. ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1. Nucleic Acids Research. 41: 10241-53. PMID 24049075 DOI: 10.1093/nar/gkt837  0.493
2013 Galbraith MD, Allen MA, Bensard CL, Wang X, Schwinn MK, Qin B, Long HW, Daniels DL, Hahn WC, Dowell RD, Espinosa JM. HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell. 153: 1327-39. PMID 23746844 DOI: 10.1016/J.Cell.2013.04.048  0.525
2013 Andrysik Z, Kim J, Tan AC, Espinosa JM. A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation. Cell Reports. 3: 1346-54. PMID 23684607 DOI: 10.1016/j.celrep.2013.04.014  0.561
2013 Gallant-Behm CL, Espinosa JM. ΔNp63α utilizes multiple mechanisms to repress transcription in squamous cell carcinoma cells. Cell Cycle (Georgetown, Tex.). 12: 409-16. PMID 23324337 DOI: 10.4161/cc.23593  0.528
2013 Freeman JA, Espinosa JM. The impact of post-transcriptional regulation in the p53 network. Briefings in Functional Genomics. 12: 46-57. PMID 23242178 DOI: 10.1093/bfgp/els058  0.569
2012 Gallant-Behm CL, Ramsey MR, Bensard CL, Nojek I, Tran J, Liu M, Ellisen LW, Espinosa JM. ΔNp63α represses anti-proliferative genes via H2A.Z deposition. Genes & Development. 26: 2325-36. PMID 23019126 DOI: 10.1101/gad.198069.112  0.552
2012 Smallwood A, Hon GC, Jin F, Henry RE, Espinosa JM, Ren B. CBX3 regulates efficient RNA processing genome-wide. Genome Research. 22: 1426-36. PMID 22684280 DOI: 10.1101/Gr.124818.111  0.436
2012 Sullivan KD, Padilla-Just N, Henry RE, Porter CC, Kim J, Tentler JJ, Eckhardt SG, Tan AC, DeGregori J, Espinosa JM. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nature Chemical Biology. 8: 646-54. PMID 22660439 DOI: 10.1038/Nchembio.965  0.524
2012 Sullivan KD, Gallant-Behm CL, Henry RE, Fraikin JL, Espinosa JM. The p53 circuit board. Biochimica Et Biophysica Acta. 1825: 229-44. PMID 22333261 DOI: 10.1016/J.Bbcan.2012.01.004  0.524
2012 Henry RE, Andrysik Z, París R, Galbraith MD, Espinosa JM. A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX. The Embo Journal. 31: 1266-78. PMID 22246181 DOI: 10.1038/emboj.2011.498  0.451
2012 Espinosa JM. Get back TFIIF, don't let me Gdown1. Molecular Cell. 45: 3-5. PMID 22244325 DOI: 10.1016/j.molcel.2011.12.016  0.31
2011 Galbraith MD, Espinosa JM. Lessons on transcriptional control from the serum response network. Current Opinion in Genetics & Development. 21: 160-6. PMID 21316215 DOI: 10.1016/j.gde.2011.01.011  0.407
2010 Galbraith MD, Donner AJ, Espinosa JM. CDK8: a positive regulator of transcription. Transcription. 1: 4-12. PMID 21327159 DOI: 10.4161/trns.1.1.12373  0.782
2010 Espinosa JM. The meaning of pausing. Molecular Cell. 40: 507-8. PMID 21095581 DOI: 10.1016/j.molcel.2010.11.025  0.356
2010 Gomes NP, Espinosa JM. Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes. Cell Cycle (Georgetown, Tex.). 9: 3428-37. PMID 20818159 DOI: 10.4161/Cc.9.17.12998  0.811
2010 Gomes NP, Espinosa JM. Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding. Genes & Development. 24: 1022-34. PMID 20478995 DOI: 10.1101/Gad.1881010  0.815
2010 Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, ... ... Espinosa JM, et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 140: 280-93. PMID 20141841 DOI: 10.1016/J.Cell.2009.12.041  0.317
2010 Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nature Structural & Molecular Biology. 17: 194-201. PMID 20098423 DOI: 10.1038/Nsmb.1752  0.777
2010 Gomes NP, Espinosa JM. Differential regulation of p53 target genes: it's (core promoter) elementary. Genes & Development. 24: 111-4. PMID 20080948 DOI: 10.1101/Gad.1893610  0.813
2009 Beckerman R, Donner AJ, Mattia M, Peart MJ, Manley JL, Espinosa JM, Prives C. A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes & Development. 23: 1364-77. PMID 19487575 DOI: 10.1101/Gad.1795709  0.79
2009 Knuesel MT, Meyer KD, Donner AJ, Espinosa JM, Taatjes DJ. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator. Molecular and Cellular Biology. 29: 650-61. PMID 19047373 DOI: 10.1128/Mcb.00993-08  0.732
2008 París R, Henry RE, Stephens SJ, McBryde M, Espinosa JM. Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation. Cell Cycle (Georgetown, Tex.). 7: 2427-33. PMID 18677110 DOI: 10.4161/cc.6420  0.516
2008 Wade M, Rodewald LW, Espinosa JM, Wahl GM. BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. Cell Cycle (Georgetown, Tex.). 7: 1973-82. PMID 18604177 DOI: 10.4161/Cc.7.13.6072  0.358
2008 Meyer KD, Donner AJ, Knuesel MT, York AG, Espinosa JM, Taatjes DJ. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. The Embo Journal. 27: 1447-57. PMID 18418385 DOI: 10.1038/Emboj.2008.78  0.741
2008 Glover-Cutter K, Kim S, Espinosa J, Bentley DL. RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes. Nature Structural & Molecular Biology. 15: 71-8. PMID 18157150 DOI: 10.1038/Nsmb1352  0.484
2007 Donner AJ, Hoover JM, Szostek SA, Espinosa JM. Stimulus-specific transcriptional regulation within the p53 network. Cell Cycle (Georgetown, Tex.). 6: 2594-8. PMID 17957141 DOI: 10.4161/Cc.6.21.4893  0.815
2007 Donner AJ, Szostek S, Hoover JM, Espinosa JM. CDK8 is a stimulus-specific positive coregulator of p53 target genes. Molecular Cell. 27: 121-33. PMID 17612495 DOI: 10.1016/J.Molcel.2007.05.026  0.821
2006 Gomes NP, Bjerke G, Llorente B, Szostek SA, Emerson BM, Espinosa JM. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes & Development. 20: 601-12. PMID 16510875 DOI: 10.1101/Gad.1398206  0.809
2005 Gómez EB, Espinosa JM, Forsburg SL. Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing. Molecular and Cellular Biology. 25: 8887-903. PMID 16199868 DOI: 10.1128/MCB.25.20.8887-8903.2005  0.305
2003 Espinosa JM, Verdun RE, Emerson BM. p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Molecular Cell. 12: 1015-27. PMID 14580351 DOI: 10.1016/S1097-2765(03)00359-9  0.582
Low-probability matches (unlikely to be authored by this person)
2017 Liang K, Volk AG, Haug JS, Marshall SA, Woodfin AR, Bartom ET, Gilmore JM, Florens L, Washburn MP, Sullivan KD, Espinosa JM, Cannova J, Zhang J, Smith ER, Crispino JD, et al. Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia. Cell. PMID 28065413 DOI: 10.1016/J.Cell.2016.12.011  0.299
2017 Galbraith MD, Andrysik Z, Pandey A, Hoh M, Bonner EA, Hill AA, Sullivan KD, Espinosa JM. CDK8 Kinase Activity Promotes Glycolysis. Cell Reports. 21: 1495-1506. PMID 29117556 DOI: 10.1016/J.Celrep.2017.10.058  0.298
2018 Abraham CG, Ludwig MP, Andrysik Z, Pandey A, Joshi M, Galbraith MD, Sullivan KD, Espinosa JM. ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. Cell Reports. 24: 3224-3236. PMID 30232004 DOI: 10.1016/J.Celrep.2018.08.058  0.289
2008 Espinosa JM. Histone H2B ubiquitination: the cancer connection. Genes & Development. 22: 2743-9. PMID 18923072 DOI: 10.1101/gad.1732108  0.288
1999 Espinosa J, Martinetto H, Portal D, D'Angelo M, Torres HN, Flawiá MM. Factors from Trypanosoma cruzi interacting with AP-1 sequences. The Journal of Eukaryotic Microbiology. 46: 516-21. PMID 10519220 DOI: 10.1111/J.1550-7408.1999.Tb06069.X  0.282
2022 Freitas KA, Belk JA, Sotillo E, Quinn PJ, Ramello MC, Malipatlolla M, Daniel B, Sandor K, Klysz D, Bjelajac J, Xu P, Burdsall KA, Tieu V, Duong VT, Donovan MG, ... ... Espinosa JM, et al. Enhanced T cell effector activity by targeting the Mediator kinase module. Science (New York, N.Y.). 378: eabn5647. PMID 36356142 DOI: 10.1126/science.abn5647  0.272
2003 Portal D, Espinosa JM, Lobo GS, Kadener S, Pereira CA, De La Mata M, Tang Z, Lin RJ, Kornblihtt AR, Baralle FE, Flawiá MM, Torres HN. An early ancestor in the evolution of splicing: a Trypanosoma cruzi serine-arginine-rich protein (TcSR) is functional in cis-splicing. Molecular and Biochemical Parasitology. 127: 37-46. PMID 12615334 DOI: 10.1016/S0166-6851(02)00301-8  0.256
2016 Nichol JN, Galbraith MD, Kleinman CL, Espinosa JM, Miller WH. NPM and BRG1 Mediate Transcriptional Resistance to Retinoic Acid in Acute Promyelocytic Leukemia. Cell Reports. 14: 2938-49. PMID 26997274 DOI: 10.1016/J.Celrep.2016.02.074  0.256
1995 Paveto C, Pereira C, Espinosa J, Montagna AE, Farber M, Esteva M, Flawiá MM, Torres HN. The nitric oxide transduction pathway in Trypanosoma cruzi. The Journal of Biological Chemistry. 270: 16576-9. PMID 7542649 DOI: 10.1074/Jbc.270.28.16576  0.255
2018 Fleenor CJ, Arends T, Lei H, Åhsberg J, Okuyama K, Kuruvilla J, Cristobal S, Rabe JL, Pandey A, Danhorn T, Straign D, Espinosa JM, Warming S, Pietras EM, Sigvardsson M, et al. Zinc Finger Protein 521 regulates early hematopoiesis through cell extrinsic mechanisms in the bone marrow microenvironment. Molecular and Cellular Biology. PMID 29915154 DOI: 10.1128/Mcb.00603-17  0.248
2016 Ferreyra-Solari N, Belforte FS, Canedo L, Videla-Richardson GA, Espinosa JM, Rossi M, Serna E, Riudavets MA, Martinetto H, Sevlever G, Perez-Castro C. The NSL chromatin-modifying complex subunit KANSL2 regulates cancer stem-like properties in glioblastoma that contribute to tumorigenesis. Cancer Research. PMID 27406830 DOI: 10.1158/0008-5472.CAN-15-3159  0.245
2013 Mellert H, Espinosa JM. Tumor suppression by p53: is apoptosis important or not? Cell Reports. 3: 1335-6. PMID 23726020 DOI: 10.1016/j.celrep.2013.05.011  0.237
2019 Oliphant MUJ, Vincent MY, Galbraith MD, Pandey A, Zaberezhnyy V, Rudra P, Johnson KR, Costello JC, Ghosh D, DeGregori J, Espinosa JM, Ford HL. Six2 mediates late-stage metastasis via direct regulation of Sox2 and induction of a cancer stem cell program. Cancer Research. PMID 30606720 DOI: 10.1158/0008-5472.Can-18-1791  0.228
2019 Wheeler LJ, Watson ZL, Qamar L, Yamamoto TM, Sawyer BT, Sullivan KD, Khanal S, Joshi M, Ferchaud-Roucher V, Smith H, Vanderlinden LA, Brubaker SW, Caino CM, Kim H, Espinosa JM, et al. Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination. Iscience. 19: 474-491. PMID 31437751 DOI: 10.1016/J.Isci.2019.07.049  0.228
2016 Andrews FH, Tong Q, Sullivan KD, Cornett EM, Zhang Y, Ali M, Ahn J, Pandey A, Guo AH, Strahl BD, Costello JC, Espinosa JM, Rothbart SB, Kutateladze TG. Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase. Cell Reports. 16: 3195-207. PMID 27653685 DOI: 10.1016/J.Celrep.2016.08.050  0.224
2020 Espinosa JM. Transcriptional control by enhancers: working remotely for improved performance. Transcription. 11: 1-2. PMID 32054432 DOI: 10.1080/21541264.2020.1724673  0.219
1997 Pereira C, Paveto C, Espinosa J, Alonso G, Flawiá MM, Torres HN. Control of Trypanosoma cruzi epimastigote motility through the nitric oxide pathway. The Journal of Eukaryotic Microbiology. 44: 155-6. PMID 9109262 DOI: 10.1111/J.1550-7408.1997.Tb05952.X  0.216
2021 Klein JA, Li Z, Rampam S, Cardini J, Ayoub A, Shaw P, Rachubinski AL, Espinosa JM, Zeldich E, Haydar TF. Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs With Trisomy 21. Frontiers in Cellular Neuroscience. 15: 794675. PMID 35058753 DOI: 10.3389/fncel.2021.794675  0.216
2015 Sullivan KD, Nakagawa A, Xue D, Espinosa JM. Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells. Cell Cycle (Georgetown, Tex.). 14: 1771-8. PMID 25853217 DOI: 10.1080/15384101.2015.1026518  0.215
2003 Portal D, Lobo GS, Kadener S, Prasad J, Espinosa JM, Pereira CA, Tang Z, Lin RJ, Manley JL, Kornblihtt AR, Flawiá MM, Torres HN. Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases. Molecular and Biochemical Parasitology. 127: 9-21. PMID 12615332 DOI: 10.1016/S0166-6851(02)00299-2  0.215
2014 Thorburn J, Andrysik Z, Staskiewicz L, Gump J, Maycotte P, Oberst A, Green DR, Espinosa JM, Thorburn A. Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels. Cell Reports. 7: 45-52. PMID 24685133 DOI: 10.1016/J.Celrep.2014.02.036  0.214
2018 Procházková J, Strapáčová S, Svržková L, Andrysík Z, Hýžďalová M, Hrubá E, Pěnčíková K, Líbalová H, Topinka J, Kléma J, Espinosa JM, Vondráček J, Machala M. Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands. Toxicology Letters. PMID 29704546 DOI: 10.1016/j.toxlet.2018.04.024  0.211
2007 Kalet BT, McBryde MB, Espinosa JM, Koch TH. Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism. Journal of Medicinal Chemistry. 50: 4493-500. PMID 17696516 DOI: 10.1021/Jm070569B  0.182
2023 Linder SJ, Bernasocchi T, Martínez-Pastor B, Sullivan KD, Galbraith MD, Lewis CA, Ferrer CM, Boon R, Silveira GG, Cho HM, Vidoudez C, Shroff S, Oliveira-Costa JP, Ross KN, Massri R, ... ... Espinosa JM, et al. Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells. Nature Metabolism. PMID 37957387 DOI: 10.1038/s42255-023-00919-3  0.178
2023 Wolin AR, Vincent MY, Hotz T, Purdy SC, Rosenbaum SR, Hughes CJ, Hsu JY, Oliphant MUJ, Armstrong B, Wessells V, Varella-Garcia M, Galbraith MD, Pierce A, Wang D, Venkataraman S, ... ... Espinosa JM, et al. EYA2 Tyrosine Phosphatase Inhibition Reduces MYC and Prevents Medulloblastoma Progression. Neuro-Oncology. PMID 37486991 DOI: 10.1093/neuonc/noad128  0.178
2013 Nakashima M, Nandakumar J, Sullivan KD, Espinosa JM, Cech TR. Inhibition of telomerase recruitment and cancer cell death. The Journal of Biological Chemistry. 288: 33171-80. PMID 24097987 DOI: 10.1074/Jbc.M113.518175  0.171
2016 Espinosa JM. Revisiting lncRNAs: How Do You Know Yours Is Not an eRNA? Molecular Cell. 62: 1-2. PMID 27058782 DOI: 10.1016/j.molcel.2016.03.022  0.17
2017 Espinosa JM. On the Origin of lncRNAs: Missing Link Found. Trends in Genetics : Tig. PMID 28778681 DOI: 10.1016/j.tig.2017.07.005  0.165
2023 Fridman V, Sillau S, Ritchie A, Bockhorst J, Coughlan C, Araya P, Espinosa JM, Smith K, Lange EM, Lange LA, El Ghormli L, Drews KL, Zeitler P, Reusch JEB. Plasma Neurofilament Light Chain Concentrations are Elevated in Youth-onset Type 2 Diabetes and Associate with Neuropathy. Journal of the Peripheral Nervous System : Jpns. PMID 37341347 DOI: 10.1111/jns.12575  0.161
2019 Powers RK, Culp-Hill R, Ludwig MP, Smith KP, Waugh KA, Minter R, Tuttle KD, Lewis HC, Rachubinski AL, Granrath RE, Carmona-Iragui M, Wilkerson RB, Kahn DE, Joshi M, Lleó A, ... ... Espinosa JM, et al. Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors. Nature Communications. 10: 4766. PMID 31628327 DOI: 10.1038/S41467-019-12739-9  0.159
2023 Muñoz-Bernart M, Budnik N, Castro A, Manzi M, Monge ME, Pioli J, Defranchi S, Parrilla G, Santilli JP, Davies K, Espinosa JM, Kobayashi K, Vigliano C, Perez-Castro C. Correction: S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) inhibits lung cancer tumorigenesis by regulating cell plasticity. Biology Direct. 18: 13. PMID 36978189 DOI: 10.1186/s13062-023-00367-9  0.159
2021 Rossi FA, Enriqué Steinberg JH, Calvo Roitberg EH, Joshi MU, Pandey A, Abba MC, Dufrusine B, Buglioni S, De Laurenzi V, Sala G, Lattanzio R, Espinosa JM, Rossi M. USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer. Oncogenesis. 10: 28. PMID 33714979 DOI: 10.1038/s41389-021-00318-x  0.153
2003 Espinosa JM, Portal D, Lobo GS, Pereira CA, Alonso GD, Gómez EB, Lan GH, Pomar RV, Flawiá MM, Torres HN. Trypanosoma cruzi poly-zinc finger protein: a novel DNA/RNA-binding CCHC-zinc finger protein. Molecular and Biochemical Parasitology. 131: 35-44. PMID 12967710 DOI: 10.1016/S0166-6851(03)00187-7  0.152
2022 Galbraith MD, Kinning KT, Sullivan KD, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter R, Jordan KR, Russell S, Dzieciatkowska M, Reisz JA, Gamboni F, Cendali F, Ghosh T, ... ... Espinosa JM, et al. Specialized interferon action in COVID-19. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35217532 DOI: 10.1073/pnas.2116730119  0.144
2023 Jewett CE, McCurdy BL, O'Toole ET, Stemm-Wolf AJ, Given KS, Lin CH, Olsen V, Martin W, Reinholdt L, Espinosa JM, Sullivan KD, Macklin WB, Prekeris R, Pearson CG. Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development. Elife. 12. PMID 36656118 DOI: 10.7554/eLife.78202  0.141
2020 Tuttle KD, Waugh KA, Araya P, Minter R, Orlicky DJ, Ludwig M, Andrysik Z, Burchill MA, Tamburini BAJ, Sempeck C, Smith K, Granrath R, Tracy D, Baxter J, Espinosa JM, et al. JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome. Cell Reports. 33: 108407. PMID 33207208 DOI: 10.1016/j.celrep.2020.108407  0.137
2021 Rossi FA, Calvo Roitberg EH, Enriqué Steinberg JH, Joshi MU, Espinosa JM, Rossi M. HERC1 Regulates Breast Cancer Cells Migration and Invasion. Cancers. 13. PMID 33804079 DOI: 10.3390/cancers13061309  0.136
2023 Muñoz-Bernart M, Budnick N, Castro A, Manzi M, Monge ME, Pioli J, Defranchi S, Parrilla G, Santilli JP, Davies K, Espinosa JM, Kobayashi K, Vigliano C, Perez-Castro C. S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) inhibits lung cancer tumorigenesis by regulating cell plasticity. Biology Direct. 18: 8. PMID 36872327 DOI: 10.1186/s13062-023-00364-y  0.134
2019 Araya P, Waugh KA, Sullivan KD, Núñez NG, Roselli E, Smith KP, Granrath RE, Rachubinski AL, Enriquez Estrada B, Butcher ET, Minter R, Tuttle KD, Bruno TC, Maccioni M, Espinosa JM. Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity. Proceedings of the National Academy of Sciences of the United States of America. PMID 31699819 DOI: 10.1073/Pnas.1908129116  0.13
2019 Rachubinski AL, Estrada BE, Norris D, Dunnick CA, Boldrick JC, Espinosa JM. Janus kinase inhibition in Down syndrome: 2 cases of therapeutic benefit for alopecia areata. Jaad Case Reports. 5: 365-367. PMID 31008170 DOI: 10.1016/J.Jdcr.2019.02.007  0.128
2018 Galati DF, Sullivan KD, Pham AT, Espinosa JM, Pearson CG. Trisomy 21 Represses Cilia Formation and Function. Developmental Cell. PMID 30100262 DOI: 10.1016/J.Devcel.2018.07.008  0.123
2023 Chi C, Knight WE, Riching AS, Zhang Z, Tatavosian R, Zhuang Y, Moldovan R, Rachubinski AL, Gao D, Xu H, Espinosa JM, Song K. Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling. Iscience. 26: 107012. PMID 37360690 DOI: 10.1016/j.isci.2023.107012  0.123
2021 Galbraith MD, Kinning KT, Sullivan KD, Baxter R, Araya P, Jordan KR, Russell S, Smith KP, Granrath RE, Shaw JR, Dzieciatkowska M, Ghosh T, Monte AA, D'Alessandro A, Hansen KC, ... ... Espinosa JM, et al. Seroconversion stages COVID19 into distinct pathophysiological states. Elife. 10. PMID 33724185 DOI: 10.7554/eLife.65508  0.122
2024 Fortea J, McGlinchey E, Espinosa JM, Rafii MS. Addressing challenges in health care and research for people with Down syndrome. Lancet (London, England). PMID 38521088 DOI: 10.1016/S0140-6736(24)00478-1  0.12
2020 Galbraith MD, Kinning KT, Sullivan KD, Baxter R, Araya P, Jordan KR, Russell S, Smith KP, Granrath RE, Shaw J, Dzieciatkowska M, Ghosh T, Monte AA, D'Alessandro A, Hansen KC, ... ... Espinosa JM, et al. Seroconversion stages COVID19 into distinct pathophysiological states. Medrxiv : the Preprint Server For Health Sciences. PMID 33330890 DOI: 10.1101/2020.12.05.20244442  0.119
2019 Waugh KA, Araya P, Pandey A, Jordan KR, Smith KP, Granrath RE, Khanal S, Butcher ET, Estrada BE, Rachubinski AL, McWilliams JA, Minter R, Dimasi T, Colvin KL, Baturin D, ... ... Espinosa JM, et al. Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome. Cell Reports. 29: 1893-1908.e4. PMID 31722205 DOI: 10.1016/J.Celrep.2019.10.038  0.117
2022 McCurdy BL, Jewett CE, Stemm-Wolf AJ, Duc HN, Joshi M, Espinosa JM, Prekeris R, Pearson CG. Trisomy 21 increases microtubules and disrupts centriolar satellite localization. Molecular Biology of the Cell. mbcE21100517T. PMID 35476505 DOI: 10.1091/mbc.E21-10-0517-T  0.116
2023 Galbraith MD, Rachubinski AL, Smith KP, Araya P, Waugh KA, Enriquez-Estrada B, Worek K, Granrath RE, Kinning KT, Paul Eduthan N, Ludwig MP, Hsieh EWY, Sullivan KD, Espinosa JM. Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition. Science Advances. 9: eadg6218. PMID 37379383 DOI: 10.1126/sciadv.adg6218  0.105
2017 Sullivan KD, Evans D, Pandey A, Hraha TH, Smith KP, Markham N, Rachubinski AL, Wolter-Warmerdam K, Hickey F, Espinosa JM, Blumenthal T. Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation. Scientific Reports. 7: 14818. PMID 29093484 DOI: 10.1038/S41598-017-13858-3  0.101
2023 Waugh KA, Minter R, Baxter J, Chi C, Galbraith MD, Tuttle KD, Eduthan NP, Kinning KT, Andrysik Z, Araya P, Dougherty H, Dunn LN, Ludwig M, Schade KA, Tracy D, ... ... Espinosa JM, et al. Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model. Nature Genetics. PMID 37277650 DOI: 10.1038/s41588-023-01399-7  0.097
2015 Warren CJ, Van Doorslaer K, Pandey A, Espinosa JM, Pyeon D. Role of the host restriction factor APOBEC3 on papillomavirus evolution. Virus Evolution. 1. PMID 27570633 DOI: 10.1093/Ve/Vev015  0.093
2022 Araya P, Kinning KT, Coughlan C, Smith KP, Granrath RE, Enriquez-Estrada BA, Worek K, Sullivan KD, Rachubinski AL, Wolter-Warmerdam K, Hickey F, Galbraith MD, Potter H, Espinosa JM. IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome. Cell Reports. 41: 111883. PMID 36577365 DOI: 10.1016/j.celrep.2022.111883  0.085
2021 Sullivan KD, Galbraith MD, Kinning KT, Bartsch KW, Levinsky NC, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter RM, Jordan KR, Russell SA, Dzieciatkowska ME, Reisz JA, Gamboni F, ... ... Espinosa JM, et al. The COVIDome Explorer researcher portal. Cell Reports. 109527. PMID 34348131 DOI: 10.1016/j.celrep.2021.109527  0.085
2023 Thomas SN, Niemeyer BF, Jimenez-Valdes RJ, Kaiser AJ, Espinosa JM, Sullivan KD, Goodspeed A, Costello JC, Alder JK, Cañas-Arranz R, García-Sastre A, Benam KH. Down syndrome is associated with altered frequency and functioning of tracheal multiciliated cells, and response to influenza virus infection. Iscience. 26: 107361. PMID 37554445 DOI: 10.1016/j.isci.2023.107361  0.084
2021 Sullivan KD, Galbraith MD, Kinning KT, Bartsch K, Levinsky N, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter R, Jordan KR, Russell S, Dzieciatkowska M, Reisz JA, Gamboni F, ... ... Espinosa JM, et al. The COVIDome Explorer Researcher Portal. Medrxiv : the Preprint Server For Health Sciences. PMID 33758879 DOI: 10.1101/2021.03.04.21252945  0.084
2017 Culp-Hill R, Zheng C, Reisz JA, Smith K, Rachubinski A, Nemkov T, Butcher E, Granrath R, Hansen KC, Espinosa JM, D'Alessandro A. Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging. Blood Advances. 1: 2776-2780. PMID 29296929 DOI: 10.1182/Bloodadvances.2017011957  0.082
2023 D'Alessandro A, Nouraie SM, Zhang Y, Cendali F, Gamboni F, Reisz JA, Zhang X, Bartsch KW, Galbraith MD, Espinosa JM, Gordeuk VR, Gladwin MT. Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients, as a function of therapeutic transfusion and hydroxyurea treatment. Biorxiv : the Preprint Server For Biology. PMID 37066337 DOI: 10.1101/2023.04.05.535693  0.077
2023 D'Alessandro A, Nouraie SM, Zhang Y, Cendali F, Gamboni F, Reisz JA, Zhang X, Bartsch KW, Galbraith MD, Espinosa JM, Gordeuk VR, Gladwin MT. Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients as a function of therapeutic transfusion and hydroxyurea treatment. Haematologica. PMID 37439373 DOI: 10.3324/haematol.2023.283288  0.07
2017 Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC. EXOSOMAL BIOMARKERS IN DOWN SYNDROME AND ALZHEIMER'S DISEASE. Free Radical Biology & Medicine. PMID 28882786 DOI: 10.1016/J.Freeradbiomed.2017.08.028  0.066
2003 Martinez-Urtaza J, Saco M, Hernandez-Cordova G, Lozano A, Garcia-Martin O, Espinosa J. Identification of Salmonella serovars isolated from live molluscan shellfish and their significance in the marine environment. Journal of Food Protection. 66: 226-32. PMID 12597481  0.044
2020 Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, et al. Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32544310 DOI: 10.1002/Alz.12112  0.043
2023 Lesteberg KE, Araya P, Waugh KA, Chauhan L, Espinosa JM, Beckham JD. Severely ill and high-risk COVID-19 patients exhibit increased peripheral circulation of CD62L+ and perforin+ T cells. Frontiers in Immunology. 14: 1113932. PMID 36817450 DOI: 10.3389/fimmu.2023.1113932  0.038
2020 Espinosa JM. Down Syndrome and COVID-19: A Perfect Storm? Cell Reports Medicine. 1: 100019. PMID 32501455 DOI: 10.1016/j.xcrm.2020.100019  0.037
2021 Pham AT, Rachubinski AL, Enriquez-Estrada B, Worek K, Griffith M, Espinosa JM. JAK inhibition for treatment of psoriatic arthritis in Down syndrome. Rheumatology (Oxford, England). PMID 33630031 DOI: 10.1093/rheumatology/keab203  0.036
2024 Santoro JD, Khoshnood MM, Jafarpour S, Nguyen L, Boyd NK, Vogel BN, Kammeyer R, Patel L, Manning MA, Rachubinski AL, Filipink RA, Baumer NT, Santoro SL, Franklin C, Tamrazi B, ... ... Espinosa JM, et al. Neuroimaging abnormalities associated with immunotherapy responsiveness in Down syndrome regression disorder. Annals of Clinical and Translational Neurology. PMID 38375538 DOI: 10.1002/acn3.52023  0.034
1990 Crespo C, Garcia-Caballero T, Beiras A, Espinosa J. Evidence from sperm ultrastructure that the mussel of Galician estuaries is Mytilus galloprovincialis Lamarck Journal of Molluscan Studies. 56: 127-128. DOI: 10.1093/mollus/56.1.127  0.026
2023 DeBoer EM, Wolter-Warmerdam K, Deterding RR, Marmolejo J, Blumenthal T, Espinosa JM, Hickey F, Wagner BD. Cardiopulmonary Phenotypes and Protein Signatures in Children With Down Syndrome. Clinical Pediatrics. 99228231179453. PMID 37306037 DOI: 10.1177/00099228231179453  0.024
2020 Vita S, Di Bari V, Corpolongo A, Goletti D, Espinosa J, Petracca S, Palmieri F, Nicastri E. Down Syndrome patients with COVID-19 pneumonia: a high-risk category for unfavourable outcome. International Journal of Infectious Diseases : Ijid : Official Publication of the International Society For Infectious Diseases. PMID 33271290 DOI: 10.1016/j.ijid.2020.11.188  0.019
2013 Gallant-Behm CL, Espinosa JM. How does ΔNp63α drive cancer? Epigenomics. 5: 5-7. PMID 23414311 DOI: 10.2217/epi.12.78  0.019
2021 Liggett LA, Galbraith MD, Smith KP, Sullivan KD, Granrath RE, Enriquez-Estrada B, Kinning KT, Shaw JR, Rachubinski AL, Espinosa JM, DeGregori J. Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation. Blood Advances. 5: 1791-1796. PMID 33787858 DOI: 10.1182/bloodadvances.2020003858  0.016
2012 Fernández-Reiriz M, Range P, Álvarez-Salgado X, Espinosa J, Labarta U. Tolerance of juvenile Mytilus galloprovincialis to experimental seawater acidification Marine Ecology Progress Series. 454: 65-74. DOI: 10.3354/MEPS09660  0.011
2020 Deigendesch N, Hirsiger JR, Bigler MB, Ghosh A, Harder D, Jauch A, Espinosa JM, Recher M, Navarini A, Daikeler T, Berger CT. Tumoural soft tissue calcification in Down syndrome: association with heterozygous germline SAMD9 mutation and hyperactive type I interferon signaling. Rheumatology (Oxford, England). PMID 32594144 DOI: 10.1093/rheumatology/keaa301  0.01
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