| Year |
Citation |
Score |
| 2024 |
Swahari V, Nakamura A, Hollville E, Hung YH, Kanke M, Kurtz CL, Caravia XM, Roiz-Valle D, He S, Krishnamurthy J, Kapoor S, Prasad V, Flowers C, Beck M, Baran-Gale J, ... Sharpless N, et al. miR-29 is an important driver of aging-related phenotypes. Communications Biology. 7: 1055. PMID 39191864 DOI: 10.1038/s42003-024-06735-z |
0.52 |
|
| 2024 |
Souroullas GP, Jeck WR, Parker JS, Simon JM, Liu JY, Paulk J, Xiong J, Clark KS, Fedoriw Y, Qi J, Burd CE, Bradner JE, Sharpless NE. Author Correction: An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation. Nature Medicine. PMID 38383796 DOI: 10.1038/s41591-024-02867-1 |
0.639 |
|
| 2019 |
Liu JY, Souroullas GP, Diekman BO, Krishnamurthy J, Hall BM, Sorrentino JA, Parker JS, Sessions GA, Gudkov AV, Sharpless NE. Cells exhibiting strong promoter activation in vivo display features of senescence. Proceedings of the National Academy of Sciences of the United States of America. PMID 30683717 DOI: 10.1073/Pnas.1818313116 |
0.688 |
|
| 2018 |
Zhao X, Little P, Hoyle AP, Pegna GJ, Hayward MC, Ivanova A, Parker JS, Marron DL, Soloway MG, Jo H, Salazar AH, Papakonstantinou MP, Bouchard DM, Jefferys SR, Hoadley KA, ... ... Sharpless NE, et al. The Prognostic Significance of Low-Frequency Somatic Mutations in Metastatic Cutaneous Melanoma. Frontiers in Oncology. 8: 584. PMID 30662871 DOI: 10.3389/Fonc.2018.00584 |
0.332 |
|
| 2018 |
Diekman BO, Sessions GA, Collins JA, Knecht AK, Strum SL, Mitin NK, Carlson CS, Loeser RF, Sharpless NE. Expression of p16 is a biomarker of chondrocyte aging but does not cause osteoarthritis. Aging Cell. e12771. PMID 29744983 DOI: 10.1111/Acel.12771 |
0.38 |
|
| 2017 |
Sewastianik T, Jiang M, Sukhdeo K, Patel SS, Roberts K, Kang Y, Alduaij A, Dennis PS, Lawney B, Liu R, Song Z, Xiong J, Zhang Y, Lemieux ME, Pinkus GS, ... ... Sharpless NE, et al. Constitutive Ras signaling and Ink4a/Arf inactivation cooperate during the development of B-ALL in mice. Blood Advances. 1: 2361-2374. PMID 29296886 DOI: 10.1182/Bloodadvances.2017012211 |
0.345 |
|
| 2017 |
Brighton HE, Angus SP, Bo T, Roques J, Tagliatela AC, Darr D, Karagoz K, Sciaky N, Gatza M, Sharpless NE, Johnson GL, Bear JE. New mechanisms of resistance to MEK inhibitors in melanoma revealed by intravital imaging. Cancer Research. PMID 29180473 DOI: 10.1158/0008-5472.Can-17-1653 |
0.343 |
|
| 2017 |
Liu W, Snell JM, Jeck WR, Hoadley KA, Wilkerson MD, Parker JS, Patel N, Mlombe YB, Mulima G, Liomba NG, Wolf LL, Shores CG, Gopal S, Sharpless NE. Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis. Jci Insight. 2. PMID 29148985 DOI: 10.1172/jci.insight.98457 |
0.614 |
|
| 2017 |
Deng J, Wang ES, Jenkins RW, Li S, Dries R, Yates K, Chhabra S, Huang W, Liu H, Aref AR, Ivanova E, Paweletz CP, Bowden M, Zhou CW, Herter-Sprie GS, ... ... Sharpless NE, et al. CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation. Cancer Discovery. PMID 29101163 DOI: 10.1158/2159-8290.Cd-17-0915 |
0.67 |
|
| 2017 |
Hong A, Moriceau G, Sun L, Lomeli S, Piva M, Damoiseaux R, Holmen SL, Sharpless NE, Hugo W, Lo RS. Exploiting drug addiction mechanisms to select against MAPKi-resistant melanoma. Cancer Discovery. PMID 28923912 DOI: 10.1158/2159-8290.Cd-17-0682 |
0.34 |
|
| 2017 |
He S, Sharpless NE. Senescence in Health and Disease. Cell. 169: 1000-1011. PMID 28575665 DOI: 10.1016/J.Cell.2017.05.015 |
0.638 |
|
| 2017 |
He S, Roberts PJ, Sorrentino JA, Bisi JE, Storrie-White H, Tiessen RG, Makhuli KM, Wargin WA, Tadema H, van Hoogdalem EJ, Strum JC, Malik R, Sharpless NE. Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion. Science Translational Medicine. 9. PMID 28446688 DOI: 10.1126/Scitranslmed.Aal3986 |
0.75 |
|
| 2017 |
Souroullas GP, Fedoriw Y, Staudt LM, Sharpless NE. Lkb1 deletion in murine B lymphocytes promotes cell death and cancer. Experimental Hematology. PMID 28435024 DOI: 10.1016/J.Exphem.2017.04.005 |
0.362 |
|
| 2017 |
Strulov Shachar S, Deal AM, Mitin N, Nyrop KA, Lee JT, Choi SK, Pulley W, Bell EF, Christopher N, Williams GR, Carey LA, Anders CK, Jolly TA, Dees EC, Reeder-Hayes KE, ... ... Sharpless NE, et al. Changes in p16INK4a (p16) expression, a biomarker of aging, in peripheral blood T-cells (PBTC) in patients receiving anthracycline (A) vs non-anthracycline (NoA) chemotherapy (CRx) for early-stage breast cancer (EBC). Journal of Clinical Oncology. 35: 10060-10060. DOI: 10.1200/Jco.2017.35.15_Suppl.10060 |
0.368 |
|
| 2017 |
Sewastianik T, Jiang M, Sukhdeo K, Patel S, Kang Y, Alduaij A, Dennis PS, Xiong J, Pinkus GS, Rich JN, Lemieux ME, Sharpless NE, Carrasco RD. Constitutive Activation of Ras and Inactivation of Ink4a/Arf Allele Induce a Fully Penetrant B-Cell Acute Lymphoblastic Leukemia Phenotype in Mice Blood. 130: 1222-1222. DOI: 10.1182/Blood.V130.Suppl_1.1222.1222 |
0.315 |
|
| 2016 |
Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, ... ... Sharpless NE, et al. Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discovery. PMID 27979832 DOI: 10.1158/2159-8290.Cd-16-0241 |
0.386 |
|
| 2016 |
Liu W, Snell JM, Jeck WR, Hoadley KA, Wilkerson MD, Parker JS, Patel N, Mlombe YB, Mulima G, Liomba NG, Wolf LL, Shores CG, Gopal S, Sharpless NE. Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis. Jci Insight. 1: e88755. PMID 27734031 DOI: 10.1172/Jci.Insight.88755 |
0.697 |
|
| 2016 |
Wood WA, Krishnamurthy J, Mitin N, Torrice C, Parker JS, Snavely AC, Shea TC, Serody JS, Sharpless NE. Chemotherapy and Stem Cell Transplantation Increase p16(INK4a) Expression, a Biomarker of T-cell Aging. Ebiomedicine. PMID 27591832 DOI: 10.1016/J.Ebiom.2016.08.029 |
0.338 |
|
| 2016 |
Palacio L, Krishnan V, Le NL, Sharpless NE, Beauséjour CM. Sustained p16(INK4a) expression is required to prevent IR-induced tumorigenesis in mice. Oncogene. PMID 27568978 DOI: 10.1038/Onc.2016.298 |
0.368 |
|
| 2016 |
King SJ, Asokan SB, Haynes EM, Zimmerman SP, Rotty JD, Alb JG, Tagliatela A, Blake DR, Lebedeva IP, Marston D, Johnson HE, Parsons M, Sharpless NE, Kuhlman B, Haugh JM, et al. Lamellipodia are critical for haptotactic sensing and response. Journal of Cell Science. PMID 27173494 DOI: 10.1242/Jcs.184507 |
0.336 |
|
| 2016 |
Souroullas GP, Jeck WR, Parker JS, Simon JM, Liu JY, Paulk J, Xiong J, Clark KS, Fedoriw Y, Qi J, Burd CE, Bradner JE, Sharpless NE. An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation. Nature Medicine. PMID 27135738 DOI: 10.1038/Nm.4092 |
0.703 |
|
| 2016 |
Seifert BA, O'Daniel JM, Amin K, Marchuk DS, Patel NM, Parker JS, Hoyle AP, Mose LE, Marron A, Hayward MC, Bizon C, Wilhelmsen KC, Evans JP, Earp HS, Sharpless N, et al. Germline Analysis from Tumor-Germline Sequencing Dyads to identify clinically actionable secondary findings. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27083775 DOI: 10.1158/1078-0432.Ccr-16-0015 |
0.331 |
|
| 2016 |
Dumond JB, Francis O, Cottrell M, Trezza C, Prince HM, Mollan K, Sykes C, Torrice C, White N, Malone S, Wang R, Van Dam C, Patterson KB, Hudgens MG, Sharpless NE, et al. Tenofovir/emtricitabine metabolites and endogenous nucleotide exposures are associated with p16(INK4a) expression in subjects on combination therapy. Antiviral Therapy. PMID 26731175 DOI: 10.3851/Imp3017 |
0.325 |
|
| 2016 |
Sharpless NE. Abstract IA11: Transient CDK4/6 inhibition protects hematopoietic progenitors from chemotherapy-induced exhaustion Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Cellcycle16-Ia11 |
0.366 |
|
| 2016 |
Grilley-Olsen J, Keith K, Hayward M, Dees E, Deal A, Ivanova A, Benbow J, Parker J, Patel N, Eberhard D, Mieczkowski P, Weck K, Hayes D, Muss H, Jolly T, ... ... Sharpless N, et al. Abstract PD6-07: Genomic sequencing in metastatic breast cancer patients to inform clinical practice at the University of North Carolina at Chapel Hill Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-Pd6-07 |
0.317 |
|
| 2016 |
Lee W, Jo H, Yin X, Eberhard DA, Patel NM, Hayward MC, Salazar AH, Parker JS, Kim WY, Earp HS, Sharpless NE, Hayes DN. Abstract 4499: Integration of targeted RNA sequencing to targeted DNA sequencing for the characterization of clinically relevant variants in a population of thousands of patients treated on clinical trial Cancer Research. 76: 4499-4499. DOI: 10.1158/1538-7445.Am2016-4499 |
0.323 |
|
| 2016 |
Brighton HE, Angus S, Bo T, Darr D, Sharpless NE, Johnson GL, Bear JE. Abstract 4382: Intravital imaging of endogenous BRAFV600E melanoma reveals plasticity of tumor response and resistance to trametinib over time Cancer Research. 76: 4382-4382. DOI: 10.1158/1538-7445.Am2016-4382 |
0.362 |
|
| 2016 |
Roberts P, He S, Schvartsman G, Patil T, Sorrentio J, Bisi J, Hoyer R, Schuster S, Strum J, Heymach J, Ferrarotto R, Sharpless N, Shapiro G, Malik R. G1T28, a CDK4/6 inhibitor, preserves T lymphocyte function from damage by cytotoxic chemotherapy European Journal of Cancer. 69: S143-S144. DOI: 10.1016/S0959-8049(16)33026-X |
0.567 |
|
| 2015 |
Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Krager K, Ponnappan U, et al. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nature Medicine. PMID 26657143 DOI: 10.1038/Nm.4010 |
0.366 |
|
| 2015 |
Sharpless NE, Sherr CJ. Forging a signature of in vivo senescence. Nature Reviews. Cancer. 15: 397-408. PMID 26105537 DOI: 10.1038/Nrc3960 |
0.315 |
|
| 2015 |
Zhao X, Wang A, Walter V, Patel NM, Eberhard DA, Hayward MC, Salazar AH, Jo H, Soloway MG, Wilkerson MD, Parker JS, Yin X, Zhang G, Siegel MB, Rosson GB, ... ... Sharpless NE, et al. Combined Targeted DNA Sequencing in Non-Small Cell Lung Cancer (NSCLC) Using UNCseq and NGScopy, and RNA Sequencing Using UNCqeR for the Detection of Genetic Aberrations in NSCLC. Plos One. 10: e0129280. PMID 26076459 DOI: 10.1371/Journal.Pone.0129280 |
0.337 |
|
| 2015 |
Souroullas GP, Sharpless NE. mTOR signaling in melanoma: oncogene-induced pseudo-senescence? Cancer Cell. 27: 3-5. PMID 25584887 DOI: 10.1016/J.Ccell.2014.12.005 |
0.375 |
|
| 2015 |
Moschos SJ, Zhao X, Liu W, Trembath DG, Krauze MT, Long GV, Sivalingham B, Scolyer RA, Kirkwood JM, Hamilton RL, Hayes DN, Sharpless NE. Whole exome paraffin sequencing (WEPS) of same-patient (pt) primary, extracranial, and melanoma brain metastases (PEB) to identify new driver and clonal evolution genetic events. Journal of Clinical Oncology. 33: e20033-e20033. DOI: 10.1200/Jco.2015.33.15_Suppl.E20033 |
0.318 |
|
| 2015 |
Park SI, Lin CP, Dittmer DP, Angus SP, Wang GG, Fedoriw YD, Darr DB, Roth DP, Sharpless NE, Damania B. Alisertib, an Aurora a Kinase Inhibitor, Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-Overexpressing Lymphoma Cells Blood. 126: 1551-1551. DOI: 10.1182/Blood.V126.23.1551.1551 |
0.417 |
|
| 2015 |
Park SI, Lin CP, Foote M, Parton T, Darr DB, Roth D, Bhatt AP, Dittmer DP, Sharpless NE, Damania B. Abstract B39: Multitarget approach against PI3K, Aurora kinase, and BRD4 leads to improved antitumor activity in Myc-overexpressing lymphoma cells Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-B39 |
0.41 |
|
| 2015 |
Muss H, Deal A, Hurria A, Mitin N, Torrice C, Janakiraman K, Jolly T, Williams G, Alston S, West J, Zavala L, Katheria V, Sharpless N. Abstract P6-08-34:p16INK4aexpression and chemotherapy toxicity in women with early stage breast cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P6-08-34 |
0.339 |
|
| 2015 |
Hayes DN, Grilley-Olson JE, Eberhard DA, Patel NM, Parker JS, Weck KE, Kim WY, Hayward MC, Earp HS, Sharpless NE. Abstract CT133: The impact of gene panel sequencing on clinical care in patients with cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Ct133 |
0.323 |
|
| 2015 |
Sorrentino JA, He S, Bisi JE, Roberts PJ, Strum JC, Sharpless NE. Abstract 941: G1T28-1, a novel CDK4/6 inhibitor, protects murine hematopoietic stem and progenitor cells from cytotoxic chemotherapy Cancer Research. 75: 941-941. DOI: 10.1158/1538-7445.Am2015-941 |
0.734 |
|
| 2015 |
Darr D, Sharpless N, Perou C, Villena FPd, Miller D, Bendt K, Hursting SD. Abstract 2285: Germline genetic variation modulates tumor latency and response to therapy in a mouse model of basal-like breast cancer Cancer Research. 75: 2285-2285. DOI: 10.1158/1538-7445.Am2015-2285 |
0.305 |
|
| 2014 |
Chan KT, Asokan SB, King SJ, Bo T, Dubose ES, Liu W, Berginski ME, Simon JM, Davis IJ, Gomez SM, Sharpless NE, Bear JE. LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues. The Journal of Cell Biology. 207: 299-315. PMID 25349262 DOI: 10.1083/Jcb.201404067 |
0.302 |
|
| 2014 |
Burd CE, Liu W, Huynh MV, Waqas MA, Gillahan JE, Clark KS, Fu K, Martin BL, Jeck WR, Souroullas GP, Darr DB, Zedek DC, Miley MJ, Baguley BC, Campbell SL, ... Sharpless NE, et al. Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. Cancer Discovery. 4: 1418-29. PMID 25252692 DOI: 10.1158/2159-8290.Cd-14-0729 |
0.688 |
|
| 2014 |
Zhao N, Wilkerson MD, Shah U, Yin X, Wang A, Hayward MC, Roberts P, Lee CB, Parsons AM, Thorne LB, Haithcock BE, Grilley-Olson JE, Stinchcombe TE, Funkhouser WK, Wong KK, ... Sharpless NE, et al. Alterations of LKB1 and KRAS and risk of brain metastasis: comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma. Lung Cancer (Amsterdam, Netherlands). 86: 255-61. PMID 25224251 DOI: 10.1016/J.Lungcan.2014.08.013 |
0.319 |
|
| 2014 |
Sorrentino JA, Sanoff HK, Sharpless NE. Defining the toxicology of aging. Trends in Molecular Medicine. 20: 375-84. PMID 24880613 DOI: 10.1016/J.Molmed.2014.04.004 |
0.657 |
|
| 2014 |
Jeck WR, Sharpless NE. Detecting and characterizing circular RNAs. Nature Biotechnology. 32: 453-61. PMID 24811520 DOI: 10.1038/Nbt.2890 |
0.651 |
|
| 2014 |
Sanoff HK, Deal AM, Krishnamurthy J, Torrice C, Dillon P, Sorrentino J, Ibrahim JG, Jolly TA, Williams G, Carey LA, Drobish A, Gordon BB, Alston S, Hurria A, Kleinhans K, ... ... Sharpless NE, et al. Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer. Journal of the National Cancer Institute. 106: dju057. PMID 24681605 DOI: 10.1093/Jnci/Dju057 |
0.675 |
|
| 2014 |
Jeck WR, Parker J, Carson CC, Shields JM, Sambade MJ, Peters EC, Burd CE, Thomas NE, Chiang DY, Liu W, Eberhard DA, Ollila D, Grilley-Olson J, Moschos S, Neil Hayes D, ... Sharpless NE, et al. Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma. Pigment Cell & Melanoma Research. 27: 653-63. PMID 24628946 DOI: 10.1111/Pcmr.12238 |
0.69 |
|
| 2014 |
Shao L, Feng W, Li H, Gardner D, Luo Y, Wang Y, Liu L, Meng A, Sharpless NE, Zhou D. Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner. Blood. 123: 3105-15. PMID 24622326 DOI: 10.1182/Blood-2013-07-515619 |
0.318 |
|
| 2014 |
Sorrentino JA, Krishnamurthy J, Tilley S, Alb JG, Burd CE, Sharpless NE. p16INK4a reporter mice reveal age-promoting effects of environmental toxicants. The Journal of Clinical Investigation. 124: 169-73. PMID 24334456 DOI: 10.1172/Jci70960 |
0.661 |
|
| 2014 |
Earp HS, Darr D, Zimmermann A, Clark K, Sharpless NE, Bergmeier W, Zhang W, Wang X, DeRyckere D, Frye S, Graham D. Abstract 947: A small molecule Mer tyrosine kinase inhibitor (UNC MerTKi) effectively inhibits growth of murine melanoma Cancer Research. 74: 947-947. DOI: 10.1158/1538-7445.Am2014-947 |
0.392 |
|
| 2014 |
Darr D, Clark KS, Phillips JH, Pinheiro E, Sriram V, Xiong J, Jordan J, Sharpless NE, Perou C, Moschos S. Abstract 5024: mDX400, the murine analog against the anti-PD1 antibody MK-347 is active in immunocompetent, autochthonous murine models of melanoma and breast cancer Cancer Research. 74: 5024-5024. DOI: 10.1158/1538-7445.Am2014-5024 |
0.334 |
|
| 2014 |
Bear JE, Brighton HE, Sharpless NE, Darr DB, Clark KS. Abstract 4943: Visualization of endogenous melanoma initiation and progression using intravital microscopy Cancer Research. 74: 4943-4943. DOI: 10.1158/1538-7445.Am2014-4943 |
0.369 |
|
| 2014 |
Angus SP, Stuhlmiller TJ, Reuther R, Pham TT, Granger DA, Darr DB, Jordan JL, Moschos SJ, Johnson GL, Sharpless NE. Abstract 4761: Defining the adaptive kinome response to BRAF and MEK inhibition in melanoma Cancer Research. 74: 4761-4761. DOI: 10.1158/1538-7445.Am2014-4761 |
0.359 |
|
| 2013 |
Wang Y, Sharpless N, Chang S. p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses. The Journal of Clinical Investigation. 123: 4489-501. PMID 24091330 DOI: 10.1172/Jci69574 |
0.352 |
|
| 2013 |
Nakada Y, Stewart TG, Peña CG, Zhang S, Zhao N, Bardeesy N, Sharpless NE, Wong KK, Hayes DN, Castrillon DH. The LKB1 tumor suppressor as a biomarker in mouse and human tissues. Plos One. 8: e73449. PMID 24086281 DOI: 10.1371/Journal.Pone.0073449 |
0.353 |
|
| 2013 |
Souroullas GP, Sharpless NE. Stem cells: Down's syndrome link to ageing. Nature. 501: 325-6. PMID 24025769 DOI: 10.1038/Nature12558 |
0.335 |
|
| 2013 |
Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, ... ... Sharpless NE, et al. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discovery. 3: 870-9. PMID 23715154 DOI: 10.1158/2159-8290.Cd-13-0015 |
0.363 |
|
| 2013 |
Anders CK, Adamo B, Karginova O, Deal AM, Rawal S, Darr D, Schorzman A, Santos C, Bash R, Kafri T, Carey L, Miller CR, Perou CM, Sharpless N, Zamboni WC. Pharmacokinetics and efficacy of PEGylated liposomal doxorubicin in an intracranial model of breast cancer. Plos One. 8: e61359. PMID 23650496 DOI: 10.1371/Journal.Pone.0061359 |
0.309 |
|
| 2013 |
Newgard CB, Sharpless NE. Coming of age: molecular drivers of aging and therapeutic opportunities. The Journal of Clinical Investigation. 123: 946-50. PMID 23454756 DOI: 10.1172/Jci68833 |
0.316 |
|
| 2013 |
Burd CE, Sorrentino JA, Clark KS, Darr DB, Krishnamurthy J, Deal AM, Bardeesy N, Castrillon DH, Beach DH, Sharpless NE. Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model. Cell. 152: 340-51. PMID 23332765 DOI: 10.1016/J.Cell.2012.12.010 |
0.698 |
|
| 2013 |
Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE. Circular RNAs are abundant, conserved, and associated with ALU repeats Rna. 19: 141-157. PMID 23249747 DOI: 10.1261/Rna.035667.112 |
0.741 |
|
| 2013 |
Chan KT, Asokan SB, Bo T, Berginski ME, Liu W, Cochran SD, Sharpless NE, Bear JE. Abstract C14: Loss of haptotaxis facilitates invasion in LKB1-deficient melanoma Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-C14 |
0.352 |
|
| 2013 |
Um S, Chen J, Lee C, Sharpless NE, Roberts PJ, Hayes DN. Abstract 2400: Differential phosphorylation of signaling targets as a function of RAS mutation status and tumor histology in non-small cell lung cancer. Cancer Research. 73: 2400-2400. DOI: 10.1158/1538-7445.Am2013-2400 |
0.388 |
|
| 2013 |
Burd C, Jeck WR, Fu K, Clark KS, Xiong JC, Souroullas GP, Sharpless NE. Abstract 1087: Differential oncogenicity of N-RAS mutations in melanoma. Cancer Research. 73: 1087-1087. DOI: 10.1158/1538-7445.Am2013-1087 |
0.677 |
|
| 2013 |
Sharpless NE. Abstract CN03-01: Drug testing in genetically engineered murine models. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-Cn03-01 |
0.334 |
|
| 2012 |
Troy A, Sharpless NE. Genetic "lnc"-age of noncoding RNAs to human disease Journal of Clinical Investigation. 122: 3837-3840. PMID 23093789 DOI: 10.1172/Jci66645 |
0.303 |
|
| 2012 |
Combest AJ, Roberts PJ, Dillon PM, Sandison K, Hanna SK, Ross C, Habibi S, Zamboni B, Müller M, Brunner M, Sharpless NE, Zamboni WC. Genetically engineered cancer models, but not xenografts, faithfully predict anticancer drug exposure in melanoma tumors. The Oncologist. 17: 1303-16. PMID 22993143 DOI: 10.1634/Theoncologist.2012-0274 |
0.326 |
|
| 2012 |
Liu W, Sharpless NE. Senescence-escape in melanoma. Pigment Cell & Melanoma Research. 25: 408-9. PMID 22900268 DOI: 10.1111/J.1755-148X.2012.01021.X |
0.332 |
|
| 2012 |
Jeck WR, Siebold AP, Sharpless NE. Review: a meta-analysis of GWAS and age-associated diseases. Aging Cell. 11: 727-31. PMID 22888763 DOI: 10.1111/J.1474-9726.2012.00871.X |
0.661 |
|
| 2012 |
Roberts PJ, Usary JE, Darr DB, Dillon PM, Pfefferle AD, Whittle MC, Duncan JS, Johnson SM, Combest AJ, Jin J, Zamboni WC, Johnson GL, Perou CM, Sharpless NE. Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 5290-303. PMID 22872574 DOI: 10.1158/1078-0432.Ccr-12-0563 |
0.57 |
|
| 2012 |
Nelson JA, Krishnamurthy J, Menezes P, Liu Y, Hudgens MG, Sharpless NE, Eron JJ. Expression of p16(INK4a) as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy. Aging Cell. 11: 916-8. PMID 22738669 DOI: 10.1111/J.1474-9726.2012.00856.X |
0.307 |
|
| 2012 |
Liu W, Monahan KB, Pfefferle AD, Shimamura T, Sorrentino J, Chan KT, Roadcap DW, Ollila DW, Thomas NE, Castrillon DH, Miller CR, Perou CM, Wong KK, Bear JE, Sharpless NE. LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell. 21: 751-64. PMID 22698401 DOI: 10.1016/J.Ccr.2012.03.048 |
0.742 |
|
| 2012 |
Duncan JS, Whittle MC, Nakamura K, Abell AN, Midland AA, Zawistowski JS, Johnson NL, Granger DA, Jordan NV, Darr DB, Usary J, Kuan PF, Smalley DM, Major B, He X, ... ... Sharpless NE, et al. Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell. 149: 307-21. PMID 22500798 DOI: 10.1016/J.Cell.2012.02.053 |
0.352 |
|
| 2012 |
Chen Z, Cheng K, Walton Z, Wang Y, Ebi H, Shimamura T, Liu Y, Tupper T, Ouyang J, Li J, Gao P, Woo MS, Xu C, Yanagita M, Altabef A, ... ... Sharpless NE, et al. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature. 483: 613-7. PMID 22425996 DOI: 10.1038/Nature10937 |
0.337 |
|
| 2012 |
Roberts PJ, Bisi JE, Strum JC, Combest AJ, Darr DB, Usary JE, Zamboni WC, Wong KK, Perou CM, Sharpless NE. Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy. Journal of the National Cancer Institute. 104: 476-87. PMID 22302033 DOI: 10.1093/Jnci/Djs002 |
0.334 |
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| 2012 |
Kim WY, Sharpless NE. Drug efficacy testing in mice. Current Topics in Microbiology and Immunology. 355: 19-38. PMID 21823029 DOI: 10.1007/82_2011_160 |
0.319 |
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| 2011 |
Muss HB, Krishnamurthy J, Alston SM, Lacy AC, Jolly TA, Williams G, Carey LA, Dees EC, Anders CK, Irvin WJ, Sharpless NE. P16(INK4a)expression after chemotherapy in older women with early-stage breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 9002. PMID 28021723 DOI: 10.1200/Jco.2011.29.15_Suppl.9002 |
0.347 |
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| 2011 |
Liu Y, Johnson SM, Fedoriw Y, Rogers AB, Yuan H, Krishnamurthy J, Sharpless NE. Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes. Blood. 117: 3257-67. PMID 21245485 DOI: 10.1182/Blood-2010-09-304402 |
0.595 |
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| 2011 |
Cardenas JC, Owens AP, Krishnamurthy J, Sharpless NE, Whinna HC, Church FC. Overexpression of the cell cycle inhibitor p16INK4a promotes a prothrombotic phenotype following vascular injury in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 827-33. PMID 21233453 DOI: 10.1161/Atvbaha.110.221721 |
0.376 |
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| 2011 |
Carey LA, Sharpless NE. PARP and cancer--if it's broke, don't fix it. The New England Journal of Medicine. 364: 277-9. PMID 21208102 DOI: 10.1056/Nejme1012546 |
0.328 |
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| 2011 |
Shao L, Feng W, Li H, Wang Y, Sharpless N, Zhou D. Ionizing Radiation Induces Hematopoietic Stem Cell Senescence and Long-Term Bone Marrow Suppression in a p16Ink4a/Arf-Independent manner Blood. 118: 1345-1345. DOI: 10.1182/Blood.V118.21.1345.1345 |
0.354 |
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| 2011 |
Burd CE, Clark K, Sharpless NE. Abstract 5271: p16-LUC: an in vivo reporter allele for de novo tumor formation and therapeutic response Cancer Research. 71: 5271-5271. DOI: 10.1158/1538-7445.Am2011-5271 |
0.435 |
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| 2011 |
Anders C, Adamo B, Walsh, Karginova O, Darr D, Deal A, Santos C, Bash R, Hanna S, Carey L, Miller C, Sharpless N, Zamboni W. P4-17-04: Pharmacokinetic Disposition of PEGylated Liposomal Doxorubicin Compared with Non-Liposomal Doxorubicin in an Intracranial Breast Cancer Murine Model. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-P4-17-04 |
0.332 |
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| 2010 |
Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z, Sharpless NE. Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. Plos Genetics. 6: e1001233. PMID 21151960 DOI: 10.1371/Journal.Pgen.1001233 |
0.676 |
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| 2010 |
Monahan KB, Rozenberg GI, Krishnamurthy J, Johnson SM, Liu W, Bradford MK, Horner J, Depinho RA, Sharpless NE. Somatic p16(INK4a) loss accelerates melanomagenesis. Oncogene. 29: 5809-17. PMID 20697345 DOI: 10.1038/Onc.2010.314 |
0.674 |
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| 2010 |
Rozenberg GI, Monahan KB, Torrice C, Bear JE, Sharpless NE. Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation. Melanoma Research. 20: 361-71. PMID 20679910 DOI: 10.1097/Cmr.0B013E328336Ee17 |
0.599 |
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| 2010 |
Sharpless NE. Hot topics in stem cells and self-renewal: 2010. Aging Cell. 9: 457-61. PMID 20579010 DOI: 10.1111/J.1474-9726.2010.00592.X |
0.344 |
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| 2010 |
Johnson SM, Torrice CD, Bell JF, Monahan KB, Jiang Q, Wang Y, Ramsey MR, Jin J, Wong KK, Su L, Zhou D, Sharpless NE. Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition. The Journal of Clinical Investigation. 120: 2528-36. PMID 20577054 DOI: 10.1172/Jci41402 |
0.687 |
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| 2010 |
Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, ... ... Sharpless NE, et al. Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell. 17: 547-59. PMID 20541700 DOI: 10.1016/J.Ccr.2010.04.026 |
0.317 |
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| 2010 |
Burd CE, Sharpless NE. What's so special about RB? Cancer Cell. 17: 313-4. PMID 20385355 DOI: 10.1016/J.Ccr.2010.03.010 |
0.345 |
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| 2009 |
Tsygankov D, Liu Y, Sanoff HK, Sharpless NE, Elston TC. A quantitative model for age-dependent expression of the p16INK4a tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. 106: 16562-7. PMID 19805338 DOI: 10.1073/Pnas.0904405106 |
0.346 |
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| 2009 |
Kim WY, Perera S, Zhou B, Carretero J, Yeh JJ, Heathcote SA, Jackson AL, Nikolinakos P, Ospina B, Naumov G, Brandstetter KA, Weigman VJ, Zaghlul S, Hayes DN, Padera RF, ... ... Sharpless NE, et al. HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. The Journal of Clinical Investigation. 119: 2160-70. PMID 19662677 DOI: 10.1172/Jci38443 |
0.37 |
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| 2009 |
Wong ES, Le Guezennec X, Demidov ON, Marshall NT, Wang ST, Krishnamurthy J, Sharpless NE, Dunn NR, Bulavin DV. p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age. Developmental Cell. 17: 142-9. PMID 19619499 DOI: 10.1016/J.Devcel.2009.05.009 |
0.401 |
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| 2009 |
Liu Y, Sharpless NE. Tumor suppressor mechanisms in immune aging. Current Opinion in Immunology. 21: 431-9. PMID 19535234 DOI: 10.1016/J.Coi.2009.05.011 |
0.382 |
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| 2009 |
Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Ibrahim JG, Thomas NE, Sharpless NE. Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging. Aging Cell. 8: 439-48. PMID 19485966 DOI: 10.1111/J.1474-9726.2009.00489.X |
0.354 |
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| 2009 |
Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Mohlke KL, Ibrahim JG, Thomas NE, Sharpless NE. INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. Plos One. 4: e5027. PMID 19343170 DOI: 10.1371/Journal.Pone.0005027 |
0.316 |
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| 2009 |
Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, Boren T, Shimamura T, Miller DS, Sharpless NE, Bardeesy N, Kwiatkowski DJ, Schorge JO, Wong KK, Castrillon DH. Somatic LKB1 mutations promote cervical cancer progression. Plos One. 4: e5137. PMID 19340305 DOI: 10.1371/Journal.Pone.0005137 |
0.351 |
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| 2009 |
Sharpless NE, Schatten G. Stem cell aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 64: 202-4. PMID 19228784 DOI: 10.1093/Gerona/Gln070 |
0.315 |
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| 2009 |
Stirewalt DL, Choi YE, Sharpless NE, Pogosova-Agadjanyan EL, Cronk MR, Yukawa M, Larson EB, Wood BL, Appelbaum FR, Radich JP, Heimfeld S. Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells. Leukemia. 23: 391-3. PMID 18596738 DOI: 10.1038/Leu.2008.176 |
0.367 |
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| 2009 |
Carretero J, Shimamura T, Rikova K, Gu T, Borgman CL, Buttarazzi S, McNamara KL, Brandstetter KA, Silva JC, Shapiro GI, Castrillon DH, Maira M, García‐Echeverría C, Kim CF, Bardeesy N, ... Sharpless NE, et al. Abstract B103: Integrative genomic and proteomic analyses identify novel targets for Lkb1 deficient metastatic lung tumors Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-B103 |
0.35 |
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| 2009 |
Stirewalt DL, Choi YE, Sharpless NE, Pogosova-Agadjanyan EL, Cronk MR, Yukawa M, Larson EB, Wood BL, Appelbaum FR, Radich JP, Heimfeld S. Erratum: Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells Leukemia. 23: 430-430. DOI: 10.1038/Leu.2008.293 |
0.325 |
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| 2008 |
Shah U, Sharpless NE, Hayes DN. LKB1 and lung cancer: more than the usual suspects. Cancer Research. 68: 3562-5. PMID 18483235 DOI: 10.1158/0008-5472.Can-07-6620 |
0.352 |
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| 2008 |
Kim WY, Sharpless NE. VHL inactivation: a new road to senescence. Cancer Cell. 13: 295-7. PMID 18394552 DOI: 10.1016/J.Ccr.2008.03.012 |
0.351 |
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| 2008 |
Kaufmann WK, Nevis KR, Qu P, Ibrahim JG, Zhou T, Zhou Y, Simpson DA, Helms-Deaton J, Cordeiro-Stone M, Moore DT, Thomas NE, Hao H, Liu Z, Shields JM, Scott GA, ... Sharpless NE, et al. Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression. The Journal of Investigative Dermatology. 128: 175-87. PMID 17597816 DOI: 10.1038/Sj.Jid.5700935 |
0.327 |
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| 2008 |
Tothova Z, Sykes SM, Leeman DS, Horner JW, Sharpless N, DePinho RA, Gilliland DG. p16INK4a Is a Key Downstream Mediator of the Deleterious Effects of FoxO Deficiency on Maintenance of the Hematopoietic Stem Cell Compartment. Blood. 112: 1405-1405. DOI: 10.1182/Blood.V112.11.1405.1405 |
0.346 |
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| 2008 |
Sharpless NE. Elizabeth Blackburn and the story of telomeres
Deciphering the ends of DNA Journal of Clinical Investigation. 118: 1211-1211. DOI: 10.1172/Jci35246 |
0.331 |
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| 2007 |
Petermann KB, Rozenberg GI, Zedek D, Groben P, McKinnon K, Buehler C, Kim WY, Shields JM, Penland S, Bear JE, Thomas NE, Serody JS, Sharpless NE. CD200 is induced by ERK and is a potential therapeutic target in melanoma. The Journal of Clinical Investigation. 117: 3922-9. PMID 18008004 DOI: 10.1172/Jci32163 |
0.322 |
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| 2007 |
Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nature Reviews. Molecular Cell Biology. 8: 703-13. PMID 17717515 DOI: 10.1038/Nrm2241 |
0.367 |
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| 2007 |
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, ... ... Sharpless NE, et al. LKB1 modulates lung cancer differentiation and metastasis. Nature. 448: 807-10. PMID 17676035 DOI: 10.1038/Nature06030 |
0.344 |
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| 2007 |
Ha L, Ichikawa T, Anver M, Dickins R, Lowe S, Sharpless NE, Krimpenfort P, Depinho RA, Bennett DC, Sviderskaya EV, Merlino G. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proceedings of the National Academy of Sciences of the United States of America. 104: 10968-73. PMID 17576930 DOI: 10.1073/Pnas.0611638104 |
0.379 |
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| 2007 |
Ramsey MR, Krishnamurthy J, Pei XH, Torrice C, Lin W, Carrasco DR, Ligon KL, Xiong Y, Sharpless NE. Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues. Cancer Research. 67: 4732-41. PMID 17510401 DOI: 10.1158/0008-5472.Can-06-3437 |
0.356 |
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| 2007 |
Shields JM, Thomas NE, Cregger M, Berger AJ, Leslie M, Torrice C, Hao H, Penland S, Arbiser J, Scott G, Zhou T, Bar-Eli M, Bear JE, Der CJ, Kaufmann WK, ... ... Sharpless NE, et al. Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma. Cancer Research. 67: 1502-12. PMID 17308088 DOI: 10.1158/0008-5472.Can-06-3311 |
0.365 |
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| 2007 |
Penland SK, Keku TO, Torrice C, He X, Krishnamurthy J, Hoadley KA, Woosley JT, Thomas NE, Perou CM, Sandler RS, Sharpless NE. RNA expression analysis of formalin-fixed paraffin-embedded tumors. Laboratory Investigation; a Journal of Technical Methods and Pathology. 87: 383-91. PMID 17297435 DOI: 10.1038/Labinvest.3700529 |
0.313 |
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| 2007 |
Sharpless NE, DePinho RA. Cancer biology: gone but not forgotten. Nature. 445: 606-7. PMID 17251931 DOI: 10.1038/Nature05567 |
0.35 |
|
| 2007 |
Bell JF, Sharpless NE. Telomeres, p21 and the cancer-aging hypothesis. Nature Genetics. 39: 11-2. PMID 17192782 DOI: 10.1038/Ng0107-11 |
0.383 |
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| 2006 |
Bardeesy N, Sharpless NE. RAS unplugged: negative feedback and oncogene-induced senescence. Cancer Cell. 10: 451-3. PMID 17157783 DOI: 10.1016/J.Ccr.2006.11.015 |
0.335 |
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| 2006 |
Ramsey MR, Sharpless NE. ROS as a tumour suppressor? Nature Cell Biology. 8: 1213-5. PMID 17077852 DOI: 10.1038/Ncb1106-1213 |
0.302 |
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| 2006 |
Kim WY, Sharpless NE. The regulation of INK4/ARF in cancer and aging. Cell. 127: 265-75. PMID 17055429 DOI: 10.1016/J.Cell.2006.10.003 |
0.39 |
|
| 2006 |
Ji H, Sharpless NE, Wong KK. EGFR targeted therapy: view from biological standpoint. Cell Cycle (Georgetown, Tex.). 5: 2072-6. PMID 16969107 DOI: 10.4161/Cc.5.18.3277 |
0.31 |
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| 2006 |
Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature. 443: 448-52. PMID 16957738 DOI: 10.1038/Nature05091 |
0.68 |
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| 2006 |
Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature. 443: 453-7. PMID 16957737 DOI: 10.1038/Nature05092 |
0.359 |
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| 2006 |
Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 443: 421-6. PMID 16957735 DOI: 10.1038/Nature05159 |
0.364 |
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| 2006 |
Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Jänne PA, ... ... Sharpless NE, et al. The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell. 9: 485-95. PMID 16730237 DOI: 10.1016/J.Ccr.2006.04.022 |
0.32 |
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| 2006 |
Paliwal S, Pande S, Kovi RC, Sharpless NE, Bardeesy N, Grossman SR. Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis. Molecular and Cellular Biology. 26: 2360-72. PMID 16508011 DOI: 10.1128/Mcb.26.6.2360-2372.2006 |
0.367 |
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| 2005 |
Sharpless NE, DePinho RA. Cancer: crime and punishment. Nature. 436: 636-7. PMID 16079829 DOI: 10.1038/436636A |
0.326 |
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| 2005 |
Sharpless NE. INK4a/ARF: a multifunctional tumor suppressor locus. Mutation Research. 576: 22-38. PMID 15878778 DOI: 10.1016/J.Mrfmmm.2004.08.021 |
0.381 |
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| 2005 |
Rünger TM, Vergilis I, Sarkar P, DePinho RA, Sharpless NE. How disruption of cell cycle regulating genes might predispose to sun-induced skin cancer. Cell Cycle (Georgetown, Tex.). 4: 643-5. PMID 15846097 DOI: 10.4161/Cc.4.5.1673 |
0.389 |
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| 2004 |
Sharpless NE. Ink4a/Arf links senescence and aging. Experimental Gerontology. 39: 1751-9. PMID 15582292 DOI: 10.1016/J.Exger.2004.06.025 |
0.426 |
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| 2004 |
Sarkar-Agrawal P, Vergilis I, Sharpless NE, DePinho RA, Rünger TM. Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF. Journal of the National Cancer Institute. 96: 1790-3. PMID 15572761 DOI: 10.1093/Jnci/Djh307 |
0.331 |
|
| 2004 |
Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE. Ink4a/Arf expression is a biomarker of aging. The Journal of Clinical Investigation. 114: 1299-307. PMID 15520862 DOI: 10.1172/Jci22475 |
0.367 |
|
| 2004 |
Sachs Z, Sharpless NE, DePinho RA, Rosenberg N. p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis. Journal of Virology. 78: 3304-11. PMID 15016851 DOI: 10.1128/Jvi.78.7.3304-3311.2004 |
0.358 |
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| 2004 |
Sharpless NE, Ramsey MR, Balasubramanian P, Castrillon DH, DePinho RA. The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis. Oncogene. 23: 379-85. PMID 14724566 DOI: 10.1038/Sj.Onc.1207074 |
0.356 |
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| 2004 |
Sharpless NE, DePinho RA. Telomeres, stem cells, senescence, and cancer. The Journal of Clinical Investigation. 113: 160-8. PMID 14722605 DOI: 10.1172/Jci20761 |
0.397 |
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| 2003 |
Sharpless NE. The persistence of senescence. Science of Aging Knowledge Environment : Sage Ke. 2003: PE24. PMID 12931012 DOI: 10.1126/Sageke.2003.33.Pe24 |
0.37 |
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| 2003 |
Sharpless NE, Kannan K, Xu J, Bosenberg MW, Chin L. Both products of the mouse INK4a/ARF locus suppress melanoma formation in vivo Oncogene. 22: 5055-5059. PMID 12902988 DOI: 10.1038/Sj.Onc.1206809 |
0.382 |
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| 2003 |
Sharpless NE, Chin L. The INK4α/ARF locus and melanoma Oncogene. 22: 3092-3098. PMID 12789286 DOI: 10.1038/Sj.Onc.1206461 |
0.353 |
|
| 2003 |
Kannan K, Sharpless NE, Xu J, O'Hagan RC, Bosenberg M, Chin L. Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model. Proceedings of the National Academy of Sciences of the United States of America. 100: 1221-5. PMID 12538879 DOI: 10.1073/Pnas.0336397100 |
0.347 |
|
| 2002 |
Kulke MH, Demetri GD, Sharpless NE, Ryan DP, Shivdasani R, Clark JS, Spiegelman BM, Kim H, Mayer RJ, Fuchs CS. A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. Cancer Journal (Sudbury, Mass.). 8: 395-9. PMID 12416897 DOI: 10.1097/00130404-200209000-00010 |
0.351 |
|
| 2002 |
Opitz OG, Harada H, Suliman Y, Rhoades B, Sharpless NE, Kent R, Kopelovich L, Nakagawa H, Rustgi AK. A mouse model of human oral-esophageal cancer. The Journal of Clinical Investigation. 110: 761-9. PMID 12235107 DOI: 10.1172/Jci15324 |
0.354 |
|
| 2002 |
Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 419: 162-7. PMID 12226664 DOI: 10.1038/Nature01045 |
0.352 |
|
| 2002 |
Sharpless NE, DePinho RA. p53: good cop/bad cop. Cell. 110: 9-12. PMID 12150992 DOI: 10.1016/S0092-8674(02)00818-8 |
0.353 |
|
| 2002 |
Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell. 1: 269-77. PMID 12086863 DOI: 10.1016/S1535-6108(02)00046-6 |
0.355 |
|
| 2002 |
Artandi SE, Alson S, Tietze MK, Sharpless NE, Ye S, Greenberg RA, Castrillon DH, Horner JW, Weiler SR, Carrasco RD, DePinho RA. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 8191-6. PMID 12034875 DOI: 10.1073/Pnas.112515399 |
0.373 |
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| 2001 |
Sharpless NE, Ferguson DO, O'Hagan RC, Castrillon DH, Lee C, Farazi PA, Alson S, Fleming J, Morton CC, Frank K, Chin L, Alt FW, DePinho RA. Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Molecular Cell. 8: 1187-96. PMID 11779495 DOI: 10.1016/S1097-2765(01)00425-7 |
0.333 |
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| 2001 |
Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature. 413: 86-91. PMID 11544531 DOI: 10.1038/35092592 |
0.401 |
|
| 2001 |
Bardeesy N, Sharpless NE, DePinho RA, Merlino G. The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model. Seminars in Cancer Biology. 11: 201-18. PMID 11407945 DOI: 10.1006/Scbi.2000.0371 |
0.327 |
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| 2001 |
Martelli F, Hamilton T, Silver DP, Sharpless NE, Bardeesy N, Rokas M, DePinho RA, Livingston DM, Grossman SR. p19ARF targets certain E2F species for degradation. Proceedings of the National Academy of Sciences of the United States of America. 98: 4455-60. PMID 11274364 DOI: 10.1073/Pnas.081061398 |
0.339 |
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| 2000 |
Opitz OG, Suliman Y, Rhoades B, Sharpless NE, Rustgi AK. The combination of cyclin D1 overexpression and p53 inactivation is critical for oral-esophageal carcinogenesis in transgenic mice Gastroenterology. 118: A768. DOI: 10.1016/S0016-5085(00)85209-9 |
0.351 |
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| 1999 |
Sharpless NE, DePinho RA. The INK4A/ARF locus and its two gene products. Current Opinion in Genetics & Development. 9: 22-30. PMID 10072356 DOI: 10.1016/S0959-437X(99)80004-5 |
0.346 |
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