| Year |
Citation |
Score |
| 2022 |
Wang S, Jain A, Novales NA, Nashner AN, Tran F, Clarke CF. Predicting and Understanding the Pathology of Single Nucleotide Variants in Human Genes. Antioxidants (Basel, Switzerland). 11. PMID 36552517 DOI: 10.3390/antiox11122308 |
0.397 |
|
| 2021 |
Latimer S, Keene SA, Stutts LR, Berger A, Bernert AC, Soubeyrand E, Wright J, Clarke CF, Block AK, Colquhoun TA, Elowsky C, Christensen A, Wilson MA, Basset GJ. A dedicated flavin-dependent monooxygenase catalyzes the hydroxylation of demethoxyubiquinone into ubiquinone (Coenzyme Q) in Arabidopsis. The Journal of Biological Chemistry. 101283. PMID 34626646 DOI: 10.1016/j.jbc.2021.101283 |
0.345 |
|
| 2021 |
Ayer A, Fazakerley DJ, Suarna C, Maghzal GJ, Sheipouri D, Lee KJ, Bradley MC, Fernández-Del-Rio L, Tumanov S, Kong SM, van der Veen JN, Yang A, Ho JWK, Clarke SG, James DE, ... ... Clarke CF, et al. Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q. Redox Biology. 46: 102127. PMID 34521065 DOI: 10.1016/j.redox.2021.102127 |
0.721 |
|
| 2021 |
Fernández-Del-Río L, Rodríguez-López S, Gutiérrez-Casado E, González-Reyes JA, Clarke CF, Burón MI, Villalba JM. Regulation of hepatic coenzyme Q biosynthesis by dietary omega-3 polyunsaturated fatty acids. Redox Biology. 46: 102061. PMID 34246922 DOI: 10.1016/j.redox.2021.102061 |
0.302 |
|
| 2021 |
Fernández-Del-Río L, Clarke CF. Coenzyme Q Biosynthesis: An Update on the Origins of the Benzenoid Ring and Discovery of New Ring Precursors. Metabolites. 11. PMID 34198496 DOI: 10.3390/metabo11060385 |
0.335 |
|
| 2021 |
Acoba MG, Alpergin ESS, Renuse S, Fernández-Del-Río L, Lu YW, Khalimonchuk O, Clarke CF, Pandey A, Wolfgang MJ, Claypool SM. The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. Cell Reports. 34: 108869. PMID 33730581 DOI: 10.1016/j.celrep.2021.108869 |
0.323 |
|
| 2020 |
Fernández-Del-Río L, Soubeyrand E, Basset GJ, Clarke CF. Metabolism of the Flavonol Kaempferol in Kidney Cells Liberates the B-ring to Enter Coenzyme Q Biosynthesis. Molecules (Basel, Switzerland). 25. PMID 32605010 DOI: 10.3390/Molecules25132955 |
0.377 |
|
| 2020 |
Awad AM, Nag A, Pham NVB, Bradley MC, Jabassini N, Nathaniel J, Clarke CF. Intragenic suppressor mutations of the COQ8 protein kinase homolog restore coenzyme Q biosynthesis and function in Saccharomyces cerevisiae. Plos One. 15: e0234192. PMID 32479562 DOI: 10.1371/Journal.Pone.0234192 |
0.807 |
|
| 2020 |
Fernández-Del-Río L, Kelly M, Contreras J, Bradley MC, James AM, Murphy MP, Payne GS, Clarke CF. Genes and lipids that impact uptake and assimilation of exogenous coenzyme Q in Saccharomyces cerevisiae. Free Radical Biology & Medicine. PMID 32387128 DOI: 10.1016/J.Freeradbiomed.2020.04.029 |
0.778 |
|
| 2020 |
Widmeier E, Yu S, Nag A, Chung YW, Nakayama M, Fernández-Del-Río L, Hugo H, Schapiro D, Buerger F, Choi WI, Helmstädter M, Kim JW, Ryu JH, Lee MG, Clarke CF, et al. ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment. Journal of the American Society of Nephrology : Jasn. PMID 32381600 DOI: 10.1681/Asn.2019070756 |
0.428 |
|
| 2020 |
Bradley MC, Yang K, Fernández-Del-Río L, Ngo J, Ayer A, Tsui HS, Novales NA, Stocker R, Shirihai OS, Barros MH, Clarke CF. deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10. The Journal of Biological Chemistry. PMID 32205446 DOI: 10.1074/Jbc.Ra119.012420 |
0.83 |
|
| 2019 |
Bernert AC, Jacobs EJ, Reinl SR, Choi CCY, Roberts Buceta PM, Culver JC, Goodspeed CR, Bradley MC, Clarke CF, Basset GJ, Shepherd JN. Recombinant RquA catalyzes the in vivo conversion of ubiquinone to rhodoquinone in Escherichia coli and Saccharomyces cerevisiae. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 31121262 DOI: 10.1016/J.Bbalip.2019.05.007 |
0.703 |
|
| 2019 |
Tsui HS, Pham NVB, Amer BR, Bradley MC, Gosschalk JE, Gallagher-Jones M, Ibarra H, Clubb RT, Blaby-Haas CE, Clarke CF. Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function. Journal of Lipid Research. PMID 31048406 DOI: 10.1194/Jlr.M093534 |
0.756 |
|
| 2019 |
Eisenberg-Bord M, Tsui HS, Antunes D, Fernández-Del-Río L, Bradley MC, Dunn CD, Nguyen TPT, Rapaport D, Clarke CF, Schuldiner M. The Endoplasmic Reticulum-Mitochondria Encounter Structure Complex Coordinates Coenzyme Q Biosynthesis. Contact (Thousand Oaks (Ventura County, Calif.)). 2: 2515256418825409. PMID 30937424 DOI: 10.1177/2515256418825409 |
0.752 |
|
| 2019 |
Widmeier E, Airik M, Hugo H, Schapiro D, Wedel J, Ghosh CC, Nakayama M, Schneider R, Awad AM, Nag A, Cho J, Schueler M, Clarke CF, Airik R, Hildebrandt F. Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression and Renal Fibrosis in Podocyte-Specific Knockout Mice. Journal of the American Society of Nephrology : Jasn. PMID 30737270 DOI: 10.1681/Asn.2018060625 |
0.397 |
|
| 2018 |
Awad AM, Bradley MC, Fernández-Del-Río L, Nag A, Tsui HS, Clarke CF. Coenzyme Q deficiencies: pathways in yeast and humans. Essays in Biochemistry. PMID 29980630 DOI: 10.1042/Ebc20170106 |
0.769 |
|
| 2018 |
Clarke CF. Insights into an Ancient Atypical Kinase Essential for Biosynthesis of Coenzyme Q. Cell Chemical Biology. 25: 123-125. PMID 29452608 DOI: 10.1016/J.Chembiol.2018.02.001 |
0.451 |
|
| 2018 |
Ayer A, Maghzal GJ, van der Veen JN, Dawes IW, Vance DE, Clarke CF, Jacobs RL, Stocker R. A potential novel pathway to regulate cellular concentrations of the redox-active lipid coenzyme Q Free Radical Biology and Medicine. 120: S71. DOI: 10.1016/J.Freeradbiomed.2018.04.236 |
0.484 |
|
| 2017 |
Awad AM, Venkataramanan S, Nag A, Galivanche AR, Bradley MC, Neves LT, Douglass S, Clarke CF, Johnson TL. Chromatin-remodeling SWI/SNF complex regulates coenzyme Q synthesis and a metabolic shift to respiration in yeast. The Journal of Biological Chemistry. 292: 14851-14866. PMID 28739803 DOI: 10.1074/Jbc.M117.798397 |
0.742 |
|
| 2017 |
He CH, Black DS, Allan CM, Meunier B, Rahman S, Clarke CF. Human COQ9 Rescues a Yeast Mutant by Enhancing Coenzyme Q Biosynthesis from 4-Hydroxybenzoic Acid and Stabilizing the CoQ-Synthome. Frontiers in Physiology. 8: 463. PMID 28736527 DOI: 10.3389/Fphys.2017.00463 |
0.75 |
|
| 2017 |
Fernández-Del-Río L, Nag A, Gutiérrez Casado E, Ariza J, Awad AM, Joseph AI, Kwon O, Verdin E, de Cabo R, Schneider C, Torres JZ, Burón MI, Clarke CF, Villalba JM. Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor. Free Radical Biology & Medicine. 110: 176-187. PMID 28603085 DOI: 10.1016/J.Freeradbiomed.2017.06.006 |
0.566 |
|
| 2016 |
Awad AM, Whitelegge JP, Srinivasan C, Sondej MA, Clarke CF. Characterization of CoQ‐Synthome proteins and binding partners, their phosphorylation status, and regulation The Faseb Journal. 30. DOI: 10.1096/Fasebj.30.1_Supplement.1134.12 |
0.533 |
|
| 2016 |
Ayer A, Maghzal GJ, Clarke CF, Dawes IW, Stocker R. What Regulates the Cellular Content of the Redox-Active Lipid Coenzyme Q? Free Radical Biology and Medicine. 100: S72. DOI: 10.1016/J.Freeradbiomed.2016.10.185 |
0.475 |
|
| 2015 |
Clarke CF, Allan CM. Biochemistry: Unexpected role for vitamin B2. Nature. 522: 427-8. PMID 26083748 DOI: 10.1038/Nature14536 |
0.598 |
|
| 2015 |
He CH, Black DS, Nguyen TP, Wang C, Srinivasan C, Clarke CF. Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid. Biochimica Et Biophysica Acta. 1851: 1227-39. PMID 26008578 DOI: 10.1016/J.Bbalip.2015.05.003 |
0.788 |
|
| 2015 |
Xie LX, Williams KJ, He CH, Weng E, Khong S, Rose TE, Kwon O, Bensinger SJ, Marbois BN, Clarke CF. Resveratrol and para-coumarate serve as ring precursors for coenzyme Q biosynthesis. Journal of Lipid Research. 56: 909-19. PMID 25681964 DOI: 10.1194/Jlr.M057919 |
0.485 |
|
| 2015 |
Allan CM, Awad AM, Johnson JS, Shirasaki DI, Wang C, Blaby-Haas CE, Merchant SS, Loo JA, Clarke CF. Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 290: 7517-34. PMID 25631044 DOI: 10.1074/Jbc.M114.633131 |
0.784 |
|
| 2015 |
Andreyev AY, Tsui HS, Milne GL, Shmanai VV, Bekish AV, Fomich MA, Pham MN, Nong Y, Murphy AN, Clarke CF, Shchepinov MS. Isotope-reinforced polyunsaturated fatty acids protect mitochondria from oxidative stress. Free Radical Biology & Medicine. 82: 63-72. PMID 25578654 DOI: 10.1016/J.Freeradbiomed.2014.12.023 |
0.331 |
|
| 2014 |
Nguyen TP, Casarin A, Desbats MA, Doimo M, Trevisson E, Santos-Ocaña C, Navas P, Clarke CF, Salviati L. Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis. Biochimica Et Biophysica Acta. 1841: 1628-38. PMID 25152161 DOI: 10.1016/J.Bbalip.2014.08.007 |
0.798 |
|
| 2014 |
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, ... ... Clarke CF, et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 510: 397-401. PMID 24828042 DOI: 10.1038/Nature13264 |
0.332 |
|
| 2014 |
Clarke CF, Rowat AC, Gober JW. Osmotic stress: Is CoQ a membrane stabilizer? Nature Chemical Biology. 10: 242-3. PMID 24643237 DOI: 10.1038/Nchembio.1478 |
0.328 |
|
| 2014 |
He CH, Xie LX, Allan CM, Tran UC, Clarke CF. Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants. Biochimica Et Biophysica Acta. 1841: 630-44. PMID 24406904 DOI: 10.1016/J.Bbalip.2013.12.017 |
0.865 |
|
| 2014 |
He C, Black D, Clarke C. Characterization of the Function of Coq9 in Yeast Free Radical Biology and Medicine. 76: S105. DOI: 10.1016/J.Freeradbiomed.2014.10.258 |
0.339 |
|
| 2013 |
Ashraf S, Gee HY, Woerner S, Xie LX, Vega-Warner V, Lovric S, Fang H, Song X, Cattran DC, Avila-Casado C, Paterson AD, Nitschké P, Bole-Feysot C, Cochat P, Esteve-Rudd J, ... ... Clarke CF, et al. ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. The Journal of Clinical Investigation. 123: 5179-89. PMID 24270420 DOI: 10.1172/Jci69000 |
0.401 |
|
| 2013 |
Gasser DL, Winkler CA, Peng M, An P, McKenzie LM, Kirk GD, Shi Y, Xie LX, Marbois BN, Clarke CF, Kopp JB. Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10. American Journal of Physiology. Renal Physiology. 305: F1228-38. PMID 23926186 DOI: 10.1152/Ajprenal.00143.2013 |
0.409 |
|
| 2013 |
Allan CM, Hill S, Morvaridi S, Saiki R, Johnson JS, Liau WS, Hirano K, Kawashima T, Ji Z, Loo JA, Shepherd JN, Clarke CF. A conserved START domain coenzyme Q-binding polypeptide is required for efficient Q biosynthesis, respiratory electron transport, and antioxidant function in Saccharomyces cerevisiae. Biochimica Et Biophysica Acta. 1831: 776-791. PMID 23270816 DOI: 10.1016/J.Bbalip.2012.12.007 |
0.792 |
|
| 2013 |
He C, Xie L, Allan C, Tran U, Clarke C. PSS281 - Coenzyme Q supplementation or Over-Expression of the Yeast Coq8 Putative Kinase Stabilizes Multi-Subunit Coq Polypeptide Complexes in Yeast Coq Null Mutants Free Radical Biology and Medicine. 65. DOI: 10.1016/J.Freeradbiomed.2013.10.705 |
0.528 |
|
| 2012 |
Gomez F, Monsalve GC, Tse V, Saiki R, Weng E, Lee L, Srinivasan C, Frand AR, Clarke CF. Delayed accumulation of intestinal coliform bacteria enhances life span and stress resistance in Caenorhabditis elegans fed respiratory deficient E. coli. Bmc Microbiology. 12: 300. PMID 23256533 DOI: 10.1186/1471-2180-12-300 |
0.598 |
|
| 2012 |
Nguyen TP, Clarke CF. Folate status of gut microbiome affects Caenorhabditis elegans lifespan. Bmc Biology. 10: 66. PMID 22849295 DOI: 10.1186/1741-7007-10-66 |
0.642 |
|
| 2012 |
Gomez F, Saiki R, Chin R, Srinivasan C, Clarke CF. Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation. Gene. 506: 106-16. PMID 22735617 DOI: 10.1016/J.Gene.2012.06.023 |
0.774 |
|
| 2012 |
Hill S, Lamberson CR, Xu L, To R, Tsui HS, Shmanai VV, Bekish AV, Awad AM, Marbois BN, Cantor CR, Porter NA, Clarke CF, Shchepinov MS. Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation. Free Radical Biology & Medicine. 53: 893-906. PMID 22705367 DOI: 10.1016/J.Freeradbiomed.2012.06.004 |
0.326 |
|
| 2012 |
Xie LX, Ozeir M, Tang JY, Chen JY, Jaquinod SK, Fontecave M, Clarke CF, Pierrel F. Overexpression of the Coq8 kinase in Saccharomyces cerevisiae coq null mutants allows for accumulation of diagnostic intermediates of the coenzyme Q6 biosynthetic pathway. The Journal of Biological Chemistry. 287: 23571-81. PMID 22593570 DOI: 10.1074/Jbc.M112.360354 |
0.569 |
|
| 2012 |
Rahman S, Clarke CF, Hirano M. 176th ENMC International Workshop: diagnosis and treatment of coenzyme Q₁₀ deficiency. Neuromuscular Disorders : Nmd. 22: 76-86. PMID 21723727 DOI: 10.1016/J.Nmd.2011.05.001 |
0.411 |
|
| 2012 |
Collinson E, Chan K, Maghzal G, Cantley J, Suarna C, Dunn L, Ni J, Midwinter R, Hamid H, Newington D, Lam Y, James D, Clarke C, Ng M, Stocker⁎ R. Heme oxygenase-1 regulates mitochondrial coenzyme Q and reactive oxygen species formation -- possible implications for the metabolic reprogramming in response to hypoxia Free Radical Biology and Medicine. 53: S66-S67. DOI: 10.1016/j.freeradbiomed.2012.08.559 |
0.31 |
|
| 2012 |
Ozeir M, Xie LX, Chehade MH, Tang JY, Chen JY, Jaquinod S, Fontecave M, Clarke CF, Pierrel F. In vivo accumulation of coenzyme Q biosynthetic intermediates and aminated analogs in the yeast Saccharomyces cerevisiae Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1817: S92. DOI: 10.1016/J.Bbabio.2012.06.249 |
0.596 |
|
| 2011 |
Clarke CF. Coq6 hydroxylase: unmasked and bypassed. Chemistry & Biology. 18: 1069-70. PMID 21944743 DOI: 10.1016/J.Chembiol.2011.09.006 |
0.45 |
|
| 2011 |
Pfeiffer M, Kayzer EB, Yang X, Abramson E, Kenaston MA, Lago CU, Lo HH, Sedensky MM, Lunceford A, Clarke CF, Wu SJ, McLeod C, Finkel T, Morgan PG, Mills EM. Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport. The Journal of Biological Chemistry. 286: 37712-20. PMID 21862587 DOI: 10.1074/Jbc.M111.271452 |
0.808 |
|
| 2011 |
Falk MJ, Polyak E, Zhang Z, Peng M, King R, Maltzman JS, Okwuego E, Horyn O, Nakamaru-Ogiso E, Ostrovsky J, Xie LX, Chen JY, Marbois B, Nissim I, Clarke CF, et al. Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice. Embo Molecular Medicine. 3: 410-27. PMID 21567994 DOI: 10.1002/Emmm.201100149 |
0.399 |
|
| 2011 |
Xie LX, Hsieh EJ, Watanabe S, Allan CM, Chen JY, Tran UC, Clarke CF. Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants. Biochimica Et Biophysica Acta. 1811: 348-60. PMID 21296186 DOI: 10.1016/J.Bbalip.2011.01.009 |
0.846 |
|
| 2011 |
Hill S, Hirano K, Shmanai VV, Marbois BN, Vidovic D, Bekish AV, Kay B, Tse V, Fine J, Clarke CF, Shchepinov MS. Isotope-reinforced polyunsaturated fatty acids protect yeast cells from oxidative stress. Free Radical Biology & Medicine. 50: 130-8. PMID 20955788 DOI: 10.1016/J.Freeradbiomed.2010.10.690 |
0.474 |
|
| 2011 |
Devarajan A, Bourquard N, Hama S, Navab M, Grijalva VR, Morvardi S, Clarke CF, Vergnes L, Reue K, Teiber JF, Reddy ST. Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis. Antioxidants & Redox Signaling. 14: 341-51. PMID 20578959 DOI: 10.1089/Ars.2010.3430 |
0.428 |
|
| 2010 |
Marbois B, Xie LX, Choi S, Hirano K, Hyman K, Clarke CF. para-Aminobenzoic acid is a precursor in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 285: 27827-38. PMID 20592037 DOI: 10.1074/Jbc.M110.151894 |
0.587 |
|
| 2010 |
Brajcich BC, Iarocci AL, Johnstone LA, Morgan RK, Lonjers ZT, Hotchko MJ, Muhs JD, Kieffer A, Reynolds BJ, Mandel SM, Marbois BN, Clarke CF, Shepherd JN. Evidence that ubiquinone is a required intermediate for rhodoquinone biosynthesis in Rhodospirillum rubrum. Journal of Bacteriology. 192: 436-45. PMID 19933361 DOI: 10.1128/Jb.01040-09 |
0.473 |
|
| 2009 |
Lomenick B, Hao R, Jonai N, Chin RM, Aghajan M, Warburton S, Wang J, Wu RP, Gomez F, Loo JA, Wohlschlegel JA, Vondriska TM, Pelletier J, Herschman HR, Clardy J, ... Clarke CF, et al. Target identification using drug affinity responsive target stability (DARTS). Proceedings of the National Academy of Sciences of the United States of America. 106: 21984-9. PMID 19995983 DOI: 10.1073/Pnas.0910040106 |
0.53 |
|
| 2009 |
Cristina D, Cary M, Lunceford A, Clarke C, Kenyon C. A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans. Plos Genetics. 5: e1000450. PMID 19360127 DOI: 10.1371/Journal.Pgen.1000450 |
0.811 |
|
| 2009 |
Padilla-López S, Jiménez-Hidalgo M, Martín-Montalvo A, Clarke CF, Navas P, Santos-Ocaña C. Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae. Biochimica Et Biophysica Acta. 1788: 1238-48. PMID 19345667 DOI: 10.1016/J.Bbamem.2009.03.018 |
0.616 |
|
| 2009 |
Marbois B, Gin P, Gulmezian M, Clarke CF. The yeast Coq4 polypeptide organizes a mitochondrial protein complex essential for coenzyme Q biosynthesis. Biochimica Et Biophysica Acta. 1791: 69-75. PMID 19022396 DOI: 10.1016/J.Bbalip.2008.10.006 |
0.859 |
|
| 2009 |
Padilla S, Tran UC, Jiménez-Hidalgo M, López-Martín JM, Martín-Montalvo A, Clarke CF, Navas P, Santos-Ocaña C. Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis. Cellular and Molecular Life Sciences : Cmls. 66: 173-86. PMID 19002377 DOI: 10.1007/S00018-008-8547-7 |
0.87 |
|
| 2008 |
Saiki R, Lunceford AL, Shi Y, Marbois B, King R, Pachuski J, Kawamukai M, Gasser DL, Clarke CF. Coenzyme Q10 supplementation rescues renal disease in Pdss2kd/kd mice with mutations in prenyl diphosphate synthase subunit 2. American Journal of Physiology. Renal Physiology. 295: F1535-44. PMID 18784258 DOI: 10.1152/Ajprenal.90445.2008 |
0.845 |
|
| 2008 |
Do TQ, Moshkani S, Castillo P, Anunta S, Pogosyan A, Cheung A, Marbois B, Faull KF, Ernst W, Chiang SM, Fujii G, Clarke CF, Foster K, Porter E. Lipids including cholesteryl linoleate and cholesteryl arachidonate contribute to the inherent antibacterial activity of human nasal fluid. Journal of Immunology (Baltimore, Md. : 1950). 181: 4177-87. PMID 18768875 DOI: 10.4049/Jimmunol.181.6.4177 |
0.758 |
|
| 2008 |
Peng M, Falk MJ, Haase VH, King R, Polyak E, Selak M, Yudkoff M, Hancock WW, Meade R, Saiki R, Lunceford AL, Clarke CF, Gasser DL. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. Plos Genetics. 4: e1000061. PMID 18437205 DOI: 10.1371/Journal.Pgen.1000061 |
0.803 |
|
| 2008 |
Kiebish MA, Han X, Cheng H, Lunceford A, Clarke CF, Moon H, Chuang JH, Seyfried TN. Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria. Journal of Neurochemistry. 106: 299-312. PMID 18373617 DOI: 10.1111/J.1471-4159.2008.05383.X |
0.809 |
|
| 2008 |
Saiki R, Lunceford AL, Bixler T, Dang P, Lee W, Furukawa S, Larsen PL, Clarke CF. Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q. Aging Cell. 7: 291-304. PMID 18267002 DOI: 10.1111/J.1474-9726.2008.00378.X |
0.846 |
|
| 2007 |
Gulmezian M, Hyman KR, Marbois BN, Clarke CF, Javor GT. The role of UbiX in Escherichia coli coenzyme Q biosynthesis. Archives of Biochemistry and Biophysics. 467: 144-53. PMID 17889824 DOI: 10.1016/J.Abb.2007.08.009 |
0.849 |
|
| 2007 |
Tran UC, Clarke CF. Endogenous synthesis of coenzyme Q in eukaryotes. Mitochondrion. 7: S62-71. PMID 17482885 DOI: 10.1016/J.Mito.2007.03.007 |
0.869 |
|
| 2007 |
Hsieh EJ, Gin P, Gulmezian M, Tran UC, Saiki R, Marbois BN, Clarke CF. Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex. Archives of Biochemistry and Biophysics. 463: 19-26. PMID 17391640 DOI: 10.1016/J.Abb.2007.02.016 |
0.824 |
|
| 2006 |
Gulmezian M, Zhang H, Javor GT, Clarke CF. Genetic evidence for an interaction of the UbiG O-methyltransferase with UbiX in Escherichia coli coenzyme Q biosynthesis. Journal of Bacteriology. 188: 6435-9. PMID 16923914 DOI: 10.1128/Jb.00668-06 |
0.836 |
|
| 2006 |
Tran UC, Marbois B, Gin P, Gulmezian M, Jonassen T, Clarke CF. Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis. The Journal of Biological Chemistry. 281: 16401-9. PMID 16624818 DOI: 10.1074/Jbc.M513267200 |
0.839 |
|
| 2005 |
Barros MH, Johnson A, Gin P, Marbois BN, Clarke CF, Tzagoloff A. The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration. The Journal of Biological Chemistry. 280: 42627-35. PMID 16230336 DOI: 10.1074/Jbc.M510768200 |
0.84 |
|
| 2005 |
Johnson A, Gin P, Marbois BN, Hsieh EJ, Wu M, Barros MH, Clarke CF, Tzagoloff A. COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 280: 31397-404. PMID 16027161 DOI: 10.1074/Jbc.M503277200 |
0.865 |
|
| 2005 |
Marbois B, Gin P, Faull KF, Poon WW, Lee PT, Strahan J, Shepherd JN, Clarke CF. Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q. The Journal of Biological Chemistry. 280: 20231-8. PMID 15792955 DOI: 10.1074/Jbc.M501315200 |
0.852 |
|
| 2005 |
Gin P, Clarke CF. Genetic evidence for a multi-subunit complex in coenzyme Q biosynthesis in yeast and the role of the Coq1 hexaprenyl diphosphate synthase. The Journal of Biological Chemistry. 280: 2676-81. PMID 15548532 DOI: 10.1074/Jbc.M411527200 |
0.843 |
|
| 2004 |
Dyall SD, Yan W, Delgadillo-Correa MG, Lunceford A, Loo JA, Clarke CF, Johnson PJ. Non-mitochondrial complex I proteins in a hydrogenosomal oxidoreductase complex. Nature. 431: 1103-7. PMID 15510149 DOI: 10.1038/Nature02990 |
0.805 |
|
| 2004 |
Padilla S, Jonassen T, Jiménez-Hidalgo MA, Fernández-Ayala DJ, López-Lluch G, Marbois B, Navas P, Clarke CF, Santos-Ocaña C. Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity. The Journal of Biological Chemistry. 279: 25995-6004. PMID 15078893 DOI: 10.1074/Jbc.M400001200 |
0.844 |
|
| 2004 |
Hsieh EJ, Dinoso JB, Clarke CF. A tRNA(TRP) gene mediates the suppression of cbs2-223 previously attributed to ABC1/COQ8. Biochemical and Biophysical Research Communications. 317: 648-53. PMID 15063807 DOI: 10.1016/J.Bbrc.2004.03.096 |
0.839 |
|
| 2004 |
Baba SW, Belogrudov GI, Lee JC, Lee PT, Strahan J, Shepherd JN, Clarke CF. Yeast Coq5 C-methyltransferase is required for stability of other polypeptides involved in coenzyme Q biosynthesis. The Journal of Biological Chemistry. 279: 10052-9. PMID 14701817 DOI: 10.1074/Jbc.M313712200 |
0.61 |
|
| 2004 |
Esteves TC, Echtay KS, Jonassen T, Clarke CF, Brand MD. Ubiquinone is not required for proton conductance by uncoupling protein 1 in yeast mitochondria. The Biochemical Journal. 379: 309-15. PMID 14680474 DOI: 10.1042/Bj20031682 |
0.862 |
|
| 2003 |
Jonassen T, Davis DE, Larsen PL, Clarke CF. Reproductive fitness and quinone content of Caenorhabditis elegans clk-1 mutants fed coenzyme Q isoforms of varying length. The Journal of Biological Chemistry. 278: 51735-42. PMID 14530273 DOI: 10.1074/Jbc.M308760200 |
0.854 |
|
| 2003 |
Gin P, Hsu AY, Rothman SC, Jonassen T, Lee PT, Tzagoloff A, Clarke CF. The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis. The Journal of Biological Chemistry. 278: 25308-16. PMID 12721307 DOI: 10.1074/Jbc.M303234200 |
0.872 |
|
| 2002 |
Jonassen T, Marbois BN, Faull KF, Clarke CF, Larsen PL. Development and fertility in Caenorhabditis elegans clk-1 mutants depend upon transport of dietary coenzyme Q8 to mitochondria. The Journal of Biological Chemistry. 277: 45020-7. PMID 12324451 DOI: 10.1074/Jbc.M204758200 |
0.842 |
|
| 2002 |
Santos-Ocaña C, Do TQ, Padilla S, Navas P, Clarke CF. Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants. The Journal of Biological Chemistry. 277: 10973-81. PMID 11788608 DOI: 10.1074/Jbc.M112222200 |
0.865 |
|
| 2002 |
Larsen PL, Clarke CF. Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q. Science (New York, N.Y.). 295: 120-3. PMID 11778046 DOI: 10.1126/Science.1064653 |
0.552 |
|
| 2001 |
Belogrudov GI, Lee PT, Jonassen T, Hsu AY, Gin P, Clarke CF. Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q synthesis. Archives of Biochemistry and Biophysics. 392: 48-58. PMID 11469793 DOI: 10.1006/Abbi.2001.2448 |
0.872 |
|
| 2001 |
Do TQ, Hsu AY, Jonassen T, Lee PT, Clarke CF. A defect in coenzyme Q biosynthesis is responsible for the respiratory deficiency in Saccharomyces cerevisiae abc1 mutants. The Journal of Biological Chemistry. 276: 18161-8. PMID 11279158 DOI: 10.1074/Jbc.M100952200 |
0.862 |
|
| 2001 |
Jonassen T, Larsen PL, Clarke CF. A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants. Proceedings of the National Academy of Sciences of the United States of America. 98: 421-6. PMID 11136229 DOI: 10.1073/Pnas.98.2.421 |
0.868 |
|
| 2000 |
Poon WW, Davis DE, Ha HT, Jonassen T, Rather PN, Clarke CF. Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis. Journal of Bacteriology. 182: 5139-46. PMID 10960098 DOI: 10.1128/Jb.182.18.5139-5146.2000 |
0.808 |
|
| 2000 |
Jonassen T, Clarke CF. Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis. The Journal of Biological Chemistry. 275: 12381-7. PMID 10777520 DOI: 10.1074/Jbc.275.17.12381 |
0.837 |
|
| 2000 |
Hsu AY, Do TQ, Lee PT, Clarke CF. Genetic evidence for a multi-subunit complex in the O-methyltransferase steps of coenzyme Q biosynthesis. Biochimica Et Biophysica Acta. 1484: 287-97. PMID 10760477 DOI: 10.1016/S1388-1981(00)00019-6 |
0.843 |
|
| 2000 |
Clarke CF. New advances in coenzyme Q biosynthesis Protoplasma. 213: 134-147. DOI: 10.1007/BF01282151 |
0.398 |
|
| 1999 |
Vajo Z, King LM, Jonassen T, Wilkin DJ, Ho N, Munnich A, Clarke CF, Francomano CA. Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 10: 1000-4. PMID 10501970 DOI: 10.1007/S003359901147 |
0.805 |
|
| 1999 |
Poon WW, Barkovich RJ, Hsu AY, Frankel A, Lee PT, Shepherd JN, Myles DC, Clarke CF. Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis. The Journal of Biological Chemistry. 274: 21665-72. PMID 10419476 DOI: 10.1074/Jbc.274.31.21665 |
0.773 |
|
| 1999 |
Schultz JR, Clarke CF. Characterization of Saccharomyces cerevisiae ubiquinone-deficient mutants. Biofactors (Oxford, England). 9: 121-9. PMID 10416023 |
0.487 |
|
| 1998 |
Santos-Ocaña C, Villalba JM, Córdoba F, Padilla S, Crane FL, Clarke CF, Navas P. Genetic evidence for coenzyme Q requirement in plasma membrane electron transport. Journal of Bioenergetics and Biomembranes. 30: 465-75. PMID 9932649 DOI: 10.1023/A:1020542230308 |
0.405 |
|
| 1998 |
Santos-Ocaña C, Córdoba F, Crane FL, Clarke CF, Navas P. Coenzyme Q6 and iron reduction are responsible for the extracellular ascorbate stabilization at the plasma membrane of Saccharomyces cerevisiae. The Journal of Biological Chemistry. 273: 8099-105. PMID 9525912 DOI: 10.1074/Jbc.273.14.8099 |
0.413 |
|
| 1998 |
Jonassen T, Proft M, Randez-Gil F, Schultz JR, Marbois BN, Entian KD, Clarke CF. Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis. The Journal of Biological Chemistry. 273: 3351-7. PMID 9452453 DOI: 10.1074/Jbc.273.6.3351 |
0.823 |
|
| 1997 |
Poon WW, Do TQ, Marbois BN, Clarke CF. Sensitivity to treatment with polyunsaturated fatty acids is a general characteristic of the ubiquinone-deficient yeast coq mutants. Molecular Aspects of Medicine. 18: S121-7. PMID 9266513 DOI: 10.1016/S0098-2997(97)00004-6 |
0.862 |
|
| 1997 |
Barkovich RJ, Shtanko A, Shepherd JA, Lee PT, Myles DC, Tzagoloff A, Clarke CF. Characterization of the COQ5 gene from Saccharomyces cerevisiae: Evidence for a C-methyltransferase in ubiquinone biosynthesis Journal of Biological Chemistry. 272: 9182-9188. PMID 9083049 DOI: 10.1074/Jbc.272.14.9182 |
0.593 |
|
| 1997 |
Lee PT, Hsu AY, Ha HT, Clarke CF. A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene. Journal of Bacteriology. 179: 1748-54. PMID 9045837 DOI: 10.1128/Jb.179.5.1748-1754.1997 |
0.437 |
|
| 1996 |
Do TQ, Schultz JR, Clarke CF. Enhanced sensitivity of ubiquinone-deficient mutants of Saccharomyces cerevisiae to products of autoxidized polyunsaturated fatty acids. Proceedings of the National Academy of Sciences of the United States of America. 93: 7534-9. PMID 8755509 DOI: 10.1073/pnas.93.15.7534 |
0.835 |
|
| 1996 |
Hsu AY, Poon WW, Shepherd JA, Myles DC, Clarke CF. Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis. Biochemistry. 35: 9797-806. PMID 8703953 DOI: 10.1021/Bi9602932 |
0.677 |
|
| 1996 |
Jonassen T, Marbois BN, Kim L, Chin A, Xia YR, Lusis AJ, Clarke CF. Isolation and sequencing of the rat Coq7 gene and the mapping of mouse Coq7 to chromosome 7. Archives of Biochemistry and Biophysics. 330: 285-9. PMID 8660658 DOI: 10.1006/Abbi.1996.0255 |
0.792 |
|
| 1996 |
Schultz JR, Ellerby LM, Gralla EB, Valentine JS, Clarke CF. Autoxidation of ubiquinol-6 is independent of superoxide dismutase. Biochemistry. 35: 6595-603. PMID 8639607 DOI: 10.1021/Bi960245H |
0.332 |
|
| 1996 |
Marbois BN, Clarke CF. The COQ7 gene encodes a protein in saccharomyces cerevisiae necessary for ubiquinone biosynthesis. The Journal of Biological Chemistry. 271: 2995-3004. PMID 8621692 DOI: 10.1074/Jbc.271.6.2995 |
0.545 |
|
| 1996 |
Shepherd JA, Poon WW, Myles DC, Clarke CF. The biosynthesis of ubiquinone: Synthesis and enzymatic modification of biosynthetic precursors Tetrahedron Letters. 37: 2395-2398. DOI: 10.1016/0040-4039(96)00324-3 |
0.685 |
|
| 1996 |
Jonassen T, Marbois B, Kim L, Chin A, Xia Y, Lusis AJ, Clarke CF. Isolation and Sequencing of the RatCoq7Gene and the Mapping of MouseCoq7to Chromosome 7 Archives of Biochemistry and Biophysics. 335: 227. DOI: 10.1006/Abbi.1996.0502 |
0.753 |
|
| 1995 |
Poon WW, Marbois BN, Faull KF, Clarke CF. 3-Hexaprenyl-4-hydroxybenzoic acid forms a predominant intermediate pool in ubiquinone biosynthesis in Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics. 320: 305-14. PMID 7625838 DOI: 10.1016/0003-9861(95)90014-4 |
0.671 |
|
| 1994 |
Marbois BN, Hsu A, Pillai R, Colicelli J, Clarke CF. Cloning of a rat cDNA encoding dihydroxypolyprenylbenzoate methyltransferase by functional complementation of a Saccharomyces cerevisiae mutant deficient in ubiquinone biosynthesis. Gene. 138: 213-7. PMID 8125303 DOI: 10.1016/0378-1119(94)90810-9 |
0.45 |
|
| 1994 |
Marbois BN, Xia YR, Lusis AJ, Clarke CF. Ubiquinone biosynthesis in eukaryotic cells: tissue distribution of mRNA encoding 3,4-dihydroxy-5-polyprenylbenzoate methyltransferase in the rat and mapping of the COQ3 gene to mouse chromosome 4. Archives of Biochemistry and Biophysics. 313: 83-8. PMID 8053692 DOI: 10.1006/Abbi.1994.1362 |
0.449 |
|
| 1991 |
Teruya JH, Salido EC, Edwards PA, Clarke CF. Testis-specific transcripts of rat farnesyl pyrophosphate synthetase are developmentally regulated and localized to haploid germ cells. Biology of Reproduction. 44: 663-71. PMID 2043737 DOI: 10.1095/Biolreprod44.4.663 |
0.536 |
|
| 1991 |
Clarke CF, Williams W, Teruya JH. Ubiquinone biosynthesis in Saccharomyces cerevisiae. Isolation and sequence of COQ3, the 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase gene. The Journal of Biological Chemistry. 266: 16636-44. PMID 1885593 |
0.472 |
|
| 1990 |
Teruya JH, Kutsunai SY, Spear DH, Edwards PA, Clarke CF. Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA. Molecular and Cellular Biology. 10: 2315-26. PMID 2325654 DOI: 10.1128/mcb.10.5.2315-2326.1990 |
0.546 |
|
| 1989 |
Heinzmann C, Clarke CF, Klisak I, Mohandas T, Sparkes RS, Edwards PA, Lusis AJ. Dispersed family of human genes with sequence similarity to farnesyl pyrophosphate synthetase. Genomics. 5: 493-500. PMID 2613235 DOI: 10.1016/0888-7543(89)90015-3 |
0.513 |
|
| 1987 |
Clarke CF, Tanaka RD, Svenson K, Wamsley M, Fogelman AM, Edwards PA. Molecular cloning and sequence of a cholesterol-repressible enzyme related to prenyltransferase in the isoprene biosynthetic pathway. Molecular and Cellular Biology. 7: 3138-46. PMID 3670308 DOI: 10.1128/mcb.7.9.3138-3146.1987 |
0.558 |
|
| 1987 |
Clarke CF, Edwards PA, Fogelman AM. Chapter 8 Cellular regulation of cholesterol metabolism New Comprehensive Biochemistry. 14: 261-276. DOI: 10.1016/S0167-7306(08)60202-1 |
0.57 |
|
| 1985 |
Clarke CF, Fogelman AM, Edwards PA. Transcriptional regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in rat liver. The Journal of Biological Chemistry. 260: 14363-7. PMID 3850901 |
0.495 |
|
| 1984 |
Clarke CF, Fogelman AM, Edwards PA. Diurnal rhythm of rat liver mRNAs encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase. Correlation of functional and total mRNA levels with enzyme activity and protein. The Journal of Biological Chemistry. 259: 10439-47. PMID 6540773 |
0.494 |
|
| 1983 |
Clarke CF, Edwards PA, Lan SF, Tanaka RD, Fogelman AM. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels in rat liver. Proceedings of the National Academy of Sciences of the United States of America. 80: 3305-8. PMID 6190175 DOI: 10.1073/Pnas.80.11.3305 |
0.546 |
|
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