Andrew Koff

Affiliations: 
Molecular Biology Weill Cornell Medical College, New York, NY, United States 
Area:
Biochemistry, Molecular Biology, Cell Biology
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"Andrew Koff"
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Publications

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Li Q, Jiang B, Guo J, et al. (2021) INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors. Cancer Discovery
Dickson MA, Koff A, D'Angelo SP, et al. (2019) Phase 2 study of the CDK4 inhibitor abemaciclib in dedifferentiated liposarcoma. Journal of Clinical Oncology. 37: 11004-11004
Klein ME, Dickson MA, Antonescu C, et al. (2018) PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6 inhibitor therapy-induced senescence. Oncogene
Klein ME, Kovatcheva M, Davis LE, et al. (2018) CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought. Cancer Cell
Kovatcheva M, Klein ME, Tap WD, et al. (2018) Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors. Molecular & Cellular Oncology. 5: e1384882
Kovatcheva M, Liao W, Klein ME, et al. (2017) ATRX is a regulator of therapy induced senescence in human cells. Nature Communications. 8: 386
Dickson MA, Schwartz GK, Keohan ML, et al. (2016) Progression-Free Survival Among Patients With Well-Differentiated or Dedifferentiated Liposarcoma Treated With CDK4 Inhibitor Palbociclib: A Phase 2 Clinical Trial. Jama Oncology
Kovatcheva M, Liu DD, Dickson MA, et al. (2015) MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. Oncotarget. 6: 8226-43
Raheja R, Liu Y, Hukkelhoven E, et al. (2014) The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity. The Biochemical Journal. 458: 537-45
Liu Y, Raheja R, Yeh N, et al. (2014) TRIM3, a tumor suppressor linked to regulation of p21 Waf1/Cip1 Oncogene. 33: 308-315
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