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Peter G. Schultz - Publications

Affiliations: 
1985-1999 University of California, Berkeley, Berkeley, CA, United States 
 1999- Scripps Research Institute 
Website:
http://schultz.scripps.edu/schultz.php
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Year Citation  Score
2024 Pigula M, Lai YC, Koh M, Diercks CS, Rogers TF, Dik DA, Schultz PG. An unnatural amino acid dependent, conditional Pseudomonas vaccine prevents bacterial infection. Nature Communications. 15: 6766. PMID 39117651 DOI: 10.1038/s41467-024-50843-7  0.624
2024 Gupta AK, Pedroarena J, Nazarian A, Antonova-Koch J, Weiss F, Kumpornsin K, Chi V, Woods AK, Lee KJ, Joseph SB, Li S, Brittain J, De Hostos E, Duffy J, Cooper A, ... Schultz PG, et al. Identification of mCMQ069, a novel antimalarial with potential for a single-dose cure and/or 28-day chemoprevention. Biorxiv : the Preprint Server For Biology. PMID 39005341 DOI: 10.1101/2024.07.01.601566  0.77
2024 Gupta AK, Eliasen AM, Andahazy W, Zhou F, Henson K, Chi V, Woods AK, Joseph SB, Kuhen KL, Wisler J, Ramachandruni H, Duffy J, Burrows JN, Vadas E, Slade A, ... Schultz PG, et al. A Prodrug Strategy to Reposition Atovaquone as a Long-Acting Injectable for Malaria Chemoprotection. Biorxiv : the Preprint Server For Biology. PMID 38979188 DOI: 10.1101/2024.02.08.579395  0.781
2024 Shim HS, Iaconelli J, Shang X, Li J, Lan ZD, Jiang S, Nutsch K, Beyer BB, Lairson LL, Boutin AT, Bollong MJ, Schultz PG, DePinho RA. TERT activation targets DNA methylation and multiple aging hallmarks. Cell. PMID 38908367 DOI: 10.1016/j.cell.2024.05.048  0.778
2024 Riva L, Yuan S, Yin X, Martin-Sancho L, Matsunaga N, Pache L, Burgstaller-Muehlbacher S, De Jesus PD, Teriete P, Hull MV, Chang MW, Chan JF, Cao J, Poon VK, Herbert KM, ... ... Schultz PG, et al. Author Correction: Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. Nature. PMID 38890463 DOI: 10.1038/s41586-024-07659-8  0.764
2024 Elshan NGRD, Wolff KC, Riva L, Woods AK, Grabovyi G, Wilson K, Pedroarena J, Ghorai S, Nazarian A, Weiss F, Liu Y, Mazumdar W, Song L, Okwor N, Malvin J, ... ... Schultz PG, et al. Correction to "Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead". Journal of Medicinal Chemistry. PMID 38875353 DOI: 10.1021/acs.jmedchem.4c01269  0.775
2024 Shao S, Zhang N, Specht GP, You S, Song L, Fu Q, Huang D, You H, Shu J, Domissy A, Li S, Nguyen-Tran V, Joseph SB, Chatterjee AK, Chen JJ, ... Schultz PG, et al. Pharmacological expansion of type 2 alveolar epithelial cells promotes regenerative lower airway repair. Proceedings of the National Academy of Sciences of the United States of America. 121: e2400077121. PMID 38598345 DOI: 10.1073/pnas.2400077121  0.78
2024 Dayan Elshan NGR, Wolff KC, Riva L, Woods AK, Grabovyi G, Wilson K, Pedroarena J, Ghorai S, Nazarian A, Weiss F, Liu Y, Mazumdar W, Song L, Okwor N, Malvin J, ... ... Schultz PG, et al. Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead. Journal of Medicinal Chemistry. PMID 38335279 DOI: 10.1021/acs.jmedchem.3c01938  0.783
2023 Grzelak EM, Elshan NGRD, Shao S, Bulos ML, Joseph SB, Chatterjee AK, Chen JJ, Nguyên-Trân V, Schultz PG, Bollong MJ. Pharmacological YAP activation promotes regenerative repair of cutaneous wounds. Proceedings of the National Academy of Sciences of the United States of America. 120: e2305085120. PMID 37399395 DOI: 10.1073/pnas.2305085120  0.779
2023 Ko Y, Hong M, Lee S, Kumar M, Ibrahim L, Nutsch K, Stanton C, Sondermann P, Sandoval B, Bulos ML, Iaconelli J, Chatterjee AK, Wiseman RL, Schultz PG, Bollong MJ. S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling. Proceedings of the National Academy of Sciences of the United States of America. 120: e2300763120. PMID 37155889 DOI: 10.1073/pnas.2300763120  0.792
2022 Martínez-Peña F, Pearson AD, Tang EL, Kuburich NA, Mani SA, Schultz PG, Bollong MJ, Lairson LL. Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers. European Journal of Medicinal Chemistry. 242: 114638. PMID 36001933 DOI: 10.1016/j.ejmech.2022.114638  0.796
2022 Wilburn KM, Montague CR, Qin B, Woods AK, Love MS, McNamara CW, Schultz PG, Southard TL, Huang L, Petrassi HM, VanderVen BC. Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis. Plos Pathogens. 18: e1009862. PMID 35134095 DOI: 10.1371/journal.ppat.1009862  0.781
2021 Lee SC, Ma JSY, Kim MS, Laborda E, Choi SH, Hampton EN, Yun H, Nunez V, Muldong MT, Wu CN, Ma W, Kulidjian AA, Kane CJ, Klyushnichenko V, Woods AK, ... ... Schultz PG, et al. A PSMA-targeted bispecific antibody for prostate cancer driven by a small-molecule targeting ligand. Science Advances. 7. PMID 34380625 DOI: 10.1126/sciadv.abi8193  0.792
2021 Bakowski MA, Beutler N, Wolff KC, Kirkpatrick MG, Chen E, Nguyen TH, Riva L, Shaabani N, Parren M, Ricketts J, Gupta AK, Pan K, Kuo P, Fuller M, Garcia E, ... ... Schultz PG, et al. Drug repurposing screens identify chemical entities for the development of COVID-19 interventions. Nature Communications. 12: 3309. PMID 34083527 DOI: 10.1038/s41467-021-23328-0  0.791
2021 Shalhout SZ, Yang PY, Grzelak EM, Nutsch K, Shao S, Zambaldo C, Iaconelli J, Ibrahim L, Stanton C, Chadwick SR, Chen E, DeRan M, Li S, Hull M, Wu X, ... ... Schultz PG, et al. YAP-dependent proliferation by a small molecule targeting annexin A2. Nature Chemical Biology. PMID 33723431 DOI: 10.1038/s41589-021-00755-0  0.795
2021 Jo J, Ibrahim L, Iaconelli J, Kwak J, Kumar M, Jung Y, Lairson LL, Chatterjee AK, Schultz PG, Bollong MJ, Yun H. Discovery and SAR studies of 3-amino-4-(phenylsulfonyl)tetrahydrothiophene 1,1-dioxides as non-electrophilic antioxidant response element (ARE) activators. Bioorganic Chemistry. 108: 104614. PMID 33508678 DOI: 10.1016/j.bioorg.2020.104614  0.788
2021 Koh M, Ahmad I, Ko Y, Zhang Y, Martinez TF, Diedrich JK, Chu Q, Moresco JJ, Erb MA, Saghatelian A, Schultz PG, Bollong MJ. A short ORF-encoded transcriptional regulator. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33468658 DOI: 10.1073/pnas.2021943118  0.803
2020 Zambaldo C, Koh M, Nasertorabi F, Han GW, Chatterjee A, Stevens RC, Schultz PG. An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli. Bioorganic & Medicinal Chemistry. 28: 115662. PMID 33069069 DOI: 10.1016/J.Bmc.2020.115662  0.796
2020 Li JC, Nasertorabi F, Xuan W, Han GW, Stevens RC, Schultz PG. A Single Reactive Noncanonical Amino Acid is Able to Dramatically Stabilize Protein Structure. Acs Chemical Biology. PMID 33006884 DOI: 10.1021/acschembio.0c00196  0.799
2020 Lear S, Pflimlin E, Zhou Z, Huang D, Weng S, Nguyen-Tran V, Joseph SB, Roller S, Peterson S, Li J, Tremblay M, Schultz PG, Shen W. Engineering of a Potent, Long-Acting NPY2R Agonist for Combination with a GLP-1R Agonist as a Multi-Hormonal Treatment for Obesity. Journal of Medicinal Chemistry. PMID 32844654 DOI: 10.1021/Acs.Jmedchem.0C00740  0.774
2020 Chin EN, Yu C, Vartabedian VF, Jia Y, Kumar M, Gamo AM, Vernier W, Ali SH, Kissai M, Lazar DC, Nguyen N, Pereira LE, Benish B, Woods AK, Joseph SB, ... ... Schultz PG, et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science (New York, N.Y.). 369: 993-999. PMID 32820126 DOI: 10.1126/Science.Abb4255  0.79
2020 Riva L, Yuan S, Yin X, Martin-Sancho L, Matsunaga N, Pache L, Burgstaller-Muehlbacher S, De Jesus PD, Teriete P, Hull MV, Chang MW, Chan JF, Cao J, Poon VK, Herbert KM, ... ... Schultz PG, et al. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. Nature. PMID 32707573 DOI: 10.1038/S41586-020-2577-1  0.786
2020 Riva L, Yuan S, Yin X, Martin-Sancho L, Matsunaga N, Burgstaller-Muehlbacher S, Pache L, De Jesus PP, Hull MV, Chang M, Chan JF, Cao J, Poon VK, Herbert K, Nguyen TT, ... ... Schultz PG, et al. A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals. Biorxiv : the Preprint Server For Biology. PMID 32511357 DOI: 10.1101/2020.04.16.044016  0.781
2020 Zambaldo C, Vinogradova EV, Qi X, Iaconelli J, Suciu RM, Koh M, Senkane K, Chadwick SR, Sanchez BB, Chen JS, Chatterjee AK, Liu P, Schultz PG, Cravatt BF, Bollong MJ. 2-Sulfonyl pyridines as tunable, cysteine-reactive electrophiles. Journal of the American Chemical Society. PMID 32302104 DOI: 10.1021/Jacs.0C02721  0.804
2020 Shao S, Koh M, Schultz PG. Expanding the genetic code of the human hematopoietic system. Proceedings of the National Academy of Sciences of the United States of America. PMID 32253306 DOI: 10.1073/Pnas.1914408117  0.675
2020 Yang PY, Zou H, Amso Z, Lee C, Huang D, Woods AK, Nguyen-Tran VTB, Schultz PG, Shen W. New Generation Oxyntomodulin Peptides with Improved Pharmacokinetic Profiles Exhibit Weight Reducing and Anti-Steatotic Properties in Mice. Bioconjugate Chemistry. PMID 32243137 DOI: 10.1021/Acs.Bioconjchem.0C00093  0.771
2020 Johnson K, Woods A, Joseph S, Chatterjee A, Zhu S, Wisler J, Klyushnichenko V, Li J, Lotz M, Tremblay M, Schultz P. Development of KA34 as a cartilage regenerative therapy for Osteoarthritis Osteoarthritis and Cartilage. 28: S518. DOI: 10.1016/J.Joca.2020.02.814  0.758
2019 Ardestani A, Li S, Annamalai K, Lupse B, Geravandi S, Dobrowolski A, Yu S, Zhu S, Baguley TD, Surakattula M, Oetjen J, Hauberg-Lotte L, Herranz R, Awal S, Altenhofen D, ... ... Schultz PG, et al. Neratinib protects pancreatic beta cells in diabetes. Nature Communications. 10: 5015. PMID 31676778 DOI: 10.1038/S41467-019-12880-5  0.776
2019 Iaconelli J, Chen E, Hull M, Schultz PG, Bollong M. Small molecule stimulators of NRF1 transcriptional activity. Chembiochem : a European Journal of Chemical Biology. PMID 31596542 DOI: 10.1002/Cbic.201900487  0.704
2019 Koh M, Yao A, Gleason PR, Mills JH, Schultz PG. A general strategy for engineering noncanonical amino acid dependent bacterial growth. Journal of the American Chemical Society. PMID 31580059 DOI: 10.1021/Jacs.9B08491  0.802
2019 Mehta AP, Ko Y, Supekova L, Pestonjamasp K, Li J, Schultz PG. Towards a synthetic yeast endosymbiont with a minimal genome. Journal of the American Chemical Society. PMID 31419116 DOI: 10.1021/Jacs.9B08290  0.781
2019 Zhang Y, Fang C, Wang RE, Wang Y, Guo H, Guo C, Zhao L, Li S, Li X, Schultz PG, Cao YJ, Wang F. A tumor-targeted immune checkpoint blocker. Proceedings of the National Academy of Sciences of the United States of America. PMID 31332018 DOI: 10.1073/Pnas.1905646116  0.791
2019 Koh M, Cho HY, Yu C, Choi S, Lee KB, Schultz PG. Site-specific Incorporation of a Dithiolane Containing Amino Acid into Proteins. Bioconjugate Chemistry. PMID 31319026 DOI: 10.1021/Acs.Bioconjchem.9B00413  0.806
2019 Li JC, Nastertorabi F, Xuan W, Han GW, Stevens RC, Schultz PG. A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure. Acs Chemical Biology. PMID 31181898 DOI: 10.1021/acschembio.9b00002  0.802
2019 Bakowski MA, Shiroodi RK, Liu R, Olejniczak J, Yang B, Gagaring K, Guo H, White PM, Chappell L, Debec A, Landmann F, Dubben B, Lenz F, Struever D, Ehrens A, ... ... Schultz PG, et al. Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections. Science Translational Medicine. 11. PMID 31068442 DOI: 10.1126/Scitranslmed.Aav3523  0.785
2019 Lucki NC, Villa GR, Vergani N, Bollong MJ, Beyer BA, Lee JW, Anglin JL, Spangenberg SH, Chin EN, Sharma A, Johnson K, Sander PN, Gordon P, Skirboll SL, Wurdak H, ... Schultz PG, et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 30846550 DOI: 10.1073/Pnas.1816626116  0.789
2018 Li JC, Liu T, Wang Y, Mehta AP, Schultz PG. Enhancing Protein Stability with Genetically Encoded Noncanonical Amino Acids. Journal of the American Chemical Society. PMID 30433771 DOI: 10.1021/Jacs.8B07157  0.804
2018 Ahmed N, De Graaf JF, Ahmed N, Foss DV, Delcorde J, Schultz PG, Pezacki JP. Visualization of the Delivery and Release of Small RNAs Using Genetic Code Expansion and Unnatural RNA-Binding Proteins. Bioconjugate Chemistry. PMID 30408949 DOI: 10.1021/Acs.Bioconjchem.8B00649  0.56
2018 Mehta AP, Supekova L, Chen JH, Pestonjamasp K, Webster P, Ko Y, Henderson SC, McDermott G, Supek F, Schultz PG. Engineering yeast endosymbionts as a step toward the evolution of mitochondria. Proceedings of the National Academy of Sciences of the United States of America. PMID 30373839 DOI: 10.1073/Pnas.1813143115  0.781
2018 Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. PMID 30323285 DOI: 10.1038/S41586-018-0622-0  0.791
2018 Janes J, Young ME, Chen E, Rogers NH, Burgstaller-Muehlbacher S, Hughes LD, Love MS, Hull MV, Kuhen KL, Woods AK, Joseph SB, Petrassi HM, McNamara CW, Tremblay MS, Su AI, ... Schultz PG, et al. The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis. Proceedings of the National Academy of Sciences of the United States of America. 115: 10750-10755. PMID 30282735 DOI: 10.1073/Pnas.1810137115  0.78
2018 Mehta AP, Wang Y, Reed SA, Supekova L, Javahishvili T, Chaput JC, Schultz PG. Bacterial Genome Containing Chimeric DNA-RNA Sequences. Journal of the American Chemical Society. PMID 30160955 DOI: 10.1021/Jacs.8B07046  0.772
2018 Abdeen S, Kunkle T, Salim N, Ray AM, Mammadova N, Summers C, Stevens M, Ambrose A, Park Y, Schultz PG, Horwich AL, Hoang Q, Chapman E, Johnson SM. Sulfonamido-2-arylbenzoxazole GroEL/ES inhibitors are potent antibacterials against methicillin-resistant Staphylococcus aureus (MRSA). Journal of Medicinal Chemistry. PMID 30060666 DOI: 10.1021/Acs.Jmedchem.8B00989  0.515
2018 Miglianico M, Eldering M, Slater H, Ferguson N, Ambrose P, Lees RS, Koolen KMJ, Pruzinova K, Jancarova M, Volf P, Koenraadt CJM, Duerr HP, Trevitt G, Yang B, Chatterjee AK, ... ... Schultz PG, et al. Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases. Proceedings of the National Academy of Sciences of the United States of America. PMID 29967151 DOI: 10.1073/Pnas.1801338115  0.759
2018 Zhong L, Tran T, Baguley TD, Lee SJ, Henke A, To A, Li S, Yu S, Grieco FA, Roland J, Schultz PG, Eizirik DL, Rogers N, Chartterjee AK, Tremblay MS, et al. A Novel Inhibitor of iNOS Dimerization Protects Against Cytokine-Induced Rat β-cell Dysfunction. British Journal of Pharmacology. PMID 29888783 DOI: 10.1111/Bph.14388  0.773
2018 Zhang G, Baidin V, Pahil KS, Moison E, Tomasek D, Ramadoss NS, Chatterjee AK, McNamara CW, Young TS, Schultz PG, Meredith TC, Kahne D. Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors. Proceedings of the National Academy of Sciences of the United States of America. PMID 29735709 DOI: 10.1073/Pnas.1804670115  0.778
2018 Crnovcic I, Gan F, Yang D, Dong LB, Schultz PG, Shen B. Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity. Bioorganic & Medicinal Chemistry Letters. PMID 29730026 DOI: 10.1016/J.Bmcl.2018.04.065  0.699
2018 Wang J, Schultz PG, Johnson KA. Mechanistic studies of a small-molecule modulator of SMN2 splicing. Proceedings of the National Academy of Sciences of the United States of America. PMID 29712837 DOI: 10.1073/Pnas.1800260115  0.685
2018 Supekova L, Zambaldo C, Choi S, Lim R, Luo X, Kazane SA, Young TS, Schultz PG. The genetic incorporation of p-azidomethyl-l-phenylalanine into proteins in yeast. Bioorganic & Medicinal Chemistry Letters. PMID 29625824 DOI: 10.1016/J.Bmcl.2018.03.055  0.795
2018 Yao A, Reed SA, Koh M, Yu C, Luo X, Mehta AP, Schultz PG. Progress toward a reduced phage genetic code. Bioorganic & Medicinal Chemistry. PMID 29609949 DOI: 10.1016/J.Bmc.2018.03.035  0.799
2018 Yang P, Zou H, Lee C, Muppidi A, Chao E, Fu Q, Luo X, Wang D, Schultz PG, Shen W. A Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate-Induced Mouse Colitis Models. Journal of Medicinal Chemistry. PMID 29528634 DOI: 10.1021/Acs.Jmedchem.7B00768  0.771
2018 Gan F, Liu R, Wang F, Schultz PG. Functional replacement of histidine in proteins to generate noncanonical amino acid dependent organisms. Journal of the American Chemical Society. PMID 29509426 DOI: 10.1021/Jacs.7B13452  0.805
2018 Sun SB, Sen S, Kim NJ, Magliery TJ, Schultz PG, Wang F. Retraction of "Mutational Analysis of 48G7 Reveals that Somatic Hypermutation Affects Both Antibody Stability and Binding Affinity". Journal of the American Chemical Society. PMID 29376652 DOI: 10.1021/Jacs.7B08106  0.781
2018 Xuan W, Collins D, Koh M, Shao S, Yao A, Xiao H, Garner PP, Schultz PG. Site-specific Incorporation of a Thioester Containing Amino Acid into Proteins. Acs Chemical Biology. PMID 29360343 DOI: 10.1021/Acschembio.7B00998  0.811
2018 Young DD, Schultz PG. Playing with the molecules of life. Acs Chemical Biology. PMID 29345901 DOI: 10.1021/Acschembio.7B00974  0.634
2017 Du J, Cao Y, Liu Y, Wang Y, Zhang Y, Fu G, Zhang Y, Lu L, Luo X, Kim CH, Schultz PG, Wang F. Engineering Bifunctional Antibodies with Constant Region Fusion Architectures. Journal of the American Chemical Society. PMID 29186655 DOI: 10.1021/Jacs.7B09641  0.8
2017 Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 29087350 DOI: 10.1073/Pnas.1716009114  0.793
2017 Laborda E, Mazagova M, Shao S, Wang X, Quirino H, Woods AK, Hampton EN, Rodgers DT, Kim CH, Schultz PG, Young TS. Development of A Chimeric Antigen Receptor Targeting C-Type Lectin-Like Molecule-1 for Human Acute Myeloid Leukemia. International Journal of Molecular Sciences. 18. PMID 29077054 DOI: 10.3390/Ijms18112259  0.786
2017 Choi SH, Mahankali M, Lee SJ, Hull M, Petrassi HM, Chatterjee AK, Schultz PG, Jones KA, Shen W. Targeted disruption of Myc-Max oncoprotein complex by a small molecule. Acs Chemical Biology. PMID 28976731 DOI: 10.1021/Acschembio.7B00799  0.803
2017 Xuan W, Yao A, Schultz PG. Genetically Encoded Fluorescent Probe for Detecting Sirtuins in Living Cells. Journal of the American Chemical Society. PMID 28857557 DOI: 10.1021/Jacs.7B05725  0.799
2017 Zambaldo C, Luo X, Mehta AP, Schultz PG. Recombinant Macrocyclic Lanthipeptides Incorporating Non-Canonical Amino Acids. Journal of the American Chemical Society. PMID 28809560 DOI: 10.1021/Jacs.7B04159  0.806
2017 Lee SJ, Mahankali M, Bitar A, Zou H, Chao E, Nguyen H, Gonzalez J, Caballero D, Hull M, Wang D, Schultz PG, Shen W. A Novel Role for RARα Agonists as Apolipoprotein CIII Inhibitors Identified from High Throughput Screening. Scientific Reports. 7: 5824. PMID 28724938 DOI: 10.1038/S41598-017-05163-W  0.779
2017 Luo X, Fu G, Wang RE, Zhu X, Zambaldo C, Liu R, Liu T, Lyu X, Du J, Xuan W, Yao A, Reed SA, Kang M, Zhang Y, Guo H, ... ... Schultz PG, et al. Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria. Nature Chemical Biology. PMID 28604693 DOI: 10.1038/Nchembio.2405  0.794
2017 Liu T, Jia P, Ma H, Reed SA, Luo X, Larman HB, Schultz PG. Construction and Screening of a Lentiviral Secretome Library. Cell Chemical Biology. PMID 28602759 DOI: 10.1016/J.Chembiol.2017.05.017  0.802
2017 Xuan W, Schultz PG. A New Strategy for Creating Noncanonical Amino Acid Dependent Organisms. Angewandte Chemie (International Ed. in English). PMID 28593724 DOI: 10.1002/Ange.201703553  0.67
2017 Bollong MJ, Yang B, Vergani N, Beyer BA, Chin EN, Zambaldo C, Wang D, Chatterjee AK, Lairson LL, Schultz PG. Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis. Proceedings of the National Academy of Sciences of the United States of America. 114: 4679-4684. PMID 28416697 DOI: 10.1073/Pnas.1702750114  0.78
2017 Koh M, Nasertorabi F, Han GW, Stevens RC, Schultz PG. Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid. Journal of the American Chemical Society. PMID 28413876 DOI: 10.1021/Jacs.7B02273  0.743
2017 Xuan W, Shao S, Schultz PG. Protein Crosslinking by Genetically Encoded Noncanonical Amino Acids with Reactive Aryl Carbamate Side Chains. Angewandte Chemie (International Ed. in English). PMID 28371162 DOI: 10.1002/Anie.201611841  0.665
2017 Bouvard C, Lim SM, Ludka J, Yazdani N, Woods AK, Chatterjee AK, Schultz PG, Zhu S. Small molecule selectively suppresses MYC transcription in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 114: 3497-3502. PMID 28292893 DOI: 10.1073/Pnas.1702663114  0.787
2017 Love MS, Beasley FC, Jumani RS, Wright TM, Chatterjee AK, Huston CD, Schultz PG, McNamara CW. A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis. Plos Neglected Tropical Diseases. 11: e0005373. PMID 28158186 DOI: 10.1371/Journal.Pntd.0005373  0.671
2017 Yu S, Pearson A, Lim R, Rodgers D, Li S, Parker H, Weglarz M, Hampton E, Bollong M, Shen J, Zumbaldo C, Wang D, Woods A, Wright T, Schultz P, et al. P-262 A PDE4 Inhibitor-antibody Conjugate for Treating Ulcerative Colitis Inflammatory Bowel Diseases. 23. DOI: 10.1097/01.Mib.0000512805.98510.C0  0.776
2017 Xuan W, Schultz PG. A Strategy for Creating Organisms Dependent on Noncanonical Amino Acids Angewandte Chemie. 129: 9298-9301. DOI: 10.1002/ange.201703553  0.594
2016 Zhang Z, English BP, Grimm JB, Kazane SA, Hu W, Tsai A, Inouye C, You C, Piehler J, Schultz PG, Lavis LD, Revyakin A, Tjian R. Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis. Genes & Development. 30: 2106-2118. PMID 27798851 DOI: 10.1101/Gad.285395.116  0.74
2016 Mehta AP, Li H, Reed SA, Supekova L, Javahishvili T, Schultz PG. Replacement of 2'-Deoxycytidine by 2'-Deoxycytidine Analogues in the E. coli Genome. Journal of the American Chemical Society. PMID 27762133 DOI: 10.1021/Jacs.6B09661  0.775
2016 Yu S, Pearson AD, Lim RK, Rodgers DT, Li S, Parker HB, Weglarz M, Hampton EN, Bollong MJ, Shen J, Zambaldo C, Wang D, Woods AK, Wright TM, Schultz PG, et al. Targeted delivery of an anti-inflammatory PDE4 inhibitor to immune cells via an antibody-drug conjugate. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 27731313 DOI: 10.1038/Mt.2016.175  0.788
2016 Abdeen S, Salim N, Mammadova N, Summers CM, Goldsmith-Pestana K, McMahon-Pratt D, Schultz PG, Horwich AL, Chapman E, Johnson SM. Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness. Bioorganic & Medicinal Chemistry Letters. PMID 27720295 DOI: 10.1016/J.Bmcl.2016.09.051  0.538
2016 Liu Y, Wang Y, Zhang Y, Liu T, Jia H, Zou H, Fu Q, Zhang Y, Lu L, Chao E, Parker H, Nguyen-Tran V, Shen W, Wang D, Schultz PG, et al. Rational Design of Dual Agonist-Antibody Fusions as Long-acting Therapeutic Hormones. Acs Chemical Biology. PMID 27704775 DOI: 10.1021/Acschembio.6B00630  0.793
2016 Wang RE, Wang Y, Zhang Y, Gabrelow C, Zhang Y, Chi V, Fu Q, Luo X, Wang D, Joseph S, Johnson K, Chatterjee AK, Wright TM, Nguyen-Tran VT, Teijaro J, ... ... Schultz PG, et al. Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant. Proceedings of the National Academy of Sciences of the United States of America. 113: 11501-11506. PMID 27663736 DOI: 10.1073/Pnas.1612803113  0.798
2016 Luo X, Wang TA, Zhang Y, Wang F, Schultz PG. Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator. Cell Chemical Biology. 23: 1098-1102. PMID 27662253 DOI: 10.1016/J.Chembiol.2016.08.007  0.754
2016 Wang Y, Du J, Zou H, Liu Y, Zhang Y, Gonzalez J, Chao E, Lu L, Yang P, Parker H, Nguyen-Tran V, Shen W, Wang D, Schultz PG, Wang F. Multifunctional Antibody Agonists Targeting Glucagon-like Peptide-1, Glucagon, and Glucose-Dependent Insulinotropic Polypeptide Receptors. Angewandte Chemie (International Ed. in English). PMID 27595986 DOI: 10.1002/Anie.201606321  0.781
2016 Xuan W, Li J, Luo X, Schultz PG. Genetic Incorporation of a Reactive Isothiocyanate Group into Proteins. Angewandte Chemie (International Ed. in English). PMID 27418387 DOI: 10.1002/Anie.201604891  0.807
2016 Xiao H, Schultz PG. At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code. Cold Spring Harbor Perspectives in Biology. PMID 27413101 DOI: 10.1101/Cshperspect.A023945  0.598
2016 Mehta AP, Li H, Reed SA, Supekova L, Javahishvili T, Schultz PG. Replacement of Thymidine by a Modified Base in the Escherichia coli Genome. Journal of the American Chemical Society. 138: 7272-5. PMID 27213685 DOI: 10.1021/Jacs.6B03904  0.773
2016 Abdeen S, Salim N, Mammadova N, Summers CM, Frankson R, Ambrose AJ, Anderson GG, Schultz PG, Horwich AL, Chapman E, Johnson SM. GroEL/ES inhibitors as potential antibiotics. Bioorganic & Medicinal Chemistry Letters. 26: 3127-34. PMID 27184767 DOI: 10.1016/J.Bmcl.2016.04.089  0.534
2016 Liu T, Wang Y, Luo X, Li J, Reed SA, Xiao H, Young TS, Schultz PG. Enhancing protein stability with extended disulfide bonds. Proceedings of the National Academy of Sciences of the United States of America. 113: 5910-5. PMID 27162342 DOI: 10.1073/Pnas.1605363113  0.805
2016 Cao Y, Rodgers DT, Du J, Ahmad I, Hampton EN, Ma JS, Mazagova M, Choi SH, Yun HY, Xiao H, Yang P, Luo X, Lim RK, Pugh HM, Wang F, ... ... Schultz PG, et al. Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer. Angewandte Chemie (International Ed. in English). 55: 7520-4. PMID 27145250 DOI: 10.1002/Anie.201601902  0.787
2016 Lee TC, Kang M, Kim CH, Schultz PG, Chapman E, Deniz AA. Dual Unnatural Amino Acid Incorporation and Click-Chemistry Labeling to Enable Single-Molecule FRET Studies of p97 Folding. Chembiochem : a European Journal of Chemical Biology. 17: 981-4. PMID 27115850 DOI: 10.1002/Cbic.201500695  0.801
2016 Yang PY, Zou H, Chao E, Sherwood L, Nunez V, Keeney M, Ghartey-Tagoe E, Ding Z, Quirino H, Luo X, Welzel G, Chen G, Singh P, Woods AK, Schultz PG, et al. Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery. Proceedings of the National Academy of Sciences of the United States of America. 113: 4140-5. PMID 27035989 DOI: 10.1073/Pnas.1601653113  0.775
2016 Luo X, Zambaldo C, Liu T, Zhang Y, Xuan W, Wang C, Reed SA, Yang PY, Wang RE, Javahishvili T, Schultz PG, Young TS. Recombinant thiopeptides containing noncanonical amino acids. Proceedings of the National Academy of Sciences of the United States of America. 113: 3615-20. PMID 26976568 DOI: 10.1073/Pnas.1602733113  0.806
2016 Rodgers DT, Mazagova M, Hampton EN, Cao Y, Ramadoss NS, Hardy IR, Schulman A, Du J, Wang F, Singer O, Ma J, Nunez V, Shen J, Woods AK, Wright TM, ... Schultz PG, et al. Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies. Proceedings of the National Academy of Sciences of the United States of America. 113: E459-68. PMID 26759369 DOI: 10.1073/Pnas.1524155113  0.786
2016 Ma JS, Kim JY, Kazane SA, Choi SH, Yun HY, Kim MS, Rodgers DT, Pugh HM, Singer O, Sun SB, Fonslow BR, Kochenderfer JN, Wright TM, Schultz PG, Young TS, et al. Versatile strategy for controlling the specificity and activity of engineered T cells. Proceedings of the National Academy of Sciences of the United States of America. 113: E450-8. PMID 26759368 DOI: 10.1073/Pnas.1524193113  0.796
2016 Kern JC, Cancilla M, Dooney D, Kwasnjuk K, Zhang R, Beaumont M, Figueroa I, Hsieh S, Liang L, Tomazela D, Zhang J, Brandish PE, Palmieri A, Stivers P, Cheng M, ... ... Schultz PG, et al. Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody-Drug Conjugates. Journal of the American Chemical Society. 138: 1430-45. PMID 26745435 DOI: 10.1021/Jacs.5B12547  0.528
2016 Muppidi A, Zou H, Yang PY, Chao E, Sherwood L, Nunez V, Woods AK, Schultz PG, Lin Q, Shen W. Design of Potent and Proteolytically Stable Oxyntomodulin Analogs. Acs Chemical Biology. 11: 324-8. PMID 26727558 DOI: 10.1021/Acschembio.5B00787  0.774
2016 Novotny CJ, Pollari S, Park JH, Lemmon MA, Schultz PG, Shen W, Shokat KM. Abstract 3904: Overcoming resistance to HER2 inhibitors through cell based screening Cancer Research. 76: 3904-3904. DOI: 10.1158/1538-7445.Am2016-3904  0.633
2016 Zhang Z, English BP, Grimm JB, Kazane SA, Hu W, Tsai A, Inouye C, You C, Piehler J, Schultz PG, Lavis LD, Revyakin A, Tjian R. Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis Genes and Development. 30: 2106-2118. DOI: 10.1101/gad.285395.116  0.705
2016 Lee TC, Kang M, Kim CH, Schultz PG, Chapman E, Deniz AA. Cover Picture: Dual Unnatural Amino Acid Incorporation and Click-Chemistry Labeling to Enable Single-Molecule FRET Studies of p97 Folding (ChemBioChem 11/2016) Chembiochem. 17: 969-969. DOI: 10.1002/Cbic.201600277  0.796
2015 Luo X, Liu T, Wang Y, Jia H, Zhang Y, Caballero D, Du J, Wang RE, Wang D, Schultz PG, Wang F. An Epitope-Specific Respiratory Syncytial Virus Vaccine Based on an Antibody Scaffold. Angewandte Chemie (International Ed. in English). 54: 14531-4. PMID 26434555 DOI: 10.1002/Anie.201507928  0.785
2015 Bollong MJ, Yun H, Sherwood L, Woods AK, Lairson LL, Schultz PG. A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer. Acs Chemical Biology. 10: 2193-8. PMID 26270491 DOI: 10.1021/Acschembio.5B00448  0.793
2015 Liu T, Du J, Luo X, Schultz PG, Wang F. Homogeneously modified immunoglobulin domains for therapeutic application. Current Opinion in Chemical Biology. 28: 66-74. PMID 26117722 DOI: 10.1016/J.Cbpa.2015.06.007  0.652
2015 Xiao H, Nasertorabi F, Choi SH, Han GW, Reed SA, Stevens RC, Schultz PG. Exploring the potential impact of an expanded genetic code on protein function. Proceedings of the National Academy of Sciences of the United States of America. 112: 6961-6. PMID 26038548 DOI: 10.1073/Pnas.1507741112  0.804
2015 Lim RK, Yu S, Cheng B, Li S, Kim NJ, Cao Y, Chi V, Kim JY, Chatterjee AK, Schultz PG, Tremblay MS, Kazane SA. Targeted Delivery of LXR Agonist Using a Site-Specific Antibody-Drug Conjugate. Bioconjugate Chemistry. 26: 2216-22. PMID 25945727 DOI: 10.1021/Acs.Bioconjchem.5B00203  0.803
2015 Cao Y, Axup JY, Ma JS, Wang RE, Choi S, Tardif V, Lim RK, Pugh HM, Lawson BR, Welzel G, Kazane SA, Sun Y, Tian F, Srinagesh S, Javahishvili T, ... Schultz PG, et al. Multiformat T-cell-engaging bispecific antibodies targeting human breast cancers. Angewandte Chemie (International Ed. in English). 54: 7022-7. PMID 25919418 DOI: 10.1002/Anie.201500799  0.798
2015 Xiao H, Xuan W, Shao S, Liu T, Schultz PG. Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones. Acs Chemical Biology. 10: 1599-603. PMID 25909834 DOI: 10.1021/Cb501055H  0.758
2015 Harbut MB, Vilchèze C, Luo X, Hensler ME, Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR, Schultz PG, Wang F. Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 112: 4453-8. PMID 25831516 DOI: 10.1073/Pnas.1504022112  0.777
2015 Liu T, Fu G, Luo X, Liu Y, Wang Y, Wang RE, Schultz PG, Wang F. Rational design of antibody protease inhibitors. Journal of the American Chemical Society. 137: 4042-5. PMID 25775396 DOI: 10.1021/Ja5130786  0.798
2015 Pearson AD, Mills JH, Song Y, Nasertorabi F, Han GW, Baker D, Stevens RC, Schultz PG. Transition states. Trapping a transition state in a computationally designed protein bottle. Science (New York, N.Y.). 347: 863-7. PMID 25700516 DOI: 10.1126/Science.Aaa2424  0.785
2015 Wang RE, Liu T, Wang Y, Cao Y, Du J, Luo X, Deshmukh V, Kim CH, Lawson BR, Tremblay MS, Young TS, Kazane SA, Wang F, Schultz PG. An immunosuppressive antibody-drug conjugate. Journal of the American Chemical Society. 137: 3229-32. PMID 25699419 DOI: 10.1021/Jacs.5B00620  0.8
2015 Kim MS, Ma JS, Yun H, Cao Y, Kim JY, Chi V, Wang D, Woods A, Sherwood L, Caballero D, Gonzalez J, Schultz PG, Young TS, Kim CH. Redirection of genetically engineered CAR-T cells using bifunctional small molecules. Journal of the American Chemical Society. 137: 2832-5. PMID 25692571 DOI: 10.1021/Jacs.5B00106  0.791
2015 Liu T, Zhang Y, Liu Y, Wang Y, Jia H, Kang M, Luo X, Caballero D, Gonzalez J, Sherwood L, Nunez V, Wang D, Woods A, Schultz PG, Wang F. Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists. Proceedings of the National Academy of Sciences of the United States of America. 112: 1356-61. PMID 25605877 DOI: 10.1073/Pnas.1423668112  0.796
2015 Zhang Y, Zou H, Wang Y, Caballero D, Gonzalez J, Chao E, Welzel G, Shen W, Wang D, Schultz PG, Wang F. Rational design of a humanized glucagon-like peptide-1 receptor agonist antibody. Angewandte Chemie (International Ed. in English). 54: 2126-30. PMID 25556336 DOI: 10.1002/Anie.201410049  0.793
2015 Zhang Y, Liu Y, Wang Y, Schultz PG, Wang F. Rational design of humanized dual-agonist antibodies. Journal of the American Chemical Society. 137: 38-41. PMID 25494484 DOI: 10.1021/Ja510519U  0.512
2014 Decker RS, Koyama E, Enomoto-Iwamoto M, Maye P, Rowe D, Zhu S, Schultz PG, Pacifici M. Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin. Developmental Biology. 395: 255-67. PMID 25238962 DOI: 10.1016/J.Ydbio.2014.09.011  0.509
2014 Kularatne SA, Deshmukh V, Ma J, Tardif V, Lim RK, Pugh HM, Sun Y, Manibusan A, Sellers AJ, Barnett RS, Srinagesh S, Forsyth JS, Hassenpflug W, Tian F, Javahishvili T, ... ... Schultz PG, et al. A CXCR4-targeted site-specific antibody-drug conjugate. Angewandte Chemie (International Ed. in English). 53: 11863-7. PMID 25213874 DOI: 10.1002/Anie.201408103  0.802
2014 Larman HB, Scott ER, Wogan M, Oliveira G, Torkamani A, Schultz PG. Sensitive, multiplex and direct quantification of RNA sequences using a modified RASL assay. Nucleic Acids Research. 42: 9146-57. PMID 25063296 DOI: 10.1093/Nar/Gku636  0.774
2014 Lu H, Zhou Q, Deshmukh V, Phull H, Ma J, Tardif V, Naik RR, Bouvard C, Zhang Y, Choi S, Lawson BR, Zhu S, Kim CH, Schultz PG. Targeting human C-type lectin-like molecule-1 (CLL1) with a bispecific antibody for immunotherapy of acute myeloid leukemia. Angewandte Chemie (International Ed. in English). 53: 9841-5. PMID 25056598 DOI: 10.1002/Anie.201405353  0.799
2014 Sun SB, Schultz PG, Kim CH. Therapeutic applications of an expanded genetic code. Chembiochem : a European Journal of Chemical Biology. 15: 1721-9. PMID 25044800 DOI: 10.1002/Cbic.201402154  0.809
2014 Liu T, Liu Y, Wang Y, Hull M, Schultz PG, Wang F. Rational design of CXCR4 specific antibodies with elongated CDRs. Journal of the American Chemical Society. 136: 10557-60. PMID 25041362 DOI: 10.1021/Ja5042447  0.544
2014 Chatterjee A, Lajoie MJ, Xiao H, Church GM, Schultz PG. A bacterial strain with a unique quadruplet codon specifying non-native amino acids. Chembiochem : a European Journal of Chemical Biology. 15: 1782-6. PMID 24867343 DOI: 10.1002/Cbic.201402104  0.672
2014 Furman JL, Kang M, Choi S, Cao Y, Wold ED, Sun SB, Smider VV, Schultz PG, Kim CH. A genetically encoded aza-Michael acceptor for covalent cross-linking of protein-receptor complexes. Journal of the American Chemical Society. 136: 8411-7. PMID 24846839 DOI: 10.1021/Ja502851H  0.814
2014 Kang M, Light K, Ai HW, Shen W, Kim CH, Chen PR, Lee HS, Solomon EI, Schultz PG. Evolution of iron(II)-finger peptides by using a bipyridyl amino acid. Chembiochem : a European Journal of Chemical Biology. 15: 822-5. PMID 24591102 DOI: 10.1002/Cbic.201300727  0.8
2014 Kessel C, Nandakumar KS, Peters FB, Gauba V, Schultz PG, Holmdahl R. A single functional group substitution in c5a breaks B cell and T cell tolerance and protects against experimental arthritis. Arthritis & Rheumatology (Hoboken, N.J.). 66: 610-21. PMID 24574221 DOI: 10.1002/Art.38237  0.751
2014 Xiao H, Peters FB, Yang PY, Reed S, Chittuluru JR, Schultz PG. Genetic incorporation of histidine derivatives using an engineered pyrrolysyl-tRNA synthetase. Acs Chemical Biology. 9: 1092-6. PMID 24506189 DOI: 10.1021/Cb500032C  0.809
2014 Tian F, Lu Y, Manibusan A, Sellers A, Tran H, Sun Y, Phuong T, Barnett R, Hehli B, Song F, DeGuzman MJ, Ensari S, Pinkstaff JK, Sullivan LM, Biroc SL, ... ... Schultz PG, et al. A general approach to site-specific antibody drug conjugates. Proceedings of the National Academy of Sciences of the United States of America. 111: 1766-71. PMID 24443552 DOI: 10.1073/Pnas.1321237111  0.693
2014 Johnson SM, Sharif O, Mak PA, Wang HT, Engels IH, Brinker A, Schultz PG, Horwich AL, Chapman E. A biochemical screen for GroEL/GroES inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 786-9. PMID 24418775 DOI: 10.1016/J.Bmcl.2013.12.100  0.761
2014 Rust HL, Subramanian V, West GM, Young DD, Schultz PG, Thompson PR. Using unnatural amino acid mutagenesis to probe the regulation of PRMT1. Acs Chemical Biology. 9: 649-55. PMID 24358983 DOI: 10.1021/Cb400859Z  0.804
2014 Zhang Y, Goswami D, Wang D, Wang TS, Sen S, Magliery TJ, Griffin PR, Wang F, Schultz PG. An antibody with a variable-region coiled-coil "knob" domain. Angewandte Chemie (International Ed. in English). 53: 132-5. PMID 24254636 DOI: 10.1002/Anie.201307939  0.796
2013 Kularatne SA, Deshmukh V, Gymnopoulos M, Biroc SL, Xia J, Srinagesh S, Sun Y, Zou N, Shimazu M, Pinkstaff J, Ensari S, Knudsen N, Manibusan A, Axup JY, Kim CH, ... ... Schultz PG, et al. Recruiting cytotoxic T cells to folate-receptor-positive cancer cells. Angewandte Chemie (International Ed. in English). 52: 12101-4. PMID 24573789 DOI: 10.1002/Anie.201306866  0.792
2013 Xiao H, Chatterjee A, Choi SH, Bajjuri KM, Sinha SC, Schultz PG. Genetic incorporation of multiple unnatural amino acids into proteins in mammalian cells. Angewandte Chemie (International Ed. in English). 52: 14080-3. PMID 24353230 DOI: 10.1002/Anie.201308137  0.741
2013 Liu J, Pan S, Hsieh MH, Ng N, Sun F, Wang T, Kasibhatla S, Schuller AG, Li AG, Cheng D, Li J, Tompkins C, Pferdekamper A, Steffy A, Cheng J, ... ... Schultz PG, et al. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proceedings of the National Academy of Sciences of the United States of America. 110: 20224-9. PMID 24277854 DOI: 10.1073/Pnas.1314239110  0.637
2013 Lajoie MJ, Rovner AJ, Goodman DB, Aerni HR, Haimovich AD, Kuznetsov G, Mercer JA, Wang HH, Carr PA, Mosberg JA, Rohland N, Schultz PG, Jacobson JM, Rinehart J, Church GM, et al. Genomically recoded organisms expand biological functions. Science (New York, N.Y.). 342: 357-60. PMID 24136966 DOI: 10.1126/Science.1241459  0.315
2013 Kim CH, Axup JY, Lawson BR, Yun H, Tardif V, Choi SH, Zhou Q, Dubrovska A, Biroc SL, Marsden R, Pinstaff J, Smider VV, Schultz PG. Bispecific small molecule-antibody conjugate targeting prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 110: 17796-801. PMID 24127589 DOI: 10.1073/Pnas.1316026110  0.806
2013 Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, Padmanabhan K, Swoboda JG, Ahmad I, Kondo T, Gage FH, Theofilopoulos AN, Lawson BR, Schultz PG, Lairson LL. A regenerative approach to the treatment of multiple sclerosis. Nature. 502: 327-32. PMID 24107995 DOI: 10.1038/Nature12647  0.787
2013 Zhang Y, Wang D, Welzel G, Wang Y, Schultz PG, Wang F. An antibody CDR3-erythropoietin fusion protein. Acs Chemical Biology. 8: 2117-21. PMID 23941200 DOI: 10.1021/Cb4004749  0.771
2013 Chatterjee A, Guo J, Lee HS, Schultz PG. A genetically encoded fluorescent probe in mammalian cells. Journal of the American Chemical Society. 135: 12540-3. PMID 23924161 DOI: 10.1021/Ja4059553  0.778
2013 Lu H, Wang D, Kazane S, Javahishvili T, Tian F, Song F, Sellers A, Barnett B, Schultz PG. Site-specific antibody-polymer conjugates for siRNA delivery. Journal of the American Chemical Society. 135: 13885-91. PMID 23924037 DOI: 10.1021/Ja4059525  0.802
2013 Chatterjee A, Xiao H, Bollong M, Ai HW, Schultz PG. Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 11803-8. PMID 23818609 DOI: 10.1073/Pnas.1309584110  0.817
2013 Sun SB, Sen S, Kim NJ, Magliery TJ, Schultz PG, Wang F. Mutational analysis of 48G7 reveals that somatic hypermutation affects both antibody stability and binding affinity. Journal of the American Chemical Society. 135: 9980-3. PMID 23795814 DOI: 10.1021/ja402927u  0.781
2013 Zhang Y, Wang D, de Lichtervelde L, Sun SB, Smider VV, Schultz PG, Wang F. Functional antibody CDR3 fusion proteins with enhanced pharmacological properties. Angewandte Chemie (International Ed. in English). 52: 8295-8. PMID 23794517 DOI: 10.1002/Anie.201303656  0.804
2013 Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, ... ... Schultz PG, et al. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 110: E2510-7. PMID 23776209 DOI: 10.1073/Pnas.1309171110  0.793
2013 Wang F, Ekiert DC, Ahmad I, Yu W, Zhang Y, Bazirgan O, Torkamani A, Raudsepp T, Mwangi W, Criscitiello MF, Wilson IA, Schultz PG, Smider VV. Reshaping antibody diversity. Cell. 153: 1379-93. PMID 23746848 DOI: 10.1016/J.Cell.2013.04.049  0.763
2013 Kim CH, Axup JY, Schultz PG. Protein conjugation with genetically encoded unnatural amino acids. Current Opinion in Chemical Biology. 17: 412-9. PMID 23664497 DOI: 10.1016/J.Cbpa.2013.04.017  0.813
2013 Niu W, Schultz PG, Guo J. An expanded genetic code in mammalian cells with a functional quadruplet codon. Acs Chemical Biology. 8: 1640-5. PMID 23662731 DOI: 10.1021/Cb4001662  0.627
2013 Swoboda JG, Elliott J, Deshmukh V, de Lichtervelde L, Shen W, Tremblay MS, Peters EC, Cho CY, Lu B, Girman S, Wang S, Schultz PG. Small molecule mediated proliferation of primary retinal pigment epithelial cells. Acs Chemical Biology. 8: 1407-11. PMID 23621521 DOI: 10.1021/Cb4001712  0.777
2013 Chatterjee A, Xiao H, Yang PY, Soundararajan G, Schultz PG. A tryptophanyl-tRNA synthetase/tRNA pair for unnatural amino acid mutagenesis in E. coli. Angewandte Chemie (International Ed. in English). 52: 5106-9. PMID 23554007 DOI: 10.1002/Anie.201301094  0.81
2013 Day JW, Kim CH, Smider VV, Schultz PG. Identification of metal ion binding peptides containing unnatural amino acids by phage display. Bioorganic & Medicinal Chemistry Letters. 23: 2598-600. PMID 23541674 DOI: 10.1016/J.Bmcl.2013.02.106  0.79
2013 de Lichtervelde L, Boitano AE, Wang Y, Krastel P, Petersen F, Cooke MP, Schultz PG. Eupalinilide E inhibits erythropoiesis and promotes the expansion of hematopoietic progenitor cells. Acs Chemical Biology. 8: 866-70. PMID 23441826 DOI: 10.1021/Cb4000234  0.789
2013 Wang F, Sen S, Zhang Y, Ahmad I, Zhu X, Wilson IA, Smider VV, Magliery TJ, Schultz PG. Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation. Proceedings of the National Academy of Sciences of the United States of America. 110: 4261-6. PMID 23440204 DOI: 10.1073/Pnas.1301810110  0.792
2013 Chatterjee A, Sun SB, Furman JL, Xiao H, Schultz PG. A versatile platform for single- and multiple-unnatural amino acid mutagenesis in Escherichia coli. Biochemistry. 52: 1828-37. PMID 23379331 DOI: 10.1021/Bi4000244  0.81
2013 Shen W, Tremblay MS, Deshmukh VA, Wang W, Filippi CM, Harb G, Zhang YQ, Kamireddy A, Baaten JE, Jin Q, Wu T, Swoboda JG, Cho CY, Li J, Laffitte BA, ... ... Schultz PG, et al. Small-molecule inducer of β cell proliferation identified by high-throughput screening. Journal of the American Chemical Society. 135: 1669-72. PMID 23330637 DOI: 10.1021/Ja309304M  0.795
2013 Lairson LL, Lyssiotis CA, Zhu S, Schultz PG. Small molecule-based approaches to adult stem cell therapies. Annual Review of Pharmacology and Toxicology. 53: 107-25. PMID 23294307 DOI: 10.1146/Annurev-Pharmtox-011112-140300  0.764
2013 Kazane SA, Axup JY, Kim CH, Ciobanu M, Wold ED, Barluenga S, Hutchins BA, Schultz PG, Winssinger N, Smider VV. Self-assembled antibody multimers through peptide nucleic acid conjugation. Journal of the American Chemical Society. 135: 340-6. PMID 23210862 DOI: 10.1021/Ja309505C  0.803
2013 Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, ... ... Schultz PG, et al. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis (vol 110, pg E2510, 2013) Proceedings of the National Academy of Sciences of the United States of America. 110: 15848-15848. DOI: 10.1073/Pnas.1315914110  0.768
2013 Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, ... ... Schultz PG, et al. Erratum: Identification of a small molecule with activity against drug-resistant and persistent tuberculosis (Proceedings of the National Academy of Sciences of the United States of America (2013) 27:110 (E2510-E2517)) Proceedings of the National Academy of Sciences of the United States of America. 110. DOI: 10.1073/Pnas.1314629110  0.767
2013 Shen W, Tremblay MS, Deshmukh VA, Wang W, Filippi CM, Harb G, Zhang Y, Kamireddy A, Baaten JE, Jin Q, Wu T, Swoboda JG, Peters EC, Cho CY, Li J, ... ... Schultz PG, et al. Correction to “Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening” Journal of the American Chemical Society. 135: 4573-4573. DOI: 10.1021/Ja401118G  0.769
2012 Axup JY, Bajjuri KM, Ritland M, Hutchins BM, Kim CH, Kazane SA, Halder R, Forsyth JS, Santidrian AF, Stafin K, Lu Y, Tran H, Seller AJ, Biroc SL, Szydlik A, ... ... Schultz PG, et al. Synthesis of site-specific antibody-drug conjugates using unnatural amino acids. Proceedings of the National Academy of Sciences of the United States of America. 109: 16101-6. PMID 22988081 DOI: 10.1073/Pnas.1211023109  0.815
2012 Wang F, Niu W, Guo J, Schultz PG. Unnatural amino acid mutagenesis of fluorescent proteins. Angewandte Chemie (International Ed. in English). 51: 10132-5. PMID 22951916 DOI: 10.1002/Anie.201204668  0.616
2012 Chatterjee A, Xiao H, Schultz PG. Evolution of multiple, mutually orthogonal prolyl-tRNA synthetase/tRNA pairs for unnatural amino acid mutagenesis in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 109: 14841-6. PMID 22927411 DOI: 10.1073/Pnas.1212454109  0.691
2012 de Lichtervelde L, Antal CE, Boitano AE, Wang Y, Krastel P, Petersen F, Newton AC, Cooke MP, Schultz PG. Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation. Chemistry & Biology. 19: 994-1000. PMID 22921066 DOI: 10.1016/J.Chembiol.2012.06.010  0.794
2012 Wang D, Wang J, Bonamy GM, Meeusen S, Brusch RG, Turk C, Yang P, Schultz PG. A small molecule promotes mitochondrial fusion in mammalian cells. Angewandte Chemie (International Ed. in English). 51: 9302-5. PMID 22907892 DOI: 10.1002/Anie.201204589  0.776
2012 Boitano AE, de Lichtervelde L, Snead JL, Cooke MP, Schultz PG. An image-based screen identifies a small molecule regulator of megakaryopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 14019-23. PMID 22891346 DOI: 10.1073/Pnas.1212545109  0.792
2012 Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T, Welsh DK, Brenner DA, Doyle FJ, Schultz PG, Kay SA. Identification of small molecule activators of cryptochrome. Science (New York, N.Y.). 337: 1094-7. PMID 22798407 DOI: 10.1126/Science.1223710  0.719
2012 Kim CH, Kang M, Kim HJ, Chatterjee A, Schultz PG. Site-specific incorporation of ε-N-crotonyllysine into histones. Angewandte Chemie (International Ed. in English). 51: 7246-9. PMID 22689270 DOI: 10.1002/Anie.201203349  0.803
2012 Dubrovska A, Hartung A, Bouchez LC, Walker JR, Reddy VA, Cho CY, Schultz PG. CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling. British Journal of Cancer. 107: 43-52. PMID 22644306 DOI: 10.1038/Bjc.2012.105  0.779
2012 Kim CH, Axup JY, Dubrovska A, Kazane SA, Hutchins BA, Wold ED, Smider VV, Schultz PG. Synthesis of bispecific antibodies using genetically encoded unnatural amino acids. Journal of the American Chemical Society. 134: 9918-21. PMID 22642368 DOI: 10.1021/Ja303904E  0.803
2012 Johnson K, Zhu S, Tremblay MS, Payette JN, Wang J, Bouchez LC, Meeusen S, Althage A, Cho CY, Wu X, Schultz PG. A stem cell-based approach to cartilage repair. Science (New York, N.Y.). 336: 717-21. PMID 22491093 DOI: 10.1126/Science.1215157  0.786
2012 Dubrovska A, Elliott J, Salamone RJ, Telegeev GD, Stakhovsky AE, Schepotin IB, Yan F, Wang Y, Bouchez LC, Kularatne SA, Watson J, Trussell C, Reddy VA, Cho CY, Schultz PG. CXCR4 expression in prostate cancer progenitor cells. Plos One. 7: e31226. PMID 22359577 DOI: 10.1371/Journal.Pone.0031226  0.773
2012 Kazane SA, Sok D, Cho EH, Uson ML, Kuhn P, Schultz PG, Smider VV. Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR. Proceedings of the National Academy of Sciences of the United States of America. 109: 3731-6. PMID 22345566 DOI: 10.1073/Pnas.1120682109  0.802
2012 Tianero MD, Donia MS, Young TS, Schultz PG, Schmidt EW. Ribosomal route to small-molecule diversity. Journal of the American Chemical Society. 134: 418-25. PMID 22107593 DOI: 10.1021/Ja208278K  0.799
2011 Gonzalez R, Lee JW, Schultz PG. Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells. Angewandte Chemie (International Ed. in English). 50: 11181-5. PMID 22191091 DOI: 10.1002/Anie.201103909  0.775
2011 Meister S, Plouffe DM, Kuhen KL, Bonamy GM, Wu T, Barnes SW, Bopp SE, Borboa R, Bright AT, Che J, Cohen S, Dharia NV, Gagaring K, Gettayacamin M, Gordon P, ... ... Schultz PG, et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (New York, N.Y.). 334: 1372-7. PMID 22096101 DOI: 10.1126/Science.1211936  0.779
2011 Young DD, Jockush S, Turro NJ, Schultz PG. Synthetase polyspecificity as a tool to modulate protein function. Bioorganic & Medicinal Chemistry Letters. 21: 7502-4. PMID 22041062 DOI: 10.1016/J.Bmcl.2011.09.108  0.809
2011 Lee JW, Hirota T, Peters EC, Garcia M, Gonzalez R, Cho CY, Wu X, Schultz PG, Kay SA. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angewandte Chemie (International Ed. in English). 50: 10608-11. PMID 21954091 DOI: 10.1002/Anie.201103915  0.789
2011 Shoji S, Dambacher CM, Shajani Z, Williamson JR, Schultz PG. Systematic chromosomal deletion of bacterial ribosomal protein genes. Journal of Molecular Biology. 413: 751-61. PMID 21945294 DOI: 10.1016/J.Jmb.2011.09.004  0.775
2011 Dubrovska A, Kim C, Elliott J, Shen W, Kuo TH, Koo DI, Li C, Tuntland T, Chang J, Groessl T, Wu X, Gorney V, Ramirez-Montagut T, Spiegel DA, Cho CY, ... Schultz PG, et al. A chemically induced vaccine strategy for prostate cancer. Acs Chemical Biology. 6: 1223-31. PMID 21936526 DOI: 10.1021/Cb200222S  0.789
2011 Minnihan EC, Young DD, Schultz PG, Stubbe J. Incorporation of fluorotyrosines into ribonucleotide reductase using an evolved, polyspecific aminoacyl-tRNA synthetase. Journal of the American Chemical Society. 133: 15942-5. PMID 21913683 DOI: 10.1021/Ja207719F  0.773
2011 Charbon G, Wang J, Brustad E, Schultz PG, Horwich AL, Jacobs-Wagner C, Chapman E. Localization of GroEL determined by in vivo incorporation of a fluorescent amino acid. Bioorganic & Medicinal Chemistry Letters. 21: 6067-70. PMID 21890355 DOI: 10.1016/J.Bmcl.2011.08.057  0.803
2011 Berezhna SY, Supekova L, Sever MJ, Schultz PG, Deniz AA. Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodies. Rna (New York, N.Y.). 17: 1831-45. PMID 21868483 DOI: 10.1261/Rna.2523911  0.773
2011 Nam TG, McNamara CW, Bopp S, Dharia NV, Meister S, Bonamy GM, Plouffe DM, Kato N, McCormack S, Bursulaya B, Ke H, Vaidya AB, Schultz PG, Winzeler EA. A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor. Acs Chemical Biology. 6: 1214-22. PMID 21866942 DOI: 10.1021/Cb200105D  0.603
2011 Liu J, Johnson K, Li J, Piamonte V, Steffy BM, Hsieh MH, Ng N, Zhang J, Walker JR, Ding S, Muneoka K, Wu X, Glynne R, Schultz PG. Regenerative phenotype in mice with a point mutation in transforming growth factor beta type I receptor (TGFBR1). Proceedings of the National Academy of Sciences of the United States of America. 108: 14560-5. PMID 21841138 DOI: 10.1073/Pnas.1111056108  0.779
2011 Thielges MC, Axup JY, Wong D, Lee HS, Chung JK, Schultz PG, Fayer MD. Two-dimensional IR spectroscopy of protein dynamics using two vibrational labels: a site-specific genetically encoded unnatural amino acid and an active site ligand. The Journal of Physical Chemistry. B. 115: 11294-304. PMID 21823631 DOI: 10.1021/Jp206986V  0.787
2011 Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira JP, Guerini D, Baumgarten BU, Roggo S, Wen B, Knochenmuss R, Noël S, Gessier F, Kelly LM, Vanek M, ... ... Schultz PG, et al. Oxysterols direct immune cell migration via EBI2. Nature. 475: 524-7. PMID 21796212 DOI: 10.1038/Nature10280  0.792
2011 Gauba V, Grünewald J, Gorney V, Deaton LM, Kang M, Bursulaya B, Ou W, Lerner RA, Schmedt C, Geierstanger BH, Schultz PG, Ramirez-Montagut T. Loss of CD4 T-cell-dependent tolerance to proteins with modified amino acids. Proceedings of the National Academy of Sciences of the United States of America. 108: 12821-6. PMID 21768354 DOI: 10.1073/Pnas.1110042108  0.804
2011 Young TS, Young DD, Ahmad I, Louis JM, Benkovic SJ, Schultz PG. Evolution of cyclic peptide protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 108: 11052-6. PMID 21690365 DOI: 10.1073/Pnas.1108045108  0.79
2011 Charbon G, Brustad E, Scott KA, Wang J, Løbner-Olesen A, Schultz PG, Jacobs-Wagner C, Chapman E. Subcellular protein localization by using a genetically encoded fluorescent amino acid. Chembiochem : a European Journal of Chemical Biology. 12: 1818-21. PMID 21681882 DOI: 10.1002/Cbic.201100282  0.795
2011 Ai HW, Shen W, Sagi A, Chen PR, Schultz PG. Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid. Chembiochem : a European Journal of Chemical Biology. 12: 1854-7. PMID 21678540 DOI: 10.1002/Cbic.201100194  0.798
2011 Cho H, Daniel T, Buechler YJ, Litzinger DC, Maio Z, Putnam AM, Kraynov VS, Sim BC, Bussell S, Javahishvili T, Kaphle S, Viramontes G, Ong M, Chu S, Becky GC, ... ... Schultz PG, et al. Optimized clinical performance of growth hormone with an expanded genetic code. Proceedings of the National Academy of Sciences of the United States of America. 108: 9060-5. PMID 21576502 DOI: 10.1073/Pnas.1100387108  0.772
2011 Staerk J, Lyssiotis CA, Medeiro LA, Bollong M, Foreman RK, Zhu S, Garcia M, Gao Q, Bouchez LC, Lairson LL, Charette BD, Supekova L, Janes J, Brinker A, Cho CY, ... ... Schultz PG, et al. Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells. Angewandte Chemie (International Ed. in English). 50: 5734-6. PMID 21547985 DOI: 10.1002/Anie.201101042  0.801
2011 Tao H, Jin Q, Koo DI, Liao X, Englund NP, Wang Y, Ramamurthy A, Schultz PG, Dorsch M, Kelleher J, Wu X. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chemistry & Biology. 18: 432-7. PMID 21513879 DOI: 10.1016/J.Chembiol.2011.01.018  0.788
2011 Hutchins BM, Kazane SA, Staflin K, Forsyth JS, Felding-Habermann B, Smider VV, Schultz PG. Selective formation of covalent protein heterodimers with an unnatural amino acid. Chemistry & Biology. 18: 299-303. PMID 21439474 DOI: 10.1016/J.Chembiol.2011.01.006  0.815
2011 Nam TG, Lee J, Walker JR, Brinker A, Cho CY, Schultz PG. Identification and characterization of small-molecule inducers of fetal hemoglobin. Chemmedchem. 6: 777-80. PMID 21416611 DOI: 10.1002/Cmdc.201000505  0.772
2011 Gonzalez R, Lee JW, Snyder EY, Schultz PG. Dorsomorphin promotes human embryonic stem cell self-renewal. Angewandte Chemie (International Ed. in English). 50: 3439-41. PMID 21384475 DOI: 10.1002/Anie.201005659  0.765
2011 Bouchez LC, Boitano AE, de Lichtervelde L, Romeo R, Cooke MP, Schultz PG. Small-molecule regulators of human stem cell self-renewal. Chembiochem : a European Journal of Chemical Biology. 12: 854-7. PMID 21381174 DOI: 10.1002/Cbic.201000734  0.776
2011 Young DD, Young TS, Jahnz M, Ahmad I, Spraggon G, Schultz PG. An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity. Biochemistry. 50: 1894-900. PMID 21280675 DOI: 10.1021/Bi101929E  0.801
2011 Hutchins BM, Kazane SA, Staflin K, Forsyth JS, Felding-Habermann B, Schultz PG, Smider VV. Site-specific coupling and sterically controlled formation of multimeric antibody fab fragments with unnatural amino acids. Journal of Molecular Biology. 406: 595-603. PMID 21237172 DOI: 10.1016/J.Jmb.2011.01.011  0.816
2011 Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Chemical control of stem cell fate and developmental potential. Angewandte Chemie (International Ed. in English). 50: 200-42. PMID 21184400 DOI: 10.1002/Anie.201004284  0.787
2011 Fleissner MR, Bridges MD, Kálai T, Axup JY, Young D, Hideg K, Schultz PG, Hubbell WL. Applications of Genetically Encoded Unnatural Amino Acids for Protein Structure Mapping by Site-Directed Spin Labeling Biophysical Journal. 100: 51a. DOI: 10.1016/J.Bpj.2010.12.478  0.795
2011 Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. ChemInform Abstract: Chemical Control of Stem Cell Fate and Developmental Potential Cheminform. 42: no-no. DOI: 10.1002/chin.201116267  0.684
2010 Zhu S, Wurdak H, Schultz PG. Directed embryonic stem cell differentiation with small molecules. Future Medicinal Chemistry. 2: 965-73. PMID 21426114 DOI: 10.4155/Fmc.10.190  0.745
2010 Hirota T, Lee JW, Lewis WG, Zhang EE, Breton G, Liu X, Garcia M, Peters EC, Etchegaray JP, Traver D, Schultz PG, Kay SA. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. Plos Biology. 8: e1000559. PMID 21179498 DOI: 10.1371/Journal.Pbio.1000559  0.713
2010 Dubrovska A, Elliott J, Salamone RJ, Kim S, Aimone LJ, Walker JR, Watson J, Sauveur-Michel M, Garcia-Echeverria C, Cho CY, Reddy VA, Schultz PG. Combination therapy targeting both tumor-initiating and differentiated cell populations in prostate carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 5692-702. PMID 21138868 DOI: 10.1158/1078-0432.Ccr-10-1601  0.708
2010 Groff D, Wang F, Jockusch S, Turro NJ, Schultz PG. A new strategy to photoactivate green fluorescent protein. Angewandte Chemie (International Ed. in English). 49: 7677-9. PMID 20836111 DOI: 10.1002/Anie.201003797  0.774
2010 Wurdak H, Zhu S, Min KH, Aimone L, Lairson LL, Watson J, Chopiuk G, Demas J, Charette B, Halder R, Weerapana E, Cravatt BF, Cline HT, Peters EC, Zhang J, ... ... Schultz PG, et al. A small molecule accelerates neuronal differentiation in the adult rat. Proceedings of the National Academy of Sciences of the United States of America. 107: 16542-7. PMID 20823227 DOI: 10.1073/Pnas.1010300107  0.778
2010 Hu XV, Rodrigues TM, Tao H, Baker RK, Miraglia L, Orth AP, Lyons GE, Schultz PG, Wu X. Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen. Proceedings of the National Academy of Sciences of the United States of America. 107: 15087-92. PMID 20696907 DOI: 10.1073/Pnas.1009025107  0.781
2010 Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science (New York, N.Y.). 329: 1345-8. PMID 20688981 DOI: 10.1126/Science.1191536  0.787
2010 Teo H, Ghosh S, Luesch H, Ghosh A, Wong ET, Malik N, Orth A, de Jesus P, Perry AS, Oliver JD, Tran NL, Speiser LJ, Wong M, Saez E, Schultz P, et al. Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nature Cell Biology. 12: 758-67. PMID 20622870 DOI: 10.1038/Ncb2080  0.716
2010 Ai HW, Lee JW, Schultz PG. A method to site-specifically introduce methyllysine into proteins in E. coli. Chemical Communications (Cambridge, England). 46: 5506-8. PMID 20571694 DOI: 10.1039/C0Cc00108B  0.758
2010 Hur W, Sun Z, Jiang T, Mason DE, Peters EC, Zhang DD, Luesch H, Schultz PG, Gray NS. A small-molecule inducer of the antioxidant response element. Chemistry & Biology. 17: 537-47. PMID 20534351 DOI: 10.1016/J.Chembiol.2010.03.013  0.637
2010 Groff D, Chen PR, Peters FB, Schultz PG. A genetically encoded epsilon-N-methyl lysine in mammalian cells. Chembiochem : a European Journal of Chemical Biology. 11: 1066-8. PMID 20422671 DOI: 10.1002/Cbic.200900690  0.787
2010 Liu CC, Schultz PG. Adding new chemistries to the genetic code. Annual Review of Biochemistry. 79: 413-44. PMID 20307192 DOI: 10.1146/Annurev.Biochem.052308.105824  0.414
2010 Supekova L, Supek F, Greer JE, Schultz PG. A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression. Proceedings of the National Academy of Sciences of the United States of America. 107: 5047-52. PMID 20194738 DOI: 10.1073/Pnas.1000735107  0.743
2010 Wang F, Robbins S, Guo J, Shen W, Schultz PG. Genetic incorporation of unnatural amino acids into proteins in Mycobacterium tuberculosis. Plos One. 5: e9354. PMID 20179771 DOI: 10.1371/Journal.Pone.0009354  0.711
2010 Young TS, Schultz PG. Beyond the canonical 20 amino acids: expanding the genetic lexicon. The Journal of Biological Chemistry. 285: 11039-44. PMID 20147747 DOI: 10.1074/Jbc.R109.091306  0.809
2010 Gonzalez R, Jennings LL, Knuth M, Orth AP, Klock HE, Ou W, Feuerhelm J, Hull MV, Koesema E, Wang Y, Zhang J, Wu C, Cho CY, Su AI, Batalov S, ... ... Schultz PG, et al. Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency. Proceedings of the National Academy of Sciences of the United States of America. 107: 3552-7. PMID 20133595 DOI: 10.1073/Pnas.0914019107  0.807
2010 Wurdak H, Zhu S, Romero A, Lorger M, Watson J, Chiang CY, Zhang J, Natu VS, Lairson LL, Walker JR, Trussell CM, Harsh GR, Vogel H, Felding-Habermann B, Orth AP, ... ... Schultz PG, et al. An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation. Cell Stem Cell. 6: 37-47. PMID 20085741 DOI: 10.1016/J.Stem.2009.11.002  0.787
2010 Ai HW, Shen W, Brustad E, Schultz PG. Genetically encoded alkenes in yeast. Angewandte Chemie (International Ed. in English). 49: 935-7. PMID 20025009 DOI: 10.1002/Anie.200905590  0.772
2010 Young TS, Ahmad I, Yin JA, Schultz PG. An enhanced system for unnatural amino acid mutagenesis in E. coli. Journal of Molecular Biology. 395: 361-74. PMID 19852970 DOI: 10.1016/J.Jmb.2009.10.030  0.807
2010 Jones DH, Cellitti SE, Hao X, Zhang Q, Jahnz M, Summerer D, Schultz PG, Uno T, Geierstanger BH. Site-specific labeling of proteins with NMR-active unnatural amino acids. Journal of Biomolecular Nmr. 46: 89-100. PMID 19669620 DOI: 10.1007/S10858-009-9365-4  0.803
2010 Fleissner MR, Brustad EM, Kálai T, Altenbach C, Cascio D, Peters FB, Hideg K, Peuker S, Schultz PG, Hubbell WL. Site-directed spin labeling of a genetically encoded unnatural amino acid (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 51 (21637-21642)) Proceedings of the National Academy of Sciences of the United States of America. 107: 5693. DOI: 10.1073/Pnas.1000908107  0.689
2010 Ding S, Gray NS, Ding Q, Schultz PG. ChemInform Abstract: Expanding the Diversity of Purine Libraries. Cheminform. 33: no-no. DOI: 10.1002/chin.200210137  0.337
2010 Liu DR, Schultz PG. ChemInform Abstract: Generating New Molecular Function: A Lesson from Nature Cheminform. 30: no-no. DOI: 10.1002/chin.199918258  0.315
2010 HALL DG, SCHULTZ PG. ChemInform Abstract: Synthesis of Diverse Ethoxyformacetal Oligomers. Toward Libraries of Metal-Coordinating Unnatural Biopolymers. Cheminform. 29: no-no. DOI: 10.1002/chin.199806117  0.392
2010 KIM J, WILSON TE, NORMAN TC, SCHULTZ PG. ChemInform Abstract: Synthesis of a Cyclic Urea as a Nonnatural Biopolymer Scaffold. Cheminform. 27: no-no. DOI: 10.1002/chin.199646211  0.769
2010 ULRICH HD, DRIGGERS EMG, SCHULTZ PG. ChemInform Abstract: Antibody Catalysis of Pericyclic Reactions Cheminform. 27: no-no. DOI: 10.1002/chin.199635311  0.536
2010 CORNISH VW, MENDEL D, SCHULTZ PG. ChemInform Abstract: Probing Protein Structure and Function with an Expanded Genetic Code Cheminform. 26: no-no. DOI: 10.1002/chin.199530300  0.558
2010 YU J, HSIEH LC, KOCHERSPERGER L, YONKOVICH S, STEPHANS JC, GALLOP MA, SCHULTZ PG. ChemInform Abstract: Progress Toward an Antibody Glycosidase. Cheminform. 25: no-no. DOI: 10.1002/chin.199422050  0.592
2010 SCHULTZ PG, LERNER RA. ChemInform Abstract: Antibody Catalysis of Difficult Chemical Transformations. Cheminform. 24: no-no. DOI: 10.1002/chin.199349319  0.392
2010 SCANLAN T, SCHULTZ PG. ChemInform Abstract: Recent Advances in Catalytic Antibodies Cheminform. 24: no-no. DOI: 10.1002/chin.199326260  0.632
2010 SCANLAN TS, PRUDENT JR, SCHULTZ PG. ChemInform Abstract: Antibody-Catalyzed Hydrolysis of Phosphate Monoesters. Cheminform. 23: no-no. DOI: 10.1002/chin.199212102  0.63
2010 SHOKAT KM, KO MK, SCANLAN TS, KOCHERSPERGER L, YONKOVICH S, THAISRIVONGS S, SCHULTZ PG. ChemInform Abstract: Catalytic Antibodies: A New Class of Transition-State Analogues Used to Elicit Hydrolytic Antibodies Cheminform. 22: no-no. DOI: 10.1002/chin.199108378  0.69
2010 Groff D, Chen PR, Peters FB, Schultz PG. Corrigendum: A Genetically Encoded ε-N-Methyl Lysine in Mammalian Cells Chembiochem. 11: 1009-1009. DOI: 10.1002/Cbic.201090036  0.763
2010 Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Chemische Kontrolle des Schicksals und Entwicklungspotenzials von Stammzellen Angewandte Chemie. 123: 210-256. DOI: 10.1002/Ange.201004284  0.751
2009 Liu CC, Cellitti SE, Geierstanger BH, Schultz PG. Efficient expression of tyrosine-sulfated proteins in E. coli using an expanded genetic code. Nature Protocols. 4: 1784-9. PMID 20010929 DOI: 10.1038/Nprot.2009.188  0.419
2009 Fleissner MR, Brustad EM, Kálai T, Altenbach C, Cascio D, Peters FB, Hideg K, Peuker S, Schultz PG, Hubbell WL. Site-directed spin labeling of a genetically encoded unnatural amino acid. Proceedings of the National Academy of Sciences of the United States of America. 106: 21637-42. PMID 19995976 DOI: 10.1073/Pnas.0912009106  0.772
2009 Zhang Z, Gildersleeve J, Yang YY, Xu R, Loo JA, Uryu S, Wong CH, Schultz PG. Retraction. Science (New York, N.Y.). 326: 1187. PMID 19965450 DOI: 10.1126/science.326.5957.1187-a  0.517
2009 Guo J, Melançon CE, Lee HS, Groff D, Schultz PG. Evolution of amber suppressor tRNAs for efficient bacterial production of proteins containing nonnatural amino acids. Angewandte Chemie (International Ed. in English). 48: 9148-51. PMID 19856359 DOI: 10.1002/Anie.200904035  0.801
2009 Jones CA, Nishiya N, London NR, Zhu W, Sorensen LK, Chan AC, Lim CJ, Chen H, Zhang Q, Schultz PG, Hayallah AM, Thomas KR, Famulok M, Zhang K, Ginsberg MH, et al. Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nature Cell Biology. 11: 1325-31. PMID 19855388 DOI: 10.1038/Ncb1976  0.537
2009 Zhu S, Wurdak H, Wang Y, Galkin A, Tao H, Li J, Lyssiotis CA, Yan F, Tu BP, Miraglia L, Walker J, Sun F, Orth A, Schultz PG, Wu X. A genomic screen identifies TYRO3 as a MITF regulator in melanoma. Proceedings of the National Academy of Sciences of the United States of America. 106: 17025-30. PMID 19805117 DOI: 10.1073/Pnas.0909292106  0.789
2009 Lemke EA, Gambin Y, Vandelinder V, Brustad EM, Liu HW, Schultz PG, Groisman A, Deniz AA. Microfluidic device for single-molecule experiments with enhanced photostability. Journal of the American Chemical Society. 131: 13610-2. PMID 19772358 DOI: 10.1021/Ja9027023  0.767
2009 Xu R, Hanson SR, Zhang Z, Yang YY, Schultz PG, Wong CH. Site-specific incorporation of the mucin-type N-acetylgalactosamine-alpha-O-threonine into protein in Escherichia coli. Journal of the American Chemical Society. 131: 13883. PMID 19731911 DOI: 10.1021/Ja906705A  0.627
2009 Liu CC, Choe H, Farzan M, Smider VV, Schultz PG. Mutagenesis and evolution of sulfated antibodies using an expanded genetic code. Biochemistry. 48: 8891-8. PMID 19715291 DOI: 10.1021/Bi9011429  0.693
2009 Lee HS, Guo J, Lemke EA, Dimla RD, Schultz PG. Genetic incorporation of a small, environmentally sensitive, fluorescent probe into proteins in Saccharomyces cerevisiae. Journal of the American Chemical Society. 131: 12921-3. PMID 19702307 DOI: 10.1021/Ja904896S  0.794
2009 Wu X, Schultz PG. Synthesis at the interface of chemistry and biology. Journal of the American Chemical Society. 131: 12497-515. PMID 19689159 DOI: 10.1021/Ja9026067  0.456
2009 Mills JH, Lee HS, Liu CC, Wang J, Schultz PG. A genetically encoded direct sensor of antibody-antigen interactions. Chembiochem : a European Journal of Chemical Biology. 10: 2162-4. PMID 19672911 DOI: 10.1002/Cbic.200900254  0.808
2009 Lee HS, Dimla RD, Schultz PG. Protein-DNA photo-crosslinking with a genetically encoded benzophenone-containing amino acid. Bioorganic & Medicinal Chemistry Letters. 19: 5222-4. PMID 19643606 DOI: 10.1016/J.Bmcl.2009.07.011  0.64
2009 Liu CC, Mack AV, Brustad EM, Mills JH, Groff D, Smider VV, Schultz PG. Evolution of proteins with genetically encoded "chemical warheads". Journal of the American Chemical Society. 131: 9616-7. PMID 19555063 DOI: 10.1021/Ja902985E  0.811
2009 Lyssiotis CA, Foreman RK, Staerk J, Garcia M, Mathur D, Markoulaki S, Hanna J, Lairson LL, Charette BD, Bouchez LC, Bollong M, Kunick C, Brinker A, Cho CY, Schultz PG, et al. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proceedings of the National Academy of Sciences of the United States of America. 106: 8912-7. PMID 19447925 DOI: 10.1073/Pnas.0903860106  0.792
2009 Zhu S, Wurdak H, Wang J, Lyssiotis CA, Peters EC, Cho CY, Wu X, Schultz PG. A small molecule primes embryonic stem cells for differentiation. Cell Stem Cell. 4: 416-26. PMID 19427291 DOI: 10.1016/J.Stem.2009.04.001  0.793
2009 Melançon CE, Schultz PG. One plasmid selection system for the rapid evolution of aminoacyl-tRNA synthetases. Bioorganic & Medicinal Chemistry Letters. 19: 3845-7. PMID 19398201 DOI: 10.1016/J.Bmcl.2009.04.007  0.727
2009 Chen PR, Groff D, Guo J, Ou W, Cellitti S, Geierstanger BH, Schultz PG. A facile system for encoding unnatural amino acids in mammalian cells. Angewandte Chemie (International Ed. in English). 48: 4052-5. PMID 19378306 DOI: 10.1002/Anie.200900683  0.809
2009 Groff D, Thielges MC, Cellitti S, Schultz PG, Romesberg FE. Efforts toward the direct experimental characterization of enzyme microenvironments: tyrosine100 in dihydrofolate reductase. Angewandte Chemie (International Ed. in English). 48: 3478-81. PMID 19347910 DOI: 10.1002/Anie.200806239  0.78
2009 Young TS, Ahmad I, Brock A, Schultz PG. Expanding the genetic repertoire of the methylotrophic yeast Pichia pastoris. Biochemistry. 48: 2643-53. PMID 19265424 DOI: 10.1021/Bi802178K  0.808
2009 Grünewald J, Hunt GS, Dong L, Niessen F, Wen BG, Tsao ML, Perera R, Kang M, Laffitte BA, Azarian S, Ruf W, Nasoff M, Lerner RA, Schultz PG, Smider VV. Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids. Proceedings of the National Academy of Sciences of the United States of America. 106: 4337-42. PMID 19246393 DOI: 10.1073/Pnas.0900507106  0.799
2009 Peters FB, Brock A, Wang J, Schultz PG. Photocleavage of the polypeptide backbone by 2-nitrophenylalanine. Chemistry & Biology. 16: 148-52. PMID 19246005 DOI: 10.1016/J.Chembiol.2009.01.013  0.802
2009 Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, Peters EC, Siuzdak G. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proceedings of the National Academy of Sciences of the United States of America. 106: 3698-703. PMID 19234110 DOI: 10.1073/Pnas.0812874106  0.623
2009 Lee HS, Spraggon G, Schultz PG, Wang F. Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe. Journal of the American Chemical Society. 131: 2481-3. PMID 19193005 DOI: 10.1021/Ja808340B  0.634
2009 Wang W, Walker JR, Wang X, Tremblay MS, Lee JW, Wu X, Schultz PG. Identification of small-molecule inducers of pancreatic beta-cell expansion. Proceedings of the National Academy of Sciences of the United States of America. 106: 1427-32. PMID 19164755 DOI: 10.1073/Pnas.0811848106  0.784
2009 Dubrovska A, Kim S, Salamone RJ, Walker JR, Maira SM, García-Echeverría C, Schultz PG, Reddy VA. The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. Proceedings of the National Academy of Sciences of the United States of America. 106: 268-73. PMID 19116269 DOI: 10.1073/Pnas.0810956106  0.604
2009 Lee J, Hong J, Nam TG, Peters EC, Orth AP, Geierstanger BH, Goldfinger LE, Ginsberg MH, Cho CY, Schultz PG. A small molecule inhibitor of alpha4 integrin-dependent cell migration. Bioorganic & Medicinal Chemistry. 17: 977-80. PMID 18329275 DOI: 10.1016/J.Bmc.2008.02.067  0.783
2009 Wang W, Walker JR, Wang X, Tremblay MS, Lee JW, Wu X, Schultz PG. Erratum: Identification of small-molecule inducers of pancreatic β-cell expansion (Proceedings of the National Academy of Sciences of the United States of America (2009) 106 (1427-1432)) Proceedings of the National Academy of Sciences of the United States of America. 106. DOI: 10.1073/Pnas.0901524106  0.639
2008 Brustad EM, Lemke EA, Schultz PG, Deniz AA. A general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer. Journal of the American Chemical Society. 130: 17664-5. PMID 19108697 DOI: 10.1021/Ja807430H  0.8
2008 Hirota T, Lewis WG, Liu AC, Lee JW, Schultz PG, Kay SA. A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. Proceedings of the National Academy of Sciences of the United States of America. 105: 20746-51. PMID 19104043 DOI: 10.1073/Pnas.0811410106  0.705
2008 Liu CC, Mack AV, Tsao ML, Mills JH, Lee HS, Choe H, Farzan M, Schultz PG, Smider VV. Protein evolution with an expanded genetic code. Proceedings of the National Academy of Sciences of the United States of America. 105: 17688-93. PMID 19004806 DOI: 10.1073/Pnas.0809543105  0.81
2008 Brustad E, Bushey ML, Brock A, Chittuluru J, Schultz PG. A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins. Bioorganic & Medicinal Chemistry Letters. 18: 6004-6. PMID 18845434 DOI: 10.1016/J.Bmcl.2008.09.050  0.802
2008 Brustad E, Bushey ML, Lee JW, Groff D, Liu W, Schultz PG. A genetically encoded boronate-containing amino acid. Angewandte Chemie (International Ed. in English). 47: 8220-3. PMID 18816552 DOI: 10.1002/anie.200803240  0.789
2008 Hyun SL, Schultz PG. Biosynthesis of a site-specific DNA cleaving protein Journal of the American Chemical Society. 130: 13194-13195. PMID 18788806 DOI: 10.1021/Ja804653F  0.341
2008 Grünewald J, Tsao ML, Perera R, Dong L, Niessen F, Wen BG, Kubitz DM, Smider VV, Ruf W, Nasoff M, Lerner RA, Schultz PG. Immunochemical termination of self-tolerance. Proceedings of the National Academy of Sciences of the United States of America. 105: 11276-80. PMID 18685087 DOI: 10.1073/Pnas.0804157105  0.798
2008 Guo J, Wang J, Lee JS, Schultz PG. Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteins. Angewandte Chemie (International Ed. in English). 47: 6399-401. PMID 18624319 DOI: 10.1002/Anie.200802336  0.785
2008 Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, Nagle A, Adrián F, Matzen JT, Anderson P, Nam TG, Gray NS, Chatterjee A, Janes J, Yan SF, ... ... Schultz PG, et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proceedings of the National Academy of Sciences of the United States of America. 105: 9059-64. PMID 18579783 DOI: 10.1073/Pnas.0802982105  0.791
2008 Cellitti SE, Jones DH, Lagpacan L, Hao X, Zhang Q, Hu H, Brittain SM, Brinker A, Caldwell J, Bursulaya B, Spraggon G, Brock A, Ryu Y, Uno T, Schultz PG, et al. In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy Journal of the American Chemical Society. 130: 9268-9281. PMID 18576636 DOI: 10.1021/Ja801602Q  0.808
2008 Kato N, Sakata T, Breton G, Le Roch KG, Nagle A, Andersen C, Bursulaya B, Henson K, Johnson J, Kumar KA, Marr F, Mason D, McNamara C, Plouffe D, Ramachandran V, ... ... Schultz PG, et al. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nature Chemical Biology. 4: 347-56. PMID 18454143 DOI: 10.1038/Nchembio.87  0.78
2008 Debler EW, Kaufmann GF, Meijler MM, Heine A, Mee JM, Pljevaljcic G, Di Bilio AJ, Schultz PG, Millar DP, Janda KD, Wilson IA, Gray HB, Lerner RA. Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. Science (New York, N.Y.). 319: 1232-5. PMID 18309081 DOI: 10.1126/Science.1153445  0.464
2008 Guo J, Wang J, Anderson JC, Schultz PG. Addition of an alpha-hydroxy acid to the genetic code of bacteria. Angewandte Chemie (International Ed. in English). 47: 722-5. PMID 18069708 DOI: 10.1002/Anie.200704074  0.774
2008 Graziano JJ, Liu W, Perera R, Geierstanger BH, Lesley SA, Schultz PG. Selecting folded proteins from a library of secondary structural elements. Journal of the American Chemical Society. 130: 176-85. PMID 18067292 DOI: 10.1021/Ja074405W  0.802
2008 Supekova L, Supek F, Lee J, Chen S, Gray N, Pezacki JP, Schlapbach A, Schultz PG. Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening. The Journal of Biological Chemistry. 283: 29-36. PMID 17951261 DOI: 10.1074/Jbc.M703988200  0.774
2008 Boitano AE, Schultz PG, Cooke M. Self-Renewal of Hematopoietic Stem Cells by a Small Molecule Blood. 112: 210-210. DOI: 10.1182/Blood.V112.11.210.210  0.301
2007 Tippmann EM, Liu W, Summerer D, Mack AV, Schultz PG. A genetically encoded diazirine photocrosslinker in Escherichia coli. Chembiochem : a European Journal of Chemical Biology. 8: 2210-4. PMID 18000916 DOI: 10.1002/Cbic.200700460  0.659
2007 Seyedsayamdost MR, Xie J, Chan CT, Schultz PG, Stubbe J. Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation. Journal of the American Chemical Society. 129: 15060-71. PMID 17990884 DOI: 10.1021/Ja076043Y  0.588
2007 Lemke EA, Summerer D, Geierstanger BH, Brittain SM, Schultz PG. Control of protein phosphorylation with a genetically encoded photocaged amino acid Nature Chemical Biology. 3: 769-772. PMID 17965709 DOI: 10.1038/Nchembio.2007.44  0.738
2007 Xie J, Liu W, Schultz PG. A genetically encoded bidentate, metal-binding amino acid. Angewandte Chemie (International Ed. in English). 46: 9239-42. PMID 17893898 DOI: 10.1002/Anie.200703397  0.586
2007 Lee J, Wu X, Pasca di Magliano M, Peters EC, Wang Y, Hong J, Hebrok M, Ding S, Cho CY, Schultz PG. A small-molecule antagonist of the hedgehog signaling pathway. Chembiochem : a European Journal of Chemical Biology. 8: 1916-9. PMID 17886323 DOI: 10.1002/Cbic.200700403  0.768
2007 Lyssiotis CA, Walker J, Wu C, Kondo T, Schultz PG, Wu X. Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells Proceedings of the National Academy of Sciences of the United States of America. 104: 14982-14987. PMID 17855562 DOI: 10.1073/Pnas.0707044104  0.699
2007 Liu CC, Brustad E, Liu W, Schultz PG. Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin. Journal of the American Chemical Society. 129: 10648-9. PMID 17685615 DOI: 10.1021/Ja0735002  0.728
2007 Matsuda S, Fillo JD, Henry AA, Rai P, Wilkens SJ, Dwyer TJ, Geierstanger BH, Wemmer DE, Schultz PG, Spraggon G, Romesberg FE. Efforts toward expansion of the genetic alphabet: structure and replication of unnatural base pairs. Journal of the American Chemical Society. 129: 10466-73. PMID 17685517 DOI: 10.1021/Ja072276D  0.781
2007 Wang J, Schiller SM, Schultz PG. A biosynthetic route to dehydroalanine-containing proteins. Angewandte Chemie (International Ed. in English). 46: 6849-51. PMID 17685371 DOI: 10.1002/Anie.200702305  0.784
2007 Dierks C, Grbic J, Zirlik K, Beigi R, Englund NP, Guo GR, Veelken H, Engelhardt M, Mertelsmann R, Kelleher JF, Schultz P, Warmuth M. Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nature Medicine. 13: 944-51. PMID 17632527 DOI: 10.1038/Nm1614  0.783
2007 Liu W, Alfonta L, Mack AV, Schultz PG. Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases. Angewandte Chemie (International Ed. in English). 46: 6073-5. PMID 17628477 DOI: 10.1002/Anie.200701990  0.661
2007 Xie J, Supekova L, Schultz PG. A genetically encoded metabolically stable analogue of phosphotyrosine in Escherichia coli. Acs Chemical Biology. 2: 474-8. PMID 17622177 DOI: 10.1021/Cb700083W  0.804
2007 Trisler K, Looger LL, Sharma V, Baker M, Benson DE, Trauger S, Schultz PG, Smider VV. A metalloantibody that irreversibly binds a protein antigen. The Journal of Biological Chemistry. 282: 26344-53. PMID 17617633 DOI: 10.1074/Jbc.M704675200  0.672
2007 Chen S, Takanashi S, Zhang Q, Xiong W, Zhu S, Peters EC, Ding S, Schultz PG. Reversine increases the plasticity of lineage-committed mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 10482-7. PMID 17566101 DOI: 10.1073/Pnas.0704360104  0.794
2007 Chen S, Schultz PG, Brock A. An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae. Journal of Molecular Biology. 371: 112-22. PMID 17560600 DOI: 10.1016/J.Jmb.2007.05.017  0.806
2007 Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg MH, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S. Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 7444-8. PMID 17460038 DOI: 10.1073/Pnas.0702136104  0.779
2007 Gumireddy K, Sun F, Klein-Szanto AJ, Gibbins JM, Gimotty PA, Saunders AJ, Schultz PG, Huang Q. In vivo selection for metastasis promoting genes in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 104: 6696-701. PMID 17420453 DOI: 10.1073/Pnas.0701145104  0.47
2007 Liu Y, Kern JT, Walker JR, Johnson JA, Schultz PG, Luesch H. A genomic screen for activators of the antioxidant response element. Proceedings of the National Academy of Sciences of the United States of America. 104: 5205-10. PMID 17360324 DOI: 10.1073/Pnas.0700898104  0.666
2007 Hong J, Lee J, Min KH, Walker JR, Peters EC, Gray NS, Cho CY, Schultz PG. Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation. Acs Chemical Biology. 2: 171-5. PMID 17348628 DOI: 10.1021/Cb600435T  0.788
2007 Liu W, Brock A, Chen S, Chen S, Schultz PG. Genetic incorporation of unnatural amino acids into proteins in mammalian cells. Nature Methods. 4: 239-44. PMID 17322890 DOI: 10.1038/nmeth1016  0.814
2007 Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, Patapoutian A. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature. 445: 541-5. PMID 17237762 DOI: 10.1038/Nature05544  0.779
2007 Galkin AV, Melnick JS, Kim S, Hood TL, Li N, Li L, Xia G, Steensma R, Chopiuk G, Jiang J, Wan Y, Ding P, Liu Y, Sun F, Schultz PG, et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proceedings of the National Academy of Sciences of the United States of America. 104: 270-5. PMID 17185414 DOI: 10.1073/Pnas.0609412103  0.792
2007 Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg MH, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S. Erratum: Small-molecule synergist of the Wnt/β-catenin signaling pathway (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, 18, (7444-7448) DOI: 10.1073/pnas.0702136104) Proceedings of the National Academy of Sciences of the United States of America. 104. DOI: 10.1073/Pnas.0705165104  0.76
2007 Tippmann EM, Schultz PG. A genetically encoded metallocene containing amino acid Tetrahedron. 63: 6182-6184. DOI: 10.1016/J.Tet.2007.02.125  0.371
2007 Liu DR, Schultz PG. Generating New Molecular Function: A Lesson from Nature Essays in Contemporary Chemistry: From Molecular Structure Towards Biology. 341-379. DOI: 10.1002/(Sici)1521-3773(19990115)38:1/2<36::Aid-Anie36>3.0.Co;2-I  0.463
2006 Mukherji M, Brill LM, Ficarro SB, Hampton GM, Schultz PG. A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways. Biochemistry. 45: 15529-40. PMID 17176074 DOI: 10.1021/Bi060971C  0.334
2006 Tian F, Debler EW, Millar DP, Deniz AA, Wilson IA, Schultz PG. The effects of antibodies on stilbene excited-state energetics. Angewandte Chemie (International Ed. in English). 45: 7763-5. PMID 17089439 DOI: 10.1002/Anie.200602720  0.645
2006 Chen S, Do JT, Zhang Q, Yao S, Yan F, Peters EC, Schöler HR, Schultz PG, Ding S. Self-renewal of embryonic stem cells by a small molecule. Proceedings of the National Academy of Sciences of the United States of America. 103: 17266-71. PMID 17088537 DOI: 10.1073/Pnas.0608156103  0.79
2006 Liu CC, Schultz PG. Recombinant expression of selectively sulfated proteins in Escherichia coli Nature Biotechnology. 24: 1436-1440. PMID 17072302 DOI: 10.1038/Nbt1254  0.434
2006 Schultz KC, Supekova L, Ryu Y, Xie J, Perera R, Schultz PG. A genetically encoded infrared probe. Journal of the American Chemical Society. 128: 13984-5. PMID 17061854 DOI: 10.1021/Ja0636690  0.799
2006 Mukherji M, Bell R, Supekova L, Wang Y, Orth AP, Batalov S, Miraglia L, Huesken D, Lange J, Martin C, Sahasrabudhe S, Reinhardt M, Natt F, Hall J, Mickanin C, ... ... Schultz PG, et al. Genome-wide functional analysis of human cell-cycle regulators. Proceedings of the National Academy of Sciences of the United States of America. 103: 14819-24. PMID 17001007 DOI: 10.1073/Pnas.0604320103  0.788
2006 Zeng H, Xie J, Schultz PG. Genetic introduction of a diketone-containing amino acid into proteins. Bioorganic & Medicinal Chemistry Letters. 16: 5356-9. PMID 16934461 DOI: 10.1016/J.Bmcl.2006.07.094  0.715
2006 Xie J, Schultz PG. A chemical toolkit for proteins--an expanded genetic code. Nature Reviews. Molecular Cell Biology. 7: 775-82. PMID 16926858 DOI: 10.1038/Nrm2005  0.539
2006 Wang J, Xie J, Schultz PG. A genetically encoded fluorescent amino acid. Journal of the American Chemical Society. 128: 8738-9. PMID 16819861 DOI: 10.1021/Ja062666K  0.799
2006 Summerer D, Chen S, Wu N, Deiters A, Chin JW, Schultz PG. A genetically encoded fluorescent amino acid. Proceedings of the National Academy of Sciences of the United States of America. 103: 9785-9. PMID 16785423 DOI: 10.1073/Pnas.0603965103  0.81
2006 Wang L, Xie J, Schultz PG. Expanding the genetic code. Annual Review of Biophysics and Biomolecular Structure. 35: 225-49. PMID 16689635 DOI: 10.1146/Annurev.Biophys.35.101105.121507  0.568
2006 Berezhna SY, Supekova L, Supek F, Schultz PG, Deniz AA. siRNA in human cells selectively localizes to target RNA sites. Proceedings of the National Academy of Sciences of the United States of America. 103: 7682-7. PMID 16684885 DOI: 10.1073/Pnas.0600148103  0.776
2006 Cho CY, Koo SH, Wang Y, Callaway S, Hedrick S, Mak PA, Orth AP, Peters EC, Saez E, Montminy M, Schultz PG, Chanda SK. Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. Cell Metabolism. 3: 367-78. PMID 16679294 DOI: 10.1016/J.Cmet.2006.03.006  0.729
2006 Turner JM, Graziano J, Spraggon G, Schultz PG. Structural plasticity of an aminoacyl-tRNA synthetase active site. Proceedings of the National Academy of Sciences of the United States of America. 103: 6483-8. PMID 16618920 DOI: 10.1073/Pnas.0601756103  0.802
2006 Tsao ML, Summerer D, Ryu Y, Schultz PG. The genetic incorporation of a distance probe into proteins in Escherichia coli. Journal of the American Chemical Society. 128: 4572-3. PMID 16594684 DOI: 10.1021/Ja058262U  0.804
2006 Ryu Y, Schultz PG. Efficient incorporation of unnatural amino acids into proteins in Escherichia coli. Nature Methods. 3: 263-5. PMID 16554830 DOI: 10.1038/Nmeth864  0.622
2006 Deiters A, Groff D, Ryu Y, Xie J, Schultz PG. A genetically encoded photocaged tyrosine. Angewandte Chemie (International Ed. in English). 45: 2728-31. PMID 16548032 DOI: 10.1002/Anie.200600264  0.77
2006 Collins CS, Hong J, Sapinoso L, Zhou Y, Liu Z, Micklash K, Schultz PG, Hampton GM. A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. Proceedings of the National Academy of Sciences of the United States of America. 103: 3775-80. PMID 16537454 DOI: 10.1073/Pnas.0600040103  0.551
2006 Melnick JS, Janes J, Kim S, Chang JY, Sipes DG, Gunderson D, Jarnes L, Matzen JT, Garcia ME, Hood TL, Beigi R, Xia G, Harig RA, Asatryan H, Yan SF, ... ... Schultz PG, et al. An efficient rapid system for profiling the cellular activities of molecular libraries. Proceedings of the National Academy of Sciences of the United States of America. 103: 3153-8. PMID 16492761 DOI: 10.1073/Pnas.0511292103  0.798
2006 Luesch H, Chanda SK, Raya RM, DeJesus PD, Orth AP, Walker JR, Izpisúa Belmonte JC, Schultz PG. A functional genomics approach to the mode of action of apratoxin A. Nature Chemical Biology. 2: 158-67. PMID 16474387 DOI: 10.1038/Nchembio769  0.737
2006 Sagan SM, Rouleau Y, Leggiadro C, Supekova L, Schultz PG, Su AI, Pezacki JP. The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 84: 67-79. PMID 16462891 DOI: 10.1139/O05-149  0.769
2006 Saraf-Levy T, Santoro SW, Volpin H, Kushnirsky T, Eyal Y, Schultz PG, Gidoni D, Carmi N. Site-specific recombination of asymmetric lox sites mediated by a heterotetrameric Cre recombinase complex. Bioorganic & Medicinal Chemistry. 14: 3081-9. PMID 16412655 DOI: 10.1016/J.Bmc.2005.12.016  0.789
2006 Bose M, Groff D, Xie J, Brustad E, Schultz PG. The incorporation of a photoisomerizable amino acid into proteins in E. coli. Journal of the American Chemical Society. 128: 388-9. PMID 16402807 DOI: 10.1021/Ja055467U  0.807
2006 Lowery TJ, Garcia S, Chavez L, Ruiz EJ, Wu T, Brotin T, Dutasta JP, King DS, Schultz PG, Pines A, Wemmer DE. Optimization of xenon biosensors for detection of protein interactions. Chembiochem : a European Journal of Chemical Biology. 7: 65-73. PMID 16342304 DOI: 10.1002/Cbic.200500327  0.629
2006 Warashina M, Min KH, Kuwabara T, Huynh A, Gage FH, Schultz PG, Ding S. A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angewandte Chemie (International Ed. in English). 45: 591-3. PMID 16323231 DOI: 10.1002/Anie.200503089  0.741
2005 Tsao ML, Tian F, Schultz PG. Selective Staudinger modification of proteins containing p-azidophenylalanine. Chembiochem : a European Journal of Chemical Biology. 6: 2147-9. PMID 16317766 DOI: 10.1002/Cbic.200500314  0.749
2005 Xie J, Schultz PG. Adding amino acids to the genetic repertoire. Current Opinion in Chemical Biology. 9: 548-54. PMID 16260173 DOI: 10.1016/J.Cbpa.2005.10.011  0.537
2005 Turner JM, Graziano J, Spraggon G, Schultz PG. Structural characterization of a p-acetylphenylalanyl aminoacyl-tRNA synthetase. Journal of the American Chemical Society. 127: 14976-7. PMID 16248607 DOI: 10.1021/Ja0549042  0.798
2005 Willingham AT, Orth AP, Batalov S, Peters EC, Wen BG, Aza-Blanc P, Hogenesch JB, Schultz PG. A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Science (New York, N.Y.). 309: 1570-3. PMID 16141075 DOI: 10.1126/Science.1115901  0.788
2005 Xie J, Schultz PG. An expanding genetic code. Methods (San Diego, Calif.). 36: 227-38. PMID 16076448 DOI: 10.1016/J.Ymeth.2005.04.010  0.544
2005 Ding S, Schultz PG. Small molecules and future regenerative medicine. Current Topics in Medicinal Chemistry. 5: 383-95. PMID 15892681 DOI: 10.2174/1568026053828402  0.639
2005 Zhang Y, Wang L, Schultz PG, Wilson IA. Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine. Protein Science : a Publication of the Protein Society. 14: 1340-9. PMID 15840835 DOI: 10.1110/Ps.041239305  0.37
2005 Liu J, Wu X, Mitchell B, Kintner C, Ding S, Schultz PG. A small-molecule agonist of the Wnt signaling pathway. Angewandte Chemie (International Ed. in English). 44: 1987-90. PMID 15724259 DOI: 10.1002/Anie.200462552  0.693
2005 Deiters A, Schultz PG. In vivo incorporation of an alkyne into proteins in Escherichia coli. Bioorganic & Medicinal Chemistry Letters. 15: 1521-4. PMID 15713420 DOI: 10.1016/J.Bmcl.2004.12.065  0.678
2005 Liu J, Bang AG, Kintner C, Orth AP, Chanda SK, Ding S, Schultz PG. Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis. Proceedings of the National Academy of Sciences of the United States of America. 102: 1927-32. PMID 15677333 DOI: 10.1073/Pnas.0409472102  0.785
2005 Luesch H, Wu TY, Ren P, Gray NS, Schultz PG, Supek F. A genome-wide overexpression screen in yeast for small-molecule target identification. Chemistry & Biology. 12: 55-63. PMID 15664515 DOI: 10.1016/J.Chembiol.2004.10.015  0.707
2005 Deiters A, Geierstanger BH, Schultz PG. Site-specific in vivo labeling of proteins for NMR studies. Chembiochem : a European Journal of Chemical Biology. 6: 55-8. PMID 15549724 DOI: 10.1002/Cbic.200400319  0.668
2004 Venkateshrao S, Yin J, Jarzecki AA, Schultz PG, Spiro TG. Porphyrin distortion during affinity maturation of a ferrochelatase antibody, monitored by Resonance Raman spectroscopy. Journal of the American Chemical Society. 126: 16361-7. PMID 15600337 DOI: 10.1021/Ja0465395  0.489
2004 Wang L, Schultz PG. Expanding the genetic code. Angewandte Chemie (International Ed. in English). 44: 34-66. PMID 15599909 DOI: 10.1002/Anie.200460627  0.393
2004 Tian F, Tsao ML, Schultz PG. A phage display system with unnatural amino acids. Journal of the American Chemical Society. 126: 15962-3. PMID 15584720 DOI: 10.1021/Ja045673M  0.77
2004 Xu R, Hanson SR, Zhang Z, Yang YY, Schultz PG, Wong CH. Site-specific incorporation of the mucin-type N-acetylgalactosamine-alpha-O-threonine into protein in Escherichia coli. Journal of the American Chemical Society. 126: 15654-5. PMID 15571382 DOI: 10.1021/ja044711z  0.587
2004 Spence MM, Ruiz EJ, Rubin SM, Lowery TJ, Winssinger N, Schultz PG, Wemmer DE, Pines A. Development of a functionalized xenon biosensor. Journal of the American Chemical Society. 126: 15287-94. PMID 15548026 DOI: 10.1021/Ja0483037  0.716
2004 Cropp TA, Schultz PG. An expanding genetic code. Trends in Genetics : Tig. 20: 625-30. PMID 15522458 DOI: 10.1016/J.Tig.2004.09.013  0.354
2004 Wu N, Deiters A, Cropp TA, King D, Schultz PG. A genetically encoded photocaged amino acid. Journal of the American Chemical Society. 126: 14306-7. PMID 15521721 DOI: 10.1021/Ja040175Z  0.727
2004 Deiters A, Cropp TA, Summerer D, Mukherji M, Schultz PG. Site-specific PEGylation of proteins containing unnatural amino acids. Bioorganic & Medicinal Chemistry Letters. 14: 5743-5. PMID 15501033 DOI: 10.1016/J.Bmcl.2004.09.059  0.781
2004 Wu X, Walker J, Zhang J, Ding S, Schultz PG. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chemistry & Biology. 11: 1229-38. PMID 15380183 DOI: 10.1016/J.Chembiol.2004.06.010  0.683
2004 Xie J, Wang L, Wu N, Brock A, Spraggon G, Schultz PG. The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination. Nature Biotechnology. 22: 1297-301. PMID 15378068 DOI: 10.1038/Nbt1013  0.629
2004 Ding S, Schultz PG. A role for chemistry in stem cell biology. Nature Biotechnology. 22: 833-40. PMID 15229546 DOI: 10.1038/Nbt987  0.625
2004 Williams B, Watanabe CM, Schultz PG, Rimbach G, Krucker T. Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability. Neurobiology of Aging. 25: 955-62. PMID 15212849 DOI: 10.1016/J.Neurobiolaging.2003.10.008  0.66
2004 Torres FE, Kuhn P, De Bruyker D, Bell AG, Wolkin MV, Peeters E, Williamson JR, Anderson GB, Schmitz GP, Recht MI, Schweizer S, Scott LG, Ho JH, Elrod SA, Schultz PG, et al. Enthalpy arrays. Proceedings of the National Academy of Sciences of the United States of America. 101: 9517-22. PMID 15210951 DOI: 10.1073/Pnas.0403573101  0.477
2004 Schlieker C, Weibezahn J, Patzelt H, Tessarz P, Strub C, Zeth K, Erbse A, Schneider-Mergener J, Chin JW, Schultz PG, Bukau B, Mogk A. Substrate recognition by the AAA+ chaperone ClpB. Nature Structural & Molecular Biology. 11: 607-15. PMID 15208691 DOI: 10.1038/Nsmb787  0.551
2004 Zhang Z, Alfonta L, Tian F, Bursulaya B, Uryu S, King DS, Schultz PG. Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 8882-7. PMID 15187228 DOI: 10.1073/pnas.0307029101  0.683
2004 Anderson JC, Wu N, Santoro SW, Lakshman V, King DS, Schultz PG. An expanded genetic code with a functional quadruplet codon. Proceedings of the National Academy of Sciences of the United States of America. 101: 7566-71. PMID 15138302 DOI: 10.1073/Pnas.0401517101  0.805
2004 Wignall SM, Gray NS, Chang YT, Juarez L, Jacob R, Burlingame A, Schultz PG, Heald R. Identification of a novel protein regulating microtubule stability through a chemical approach. Chemistry & Biology. 11: 135-46. PMID 15113003 DOI: 10.1016/J.Chembiol.2003.12.019  0.591
2004 Yin J, Mills JH, Schultz PG. A catalysis-based selection for peroxidase antibodies with increased activity. Journal of the American Chemical Society. 126: 3006-7. PMID 15012103 DOI: 10.1021/Ja039198O  0.726
2004 Huang Q, Raya A, DeJesus P, Chao SH, Quon KC, Caldwell JS, Chanda SK, Izpisua-Belmonte JC, Schultz PG. Identification of p53 regulators by genome-wide functional analysis. Proceedings of the National Academy of Sciences of the United States of America. 101: 3456-61. PMID 14990790 DOI: 10.1073/Pnas.0308562100  0.467
2004 Wu X, Ding S, Ding Q, Gray NS, Schultz PG. Small molecules that induce cardiomyogenesis in embryonic stem cells. Journal of the American Chemical Society. 126: 1590-1. PMID 14871063 DOI: 10.1021/Ja038950I  0.715
2004 Zhang Z, Gildersleeve J, Yang YY, Xu R, Loo JA, Uryu S, Wong CH, Schultz PG. A new strategy for the synthesis of glycoproteins. Science (New York, N.Y.). 303: 371-3. PMID 14726590 DOI: 10.1126/Science.1089509  0.661
2004 Chen S, Zhang Q, Wu X, Schultz PG, Ding S. Dedifferentiation of lineage-committed cells by a small molecule. Journal of the American Chemical Society. 126: 410-1. PMID 14719906 DOI: 10.1021/Ja037390K  0.791
2004 Zimmermann N, Meggers E, Schultz PG. A second-generation copper(II)-mediated metallo-DNA-base pair. Bioorganic Chemistry. 32: 13-25. PMID 14700559 DOI: 10.1016/J.Bioorg.2003.09.001  0.514
2004 Wu TY, Hassig C, Wu Y, Ding S, Schultz PG. Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group. Bioorganic & Medicinal Chemistry Letters. 14: 449-53. PMID 14698179 DOI: 10.1016/J.Bmcl.2003.10.055  0.789
2004 Zheng L, Liu J, Batalov S, Zhou D, Orth A, Ding S, Schultz PG. An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 135-40. PMID 14688408 DOI: 10.1073/Pnas.2136685100  0.789
2003 Lowery TJ, Rubin SM, Ruiz EJ, Spence MM, Winssinger N, Schultz PG, Pines A, Wemmer DE. Applications of laser-polarized 129Xe to biomolecular assays. Magnetic Resonance Imaging. 21: 1235-9. PMID 14725931 DOI: 10.1016/J.Mri.2003.08.025  0.707
2003 Gildersleeve J, Varvak A, Atwell S, Evans D, Schultz PG. Development of a high-throughput screen for protein catalysts: application to the directed evolution of antibody aldolases. Angewandte Chemie (International Ed. in English). 42: 5971-3. PMID 14679545 DOI: 10.1002/Anie.200352117  0.786
2003 Baldwin EP, Martin SS, Abel J, Gelato KA, Kim H, Schultz PG, Santoro SW. A specificity switch in selected cre recombinase variants is mediated by macromolecular plasticity and water. Chemistry & Biology. 10: 1085-94. PMID 14652076 DOI: 10.1016/J.Chembiol.2003.10.015  0.785
2003 Alfonta L, Zhang Z, Uryu S, Loo JA, Schultz PG. Site-specific incorporation of a redox-active amino acid into proteins. Journal of the American Chemical Society. 125: 14662-3. PMID 14640614 DOI: 10.1021/Ja038242X  0.662
2003 Santoro SW, Anderson JC, Lakshman V, Schultz PG. An archaebacteria-derived glutamyl-tRNA synthetase and tRNA pair for unnatural amino acid mutagenesis of proteins in Escherichia coli. Nucleic Acids Research. 31: 6700-9. PMID 14627803 DOI: 10.1093/Nar/Gkg903  0.804
2003 Esaki M, Kanamori T, Nishikawa S, Shin I, Schultz PG, Endo T. Tom40 protein import channel binds to non-native proteins and prevents their aggregation. Nature Structural Biology. 10: 988-94. PMID 14595396 DOI: 10.1038/Nsb1008  0.521
2003 Chanda SK, White S, Orth AP, Reisdorph R, Miraglia L, Thomas RS, DeJesus P, Mason DE, Huang Q, Vega R, Yu DH, Nelson CG, Smith BM, Terry R, Linford AS, ... ... Schultz PG, et al. Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 100: 12153-8. PMID 14514886 DOI: 10.1073/Pnas.1934839100  0.783
2003 Wu TY, Schultz PG, Ding S. One-pot two-step microwave-assisted reaction in constructing 4,5-disubstituted pyrazolopyrimidines. Organic Letters. 5: 3587-90. PMID 14507179 DOI: 10.1021/Ol035226W  0.667
2003 Deiters A, Cropp TA, Mukherji M, Chin JW, Anderson JC, Schultz PG. Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae. Journal of the American Chemical Society. 125: 11782-3. PMID 14505376 DOI: 10.1021/Ja0370037  0.801
2003 Li S, Cutler G, Liu JJ, Hoey T, Chen L, Schultz PG, Liao J, Ling XB. A comparative analysis of HGSC and Celera human genome assemblies and gene sets. Bioinformatics (Oxford, England). 19: 1597-605. PMID 12967954 DOI: 10.1093/Bioinformatics/Btg219  0.767
2003 Wu TY, Wagner KW, Bursulaya B, Schultz PG, Deveraux QL. Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction. Chemistry & Biology. 10: 759-67. PMID 12954335 DOI: 10.1016/S1074-5521(03)00157-1  0.525
2003 Chin JW, Cropp TA, Anderson JC, Mukherji M, Zhang Z, Schultz PG. An expanded eukaryotic genetic code. Science (New York, N.Y.). 301: 964-7. PMID 12920298 DOI: 10.1126/Science.1084772  0.678
2003 Anderson JC, Schultz PG. Adaptation of an orthogonal archaeal leucyl-tRNA and synthetase pair for four-base, amber, and opal suppression. Biochemistry. 42: 9598-608. PMID 12911301 DOI: 10.1021/Bi034550W  0.558
2003 Mirotsou M, Watanabe CM, Schultz PG, Pratt RE, Dzau VJ. Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach. Physiological Genomics. 15: 115-26. PMID 12902547 DOI: 10.1152/Physiolgenomics.00071.2003  0.673
2003 Liao J, Schultz PG. Three sweet receptor genes are clustered in human chromosome 1. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 14: 291-301. PMID 12856281 DOI: 10.1007/S00335-002-2233-0  0.536
2003 Yin J, Beuscher AE, Andryski SE, Stevens RC, Schultz PG. Structural plasticity and the evolution of antibody affinity and specificity. Journal of Molecular Biology. 330: 651-6. PMID 12850137 DOI: 10.1016/S0022-2836(03)00631-4  0.612
2003 Chin JW, Cropp TA, Chu S, Meggers E, Schultz PG. Progress toward an expanded eukaryotic genetic code. Chemistry & Biology. 10: 511-9. PMID 12837384 DOI: 10.1016/S1074-5521(03)00123-6  0.704
2003 Santoro SW, Schultz PG. Directed evolution of the substrate specificities of a site-specific recombinase and an aminoacyl-tRNA synthetase using fluorescence-activated cell sorting (FACS). Methods in Molecular Biology (Clifton, N.J.). 230: 291-312. PMID 12824591 DOI: 10.1385/1-59259-396-8:291  0.789
2003 Ding S, Wu TY, Brinker A, Peters EC, Hur W, Gray NS, Schultz PG. Synthetic small molecules that control stem cell fate. Proceedings of the National Academy of Sciences of the United States of America. 100: 7632-7. PMID 12794184 DOI: 10.1073/Pnas.0732087100  0.788
2003 Matsuda S, Henry AA, Schultz PG, Romesberg FE. The effect of minor-groove hydrogen-bond acceptors and donors on the stability and replication of four unnatural base pairs. Journal of the American Chemical Society. 125: 6134-9. PMID 12785844 DOI: 10.1021/Ja034099W  0.781
2003 Zhang Z, Smith BA, Wang L, Brock A, Cho C, Schultz PG. A new strategy for the site-specific modification of proteins in vivo. Biochemistry. 42: 6735-46. PMID 12779328 DOI: 10.1021/Bi0300231  0.649
2003 Licht SS, Sonnleitner A, Weiss S, Schultz PG. A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis. Biochemistry. 42: 2916-25. PMID 12627957 DOI: 10.1021/Bi026059V  0.499
2003 Liu H, Wang L, Brock A, Wong CH, Schultz PG. A method for the generation of glycoprotein mimetics. Journal of the American Chemical Society. 125: 1702-3. PMID 12580587 DOI: 10.1021/Ja029433N  0.391
2003 Yin J, Andryski SE, Beuscher AE, Stevens RC, Schultz PG. Structural evidence for substrate strain in antibody catalysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 856-61. PMID 12552112 DOI: 10.1073/Pnas.0235873100  0.597
2003 Mehl RA, Anderson JC, Santoro SW, Wang L, Martin AB, King DS, Horn DM, Schultz PG. Generation of a bacterium with a 21 amino acid genetic code. Journal of the American Chemical Society. 125: 935-9. PMID 12537491 DOI: 10.1021/Ja0284153  0.798
2003 Lin Q, Barbas CF, Schultz PG. Small-molecule switches for zinc finger transcription factors. Journal of the American Chemical Society. 125: 612-3. PMID 12526643 DOI: 10.1021/Ja028408E  0.554
2003 Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC. Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 100: 443-8. PMID 12522270 DOI: 10.1073/Pnas.2436191100  0.797
2003 Wang L, Zhang Z, Brock A, Schultz PG. Addition of the keto functional group to the genetic code of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 100: 56-61. PMID 12518054 DOI: 10.1073/Pnas.0234824100  0.416
2003 Wang L, Xie J, Deniz AA, Schultz PG. Unnatural amino acid mutagenesis of green fluorescent protein. The Journal of Organic Chemistry. 68: 174-6. PMID 12515477 DOI: 10.1021/Jo026570U  0.697
2003 Wieland SF, Vega RG, Müller R, Evans CF, Hilbush B, Guidotti LG, Sutcliffe JG, Schultz PG, Chisari FV. Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes. Journal of Virology. 77: 1227-36. PMID 12502840 DOI: 10.1128/Jvi.77.2.1227-1236.2003  0.497
2002 Wu Y, Fa M, Tae EL, Schultz PG, Romesberg FE. Enzymatic phosphorylation of unnatural nucleosides. Journal of the American Chemical Society. 124: 14626-30. PMID 12465973 DOI: 10.1021/Ja028050M  0.783
2002 Chapman E, Ding S, Schultz PG, Wong CH. A potent and highly selective sulfotransferase inhibitor. Journal of the American Chemical Society. 124: 14524-5. PMID 12465948 DOI: 10.1021/Ja021086U  0.699
2002 Wu X, Ding S, Ding Q, Gray NS, Schultz PG. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Journal of the American Chemical Society. 124: 14520-1. PMID 12465946 DOI: 10.1021/Ja0283908  0.717
2002 Schultz PG, Yin J, Lerner RA. The chemistry of the antibody molecule. Angewandte Chemie (International Ed. in English). 41: 4427-37. PMID 12458503 DOI: 10.1002/1521-3773(20021202)41:23<4427::Aid-Anie4427>3.0.Co;2-K  0.615
2002 Su AI, Pezacki JP, Wodicka L, Brideau AD, Supekova L, Thimme R, Wieland S, Bukh J, Purcell RH, Schultz PG, Chisari FV. Genomic analysis of the host response to hepatitis C virus infection. Proceedings of the National Academy of Sciences of the United States of America. 99: 15669-74. PMID 12441396 DOI: 10.1073/Pnas.202608199  0.765
2002 Zimmermann N, Meggers E, Schultz PG. A novel silver(i)-mediated DNA base pair. Journal of the American Chemical Society. 124: 13684-5. PMID 12431092 DOI: 10.1021/Ja0279951  0.513
2002 Wu TY, Schultz PG. A versatile linkage strategy for solid-phase synthesis of N,N-dimethyltryptamines and beta-carbolines. Organic Letters. 4: 4033-6. PMID 12423079 DOI: 10.1021/Ol026729P  0.462
2002 Chin JW, Schultz PG. In vivo photocrosslinking with unnatural amino Acid mutagenesis. Chembiochem : a European Journal of Chemical Biology. 3: 1135-7. PMID 12404640 DOI: 10.1002/1439-7633(20021104)3:11<1135::Aid-Cbic1135>3.0.Co;2-M  0.553
2002 Yu C, Henry AA, Romesberg FE, Schultz PG. Polymerase recognition of unnatural base pairs. Angewandte Chemie (International Ed. in English). 41: 3841-4. PMID 12386865 DOI: 10.1002/1521-3773(20021018)41:20<3841::Aid-Anie3841>3.0.Co;2-Q  0.765
2002 Damoiseaux R, Schultz PG, Johnsson K. Towards the generation of artificial O6-alkylguanine-DNA alkyltransferases: in vitro selection of antibodies with reactive cysteine residues. Chembiochem : a European Journal of Chemical Biology. 3: 573-5. PMID 12325014 DOI: 10.1002/1439-7633(20020603)3:6<573::Aid-Cbic573>3.0.Co;2-F  0.582
2002 Santoro SW, Wang L, Herberich B, King DS, Schultz PG. An efficient system for the evolution of aminoacyl-tRNA synthetase specificity. Nature Biotechnology. 20: 1044-8. PMID 12244330 DOI: 10.1038/Nbt742  0.82
2002 Knockaert M, Lenormand P, Gray N, Schultz P, Pouysségur J, Meijer L. p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene. 21: 6413-24. PMID 12226745 DOI: 10.1038/Sj.Onc.1205908  0.468
2002 Chang YT, Choi G, Bae YS, Burdett M, Moon HS, Lee JW, Gray NS, Schultz PG, Meijer L, Chung SK, Choi KY, Suh PG, Ryu SH. Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem : a European Journal of Chemical Biology. 3: 897-901. PMID 12210991 DOI: 10.1002/1439-7633(20020902)3:9<897::Aid-Cbic897>3.0.Co;2-B  0.781
2002 Zhang Z, Wang L, Brock A, Schultz PG. The selective incorporation of alkenes into proteins in Escherichia coli. Angewandte Chemie (International Ed. in English). 41: 2840-2. PMID 12203503 DOI: 10.1002/1521-3773(20020802)41:15<2840::AID-ANIE2840>3.0.CO;2-#  0.343
2002 Lesley SA, Kuhn P, Godzik A, Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, ... ... Schultz PG, et al. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proceedings of the National Academy of Sciences of the United States of America. 99: 11664-9. PMID 12193646 DOI: 10.1073/Pnas.142413399  0.627
2002 Su AI, Guidotti LG, Pezacki JP, Chisari FV, Schultz PG. Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 11181-6. PMID 12177410 DOI: 10.1073/Pnas.122359899  0.766
2002 Winssinger N, Ficarro S, Schultz PG, Harris JL. Profiling protein function with small molecule microarrays. Proceedings of the National Academy of Sciences of the United States of America. 99: 11139-44. PMID 12167675 DOI: 10.1073/Pnas.172286899  0.681
2002 Li S, Liao J, Cutler G, Hoey T, Hogenesch JB, Cooke MP, Schultz PG, Ling XB. Comparative analysis of human genome assemblies reveals genome-level differences. Genomics. 80: 138-9. PMID 12160725 DOI: 10.1006/Geno.2002.6824  0.723
2002 Chin JW, Martin AB, King DS, Wang L, Schultz PG. Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli. Proceedings of the National Academy of Sciences of the United States of America. 99: 11020-4. PMID 12154230 DOI: 10.1073/Pnas.172226299  0.67
2002 Schultz PG, Lerner RA. Completing the circle. Nature. 418: 485. PMID 12152057 DOI: 10.1038/418485A  0.474
2002 Chin JW, Santoro SW, Martin AB, King DS, Wang L, Schultz PG. Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. Journal of the American Chemical Society. 124: 9026-7. PMID 12148987 DOI: 10.1021/Ja027007W  0.797
2002 Supekova L, Pezacki JP, Su AI, Loweth CJ, Riedl R, Geierstanger B, Schultz PG, Wemmer DE. Genomic effects of polyamide/DNA interactions on mRNA expression. Chemistry & Biology. 9: 821-7. PMID 12144926 DOI: 10.1016/S1074-5521(02)00174-6  0.787
2002 Wang L, Schultz PG. Expanding the genetic code. Chemical Communications (Cambridge, England). 1-11. PMID 12120285 DOI: 10.1039/B108185N  0.402
2002 Gildersleeve J, Janes J, Ulrich H, Yang P, Barbas C, Schultz PG. Development of a genetic selection for catalytic antibodies. Bioorganic & Medicinal Chemistry Letters. 12: 1691-4. PMID 12039592 DOI: 10.1016/S0960-894X(02)00198-1  0.793
2002 Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, Hogenesch JB. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 109: 307-20. PMID 12015981 DOI: 10.1016/S0092-8674(02)00722-5  0.773
2002 Xia G, Chen L, Sera T, Fa M, Schultz PG, Romesberg FE. Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America. 99: 6597-602. PMID 12011423 DOI: 10.1073/Pnas.102577799  0.785
2002 Perez OD, Chang YT, Rosania G, Sutherlin D, Schultz PG. Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors. Chemistry & Biology. 9: 475-83. PMID 11983336 DOI: 10.1016/S1074-5521(02)00131-X  0.787
2002 Santoro SW, Schultz PG. Directed evolution of the site specificity of Cre recombinase. Proceedings of the National Academy of Sciences of the United States of America. 99: 4185-90. PMID 11904359 DOI: 10.1073/Pnas.022039799  0.801
2002 Su AI, Cooke MP, Ching KA, Hakak Y, Walker JR, Wiltshire T, Orth AP, Vega RG, Sapinoso LM, Moqrich A, Patapoutian A, Hampton GM, Schultz PG, Hogenesch JB. Large-scale analysis of the human and mouse transcriptomes. Proceedings of the National Academy of Sciences of the United States of America. 99: 4465-70. PMID 11904358 DOI: 10.1073/Pnas.012025199  0.779
2002 Ding S, Gray NS, Ding Q, Wu X, Schultz PG. Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purines. Journal of Combinatorial Chemistry. 4: 183-6. PMID 11886295 DOI: 10.1021/Cc010080I  0.691
2002 Watanabe CM, Supekova L, Schultz PG. Transcriptional effects of the potent enediyne anti-cancer agent Calicheamicin gamma(I)(1). Chemistry & Biology. 9: 245-51. PMID 11880039 DOI: 10.1016/S1074-5521(02)00103-5  0.794
2002 Anderson JC, Magliery TJ, Schultz PG. Exploring the limits of codon and anticodon size. Chemistry & Biology. 9: 237-44. PMID 11880038 DOI: 10.1016/S1074-5521(02)00094-7  0.786
2002 Chang YT, Choi J, Ding S, Prieschl EE, Baumruker T, Lee JM, Chung SK, Schultz PG. The synthesis and biological characterization of a ceramide library. Journal of the American Chemical Society. 124: 1856-7. PMID 11866590 DOI: 10.1021/Ja017576O  0.779
2002 Wang L, Brock A, Schultz PG. Adding L-3-(2-Naphthyl)alanine to the genetic code of E. coli. Journal of the American Chemical Society. 124: 1836-7. PMID 11866580 DOI: 10.1021/Ja012307J  0.39
2002 Ding S, Gray NS, Wu X, Ding Q, Schultz PG. A combinatorial scaffold approach toward kinase-directed heterocycle libraries. Journal of the American Chemical Society. 124: 1594-6. PMID 11853431 DOI: 10.1021/Ja0170302  0.723
2002 Block-Alper L, Webster P, Zhou X, Supeková L, Wong WH, Schultz PG, Meyer DI. IN02, a positive regulator of lipid biosynthesis, is essential for the formation of inducible membranes in yeast. Molecular Biology of the Cell. 13: 40-51. PMID 11809821 DOI: 10.1091/Mbc.01-07-0366  0.73
2002 Santarsiero BD, Yegian DT, Lee CC, Spraggon G, Gu J, Scheibe D, Uber DC, Cornell EW, Nordmeyer RA, Kolbe WF, Jin J, Jones AL, Jaklevic JM, Schultz PG, Stevens RC. An approach to rapid protein crystallization using nanodroplets Journal of Applied Crystallography. 35: 278-281. DOI: 10.1107/S0021889802001474  0.631
2002 Gildersleeve J, Janes J, Ulrich H, Yang P, Barbas C, Schultz PG. Corrigendum to “Development of a Genetic Selection for Catalytic Antibodies” [Bioorg. Med. Chem. Lett. 12 (2002) 1691]† Bioorganic & Medicinal Chemistry Letters. 12: 2789. DOI: 10.1016/S0960-894X(02)00562-0  0.773
2002 Schultz PG, Yin J, Lerner RA. Die Chemie von Antikörpern Angewandte Chemie. 114: 4607-4618. DOI: 10.1002/1521-3757(20021202)114:23<4607::Aid-Ange4607>3.0.Co;2-U  0.545
2001 Winssinger N, Harris JL, Backes BJ, Schultz PG. From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling. Angewandte Chemie (International Ed. in English). 40: 3152-3155. PMID 29712061 DOI: 10.1002/1521-3773(20010903)40:17<3152::Aid-Anie3152>3.0.Co;2-P  0.673
2001 Ting AY, Witte K, Shah K, Kraybill B, Shokat KM, Schultz PG. Phage-display evolution of tyrosine kinases with altered nucleotide specificity. Biopolymers. 60: 220-8. PMID 11774228 DOI: 10.1002/1097-0282(2001)60:3<220::Aid-Bip10035>3.0.Co;2-C  0.779
2001 Chang YT, Wignall SM, Rosania GR, Gray NS, Hanson SR, Su AI, Merlie J, Moon HS, Sangankar SB, Perez O, Heald R, Schultz PG. Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors. Journal of Medicinal Chemistry. 44: 4497-500. PMID 11741468 DOI: 10.1021/Jm010451+  0.783
2001 Atwell S, Meggers E, Spraggon G, Schultz PG. Structure of a copper-mediated base pair in DNA. Journal of the American Chemical Society. 123: 12364-7. PMID 11734038 DOI: 10.1021/Ja011822E  0.749
2001 Ding S, Gray NS, Ding Q, Schultz PG. A concise and traceless linker strategy toward combinatorial libraries of 2,6,9-substituted purines. The Journal of Organic Chemistry. 66: 8273-6. PMID 11722241 DOI: 10.1021/Jo016010F  0.668
2001 Wu TY, Ding S, Gray NS, Schultz PG. Solid-phase synthesis of 2,3,5-trisubstituted indoles. Organic Letters. 3: 3827-30. PMID 11720546 DOI: 10.1021/Ol016525T  0.714
2001 Lin Q, Jiang F, Schultz PG, Gray NS. Design of allele-specific protein methyltransferase inhibitors Journal of the American Chemical Society. 123: 11608-11613. PMID 11716715 DOI: 10.1021/Ja011423J  0.776
2001 Su AI, Welsh JB, Sapinoso LM, Kern SG, Dimitrov P, Lapp H, Schultz PG, Powell SM, Moskaluk CA, Frierson HF, Hampton GM. Molecular classification of human carcinomas by use of gene expression signatures. Cancer Research. 61: 7388-93. PMID 11606367  0.63
2001 Wang L, Schultz PG. A general approach for the generation of orthogonal tRNAs. Chemistry & Biology. 8: 883-90. PMID 11564556 DOI: 10.1016/S1074-5521(01)00063-1  0.404
2001 Pastrnak M, Schultz PG. Phage selection for site-specific incorporation of unnatural amino acids into proteins in vivo. Bioorganic & Medicinal Chemistry. 9: 2373-9. PMID 11553478 DOI: 10.1016/S0968-0896(01)00157-2  0.778
2001 Spence MM, Rubin SM, Dimitrov IE, Ruiz EJ, Wemmer DE, Pines A, Yao SQ, Tian F, Schultz PG. Functionalized xenon as a biosensor. Proceedings of the National Academy of Sciences of the United States of America. 98: 10654-7. PMID 11535830 DOI: 10.1073/Pnas.191368398  0.772
2001 Yin J, Mundorff EC, Yang PL, Wendt KU, Hanway D, Stevens RC, Schultz PG. A comparative analysis of the immunological evolution of antibody 28B4. Biochemistry. 40: 10764-73. PMID 11535051 DOI: 10.1021/Bi010536C  0.792
2001 Hogenesch JB, Ching KA, Batalov S, Su AI, Walker JR, Zhou Y, Kay SA, Schultz PG, Cooke MP. A comparison of the Celera and Ensembl predicted gene sets reveals little overlap in novel genes. Cell. 106: 413-5. PMID 11534548 DOI: 10.1016/S0092-8674(01)00467-6  0.763
2001 Verdugo DE, Cancilla MT, Ge X, Gray NS, Chang YT, Schultz PG, Negishi M, Leary JA, Bertozzi CR. Discovery of estrogen sulfotransferase inhibitors from a purine library screen. Journal of Medicinal Chemistry. 44: 2683-6. PMID 11495578 DOI: 10.1021/Jm010171U  0.626
2001 Tae EL, Wu Y, Xia G, Schultz PG, Romesberg FE. Efforts toward expansion of the genetic alphabet: replication of DNA with three base pairs. Journal of the American Chemical Society. 123: 7439-40. PMID 11472182 DOI: 10.1021/Ja010731E  0.767
2001 Grunwell JR, Glass JL, Lacoste TD, Deniz AA, Chemla DS, Schultz PG. Monitoring the conformational fluctuations of DNA hairpins using single-pair fluorescence resonance energy transfer. Journal of the American Chemical Society. 123: 4295-303. PMID 11457196 DOI: 10.1021/Ja0027620  0.602
2001 Harmse L, van Zyl R, Gray N, Schultz P, Leclerc S, Meijer L, Doerig C, Havlik I. Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum. Biochemical Pharmacology. 62: 341-8. PMID 11434907 DOI: 10.1016/S0006-2952(01)00644-X  0.462
2001 Watanabe CM, Wolffram S, Ader P, Rimbach G, Packer L, Maguire JJ, Schultz PG, Gohil K. The in vivo neuromodulatory effects of the herbal medicine ginkgo biloba. Proceedings of the National Academy of Sciences of the United States of America. 98: 6577-80. PMID 11381109 DOI: 10.1073/Pnas.111126298  0.679
2001 Deniz AA, Laurence TA, Dahan M, Chemla DS, Schultz PG, Weiss S. Ratiometric single-molecule studies of freely diffusing biomolecules. Annual Review of Physical Chemistry. 52: 233-53. PMID 11326065 DOI: 10.1146/Annurev.Physchem.52.1.233  0.604
2001 Wang L, Brock A, Herberich B, Schultz PG. Expanding the genetic code of Escherichia coli. Science (New York, N.Y.). 292: 498-500. PMID 11313494 DOI: 10.1126/Science.1060077  0.806
2001 Magliery TJ, Anderson JC, Schultz PG. Expanding the genetic code: selection of efficient suppressors of four-base codons and identification of "shifty" four-base codons with a library approach in Escherichia coli. Journal of Molecular Biology. 307: 755-69. PMID 11273699 DOI: 10.1006/Jmbi.2001.4518  0.805
2001 Lu T, Ting AY, Mainland J, Jan LY, Schultz PG, Yang J. Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter. Nature Neuroscience. 4: 239-46. PMID 11224539 DOI: 10.1038/85080  0.595
2001 Ding S, Gray NS, Ding Q, Schultz PG. Expanding the diversity of purine libraries Tetrahedron Letters. 42: 8751-8755. DOI: 10.1016/S0040-4039(01)01925-6  0.672
2001 Winssinger N, Harris JL, Backes BJ, Schultz PG. From split-pool libraries to spatially addressable microarrays and its application to functional proteomic profiling Angewandte Chemie - International Edition. 40: 3152-3155. DOI: 10.1002/1521-3773(20010903)40:17<3152::AID-ANIE3152>3.0.CO;2-P  0.598
2001 Winssinger N, Harris JL, Backes BJ, Schultz PG. Cover Picture Angewandte Chemie International Edition. 40: 3083-3083. DOI: 10.1002/1521-3773(20010903)40:17<3083::AID-ANIE3083>3.0.CO;2-J  0.573
2001 Winssinger N, Harris JL, Backes BJ, Schultz PG. Von Split-Pool-Molekülbibliotheken zu räumlich adressierbaren Mikro-Arrays und deren Einsatz in der funktionellen Proteomik Angewandte Chemie. 113: 3254-3258. DOI: 10.1002/1521-3757(20010903)113:17<3254::Aid-Ange3254>3.0.Co;2-9  0.614
2000 Simeonov A, Matsushita M, Juban EA, Thompson EH, Hoffman TZ, Beuscher AE, Taylor MJ, Wirsching P, Rettig W, McCusker JK, Stevens RC, Millar DP, Schultz PG, Lerner RA, Janda KD. Blue-fluorescent antibodies. Science (New York, N.Y.). 290: 307-13. PMID 11030644 DOI: 10.1126/Science.290.5490.307  0.604
2000 Berger M, Ogawa AK, McMinn DL, Wu Y, Schultz PG, Romesberg FE. Stable and Selective Hybridization of Oligonucleotides with Unnatural Hydrophobic Bases This work was supported by the National Institutes of Health (GM 60005 to F.E.R.) and the Skaggs Institute for Chemical Biology (F.E.R. and P.G.S.). A.K.O. thanks the National Institutes of Health for a postdoctoral fellowship (F32 GM19833-01). Angewandte Chemie (International Ed. in English). 39: 2940-2942. PMID 11028017 DOI: 10.1002/1521-3773(20000818)39:16<2940::Aid-Anie2940>3.0.Co;2-#  0.76
2000 Simbulan-Rosenthal CM, Ly DH, Rosenthal DS, Konopka G, Luo R, Wang ZQ, Schultz PG, Smulson ME. Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase. Proceedings of the National Academy of Sciences of the United States of America. 97: 11274-9. PMID 11016956 DOI: 10.1073/Pnas.200285797  0.634
2000 Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J, Shimizu E, Tsien JZ, Schultz PG, Rose MD, Wood JL, Morgan DO, Shokat KM. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 407: 395-401. PMID 11014197 DOI: 10.1038/35030148  0.79
2000 Berger M, Wu Y, Ogawa AK, McMinn DL, Schultz PG, Romesberg FE. Universal bases for hybridization, replication and chain termination. Nucleic Acids Research. 28: 2911-4. PMID 10908353 DOI: 10.1093/Nar/28.15.2911  0.775
2000 Knockaert M, Gray N, Damiens E, Chang YT, Grellier P, Grant K, Fergusson D, Mottram J, Soete M, Dubremetz JF, Le Roch K, Doerig C, Schultz P, Meijer L. Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. Chemistry & Biology. 7: 411-22. PMID 10873834 DOI: 10.1016/S1074-5521(00)00124-1  0.475
2000 Guo Z, Zhou D, Schultz PG. Designing small-molecule switches for protein-protein interactions. Science (New York, N.Y.). 288: 2042-5. PMID 10856217 DOI: 10.1126/Science.288.5473.2042  0.586
2000 Deniz AA, Laurence TA, Beligere GS, Dahan M, Martin AB, Chemla DS, Dawson PE, Schultz PG, Weiss S. Single-molecule protein folding: diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2. Proceedings of the National Academy of Sciences of the United States of America. 97: 5179-84. PMID 10792044 DOI: 10.1073/Pnas.090104997  0.685
2000 Armstrong JI, Portley AR, Chang YT, Nierengarten DM, Cook BN, Bowman KG, Bishop A, Gray NS, Shokat KM, Schultz PG, Bertozzi CR. Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library We thank Sharon Long and Dave Keating for providing both the NodH sulfotransferase and APS Kinase during our preliminary experiments and Jack Kirsch for numerous helpful conversations. J.I.A. and K.G.B were supported by NIH Molecular Biophysics Training Grant (No. T32GM0895). This research was funded by grants to C.R.B. from the Pew Scholars Program, the W. M. Keck Foundation and the American Cancer Society (Grant No. RPG9700501BE). Angewandte Chemie (International Ed. in English). 39: 1303-1306. PMID 10767039 DOI: 10.1002/(Sici)1521-3773(20000403)39:7<1303::Aid-Anie1303>3.0.Co;2-0  0.772
2000 Ly DH, Lockhart DJ, Lerner RA, Schultz PG. Mitotic misregulation and human aging. Science (New York, N.Y.). 287: 2486-92. PMID 10741968 DOI: 10.1126/Science.287.5462.2486  0.67
2000 Rosania GR, Chang YT, Perez O, Sutherlin D, Dong H, Lockhart DJ, Schultz PG. Myoseverin, a microtubule-binding molecule with novel cellular effects. Nature Biotechnology. 18: 304-8. PMID 10700146 DOI: 10.1038/73753  0.795
2000 Mundorff EC, Hanson MA, Varvak A, Ulrich H, Schultz PG, Stevens RC. Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement. Biochemistry. 39: 627-32. PMID 10651626 DOI: 10.1021/Bi9924314  0.746
2000 Meggers E, Holland PL, Tolman WB, Romesberg FE, Schultz PG. A novel copper-mediated DNA base pair [6] Journal of the American Chemical Society. 122: 10714-10715. DOI: 10.1021/Ja0025806  0.727
2000 Wang L, Magliery TJ, Liu DR, Schultz PG. A new functional suppressor tRNA/aminoacyl-tRNA synthetase pair for the in vivo incorporation of unnatural amino acids into proteins [16] Journal of the American Chemical Society. 122: 5010-5011. DOI: 10.1021/Ja000595Y  0.803
2000 Pastrnak M, Magliery TJ, Schultz PG. A new orthogonal suppressor tRNA/aminoacyl-tRNA synthetase pair for evolving an organism with an expanded genetic code Helvetica Chimica Acta. 83: 2277-2286. DOI: 10.1002/1522-2675(20000906)83:9<2277::Aid-Hlca2277>3.0.Co;2-L  0.806
2000 Berger M, Ogawa AK, McMinn D, Wu Y, Schultz PG, Romesberg FE. Stabile und selektive Hybridisierung von Oligonucleotiden unter Verwendung nichtnatürlicher hydrophober Basen Angewandte Chemie. 112: 3069-3071. DOI: 10.1002/1521-3757(20000818)112:16<3069::Aid-Ange3069>3.0.Co;2-K  0.757
1999 Loweth CJ, Caldwell WB, Peng X, Alivisatos AP, Schultz PG. DNA-Based Assembly of Gold Nanocrystals. Angewandte Chemie (International Ed. in English). 38: 1808-1812. PMID 29711189 DOI: 10.1002/(Sici)1521-3773(19990614)38:12<1808::Aid-Anie1808>3.0.Co;2-C  0.769
1999 Martin AB, Schultz PG. Opportunities at the interface of chemistry and biology. Trends in Cell Biology. 9: M24-8. PMID 10611676 DOI: 10.1016/S0962-8924(99)01682-7  0.454
1999 Yang PL, Schultz PG. Mutational analysis of the affinity maturation of antibody 48G7. Journal of Molecular Biology. 294: 1191-201. PMID 10600377 DOI: 10.1006/Jmbi.1999.3197  0.786
1999 Chang YT, Schultz PG. Versatile fluorescence labeling method using activated esters on solid support. Bioorganic & Medicinal Chemistry Letters. 9: 2479-82. PMID 10498192 DOI: 10.1016/S0960-894X(99)00422-9  0.468
1999 Cho CY, Liu CW, Wemmer DE, Schultz PG. Cyclic and linear oligocarbamate ligands for human thrombin. Bioorganic & Medicinal Chemistry. 7: 1171-9. PMID 10428389 DOI: 10.1016/S0968-0896(99)00028-0  0.68
1999 Romesberg FE, Schultz PG. A mutational study of a Diels-Alderase catalytic antibody. Bioorganic & Medicinal Chemistry Letters. 9: 1741-4. PMID 10406634 DOI: 10.1016/S0960-894X(99)00281-4  0.666
1999 Chang YT, Gray NS, Rosania GR, Sutherlin DP, Kwon S, Norman TC, Sarohia R, Leost M, Meijer L, Schultz PG. Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chemistry & Biology. 6: 361-75. PMID 10375538 DOI: 10.1016/S1074-5521(99)80048-9  0.802
1999 Yao S, Anex DS, Caldwell WB, Arnold DW, Smith KB, Schultz PG. SDS capillary gel electrophoresis of proteins in microfabricated channels. Proceedings of the National Academy of Sciences of the United States of America. 96: 5372-7. PMID 10318890 DOI: 10.1073/Pnas.96.10.5372  0.789
1999 Rosania GR, Merlie J, Gray N, Chang YT, Schultz PG, Heald R. A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proceedings of the National Academy of Sciences of the United States of America. 96: 4797-802. PMID 10220373 DOI: 10.1073/Pnas.96.9.4797  0.687
1999 Liu DR, Schultz PG. Progress toward the evolution of an organism with an expanded genetic code. Proceedings of the National Academy of Sciences of the United States of America. 96: 4780-5. PMID 10220370 DOI: 10.1073/Pnas.96.9.4780  0.494
1999 Deniz AA, Dahan M, Grunwell JR, Ha T, Faulhaber AE, Chemla DS, Weiss S, Schultz PG. Single-pair fluorescence resonance energy transfer on freely diffusing molecules: observation of Förster distance dependence and subpopulations. Proceedings of the National Academy of Sciences of the United States of America. 96: 3670-5. PMID 10097095 DOI: 10.1073/Pnas.96.7.3670  0.607
1999 Kanamori T, Nishikawa S, Nakai M, Shin I, Schultz PG, Endo T. Uncoupling of transfer of the presequence and unfolding of the mature domain in precursor translocation across the mitochondrial outer membrane. Proceedings of the National Academy of Sciences of the United States of America. 96: 3634-9. PMID 10097089 DOI: 10.1073/Pnas.96.7.3634  0.485
1999 Ha T, Ting AY, Liang J, Caldwell WB, Deniz AA, Chemla DS, Schultz PG, Weiss S. Single-molecule fluorescence spectroscopy of enzyme conformational dynamics and cleavage mechanism. Proceedings of the National Academy of Sciences of the United States of America. 96: 893-8. PMID 9927664 DOI: 10.1073/Pnas.96.3.893  0.777
1999 Gohil K, Packer L, Gray N, Rosania GR, Moy RK, Maguire J, Schultz PG. mRNA expression profile of a human cancer cell line in response to a phytochemical extract with antioxidant properties Nature Genetics. 23: 47-47. DOI: 10.1038/14313  0.432
1999 Ma L, Sweet EH, Schultz PG. Selective antibody-catalyzed solvolysis of endo-2-norbornyl mesylate [9] Journal of the American Chemical Society. 121: 10227-10228. DOI: 10.1021/Ja990896B  0.721
1999 Dahan M, Deniz AA, Ha T, Chemla DS, Schultz PG, Weiss S. Ratiometric measurement and identification of single diffusing molecules Chemical Physics. 247: 85-106. DOI: 10.1016/S0301-0104(99)00132-9  0.594
1999 Loweth CJ, Caldwell WB, Peng X, Alivisatos AP, Schultz PG. DNA als Gerüst zur Bildung von Aggregaten aus Gold-Nanokristallen Angewandte Chemie. 111: 1925-1929. DOI: 10.1002/(Sici)1521-3757(19990614)111:12<1925::Aid-Ange1925>3.0.Co;2-2  0.757
1999 Liu DR, Schultz PG. Das Hervorbringen neuer molekularer Funktionen: ein Lehrstück der Natur Angewandte Chemie. 111: 36-56. DOI: 10.1002/(Sici)1521-3757(19990115)111:1/2<36::Aid-Ange36>3.0.Co;2-J  0.372
1998 Pollitt SK, Schultz PG. A Photochemical Switch for Controlling Protein-Protein Interactions. Angewandte Chemie (International Ed. in English). 37: 2104-2107. PMID 29711048 DOI: 10.1002/(Sici)1521-3773(19980817)37:15<2104::Aid-Anie2104>3.0.Co;2-Z  0.792
1998 Schultz PG. Bringing biological solutions to chemical problems Proceedings of the National Academy of Sciences of the United States of America. 95: 14590-14591. PMID 9843932 DOI: 10.1073/Pnas.95.25.14590  0.322
1998 Romesberg FE, Santarsiero BD, Spiller B, Yin J, Barnes D, Schultz PG, Stevens RC. Structural and kinetic evidence for strain in biological catalysis. Biochemistry. 37: 14404-9. PMID 9772166 DOI: 10.1021/Bi981578C  0.757
1998 Thorson JS, Cornish VW, Barrett JE, Cload ST, Yano T, Schultz PG. A biosynthetic approach for the incorporation of unnatural amino acids into proteins. Methods in Molecular Biology (Clifton, N.J.). 77: 43-73. PMID 9770661 DOI: 10.1385/0-89603-397-X:43  0.796
1998 Pedersen H, Hölder S, Sutherlin DP, Schwitter U, King DS, Schultz PG. A method for directed evolution and functional cloning of enzymes. Proceedings of the National Academy of Sciences of the United States of America. 95: 10523-8. PMID 9724736 DOI: 10.1073/Pnas.95.18.10523  0.797
1998 Gray NS, Wodicka L, Thunnissen AM, Norman TC, Kwon S, Espinoza FH, Morgan DO, Barnes G, LeClerc S, Meijer L, Kim SH, Lockhart DJ, Schultz PG. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science (New York, N.Y.). 281: 533-8. PMID 9677190 DOI: 10.1126/Science.281.5376.533  0.721
1998 Ma L, Hsieh-Wilson LC, Schultz PG. Antibody catalysis of peptidyl-prolyl cis-trans isomerization in the folding of RNase T1. Proceedings of the National Academy of Sciences of the United States of America. 95: 7251-6. PMID 9636134 DOI: 10.1073/Pnas.95.13.7251  0.791
1998 Romesberg FE, Spiller B, Schultz PG, Stevens RC. Immunological origins of binding and catalysis in a Diels-Alderase antibody. Science (New York, N.Y.). 279: 1929-33. PMID 9506942 DOI: 10.1126/Science.279.5358.1929  0.732
1998 Yu J, Choi SY, Moon KD, Chung HH, Youn HJ, Jeong S, Park H, Schultz PG. A glycosidase antibody elicited against a chair-like transition state analog by in vitro immunization. Proceedings of the National Academy of Sciences of the United States of America. 95: 2880-4. PMID 9501184 DOI: 10.1073/Pnas.95.6.2880  0.538
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